Ophthalmic Formulary - Moorfields Eye Hospital

[Pages:43]Moorfields Eye Hospital Ophthalmic Formulary

July 2018 (Version 1.24)

Medicines Information Publication

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Ophthalmic Formulary

NICE

As part of the good practice guidance released by NICE (December 2012), every NHS organisation was expected to develop and update a local formulary, which would be made available on the internet from the 1st April.

The aim of the formulary was to: Reflect local needs Reduce variation in prescribing Allow rapid uptake of innovative medicines and treatments (i.e. NICE recommendations)

Features:

1. Accessibility - Everything should be easily accessible from this document. You'll find relevant web links and internal documents (available only to Moorfields Eye Hospital) 2. Contents page - Simply by clicking the drug category, you'll be taken directly to the relevant section. Above and below each page are links, which direct you to the contents page. 3. If a Summary of Product Characteristic or Patient Information Leaflet is available, a link can be found besides each drug/class. We've now also incorporated fact sheets for some of PMU unlicensed products. 4. Relevant resources ? e.g. MEH anti-infective guidelines can be found at the end of each drug category.

Quick Links (Click on tab)

Contents Page

Instructions

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Contents

(Click on drug category to continue)

Infection

Antiamoebic Antibacterial

Antifungal Antiviral Tapeworm

Anti-inflammatory & Adjuncts

Corticosteroids NSAIDs

Immunosuppresants Miscellaneous Antihistamines

Cytotoxic

Ocular Lubricants & Other Eye Drop Preparations

Ocular Lubricants Other (eye drop) preparations

Glaucoma Neovascularisation

Mydriatic & Vasoconstrictor

Mydriatic Vasoconstrictor

Neurological

Botulinum Systemic

Diagnostic &

Surgical

Dye Antiseptic Irrigation General Anaesthesia &

Gases Local Anaesthetic

Viscosurgical Surgical (other)

Other (Systemic)

Bisphosphonates Gastro-intestinal

Analgesics Nutrition

Appendix 1. Fact Sheets

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This medicine

is monitored intensively by the

UK safety regulators ? the MHRA and CHM.

Instructions

Press for Contents

Page

Under each sub-heading you'll find a list of relevant sources

Follow the link for SPC & PIL

Trust Formulary Approval

Relevant Sources

P/L ? Product License

Unlicensed Product License

N ? National Guideline L ? Local (MEH) Guideline

Local or National Guidelines Exists

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Infection

Antiamoebic

Antibacterial

Antifungal

Primary Source MEH Anti-infective Guidelines

Secondary Source Adnexal Service Manual Toxoplasmosis ? Out of Hour Policy Toxoplasma Chorioretinitis (TCR) Guidelines for Moorfields Casualty Department Paediatric Orbital Cellulitis Guidelines

Antiviral

Antiamoebic Infection

Drug Name chlorHEXidine digluconate 0.02% eye drops hexamidine 0.1% eye drops

polihexanide 0.02% eye drops

polihexanide 0.06% eye drops proPAMidine 0.1% eye drops

Access P/L Drug Class

Antiamoebic

Antiamoebic

FACT SHEET

SPC PIL

Antiamoebic Antiamoebic Antiamoebic

Formulary Indication

N* L* Comments

Acanthamoeba keratitis; antiseptic in patients with povidone iodine

allergy

Acanthamoeba keratitis

Tapeworm

Source MEH Anti-infective Guidelines; Cornea and External Disease Induction Manual page 51 MEH Anti-infective Guidelines MEH Anti-infective Guidelines, Cornea and External Disease Induction Manual page 51 MEH Anti-infective Guidelines MEH Anti-infective Guidelines; BNF 64 11.3.1

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Antibacterial Infection

Bacterial Endophthalmitis (Novermber 2005) Cornea and External Disease Induction Manual - Bacterial keratitis page 45 Glaucoma service handbook Guidelines for management of endophthalmitis, viral retinitis/acute retinal necrosis, toxoplasma chorioretinitis

Drug Name

Access P/L Drug Class

amikacin 2.5% eye drops azithroMYCin 1.5% single use eye drops cefTAZidime 5% eye drops

SPC PIL

Antibacterial Antibacterial Antibacterial

cefUROxime 5% eye drops

Antibacterial

chlorAMPhenicol 0.5% eye drops

chlorAMPhenicol 0.5% eye drops (preservative-free bottle) chlorAMPhenicol 0.5% single use eye drops

chlorAMPhenicol 1% eye ointment

SPC PIL & FACT SHEET

Antibacterial Antibacterial Antibacterial Antibacterial

CLArithromycin 1% eye drops

Antibacterial

CLArithromycin 2% eye drops

dexamethasone 0.05% with framycetin 0.5% with gramicidin 0.005% eye/ear drops

erythromycin 0.5% eye ointment

Antibacterial Antibacterial Antibacterial

fusidic acid 1% eye drops

SPC PIL Antibacterial

gentamicin 0.3% eye drops

gentamicin 0.3% eye drops (preservativefree)

gentamicin 1.5% FORTE eye drops

gentamicin 1.5% FORTE eye drops (preservative-free)

Antibacterial Antibacterial Antibacterial Antibacterial

levoFLOXacin 0.5% eye drops

Antibacterial

moxifloxacin 0.5% eye drops penicillin 0.3% eye drops

SPC PIL Antibacterial Antibacterial

Formulary Indication

N* L* Comments

Source

Bacterial & Mycobacteria keratitis

x

Ocular Chlamydia infections; blepharitis

July 2012 DTC

Neisseria conjunctivitis; ophthalmia neonatorum; bacterial keratitis

Neisseria conjunctivitis; ophthalmia neonatorum; bacterial keratitis; blebitis; bleb-related endophthalmitis

bacterial conjunctivitis; ophthalmia neonatorum; bacterial endophthalmitis; post-op prophylaxis; post intravitreal prophylaxis; corneal abrasion; dacryocystitis; canaliculitis; suture removal

No longer available

Bacterial Conjunctivitis

Bacterial Blepharitis

Mycobacterial keratitis

Uninfected inflammatory conditions of the anterior segment where development of bacterial infection is possible Chlamydial conjunctivits & trachomatis Infections due to Staphylococcus (usually in pregnant women)

Bacterial keratitis

BNF 11.3.1; MEH Anti-infective Guidelines

Removed April 2017

Bacterial conjunctivitis; bacterial, sterile & mycobacterial keratitis; bleb-related endophthalmitis; blebitis; intraocular & periocular surgery; suture removal; post intravitreal injections; corneal abrasions Bacterial conjunctivitis; bacterial, sterile & mycobacterial keratitis; bleb-related endophthalmitis; blebitis; intraocular & periocular surgery; suture removal; post intravitreal injections; corneal abrasions

Bacterial keratitis

DTC Oct 2007

July 2012 DTC

BNF 11.3.1; MEH Anti-infective Guidelines

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Drug Name

vancomycin 1.4% eye drops

vancomycin 5% eye drops

spECTinomycin 2g injection cefUROxime 1mg in 0.1mL intracameral prefilled syringe (Aprokam) amikacin 0.4mg in 0.1mL intravitreal injection pre-pack vancomycin 2mg in 0.1mL intravitreal injection pre-pack amikacin 500mg in 2mL injection

amoxicillin 250mg injection

amoxicillin 500mg injection

benzylpenicillin 600mg injection

cefTAZidime 1g injection

cefTAZidime 2g injection

cefTRIaxone 1g injection

cefTRIaxone 2g injection

cefUROxime 250mg injection

cefUROxime 750mg injection

ciprofloxacin 100mg in 50mL infusion

CLArithromycin 500mg injection

Access

P/L Drug Class Antibacterial Antibacterial Antibacterial

Antibacterial

Antibacterial

Antibacterial

SPC PIL SPC PIL SPC PIL SPC PIL

SPC PIL

SPC PIL SPC PIL SPC PIL

Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial

CLINdamycin 300mg in 2mL injection erythromycin lactobionate 1g injection flucLOXacillin 250mg injection flucLOXacillin 500mg injection gentamicin 80mg in 2mL injection teicoplanin 200mg injection

SPC PIL SPC PIL

SPC PIL

SPC PIL SPC PIL

Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial Antibacterial

metroniDAZole 500mg in 100mL infusion

chlorhexidine 0.1% with neomycin sulphate 0.5% nasal cream amoxicillin 125mg in 5mL sugar free suspension amoxicillin 250mg capsules

SPC PIL SPC PIL SPC PIL

Antibacterial

Antibacterial Antibacterial Antibacterial

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Formulary Indication Boston K-pro antibiotic prophylaxis Bacterial keratitis Neisseria conjuctivitis Prophylaxis during intraocular and periocular surgery Bacterial endophthalmitis Bacterial endophthalmitis

Necrotising fasciitis Bacterial endophthalmitis

Neisseria conjunctivitis; ophthalmia neonatorum; orbital cellulitis

Prophylaxis prior to complex adnexal procedures Bacterial endophthalmitis; orbital cellulitis; necrotising fasciitis Orbital cellulitis (with ciprofloxacin), necrotizing fasciitis (with ciprofloxacin & benzylpenicillin)

Orbital cellulitis

Patients positive or at high risk of MRSA - prophylaxis in surgery orbital cellulitis (with ceftriaxone & flucloxacillin) MRSA eradication if allergy to mupirocin

N* L* Comments

May 2012 DTC Oct 2011

Source

BNF 5.1; MEH Anti-infective Guidelines

BNF 5.1; MEH Anti-infective Guidelines; Paediatric Orbital Cellulitis

BNF 5.1; MEH Anti-infective Guidelines

BNF 5.1; MEH Anti-infective

Guidelines; Paediatric Orbital

Cellulitis BNF 5.1; MEH Anti-infective Guidelines BNF 5.1; MEH Anti-infective

Guidelines; Paediatric Orbital

Cellulitis BNF 5.1; MEH Anti-infective Guidelines

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