The Journal of PHARMACOLOGY

The Journal of

PHARMACOLOGY

And Experimental Therapeutics

A Publication of the American Society for Pharmacology and Experimental Therapeutics

June 2019

Contents

Vol. 369, No. 3

Downloaded from jpet. at ASPET Journals on January 5, 2023

MINIREVIEWS

Perspectives on Wnt Signal Pathway in the Pathogenesis and Therapeutics of Chronic Obstructive Pulmonary Disease

473

Jiao Qu, Li Yue, Jian Gao, and Hongwei Yao

CARDIOVASCULAR

The Supplement Adulterant b-Methylphenethylamine Increases Blood Pressure by Acting at Peripheral Norepinephrine

328

Transporters

Charles W. Schindler, Eric B. Thorndike, Kenner C. Rice, John S. Partilla, and Michael H. Baumann

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

S Effects in Cancer Cells of the Recombinant L-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation

489

in Human Erythrocytes for Sustained L-Methionine Elimination

David Machover, Luigia Rossi, Jocelyne Hamelin, Christophe Desterke, Emma Goldschmidt, Bernadette Chadefaux-

Vekemans, Pascal Bonnarme, Pierre Briozzo, David Kopecn?, Francesca Pierig?, Mauro Magnani, Rosella Mollicone,

Farhad Haghighi-Rad, Yann Gaston-Math?, Julien Dairou, Claude Boucheix, and Rapha?l Saffroy

S Combining Multiscale Experimental and Computational Systems Pharmacological Approaches to Overcome Resistance to

531

HER2-targeted Therapy in Breast Cancer

Tanaya R. Vaidya, Anusha Ande, and Sihem Ait-Oudhia

DRUG DISCOVERY AND TRANSLATIONAL MEDICINE

Effects of Tegoprazan, a Novel Potassium-Competitive Acid Blocker, on Rat Models of Gastric Acid?Related Disease

318

Dong Kyu Kim, Keun-Ho Lee, Sung-jun Kim, Soo-Jin Kim, Song Jin Lee, Chi Hye Park, Bong-Tae Kim, Geun-Seog

Song, Byoung-Seok Moon, and Shin-Young Ryu

S Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily

337

Dosing Regimen for Nemiralisib

M. Begg, R. Wilson, J.N. Hamblin, M. Montembault, J. Green, A. Deans, A. Amour, S. Worsley, K. Fantom, Y. Cui,

G. Dear, S. Ahmad, A. Kielkowska, J. Clark, M. Boyce, A. Cahn, and E.M. Hessel

S Modulation of TARP g8?Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain

345

Kelly L. Knopp, Rosa Maria A. Simmons, Wenhong Guo, Benjamin L. Adams, Kevin M. Gardinier, Douglas L. Gernert,

Paul L. Ornstein, Warren Porter, Jon Reel, Chunjin Ding, He Wang, Yuewei Qian, Kevin D. Burris, Anne Need,

Vanessa Barth, Steven Swanson, John Catlow, Jeffrey M. Witkin, Ruud Zwart, Emanuele Sher, Kar-Chan Choong,

Theron M. Wall, Douglas Schober, Christian C. Felder, Akihiko S. Kato, David S. Bredt, and Eric S. Nisenbaum

Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in

364

Parkinson's Disease

Patrick A. Howson, Tom H. Johnston, Paula Ravenscroft, Michael P. Hill, Jin Su, Jonathan M. Brotchie, and

James B. Koprich

S Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational

406

Pharmacokinetic-Pharmacodynamic Analysis

Harvey Wong, Lichuan Liu, Wenjun Ouyang, Yuzhong Deng, Matthew R. Wright, and Cornelis E.C.A. Hop

Beneficial Metabolic Effects of Mirabegron In Vitro and in High-Fat Diet-Induced Obese Mice

419

Lei Hao, Sheyenne Scott, Mehrnaz Abbasi, Yujiao Zu, Md Shahjalal Hossain Khan, Yang Yang, Dayong Wu, Ling Zhao,

and Shu Wang

Downloaded from jpet. at ASPET Journals on January 5, 2023

S Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation

428

of Safety Outcomes

Francois Pognan, Philippe Couttet, Ivan Demin, Birgit Jaitner, Yinuo Pang, Ronenn Roubenoff, Esther Sutter,

Yoav Timsit, Marie Anne Valentin, Beate Vogel, Gaetane Woerly, Armin Wolf, and Ursula Schramm

AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A2: In Vivo Efficacy for Inflammation,

511

Neuropathic Pain, and Pulmonary Fibrosis

Hirotomo Shimizu, Akitoshi Ito, Katsuhiko Sakurada, Junji Nakamura, Kosuke Tanaka, Masakazu Komatsu,

Mineko Takeda, Kenichi Saito, Yukiko Endo, Tomohito Kozaki, Motoshi Shoda, and Hiroshi Kuriyama

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

The Selective Sphingosine 1-Phosphate Receptor Modulator Etrasimod Regulates Lymphocyte Trafficking and Alleviates

311

Experimental Colitis

Hussien Al-Shamma, Karin Lehmann-Bruinsma, Chris Carroll, Michelle Solomon, H. Kiyomi Komori,

Laurent Peyrin-Biroulet, and John Adams

Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet

375

Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Takashi Sonobe, Mikiyasu Shirai, and James T. Pearson

Development and Characterization of a Novel, High-Affinity, Specific, Radiolabeled Ligand for BRS-3 Receptors

454

Irene Ramos-Alvarez, Lingaku Lee, Samuel A. Mantey, and Robert T. Jensen

Role of Bitter Taste Receptors in Regulating Gastric Accommodation in Guinea Pigs

466

Yumi Harada, Junichi Koseki, Hitomi Sekine, Naoki Fujitsuka, and Hiroyuki Kobayashi

S CXA-10, a Nitrated Fatty Acid, Is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy

503

Cynthia M. Arbeeny, Hong Ling, Mandy M. Smith, Stephen O'Brien, Stefan Wawersik, Steven R. Ledbetter,

Allen McAlexander, Francisco J. Schopfer, Robert N. Willette, and Diane K. Jorkasky

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

S Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using

443

GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase d Inhibitor

Malcolm Begg, Chris D. Edwards, J. Nicole Hamblin, Eleni Pefani, Robert Wilson, Jane Gilbert, Giovanni Vitulli,

David Mallett, Josie Morrell, Martin I. Hingle, Sorif Uddin, Filzah Ehtesham, Miriam Marotti, Andrew Harrell,

Carla F. Newman, Disala Fernando, Jonathan Clark, Anthony Cahn, and Edith M. Hessel

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

S Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and

389

Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites

Sumit Bansal and Aik Jiang Lau

Apolipoprotein A-I Crosses the Blood-Brain Barrier through Clathrin-Independent and Cholesterol-Mediated Endocytosis

481

Andrew L. Zhou, Suresh K. Swaminathan, Geoffry L. Curran, Joseph F. Poduslo, Val J. Lowe, Ling Li,

and Karunya K. Kandimalla

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine

523

Kidney Cells Involves Ciliary Sensing

Aishwarya Jayagopal, Paul R. Brakeman, Peter Soler, Nicholas Ferrell, William Fissell, Deanna L. Kroetz,

and Shuvo Roy

S Supplemental material is available at jpet..

About the cover: This conceptual model illustrates pleiotropic cytoprotective effects of nitro- fatty acids. See the article by Arbeeny et al., (dx.10.1124/jpet.118.254755)

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