Research.medicine.umich.edu
The University of Michigan Medical School’s MMS Central Biorepository (UMMS CBR) is state-of-the-art research infrastructure with a mission to facilitate discovery and improve healthcare outcomes by providing high quality, highly annotated biospecimens donated for basic, clinical and translational research.??built to support and optimize the standardized collection, processing, storage and distribution of human biological specimens and associated clinical data for University of Michigan biomedical researchers. The CBR is accredited by the College of American Pathologists Biorepository Accreditation Program. The repository is populated through CBR partnerships with investigators, departments, centers, and institutes, who collect biospecimen resources for their own research, and commit to sharing samples for additional, approved research uses. Michigan Medicine patients enrolled in CBR programs provide consent for broad use of biospecimens, as well as controlled access to clinical data contained within the electronic health record. Biorepository processes are included in a quality management system (QMS) to ensure maintenance of specimen integrity for the duration of the storage. The QMS includes version-controlled standardized operating procedures, scheduled and documented equipment calibration and maintenance, internal audit procedures, information systems backups, and personnel training programs with competency testing. Sample chain of custody is secured and tracked throughout the life cycle of the biospecimen using barcodes and a commercially available laboratory information management system (LIMS) tailored to meet UMMS needs. Frozen samples are stored in monitored and alarmed liquid nitrogen vapor phase cryogenic freezers, and -80oC mechanical freezers. Liquid nitrogen is supplied through on-demand from an external bulk-tanks and plumbed into each storage unit, including the -80os, where it serves as a back-up cooling mechanism. Mechanical freezers, temperature monitoring devices, and other key equipment are connected to the emergency power grid, powered by two diesel-fired generators. In addition to storage, Bbiorepository services include sample aliquotting, DNA and RNA isolation and aliquotting, , nucleic acid quantification, and sample distribution management. The Central Biorepository LIMS, securely integrates with a research data warehouse containing detailed clinical information sourced from the electronic health record. This connection allows University of Michigan faculty to interrogate the biorepository and discover samples of interest from a research-specific, clinically-defined cohort of individuals. Access to biospecimens and associated data is subject to regulatory and biorepository oversight approval.(Vici.. I would add a bit about how your operation is integrated with DataDirect (or data warehouse) to facilitate the smooth acquisition of electronic health records for a robust interrogation of stored tissue with patient data. The latter requires regulatory and operational approvals according to set biorepository and University of Michigan policies. Additional services are developed as needed by investigators, and subject to process verification. The UMMS Central Biorepository and lab occupies 4,200 sq.uare feet. , comprising a 2,200 sq. ft. freezer storage space and 2,000 sq. ft. wet lab. Access to the labs is controlled, where entrance to the wet lab requires a key-code and the freezer facility is badged-entry only. and hasThe CBR has current capacity for up to 1,200,000 biological samples in 2 ml tubes. Use of the biorepository and its service is on a fee-for-service recharge basis. ................
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