New Zealand Practice Guidelines for Opioid Substitution ...

Methadone can be commenced 24 hours after the last dose of buprenorphine. Although the first dose of methadone should not exceed 40 mg, it may be appropriate to provide an initial dose of up to 60 mg if a client is transferring from buprenorphine doses above 12 mg per day (Gowing et al 2013). ................
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