Curriculum Vitae - KSU



Curriculum Vitae

Ebtehal s. al Abdullah

Ebtehal S. Al Abdullah, Ph.D.

Associate professor.Pharm.Chem. Dept.

Faculty of pharmacy,King Saud University,

Women Student-Medical studies&Sciences Sections

P.O.Box 22452,Riyadh - 11495,Saudi Arabia

Education

|May 2007 |PhD degree in Pharmaceutical Chemistry. King Saud University, Riyadh, Saudi Arabia |

|January 2000 |Master Degree in Pharmaceutical Chemistry, School of Pharmacy. King Saud University, Riyadh, |

|  |Saudi Arabia |

|May 1994 |Bachelor' Degree in Pharmaceutical Sciences. School of Pharmacy, King Saud University. Riyadh, |

|  |Saudi Arabia |

| |

|Professional Work Experience: |

|Oct.2011 - 2015 As vice head of pharmaceutical chemistry department, Pharmacy |

|College |

|Sep. 2008 – 2009 | AS Head of ad administrative and financial unit in pharmacy college |

|April 2012- present |Teaching at the Pharmaceutical Chemistry Department, School of Pharmacy, as associate professor |

| |. |

|Sep. 2007- 2012 |Teaching at the Pharmaceutical Chemistry Department, School of Pharmacy, as assistant professor |

|2006- 2007 |. |

| |Teaching at the Pharmaceutical Chemistry Department, School of Pharmacy, as lecturer |

|1994-2006 |Teaching at the Pharmaceutical Chemistry Department, School of Pharmacy, as teaching assistant. |

| |This included teaching practical laboratory courses for undergraduate pharmacy students. |

|Special Projects: |

|1995-2000 |Master Thesis Project: Synthesis of new sulfonylureas as potential anticancer agents |

|2001 |Participation in King Adulaziz city for science and technology funded projects in the department|

| |of pharmaceutical chemistry. |

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|2003-2007 | |

| |PhD thesis project : Synthesis and biological testing of new 1-adamantyl derivatives |

|Conferences & Training workshops:|Cordial scientific and technical contribution in Computer Aided Learning Programs for Teaching &|

| |Research workshop held in 8,9 April2003 in KSU. |

| |Attendance of workshop Formation Training for New Faculty member held in 28-30/10/2007. |

| |Attendance of First workshop to SWOT analysis for Faculty members for Strategic Planning Project|

| |of KSU held in 16/3/2008 |

| |Attendance of workshop Innovative Assessment Writing High Quality MCQ Items held in 7/5/2008 |

| |Attendance of workshop of Quality System Planning in High Education held in 24-28/5/2008. |

| |Attendance of workshop Waters LC\MS\MS Operation and Application Training Course held in |

| |26/10/2008. |

| |Attendance of workshop Active learning held in 28,29/11 &1/12/2008 |

| |Attendance of workshop of How to Manage the Time held in 23-24/12/2008. |

| |Attendance of workshop of Strategic Planning held in 26-27/1/2009. |

| |- Evaluation of the Performance of Students Skills held on11/1430 |

| |- course protifolio held on 14-15\12\2009 |

| |- Learning Based Brainstorming held in 12-13/10/2010 |

| |- Learning through proplem solving, held on 8- 9/01/2011 |

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|Publications: | |

1- Synthesis of Certain Diarylsulfonylureas as Antitumor Agents , Khairia M.Youssef , Ebtihal Al-Abdullah and Hammad El-Khamees. Med.Chem.Res.10:6 (2001)404-418.

2- Synthesis of Sulofenur Analoges as Antitumour Agents : part II . Khairia M.Youssef , Ebtihal Al-Abdullah and Hammad El-Khamees. Med.Chem.Res.11:9 (2002)481-503.

3- Microwave-Assisted dehydrosulfurilation : an efficient , solvent free synthesis of 5-(1-adamantyl)-2-arylamino-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. Ebtehal S. Al-Abdullah, Ihsan A. Shehata, Omar A. Al-Deeb, and Ali A. El-Emam. Heterocycles,.71:2(2007)379-388.

4- Synthesis, radiochemical and biological characteristics of 99mTc-8-hydroxy-7-substituted quinoline complex: a novel agent for infection imaging). M. A. Motaleb, E. S. Alabdullah and W. A. Zaghary. Journal of Radioanalytical and Nuclear Chemistry 287: 1, (2011) 61-67

5- Synthesis, Antimicrobial, and Anti-inflammatory Activities of Novel 5-(1-Adamantyl)-4-arylideneamino-3-mercapto-1,2,4-triazoles and Related Derivatives Mohamed A. Al-Omar, Ebtehal S. Al-Abdullah, Ihsan A. Shehata, Elsayed E. Habib,Tarek M. Ibrahim and Ali A. El-Emam Molecules,15( 2010) 2526-2550; doi:10.3390/molecules15042526

6- Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives. Adnan A. Kadi, Ebtehal S. Al-Abdullah, Ihsan A. Shehata, Elsayed E. Habib, Tarek M. Ibrahim, Ali A. El-Emam European Journal of Medicinal Chemistry 45 (2010) 5006-5011.

7- Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents. Ebtehal S. Al-Abdullah, Abdul-Rahman M. Al-Obaid, Omar A. Al-Deeb ,Elsayed E. Habib, Ali A. El-Emam. European Journal of Medicinal Chemistry 46 (2011) 4642-4647.

8- Synthesis and Anticancer Activity of Some Novel Tetralin-6-yl-pyrazoline, 2-Thioxopyrimidine, 2-Oxopyridine, 2-Thioxo-pyridine and 2-Iminopyridine Derivatives. Ebtehal S. Al-Abdullah. Molecules,16 ( 2011) 3410-3419; doi:10.3390/molecules16043410

9- Design and Synthesis of Acridine-4-Carboxamide and Acridine-4- Carboxylate Derivatives as Tyrosine Kinase Inhibitors. Gehan H.Hegazy, Maha S. Almutairi, Ebtehal S. Al Abdullah. Life Science Journal,8:3 (2011)192-198.

10- Dr. Ebtehal S. Al-Abdullah, Gatifloxacin. In Harry Brittain, editors: Profiles of Drug Substances, Excipients and Related Methodology, 37, PODRM, UK: Academic Press, 2012, pp. 183-244.

11- 3-(Adamantan-1-yl)-1-[(4-benzylpiperazin-1-yl)methyl]-4-phenyl-1H-1,2,4-triazole-5(4H)-thione. Ebtehal S. Al-Abdullah, Hanadi H. Asiri, Ali El-Emam,and Seik Weng Ng. Acta Cryst. E68 (2012) o344

12- Ethyl 4-{[3-(adamantan-1-yl)-4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazine-1-carboxylate. Ebtehal S. Al-Abdullah, Hanadi H. Asiri, Ali A. El-Emam and Seik Weng Acta Cryst E68. (2012) o531

13- 3-(Adamantan-1-yl)-4-phenyl-1-[(4-phenylpiperazin-1-yl)methyl]-1H-1,2,4-triazole-5(4H)-thione. Ebtehal S. Al-Abdullah, Hanadi H. Asiri, Ali El-Emam and Seik Weng Ng Acta Cryst. E68 (2012) o345.

14- 3-(Adamantan-1-yl)-4-ethyl-1-[(4-phenylpiperazin-1-yl)methyl]-1H-1,2,4-triazole-5(4H)-thione. Ali A. El-Emam, Ebtehal S. Al-Abdullah, Hanaa M. Al-Tuwaijri,a Mohammed Said-Abdelbakyb and SantiagoGarcı´a-Granda. Acta Cryst. E68 (2012) o2380–o2381.

15- 3-(Adamantan-1-yl)-4-[(E)-(2,6-difluorobenzylidene)amino]-1-[(4-phenylpiperazin-1-yl)methyl]-1H-1,2,4-triazole-5(4H)-thione. Ali A. El-Emam, Ebtehal S. Al-Abdullah, Nasser R.El-Brollosy, Seik Weng Ngb, and Edward R. T. Tiekink. Acta Cryst. E68 (2012) o2031.

16- 5-(Adamantan-1-yl)-3-(benzylsulfanyl)-4-methyl-4H-1,2,4-triazole. Ebtehal S. Al-Abdullah, Ali A. El-Emam, Hazem A. Ghabbour, Suchada Chantrapromma and Hoong-Kun Fun. Acta Cryst. E68 (2012) o2427–o2428

17- 5-(Adamantan-1-yl)-3-[(2-methoxyethyl)sulfanyl]-4-phenyl-4H-1,2,4-triazole Ali A. El-Emam, Ebtehal S. Al-Abdullah, Hanadi H. Asiri, Suchada Chantrapromma and Hoong-Kun Fun Acta Cryst. E68 (2012) o2326

18- Synthesis, Molecular Docking and Preliminary in-Vitro Cytotoxic evaluation of Some Substituted Tetrahydronaphthalene (2',3',4',6'-Tetra-O-Acetyl-β-D-Gluco-/Galactopyranosyl) Derivatives Maha S. Al-Mutairi , Ebtehal S. Al-Abdullah , Mogedda E. Haiba, Mohammed A. Khedr and Wafaa A. Zaghary Molecules Molecules, 17(2012) 4717-4732.

19- 3-(Adamantan-1-yl)-4-[(E)-(2,6-difluorobenzylidene) amino]-1-[(4-ethylpiperazin-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione. Abdul-Malek S. Al-Tamimi, Ebtehal S. Al-Abdullah,Ali A. El-Emam, Seik Weng Ngd and Edward R. T.Tiekink Acta Cryst. E69 (2013) o685.

20- Synthesis and Cytotoxicity of Some New Substituted Hydronaphthalene Derivatives. Mogedda E Haiba, Ebtehal S Al-Abdullah and Noha Mohamed Hilmy. American Chemical Science Journal 3:3(2013)203-220.

21- Synthesis of Some New Substituted Tetrahydronaphthalene Compounds of Effective Antimicrobial Activity. Mogedda E Haiba, Ebtehal S Al-Abdullah, Manal M. Anwar, Ghada E. A. Awad. International Journal of Pharmaceutics, ISSN: 2051-5782, Vol.29, Issue.1, 1113-1127.

22- Pyrimidine-5-carbonitriles – part III: synthesis and antimicrobial activity of novel 6-(2-substitutedpropyl)-2,4-disubstituted pyrimidine-5-carbonitriles. Omar A. Al-Deeb, Abdulghafoor A. Al-Turkistani, Ebtehal S. Al-Abdullah, Nasser R. El-Brollosy, Elsayed E. Habib and Ali A. El-Emam. Heterocycl. Commun. 19:6(2013) 411–419.

23- Vibrational spectroscopy of N'-(Adamantan-2-ylidene)thiophene-2-carbohydrazide, a potential antibacterial agent. Lev L. Gladkov, Sergey V. Gaponenko, Elena V. Shabunya-Klyachkovskaya, Anna N. Shimko, Ebtehal S. Al-Abdullah, Ali A. El-Emam. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 128 (2014) 874–879

24- Use of vibrational spectroscopy to study 4-benzyl-3-(thiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thione: A combined theoretical and experimental approach. Yusuf Sert , Ali A. El-Emam, Ebtehal S. Al-Abdullah, Abdul-Malek S. Al-Tamimi, Çağrı Çırake, Fatih Ucun. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 126 (2014) 280–290.

25- Unusual Sulfuric Acid-Induced Thiol Oxidation on Dehydrative Cyclization of Potassium N′-(1-Adamantylcarbonyl)Dithiocarbazate at Room Temperature. Amer M. Alanazi, Ebtehal S. Al-Abdullah, Nasser R. El-Brollosy, and Ali A. El-Emam. Phosphorus, Sulfur, and Silicon, 189(2014)477–482.

26- Synthesis, Antimicrobial and Anti-inflammatory Activities of Novel S- and N-Substituted-5-(1-adamantyl)-1,2,4-triazole-3-thiols, Ebtehal S. Al Abdullah, Hanadi H. Asiri, Siham Lahsasni, Elsayed E Habib, Tarek M Ibrahim, Ali A. El Emam. Drug Design, Development and therapy 8(2014) 505-518.

27- 3-(Adamantan-1-yl)-4-ethyl-1-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1H-1,2,4-triazole-5(4H)-thione. Ali A. El-Emam, Hanaa M. Al-Tuwaijri, Ebtehal S.Al-Abdullah, C. S. Chidan Kumar and Hoong-Kun Fun. Acta Cryst. E70 (2014) o25–o26

28- Pyrimidine-5-carbonitriles II*: Synthesis and antimicrobial activity of novel 6-alkyl-2,4-disubstituted pyrimidine-5- carbonitriles. Ebtehal S. alAbdullah, A.A.Al turkistani, O.A. al Deeb, N.R. El-Brollosy, E.E. Habib, A.A. El emam. Drug Research 64(2014)31-39.

29- FT-IR and FT-Raman spectroscopic signatures, vibrational assignments, NBO, NLO analysis and molecular docking study of 2-{5-(adamantan-1-yl)-4-methyl-4H-1,2,4-triazol-3-yl}sulfunyl}-N,N-dimethylamine.Maha S. Almutari, Amer A. Alanazi, Ebtehal S. Al Abdullah, Ali A. El-Emam, Shilendra K. Pathak, Ruchi Srivatava, Onkar Prasad, Leena Sinha. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 140 (2015) 1-14

30- Vibrational spectroscopic studies (FT-IR, FT-Raman) and quantum chemical calculations on 5-(Adamantan-1-yl)-3-[(4-fluoroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione, a potential chemotherapeutic agent, Ebtehal S. Al-Abdullah, Sr.S.H.Roseline Sebastian, Reem I. Al-Wabli, Ali A. El-Emam, C.Yohannan Panicker, Christian Van Alsenoy . Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 133 (2014) 605–618.

31- N-(Adamantan-1-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbothioamide. Ali A. El-Emam,a‡Ebtehal S. Al-Abdullah, Hanaa M.Al-Tuwaijri, C. S. Chidan Kumarb and Hoong-Kun Funa. Acta Crystallographica, E69 ( 2013) o1815.

32- Antimicrobial and Hypoglycemic Activities of Novel N-Mannich Bases Derived from 5-(1-Adamantyl)-4-substituted-1,2,4triazoline-3-thiones. Ebtehal S. Al-Abdullah, Hanaa M. Al-Tuwaijri, Hanan M. Hassan, Mogedda E. Haiba, Elsayed E. Habib and Ali A. El-Emam. International Journal of Molecular Sciences, 15(2014) 22995-23010.

33- Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives. Ebtehal S. Al-Abdullah, Hanaa M. Al-Tuwaijri, Hanan M. Hassan, Monirah A. Al-Alshaikh, Elsayed E. Habib and Ali A. El-Emam. Molecules 20(2015) 8125-8143.

34- Synthesis and Characterization of Some Substituted 3, 4-dihydro naphthalene Derivatives through Different Enaminones as Potent Cytotoxic Agents. M.E Haiba, E.S. Al Abdullah, M.M. Edrees, N.M. Khalifa. Drug Research 65(2015) 9-17.

35- Spectroscopic (FT-IR, FT-Raman, and UV–visible) and quantum chemical studies on molecular geometry, Frontier molecular orbitals, NBO, NLOand thermodynamic properties of 1-acetylindole. Vikas K. Shukla, Ebtehal S. Al-Abdullah, Ali A. El-Emam, Alok K. Sachan, Shilendra K. Pathak , Amarendra Kumar, Onkar Prasad, Abha Bishnoi , Leena Sinha. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 133 (2014) 626–638.

36- Theoretical investigations on the molecular structure, vibrational spectra, HOMO–LUMO analyses and NBO study of 1-[(Cyclopropylmethoxy) methyl]-5-ethyl-6-(4-methylbenzyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione. Ebtehal S. Al-Abdullah, Y. Sheena Mary, Yohannan Panicker , Nasser R. El-Brollosy, Ali A. El-Emam, Christian Van Alsenoy , Abdulaziz A. Al-Saadi. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 133 (2014) 639–650.

37- 3-(Adamantan-1-yl)-1-[(4-benzylpiperazin-1-yl)methyl]-4-ethyl-1H-1,2,4-triazole-5(4H)-thione. Ebtehal S. Al-Abdullah, Hanaa M. Al-Tuwaijri,, Ali A.El-Emam, C. S. Chidan Kumar and Hoong-Kun Fun, Acta Crystallographica, E69 ( 2013), o1813–o1814.

38- Crystal structure of 1-(adamantan-1-yl)-3-(4-chlorophenyl) thiourea, C17H21ClN2S. Fatmah A. M. Al-Omary, Hazem A. Ghabbour, Haitham AlRabiah, Ebtehal S. Al-Abdullah, and Ali A. El-Emam. Z. Kristallogr. NCS 2016; aop

39- Crystal structure of N0-(adamantan-2-ylidene)-isonicotinohydrazide, C16H19N3O. Ebtehal S. Al-Abdullah, Hazem A. Ghabbour, Maher M. Al-Jabal, Hoong-Kun Fun and Ali A. El-Emam. Z. Kristallogr. NCS 2016; 231(1): 273–275

40- Structural and spectroscopic characterization of N’-[(1E)-(4-flurophenyl) methyledene]thiophene-2-carbohydrazide, a potential precursor to bioactive agents AGENTS. Monirah A. Al-Alshaikh, S. Muthu, Ebtehal S. Al-Abdullah, E. Elamurugu Porchelvi, Siham Lahsasni, Ali A. El-Emam. Macedonian Journal of Chemistry and Chemical Engineering ( accepted under publication)

41- Raman, infrared and DFT studies of N′-(adamantan-2-ylidene) benzo hydrazide, a potential antibacterial agent. Maksim B. Shundalau, Ebtehal S. Al-Abdullah, Elena V. Shabunya-Klyachkovskaya, Anton V. Hlinisty, Omar A. Al-Deeb, Ali A. El-Emam, Sergey V. Gaponenko. Journal of Molecular Structure Volume 1115, 5 July 2016, Pages 258–266

42- Crystal structure of 5-ethyl-6-[(3-methylphenyl)sulfanyl]pyrimidine-,4(1H,3H)-dione,C13H14N2O2S. Reem I. Al-Wabli, Hazem A. Ghabbour, Siham Lahsasni, Ebtehal S. Al-Abdullah and Ali A. El-Emam. Z. Kristallogr. NCS 2016; aop

|Attending and Publication in conferences |

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|Synthesis of Certain Fused Thiophenes of expected Topoisomerase I and II Inhibitors: Ebtehal S. Al-Abdullah, Maha S. |

|Al-Mutairi, Ihsan Ahmad Shehata.*Presented in Part at the 3ed International Conference of Drug Discovery and Therapy held in |

|Dubai, United Emirates on 7-10-Febroury 2011. |

|Attending 5th International Conference on Drug Discovery and Therapy. February 18-21th , 2012, Dubai, UAE |

|Attending Click chemistry symposium held Nottingham, United kingdom on June 15-17th, 2012 |

|"Synthesis and evaluation of a novel 99mTc-shikonin as a potential tumor imaging agent and in-vitro antitumor activity of |

|shikonin dioxime" M. A. Motaleb, N. M. Al-Musayeib, E. S. Al-abdullah, H. A. Shweeta, W. A. Zaghary. *presented in 34th |

|EORTC-PAMM-BACR meeting, Cardiff, Wales, UK. 23-26 January 2013. |

|Synthesis, Molecular Docking and Preliminery in vitro cytotoxic Evaluation of some Subistituted Terrahydronaphthaene |

|(2’,3’,4’,6’,-tetra-O-Acetyl-B-D-Gluco-/Galactopyranosyl) Derivatives: Maha Al-Mutairi, Ebtehal S. Al Abdullah, Mogedda E. |

|Haiba, Mohamad A. Khedr, Wafaa A. Zaghary * presented in Drug Discovery and selection “ When Chemical Biology meets Drug |

|design” held in Nice, France on July 3-5th, 2013 |

|Attending the Global Sustainable Chemistry & Engineering Event |

|Congress Center Basel, Switzerland, November 11-13th, 2013 |

|Synthesis and Cytotoxic of some new substituted Hydro -naphthalene Derivatives: Mogedda E Haiba, Ebtehal S. AlAbdullah, Noha |

|M. Hilmy * presented in part of Drug Discovery Innovations held in Berlin, Germany on March 18-19th, 2014. |

|Attending The 2014 RACI Congress in Adalid, Austuralia in 7-12 December 2014 |

|Synthesis and Characterization of Some Substituted 3, 4-dihydronaphthalene Derivatives through Different Enaminones as Potent|

|Cytotoxic Agents: M. E. Haiba, Ebtehal. S. Al-Abdulla, M. M. Edrees, N. M. Khalifa. Presented in Fourth International |

|Conference on Multifunctional, Hybrid and Nanomaterials (Hybrid Materials 2015) Sitges (near Barcelona), Spain | 9 - 13 March |

|2015. |

|Synthesis, Antimicrobial and Anti-inflammatory Activities of Novel S- and |

|N-Substituted-5-(1-adamantyl)-1,2,4-triazole-3-thiols, Ebtehal S. Al Abdullah, Hanadi H. Asiri, Siham Lahsasni, Elsayed E |

|Habib, Tarek M Ibrahim, Ali A. El Emam * Presented in Part at “Spanish-Italian Medicinal Chemistry Congress” (SIMCC-2015) held|

|in Barcelona /Spain on July 12-15, 2015. |

|Antimicrobial and Hypoglycemic Activities of Novel N-Mannich Bases Derived from |

|5-(1-Adamantyl)-4-substituted-1,2,4triazoline-3-thiones. Ebtehal S. Al-Abdullah, Hanaa M. Al-Tuwaijri, Hanan M. Hassan, |

|Mogedda E. Haiba, Elsayed E. Habib and Ali A. El-Emam. * Presented in Part at “16th Tetrahedron Symposium Asia Edition 2015 |

|.  held in Shangahi, China on November 10-13, 2015". |

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|Supervision of Theses: |

|Pharmaceutical Chemistry Department. College of Pharmacy – King Saud University |

|"Synthesis of new 5-membered heterocyclic derivatives carring 1-adamantyl substituents of possible antimicrobial, antiviral or|

|anti-inflammatory activity. By Hanadi H. Asiri 2013 " |

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|Pharmaceutical Chemistry Department. College of Pharmacy – King Saud University "Synthesis of new adamantane derivatives of |

|antimicrobial and/or hypoglycemic activities. By Hanaa M. Al-Tuwaijri 2014 " |

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|Chemistry Department. College of Science – King Saud University |

|"Synthesis and antimicrobial activity of some heterocycles compounds containing Thiophene moiety. By Zainab S. Al-Ghamdi 2015|

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|Pharmaceutical Chemistry Department. College of Pharmacy – King Saud University "Synthesis of new coumarine derivatives of |

|possible antioxidant, anti-inflammatory or antimicrobial activities. By Hanan M. Al-Sheble 2016 till now " |

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