Nitro-fatty acids: New drug candidates for chronic ...

Accepted Manuscript

Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases Francisco J. Schopfer, Dario A. Vitturi, Diane K. Jorkasky, Bruce A. Freeman

PII: DOI: Reference:

S1089-8603(18)30127-7 10.1016/j.niox.2018.06.006 YNIOX 1802

To appear in: Nitric Oxide

Received Date: 2 May 2018 Revised Date: 20 June 2018 Accepted Date: 22 June 2018

Please cite this article as: F.J. Schopfer, D.A. Vitturi, D.K. Jorkasky, B.A. Freeman, Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases, Nitric Oxide (2018), doi: 10.1016/ j.niox.2018.06.006.

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ACCEPTED MANUSCRIPT

ACCEPTED MANUSCRIPT

Nitro-Fatty Acids: New Drug Candidates for Chronic Inflammatory and Fibrotic Diseases

Francisco J. Schopfer1*, Dario A. Vitturi1, Diane K. Jorkasky2 and Bruce A. Freeman1* 1 Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. 2 Complexa Inc. Berwyn, PA, USA * Correspondence: Bruce A. Freeman (Email: freerad@pitt.edu), Francisco J. Schopfer (Email: fjs2@pitt.edu) Running title: Nitro-fatty acid drug development

Keywords: Nitroalkene, nitro-fatty acid, electrophiles, clinical trial, preclinical development, bardoxolone-me, dimethyl fumarate, Nrf2, Nf-kB, fibrosis, inflammation.

Abbreviations: NO2-OA, nitro-oleic acid; NO2-FA, nitro-fatty acid; CXA-10, 10-nitro-oleic acid (10-nitro-octadec-9-enoic acid), DMF, dimethyl fumarate, MMF (monomethylfumarate); NF-B, nuclear factor B; Nrf2, nuclear factor (erythroid-derived 2)-like 2; HSF-1, heat shock factor 1; LDL-C, low density lipoprotein cholesterol; prostaglandin reductase-1 (PtGR-1); polyethylene glycol-400 (PEG-400); monocyte chemotactic protein-1 (MCP-1)

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