THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR ...

Vol. 19 / No. 4 / April 2020 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY

The magic isn't the squid...

`` '' The magic is the protein.

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NEWS

FEATUREESS

PERSPEECCTTIIVVEESS

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EDITOR'S NOTE

Caution: Tchotchkes at work

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MEMBER UPDATE

6

IN MEMORIAM

10

RETROSPECTIVE

Marilyn Farquhar (1928 ? 2019)

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LIPID NEWS

A deeper insight into phospholipid biosynthesis in Gram-positive bacteria

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JOURNAL NEWS

14 Scrutinizing pigs' biggest threat 15 Progesterone from an unexpected source

may affect miscarriage risk 16 Finding neoantigens faster -- advances

in the study of the immunopeptidome 18 From the journals

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`THE MAGIC ISN'T THE SQUID ...

The magic is the protein.'

28

`START SIMPLE. IT ALWAYS GETS MORE COMPLICATED.'

A conversation with Paul Dawson

37

USE THE MIC!

38

WHAT CAN YOUR OMBUDS OFFICE DO FOR YOU?

ANNUAL MEETING

32 MOLECULAR & CELLULAR PROTEOMICS SESSION

32

MCP TO HOST PROTEOMICS SESSION

33

GINGRAS STUDIES PROTEOMICS' IMPLICATIONS FOR RESEARCH

34

SELBACH SEEKS THE SCIENCE BEHIND THE MAGIC

35

GARCIA USES MASS SPECTRONOMY TO UNRAVEL THE HUMAN EPIGENOME

28

MARCH 2020

52

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ASBMB TODAY 1

EDITOR'S NOTE

THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY

OFFICERS

Gerald Hart President

Toni M. Antalis President-elect

Wei Yang Secretary

Joan Conaway Treasurer

EX-OFFICIO MEMBERS

Robert S. Haltiwanger Carla Koehler

Co-chairs, 2020 Annual Meeting Program Committee

Cheryl Bailey Chair, Education and Professional Development

Committee

Daniel Raben Chair, Meetings Committee

Sonia Flores Chair, Minority Affairs

Committee

Nicole Woitowich Chair, Science Outreach and Communication Committee

Terri Goss Kinzy Chair, Public Affairs Advisory Committee

Ed Eisenstein Chair, Membership Committee

Susan Baserga Chair, Women in Biochemistry

and Molecular Biology Committee

Sandra Weller Chair, Publications

Committee

Lila M. Gierasch Editor-in-chief, JBC

A. L. Burlingame Editor, MCP

Nicholas O. Davidson Editor-in-chief, JLR

Kerry-Anne Rye Editor-in-chief, JLR

COUNCIL MEMBERS

Suzanne Barbour Joan Broderick Matt Gentry Blake Hill Audrey Lamb James M. Ntambi Takita Felder Sumter Kelly Ten?Hagen JoAnn Trejo

ASBMB TODAY EDITORIAL ADVISORY BOARD

Rajini Rao Chair Ana Maria Barral Natasha Brooks Kelly Chac?n Beronda Montgomery Bill Sullivan Melissa Vaught Binks Wattenberg

ASBMB TODAY

Angela Hopp Executive Editor ahopp@

Comfort Dorn Managing Editor cdorn@

Lisa Schnabel Graphic Designer lschnabel@

John Arnst Science Writer jarnst@

Laurel Oldach Science Writter loldach@

Ed Marklin Web Editor emarklin@

Allison Frick Multimedia and Social Media Content Manager africk@

Barbara Gordon Executive Director bgordon@

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Articles published in ASBMB Today reflect solely the authors' views and not the official positions of the American Society for Biochemistry and Molecular Biology or the institutions with which the authors are affiliated. Mentions of products or services are not endorsements.

2 ASBMB TODAY

Caution: Tchotchkes at work

By Comfort Dorn

_ tchotchke (noun) \'ch?ch-k , -ke; 'ts?ts-k \: knickknack, trinket

e

e

Origin: Yiddish tshatshke trinket, from obsolete Polish czaczko

First Known Use: 1971

--Merriam Webster Unabridged

On my office windowsill I have a plastic margarita glass full of paper umbrellas, a small pot of succulents, a pottery jar wearing a scarf and hat, a plastic butterfly ring, a fidget spinner and a sign that reads "Crazy cat lady." These are my office tchotchkes. They're usually more spread out, but I wanted to pose them:

We all have these things, right? The random objects that accumulate in our workspaces and make them our own. Look around your desk/office/lab. What do you see? You can probably tell a story about where each of these non?work-related things came from -- and that's what I want you to do.

Regular readers might recall that we devote our August issue to the topic of careers. We invite you to submit essays and articles related to your career path, sharing what you've learned. We want to know what works (and what doesn't) as ASBMB members seek and find the jobs that fit.

We still want those serious, useful articles and essays (deadline: June 15), but we also want your tchotchkes.

Take a picture of the knickknacks in your workspace (bonus points if you're in the photo too) and tell us their story: Where did you get them--and when? What do you think about/feel when you look at them?

You don't need to write a lot. Keep it under 100 words. Then send your picture (as a jpg file) and words to asbmbtoday@ by June 15. We'll share them in our August 2020 issue.

Comfort Dorn (cdorn@) is the managing editor of ASBMB Today. Follow her on Twitter @cdorn56.

Correction The data sources for infographics in the story "A Matter of Degree" in the February issue were incorrect. Please refer to the web version of the story at asbmbtoday for correct data citations. In the same article, Zerick Dunbar's school was misidentified; he attends Meharry Medical College in Nashville. Also, Taylor Carmon's compensation from Alabama A&M University was misstated; he is paid a stipend.

MARCH 2020

MEMBER UPDATE

Young researchers present science

The Emerging Researchers National Conference in STEM, hosted by the American Association for the Advancement of Science and the National Science Foundation, is an opportunity for underrepresented undergraduate and graduate students to present their research to peers and professors.

Among this year's presenters were nine student members of the American Society for Biochemistry and

Molecular Biology, along with three faculty members. (See the full list of presenters at our website.)

Stephen Gonzalez, a student at California State University, Fullerton, pictured above, said, "One of the conversations that really stuck with me was with one of my poster judges ... We got into a great talk about my research. I cherished his time there, since he really made me grow more scientifically and as a presenter."

Doudna, Charpentier share Wolf prize in medicine

The 2020 Wolf Prize in medicine will be awarded jointly to Jennifer Doudna and Emmanuelle Charpentier, whose work led to the discovery of the gene-editing tool clustered regularly interspaced short palindromic repeats?CRISPR-associated protein 9, or CRISPR?Cas9.

Doudna is the Li Ka Shing chancellor's chair in biomedical and health sciences and a professor of molecular and cell biology and professor of chemistry at the University of California, Berkeley, and a Howard Hughes Medical Institute investigator. She studies how RNA molecules control the expression of genetic information. In 2013, Doudna won the American Society for Biochemistry and Molecular

Biology's inaugural Mildred Cohn Award in Biological Chemistry.

Charpentier is a biochemist, microbiologist and geneticist recognized as an expert in regulatory mechanisms underlying processes of infection and immunity in bacterial pathogens. She is scientific and managing director of the Max Planck Unit for the Science of Pathogens in Berlin, an institute that she founded with the Max Planck Society.

Doudna and Charpentier determined the mechanism of RNA-guided bacterial adaptive immunity by the CRISPR-Cas9 system, enabling them to harness the system for efficient genome engineering in animals and plants.

This is the 42nd year the Wolf

Doudna

Charpentier

Foundation will award the Wolf Prize "to outstanding scientists and artists from around the world ... for achievements in the interest of mankind and friendly relations among peoples," according to the foundation's website. Wolf Prizes are given in art, agriculture, physics, medicine and mathematics. A New York Times article noted that the Wolf Prize is thought of as one of the predictors of a future Nobel Prize.

MARCH 2020

ASBMB TODAY 3

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