Santangelo, Thomas James
Thomas J. Santangelo
290 Aronoff Building 614-688-7845 (Office)
318 West 12th Avenue 614-688-7416 (Lab)
Ohio State University santangelo.11@osu.edu
Columbus, OH 43210
3168 Menzola Drive 614-499-5901 (home/cellular)
Columbus, OH 43228
Education
2003 Ph.D. Biochemistry, Cornell University,
Cellular & Molecular Biology Ithaca, NY
1996 B.S. Biochemistry State University of New York
at Buffalo
Academic Research Positions and Honors
2010-present Assistant Professor, Department of Microbiology, Columbus, Ohio
2009-2010 Research Scientist with Principle Investigator Status, Department of Microbiology, Ohio State University, Columbus, Ohio
2008-2009 Research Associate II, Department of Microbiology, Ohio
State University, Columbus, OH
2008. NIH Postdoctoral Fellow, Department of Microbiology, Ohio
State University, Columbus, OH
2004-2005 University Postdoctoral Fellow, Department of Microbiology,
Ohio State University, Columbus, OH
2003-2004 Postdoctoral Associate, Department of Molecular Biology and
Genetics, Cornell University, Ithaca, NY
1996-2002 Graduate Research Assistant, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY
1998 Graduate Student Teaching Assistant Award
1997-2000 Graduate Teaching Assistant
1996-2000 NIH Training Grant Appointment, Department of Molecular
Biology and Genetics, Cornell University, Ithaca, NY
1993-1996 Undergraduate Research with Dr. Todd Hennessey, Department of Biology, State University of New York at Buffalo, Buffalo, NY
Independent Funding sources
2005-2008 NIH Postdoctoral Fellowship GM073336-01
2004-2005 Ohio State University Postdoctoral Fellowship
Teaching Positions
2006-present Human Biology, Ohio State University, BIO102
Summer and Winter Quarters
Introductory human biology, organ function, human evolution.
Other Professional Activities
2006-present Ad Hoc review for NSF MCB-Biomolecular Systems proposals
2005-present Periodic review of manuscripts submitted to Journal of
Bacteriology, Applied and Environmental Microbiology,
Proceedings of the National Academy of Sciences, Journal of
Molecular Biology, Molecular Cell, Molecular Microbiology,
Nucleic Acids Research, & RNA.
Publications
Research Papers
20- Li, Z.*, T.J. Santangelo*, Cubonova, L., J.N. Reeve and Z. Kelman. 2010.
Affinity Purification of an Archaeal DNA Replication Protein Network. mBio 1:e00221-10. *Co-first authors
19- Santangelo, T.J. and J.N. Reeve. 2010. Deletion of Swith 3 results in an archaeal RNA polymerase that is defective in transcript elongation. J Biol Chem 285:23908-15.
18- Santangelo, T.J., L. Cubonova, and J.N. Reeve. 2010. Thermococcus kadakarensis genetics: TK1827-encoded beta-glycosidase, new positive-selection protocol, and targeted and repetitive deletion technology. Appl Environ Microbiol 76:1044-52
17- Santangelo, T.J., L. Cubonova, L., K.M. Skinner, and J.N. Reeve. 2009. Archaeal intrinsic termination in vivo. J Bacteriol 191:7102-8
16- Dev, K., T. J. Santangelo, S. Rothenburg, D. Neculai, M. Dey, F. Sicheri, T.E. Dever, J.N. Reeve, and A.G. Hinnebusch. 2009. Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Bio 392:701-22.
15- Hirata, A., T. Kanai, T. J. Santangelo, M. Tajiri, K. Manabe, J. N. Reeve, T. Imanaka, and K. S. Murakami. 2008. Archaeal RNA polymerase subunits E and F are not required for transcription in vitro, but a Thermococcus kodakarensis mutant lacking subunit F is temperature-sensitive. Mol Microbiol. 70:623-33.
14- Santangelo, T. J., L. Cubonova, and J. N. Reeve. 2008. Shuttle vector expression in Thermococcus kodakaraensis: contributions of cis elements to protein synthesis in a hyperthermophilic archaeon. Appl Environ Microbiol 74:3099-104.
13- Santangelo, T. J., L. Cubonova, R. Matsumi, H. Atomi, T. Imanaka, and J. N. Reeve. 2008. Polarity in archaeal operon transcription in Thermococcus kodakaraensis. J Bacteriol 190:2244-8.
12- Davydova, E. K., T. J. Santangelo, and L. B. Rothman-Denes. 2007. Bacteriophage N4 virion RNA polymerase interaction with its promoter DNA hairpin. Proc Natl Acad Sci U S A 104:7033-8.
11- Santangelo, T. J., L. Cubonova, C. L. James, and J. N. Reeve. 2007. TFB1 or TFB2 is sufficient for Thermococcus kodakaraensis viability and for basal transcription in vitro. J Mol Biol 367:344-57.
10- French, S. L., T. J. Santangelo, A. L. Beyer, and J. N. Reeve. 2007. Transcription and translation are coupled in Archaea. Mol Biol Evol 24:893-5.
9- Shin, J. H., T. J. Santangelo, Y. Xie, J. N. Reeve, and Z. Kelman. 2007. Archaeal minichromosome maintenance (MCM) helicase can unwind DNA bound by archaeal histones and transcription factors. J Biol Chem 282:4908-15.
8- Holmes, S. F., T. J. Santangelo, C. K. Cunningham, J. W. Roberts, and D. A. Erie. 2006. Kinetic investigation of Escherichia coli RNA polymerase mutants that influence nucleotide discrimination and transcription fidelity. J Biol Chem 281:18677-83.
7- Santangelo, T. J., and J. N. Reeve. 2006. Archaeal RNA polymerase is sensitive to intrinsic termination directed by transcribed and remote sequences. J Mol Biol 355:196-210.
6- Wickstrum, J. R.*, T. J. Santangelo*, and S. M. Egan. 2005. Cyclic AMP receptor protein and RhaR synergistically activate transcription from the L-rhamnose-responsive rhaSR promoter in Escherichia coli. J Bacteriol 187:6708-18. * - Co-first authors
5- Shundrovsky, A., T. J. Santangelo, J. W. Roberts, and M. D. Wang. 2004. A single-molecule technique to study sequence-dependent transcription pausing. Biophys J 87:3945-53.
4- Santangelo, T. J., and J. W. Roberts. 2004. Forward translocation is the natural pathway of RNA release at an intrinsic terminator. Mol Cell 14:117-26.
3- Santangelo, T. J., and J. W. Roberts. 2003. Formation of long DNA templates containing site-specific alkane-disulfide DNA interstrand cross-links for use in transcription reactions. Methods Enzymol 371:120-32.
2- Santangelo, T. J., R. A. Mooney, R. Landick, and J. W. Roberts. 2003. RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins. Genes Dev 17:1281-92.
1- Adelman, K., A. La Porta, T. J. Santangelo, J. T. Lis, J. W. Roberts, and M. D. Wang. 2002. Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior. Proc Natl Acad Sci U S A 99:13538-43.
Book Chapters
3- Santangelo, T.J. and J.N. Reeve. (2010) Genetic Tools and Manipulations of the Hyperthermophilic Heterotrophic Archaeon Thermococcus kodakarensis. In: Koki Horikoshi (ed.), Extremophiles Handbook, DOI 10.1007/978-4-431-53898-1_4.8, Springer Japan KK.
2- Shundrovsky, A., L. Bai, T.J. Santangelo, and M.D. Wang. (2008) Single Molecule Studies of RNA Polymerase Transcription. In A. Bock, R. Curtiss III, J.B. Kaper, F.C. Neidhardt, T. Nystrom, K.E. Rudd, and C.L. Squires (ed.), EcoSal - Escherichia coli and Salmonella: cellular and molecular Biology. [Online.] . ASM Press, Washington, D.C.
1- Santangelo T.J. and J.W. Roberts, Transcription Termination. In: William J. Lennarz and M. Daniel Lane, Editor(s)-in-Chief, Encyclopedia of Biological Chemistry, Elsevier, New York, 2004, Pages 195-199.
Reviews
2- Bai, L., Santangelo, T.J., Wang, M.D. 2006 Single-Molecule Analysis of RNA Polymerase Transcription. Annual Review of Biophysics and Biomolecular Structure. Feb 17.
1- Santangelo, T.J., and Roberts, J.W. 2002. RfaH, a bacterial transcription antiterminator. Mol Cell 9: 698-700.
Published Abstracts for Research Presentations and Posters
2010 Wellcome Trust – 69th Harden Conference. RNAP 2010 – Structure, Function,
and Evolution of RNA Polymerases, Hinxton, U.K.
Post-Initiation Activities of RNA Polymerases, Mountain Lake Lodge, VA
2009 Gordon Research Conference – Archaea, NH, USA
Extremophiles, Beijign, PRC
2007 FASEB Prokaryotic Transcription Initiation, Saxtons River, VT
Gordon Research Conference – Archaea, Proctor, NH
2006 Odd-Pols Transcription Conference, San Francisco, CA
Inter. Symposium on Extremophiles and Their Applications, Yokosuka, Japan
2005 FASEB Prokaryotic Transcription Initiation, Saxtons River, VT
Gordon Research Conference – Archaea, Oxford, England
2004 Post-Initiation Activities of RNA Polymerases, Mountain Lake Lodge, VA
2003 FASEB Prokaryotic Transcription Initiation, Saxtons River, VT
Molecular Genetics of Bacteria and Phage, Madison, WI
2002 FASEB Nucleic Acid Enzymes: Structures, Mechanisms and Novel Applications, Saxtons River, VT
Post-Initiation Activities of RNA Polymerases, Mountain Lake Lodge, VA
Molecular Genetics of Bacteria and Phage, Cold Spring Harbor, NY
2001 FASEB Prokaryotic Transcription Initiation, Saxtons River, VT
Molecular Genetics of Bacteria and Phage, Madison, WI
2000 Post-Initiation Activities of RNA Polymerases, Mountain Lake Lodge, VA
Molecular Genetics of Bacteria and Phage, Cold Spring Harbor, NY
1999 Molecular Genetics of Bacteria and Phage, Madison, WI
Invited Seminars:
2006 Center for Advanced Research in Biotechnology, Molecular Biology Seminar,
“Archaeal Transcription Termination”
2005 Pennsylvania State University, Biochemistry Seminar, “Archaeal Transcription
Termination”
Committees
2010 Microbiology Faculty Search – Bioenergy
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