Case 3748 -saude.pt



Case 3748

Cystic tumor of the pancreas

Author(s)

Henrique Rodrigues, Pedro Belo Oliveira, Paulo Donato, Filipe Caseiro-Alves

 

Patient

female, 55 year(s)

Clinical Summary

We describe a case of a 55-year-old female, with epigastric pain and vomiting for the last two months. Abdominal ultrasound and a CT showed the presence of a cystic mass in the pancreatic body and tail, without secondary lesions. After surgery, the pathologist stated that the lesion was a mucinous cystadenoma.

Clinical History and Imaging Procedures

The 55-year-old female was referred to our hospital with complaints of epigastric pain and vomiting with two months of evolution. A physical examination was done, which depicted the presence of an ill-defined non-tender epigastric mass, with fluctuation. The laboratory data showed that there were no significant changes. An ultrasound examination showed that the mass, measuring maximum 15 cm in diameter, arose from pancreatic tail and body and had a liquid nature, with multiple thin internal septations, defining cystic spaces with more than 2 cm (Fig. 1). Better characterization was achieved with abdominal CT that depicted the low attenuation mass, with well-defined borders, thin internal septations that enhance after an intravenous administration of contrast media, without mural nodules, calcifications or apparent secondary lesions (Figs. 2,3). The patient underwent a partial pancreatectomy along with splenectomy, and the pathologist stated that the lesion was a mucinous cystadenoma of the pancreas. The patient remained in clinical and radiological surveillance for two years.

Discussion

Cystic neoplasms of the pancreas account for less than 5% of the pancreatic tumors and 10% of the pancreatic cystic lesions [1]. Mucinous tumors mainly affect females between the age group of 40 and 60 years. They are usually localized in the body and the tail of the pancreas and are formed by less than six cysts with more than 2 cm. They have peripheral calcifications in 20% of the cases and show enhancement in the septa after an intravenous administration of contrast media [2]. Histopathologically, these tumors are divided into benign (mucinous cystadenoma), borderline and malignant (mucinous cystadenocarcinoma). On sonograms, mucinous cystadenoma appears as a well-defined predominantly cystic mass, with internal septations and occasionally peripheral calcifications. Mural nodules and solid components may be seen, particularly in malignant forms (mucinous cystadenocarcinoma) [3]. The abdominal CT done with an intravenous administration of contrast media depicts the characteristics reported previously, but can have significant interest in differential diagnosis with cystadenocarcinoma (malignant form), by excluding the presence of thick septations, mural nodules, hepatic lesions and peritoneal carcinomatosis [4]. On gadolinium-enhanced T1-weighted fat-suppressed images, large, irregular cystic spaces separated by thick septa are demonstrated [5]. Mucin produced by these tumors may result in high signal intensity on T1- and T2-weighted images of the primary tumor and liver metastases. Liver metastases are generally hypervascular and have an intense enhancement on immediate post-gadolinium images [6]. Mucinous cystadenomas show no evidence of metastases or invasion of adjacent tissues. The mucinous cystadenocarcinoma may be very locally aggressive with an extensive invasion of the adjacent tissues; however, the absence of the demonstration of tumor invasion does not exclude the malignancy [6]. The aspiration of the cystic fluid with cytological analysis and the determination of viscosity, amylase, CEA, Ca 72-4, Ca-125, and Ca 15-3 can be of great value in the characterization of cystic lesions in the pancreas [7]. Those parameters can help in distinction between pseudocysts versus neoplasms and between different kinds of cystic neoplasms. The level of amylase is high only in pseudocysts, and all the other markers are low. Ca15-3 value of 30 U/ml was 100% sensitive and specific in differentiating histological benign and malignant mucinous neoplasms [8]. In a study, Hammel [9] showed 98 % specificity for a CA 72-4 level greater than 40 U/ml in distinguishing mucinous neoplasm from pseudocysts and serous cystadenomas. Viscosity is only elevated in pseodocyst’s and serous cystadenomas. Cytolology may be helpful when depicts epithelial cells, because pseudocyst’s wall don’t have a epithelial lining. The available evidence seems to indicate that mucinous cystic neoplasm’s are potentially, and perhaps inevitably, malignant tumors, so surgical excision is recommended.

Final Diagnosis

Mucinous cystadenoma of the pancreas.

 

MeSH

1. Pancreas [A03.734]

A mixed exocrine and endocrine gland situated transversely across the posterior abdominal wall in the epigastric and hypochondriac regions. The endocrine portion is comprised of the ISLETS OF LANGERHANS, while the exocrine portion is a compound acinar gland that secretes digestive enzymes.

2. Pancreatic Cyst [C06.689.500]

A true cyst of the pancreas to be distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a mucous epithelial lining. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of pancreatic ducts secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)

References

1. [1]

1.Weissleder R, Wittenberg J, Harisinghani M. Primer of Diagnostic Imaging, third edition:. Mosby, 2003; 234-244

2. [2]

2.Murfitt J. The Pancreas. Sutton D. Textbook of Radiology and Imaging, seventh edition. Churchill Livingstone, 2003; 787-824

3. [3]

3.Middleton W, Kurtz A, Hertzberg. The Requisits: Ultrasound. Mosby, 2004; 191-207.

4. [4]

4.Prokop C. The pancreas. Prokop M, Galanski M. Spiral and Multislice Computed Tomography of the Body. Thieme, 2003; 522-523

5. [5]

5.Semelka RC, Ascher SM: MRI of the pancreas- state of the art. Radiology 1993, 188. 593-602

6. [6]

6.Semelka RC, Nagase LL, Armao D, Balci C. Pancreas. Semelka RC. Abdominal-Pelvic MRI. Wiley-Liss 2002; 440

7. [7]

7.Hammel P, etal. Preoperative cyst fluid analysis useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology 1995, 108: 1230-1235

8. [8]

8.Rubin D: Expression of CA 15-3 protein in the cyst contents distinguishes benign from malignant pancreatic mucinous cystic neoplasm. Surgery 1994, 115:52-55

9. [9]

9.Hammel P: Diagnostic value of cyst fluid analysis in cystic lesions of the pancreas: Current data, limitations and perspectives. J Radiology 2000; 81(5): 487-90

Citation

Henrique Rodrigues, Pedro Belo Oliveira, Paulo Donato, Filipe Caseiro-Alves (2006, Jul 27).

Cystic tumor of the pancreas, {Online}.

URL:

DOI: 10.1594/EURORAD/CASE.3748

• Figure 1

Abdominal ultrasound

[pic]

An epigastric abdominal ultrasound showing a liquid mass with internal septa, measuring 15 cm, dependent on the pancreatic body and tail.

• Figure 2

Abdominal CT

[pic]

An abdominal CT image taken after an intravenous administration of the contrast medium, depicting the multilocular mass (cysts bigger than 2 cm), an enhancement of septa and the absence of mural nodules and calcifications.

• Figure 3

Abdominal CT

[pic]

An abdominal CT image taken after an intravenous administration of the contrast medium, depicting the multicystic nature of the mass (cysts bigger than 2 cm), an enhancement of septa and absence of mural nodules or calcifications.

................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download