CURRICULUM VITAE
CURRICULUM VITAE
Name: 026078311 Lecturer ZOR TSAFFRIR
Faculty / Department: Life Sciences / Biochemistry
03-640-7192
Home address: KFAR MENACHEM 22, KFAR MENACHEM 79875, Israel
08-858-4684
Date and place of birth: 11/8/66, USA
Date of arrival to Israel: 1967
Military Service: 1985-1988
Marital status and no. of children: married + 2
A. Education
|Period of study |University Name |Subject |Degree |Award Date |
|1998-1991 |The Hebrew University, Jerusalem |Chemistry |B.Sc. |1992 |
| | | |(summa cum laude, 97) | |
|1991-1997 |The Hebrew University, Jerusalem |Biochemistry |Ph.D. |1998 |
| | | |(summa cum laude) | |
B.Sc. Thesis title ("Amirim" outstanding students program) - "photoregulation of enzyme activity in photochromic polymer", grade - 100.
Supervisor – Itamar Wilner
Ph.D. dissertation title - "Development of tools for identification and characterization of guanine nucleotide binding proteins activity".
Supervisor – Zvi Selinger
C. Academic and Professional Experience
1) 1990: Hebrew University, Jerusalem, Israel
Crystallography of a cobalt complex and kinetics of lignad substitution (article #1)
Dept. of Inorganic chemistry
Project student
2) 1990: Hebrew University, Jerusalem, Israel
Photoregulation of enzyme activity in photochromic polymer (articles #2-3)
Dept. of Organic chemistry
"Amirim" outstanding students program – research project
3) 1991: Hebrew University, Jerusalem, Israel
Development of a photo-affinity label for G proteins (article #4)
Dept. of Biological chemistry
Project student
4) October 1991- November 1997: Hebrew University, Jerusalem, Israel
Development of tools for the study of G proteins activity (articles #4-8 & review #1)
Dept. of Biological chemistry
Ph.D. student
5) January 1998 – May 2003: The Scripps Research Institute, La-Jolla, CA, USA
Structural (protein NMR) and biophysical studies of a transcriptional activator: co-activator complex (articles #9-13)
Dept. of Molecular Biology
Post-doctoral fellow
6) June 2003- July 2004: Genomics Institute of the Novartis Foundation, La-Jolla, CA, USA
Regulation of in-vivo TNFα production (continued collaboration leading to articles #14-15)
Dept. of Chemistry
Institute fellow
7) June 2003- July 2004: The Scripps Research Institute, La-Jolla, CA, USA
Regulation of in-vivo TNFα production (continued collaboration leading to articles #14-15)
Dept. of Immunology
Guest scientist
8) August - September 2004: Tel-Aviv University, Tel-Aviv, Israel
laboratory set-up
Dept. of Biochemistry
Visiting Lecturer
9) October 2004 – October 2009 (activity since 4/2005): Tel-Aviv University, Tel-Aviv, Israel
Regulation of cytokine production in macrophages (articles #14-18)
Dept. of Biochemistry
Lecturer
10) November 2009 - now: Tel-Aviv University, Tel-Aviv, Israel
Regulation of cytokine production in macrophages (articles #19-20 +2 submitted +2 in preparation)
Dept. of Biochemistry
Senior Lecturer
D. Active participation in scientific meetings
1993: (poster) Jacques Monod conference on "molecular and cellular biology of guanine nucleotide-binding regulatory proteins", Aussois , France
1994: (poster) Third annual meeting of the Israel society for neuroscience, Eilat, Israel
1995: (poster) Fourth annual meeting of the Israel society for neuroscience, Eilat, Israel
1996: (poster) Jacques Monod conference on "molecular and cellular biology of ras-like and heterotrimeric G proteins", Aussois, France
1996: (poster) Gordon conference on "Biocatalysis", NH, USA
2000: (lecture) EMBO fellows meeting, Heidelberg, Germany
2001: (lecture) International society of magnetic resonance (ISMAR), Rhodes, Greece
2005: (poster) Keystone symposium on "cytokines, Disease and Therapeutic Intervention", Santa-Fe, NM
2006: (lecture) Annual meeting of the Israeli Club for Magnetic Resonance, Tel-Aviv, Israel
2008: (posters) 5'th congress of the federation of Israel Societies for Experimental Biology, Eilat, Israel
2008: (poster) 15'th Inflammation Research Association (IRA) conference, Chantilly, VA, USA
2008: (lecture) 7'th Sphingolipid club conference, Leiden, Netherlands
2009: (posters) Israel Immunological Society 37'th annual meeting
2009: (lecture) 5'th Charleston ceramide conference, Charleston, SC, USA
2010: (lecture) 8'th Sphingolipid club conference, Glasgow, UK
2010: (lecture) 51'th International Conference on the Bioscience of Lipids, Bilbao, Spain
E. Academic and professional awards
E.1 Internal grants (at TAU)
|Year |Foundation |Title |Sum |Status |
|2006 |TAU Research Authority |High score in the ISF grant |19,000 NIS (~$4,400) |PI |
|2008 |TAU Research Authority |High score in the BSF grant |27,000 NIS (~$7,500) |PI |
|2009 |TAU Research Authority |High score in the ISF grant |21,000 NIS (~$5,600) |PI |
E.1.2 External grants
|Year |Foundation |Title |Sum |Status |
|2005 |European Commission FP6 – Marie Curie |Mechanism of anti-inflammatory activity of a |80,000 euro |PI |
| |IRG |phospholipid-like drug |(~$100,000) | |
|2006 |Teva Pharm. Ind. Ltd. – |A phospholipid-dependent anti-inflammatory signal |50,000 NIS |PI |
| |Young investigators grant for research |transduction pathway in macrophages |(~$12,000) | |
| |of auto-immune diseases | | | |
|2007 |Public committee for allocation of |Mechanism of TNFα suppression and anti-inflammatory |200,000 NIS |PI |
| |Estate funds at Israel's ministry of |activity of a phospholipid-like drug |(~$48,000) | |
| |justice | | | |
|2007 |Israel Science Foundation (ISF) |A phospholipid-dependent anti-inflammatory signal |326,000 NIS |PI |
| | |transduction pathway in macrophages |(~$82,000) | |
|2007 |Israel Science Foundation (ISF) |equipment for a new lab |$65,000 |PI |
|2007 |Wolfson Foundation |equipment for a new lab |154,878 pound (~$310,000) |PI |
|2010 |Health ministry of Israel |Identification and characterization of |300,000 NIS |PI |
| | |inflammation-linked receptors for C1P and for its |(~$80,000) | |
| | |analog PCERA-1 | | |
E.2 Fellowships (competitive)
1992-3: Excellence fellowship for M.Sc. students
1997: Rothschild post-doctoral fellowship
1997-9: EMBO post-doctoral fellowship
E.3 Scholarships
1989-1991: Scholarship of the "Amirim" outstanding B.Sc. students program
1996: Katzir travel award for Ph.D. students
2001: ISMAR scholarship for conference lecture
E.4 Prizes
1989: a) Dean's prize for BSc. students in the science faculty
b) Excellence prize - "De-Shalit" chemistry summer school (Weizmann Institute)
1990: Dean's list of the science faculty
1991: Petai prize for five top B.Sc. graduates in the science faculty
1992: a) B.Sc. conferred with "summa cum laude"
b) Rector's prize for M.Sc. students in the science faculty
1994: Landow prize for Ph.D. students
1997: Best poster in the life sciences institute posters contest
1998: Ph.D. conferred with "summa cum laude"
2001: Best poster in the Scripps research institute society of fellows posters contest
2009: Best poster in the Israel Immunological Society meeting (presented by my student)
F. Membership in professional societies
2005-present: Israel Society for Biochemistry & Molecular Biology (ISBMB, Israel)
2008-present: The sphingolipid club (International)
G. Doctoral students supervised (all at TAU)
1) October 2004-August 2010: Dorit Avni
Subject: Regulation of cytokine production in LPS-activated macrophages by PCERA-1
Thesis title: Regulation of TNFα and IL-10 production in LPS-activated macrophages by the cAMP and NFκB p50 pathways
2) October 2004-December 2009: Meir Goldsmith
Subject: Regulation of cytokine and PGE2 production in macrophages by PCERA-1
Thesis title: Identification and characterization of TNFα suppression mechanism by the phospholipid-like molecule PCREA-1
3) October 2006-present (Direct Ph.D. program): Orna Ernst
Subjects: 1) Regulation of cytokine production in macrophages by PCERA-1
2) Regulation of cytokine production in macrophages by Hsp10
Thesis title: Mechanisms of regulation of LPS-induced IL-10 and TNFα expression by PCREA-1 via the p38 and cAMP pathways.
4) October 2007-present: Yifat Glucksam
Subjects: 1) Regulation of IL-10 transcription in macrophages by PCERA-1
2) Regulation of macrophages activity by CD44 and its ligand Hyaluronan
3) PCERA-1 drug delivery by CD44-targeted bioadhesive liposomes
Thesis title: Modulation of macrophages inflammatory responses by the phospho ceramide analog PCERA-1, and by CD44-targeted bioadhesive liposomes.
M.Sc. students supervised (all at TAU)
1) October 2004- October 2006: Elad Bar-David
Subject: Regulation of cytokine production by a PCERA-1-derived metabolite
Thesis title: Purification and identification of the active metabolite of an anti-inflammatory phospholipid-like molecule
2) October 2005- October 2007: Maya Levi
Subject: Regulation of cytokine production by sphingolipids
Thesis title: Comparison of the putative anti-inflammatory activities of PCERA-1 and C8-C1P
3) October 2006- October 2008: Amir Pri-Or
Subject: Regulation of cytokine production by Hsp10
Thesis title: Characterization of the involvement of the mitochondrial co-chaperonin Hsp10, w.t. and mutant L33A, in macrophages function and in interaction with the chaperonin Hsp60
4) October 2007- October 2009: Amir Philosoph
Subject: Regulation of cytokine production by PCERA-1
Thesis title: From the PCERA-1 receptor via adenylyl cyclase to cytokines modulation
5) October 2008- September 2010: Ala Daka
Subject: Regulation of PGE2 production in macrophages
Thesis title: Inhibition of PGE2 production by a ceramide analog
6) October 2009- present: Shahar Cohen
Subject: Regulation of cytokine production by PCERA-1
Thesis title: to be decided
6) October 2009- present: Sharon Avraham
Subject: Melanocortin1 receptor variability – a link with melanoma risk
Thesis title: to be decided
SCIENTIFIC PUBLICATIONS
B.1. ORIGINAL ARTICLES
Articles published
1) B. Ballet, A. Bino, S. Cohen, H. Rubin, T. Zor
A linear mixed oxidation state trinuclear cobalt complex with six bridging sulfito ligands
Inorganica Chimica Acta, 188, pp. 91-93, 1991
Impact factor – 2.0 Citations – 8
2) Itamar Willner, Shai Rubin and T. Zor
Photoregulation of α-chymotrypsin by its immobilization in a photochromic azobenzene copolymer.
Journal of the American Chemical Society, 113, pp. 4013-4014, 1991
Impact factor – 8.1 Citations – 40
3) I. Willner, S. Rubin, R. Shatzmiller, T. Zor
Reversible light-stimulated activation and de-activation of α-chymotrypsin by its immobilization in photoisomerizable copolymers.
Journal of the American Chemical Society, 115, pp. 8690-8694, 1993
Impact factor – 8.1 Citations – 52
4) T. Zor, I. Halifa, S. Kleinhaus, M. Chorev, Z. Selinger
m-Acetyl Anilido GTP, a novel photoaffinity label for GTP-binding proteins: synthesis and application.
Biochemical Journal, 306, 1, pp. 253-258, 1995
Impact factor – 4.4 Citations – 10
5) T. Zor, Z, Selinger
Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies.
Analytical Biochemistry, 236, pp. 302-308, 1996
Impact factor – 3.1 Citations – 295
6) T. Zor, M. Bar-Yaacov, S. Elgavish, B. Shaanan, Z. Selinger
Rescue of a mutant G-protein by substrate-assisted catalysis.
European Journal of Biochemistry, 249, pp. 330-336, 1997
Impact factor – 3.1 Citations – 22
7) T. Zor, R. Andorn, I. Sofer, M. Chorev, Z. Selinger
GTP analogue hydrolysis by the Gs protein: implication for the role of the catalytic glutamine in the GTPase reaction.
FEBS Letters, 433, pp. 326-330, 1998
Impact factor – 3.3 Citations – 15
8) M.R. Ahmadian*, T. Zor *, D. Vogt, W. Kabsch, Z. Selinger, A. Wittinghofer, K. Scheffzek
GTPase stimulation of oncogenic Ras mutants.
Proceedings of the national Academy of Sciences USA, 96, pp. 7065-7070, 1999
Impact factor – 9.4 Citations – 57
* The first two authors contributed equally to this work.
9) D. Parker, M. Rivera, T. Zor, A. Henrion-Caude, I. Radhakrishnan, A. Kumar, L.H. Shapiro, P.E. Wright, M.R. Montminy, P.K. Brindle
Role of secondary structure in discrimination between constitutive and inducible activators.
Molecular and Cellular Biology, 19, pp. 5601-5607, 1999
Impact factor – 5.9 Citations – 71
10) T. Zor, B.M. Mayr, H.J. Dyson, M.R. Montminy, P.E. Wright
Roles of phosphorylation and helix propensity in the binding of the KIX domain of CBP by constitutive (c-Myb) and inducible (CREB) activators.
Journal of Biological Chemistry, 277, pp. 42241-42248, 2002
Impact factor – 5.5 Citations – 43
11) N.K. Goto*, T. Zor*, M. Martinez-Yamout, H.J. Dyson, P.E. Wright
Cooperativity in transcription factor binding to the coactivator CBP: the MLL activation domain binds to an allosteric site on the KIX domain.
Journal of Biological Chemistry, 277, pp. 43168-43174, 2002
Impact factor – 5.5 Citations – 42
* The first two authors contributed equally to this work.
12) T. Zor, R.N. De Guzman, H.J. Dyson, P.E. Wright
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb.
Journal of Molecular Biology, 337, pp. 521-534, 2004
Impact factor – 4.2 Citations – 41
13) J.L. Best, C.A. Amezcua, B. Mayr, L. Flechner, C.M. Murawsky, B. Emerson, T. Zor , K.H. Gardner, M.R. Montminy
Identification of Small Molecule Antagonists that Inhibit an Activator: Coactivator Interaction.
Proceedings of the national Academy of Sciences USA, 101, pp. 17622–17627, 2004
Impact factor – 9.4 Citations – 35
14) M. Goldsmith, D. Avni, G. Levy-Rimler, R. Mashiach, O. Ernst, M. Levi, B. Webb, M.M. Meijler, N.S. Gray, H. Rosen, T. Zor
A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-α and induces interleukin-10 production in activated macrophages.
Immunology, 127, pp. 103-115, 2009 (E-pub 2008, Sep 11)
Impact factor – 3.4 Citations – 3
15) D. Avni, M. Goldsmith, O. Ernst, R. Mashiach, T. Tuntland, M.M. Meijler, N.S. Gray, H. Rosen, T. Zor
Modulation of TNFα, IL-10 and IL-12p40 levels by a ceramide-1-phosphate analog, PCERA-1, in-vivo and ex-vivo in primary macrophages.
Immunology Letters, 123, pp. 1-8, 2009
Impact factor – 2.9 Citations – 4
16) M. Goldsmith, D. Avni, O. Ernst, Y. Glucksam, G. Levy-Rimler, M.M. Meijler, T. Zor
Synergistic IL-10 induction by LPS and the ceramide-1-phosphate analog PCERA-1 is mediated by the cAMP and p38 MAP kinase pathways.
Molecular Immunology, 46, pp. 1979-1987, 2009
Impact factor – 3.6 Citations – 3
17) M. Levi, M.M. Meijler, A. Gómez-Muñoz, T. Zor
Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1).
Molecular and Cellular Endocrinology, 314, pp. 248-255, 2010
Impact factor – 3.6 Citations – 2
18) D. Avni, A. Philosoph, M.M. Meijler, T. Zor
The ceramide-1-phosphate analog PCERA-1 modulates TNFα and IL-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.
Immunology, 129, pp. 375-385, 2010
Impact factor – 3.4 Citations – 1
19) D. Avni, O. Ernst, A. Philosoph, T. Zor
Role of CREB in modulation of TNFα and IL-10 expression in LPS-stimulated RAW264.7 macrophages.
Molecular Immunology, 47, pp. 1396-1403, 2010
Impact factor – 3.6 Citations – not available yet
20) O. Ernst, T. Zor
Linearization of the Bradford protein assay
Journal of Visualized Experiments, 38, 2010
doi: 10.3791/1918
Impact factor – not available yet Citations – not available yet
21) M. Goldsmith, A, Daka, N.F. Lamour, R. Mashiach, Y. Glucksam, M.M. Meijler, C.E. Chalfant, T. Zor
A ceramide analog inhibits cPLA2 activity and consequent PGE2 formation in LPS-stimulated macrophages.
Immunology Letters, 135, pp. 136-143, 2011–01–23
Impact factor – 2.9 Citations – not available yet
Accepted for publication
Submitted for publication
1) Y. Glucksam, T. Zor, R. Margalit
Targeting regular and hyaluronan-modified liposomes to macrophages and their impact on TNF-α production.
BBA-Biomembranes, submitted
In preparation
1) D. Avni, Y. Glucksam, T. Zor
LY294002 and LY303511 inhibit LPS-induced IL-10 expression in macrophages via NFkB1 (p50).
Expected submission date: November 2010
2) Y. Glucksam, M.M. Meijler, T. Zor
A pseudomonas aeruginosa quorum-sensing signal molecule up-regulates production of the anti-inflammatory cytokine IL-10 in stimulated macrophages.
Expected submission date: December 2010
B.3. REVIEW ARTICLES
1) M. Kosloff, T. Zor, Z. Selinger
Substrate Assisted Catalysis: implications for biotechnology and drug design.
Drug Development Research, 50, pp. 250-257, 2000
Impact factor – 1.4
D.3. ABSTRACTS AND PROCEEDINGS
1) R. Andorn-Broza, I. Sofer, T. Zor, M. Chorev, Z. Selinger
GTP analog hydrolysis by the G(s) protein: Implications for the role of catalytic glutamine in the GTPase reaction.
Neuroscience Letters, Suppl. 51, S2, 1998
2) D. Avni, M. Goldsmith, T. Zor
Synergistic induction of IL-10 by a TLR agonist and a phospho-ceramide analog is mediated by CAMP.
Inflammation Research, 57, S111-S112, 2008
3) M. Goldsmith, D. Avni, M. Levi, O. Ernst, M.M. Meijler, N.S. Gray, H. Rosen, T. Zor
A ceramide-1-phosphate analog, PCERA-1, suppresses TNF alpha and induces IL-10 production in activated macrophages.
Naunyn-Schmiedebergs archives of pharmacology, 380, 4, 364, 2009
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