Compatibility of Commonly Used Intravenous Drugs

PRINTER-FRIENDLY VERSION AT

Compatibility of

ll

A

s

ite

d.

ib

te

oh

no

pr

e

is

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rw

on

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is

ot

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up

ith

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ng

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in

is

bl

or

Pu

le

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ah in w

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n

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tio

11

uc

20

od

?

pr

ht

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rig ed.

py

rv

se

re

ht

Co

rig

Commonly Used

Intravenous

Drugs

LISA CAYO, PHARMD

Clinical Pharmacy Coordinator

Garden City Hospital

Garden City, Michigan

T

he number of available IV

medications continues to expand.

Many institutions have observed an

increase in patient acuity and a rise in the

number of medications administered to

each patient. This increases the likelihood

that multiple IV medications will need

to be administered concurrently.

medication is combined or added to an IV fluid. It is

important to recognize that compatibility is not just

a function of the drugs themselves, but also can be

dependent on a variety of factors including the concentration, temperature, storage vehicle, infusion solution,

order of mixing, and administration technique. Compatibility differences even have been reported for different

brands of the same drug.

Three types of incompatibilities are commonly discussed: physical, chemical, and therapeutic. Physical

d.

These factors contribute to the escalating complexity of IV drug administration and have resulted in an

ever-increasing number of possible incompatibilities.

The potential for serious and life-threatening adverse

drug events exists when incompatible medications are

infused together. Therefore, it is important to verify drug

compatibility prior to coadministration. A clear and concise compatibility chart can be a useful tool in helping to

deliver safe, high-quality IV therapy to patients.

A chance of incompatibility exists whenever any

Text continues on page 6

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

P H A R M AC Y P R AC T I C E N E WS ? S E P T E M B E R 2 0 1 1

1

I

C

C

C

N

C

I

C

C

C

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C

C

I

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N

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I

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I

C

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N

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I

C

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N

N

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N

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C

ll

rig

N

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I

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A

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C

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N

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N

C

C

I

C

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C

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N

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N

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N

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N

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I

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N

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N

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I

A

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N

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I

I

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I

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I

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N

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I

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N

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N

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N

I

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N

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N

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N

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I

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N

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I

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N

N

C

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I

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N

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N

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N

N

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I

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N

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N

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N

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I

N

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I

I

N

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N

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on

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se

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ht

N

C

N

I

N

Anidulafungin

C

C

C

C

C

C

N

I

N

N

C

N

I

N

N

N

C

N

I

C

N

N

N

C

N

I

C

C

I

C

C

C

C

C

C

C

C

C

N

N

C

N

N

C

C

C

C

C

N

N

C

N

N

C

C

C

N

C

C

I

I

C

N

N

C

I

C

C

C

C

N

N

N

C

N

N

C

C

C

C

I

I

H

N

N

C

C

N

N

C

C

C

C

I

N

C

C

N

N

I

C

N

I

C

C

C

C

I

I

N

C

C

N

N

I

C

N

N

C

C

C

C

I

C

N

C

C

C

C

N

N

N

N

C

N

N

C

C

I

N

N

N

N

C

C

I

N

N

C

N

I

C

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C

C

I

C

N

I

C

N

C

C

C

I

N

C

N

N

C

C

C

C

C

C

N

I

I

N

C

C

C

C

N

N

C

N

I

C

C

C

I

I

C

N

C

C

N

C

C

I

C

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N

I

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N

I

C

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N

A

C

N

I

N

N

C

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N

N

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C

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S

N

C

N

I

C

C

C

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I

C

C

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C

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I

I

I

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

N

N

N

C

N

N

C

C

C

I

I

C

C

C

C

C

C

C

C

I

C

C

C

C

N

I

A

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

I

C

I

I

N

I

I

I

N

N

I

I

I

I

I

I

I

I

I

I

I

I

I

N

I

C

I

N

C

C

N

N

C

C

N

C

C

C

C

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C

I

C

C

C

C

C

C

C

C

C

C

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I

N

C

N

I

N

C

C

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N

C

C

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I

I

I

I

C

I

C

I

C

C

C

I

C

I

C

I

C

C

I

I

C

C

N

C

N

N

N

C

I

N

N

I

N

N

N

I

C

N

C

I

C

N

C

C

I

C

C

I

N

C

C

N

C

C

C

C

C

I

N

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

N

N

C

N

C

N

N

C

C

C

N

N

N

N

C

N

N

N

C

N

C

C

C

I

C

C

C

C

C

C

C

I

I

C

N

N

C

C

C

C

C

I

N

C

I

N

I

I

C

N

C

C

I

C

I

C

C

C

C

N

C

C

N

N

N

C

N

N

C

C

C

C

I

C

I

C

C

C

C

C

C

N

C

C

C

C

I

C

C

C

C

C

C

I

C

C

N

N

C

N

N

C

C

C

C

C

C

N

C

C

N

C

C

C

N

C

C

C

C

I

C

C

C

C

N

C

C

I

C

N

C

C

C

C

C

C

C

C

C

N

C

C

C

C

N

C

C

C

C

C

C

C

C

I

C

C

C

N

N

C

C

C

I

C

C

N

N

C

N

N

C

C

C

C

C

C

N

C

C

N

C

C

C

N

C

C

I

C

I

C

C

C

C

C

C

C

C

C

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

C

N

N

N

N

N

N

N

C

N

N

N

N

N

C

N

N

N

N

N

C

C

C

N

N

C

N

I

C

C

C

C

C

N

I

C

N

C

C

N

N

N

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

N

N

C

C

I

C

C

C

C

C

C

N

C

C

C

C

C

C

N

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

N

s

Bumetanide

Calcium gluconate

Caspofungin

Cefazolin

Cefepime

Cefotaxime

Cefoxitin

Ceftaroline

Ceftazidime

Ceftizoxime

Ceftriaxone

Ciprofloxacin

Clindamycin

Daptomycin

Dexamethasone

D5W

Diazepam

Diltiazem

Diphenhydramine

Dobutamine

Dopamine

Doripenem

Doxycycline

Enalaprilat

Epinephrine

Eptifibatide

Esmolol

Esomeprazole

Famotidine

Fentanyl

N

N

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

C

C

C

C

C

C

C

N

C

C

C

I

C

C

C

C

C

N

C

N

C

C

C

N

C

N

C

N

N

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

C

C

C

N

C

C

C

C

C

C

C

N

C

C

C

C

C

C

N

C

C

C

I

C

N

C

C

C

I

C

N

N

N

N

N

C

C

N

C

C

C

C

Protect from light. b Testing was performed with ethylenediaminetetra-acetic acid (EDTA)-free formulation.

d.

KEY

A = Physically compatible for at least 2 hours

H = Physically compatible for at least 1 hour

C = Physically compatible

I = Incompatible

D = Physically compatible in dextrose 5% in water

N = Information on compatibility is not available or not adequate

E = Physically compatible for at least 5 minutes

R = Physically compatible for 24 hours under refrigeration

G = Physically compatible in glass bottle only

S = Physically compatible in 0.9% sodium chloride

2

Gentamicin

N

I

I

Bivalirudin

Furosemide

C

N

Ampicillin-sulbactam

Aztreonam

Fluconazole

C

C

N

Azithromycin

Fentanyl

I

N

N

Argatroban

Famotidine

Esomeprazole

Esmolol

Eptifibatide

Epinephrine

Enalaprilat

Doxycycline

Doripenem

Dopamine

Dobutamine

Diphenhydramine

Diltiazem

Diazepam

Dextrose 5% in water

Dexamethasone

Daptomycin

Clindamycin

Ciprofloxacin

Ceftriaxone

Ceftizoxime

Ceftazidime

Ceftaroline

Cefoxitin

Cefotaxime

Cefepime

Cefazolin

Caspofungin

Calcium gluconate

Bumetanide

Bivalirudin

Aztreonam

Azithromycin

Argatroban

Anidulafungin

Ampicillin-sulbactam

Ampicillin

C

N

C

Ampicillin

a

Amiodarone

N

C

C

Amiodarone

(continued)

Co

A

C

Acyclovir

Amikacin

Amikacin

Acyclovir

Table. Compatibility of Selected IV Drugs

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

C

Labetalol

Levofloxacin

Linezolid

Lorazepam

Magnesium sulfate

Mannitol

Meropenem

Methylprednisolone sod. Succ.

Metoclopramide

Metronidazole

Micafungin

Midazolam

Morphine sulfate

Nafcillin

Nitroglycerin

Nitroprussidea

Norepinephrine

Ondansetron

Palonosetron

Pantoprazoleb

Penicillin G Potassium

Phenylephrine

Phenytoin

Piperacillin-tazobactam

Potassium chloride

Prochlorperazine

Propofol

Ringer¡¯s, lactated

Sodium bicarbonate

Sodium chloride 0.9%

Tacrolimus

Tigecycline

Tobramycin

TMP-SMX

Vancomycin

Vasopressin

Voriconazole

C

N

C

N

C

N

I

N

C

C

I

N

I

I

N

C

I

I

I

C

I

C

N

C

C

I

C

C

C

C

C

C

Acyclovir

C

C

N

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

I

C

C

C

C

C

C

I

C

C

C

Amikacin

C

I

C

C

N

C

N

C

I

C

C

N

C

N

C

N

C

N

C

C

N

I

C

N

N

N

I

N

C

I

C

N

C

C

C

Amiodarone

C

C

C

C

C

I

N

N

I

C

C

S

N

N

N

N

N

C

N

N

C

N

N

N

C

C

C

C

C

C

C

C

C

C

N

N

C

C

N

N

N

N

N

N

N

N

N

I

N

N

N

N

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

N

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

N

I

C

C

C

C

C

C

H

N

C

C

C

C

C

C

C

C

I

N

C

C

C

C

C

C

I

I

I

C

C

C

C

C

N

C

I

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

I

C

N

C

I

I

C

N

N

N

N

C

C

C

C

C

C

C

N

C

C

C

C

C

C

I

C

C

C

C

C

C

C

N

C

C

I

C

C

C

N

C

C

N

C

C

C

C

I

I

I

N

I

I

I

I

I

C

N

N

C

C

N

C

C

C

C

N

N

C

C

I

C

C

C

C

N

I

C

N

N

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

N

C

C

C

C

C

I

I

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

N

C

C

C

C

N

N

C

C

C

C

C

C

N

N

N

N

N

N

N

N

N

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

Insulin, regular

C

I

Imipenem-cilastatin

Hydromorphone

C

C

Hydrocortisone Sod. Succ.

C

C

Heparin

C

C

Granisetron

I

C

C

C

A

C

C

ll

rig

N

C

I

N

N

N

N

N

N

C

N

I

N

I

N

I

N

I

C

C

I

N

I

N

N

I

C

I

I

C

N

C

N

I

N

N

C

Ampicillin

I

N

N

N

I

N

C

N

I

N

N

N

N

N

I

C

C

N

N

I

N

N

I

N

R

N

C

N

C

N

I

N

N

C

Ampicillin-sulbactam

C

I

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

N

C

I

C

C

C

N

N

I

C

C

N

C

C

C

C

C

Anidulafungin

C

N

N

N

N

N

N

N

C

C

N

C

C

C

C

N

N

N

C

N

N

N

N

N

C

N

C

N

C

N

N

N

C

N

Argatroban

N

N

N

N

N

N

N

N

N

I

N

N

N

N

C

C

C

N

N

N

I

I

N

N

C

N

C

N

C

I

N

N

C

C

Azithromycin

I

C

C

N

C

C

I

N

C

C

N

C

C

C

C

C

I

C

C

I

C

C

I

C

C

C

C

C

C

C

N

N

C

C

Aztreonam

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

N

N

C

I

C

C

I

N

N

C

C

C

C

C

C

I

C

C

Bivalirudin

C

C

C

N

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

I

C

C

N

C

C

C

C

C

C

C

I

C

C

C

Bumetanide

C

N

C

N

I

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

C

N

C

C

I

C

C

C

C

I

C

C

C

Calcium gluconate

N

C

C

C

I

C

N

N

C

C

I

C

I

C

C

C

N

N

C

I

I

C

C

N

N

I

C

C

C

C

I

C

C

C

Caspofungin

C

N

C

N

C

C

C

N

C

C

C

C

C

C

C

C

N

C

C

I

N

C

I

C

C

C

C

C

C

N

I

N

C

C

Cefazolin

C

I

I

N

C

I

C

N

I

N

N

N

N

N

I

C

I

N

N

I

C

C

I

N

N

C

C

I

C

N

C

N

C

I

Cefepime

C

C

C

N

I

C

C

N

C

C

C

C

C

C

C

C

I

C

C

I

N

C

I

C

C

I

C

C

C

C

I

N

C

C

Cefotaxime

C

C

C

N

I

C

C

N

C

C

C

C

C

C

C

C

C

C

C

I

N

C

I

C

C

I

C

C

C

C

I

N

C

C

Cefoxitin

C

N

C

N

C

C

C

N

C

C

N

N

N

C

C

N

C

N

N

N

N

C

N

C

C

C

C

N

N

C

C

N

C

C

Ceftaroline

C

C

C

N

C

C

C

N

I

C

C

C

I

C

N

C

N

C

C

I

N

C

I

N

C

C

C

C

C

C

I

N

C

C

Ceftazidime

C

C

C

N

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

I

N

C

I

C

C

C

C

C

C

C

I

N

C

C

Ceftizoxime

C

I

C

N

C

C

C

N

C

C

C

C

C

C

N

C

C

C

C

I

N

C

I

C

I

C

C

C

C

I

I

N

C

C

Ceftriaxone

C

I

N

N

I

C

C

N

C

N

N

N

N

C

C

C

I

N

N

I

I

C

N

I

C

I

C

C

C

C

N

N

C

C

Ciprofloxacin

C

C

C

N

C

C

C

N

N

C

C

C

C

C

C

C

N

C

C

I

C

C

I

C

C

C

C

C

C

N

I

C

C

C

Clindamycin

C

C

C

C

C

C

I

N

C

C

C

I

C

C

C

C

I

N

C

I

C

C

C

N

C

C

C

C

C

C

C

I

C

C

Daptomycin

C

I

C

C

C

C

C

N

I

C

C

C

C

C

C

C

I

C

C

I

C

C

I

C

C

C

C

C

C

I

I

N

C

C

Dexamethasone

N

C

N

I

N

C

N

C

C

C

C

G

C

C

C

C

C

C

C

I

C

C

N

C

C

C

C

N

C

C

N

C

N

C

D5W

N

I

I

I

I

I

I

N

I

N

N

I

I

I

N

I

I

I

I

I

C

I

I

I

I

I

N

I

I

I

I

I

I

I

Diazepam

C

C

C

C

N

C

C

I

C

C

N

C

C

C

C

C

I

C

C

I

I

C

C

N

N

N

C

C

C

C

C

C

C

C

Diltiazem

C

C

C

C

I

C

C

N

C

C

N

C

I

C

C

C

I

C

C

I

C

C

C

C

C

I

C

C

C

C

I

C

C

C

Diphenhydramine

C

N

C

C

C

C

C

I

N

C

C

C

N

C

C

C

I

I

C

I

I

C

C

C

C

I

C

C

C

C

I

C

C

C

Dobutamine

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

C

I

C

C

C

C

C

N

C

C

C

C

I

C

C

C

Dopamine

C

C

C

N

C

C

C

C

C

C

N

N

N

C

C

N

C

N

C

N

N

C

N

I

N

C

C

C

C

C

N

C

N

C

Doripenem

C

C

C

N

I

C

C

N

C

C

I

C

C

C

C

I

C

I

C

I

I

C

C

C

N

I

C

C

N

C

I

C

C

C

Doxycycline

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

N

C

C

I

C

C

C

C

N

C

C

C

C

C

N

C

C

C

Enalaprilat

C

C

C

N

C

C

C

I

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

I

C

C

C

C

I

C

C

C

Epinephrine

C

C

C

C

C

C

C

C

C

C

N

C

N

C

C

C

N

N

C

I

C

C

C

N

N

C

C

N

C

C

C

C

N

N

Eptifibatide

C

C

C

N

N

C

C

C

C

C

N

C

C

C

C

C

I

C

C

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

Esmolol

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

C

N

C

I

N

N

N

N

N

N

Esomeprazole

C

C

C

N

C

C

C

N

C

C

C

C

C

C

C

C

I

C

C

N

I

C

C

C

C

C

C

C

C

C

I

C

C

C

Famotidine

C

C

C

N

C

C

C

N

C

C

C

C

C

C

C

C

I

C

C

I

C

C

C

C

N

C

C

C

C

C

I

C

C

C

Fentanyl

s

C

N

ite

d.

ib

te

oh

no

pr

e

is

is

rw

on

si

he

is

ot

m

er

ss

le

tp

un ou

up

ith

ro

w

G

rt

ng

pa

hi

in

is

bl

or

Pu

le

ho

on

ah in w

cM

n

M

tio

11

uc

20

od

?

pr

ht

Re

rig ed.

py

rv

se

re

ht

C

Co

I

N

Table continues on page 4

d.

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

3

Bivalirudin

Bumetanide

Calcium gluconate

Caspofungin

Cefazolin

Cefepime

Cefotaxime

Cefoxitin

Ceftaroline

Ceftazidime

Ceftizoxime

Ceftriaxone

Ciprofloxacin

Clindamycin

Daptomycin

Dexamethasone

Dextrose 5% in water

Diazepam

Diltiazem

Diphenhydramine

Dobutamine

Dopamine

Doripenem

Doxycycline

Enalaprilat

C

C

N

C

C

C

N

C

C

N

C

N

C

N

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

I

C

C

C

C

I

I

I

I

N

C

I

C

C

I

I

N

N

C

N

Gentamicin

Co

I

N

C

N

I

C

C

C

C

C

N

N

N

C

C

N

C

N

C

C

C

I

C

I

C

C

C

C

C

C

C

C

C

C

ll

rig

N

s

Heparin

Hydrocortisone

Hydromorphone

Imipenem-cilastatin

Insulin, regular

Labetalol

Levofloxacin

Linezolid

Lorazepam

Magnesium sulfate

Mannitol

Meropenem

Methylprednisolone

Metoclopramide

Metronidazole

Micafungin

Midazolam

Morphine sulfate

Nafcillin

Nitroglycerin

Nitroprussidea

Norepinephrine

Ondansetron

Palonosetron

Pantoprazoleb

Penicillin G

Phenylephrine

Phenytoin

C

C

C

N

Esmolol

N

C

C

C

N

C

C

C

C

C

N

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

I

I

S

N

C

N

N

C

C

C

C

I

C

C

C

C

C

C

C

C

I

C

C

C

N

I

N

N

N

C

C

I

C

C

C

N

N

C

C

C

C

I

C

C

N

N

N

C

C

N

C

C

C

N

C

C

C

C

C

C

C

C

C

I

C

C

C

C

I

N

N

I

C

C

I

C

C

C

N

N

C

C

C

C

N

C

C

N

N

C

C

C

N

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

N

C

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

I

N

N

C

N

I

N

C

C

N

C

C

C

C

C

N

C

C

I

N

C

I

C

N

I

C

C

N

C

N

C

C

C

C

C

N

C

C

N

C

C

C

N

C

N

N

C

N

N

C

C

C

C

C

C

H

C

I

C

C

C

C

N

C

C

C

C

I

N

I

N

N

C

C

C

N

N

C

N

N

C

C

C

N

I

C

C

N

N

C

N

N

C

C

C

C

C

N

N

I

I

I

C

C

I

N

N

C

I

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

N

C

I

C

I

C

C

C

N

N

C

C

C

C

C

I

C

N

I

C

C

C

C

N

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

C

C

C

C

C

C

N

N

C

C

C

C

C

C

C

C

C

N

C

C

N

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

I

I

C

C

N

I

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

N

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

N

N

N

I

N

N

C

C

C

N

C

N

I

C

C

N

C

C

I

I

C

C

I

C

I

C

C

N

C

C

C

C

C

C

C

N

C

C

C

N

C

C

C

N

N

N

C

N

N

C

C

C

C

C

C

I

C

C

C

C

C

C

N

C

C

C

N

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

N

N

N

N

N

C

N

N

N

C

N

N

C

N

N

N

N

N

N

N

N

N

N

C

C

I

I

C

C

C

C

N

N

C

N

C

N

N

N

N

C

C

C

C

C

C

N

I

C

N

N

C

C

C

I

I

C

C

I

I

C

C

C

C

I

C

C

C

N

I

N

I

C

C

C

I

C

C

C

N

N

C

C

C

C

C

N

C

N

N

N

C

N

N

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

N

C

C

C

C

C

C

C

N

N

I

C

C

C

N

C

C

C

C

C

C

C

C

C

C

I

C

N

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

N

N

I

N

N

N

N

N

N

N

C

C

N

N

N

N

N

N

N

N

N

N

N

N

N

C

N

I

N

I

C

C

N

N

I

C

C

N

N

N

N

C

N

I

C

C

I

I

C

C

N

C

C

N

C

C

C

I

C

C

C

I

C

C

C

N

C

I

C

I

C

C

N

C

C

C

C

C

C

C

N

C

C

C

I

C

N

C

C

N

N

C

C

I

C

C

C

C

C

C

N

C

C

C

C

C

C

N

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

N

C

C

C

N

I

N

C

N

N

N

C

C

C

I

C

N

C

C

N

C

C

C

N

C

C

C

C

N

N

N

C

C

N

I

C

C

N

N

N

C

C

C

C

N

C

C

C

N

N

C

C

N

C

C

C

C

C

C

N

C

C

N

C

C

C

N

C

I

C

G

I

C

C

C

C

N

C

C

C

C

C

N

C

C

C

N

C

I

C

N

I

N

C

C

N

C

C

C

C

I

C

N

C

C

N

I

C

C

N

C

C

C

C

I

C

I

N

C

N

C

C

C

N

C

N

C

C

C

C

C

N

C

C

N

N

C

C

N

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

N

C

I

C

N

I

I

C

C

C

C

C

C

C

C

C

I

C

C

C

N

C

N

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

I

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

I

C

C

C

C

N

I

C

C

C

C

N

C

C

C

C

C

N

C

N

C

C

C

N

C

I

N

C

C

N

N

I

I

C

C

N

C

C

I

N

I

I

C

I

I

I

I

N

C

C

N

C

N

I

N

I

I

I

N

C

C

C

C

I

N

N

N

N

C

N

C

C

N

C

N

C

C

N

C

C

C

N

C

N

C

C

I

C

C

I

C

N

I

C

C

N

C

N

C

C

C

C

C

I

C

C

N

N

C

C

N

C

C

C

C

C

C

N

C

C

N

C

C

C

N

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

I

I

N

I

I

I

N

N

I

I

I

I

I

I

I

I

I

N

I

I

I

I

I

I

I

I

I

I

I

I

I

N

I

I

I

I

N

N

N

I

N

I

I

ite

d.

ib

te

oh

no

pr

e

is

is

rw

on

si

he

is

ot

m

er

ss

le

tp

un ou

up

ith

ro

w

G

rt

ng

pa

hi

in

is

bl

or

Pu

le

ho

on

ah in w

cM

n

M

tio

11

uc

20

od

?

pr

ht

Re

rig ed.

py

rv

se

re

ht

Granisetron

N

Gentamicin

Aztreonam

C

I

Furosemide

Azithromycin

N

C

Fluconazole

Argatroban

N

C

Fentanyl

Anidulafungin

C

N

Famotidine

Ampicillin-sulbactam

N

S

Esomeprazole

Ampicillin

I

N

Eptifibatide

Amiodarone

C

C

Epinephrine

Amikacin

C

C

A

C

Furosemide

Fluconazole

N

C

I

N

N

C

N

I

C

C

C

C

I

N

C

N

N

N

N

N

N

I

C

C

C

C

C

I

C

I

C

N

I

C

C

C

C

N

I

C

C

C

N

C

C

C

N

N

C

N

I

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

I

C

N

I

I

C

N

N

I

I

N

N

C

I

I

I

I

N

I

I

I

N

I

C

I

N

I

C

C

C

C

N

C

C

C

C

C

N

C

C

C

I

C

C

I

N

C

N

N

N

N

C

N

C

C

N

C

N

C

C

C

N

C

C

I

C

N

C

C

I

N

C

C

C

I

C

C

C

N

C

N

C

C

C

C

I

N

C

N

I

R

N

C

C

C

N

C

C

N

C

N

C

C

C

C

C

I

C

C

C

C

C

I

N

C

C

C

N

N

N

C

N

C

C

C

N

C

C

C

C

C

I

I

N

I

N

N

C

C

C

I

I

C

C

I

I

C

C

C

C

I

C

C

C

C

I

N

I

I

N

C

I

C

I

C

C

N

C

C

C

C

C

Sodium chloride 0.9%

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

Tacrolimus

I

C

C

N

N

C

N

N

C

C

C

C

C

C

I

C

C

N

C

C

C

C

C

C

C

N

I

C

C

C

C

C

C

C

C

N

C

I

C

C

C

N

C

C

C

I

C

C

N

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

I

C

C

C

C

C

N

C

C

C

C

N

C

C

C

C

C

Tobramycin

C

C

C

N

N

C

N

I

C

C

C

C

C

N

N

C

C

C

C

C

I

C

N

C

I

C

I

C

C

C

C

C

C

C

C

d.

Piperacillan-tazobactam I

C

C

N

C

C

C

C

C

TMP-SMX

C

I

N

I

I

C

N

N

N

C

I

I

I

I

C

I

I

C

I

I

I

N

I

C

I

N

I

C

I

I

I

N

I

N

I

C

N

N

I

I

I

I

I

Vancomycin

C

C

C

N

N

C

N

N

N

I

C

C

C

N

N

N

N

N

N

N

N

N

C

I

N

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

I

C

Vasopressin

C

C

C

N

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

I

C

C

C

C

N

C

C

C

N

C

N

C

C

C

N

C

Voriconazole

C

C

C

C

C

C

N

C

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

C

C

N

C

N

C

C

C

C

C

Potassium chloride

Prochlorperazine

Propofol

Ringer¡¯s, lactated

Sodium bicarbonate

Tigecycline

a

(continued)

Acyclovir

Table. Compatibility of Selected IV Drugs

Protect from light. b Testing was performed with ethylenediaminetetra-acetic acid (EDTA)-free formulation.

4

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

Magnesium sulfate

Mannitol

Meropenem

Methylprednisolone sod. Succ.

Metoclopramide

Metronidazole

Micafungin

Midazolam

Morphine sulfate

Nafcillin

Nitroglycerin

Nitroprussidea

Norepinephrine

Ondansetron

Palonosetron

Pantoprazoleb

Penicillin G Potassium

Phenylephrine

Phenytoin

Piperacillin-tazobactam

Potassium chloride

Prochlorperazine

Propofol

Ringer¡¯s, lactated

Sodium bicarbonate

Sodium chloride 0.9%

Tacrolimus

Tigecycline

Tobramycin

TMP-SMX

Vancomycin

Vasopressin

Voriconazole

C

C

C

C

N

C

C

C

C

C

C

C

C

I

C

C

N

C

C

C

C

C

C

C

C

C

C

I

C

C

C

Fluconazole

C

C

C

N

C

C

I

N

C

N

C

N

I

C

N

C

I

I

C

C

I

C

C

C

C

N

C

C

I

I

N

C

Furosemide

C

C

C

C

C

C

C

C

N

C

C

N

C

C

C

C

C

C

C

C

I

N

C

C

I

C

C

C

C

C

C

I

C

C

C

Gentamicin

C

I

N

C

C

N

C

C

C

C

C

C

N

N

C

C

N

I

C

C

C

I

C

C

C

C

C

C

C

C

C

C

C

I

N

C

C

C

A

C

ll

Linezolid

rig

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

N

N

C

N

C

I

C

C

C

C

N

C

C

C

C

C

C

C

C

C

Granisetron

s

C

C

ite

d.

ib

te

oh

no

pr

e

is

is

rw

on

si

he

is

ot

m

er

ss

le

tp

un ou

up

ith

ro

w

G

rt

ng

pa

hi

in

is

bl

or

Pu

le

ho

on

ah in w

cM

n

M

tio

11

uc

20

od

?

pr

ht

Re

rig ed.

py

rv

se

re

ht

C

C

C

Levofloxacin

C

N

Labetalol

C

Insulin, regular

C

C

Imipenem-cilastatin

C

C

Co

C

C

Lorazepam

C

N

Hydromorphone

C

C

Hydrocortisone Sod. Succ.

C

C

Heparin

C

I

Granisetron

C

N

C

C

C

C

C

N

C

C

C

C

N

C

C

C

C

C

C

C

C

C

I

C

C

N

C

N

C

C

C

C

I

E

I

C

C

Heparin

C

N

C

N

N

C

C

N

N

C

N

C

C

C

C

C

N

C

C

I

C

C

N

C

C

C

C

C

C

N

I

N

C

C

Hydrocortisone

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

C

I

C

C

N

C

C

I

C

C

C

C

C

C

C

N

Hydromorphone

I

C

I

N

C

C

C

N

N

C

C

C

N

C

C

I

C

C

C

I

N

N

I

C

I

I

R

C

C

C

I

C

C

C

Imipenem-cilastatin

C

C

C

C

C

C

C

I

N

N

N

C

C

N

N

C

N

C

I

I

I

C

I

C

G

C

N

C

C

N

I

C

N

C

Insulin, regular

C

C

C

N

C

C

C

I

C

C

N

C

C

C

C

C

I

N

C

I

I

C

C

C

C

N

C

C

C

C

N

C

C

C

Labetalol

N

N

C

N

C

C

C

N

C

C

N

I

I

N

C

C

I

N

C

I

I

C

I

I

N

C

C

C

C

C

C

C

C

C

Levofloxacin

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

I

N

C

I

C

C

C

N

C

C

C

C

C

C

N

C

C

C

Linezolid

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

I

N

C

I

C

C

N

C

N

C

N

C

C

C

C

C

C

C

Lorazepam

C

C

I

C

C

C

C

C

C

C

C

C

C

C

N

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

C

Magnesium sulfate

I

C

C

C

N

C

C

C

C

C

C

C

C

N

C

C

I

C

C

C

C

N

C

N

C

C

C

I

C

C

C

Mannitol

N

C

C

N

N

C

N

N

N

C

N

C

N

N

N

N

N

N

N

N

I

I

R

C

C

N

N

C

C

C

Meropenem

C

C

N

N

C

N

C

C

C

N

N

I

C

C

I

C

N

C

I

N

C

C

C

N

C

I

C

C

C

Methylprednisolone

C

N

C

C

C

C

C

C

C

C

N

C

C

I

C

C

C

I

C

C

C

C

C

C

I

C

C

C

Metoclopramide

N

C

C

C

C

C

C

C

C

I

N

C

I

C

C

C

N

N

C

N

C

C

C

C

C

C

C

Metronidazole

I

I

N

C

C

C

I

N

N

N

C

I

N

C

N

N

C

N

C

C

N

N

N

N

C

N

Micafungin

C

N

C

C

C

C

C

I

C

C

I

I

C

I

N

N

I

C

C

C

C

I

C

C

C

Midazolam

C

C

C

C

C

C

N

C

C

I

C

C

C

N

C

N

C

C

C

C

N

C

C

C

Morphine sulfate

C

C

C

C

I

C

C

C

I

N

C

C

C

C

C

C

C

C

N

I

N

C

C

Nafcillin

C

C

C

C

N

C

C

I

C

C

C

C

G

C

G

C

C

C

I

C

C

C

Nitroglycerin

C

C

C

N

C

C

I

C

C

I

C

C

C

C

C

C

C

I

C

C

I

Nitroprussidea

C

C

N

C

N

C

C

C

C

C

C

C

C

C

C

C

N

I

C

C

I

C

I

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

C

N

C

C

C

N

C

C

C

C

C

C

C

C

C

C

I

C

C

C

C

C

C

N

C

N

C

N

N

C

C

N

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

N

C

N

I

I

N

N

C

C

N

C

N

N

C

C

C

C

N

C

C

C

N

C

C

C

C

C

N

C

C

N

N

N

C

C

C

C

C

C

C

C

I

C

C

C

C

C

N

C

C

I

C

C

C

C

C

C

N

C

N

C

N

C

C

C

C

N

C

C

C

N

C

C

C

I

C

C

C

C

C

C

N

N

C

N

I

I

I

C

C

C

C

C

C

N

N

N

C

C

C

C

C

I

C

C

C

I

I

I

I

I

I

I

I

I

C

C

C

C

N

I

I

I

C

C

C

C

C

N

C

C

C

C

C

N

N

N

I

I

C

I

C

C

C

C

C

C

C

C

I

N

N

N

C

C

I

G

C

N

C

C

C

C

I

I

C

N

C

C

C

C

C

C

R

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

N

C

C

N

C

C

C

E

I

C

I

I

N

C

I

N

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

I

C

I

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

N

N

N

N

N

C

C

C

N

N

C

C

I

C

C

C

C

C

C

C

I

C

C

C

C

N

N

C

C

N

N

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

C

N

N

C

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

N

C

C

I

C

C

C

N

I

N

N

N

I

N

I

N

I

N

C

N

N

N

I

I

C

C

N

C

C

I

C

C

C

C

C

I

C

C

C

C

I

C

C

C

Norepinephrine

N

I

C

C

I

C

C

C

C

C

I

C

C

C

C

I

C

C

C

Ondansetron

I

N

C

I

C

C

C

C

N

C

C

C

C

C

C

C

C

C

Palonosetron

N

C

I

N

C

I

N

C

N

C

N

C

N

N

N

C

I

Pantoprazoleb

C

I

N

C

C

N

C

N

N

C

N

C

I

N

C

N

Penicillin G

I

C

C

C

N

C

C

C

C

C

C

I

C

C

C

Phenylephrine

I

I

I

I

I

I

I

I

I

I

I

I

I

I

Phenytoin

C

I

N

C

C

C

C

C

I

C

N

C

C

Piperacillin-tazobactam

C

C

C

C

C

C

C

C

I

C

C

C

Potassium chloride

C

C

N

N

C

C

C

I

C

C

N

Prochlorperazine

C

C

N

N

N

I

N

N

N

N

Propofol

N

N

N

C

C

N

C

N

N

Ringer¡¯s, lactated

C

C

C

C

I

N

C

C

Sodium bicarbonate

N

N

C

N

C

N

C

Sodium chloride 0.9%

C

C

N

C

C

C

Tacrolimus

C

C

C

C

N

Tigecycline

I

C

C

C

Tobramycin

I

N

C

TMP-SMX

C

C

Vancomycin

C

Vasopressin

N

C

C

N

C

C

N

N

C

C

C

C

C

C

C

N

N

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

I

I

N

I

I

I

I

I

I

I

I

I

I

I

I

I

I

I

C

C

C

N

C

C

C

N

I

C

N

C

C

C

C

C

N

N

C

I

C

C

C

N

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

N

C

C

N

C

C

C

N

I

C

C

C

I

C

C

C

I

C

C

I

I

C

C

C

C

N

I

I

N

N

N

N

C

C

C

C

C

C

N

N

N

I

N

C

C

N

C

N

I

N

C

N

C

N

C

C

G

C

C

C

N

C

C

C

I

C

C

C

C

C

C

C

I

C

C

C

N

I

N

C

C

C

I

I

C

N

N

C

I

C

C

N

C

N

N

C

N

R

C

C

N

C

C

C

C

G

C

C

C

C

C

N

C

I

C

C

N

N

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

N

C

C

I

C

C

C

N

N

C

N

C

C

C

C

N

C

C

N

C

C

C

C

C

C

C

C

C

N

C

I

C

C

C

N

C

C

N

C

C

C

C

C

N

C

C

C

N

C

C

N

C

C

C

C

C

N

C

C

I

I

C

C

I

C

C

C

C

C

C

N

C

N

I

N

I

I

C

N

I

N

I

I

I

I

I

C

N

I

I

I

C

I

I

N

N

I

N

N

C

I

C

C

C

C

C

C

C

C

C

C

N

C

C

N

C

C

C

C

C

N

N

C

I

N

C

C

N

C

N

C

C

C

C

I

N

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

I

C

C

C

N

N

C

N

C

C

C

N

C

C

C

C

C

C

C

C

C

C

C

C

N

C

C

C

C

I

C

C

C

I

N

C

I

C

C

N

N

N

C

C

C

N

C

C

C

C

d.

N

C

Voriconazole

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

5

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