Lippincott Williams & Wilkins
Overall treatment effect was assessed using Friedman’s test. Pairwise comparisons were assessed using the sign test. Bold p-values indicate statistically significant differences.AUE 0-xh = area under the curve from time zero to x hours post-dose; E max = maximum effect; E min = minimum effect; HMO = hydromorphone immediate release; N = number of subjects; PBO = placebo (fully randomized only ... ................
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