Supplementary materials for Deane et al, “Omega 3 and ...



Supplementary materials for Deane et al, “Omega 3 and polyunsaturated fat for prevention of depression and anxiety”. Contents TOC \o "1-3" \h \z \u Supplementary materials for Deane et al, “Omega 3 and polyunsaturated fat for prevention of depression and anxiety”. PAGEREF _Toc22138764 \h 1Supplementary Text 1. Results section in greater detail PAGEREF _Toc22138765 \h 3Characteristics of included studies PAGEREF _Toc22138766 \h 3Does increasing omega-3, omega-6 or total PUFA alter risk of depression or anxiety? PAGEREF _Toc22138767 \h 3Supplementary Table 1. Brief characteristics of included studies PAGEREF _Toc22138768 \h 7Supplementary Table 2. High vs low long-chain omega 3 (primary outcomes) PAGEREF _Toc22138769 \h 11Supplementary Table 3: GRADE assessment: Summary of findings for effects of long-chain omega-3 (LCn3) on depression and anxiety PAGEREF _Toc22138770 \h 15Supplementary Table 4. High vs low ALA (primary outcomes) PAGEREF _Toc22138771 \h 18Supplementary Table 5. High vs low total PUFA (primary outcomes) PAGEREF _Toc22138772 \h 19Supplementary Table 6: GRADE assessment: Summary of findings for effects of total PUFA on depression and anxiety PAGEREF _Toc22138773 \h 20Supplementary Table 7: GRADE assessment: Summary of findings for effects of ALA on depression and anxiety PAGEREF _Toc22138774 \h 22Supplementary Table 8. High vs low long-chain omega 3 (secondary outcomes) PAGEREF _Toc22138775 \h 24Supplementary Table 9. High vs low ALA (secondary outcomes) PAGEREF _Toc22138776 \h 25Supplementary Table 10. Characteristics of ongoing trials that appear to have assessed relevant outcomes for this review PAGEREF _Toc22138777 \h 26Supplementary Figure 1. Study flow diagram. PAGEREF _Toc22138778 \h 32Supplementary Figure 2. Meta-analysis of effects of higher LCn3 vs lower LCn3 on risk of depression symptoms, sub-grouped by LCn3 dose. PAGEREF _Toc22138779 \h 33Supplementary Figure 3. Meta-analysis of effects of higher LCn3 vs lower LCn3 on risk of depression symptoms, sub-grouped by EPA dose. PAGEREF _Toc22138780 \h 34Supplementary Figure 4. Meta-analysis of effects of higher LCn3 vs lower LCn3 on risk of depression symptoms, sub-grouped by DHA dose. PAGEREF _Toc22138781 \h 35Supplementary Figure 5. Funnel plot of the analysis of effects of higher LCn3 vs lower LCn3 on risk of depression. PAGEREF _Toc22138782 \h 36Supplementary Figure 6. Meta-analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, analysed using SMD, sub-grouped by LCn3 dose. PAGEREF _Toc22138783 \h 37Supplementary Figure 7. Meta-analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, analysed using SMD, sub-grouped by EPA dose. PAGEREF _Toc22138784 \h 38Supplementary Figure 8. Meta-analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, analysed using SMD, sub-grouped by DHA dose. PAGEREF _Toc22138785 \h 39Supplementary Figure 9. Funnel plot of the analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, using SMD, sub-grouped by depression rating scale. PAGEREF _Toc22138786 \h 40Supplementary Figure 10. Forest plot of trials randomising to higher vs lower LCn3 intake and assessing depression symptoms (on a continuous scale) in those without depression at baseline, subgrouping by scale and displayed in native scales. For meta-analysis data were combined using SMD (not shown, SMD 0.01, 95% CI -0.06 to 0.07, I2 46%). PAGEREF _Toc22138787 \h 41Acknowledgements: PAGEREF _Toc22138788 \h 42Supplementary References PAGEREF _Toc22138789 \h 43Supplementary Text 1. Results section in greater detailCharacteristics of included studiesCharacteristics of included studies and risk of bias are shown in Supplementary Table 1 and in more detail in our database paper ADDIN EN.CITE <EndNote><Cite><Author>Hooper</Author><Year>2019</Year><RecNum>21697</RecNum><DisplayText>(1)</DisplayText><record><rec-number>21697</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1541241884">21697</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hooper, Lee</author><author>Abdelhamid, Asmaa</author><author>Brainard, Julii</author><author>Deane, Katherine H. O.</author><author>Song, Fujian</author></authors></contributors><titles><title>Creation of a database to assess effects of omega-3, omega-6 and total polyunsaturated fats on health: database and methodology for a set of reviews</title><secondary-title>BMJ Open </secondary-title></titles><periodical><full-title>BMJ Open</full-title><abbr-1>BMJ Open</abbr-1></periodical><pages>e029554</pages><volume>9</volume><number>5</number><dates><year>2019</year></dates><urls><related-urls><url>: 10.1136/bmjopen-2019-029554</electronic-resource-num></record></Cite></EndNote>(1), risk of bias is itemised by domain for each study in Figure 1, flow diagram for this review in Supplementary Figure 1. The 32 RCTs (33 comparisons) randomised 46,467 participants, of which twelve were judged to be at low summary risk of bias PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLTE0KTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxh

dXRob3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwg

R3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3Jv

bWhvdXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZl

cnNpdHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zh

c2N1bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxl

PjxhbHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48

YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+

VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+

PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNp

bmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08

L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJy

LTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwv

dm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9y

ZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBD

YXJkaW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIg

RGlzZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50

cyBEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVu

b2ljIEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBU

aGVyYXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRl

cz48aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDU2L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVk

IFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBw

b3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48

dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1w

O05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6

Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIw

OTI5MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00

NzkzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUm

YW1wO3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91

cm5hbCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFz

Y3VsYXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9t

aG91dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjI4MzA8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+Q2hldywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+

PGF1dGhvcj5BZ3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48

YXV0aG9yPkdyb2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1

dGhvcj48YXV0aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24g

b2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFs

cyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBI

ZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29y

cG9yYXRpb24sIFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2Yg

RXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBC

cmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9n

eSBTZWN0aW9uLCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRl

cyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBh

cnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhh

cnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9m

IEVwaWRlbWlvbG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBN

YXNzYWNodXNldHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJz

aXR5IG9mIFV0YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

RWZmZWN0IG9mIE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhl

ciBOdXRyaWVudCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJF

RFMyIFJhbmRvbWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFN

QTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGlj

YWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVy

aWNhbiBNZWRpY2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1

bWU+PG51bWJlcj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmlu

dC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3Jp

dGhtcyBBc2NvcmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2du

aXRpb24gQ29udGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJh

dGlvbiAmYW1wOyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMg

QWNpZHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhv

ZCAqRWljb3NhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9k

YXRlcz48aXNibj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8x

MC4xMDAxL2phbWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJv

bGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2Vi

LmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1l

ZGwmYW1wO0FOPTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklE

Om1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4y

MDE1Ljk2NzcmYW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7

aXNzdWU9OCZhbXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1w

O3RpdGxlPUpBTUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytM

dXRlaW4lMkZaZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitv

bitDb2duaXRpdmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1Ry

aWFsLiZhbXA7YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+

PC9DaXRlPjxDaXRlPjxBdXRob3I+QVNDRU5EIFN0dWR5IENvbGxhYm9yYXRpdmUgR3JvdXA8L0F1

dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNOdW0+MjE3MDE8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjIxNzAxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NDIx

NDA2MjkiPjIxNzAxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BU0NF

TkQgU3R1ZHkgQ29sbGFib3JhdGl2ZSBHcm91cCw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PHRpdGxlcz48dGl0bGU+RWZmZWN0cyBvZiBu4oiSMyBGYXR0eSBBY2lkIFN1cHBsZW1l

bnRzIGluIERpYWJldGVzIE1lbGxpdHVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldyBFbmds

YW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9mdWxsLXRp

dGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpNPC9hYmJyLTI+PGFi

YnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJici0zPjwvcGVyaW9k

aWNhbD48cGFnZXM+MTU0MC0xNTUwPC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1lPjxudW1iZXI+

MTY8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMTgv

MTAvMTg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPk1hc3NhY2h1c2V0dHMg

TWVkaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAyOC00NzkzPC9pc2JuPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwczovL2RvaS5vcmcvMTAuMTA1Ni9ORUpNb2ExODA0OTg5PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU2

L05FSk1vYTE4MDQ5ODk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3MtZGF0ZT4yMDE4

LzExLzEzPC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EZXJvc2E8

L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+MTgzODI8L1JlY051bT48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE4MzgyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAzMDQxMzUiPjE4MzgyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5E

ZXJvc2EsIEcuPC9hdXRob3I+PGF1dGhvcj5DaWNlcm8sIEEuIEYuPC9hdXRob3I+PGF1dGhvcj5E

JmFwb3M7QW5nZWxvLCBBLjwvYXV0aG9yPjxhdXRob3I+Qm9yZ2hpLCBDLjwvYXV0aG9yPjxhdXRo

b3I+TWFmZmlvbGksIFAuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+

PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIFBVRkFzIG9uIGZhc3RpbmcgcGxhc21hIGdsdWNvc2UgYW5k

IGluc3VsaW4gcmVzaXN0YW5jZSBpbiBwYXRpZW50cyB3aXRoIGltcGFpcmVkIGZhc3RpbmcgZ2x1

Y29zZSBvciBpbXBhaXJlZCBnbHVjb3NlIHRvbGVyYW5jZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5CaW9GYWN0b3JzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+QmlvRmFjdG9ycyAoT3hmb3JkLCBFbmdsYW5kKTwvZnVsbC10aXRsZT48YWJici0xPkJp

b0ZhY3RvcnM8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjMxNi0zMjI8L3BhZ2VzPjx2b2x1

bWU+NDI8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48

L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EYW50aGlp

cjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xODMxNDwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTgzMTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDMwNDA5NyI+MTgzMTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkRhbnRoaWlyLCBWLjwvYXV0aG9yPjxhdXRob3I+SG9za2luZywgRC48L2F1dGhvcj48YXV0aG9y

PkJ1cm5zLCBOLiBSLjwvYXV0aG9yPjxhdXRob3I+V2lsc29uLCBDLjwvYXV0aG9yPjxhdXRob3I+

TmV0dGVsYmVjaywgVC48L2F1dGhvcj48YXV0aG9yPkNhbHZhcmVzaSwgRS48L2F1dGhvcj48YXV0

aG9yPmV0LCBhIGw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0

bGU+Q29nbml0aXZlIHBlcmZvcm1hbmNlIGluIG9sZGVyIGFkdWx0cyBpcyBpbnZlcnNlbHkgYXNz

b2NpYXRlZCB3aXRoIGZpc2ggY29uc3VtcHRpb24gYnV0IG5vdCBlcnl0aHJvY3l0ZSBtZW1icmFu

ZSBuLTMgZmF0dHkgYWNpZHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VGhlIEpvdXJuYWwgb2Yg

bnV0cml0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+Sm91cm5hbCBvZiBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KIE51dHI8L2FiYnIt

MT48YWJici0yPlRoZSBqb3VybmFsIG9mIG51dHJpdGlvbjwvYWJici0yPjwvcGVyaW9kaWNhbD48

cGFnZXM+MzExLTMyMDwvcGFnZXM+PHZvbHVtZT4xNDQ8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJl

cj48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5WZWxsYXM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNO

dW0+MTY2MTc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE2NjE3PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0

YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTg3NDIiPjE2NjE3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WZWxsYXMsIEIuPC9hdXRob3I+PGF1dGhvcj5DYXJy

aWUsIEkuPC9hdXRob3I+PGF1dGhvcj5HdXlvbm5ldCwgUy48L2F1dGhvcj48YXV0aG9yPlRvdWNo

b24sIEouPC9hdXRob3I+PGF1dGhvcj5EYW50b2luZSwgVC48L2F1dGhvcj48YXV0aG9yPkRhcnRp

Z3VlcywgSi4gRi48L2F1dGhvcj48YXV0aG9yPkN1ZmksIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5C

b3JkZXMsIFMuPC9hdXRob3I+PGF1dGhvcj5HYXNuaWVyLCBZLjwvYXV0aG9yPjxhdXRob3I+Um9i

ZXJ0LCBQLjwvYXV0aG9yPjxhdXRob3I+Qm9yaWVzLCBMLjwvYXV0aG9yPjxhdXRob3I+Um91YXVk

LCBPLjwvYXV0aG9yPjxhdXRob3I+RGVzY2xhdXgsIEYuPC9hdXRob3I+PGF1dGhvcj5TdWRyZXMs

IEsuPC9hdXRob3I+PGF1dGhvcj5Cb25uZWZveSwgTS48L2F1dGhvcj48YXV0aG9yPlBlc2NlLCBB

LjwvYXV0aG9yPjxhdXRob3I+Rm91Z2VyZSwgQi48L2F1dGhvcj48YXV0aG9yPkRlbHJpZXUsIEou

PC9hdXRob3I+PGF1dGhvcj5GYWlzYW50LCBDLjwvYXV0aG9yPjxhdXRob3I+TGFsYSwgRi48L2F1

dGhvcj48YXV0aG9yPkR1cHV5LCBDLjwvYXV0aG9yPjxhdXRob3I+Q2FudGV0LCBDLjwvYXV0aG9y

PjxhdXRob3I+Q29sZXksIE4uPC9hdXRob3I+PGF1dGhvcj5CZWxsZXZpbGxlLCBTLjwvYXV0aG9y

PjxhdXRob3I+V2lsbGlzLCBTLiBMLjwvYXV0aG9yPjxhdXRob3I+V2VpbmVyLCBNLiBXLjwvYXV0

aG9yPjxhdXRob3I+SmVhbiBPdXNzZXQsIFAuPC9hdXRob3I+PGF1dGhvcj5BbmRyaWV1LCBTLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPihWZWxsYXMpIElO

U0VSTSBVTVIgMTAyNywgVG91bG91c2UsIEZyYW5jZSAoVmVsbGFzLCBHdXlvbm5ldCwgQ29sZXkp

IFVuaXZlcnNpdHkgb2YgVG91bG91c2UgSUlJLCBUb3Vsb3VzZSwgRnJhbmNlIChWZWxsYXMsIExh

bGEsIEplYW4gT3Vzc2V0KSBDSFUgVG91bG91c2UsIFRvdWxvdXNlLCBGcmFuY2UgKENhcnJpZSwg

R3V5b25uZXQsIEZvdWdlcmUsIEZhaXNhbnQsIER1cHV5LCBDYW50ZXQsIEFuZHJpZXUpIFRvdWxv

dXNlRnJhbmNlIChHdXlvbm5ldCwgRHVwdXksIENhbnRldCwgQ29sZXkpIElOU0VSTSBVTVIgMTAy

NywgRnJhbmNlIChUb3VjaG9uKSBDSFUgTW9udHBlbGxpZXIsIE1vbnRwZWxsaWVyLCBGcmFuY2Ug

KERhbnRvaW5lKSBDSFUgTGltb2dlcywgTGltb2dlcywgRnJhbmNlIChEYXJ0aWd1ZXMpIElOU0VS

TSBVODk3LCBCb3JkZWF1eCwgRnJhbmNlIChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHks

IEJvcmRlYXV4LCBGcmFuY2UgKERhcnRpZ3VlcykgTWVtb3J5IGNvbnN1bHRhdGlvbiwgQ0hVIEJv

cmRlYXV4LCBCb3JkZWF1eCwgRnJhbmNlIChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHkg

SG9zcGl0YWwsIEJvcmRlYXV4LCBGcmFuY2UgKEN1ZmkpIENIIENhc3RyZXMsIENhc3RyZXMsIEZy

YW5jZSAoQm9yZGVzLCBHYXNuaWVyKSBDSCBUYXJiZXMsIFRhcmJlcywgRnJhbmNlIChSb2JlcnQp

IENIVSBOaWNlLCBOaWNlLCBGcmFuY2UgKEJvcmllcykgQ0ggRm9peCwgRm9peCwgRnJhbmNlIChS

b3VhdWQpIEhvcGl0YWwgR2VuZXJhbCwgRGlqb24sIEZyYW5jZSAoRGVzY2xhdXgpIENIIExhdmF1

ciwgTGF2YXVyLCBGcmFuY2UgKFN1ZHJlcykgQ0ggTW9udGF1YmFuLCBNb250YXViYW4sIEZyYW5j

ZSAoQm9ubmVmb3kpIENIVSBMeW9uIFNVRCwgTHlvbiwgRnJhbmNlIChQZXNjZSkgQ0ggUHJpbmNl

c3NlIEdyYWNlLCBNb25hY28sIE1vbmFjbyAoRGVscmlldSkgSW5zdGl0dXRlIG9mIEFnaW5nLCBV

bml2ZXJzaXR5IEhvc3BpdGFsIFRvdWxvdXNlLCBUb3Vsb3VzZSwgRnJhbmNlIChCZWxsZXZpbGxl

KSBJbnN0aXR1dCBVbml2ZXJzaXRhaXJlIERlIEdlcmlhdHJpZSBEZSBNb250cmVhbCwgTW9udHJl

YWwsIFFDLCBDYW5hZGEgKEJlbGxldmlsbGUpIFVuaXZlcnNpdGUgRGUgTW9udHJlYWwsIE1vbnRy

ZWFsLCBRQywgQ2FuYWRhIChXaWxsaXMpIEluZGlhbmEgVW5pdmVyc2l0eSwgSW5kaWFuYXBvbGlz

LCBJTiwgVW5pdGVkIFN0YXRlcyAoV2VpbmVyKSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEgU2Fu

IEZyYW5jaXNjbywgU2FuIEZyYW5jaXNjbywgQ0EsIFVuaXRlZCBTdGF0ZXMgKEFuZHJpZXUpIElO

U0VSTSBVTVIgMTAyNywgUGF1bCBTYWJhdGllciBVbml2ZXJzaXR5LCBUb3Vsb3VzZSwgRnJhbmNl

IEIuIFZlbGxhcywgSU5TRVJNIFVNUiAxMDI3LCBUb3Vsb3VzZSwgRnJhbmNlLiBFLW1haWw6IHZl

bGxhcy5iQGNodS10b3Vsb3VzZS5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1BUFQg

KG11bHRpLWRvbWFpbiBBbHpoZWltZXImYXBvcztzIHByZXZlbnRpb24gdHJpYWwpOiBSZXN1bHRz

IGF0IDM2IG1vbnRoczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbHpoZWltZXImYXBvcztzIGFu

ZCBEZW1lbnRpYTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkFsemhlaW1lciZhcG9zO3MgJmFtcDsgRGVtZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5B

bHpoZWltZXImYXBvcztzIGRlbWVudDwvYWJici0xPjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBh

bmQgRGVtZW50aWE8L2FiYnItMj48YWJici0zPkFsemhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJy

LTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMzE8L3BhZ2VzPjx2b2x1bWU+MSk8L3ZvbHVtZT48cmVw

cmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPnByZXZlbnRpb24gc3R1ZHkgaHVtYW4gY29nbml0aW9uIG1lbW9yeSBzYWZldHkgZGlnaXQg

c3ltYm9sIHN1YnN0aXR1dGlvbiB0ZXN0IGNsaW5pY2FsIHRyaWFsIGhvc3BpdGFsIHRyYWlsIG1h

a2luZyB0ZXN0IG51dHJpdGlvbiBwaHlzaWNhbCBhY3Rpdml0eSBvdXRwYXRpZW50IGFnZWQgc3Vw

cGxlbWVudGF0aW9uIGFkdWx0IFdlY2hzbGVyIGFkdWx0IGludGVsbGlnZW5jZSBzY2FsZSBNaW5p

IE1lbnRhbCBTdGF0ZSBFeGFtaW5hdGlvbiBvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxNTwveWVhcj48L2RhdGVzPjxpc2JuPjE1NTItNTI2MDwvaXNibj48d29yay10eXBl

PkNvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX

Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMyZhbXA7QU49NzIxMjQ1NzFodHRwOi8v

c2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtpZD1wbWlkOiZhbXA7

aWQ9ZG9pOiZhbXA7aXNzbj0xNTUyLTUyNjAmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTEmYW1wO2lz

c3VlPTcrU1VQUEwuKzEmYW1wO3NwYWdlPVAzMzEmYW1wO3BhZ2VzPVAzMzEmYW1wO2RhdGU9MjAx

NSZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3cythbmQrRGVtZW50aWEmYW1wO2F0aXRsZT1NQVBUKyUy

OG11bHRpLWRvbWFpbitBbHpoZWltZXIlMjdzK3ByZXZlbnRpb24rdHJpYWwlMjklM0ErUmVzdWx0

cythdCszNittb250aHMmYW1wO2F1bGFzdD1WZWxsYXM8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+WXVya28tTWF1cm88L0F1dGhvcj48WWVh

cj4yMDEwPC9ZZWFyPjxSZWNOdW0+MTc3MjQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE3

NzI0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBh

dzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTk0MTgiPjE3

NzI0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5ZdXJrby1NYXVybywg

Sy48L2F1dGhvcj48YXV0aG9yPk1jQ2FydGh5LCBELjwvYXV0aG9yPjxhdXRob3I+Um9tLCBELjwv

YXV0aG9yPjxhdXRob3I+TmVsc29uLCBFLiBCLjwvYXV0aG9yPjxhdXRob3I+UnlhbiwgQS4gUy48

L2F1dGhvcj48YXV0aG9yPkJsYWNrd2VsbCwgQS48L2F1dGhvcj48YXV0aG9yPlNhbGVtLCBOLiwg

SnIuPC9hdXRob3I+PGF1dGhvcj5TdGVkbWFuLCBNLjwvYXV0aG9yPjxhdXRob3I+SW52ZXN0aWdh

dG9ycywgTWlkYXM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5ZdXJrby1NYXVybyxLYXJpbi4gQ2xpbmljYWwgUmVzZWFyY2ggRGVwYXJ0bWVudCwgTWFydGVr

IEJpb3NjaWVuY2VzIENvcnBvcmF0aW9uLCBDb2x1bWJpYSwgTUQsIFVTQS4ga3l1cmtvQG1hcnRl

ay5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5CZW5lZmljaWFsIGVmZmVjdHMgb2Yg

ZG9jb3NhaGV4YWVub2ljIGFjaWQgb24gY29nbml0aW9uIGluIGFnZS1yZWxhdGVkIGNvZ25pdGl2

ZSBkZWNsaW5lPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFsemhlaW1lciZhcG9zO3MgJmFtcDsg

RGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFsemhlaW1lciZhcG9zO3MgZGVt

ZW50PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QWx6aGVpbWVy

JmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvZnVsbC10aXRsZT48YWJici0xPkFsemhlaW1lciZhcG9z

O3MgZGVtZW50PC9hYmJyLTE+PGFiYnItMj5BbHpoZWltZXImYXBvcztzIGFuZCBEZW1lbnRpYTwv

YWJici0yPjxhYmJyLTM+QWx6aGVpbWVycyBhbmQgRGVtZW50aWE8L2FiYnItMz48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFsemhlaW1lciZhcG9zO3MgJmFtcDsgRGVt

ZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbHpoZWltZXImYXBvcztzIGRlbWVudDwvYWJici0x

PjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L2FiYnItMj48YWJici0zPkFs

emhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NDU2

LTQ2NDwvcGFnZXM+PHZvbHVtZT42PC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PHJlcHJpbnQt

ZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5B

Z2VkICpBZ2luZy9kZSBbRHJ1ZyBFZmZlY3RzXSAqQWdpbmcvcHggW1BzeWNob2xvZ3ldICpDb2du

aXRpb24gRGlzb3JkZXJzL2RpIFtEaWFnbm9zaXNdIENvZ25pdGlvbiBEaXNvcmRlcnMvbWUgW01l

dGFib2xpc21dICpDb2duaXRpb24gRGlzb3JkZXJzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRy

b2xdIERlbWVudGlhL2RpIFtEaWFnbm9zaXNdIERlbWVudGlhL2R0IFtEcnVnIFRoZXJhcHldIERl

bWVudGlhL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE1NTItNTI3OTwvaXNibj48d29yay10

eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qYWx6LjIwMTAuMDEuMDEzO1JhbmRvbWl6

ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWRjJmFtcDtBTj0yMDQzNDk2MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2Nh

bD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDM0OTYxJmFtcDtpZD1kb2k6MTAuMTAx

NiUyRmouamFsei4yMDEwLjAxLjAxMyZhbXA7aXNzbj0xNTUyLTUyNjAmYW1wO2lzYm49JmFtcDt2

b2x1bWU9NiZhbXA7aXNzdWU9NiZhbXA7c3BhZ2U9NDU2JmFtcDtwYWdlcz00NTYtNjQmYW1wO2Rh

dGU9MjAxMCZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3cyslMjYrRGVtZW50aWEmYW1wO2F0aXRsZT1C

ZW5lZmljaWFsK2VmZmVjdHMrb2YrZG9jb3NhaGV4YWVub2ljK2FjaWQrb24rY29nbml0aW9uK2lu

K2FnZS1yZWxhdGVkK2NvZ25pdGl2ZStkZWNsaW5lLiZhbXA7YXVsYXN0PVl1cmtvLU1hdXJvPC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlBh

d2VsY3p5azwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4xMjQyMDwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTI0MjA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxNjM0MSI+MTI0MjA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPlBhd2VsY3p5aywgVC48L2F1dGhvcj48YXV0aG9yPkdyYW5jb3ctR3JhYmthLCBNLjwv

YXV0aG9yPjxhdXRob3I+S290bGlja2EtQW50Y3phaywgTS48L2F1dGhvcj48YXV0aG9yPlRyYWZh

bHNrYSwgRS48L2F1dGhvcj48YXV0aG9yPlBhd2VsY3p5aywgQS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5QYXdlbGN6eWssVG9tYXN6LiBEZXBhcnRtZW50

IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywgTWVkaWNhbCBVbml2ZXJzaXR5

IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0yMTYgTG9keiwgUG9sYW5kLiBF

bGVjdHJvbmljIGFkZHJlc3M6IHRvbWFzei5wYXdlbGN6eWtAdW1lZC5sb2R6LnBsLiBHcmFuY293

LUdyYWJrYSxNYXJ0YS4gQ2VudHJhbCBUZWFjaGluZyBIb3NwaXRhbCwgTWVkaWNhbCBVbml2ZXJz

aXR5IG9mIExvZHosIHVsLiBQb21vcnNrYSAyNTEsIDkyLTIxMyBMb2R6LCBQb2xhbmQuIEVsZWN0

cm9uaWMgYWRkcmVzczogbWFydGFncmFuY293QGdtYWlsLmNvbS4gS290bGlja2EtQW50Y3phayxN

YWdkYWxlbmEuIERlcGFydG1lbnQgb2YgQWZmZWN0aXZlIGFuZCBQc3ljaG90aWMgRGlzb3JkZXJz

LCBNZWRpY2FsIFVuaXZlcnNpdHkgb2YgTG9keiwgdWwuIEN6ZWNob3Nsb3dhY2thIDgvMTAsIDky

LTIxNiBMb2R6LCBQb2xhbmQuIEVsZWN0cm9uaWMgYWRkcmVzczogbWFnZGFsZW5hLmtvdGxpY2th

LWFudGN6YWtAdW1lZC5sb2R6LnBsLiBUcmFmYWxza2EsRWx6YmlldGEuIERlcGFydG1lbnQgb2Yg

TnV0cml0aW9uIEh5Z2llbmUgYW5kIEVwaWRlbWlvbG9neSwgTWVkaWNhbCBVbml2ZXJzaXR5IG9m

IExvZHosIHVsLiBKYXJhY3phIDYzLCA5MC0yNTEgTG9keiwgUG9sYW5kLiBFbGVjdHJvbmljIGFk

ZHJlc3M6IGVsemJpZXRhLnRyYWZhbHNrYUB1bWVkLmxvZHoucGwuIFBhd2VsY3p5ayxBZ25pZXN6

a2EuIERlcGFydG1lbnQgb2YgQWZmZWN0aXZlIGFuZCBQc3ljaG90aWMgRGlzb3JkZXJzLCBNZWRp

Y2FsIFVuaXZlcnNpdHkgb2YgTG9keiwgdWwuIEN6ZWNob3Nsb3dhY2thIDgvMTAsIDkyLTIxNiBM

b2R6LCBQb2xhbmQuIEVsZWN0cm9uaWMgYWRkcmVzczogYWduaWVzemthLnBhd2VsY3p5a0B1bWVk

LmxvZHoucGw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BIHJhbmRvbWl6ZWQgY29udHJv

bGxlZCBzdHVkeSBvZiB0aGUgZWZmaWNhY3kgb2Ygc2l4LW1vbnRoIHN1cHBsZW1lbnRhdGlvbiB3

aXRoIGNvbmNlbnRyYXRlZCBmaXNoIG9pbCByaWNoIGluIG9tZWdhLTMgcG9seXVuc2F0dXJhdGVk

IGZhdHR5IGFjaWRzIGluIGZpcnN0IGVwaXNvZGUgc2NoaXpvcGhyZW5pYTwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Kb3VybmFsIG9mIFBzeWNoaWF0cmljIFJlc2VhcmNoPC9zZWNvbmRhcnktdGl0

bGU+PGFsdC10aXRsZT5KIFBzeWNoaWF0ciBSZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNoaWF0cmljIFJlc2VhcmNoPC9mdWxsLXRp

dGxlPjxhYmJyLTE+SiBQc3ljaGlhdHIgUmVzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNoaWF0cmljIFJlc2VhcmNoPC9mdWxs

LXRpdGxlPjxhYmJyLTE+SiBQc3ljaGlhdHIgUmVzPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48

cGFnZXM+MzQtNDQ8L3BhZ2VzPjx2b2x1bWU+NzM8L3ZvbHVtZT48cmVwcmludC1lZGl0aW9uPk5P

VCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PC9kYXRl

cz48aXNibj4xODc5LTEzNzk8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDE2L2ouanBzeWNoaXJlcy4yMDE1LjExLjAxMztSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH

b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1wcmVtJmFtcDtBTj0yNjY3OTc2M2h0dHA6Ly9zZngudWNsLmFjLnVr

L3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjI2Njc5NzYzJmFtcDtpZD1k

b2k6MTAuMTAxNiUyRmouanBzeWNoaXJlcy4yMDE1LjExLjAxMyZhbXA7aXNzbj0wMDIyLTM5NTYm

YW1wO2lzYm49JmFtcDt2b2x1bWU9NzMmYW1wO2lzc3VlPTEmYW1wO3NwYWdlPTM0JmFtcDtwYWdl

cz0zNC00NCZhbXA7ZGF0ZT0yMDE2JmFtcDt0aXRsZT1Kb3VybmFsK29mK1BzeWNoaWF0cmljK1Jl

c2VhcmNoJmFtcDthdGl0bGU9QStyYW5kb21pemVkK2NvbnRyb2xsZWQrc3R1ZHkrb2YrdGhlK2Vm

ZmljYWN5K29mK3NpeC1tb250aCtzdXBwbGVtZW50YXRpb24rd2l0aCtjb25jZW50cmF0ZWQrZmlz

aCtvaWwrcmljaCtpbitvbWVnYS0zK3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkcytpbitmaXJz

dCtlcGlzb2RlK3NjaGl6b3BocmVuaWEuJmFtcDthdWxhc3Q9UGF3ZWxjenlrPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlJhdWNoPC9BdXRo

b3I+PFllYXI+MjAxMDwvWWVhcj48UmVjTnVtPjEzMjAzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4xMzIwMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjE2

Nzk3Ij4xMzIwMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UmF1Y2gs

IEIuPC9hdXRob3I+PGF1dGhvcj5TY2hpZWxlLCBSLjwvYXV0aG9yPjxhdXRob3I+U2NobmVpZGVy

LCBTLjwvYXV0aG9yPjxhdXRob3I+RGlsbGVyLCBGLjwvYXV0aG9yPjxhdXRob3I+VmljdG9yLCBO

LjwvYXV0aG9yPjxhdXRob3I+R29obGtlLCBILjwvYXV0aG9yPjxhdXRob3I+R290dHdpaywgTS48

L2F1dGhvcj48YXV0aG9yPlN0ZWluYmVjaywgRy48L2F1dGhvcj48YXV0aG9yPkRlbCBDYXN0aWxs

bywgVS48L2F1dGhvcj48YXV0aG9yPlNhY2ssIFIuPC9hdXRob3I+PGF1dGhvcj5Xb3J0aCwgSC48

L2F1dGhvcj48YXV0aG9yPkthdHVzLCBILjwvYXV0aG9yPjxhdXRob3I+U3BpdHplciwgVy48L2F1

dGhvcj48YXV0aG9yPlNhYmluLCBHLjwvYXV0aG9yPjxhdXRob3I+U2VuZ2VzLCBKLjwvYXV0aG9y

PjxhdXRob3I+R3JvdXAsIE9tZWdhIFN0dWR5PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+UmF1Y2gsQmVybmhhcmQuIEluc3RpdHV0IGZ1ciBIZXJ6aW5mYXJr

dGZvcnNjaHVuZyBMdWR3aWdzaGFmZW5hbiBkZXIgVW5pdmVyc2l0YXQgSGVpZGVsYmVyZywgR2Vy

bWFueS4gcmF1Y2hAemFyLWthcmRpby1sdWR3aWdzaGFmZW4uZGU8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5PTUVHQSwgYSByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgdHJpYWwg

dG8gdGVzdCB0aGUgZWZmZWN0IG9mIGhpZ2hseSBwdXJpZmllZCBvbWVnYS0zIGZhdHR5IGFjaWRz

IG9uIHRvcCBvZiBtb2Rlcm4gZ3VpZGVsaW5lLWFkanVzdGVkIHRoZXJhcHkgYWZ0ZXIgbXlvY2Fy

ZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmN1bGF0aW9uPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5DaXJjdWxhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNpcmN1bGF0aW9uPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9h

bHQtcGVyaW9kaWNhbD48cGFnZXM+MjE1Mi0yMTU5PC9wYWdlcz48dm9sdW1lPjEyMjwvdm9sdW1l

PjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50

LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQ29tYmluZWQgTW9kYWxpdHkgVGhlcmFw

eSBEZWF0aCxTdWRkZW4sQ2FyZGlhYy9lcCBbRXBpZGVtaW9sb2d5XSAqRGVhdGgsU3VkZGVuLENh

cmRpYWMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gKkZhdHR5IEFjaWRzLE9tZWdhLTMv

YWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmF0dHkgQWNpZHMsT21lZ2EtMy9hZSBb

QWR2ZXJzZSBFZmZlY3RzXSBGZW1hbGUgRm9sbG93LVVwIFN0dWRpZXMgRm9vZCBIYWJpdHMgSHVt

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTI0LTQ1Mzk8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMTYxL0NJ

UkNVTEFUSU9OQUhBLjExMC45NDg1NjI7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250

cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmst

dHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlk

d2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtE

PW1lZDUmYW1wO0FOPTIxMDYwMDcxaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1P

VklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjEwNjAwNzEmYW1wO2lkPWRvaToxMC4xMTYxJTJGQ0lS

Q1VMQVRJT05BSEEuMTEwLjk0ODU2MiZhbXA7aXNzbj0wMDA5LTczMjImYW1wO2lzYm49JmFtcDt2

b2x1bWU9MTIyJmFtcDtpc3N1ZT0yMSZhbXA7c3BhZ2U9MjE1MiZhbXA7cGFnZXM9MjE1Mi05JmFt

cDtkYXRlPTIwMTAmYW1wO3RpdGxlPUNpcmN1bGF0aW9uJmFtcDthdGl0bGU9T01FR0ElMkMrYSty

YW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCt0cmlhbCt0byt0ZXN0K3RoZStlZmZlY3Qr

b2YraGlnaGx5K3B1cmlmaWVkK29tZWdhLTMrZmF0dHkrYWNpZHMrb24rdG9wK29mK21vZGVybitn

dWlkZWxpbmUtYWRqdXN0ZWQrdGhlcmFweSthZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFt

cDthdWxhc3Q9UmF1Y2g8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+RGFuZ291cjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4z

NTA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4zNTA3PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRm

ZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTEzNDgiPjM1MDc8L2tleT48L2ZvcmVpZ24ta2V5cz48

cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y

cz48YXV0aG9ycz48YXV0aG9yPkRhbmdvdXIsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5BbGxlbiwg

RS48L2F1dGhvcj48YXV0aG9yPkVsYm91cm5lLCBELjwvYXV0aG9yPjxhdXRob3I+RmFzZXksIE4u

PC9hdXRob3I+PGF1dGhvcj5GbGV0Y2hlciwgQS4gRS48L2F1dGhvcj48YXV0aG9yPkhhcmR5LCBQ

LjwvYXV0aG9yPjxhdXRob3I+SG9sZGVyLCBHLiBFLjwvYXV0aG9yPjxhdXRob3I+S25pZ2h0LCBS

LjwvYXV0aG9yPjxhdXRob3I+TGV0bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHMsIE0u

PC9hdXRob3I+PGF1dGhvcj5VYXV5LCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkRhbmdvdXIsQWxhbiBELiBMb25kb24gU2Nob29sIG9mIEh5Z2llbmUg

YW5kIFRyb3BpY2FsIE1lZGljaW5lLCBVbml0ZWQgS2luZ2RvbS4gYWxhbi5kYW5nb3VyQGxzaHRt

LmFjLnVrICZsdDthbGFuLmRhbmdvdXJAbHNodG0uYWMudWsmZ3Q7PC9hdXRoLWFkZHJlc3M+PHRp

dGxlcz48dGl0bGU+RWZmZWN0IG9mIDIteSBuLTMgbG9uZy1jaGFpbiBwb2x5dW5zYXR1cmF0ZWQg

ZmF0dHkgYWNpZCBzdXBwbGVtZW50YXRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIG9sZGVy

IHBlb3BsZTogYSByYW5kb21pemVkLCBkb3VibGUtYmxpbmQsIGNvbnRyb2xsZWQgdHJpYWw8L3Rp

dGxlPjxzZWNvbmRhcnktdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRp

b248L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2xpbiBOdXRyPC9hbHQtdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGlu

aWNhbCBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBKIENsaW4gTnV0cjwvYWJici0x

PjxhYmJyLTI+VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9hYmJy

LTI+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbWVyaWNhbiBKb3Vy

bmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2xpbiBO

dXRyPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRy

aXRpb248L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNzI1LTE3MzI8L3BhZ2VzPjx2

b2x1bWU+OTE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJ

TiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkNvZ25pdGlv

bi9kZSBbRHJ1ZyBFZmZlY3RzXSBDb2duaXRpb24vcGggW1BoeXNpb2xvZ3ldIERpZXRhcnkgU3Vw

cGxlbWVudHMgRG91YmxlLUJsaW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRt

aW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS0zL2JsIFtCbG9vZF0g

RmVtYWxlIEh1bWFucyBNYWxlIE5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0cyBQYXRpZW50IENvbXBs

aWFuY2UgMCAoRmF0dHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVh

cj48L2RhdGVzPjxpc2JuPjE5MzgtMzIwNzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2ku

b3JnLzEwLjM5NDUvYWpjbi4yMDA5LjI5MTIxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBS

ZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZh

bXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0y

MDQxMDA4OWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFt

cDtpZD1wbWlkOjIwNDEwMDg5JmFtcDtpZD1kb2k6MTAuMzk0NSUyRmFqY24uMjAwOS4yOTEyMSZh

bXA7aXNzbj0wMDAyLTkxNjUmYW1wO2lzYm49JmFtcDt2b2x1bWU9OTEmYW1wO2lzc3VlPTYmYW1w

O3NwYWdlPTE3MjUmYW1wO3BhZ2VzPTE3MjUtMzImYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QW1l

cmljYW4rSm91cm5hbCtvZitDbGluaWNhbCtOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2Yr

Mi15K24tMytsb25nLWNoYWluK3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkK3N1cHBsZW1lbnRh

dGlvbitvbitjb2duaXRpdmUrZnVuY3Rpb24raW4rb2xkZXIrcGVvcGxlJTNBK2ErcmFuZG9taXpl

ZCUyQytkb3VibGUtYmxpbmQlMkMrY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1EYW5nb3Vy

PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PlNpbm48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+MTQ5MDk8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjE0OTA5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTc3NzIiPjE0OTA5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5TaW5uLCBOLjwvYXV0aG9yPjxhdXRob3I+TWlsdGUsIEMuIE0uPC9hdXRob3I+PGF1dGhv

cj5TdHJlZXQsIFMuIEouPC9hdXRob3I+PGF1dGhvcj5CdWNrbGV5LCBKLiBELjwvYXV0aG9yPjxh

dXRob3I+Q29hdGVzLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+UGV0a292LCBKLjwvYXV0aG9yPjxh

dXRob3I+SG93ZSwgUC4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5TaW5uLE5hdGFsaWUuIFNjaG9vbCBvZiBIZWFsdGggU2NpZW5jZXMsIFNhbnNvbSBJ

bnN0aXR1dGUgZm9yIEhlYWx0aCBSZXNlYXJjaCwgTnV0cml0aW9uYWwgUGh5c2lvbG9neSBSZXNl

YXJjaCBDZW50cmUsIFVuaXZlcnNpdHkgb2YgU291dGggQXVzdHJhbGlhLCBHUE8gQm94IDI0NzEs

IEFkZWxhaWRlLCBTQSA1MDAxLCBBdXN0cmFsaWEuIG5hdGFsaWUuc2lubkB1bmlzYS5lZHUuYXU8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FZmZlY3RzIG9mIG4tMyBmYXR0eSBhY2lkcywg

RVBBIHYuIERIQSwgb24gZGVwcmVzc2l2ZSBzeW1wdG9tcywgcXVhbGl0eSBvZiBsaWZlLCBtZW1v

cnkgYW5kIGV4ZWN1dGl2ZSBmdW5jdGlvbiBpbiBvbGRlciBhZHVsdHMgd2l0aCBtaWxkIGNvZ25p

dGl2ZSBpbXBhaXJtZW50OiBhIDYtbW9udGggcmFuZG9taXNlZCBjb250cm9sbGVkIHRyaWFsPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBOdXRyaXRpb248L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPkJyIEogTnV0cjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBOdXRyaXRpb248L2Z1bGwtdGl0

bGU+PGFiYnItMT5CciBKIE51dHI8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFi

YnItMT5CciBKIE51dHI8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNjgyLTE2OTM8

L3BhZ2VzPjx2b2x1bWU+MTA3PC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxyZXByaW50LWVk

aXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdl

ZCBBZ2VkLDgwIGFuZCBvdmVyIEF1c3RyYWxpYSBDb2duaXRpb24gRGlzb3JkZXJzL2JsIFtCbG9v

ZF0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZGggW0RpZXQgVGhlcmFweV0gQ29nbml0aW9uIERpc29y

ZGVycy9wcCBbUGh5c2lvcGF0aG9sb2d5XSBDb2duaXRpb24gRGlzb3JkZXJzL3B4IFtQc3ljaG9s

b2d5XSBEZXByZXNzaW9uL2JsIFtCbG9vZF0gKkRlcHJlc3Npb24vZGggW0RpZXQgVGhlcmFweV0g

RGVwcmVzc2lvbi9wcCBbUGh5c2lvcDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDEyPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTQ3NS0yNjYyPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDov

L2R4LmRvaS5vcmcvMTAuMTAxNy9TMDAwNzExNDUxMTAwNDc4ODtDb21wYXJhdGl2ZSBTdHVkeSBN

dWx0aWNlbnRlciBTdHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjE5Mjk4MzVodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MTkyOTgzNSZhbXA7aWQ9ZG9pOjEwLjEwMTclMkZTMDAwNzExNDUxMTAwNDc4OCZhbXA7aXNzbj0w

MDA3LTExNDUmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTA3JmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9

MTY4MiZhbXA7cGFnZXM9MTY4Mi05MyZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRsZT1Ccml0aXNoK0pv

dXJuYWwrb2YrTnV0cml0aW9uJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHkrYWNpZHMl

MkMrRVBBK3YuK0RIQSUyQytvbitkZXByZXNzaXZlK3N5bXB0b21zJTJDK3F1YWxpdHkrb2YrbGlm

ZSUyQyttZW1vcnkrYW5kK2V4ZWN1dGl2ZStmdW5jdGlvbitpbitvbGRlcithZHVsdHMrd2l0aCtt

aWxkK2NvZ25pdGl2ZStpbXBhaXJtZW50JTNBK2ErNi1tb250aCtyYW5kb21pc2VkK2NvbnRyb2xs

ZWQrdHJpYWwuJmFtcDthdWxhc3Q9U2lubjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HYWxhbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT41MjM2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41MjM2PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZm

c3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTIzMDAiPjUyMzY8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhbGFuLCBQLjwvYXV0aG9yPjxhdXRob3I+S2Vz

c2UtR3V5b3QsIEUuPC9hdXRob3I+PGF1dGhvcj5DemVybmljaG93LCBTLjwvYXV0aG9yPjxhdXRo

b3I+QnJpYW5jb24sIFMuPC9hdXRob3I+PGF1dGhvcj5CbGFjaGVyLCBKLjwvYXV0aG9yPjxhdXRo

b3I+SGVyY2JlcmcsIFMuPC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgU3UgRm9sIE9tIENvbGxhYm9y

YXRpdmU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5HYWxh

bixQaWxhci4gVU1SIFU1NTcgSW5zZXJtLCBVMTEyNSBJbnJhLCBDbmFtLCBVbml2ZXJzaXRlIFBh

cmlzIDEzLCBDUk5IIElkRiwgRi05MzAxNyBCb2JpZ255LCBGcmFuY2UuIHAuZ2FsYW5AdXJlbi5z

bWJoLnVuaXYtcGFyaXMxMy5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMg

b2YgQiB2aXRhbWlucyBhbmQgb21lZ2EgMyBmYXR0eSBhY2lkcyBvbiBjYXJkaW92YXNjdWxhciBk

aXNlYXNlczogYSByYW5kb21pc2VkIHBsYWNlYm8gY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5CTUo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJtajwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggTWVkaWNhbCBKb3Vy

bmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QnIgTWVkIEo8L2FiYnItMT48YWJici0yPkJNSjwvYWJi

ci0yPjxhYmJyLTM+Qm1qPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Ccml0aXNoIE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkJyIE1l

ZCBKPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0zPjwvYWx0

LXBlcmlvZGljYWw+PHBhZ2VzPmM2MjczPC9wYWdlcz48dm9sdW1lPjM0MTwvdm9sdW1lPjxyZXBy

aW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFuZ2luYSxVbnN0YWJsZS9kaCBbRGlldCBUaGVyYXB5

XSBCaW9tYXJrZXJzL2JsIFtCbG9vZF0gKkNhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzL3BjIFtQcmV2

ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJsaW5kIE1l

dGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtNi9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdl

XSBGYXR0eSBBY2lkcyxPbWVnYS02L2JsIFtCbG9vZF0gRjwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTc1Ni0xODMzPC9pc2JuPjx3b3Jr

LXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9ibWouYzYyNzM7TXVsdGljZW50ZXIgU3R1

ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTIxMTE1NTg5aHR0cDovL3NmeC51Y2wuYWMu

dWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjExMTU1ODkmYW1wO2lk

PWRvaToxMC4xMTM2JTJGYm1qLmM2MjczJmFtcDtpc3NuPTA5NTktNTM1WCZhbXA7aXNibj0mYW1w

O3ZvbHVtZT0zNDEmYW1wO2lzc3VlPTI5JmFtcDtzcGFnZT1jNjI3MyZhbXA7cGFnZXM9YzYyNzMm

YW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Qk1KJmFtcDthdGl0bGU9RWZmZWN0cytvZitCK3ZpdGFt

aW5zK2FuZCtvbWVnYSszK2ZhdHR5K2FjaWRzK29uK2NhcmRpb3Zhc2N1bGFyK2Rpc2Vhc2VzJTNB

K2ErcmFuZG9taXNlZCtwbGFjZWJvK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9R2FsYW48

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

QW5kcmlldTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051bT4yMTk5NDwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjE5OTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTU1MDA3Nzk4NiI+MjE5OTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkFuZHJpZXUsIFNhbmRyaW5lPC9hdXRob3I+PGF1dGhvcj5HdXlvbm5ldCwgU29waGll

PC9hdXRob3I+PGF1dGhvcj5Db2xleSwgTmljb2xhPC9hdXRob3I+PGF1dGhvcj5DYW50ZXQsIENo

cmlzdGVsbGU8L2F1dGhvcj48YXV0aG9yPkJvbm5lZm95LCBNYXJjPC9hdXRob3I+PGF1dGhvcj5C

b3JkZXMsIFNlcmdlPC9hdXRob3I+PGF1dGhvcj5Cb3JpZXMsIExhd3JlbmNlPC9hdXRob3I+PGF1

dGhvcj5DdWZpLCBNYXJpZS1Ob8OrbGxlPC9hdXRob3I+PGF1dGhvcj5EYW50b2luZSwgVGhpZXJy

eTwvYXV0aG9yPjxhdXRob3I+RGFydGlndWVzLCBKZWFuLUZyYW7Dp29pczwvYXV0aG9yPjxhdXRo

b3I+RGVzY2xhdXgsIEZyYW7Dp29pc2U8L2F1dGhvcj48YXV0aG9yPkdhYmVsbGUsIEF1ZHJleTwv

YXV0aG9yPjxhdXRob3I+R2FzbmllciwgWWFubmljazwvYXV0aG9yPjxhdXRob3I+UGVzY2UsIEFs

YWluPC9hdXRob3I+PGF1dGhvcj5TdWRyZXMsIEtyaXN0ZWw8L2F1dGhvcj48YXV0aG9yPlRvdWNo

b24sIEphY3F1ZXM8L2F1dGhvcj48YXV0aG9yPlJvYmVydCwgUGhpbGlwcGU8L2F1dGhvcj48YXV0

aG9yPlJvdWF1ZCwgT2xpdmllcjwvYXV0aG9yPjxhdXRob3I+TGVncmFuZCwgUGhpbGlwcGU8L2F1

dGhvcj48YXV0aG9yPlBheW91eCwgUGllcnJlPC9hdXRob3I+PGF1dGhvcj5DYXViZXJlLCBKZWFu

LVBhdWw8L2F1dGhvcj48YXV0aG9yPldlaW5lciwgTWljaGFlbDwvYXV0aG9yPjxhdXRob3I+Q2Fy

cmnDqSwgSXNhYmVsbGU8L2F1dGhvcj48YXV0aG9yPk91c3NldCwgUGllcnJlLUplYW48L2F1dGhv

cj48YXV0aG9yPlZlbGxhcywgQnJ1bm88L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGxvbmctdGVybSBvbWVnYSAzIHBvbHl1bnNhdHVyYXRl

ZCBmYXR0eSBhY2lkIHN1cHBsZW1lbnRhdGlvbiB3aXRoIG9yIHdpdGhvdXQgbXVsdGlkb21haW4g

aW50ZXJ2ZW50aW9uIG9uIGNvZ25pdGl2ZSBmdW5jdGlvbiBpbiBlbGRlcmx5IGFkdWx0cyB3aXRo

IG1lbW9yeSBjb21wbGFpbnRzIChNQVBUKTogYSByYW5kb21pc2VkLCBwbGFjZWJvLWNvbnRyb2xs

ZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VGhlIExhbmNldCBOZXVyb2xvZ3k8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaGUgTGFuY2V0

IE5ldXJvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkxhbmNldCBOZXVyb2w8L2FiYnItMT48YWJi

ci0yPlRoZSBMYW5jZXQuIE5ldXJvbG9neTwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+Mzc3

LTM4OTwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxkYXRlcz48

eWVhcj4yMDE3PC95ZWFyPjwvZGF0ZXM+PHB1Ymxpc2hlcj5FbHNldmllcjwvcHVibGlzaGVyPjxp

c2JuPjE0NzQtNDQyMjwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly9kb2ku

b3JnLzEwLjEwMTYvUzE0NzQtNDQyMigxNykzMDA0MC02PC91cmw+PC9yZWxhdGVkLXVybHM+PC91

cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5ET0k6IDEwLjEwMTYvUzE0NzQtNDQyMigxNykz

MDA0MC02PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48YWNjZXNzLWRhdGU+MjAxOS8wMi8xMzwv

YWNjZXNzLWRhdGU+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLTE0KTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxh

dXRob3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwg

R3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3Jv

bWhvdXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZl

cnNpdHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zh

c2N1bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxl

PjxhbHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48

YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+

VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+

PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNp

bmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08

L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJy

LTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwv

dm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9y

ZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBD

YXJkaW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIg

RGlzZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50

cyBEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVu

b2ljIEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBU

aGVyYXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRl

cz48aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDU2L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVk

IFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBw

b3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48

dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1w

O05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6

Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIw

OTI5MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00

NzkzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUm

YW1wO3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91

cm5hbCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFz

Y3VsYXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9t

aG91dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjI4MzA8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+Q2hldywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+

PGF1dGhvcj5BZ3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48

YXV0aG9yPkdyb2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1

dGhvcj48YXV0aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24g

b2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFs

cyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBI

ZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29y

cG9yYXRpb24sIFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2Yg

RXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBC

cmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9n

eSBTZWN0aW9uLCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRl

cyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBh

cnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhh

cnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9m

IEVwaWRlbWlvbG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBN

YXNzYWNodXNldHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJz

aXR5IG9mIFV0YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

RWZmZWN0IG9mIE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhl

ciBOdXRyaWVudCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJF

RFMyIFJhbmRvbWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFN

QTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGlj

YWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVy

aWNhbiBNZWRpY2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1

bWU+PG51bWJlcj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmlu

dC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3Jp

dGhtcyBBc2NvcmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2du

aXRpb24gQ29udGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJh

dGlvbiAmYW1wOyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMg

QWNpZHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhv

ZCAqRWljb3NhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9k

YXRlcz48aXNibj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8x

MC4xMDAxL2phbWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJv

bGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2Vi

LmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1l

ZGwmYW1wO0FOPTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklE

Om1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4y

MDE1Ljk2NzcmYW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7

aXNzdWU9OCZhbXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1w

O3RpdGxlPUpBTUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytM

dXRlaW4lMkZaZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitv

bitDb2duaXRpdmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1Ry

aWFsLiZhbXA7YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+

PC9DaXRlPjxDaXRlPjxBdXRob3I+QVNDRU5EIFN0dWR5IENvbGxhYm9yYXRpdmUgR3JvdXA8L0F1

dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNOdW0+MjE3MDE8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjIxNzAxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NDIx

NDA2MjkiPjIxNzAxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BU0NF

TkQgU3R1ZHkgQ29sbGFib3JhdGl2ZSBHcm91cCw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PHRpdGxlcz48dGl0bGU+RWZmZWN0cyBvZiBu4oiSMyBGYXR0eSBBY2lkIFN1cHBsZW1l

bnRzIGluIERpYWJldGVzIE1lbGxpdHVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldyBFbmds

YW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9mdWxsLXRp

dGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpNPC9hYmJyLTI+PGFi

YnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJici0zPjwvcGVyaW9k

aWNhbD48cGFnZXM+MTU0MC0xNTUwPC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1lPjxudW1iZXI+

MTY8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMTgv

MTAvMTg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPk1hc3NhY2h1c2V0dHMg

TWVkaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAyOC00NzkzPC9pc2JuPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwczovL2RvaS5vcmcvMTAuMTA1Ni9ORUpNb2ExODA0OTg5PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDU2

L05FSk1vYTE4MDQ5ODk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3MtZGF0ZT4yMDE4

LzExLzEzPC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EZXJvc2E8

L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+MTgzODI8L1JlY051bT48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE4MzgyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAzMDQxMzUiPjE4MzgyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5E

ZXJvc2EsIEcuPC9hdXRob3I+PGF1dGhvcj5DaWNlcm8sIEEuIEYuPC9hdXRob3I+PGF1dGhvcj5E

JmFwb3M7QW5nZWxvLCBBLjwvYXV0aG9yPjxhdXRob3I+Qm9yZ2hpLCBDLjwvYXV0aG9yPjxhdXRo

b3I+TWFmZmlvbGksIFAuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+

PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIFBVRkFzIG9uIGZhc3RpbmcgcGxhc21hIGdsdWNvc2UgYW5k

IGluc3VsaW4gcmVzaXN0YW5jZSBpbiBwYXRpZW50cyB3aXRoIGltcGFpcmVkIGZhc3RpbmcgZ2x1

Y29zZSBvciBpbXBhaXJlZCBnbHVjb3NlIHRvbGVyYW5jZTwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5CaW9GYWN0b3JzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+QmlvRmFjdG9ycyAoT3hmb3JkLCBFbmdsYW5kKTwvZnVsbC10aXRsZT48YWJici0xPkJp

b0ZhY3RvcnM8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjMxNi0zMjI8L3BhZ2VzPjx2b2x1

bWU+NDI8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48

L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EYW50aGlp

cjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xODMxNDwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTgzMTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDMwNDA5NyI+MTgzMTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkRhbnRoaWlyLCBWLjwvYXV0aG9yPjxhdXRob3I+SG9za2luZywgRC48L2F1dGhvcj48YXV0aG9y

PkJ1cm5zLCBOLiBSLjwvYXV0aG9yPjxhdXRob3I+V2lsc29uLCBDLjwvYXV0aG9yPjxhdXRob3I+

TmV0dGVsYmVjaywgVC48L2F1dGhvcj48YXV0aG9yPkNhbHZhcmVzaSwgRS48L2F1dGhvcj48YXV0

aG9yPmV0LCBhIGw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0

bGU+Q29nbml0aXZlIHBlcmZvcm1hbmNlIGluIG9sZGVyIGFkdWx0cyBpcyBpbnZlcnNlbHkgYXNz

b2NpYXRlZCB3aXRoIGZpc2ggY29uc3VtcHRpb24gYnV0IG5vdCBlcnl0aHJvY3l0ZSBtZW1icmFu

ZSBuLTMgZmF0dHkgYWNpZHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VGhlIEpvdXJuYWwgb2Yg

bnV0cml0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+Sm91cm5hbCBvZiBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KIE51dHI8L2FiYnIt

MT48YWJici0yPlRoZSBqb3VybmFsIG9mIG51dHJpdGlvbjwvYWJici0yPjwvcGVyaW9kaWNhbD48

cGFnZXM+MzExLTMyMDwvcGFnZXM+PHZvbHVtZT4xNDQ8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJl

cj48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5WZWxsYXM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNO

dW0+MTY2MTc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE2NjE3PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0

YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTg3NDIiPjE2NjE3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WZWxsYXMsIEIuPC9hdXRob3I+PGF1dGhvcj5DYXJy

aWUsIEkuPC9hdXRob3I+PGF1dGhvcj5HdXlvbm5ldCwgUy48L2F1dGhvcj48YXV0aG9yPlRvdWNo

b24sIEouPC9hdXRob3I+PGF1dGhvcj5EYW50b2luZSwgVC48L2F1dGhvcj48YXV0aG9yPkRhcnRp

Z3VlcywgSi4gRi48L2F1dGhvcj48YXV0aG9yPkN1ZmksIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5C

b3JkZXMsIFMuPC9hdXRob3I+PGF1dGhvcj5HYXNuaWVyLCBZLjwvYXV0aG9yPjxhdXRob3I+Um9i

ZXJ0LCBQLjwvYXV0aG9yPjxhdXRob3I+Qm9yaWVzLCBMLjwvYXV0aG9yPjxhdXRob3I+Um91YXVk

LCBPLjwvYXV0aG9yPjxhdXRob3I+RGVzY2xhdXgsIEYuPC9hdXRob3I+PGF1dGhvcj5TdWRyZXMs

IEsuPC9hdXRob3I+PGF1dGhvcj5Cb25uZWZveSwgTS48L2F1dGhvcj48YXV0aG9yPlBlc2NlLCBB

LjwvYXV0aG9yPjxhdXRob3I+Rm91Z2VyZSwgQi48L2F1dGhvcj48YXV0aG9yPkRlbHJpZXUsIEou

PC9hdXRob3I+PGF1dGhvcj5GYWlzYW50LCBDLjwvYXV0aG9yPjxhdXRob3I+TGFsYSwgRi48L2F1

dGhvcj48YXV0aG9yPkR1cHV5LCBDLjwvYXV0aG9yPjxhdXRob3I+Q2FudGV0LCBDLjwvYXV0aG9y

PjxhdXRob3I+Q29sZXksIE4uPC9hdXRob3I+PGF1dGhvcj5CZWxsZXZpbGxlLCBTLjwvYXV0aG9y

PjxhdXRob3I+V2lsbGlzLCBTLiBMLjwvYXV0aG9yPjxhdXRob3I+V2VpbmVyLCBNLiBXLjwvYXV0

aG9yPjxhdXRob3I+SmVhbiBPdXNzZXQsIFAuPC9hdXRob3I+PGF1dGhvcj5BbmRyaWV1LCBTLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPihWZWxsYXMpIElO

U0VSTSBVTVIgMTAyNywgVG91bG91c2UsIEZyYW5jZSAoVmVsbGFzLCBHdXlvbm5ldCwgQ29sZXkp

IFVuaXZlcnNpdHkgb2YgVG91bG91c2UgSUlJLCBUb3Vsb3VzZSwgRnJhbmNlIChWZWxsYXMsIExh

bGEsIEplYW4gT3Vzc2V0KSBDSFUgVG91bG91c2UsIFRvdWxvdXNlLCBGcmFuY2UgKENhcnJpZSwg

R3V5b25uZXQsIEZvdWdlcmUsIEZhaXNhbnQsIER1cHV5LCBDYW50ZXQsIEFuZHJpZXUpIFRvdWxv

dXNlRnJhbmNlIChHdXlvbm5ldCwgRHVwdXksIENhbnRldCwgQ29sZXkpIElOU0VSTSBVTVIgMTAy

NywgRnJhbmNlIChUb3VjaG9uKSBDSFUgTW9udHBlbGxpZXIsIE1vbnRwZWxsaWVyLCBGcmFuY2Ug

KERhbnRvaW5lKSBDSFUgTGltb2dlcywgTGltb2dlcywgRnJhbmNlIChEYXJ0aWd1ZXMpIElOU0VS

TSBVODk3LCBCb3JkZWF1eCwgRnJhbmNlIChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHks

IEJvcmRlYXV4LCBGcmFuY2UgKERhcnRpZ3VlcykgTWVtb3J5IGNvbnN1bHRhdGlvbiwgQ0hVIEJv

cmRlYXV4LCBCb3JkZWF1eCwgRnJhbmNlIChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHkg

SG9zcGl0YWwsIEJvcmRlYXV4LCBGcmFuY2UgKEN1ZmkpIENIIENhc3RyZXMsIENhc3RyZXMsIEZy

YW5jZSAoQm9yZGVzLCBHYXNuaWVyKSBDSCBUYXJiZXMsIFRhcmJlcywgRnJhbmNlIChSb2JlcnQp

IENIVSBOaWNlLCBOaWNlLCBGcmFuY2UgKEJvcmllcykgQ0ggRm9peCwgRm9peCwgRnJhbmNlIChS

b3VhdWQpIEhvcGl0YWwgR2VuZXJhbCwgRGlqb24sIEZyYW5jZSAoRGVzY2xhdXgpIENIIExhdmF1

ciwgTGF2YXVyLCBGcmFuY2UgKFN1ZHJlcykgQ0ggTW9udGF1YmFuLCBNb250YXViYW4sIEZyYW5j

ZSAoQm9ubmVmb3kpIENIVSBMeW9uIFNVRCwgTHlvbiwgRnJhbmNlIChQZXNjZSkgQ0ggUHJpbmNl

c3NlIEdyYWNlLCBNb25hY28sIE1vbmFjbyAoRGVscmlldSkgSW5zdGl0dXRlIG9mIEFnaW5nLCBV

bml2ZXJzaXR5IEhvc3BpdGFsIFRvdWxvdXNlLCBUb3Vsb3VzZSwgRnJhbmNlIChCZWxsZXZpbGxl

KSBJbnN0aXR1dCBVbml2ZXJzaXRhaXJlIERlIEdlcmlhdHJpZSBEZSBNb250cmVhbCwgTW9udHJl

YWwsIFFDLCBDYW5hZGEgKEJlbGxldmlsbGUpIFVuaXZlcnNpdGUgRGUgTW9udHJlYWwsIE1vbnRy

ZWFsLCBRQywgQ2FuYWRhIChXaWxsaXMpIEluZGlhbmEgVW5pdmVyc2l0eSwgSW5kaWFuYXBvbGlz

LCBJTiwgVW5pdGVkIFN0YXRlcyAoV2VpbmVyKSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEgU2Fu

IEZyYW5jaXNjbywgU2FuIEZyYW5jaXNjbywgQ0EsIFVuaXRlZCBTdGF0ZXMgKEFuZHJpZXUpIElO

U0VSTSBVTVIgMTAyNywgUGF1bCBTYWJhdGllciBVbml2ZXJzaXR5LCBUb3Vsb3VzZSwgRnJhbmNl

IEIuIFZlbGxhcywgSU5TRVJNIFVNUiAxMDI3LCBUb3Vsb3VzZSwgRnJhbmNlLiBFLW1haWw6IHZl

bGxhcy5iQGNodS10b3Vsb3VzZS5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1BUFQg

KG11bHRpLWRvbWFpbiBBbHpoZWltZXImYXBvcztzIHByZXZlbnRpb24gdHJpYWwpOiBSZXN1bHRz

IGF0IDM2IG1vbnRoczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbHpoZWltZXImYXBvcztzIGFu

ZCBEZW1lbnRpYTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkFsemhlaW1lciZhcG9zO3MgJmFtcDsgRGVtZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5B

bHpoZWltZXImYXBvcztzIGRlbWVudDwvYWJici0xPjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBh

bmQgRGVtZW50aWE8L2FiYnItMj48YWJici0zPkFsemhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJy

LTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMzE8L3BhZ2VzPjx2b2x1bWU+MSk8L3ZvbHVtZT48cmVw

cmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPnByZXZlbnRpb24gc3R1ZHkgaHVtYW4gY29nbml0aW9uIG1lbW9yeSBzYWZldHkgZGlnaXQg

c3ltYm9sIHN1YnN0aXR1dGlvbiB0ZXN0IGNsaW5pY2FsIHRyaWFsIGhvc3BpdGFsIHRyYWlsIG1h

a2luZyB0ZXN0IG51dHJpdGlvbiBwaHlzaWNhbCBhY3Rpdml0eSBvdXRwYXRpZW50IGFnZWQgc3Vw

cGxlbWVudGF0aW9uIGFkdWx0IFdlY2hzbGVyIGFkdWx0IGludGVsbGlnZW5jZSBzY2FsZSBNaW5p

IE1lbnRhbCBTdGF0ZSBFeGFtaW5hdGlvbiBvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxNTwveWVhcj48L2RhdGVzPjxpc2JuPjE1NTItNTI2MDwvaXNibj48d29yay10eXBl

PkNvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX

Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMyZhbXA7QU49NzIxMjQ1NzFodHRwOi8v

c2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtpZD1wbWlkOiZhbXA7

aWQ9ZG9pOiZhbXA7aXNzbj0xNTUyLTUyNjAmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTEmYW1wO2lz

c3VlPTcrU1VQUEwuKzEmYW1wO3NwYWdlPVAzMzEmYW1wO3BhZ2VzPVAzMzEmYW1wO2RhdGU9MjAx

NSZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3cythbmQrRGVtZW50aWEmYW1wO2F0aXRsZT1NQVBUKyUy

OG11bHRpLWRvbWFpbitBbHpoZWltZXIlMjdzK3ByZXZlbnRpb24rdHJpYWwlMjklM0ErUmVzdWx0

cythdCszNittb250aHMmYW1wO2F1bGFzdD1WZWxsYXM8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+WXVya28tTWF1cm88L0F1dGhvcj48WWVh

cj4yMDEwPC9ZZWFyPjxSZWNOdW0+MTc3MjQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE3

NzI0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBh

dzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTk0MTgiPjE3

NzI0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5ZdXJrby1NYXVybywg

Sy48L2F1dGhvcj48YXV0aG9yPk1jQ2FydGh5LCBELjwvYXV0aG9yPjxhdXRob3I+Um9tLCBELjwv

YXV0aG9yPjxhdXRob3I+TmVsc29uLCBFLiBCLjwvYXV0aG9yPjxhdXRob3I+UnlhbiwgQS4gUy48

L2F1dGhvcj48YXV0aG9yPkJsYWNrd2VsbCwgQS48L2F1dGhvcj48YXV0aG9yPlNhbGVtLCBOLiwg

SnIuPC9hdXRob3I+PGF1dGhvcj5TdGVkbWFuLCBNLjwvYXV0aG9yPjxhdXRob3I+SW52ZXN0aWdh

dG9ycywgTWlkYXM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5ZdXJrby1NYXVybyxLYXJpbi4gQ2xpbmljYWwgUmVzZWFyY2ggRGVwYXJ0bWVudCwgTWFydGVr

IEJpb3NjaWVuY2VzIENvcnBvcmF0aW9uLCBDb2x1bWJpYSwgTUQsIFVTQS4ga3l1cmtvQG1hcnRl

ay5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5CZW5lZmljaWFsIGVmZmVjdHMgb2Yg

ZG9jb3NhaGV4YWVub2ljIGFjaWQgb24gY29nbml0aW9uIGluIGFnZS1yZWxhdGVkIGNvZ25pdGl2

ZSBkZWNsaW5lPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFsemhlaW1lciZhcG9zO3MgJmFtcDsg

RGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFsemhlaW1lciZhcG9zO3MgZGVt

ZW50PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QWx6aGVpbWVy

JmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvZnVsbC10aXRsZT48YWJici0xPkFsemhlaW1lciZhcG9z

O3MgZGVtZW50PC9hYmJyLTE+PGFiYnItMj5BbHpoZWltZXImYXBvcztzIGFuZCBEZW1lbnRpYTwv

YWJici0yPjxhYmJyLTM+QWx6aGVpbWVycyBhbmQgRGVtZW50aWE8L2FiYnItMz48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFsemhlaW1lciZhcG9zO3MgJmFtcDsgRGVt

ZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbHpoZWltZXImYXBvcztzIGRlbWVudDwvYWJici0x

PjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L2FiYnItMj48YWJici0zPkFs

emhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NDU2

LTQ2NDwvcGFnZXM+PHZvbHVtZT42PC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PHJlcHJpbnQt

ZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5B

Z2VkICpBZ2luZy9kZSBbRHJ1ZyBFZmZlY3RzXSAqQWdpbmcvcHggW1BzeWNob2xvZ3ldICpDb2du

aXRpb24gRGlzb3JkZXJzL2RpIFtEaWFnbm9zaXNdIENvZ25pdGlvbiBEaXNvcmRlcnMvbWUgW01l

dGFib2xpc21dICpDb2duaXRpb24gRGlzb3JkZXJzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRy

b2xdIERlbWVudGlhL2RpIFtEaWFnbm9zaXNdIERlbWVudGlhL2R0IFtEcnVnIFRoZXJhcHldIERl

bWVudGlhL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE1NTItNTI3OTwvaXNibj48d29yay10

eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qYWx6LjIwMTAuMDEuMDEzO1JhbmRvbWl6

ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWRjJmFtcDtBTj0yMDQzNDk2MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2Nh

bD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDM0OTYxJmFtcDtpZD1kb2k6MTAuMTAx

NiUyRmouamFsei4yMDEwLjAxLjAxMyZhbXA7aXNzbj0xNTUyLTUyNjAmYW1wO2lzYm49JmFtcDt2

b2x1bWU9NiZhbXA7aXNzdWU9NiZhbXA7c3BhZ2U9NDU2JmFtcDtwYWdlcz00NTYtNjQmYW1wO2Rh

dGU9MjAxMCZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3cyslMjYrRGVtZW50aWEmYW1wO2F0aXRsZT1C

ZW5lZmljaWFsK2VmZmVjdHMrb2YrZG9jb3NhaGV4YWVub2ljK2FjaWQrb24rY29nbml0aW9uK2lu

K2FnZS1yZWxhdGVkK2NvZ25pdGl2ZStkZWNsaW5lLiZhbXA7YXVsYXN0PVl1cmtvLU1hdXJvPC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlBh

d2VsY3p5azwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4xMjQyMDwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTI0MjA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxNjM0MSI+MTI0MjA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPlBhd2VsY3p5aywgVC48L2F1dGhvcj48YXV0aG9yPkdyYW5jb3ctR3JhYmthLCBNLjwv

YXV0aG9yPjxhdXRob3I+S290bGlja2EtQW50Y3phaywgTS48L2F1dGhvcj48YXV0aG9yPlRyYWZh

bHNrYSwgRS48L2F1dGhvcj48YXV0aG9yPlBhd2VsY3p5aywgQS48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5QYXdlbGN6eWssVG9tYXN6LiBEZXBhcnRtZW50

IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywgTWVkaWNhbCBVbml2ZXJzaXR5

IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0yMTYgTG9keiwgUG9sYW5kLiBF

bGVjdHJvbmljIGFkZHJlc3M6IHRvbWFzei5wYXdlbGN6eWtAdW1lZC5sb2R6LnBsLiBHcmFuY293

LUdyYWJrYSxNYXJ0YS4gQ2VudHJhbCBUZWFjaGluZyBIb3NwaXRhbCwgTWVkaWNhbCBVbml2ZXJz

aXR5IG9mIExvZHosIHVsLiBQb21vcnNrYSAyNTEsIDkyLTIxMyBMb2R6LCBQb2xhbmQuIEVsZWN0

cm9uaWMgYWRkcmVzczogbWFydGFncmFuY293QGdtYWlsLmNvbS4gS290bGlja2EtQW50Y3phayxN

YWdkYWxlbmEuIERlcGFydG1lbnQgb2YgQWZmZWN0aXZlIGFuZCBQc3ljaG90aWMgRGlzb3JkZXJz

LCBNZWRpY2FsIFVuaXZlcnNpdHkgb2YgTG9keiwgdWwuIEN6ZWNob3Nsb3dhY2thIDgvMTAsIDky

LTIxNiBMb2R6LCBQb2xhbmQuIEVsZWN0cm9uaWMgYWRkcmVzczogbWFnZGFsZW5hLmtvdGxpY2th

LWFudGN6YWtAdW1lZC5sb2R6LnBsLiBUcmFmYWxza2EsRWx6YmlldGEuIERlcGFydG1lbnQgb2Yg

TnV0cml0aW9uIEh5Z2llbmUgYW5kIEVwaWRlbWlvbG9neSwgTWVkaWNhbCBVbml2ZXJzaXR5IG9m

IExvZHosIHVsLiBKYXJhY3phIDYzLCA5MC0yNTEgTG9keiwgUG9sYW5kLiBFbGVjdHJvbmljIGFk

ZHJlc3M6IGVsemJpZXRhLnRyYWZhbHNrYUB1bWVkLmxvZHoucGwuIFBhd2VsY3p5ayxBZ25pZXN6

a2EuIERlcGFydG1lbnQgb2YgQWZmZWN0aXZlIGFuZCBQc3ljaG90aWMgRGlzb3JkZXJzLCBNZWRp

Y2FsIFVuaXZlcnNpdHkgb2YgTG9keiwgdWwuIEN6ZWNob3Nsb3dhY2thIDgvMTAsIDkyLTIxNiBM

b2R6LCBQb2xhbmQuIEVsZWN0cm9uaWMgYWRkcmVzczogYWduaWVzemthLnBhd2VsY3p5a0B1bWVk

LmxvZHoucGw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BIHJhbmRvbWl6ZWQgY29udHJv

bGxlZCBzdHVkeSBvZiB0aGUgZWZmaWNhY3kgb2Ygc2l4LW1vbnRoIHN1cHBsZW1lbnRhdGlvbiB3

aXRoIGNvbmNlbnRyYXRlZCBmaXNoIG9pbCByaWNoIGluIG9tZWdhLTMgcG9seXVuc2F0dXJhdGVk

IGZhdHR5IGFjaWRzIGluIGZpcnN0IGVwaXNvZGUgc2NoaXpvcGhyZW5pYTwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Kb3VybmFsIG9mIFBzeWNoaWF0cmljIFJlc2VhcmNoPC9zZWNvbmRhcnktdGl0

bGU+PGFsdC10aXRsZT5KIFBzeWNoaWF0ciBSZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNoaWF0cmljIFJlc2VhcmNoPC9mdWxsLXRp

dGxlPjxhYmJyLTE+SiBQc3ljaGlhdHIgUmVzPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNoaWF0cmljIFJlc2VhcmNoPC9mdWxs

LXRpdGxlPjxhYmJyLTE+SiBQc3ljaGlhdHIgUmVzPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48

cGFnZXM+MzQtNDQ8L3BhZ2VzPjx2b2x1bWU+NzM8L3ZvbHVtZT48cmVwcmludC1lZGl0aW9uPk5P

VCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+PC9kYXRl

cz48aXNibj4xODc5LTEzNzk8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDE2L2ouanBzeWNoaXJlcy4yMDE1LjExLjAxMztSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH

b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1wcmVtJmFtcDtBTj0yNjY3OTc2M2h0dHA6Ly9zZngudWNsLmFjLnVr

L3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjI2Njc5NzYzJmFtcDtpZD1k

b2k6MTAuMTAxNiUyRmouanBzeWNoaXJlcy4yMDE1LjExLjAxMyZhbXA7aXNzbj0wMDIyLTM5NTYm

YW1wO2lzYm49JmFtcDt2b2x1bWU9NzMmYW1wO2lzc3VlPTEmYW1wO3NwYWdlPTM0JmFtcDtwYWdl

cz0zNC00NCZhbXA7ZGF0ZT0yMDE2JmFtcDt0aXRsZT1Kb3VybmFsK29mK1BzeWNoaWF0cmljK1Jl

c2VhcmNoJmFtcDthdGl0bGU9QStyYW5kb21pemVkK2NvbnRyb2xsZWQrc3R1ZHkrb2YrdGhlK2Vm

ZmljYWN5K29mK3NpeC1tb250aCtzdXBwbGVtZW50YXRpb24rd2l0aCtjb25jZW50cmF0ZWQrZmlz

aCtvaWwrcmljaCtpbitvbWVnYS0zK3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkcytpbitmaXJz

dCtlcGlzb2RlK3NjaGl6b3BocmVuaWEuJmFtcDthdWxhc3Q9UGF3ZWxjenlrPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlJhdWNoPC9BdXRo

b3I+PFllYXI+MjAxMDwvWWVhcj48UmVjTnVtPjEzMjAzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4xMzIwMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjE2

Nzk3Ij4xMzIwMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UmF1Y2gs

IEIuPC9hdXRob3I+PGF1dGhvcj5TY2hpZWxlLCBSLjwvYXV0aG9yPjxhdXRob3I+U2NobmVpZGVy

LCBTLjwvYXV0aG9yPjxhdXRob3I+RGlsbGVyLCBGLjwvYXV0aG9yPjxhdXRob3I+VmljdG9yLCBO

LjwvYXV0aG9yPjxhdXRob3I+R29obGtlLCBILjwvYXV0aG9yPjxhdXRob3I+R290dHdpaywgTS48

L2F1dGhvcj48YXV0aG9yPlN0ZWluYmVjaywgRy48L2F1dGhvcj48YXV0aG9yPkRlbCBDYXN0aWxs

bywgVS48L2F1dGhvcj48YXV0aG9yPlNhY2ssIFIuPC9hdXRob3I+PGF1dGhvcj5Xb3J0aCwgSC48

L2F1dGhvcj48YXV0aG9yPkthdHVzLCBILjwvYXV0aG9yPjxhdXRob3I+U3BpdHplciwgVy48L2F1

dGhvcj48YXV0aG9yPlNhYmluLCBHLjwvYXV0aG9yPjxhdXRob3I+U2VuZ2VzLCBKLjwvYXV0aG9y

PjxhdXRob3I+R3JvdXAsIE9tZWdhIFN0dWR5PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+UmF1Y2gsQmVybmhhcmQuIEluc3RpdHV0IGZ1ciBIZXJ6aW5mYXJr

dGZvcnNjaHVuZyBMdWR3aWdzaGFmZW5hbiBkZXIgVW5pdmVyc2l0YXQgSGVpZGVsYmVyZywgR2Vy

bWFueS4gcmF1Y2hAemFyLWthcmRpby1sdWR3aWdzaGFmZW4uZGU8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5PTUVHQSwgYSByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgdHJpYWwg

dG8gdGVzdCB0aGUgZWZmZWN0IG9mIGhpZ2hseSBwdXJpZmllZCBvbWVnYS0zIGZhdHR5IGFjaWRz

IG9uIHRvcCBvZiBtb2Rlcm4gZ3VpZGVsaW5lLWFkanVzdGVkIHRoZXJhcHkgYWZ0ZXIgbXlvY2Fy

ZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmN1bGF0aW9uPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5DaXJjdWxhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNpcmN1bGF0aW9uPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9h

bHQtcGVyaW9kaWNhbD48cGFnZXM+MjE1Mi0yMTU5PC9wYWdlcz48dm9sdW1lPjEyMjwvdm9sdW1l

PjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50

LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQ29tYmluZWQgTW9kYWxpdHkgVGhlcmFw

eSBEZWF0aCxTdWRkZW4sQ2FyZGlhYy9lcCBbRXBpZGVtaW9sb2d5XSAqRGVhdGgsU3VkZGVuLENh

cmRpYWMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gKkZhdHR5IEFjaWRzLE9tZWdhLTMv

YWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmF0dHkgQWNpZHMsT21lZ2EtMy9hZSBb

QWR2ZXJzZSBFZmZlY3RzXSBGZW1hbGUgRm9sbG93LVVwIFN0dWRpZXMgRm9vZCBIYWJpdHMgSHVt

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTI0LTQ1Mzk8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMTYxL0NJ

UkNVTEFUSU9OQUhBLjExMC45NDg1NjI7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250

cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmst

dHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlk

d2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtE

PW1lZDUmYW1wO0FOPTIxMDYwMDcxaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1P

VklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjEwNjAwNzEmYW1wO2lkPWRvaToxMC4xMTYxJTJGQ0lS

Q1VMQVRJT05BSEEuMTEwLjk0ODU2MiZhbXA7aXNzbj0wMDA5LTczMjImYW1wO2lzYm49JmFtcDt2

b2x1bWU9MTIyJmFtcDtpc3N1ZT0yMSZhbXA7c3BhZ2U9MjE1MiZhbXA7cGFnZXM9MjE1Mi05JmFt

cDtkYXRlPTIwMTAmYW1wO3RpdGxlPUNpcmN1bGF0aW9uJmFtcDthdGl0bGU9T01FR0ElMkMrYSty

YW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCt0cmlhbCt0byt0ZXN0K3RoZStlZmZlY3Qr

b2YraGlnaGx5K3B1cmlmaWVkK29tZWdhLTMrZmF0dHkrYWNpZHMrb24rdG9wK29mK21vZGVybitn

dWlkZWxpbmUtYWRqdXN0ZWQrdGhlcmFweSthZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFt

cDthdWxhc3Q9UmF1Y2g8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjxDaXRlPjxBdXRob3I+RGFuZ291cjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4z

NTA3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4zNTA3PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRm

ZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTEzNDgiPjM1MDc8L2tleT48L2ZvcmVpZ24ta2V5cz48

cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y

cz48YXV0aG9ycz48YXV0aG9yPkRhbmdvdXIsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5BbGxlbiwg

RS48L2F1dGhvcj48YXV0aG9yPkVsYm91cm5lLCBELjwvYXV0aG9yPjxhdXRob3I+RmFzZXksIE4u

PC9hdXRob3I+PGF1dGhvcj5GbGV0Y2hlciwgQS4gRS48L2F1dGhvcj48YXV0aG9yPkhhcmR5LCBQ

LjwvYXV0aG9yPjxhdXRob3I+SG9sZGVyLCBHLiBFLjwvYXV0aG9yPjxhdXRob3I+S25pZ2h0LCBS

LjwvYXV0aG9yPjxhdXRob3I+TGV0bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHMsIE0u

PC9hdXRob3I+PGF1dGhvcj5VYXV5LCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkRhbmdvdXIsQWxhbiBELiBMb25kb24gU2Nob29sIG9mIEh5Z2llbmUg

YW5kIFRyb3BpY2FsIE1lZGljaW5lLCBVbml0ZWQgS2luZ2RvbS4gYWxhbi5kYW5nb3VyQGxzaHRt

LmFjLnVrICZsdDthbGFuLmRhbmdvdXJAbHNodG0uYWMudWsmZ3Q7PC9hdXRoLWFkZHJlc3M+PHRp

dGxlcz48dGl0bGU+RWZmZWN0IG9mIDIteSBuLTMgbG9uZy1jaGFpbiBwb2x5dW5zYXR1cmF0ZWQg

ZmF0dHkgYWNpZCBzdXBwbGVtZW50YXRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIG9sZGVy

IHBlb3BsZTogYSByYW5kb21pemVkLCBkb3VibGUtYmxpbmQsIGNvbnRyb2xsZWQgdHJpYWw8L3Rp

dGxlPjxzZWNvbmRhcnktdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRp

b248L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2xpbiBOdXRyPC9hbHQtdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGlu

aWNhbCBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBKIENsaW4gTnV0cjwvYWJici0x

PjxhYmJyLTI+VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9hYmJy

LTI+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbWVyaWNhbiBKb3Vy

bmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2xpbiBO

dXRyPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRy

aXRpb248L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNzI1LTE3MzI8L3BhZ2VzPjx2

b2x1bWU+OTE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJ

TiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkNvZ25pdGlv

bi9kZSBbRHJ1ZyBFZmZlY3RzXSBDb2duaXRpb24vcGggW1BoeXNpb2xvZ3ldIERpZXRhcnkgU3Vw

cGxlbWVudHMgRG91YmxlLUJsaW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRt

aW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS0zL2JsIFtCbG9vZF0g

RmVtYWxlIEh1bWFucyBNYWxlIE5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0cyBQYXRpZW50IENvbXBs

aWFuY2UgMCAoRmF0dHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVh

cj48L2RhdGVzPjxpc2JuPjE5MzgtMzIwNzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2ku

b3JnLzEwLjM5NDUvYWpjbi4yMDA5LjI5MTIxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBS

ZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZh

bXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0y

MDQxMDA4OWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFt

cDtpZD1wbWlkOjIwNDEwMDg5JmFtcDtpZD1kb2k6MTAuMzk0NSUyRmFqY24uMjAwOS4yOTEyMSZh

bXA7aXNzbj0wMDAyLTkxNjUmYW1wO2lzYm49JmFtcDt2b2x1bWU9OTEmYW1wO2lzc3VlPTYmYW1w

O3NwYWdlPTE3MjUmYW1wO3BhZ2VzPTE3MjUtMzImYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QW1l

cmljYW4rSm91cm5hbCtvZitDbGluaWNhbCtOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2Yr

Mi15K24tMytsb25nLWNoYWluK3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkK3N1cHBsZW1lbnRh

dGlvbitvbitjb2duaXRpdmUrZnVuY3Rpb24raW4rb2xkZXIrcGVvcGxlJTNBK2ErcmFuZG9taXpl

ZCUyQytkb3VibGUtYmxpbmQlMkMrY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1EYW5nb3Vy

PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PlNpbm48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+MTQ5MDk8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjE0OTA5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTc3NzIiPjE0OTA5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5TaW5uLCBOLjwvYXV0aG9yPjxhdXRob3I+TWlsdGUsIEMuIE0uPC9hdXRob3I+PGF1dGhv

cj5TdHJlZXQsIFMuIEouPC9hdXRob3I+PGF1dGhvcj5CdWNrbGV5LCBKLiBELjwvYXV0aG9yPjxh

dXRob3I+Q29hdGVzLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+UGV0a292LCBKLjwvYXV0aG9yPjxh

dXRob3I+SG93ZSwgUC4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5TaW5uLE5hdGFsaWUuIFNjaG9vbCBvZiBIZWFsdGggU2NpZW5jZXMsIFNhbnNvbSBJ

bnN0aXR1dGUgZm9yIEhlYWx0aCBSZXNlYXJjaCwgTnV0cml0aW9uYWwgUGh5c2lvbG9neSBSZXNl

YXJjaCBDZW50cmUsIFVuaXZlcnNpdHkgb2YgU291dGggQXVzdHJhbGlhLCBHUE8gQm94IDI0NzEs

IEFkZWxhaWRlLCBTQSA1MDAxLCBBdXN0cmFsaWEuIG5hdGFsaWUuc2lubkB1bmlzYS5lZHUuYXU8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FZmZlY3RzIG9mIG4tMyBmYXR0eSBhY2lkcywg

RVBBIHYuIERIQSwgb24gZGVwcmVzc2l2ZSBzeW1wdG9tcywgcXVhbGl0eSBvZiBsaWZlLCBtZW1v

cnkgYW5kIGV4ZWN1dGl2ZSBmdW5jdGlvbiBpbiBvbGRlciBhZHVsdHMgd2l0aCBtaWxkIGNvZ25p

dGl2ZSBpbXBhaXJtZW50OiBhIDYtbW9udGggcmFuZG9taXNlZCBjb250cm9sbGVkIHRyaWFsPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBOdXRyaXRpb248L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPkJyIEogTnV0cjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBOdXRyaXRpb248L2Z1bGwtdGl0

bGU+PGFiYnItMT5CciBKIE51dHI8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkJyaXRpc2ggSm91cm5hbCBvZiBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFi

YnItMT5CciBKIE51dHI8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNjgyLTE2OTM8

L3BhZ2VzPjx2b2x1bWU+MTA3PC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxyZXByaW50LWVk

aXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdl

ZCBBZ2VkLDgwIGFuZCBvdmVyIEF1c3RyYWxpYSBDb2duaXRpb24gRGlzb3JkZXJzL2JsIFtCbG9v

ZF0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZGggW0RpZXQgVGhlcmFweV0gQ29nbml0aW9uIERpc29y

ZGVycy9wcCBbUGh5c2lvcGF0aG9sb2d5XSBDb2duaXRpb24gRGlzb3JkZXJzL3B4IFtQc3ljaG9s

b2d5XSBEZXByZXNzaW9uL2JsIFtCbG9vZF0gKkRlcHJlc3Npb24vZGggW0RpZXQgVGhlcmFweV0g

RGVwcmVzc2lvbi9wcCBbUGh5c2lvcDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDEyPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTQ3NS0yNjYyPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDov

L2R4LmRvaS5vcmcvMTAuMTAxNy9TMDAwNzExNDUxMTAwNDc4ODtDb21wYXJhdGl2ZSBTdHVkeSBN

dWx0aWNlbnRlciBTdHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjE5Mjk4MzVodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MTkyOTgzNSZhbXA7aWQ9ZG9pOjEwLjEwMTclMkZTMDAwNzExNDUxMTAwNDc4OCZhbXA7aXNzbj0w

MDA3LTExNDUmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTA3JmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9

MTY4MiZhbXA7cGFnZXM9MTY4Mi05MyZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRsZT1Ccml0aXNoK0pv

dXJuYWwrb2YrTnV0cml0aW9uJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHkrYWNpZHMl

MkMrRVBBK3YuK0RIQSUyQytvbitkZXByZXNzaXZlK3N5bXB0b21zJTJDK3F1YWxpdHkrb2YrbGlm

ZSUyQyttZW1vcnkrYW5kK2V4ZWN1dGl2ZStmdW5jdGlvbitpbitvbGRlcithZHVsdHMrd2l0aCtt

aWxkK2NvZ25pdGl2ZStpbXBhaXJtZW50JTNBK2ErNi1tb250aCtyYW5kb21pc2VkK2NvbnRyb2xs

ZWQrdHJpYWwuJmFtcDthdWxhc3Q9U2lubjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HYWxhbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT41MjM2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41MjM2PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZm

c3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTIzMDAiPjUyMzY8L2tleT48L2ZvcmVp

Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv

bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhbGFuLCBQLjwvYXV0aG9yPjxhdXRob3I+S2Vz

c2UtR3V5b3QsIEUuPC9hdXRob3I+PGF1dGhvcj5DemVybmljaG93LCBTLjwvYXV0aG9yPjxhdXRo

b3I+QnJpYW5jb24sIFMuPC9hdXRob3I+PGF1dGhvcj5CbGFjaGVyLCBKLjwvYXV0aG9yPjxhdXRo

b3I+SGVyY2JlcmcsIFMuPC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgU3UgRm9sIE9tIENvbGxhYm9y

YXRpdmU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5HYWxh

bixQaWxhci4gVU1SIFU1NTcgSW5zZXJtLCBVMTEyNSBJbnJhLCBDbmFtLCBVbml2ZXJzaXRlIFBh

cmlzIDEzLCBDUk5IIElkRiwgRi05MzAxNyBCb2JpZ255LCBGcmFuY2UuIHAuZ2FsYW5AdXJlbi5z

bWJoLnVuaXYtcGFyaXMxMy5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMg

b2YgQiB2aXRhbWlucyBhbmQgb21lZ2EgMyBmYXR0eSBhY2lkcyBvbiBjYXJkaW92YXNjdWxhciBk

aXNlYXNlczogYSByYW5kb21pc2VkIHBsYWNlYm8gY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5CTUo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJtajwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggTWVkaWNhbCBKb3Vy

bmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QnIgTWVkIEo8L2FiYnItMT48YWJici0yPkJNSjwvYWJi

ci0yPjxhYmJyLTM+Qm1qPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Ccml0aXNoIE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkJyIE1l

ZCBKPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0zPjwvYWx0

LXBlcmlvZGljYWw+PHBhZ2VzPmM2MjczPC9wYWdlcz48dm9sdW1lPjM0MTwvdm9sdW1lPjxyZXBy

aW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFuZ2luYSxVbnN0YWJsZS9kaCBbRGlldCBUaGVyYXB5

XSBCaW9tYXJrZXJzL2JsIFtCbG9vZF0gKkNhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzL3BjIFtQcmV2

ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJsaW5kIE1l

dGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtNi9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdl

XSBGYXR0eSBBY2lkcyxPbWVnYS02L2JsIFtCbG9vZF0gRjwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTc1Ni0xODMzPC9pc2JuPjx3b3Jr

LXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9ibWouYzYyNzM7TXVsdGljZW50ZXIgU3R1

ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTIxMTE1NTg5aHR0cDovL3NmeC51Y2wuYWMu

dWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjExMTU1ODkmYW1wO2lk

PWRvaToxMC4xMTM2JTJGYm1qLmM2MjczJmFtcDtpc3NuPTA5NTktNTM1WCZhbXA7aXNibj0mYW1w

O3ZvbHVtZT0zNDEmYW1wO2lzc3VlPTI5JmFtcDtzcGFnZT1jNjI3MyZhbXA7cGFnZXM9YzYyNzMm

YW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Qk1KJmFtcDthdGl0bGU9RWZmZWN0cytvZitCK3ZpdGFt

aW5zK2FuZCtvbWVnYSszK2ZhdHR5K2FjaWRzK29uK2NhcmRpb3Zhc2N1bGFyK2Rpc2Vhc2VzJTNB

K2ErcmFuZG9taXNlZCtwbGFjZWJvK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9R2FsYW48

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

QW5kcmlldTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051bT4yMTk5NDwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjE5OTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTU1MDA3Nzk4NiI+MjE5OTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkFuZHJpZXUsIFNhbmRyaW5lPC9hdXRob3I+PGF1dGhvcj5HdXlvbm5ldCwgU29waGll

PC9hdXRob3I+PGF1dGhvcj5Db2xleSwgTmljb2xhPC9hdXRob3I+PGF1dGhvcj5DYW50ZXQsIENo

cmlzdGVsbGU8L2F1dGhvcj48YXV0aG9yPkJvbm5lZm95LCBNYXJjPC9hdXRob3I+PGF1dGhvcj5C

b3JkZXMsIFNlcmdlPC9hdXRob3I+PGF1dGhvcj5Cb3JpZXMsIExhd3JlbmNlPC9hdXRob3I+PGF1

dGhvcj5DdWZpLCBNYXJpZS1Ob8OrbGxlPC9hdXRob3I+PGF1dGhvcj5EYW50b2luZSwgVGhpZXJy

eTwvYXV0aG9yPjxhdXRob3I+RGFydGlndWVzLCBKZWFuLUZyYW7Dp29pczwvYXV0aG9yPjxhdXRo

b3I+RGVzY2xhdXgsIEZyYW7Dp29pc2U8L2F1dGhvcj48YXV0aG9yPkdhYmVsbGUsIEF1ZHJleTwv

YXV0aG9yPjxhdXRob3I+R2FzbmllciwgWWFubmljazwvYXV0aG9yPjxhdXRob3I+UGVzY2UsIEFs

YWluPC9hdXRob3I+PGF1dGhvcj5TdWRyZXMsIEtyaXN0ZWw8L2F1dGhvcj48YXV0aG9yPlRvdWNo

b24sIEphY3F1ZXM8L2F1dGhvcj48YXV0aG9yPlJvYmVydCwgUGhpbGlwcGU8L2F1dGhvcj48YXV0

aG9yPlJvdWF1ZCwgT2xpdmllcjwvYXV0aG9yPjxhdXRob3I+TGVncmFuZCwgUGhpbGlwcGU8L2F1

dGhvcj48YXV0aG9yPlBheW91eCwgUGllcnJlPC9hdXRob3I+PGF1dGhvcj5DYXViZXJlLCBKZWFu

LVBhdWw8L2F1dGhvcj48YXV0aG9yPldlaW5lciwgTWljaGFlbDwvYXV0aG9yPjxhdXRob3I+Q2Fy

cmnDqSwgSXNhYmVsbGU8L2F1dGhvcj48YXV0aG9yPk91c3NldCwgUGllcnJlLUplYW48L2F1dGhv

cj48YXV0aG9yPlZlbGxhcywgQnJ1bm88L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGxvbmctdGVybSBvbWVnYSAzIHBvbHl1bnNhdHVyYXRl

ZCBmYXR0eSBhY2lkIHN1cHBsZW1lbnRhdGlvbiB3aXRoIG9yIHdpdGhvdXQgbXVsdGlkb21haW4g

aW50ZXJ2ZW50aW9uIG9uIGNvZ25pdGl2ZSBmdW5jdGlvbiBpbiBlbGRlcmx5IGFkdWx0cyB3aXRo

IG1lbW9yeSBjb21wbGFpbnRzIChNQVBUKTogYSByYW5kb21pc2VkLCBwbGFjZWJvLWNvbnRyb2xs

ZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VGhlIExhbmNldCBOZXVyb2xvZ3k8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5UaGUgTGFuY2V0

IE5ldXJvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkxhbmNldCBOZXVyb2w8L2FiYnItMT48YWJi

ci0yPlRoZSBMYW5jZXQuIE5ldXJvbG9neTwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+Mzc3

LTM4OTwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxkYXRlcz48

eWVhcj4yMDE3PC95ZWFyPjwvZGF0ZXM+PHB1Ymxpc2hlcj5FbHNldmllcjwvcHVibGlzaGVyPjxp

c2JuPjE0NzQtNDQyMjwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly9kb2ku

b3JnLzEwLjEwMTYvUzE0NzQtNDQyMigxNykzMDA0MC02PC91cmw+PC9yZWxhdGVkLXVybHM+PC91

cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5ET0k6IDEwLjEwMTYvUzE0NzQtNDQyMigxNykz

MDA0MC02PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48YWNjZXNzLWRhdGU+MjAxOS8wMi8xMzwv

YWNjZXNzLWRhdGU+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (2-14), including twelve LCn3 comparisons, and the single ALA assessment (Figure 1). Thirty trialsaG9vYixZYXNlci4gRW5kb2NyaW5vbG9neSBhbmQgTWV0YWJvbGlzbSBSZXNlYXJjaCBDZW50ZXIs

IFRlaHJhbiBVbml2ZXJzaXR5IG9mIE1lZGljYWwgU2NpZW5jZXMsIDV0aCBmbG9vciwgRHIgU2hh

cmVlYXRpIEhvc3BpdGFsLCBOb3J0aCBLYXJlZ2FyIEF2ZW51ZSwgVGVocmFuLCBJcmFuPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVmZmVjdCBvZiBsb3ctZG9zZSBvbWVnYSAzIGZh

dHR5IGFjaWRzIG9uIHRoZSB0cmVhdG1lbnQgb2YgbWlsZCB0byBtb2RlcmF0ZSBkZXByZXNzaW9u

IGluIHRoZSBlbGRlcmx5OiBhIGRvdWJsZS1ibGluZCwgcmFuZG9taXplZCwgcGxhY2Viby1jb250

cm9sbGVkIHN0dWR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9m

IFBzeWNoaWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5FdXIgQXJjaCBQc3ljaGlhdHJ5IENsaW4gTmV1cm9zY2k8L2FsdC10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBBcmNoaXZlcyBvZiBQc3lj

aGlhdHJ5ICZhbXA7IENsaW5pY2FsIE5ldXJvc2NpZW5jZTwvZnVsbC10aXRsZT48YWJici0xPkV1

ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWJici0xPjxhYmJyLTI+RXVyb3BlYW4g

QXJjaGl2ZXMgb2YgUHN5Y2hpYXRyeSBhbmQgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9hYmJyLTI+

PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBBcmNoaXZl

cyBvZiBQc3ljaGlhdHJ5ICZhbXA7IENsaW5pY2FsIE5ldXJvc2NpZW5jZTwvZnVsbC10aXRsZT48

YWJici0xPkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWJici0xPjxhYmJyLTI+

RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRyeSBhbmQgQ2xpbmljYWwgTmV1cm9zY2llbmNl

PC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NTM5LTU0OTwvcGFnZXM+PHZvbHVtZT4y

NjE8L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxF

PC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3Zl

ciBBbnRpZGVwcmVzc2l2ZSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkRlcHJlc3Npb24v

ZHQgW0RydWcgVGhlcmFweV0gRGlldCBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcgSHlwZXJzZW5z

aXRpdml0eSBGYXR0eSBBY2lkcyxPbWVnYS0zL2FlIFtBZHZlcnNlIEVmZmVjdHNdICpGYXR0eSBB

Y2lkcyxPbWVnYS0zL3R1IFtUaGVyYXBldXRpYyBVc2VdIEZlbWFsZSBGaXNoIE9pbHMvYWQgW0Fk

bWluaTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTQzMy04NDkxPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAw

Ny9zMDA0MDYtMDExLTAxOTEtOTtSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2gg

U3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1Z

JmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjEzMTg0NTJo

dHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1p

ZDoyMTMxODQ1MiZhbXA7aWQ9ZG9pOjEwLjEwMDclMkZzMDA0MDYtMDExLTAxOTEtOSZhbXA7aXNz

bj0wOTQwLTEzMzQmYW1wO2lzYm49JmFtcDt2b2x1bWU9MjYxJmFtcDtpc3N1ZT04JmFtcDtzcGFn

ZT01MzkmYW1wO3BhZ2VzPTUzOS00OSZhbXA7ZGF0ZT0yMDExJmFtcDt0aXRsZT1FdXJvcGVhbitB

cmNoaXZlcytvZitQc3ljaGlhdHJ5KyUyNitDbGluaWNhbCtOZXVyb3NjaWVuY2UmYW1wO2F0aXRs

ZT1UaGUrZWZmZWN0K29mK2xvdy1kb3NlK29tZWdhKzMrZmF0dHkrYWNpZHMrb24rdGhlK3RyZWF0

bWVudCtvZittaWxkK3RvK21vZGVyYXRlK2RlcHJlc3Npb24raW4rdGhlK2VsZGVybHklM0ErYStk

b3VibGUtYmxpbmQlMkMrcmFuZG9taXplZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrc3R1ZHkuJmFt

cDthdWxhc3Q9VGFqYWxpemFkZWtob29iPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlR1dHRsZTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+

PFJlY051bT4xNjI4NzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTYyODc8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBl

dmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxODU0OSI+MTYyODc8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlR1dHRsZSwgSy4gUi48L2F1dGhvcj48YXV0

aG9yPlNodWxlciwgTC4gQS48L2F1dGhvcj48YXV0aG9yPlBhY2thcmQsIEQuIFAuPC9hdXRob3I+

PGF1dGhvcj5NaWx0b24sIEouIEUuPC9hdXRob3I+PGF1dGhvcj5EYXJhdGhhLCBLLiBCLjwvYXV0

aG9yPjxhdXRob3I+QmlidXMsIEQuIE0uPC9hdXRob3I+PGF1dGhvcj5TaG9ydCwgUi4gQS48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UdXR0bGUsS2F0aGVy

aW5lIFIuIFRoZSBIZWFydCBJbnN0aXR1dGUgb2YgU3Bva2FuZSwgU2FjcmVkIEhlYXJ0IE1lZGlj

YWwgQ2VudGVyLCBTcG9rYW5lLCBXYXNoaW5ndG9uLCBVU0EuIGt0dXR0bGVAc2htYy5vcmc8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Db21wYXJpc29uIG9mIGxvdy1mYXQgdmVyc3VzIE1l

ZGl0ZXJyYW5lYW4tc3R5bGUgZGlldGFyeSBpbnRlcnZlbnRpb24gYWZ0ZXIgZmlyc3QgbXlvY2Fy

ZGlhbCBpbmZhcmN0aW9uIChmcm9tIFRoZSBIZWFydCBJbnN0aXR1dGUgb2YgU3Bva2FuZSBEaWV0

IEludGVydmVudGlvbiBhbmQgRXZhbHVhdGlvbiBUcmlhbCk8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5BbSBKIENhcmRpb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5B

bSBKIENhcmRpb2w8L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L2FiYnItMj48YWJici0zPlRoZSBhbWVyaWNhbiBqb3VybmFsIG9mIGNhcmRpb2xvZ3k8

L2FiYnItMz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2Fu

IEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwv

YWJici0xPjxhYmJyLTI+VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0y

PjxhYmJyLTM+VGhlIGFtZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvYWx0

LXBlcmlvZGljYWw+PHBhZ2VzPjE1MjMtMTUzMDwvcGFnZXM+PHZvbHVtZT4xMDE8L3ZvbHVtZT48

bnVtYmVyPjExPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5Db25maWRlbmNlIEludGVydmFscyAqRGlldCxGYXQt

UmVzdHJpY3RlZC9tdCBbTWV0aG9kc10gKkRpZXQsTWVkaXRlcnJhbmVhbiBEaXNlYXNlLUZyZWUg

U3Vydml2YWwgRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEh1bWFucyBNYWxlIE1pZGRsZSBBZ2Vk

ICpNeW9jYXJkaWFsIEluZmFyY3Rpb24vZGggW0RpZXQgVGhlcmFweV0gTXlvY2FyZGlhbCBJbmZh

cmN0aW9uL2VwIFtFcGlkZW1pb2xvZ3ldIE9kZHMgUmF0aW8gUmV0cm9zcGVjdGl2ZSBTPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PC9kYXRlcz48aXNibj4wMDAy

LTkxNDk8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYW1qY2Fy

ZC4yMDA4LjAxLjAzODtDb21wYXJhdGl2ZSBTdHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJp

YWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9

SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7

QU49MTg0ODk5MjdodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGlu

ZSZhbXA7aWQ9cG1pZDoxODQ4OTkyNyZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmFtamNhcmQuMjAw

OC4wMS4wMzgmYW1wO2lzc249MDAwMi05MTQ5JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTEwMSZhbXA7

aXNzdWU9MTEmYW1wO3NwYWdlPTE1MjMmYW1wO3BhZ2VzPTE1MjMtMzAmYW1wO2RhdGU9MjAwOCZh

bXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitDYXJkaW9sb2d5JmFtcDthdGl0bGU9Q29tcGFy

aXNvbitvZitsb3ctZmF0K3ZlcnN1cytNZWRpdGVycmFuZWFuLXN0eWxlK2RpZXRhcnkraW50ZXJ2

ZW50aW9uK2FmdGVyK2ZpcnN0K215b2NhcmRpYWwraW5mYXJjdGlvbislMjhmcm9tK1RoZStIZWFy

dCtJbnN0aXR1dGUrb2YrU3Bva2FuZStEaWV0K0ludGVydmVudGlvbithbmQrRXZhbHVhdGlvbitU

cmlhbCUyOS4mYW1wO2F1bGFzdD1UdXR0bGU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SHVudGluZ3RvbiBTdHVkeTwvQXV0aG9yPjxZZWFy

PjIwMDg8L1llYXI+PFJlY051bT43MTQzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43MTQz

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVq

cnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTMzNjgiPjcxNDM8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkh1bnRpbmd0b24gU3R1ZHkg

R3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlJh

bmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBvZiBldGh5bC1laWNvc2FwZW50YWVub2ljIGFjaWQg

aW4gSHVudGluZ3RvbiBkaXNlYXNlOiB0aGUgVFJFTkQtSEQgc3R1ZHk8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+QXJjaGl2ZXMgb2YgTmV1cm9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5BcmNoIE5ldXJvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFyY2ggTmV1cm9sPC9h

YmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoaXZlcyBv

ZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoIE5ldXJvbDwvYWJici0xPjwvYWx0

LXBlcmlvZGljYWw+PHBhZ2VzPjE1ODItMTU4OTwvcGFnZXM+PHZvbHVtZT42NTwvdm9sdW1lPjxu

dW1iZXI+MTI8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0IEFuYWx5c2lzIG9mIFZhcmlhbmNlIENhbmFk

YSBEb3VibGUtQmxpbmQgTWV0aG9kICpFaWNvc2FwZW50YWVub2ljIEFjaWQvYWEgW0FuYWxvZ3Mg

JmFtcDsgRGVyaXZhdGl2ZXNdIEVpY29zYXBlbnRhZW5vaWMgQWNpZC90dSBbVGhlcmFwZXV0aWMg

VXNlXSBGZW1hbGUgRm9sbG93LVVwIFN0dWRpZXMgSHVtYW5zICpIdW50aW5ndG9uIERpc2Vhc2Uv

ZHQgW0RydWcgVGhlcmFweV0gSHVudGluZ3RvbiBEaXNlYXNlL2dlIFtHZW5ldGljc10gKkh1PC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PC9kYXRlcz48aXNibj4x

NTM4LTM2ODc8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAxL2FyY2hu

ZXVyLjY1LjEyLjE1ODI7Q2xpbmljYWwgVHJpYWwgTXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXpl

ZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8

L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNv

bS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0

JmFtcDtEPW1lZDUmYW1wO0FOPTE5MDY0NzQ1aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2Fs

P3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTkwNjQ3NDUmYW1wO2lkPWRvaToxMC4xMDAx

JTJGYXJjaG5ldXIuNjUuMTIuMTU4MiZhbXA7aXNzbj0wMDAzLTk5NDImYW1wO2lzYm49JmFtcDt2

b2x1bWU9NjUmYW1wO2lzc3VlPTEyJmFtcDtzcGFnZT0xNTgyJmFtcDtwYWdlcz0xNTgyLTkmYW1w

O2RhdGU9MjAwOCZhbXA7dGl0bGU9QXJjaGl2ZXMrb2YrTmV1cm9sb2d5JmFtcDthdGl0bGU9UmFu

ZG9taXplZCtjb250cm9sbGVkK3RyaWFsK29mK2V0aHlsLWVpY29zYXBlbnRhZW5vaWMrYWNpZCtp

bitIdW50aW5ndG9uK2Rpc2Vhc2UlM0ErdGhlK1RSRU5ELUhEK3N0dWR5LiZhbXA7YXVsYXN0PUh1

bnRpbmd0b24rU3R1ZHkrR3JvdXArVFJFTkQtSEQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QVNDRU5EIFN0dWR5IENvbGxhYm9yYXRpdmUg

R3JvdXA8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNOdW0+MjE3MDE8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjIxNzAxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1NDIxNDA2MjkiPjIxNzAxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5BU0NFTkQgU3R1ZHkgQ29sbGFib3JhdGl2ZSBHcm91cCw8L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+RWZmZWN0cyBvZiBu4oiSMyBGYXR0eSBBY2lk

IFN1cHBsZW1lbnRzIGluIERpYWJldGVzIE1lbGxpdHVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

Pk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5l

PC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpNPC9h

YmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJici0z

PjwvcGVyaW9kaWNhbD48cGFnZXM+MTU0MC0xNTUwPC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1l

PjxudW1iZXI+MTY8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxk

YXRlPjIwMTgvMTAvMTg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPk1hc3Nh

Y2h1c2V0dHMgTWVkaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAyOC00NzkzPC9pc2Ju

Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL2RvaS5vcmcvMTAuMTA1Ni9ORUpNb2Ex

ODA0OTg5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMDU2L05FSk1vYTE4MDQ5ODk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3Mt

ZGF0ZT4yMDE4LzExLzEzPC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5BbmRyaWV1PC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVjTnVtPjIxOTk0PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4yMTk5NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGlt

ZXN0YW1wPSIxNTUwMDc3OTg2Ij4yMTk5NDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+QW5kcmlldSwgU2FuZHJpbmU8L2F1dGhvcj48YXV0aG9yPkd1eW9ubmV0LCBTb3Bo

aWU8L2F1dGhvcj48YXV0aG9yPkNvbGV5LCBOaWNvbGE8L2F1dGhvcj48YXV0aG9yPkNhbnRldCwg

Q2hyaXN0ZWxsZTwvYXV0aG9yPjxhdXRob3I+Qm9ubmVmb3ksIE1hcmM8L2F1dGhvcj48YXV0aG9y

PkJvcmRlcywgU2VyZ2U8L2F1dGhvcj48YXV0aG9yPkJvcmllcywgTGF3cmVuY2U8L2F1dGhvcj48

YXV0aG9yPkN1ZmksIE1hcmllLU5vw6tsbGU8L2F1dGhvcj48YXV0aG9yPkRhbnRvaW5lLCBUaGll

cnJ5PC9hdXRob3I+PGF1dGhvcj5EYXJ0aWd1ZXMsIEplYW4tRnJhbsOnb2lzPC9hdXRob3I+PGF1

dGhvcj5EZXNjbGF1eCwgRnJhbsOnb2lzZTwvYXV0aG9yPjxhdXRob3I+R2FiZWxsZSwgQXVkcmV5

PC9hdXRob3I+PGF1dGhvcj5HYXNuaWVyLCBZYW5uaWNrPC9hdXRob3I+PGF1dGhvcj5QZXNjZSwg

QWxhaW48L2F1dGhvcj48YXV0aG9yPlN1ZHJlcywgS3Jpc3RlbDwvYXV0aG9yPjxhdXRob3I+VG91

Y2hvbiwgSmFjcXVlczwvYXV0aG9yPjxhdXRob3I+Um9iZXJ0LCBQaGlsaXBwZTwvYXV0aG9yPjxh

dXRob3I+Um91YXVkLCBPbGl2aWVyPC9hdXRob3I+PGF1dGhvcj5MZWdyYW5kLCBQaGlsaXBwZTwv

YXV0aG9yPjxhdXRob3I+UGF5b3V4LCBQaWVycmU8L2F1dGhvcj48YXV0aG9yPkNhdWJlcmUsIEpl

YW4tUGF1bDwvYXV0aG9yPjxhdXRob3I+V2VpbmVyLCBNaWNoYWVsPC9hdXRob3I+PGF1dGhvcj5D

YXJyacOpLCBJc2FiZWxsZTwvYXV0aG9yPjxhdXRob3I+T3Vzc2V0LCBQaWVycmUtSmVhbjwvYXV0

aG9yPjxhdXRob3I+VmVsbGFzLCBCcnVubzwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48dGl0bGVzPjx0aXRsZT5FZmZlY3Qgb2YgbG9uZy10ZXJtIG9tZWdhIDMgcG9seXVuc2F0dXJh

dGVkIGZhdHR5IGFjaWQgc3VwcGxlbWVudGF0aW9uIHdpdGggb3Igd2l0aG91dCBtdWx0aWRvbWFp

biBpbnRlcnZlbnRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIGVsZGVybHkgYWR1bHRzIHdp

dGggbWVtb3J5IGNvbXBsYWludHMgKE1BUFQpOiBhIHJhbmRvbWlzZWQsIHBsYWNlYm8tY29udHJv

bGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaGUgTGFuY2V0IE5ldXJvbG9neTwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRoZSBMYW5j

ZXQgTmV1cm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+TGFuY2V0IE5ldXJvbDwvYWJici0xPjxh

YmJyLTI+VGhlIExhbmNldC4gTmV1cm9sb2d5PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4z

NzctMzg5PC9wYWdlcz48dm9sdW1lPjE2PC92b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGRhdGVz

Pjx5ZWFyPjIwMTc8L3llYXI+PC9kYXRlcz48cHVibGlzaGVyPkVsc2V2aWVyPC9wdWJsaXNoZXI+

PGlzYm4+MTQ3NC00NDIyPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL2Rv

aS5vcmcvMTAuMTAxNi9TMTQ3NC00NDIyKDE3KTMwMDQwLTY8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPkRPSTogMTAuMTAxNi9TMTQ3NC00NDIyKDE3

KTMwMDQwLTY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3MtZGF0ZT4yMDE5LzAyLzEz

PC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLTMzKTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxh

dXRob3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwg

R3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3Jv

bWhvdXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZl

cnNpdHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zh

c2N1bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxl

PjxhbHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48

YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+

VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+

PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNp

bmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08

L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJy

LTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwv

dm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9y

ZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBD

YXJkaW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIg

RGlzZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50

cyBEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVu

b2ljIEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBU

aGVyYXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRl

cz48aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDU2L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVk

IFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBw

b3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48

dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1w

O05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6

Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIw

OTI5MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00

NzkzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUm

YW1wO3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91

cm5hbCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFz

Y3VsYXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9t

aG91dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjI4MzA8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+Q2hldywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+

PGF1dGhvcj5BZ3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48

YXV0aG9yPkdyb2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1

dGhvcj48YXV0aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24g

b2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFs

cyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBI

ZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29y

cG9yYXRpb24sIFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2Yg

RXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBC

cmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9n

eSBTZWN0aW9uLCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRl

cyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBh

cnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhh

cnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9m

IEVwaWRlbWlvbG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBN

YXNzYWNodXNldHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJz

aXR5IG9mIFV0YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

RWZmZWN0IG9mIE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhl

ciBOdXRyaWVudCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJF

RFMyIFJhbmRvbWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFN

QTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGlj

YWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVy

aWNhbiBNZWRpY2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1

bWU+PG51bWJlcj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmlu

dC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3Jp

dGhtcyBBc2NvcmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2du

aXRpb24gQ29udGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJh

dGlvbiAmYW1wOyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMg

QWNpZHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhv

ZCAqRWljb3NhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9k

YXRlcz48aXNibj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8x

MC4xMDAxL2phbWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJv

bGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2Vi

LmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1l

ZGwmYW1wO0FOPTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklE

Om1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4y

MDE1Ljk2NzcmYW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7

aXNzdWU9OCZhbXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1w

O3RpdGxlPUpBTUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytM

dXRlaW4lMkZaZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitv

bitDb2duaXRpdmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1Ry

aWFsLiZhbXA7YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+

PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hpdTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJlY051

bT4yODYyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yODYyPC9yZWMtbnVtYmVyPjxmb3Jl

aWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0

dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTEwMDAiPjI4NjI8L2tleT48L2ZvcmVpZ24ta2V5

cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1

dG9ycz48YXV0aG9ycz48YXV0aG9yPkNoaXUsIEMuIEMuPC9hdXRob3I+PGF1dGhvcj5TdSwgSy4g

UC48L2F1dGhvcj48YXV0aG9yPkNoZW5nLCBULiBDLjwvYXV0aG9yPjxhdXRob3I+TGl1LCBILiBD

LjwvYXV0aG9yPjxhdXRob3I+Q2hhbmcsIEMuIEouPC9hdXRob3I+PGF1dGhvcj5EZXdleSwgTS4g

RS48L2F1dGhvcj48YXV0aG9yPlN0ZXdhcnQsIFIuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywgUy4g

WS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DaGl1LENo

aWgtQ2hpYW5nLiBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnksIFRhaXBlaSBDaXR5IFBzeWNoaWF0

cmljIENlbnRlciwgVGFpcGVpIENpdHkgSG9zcGl0YWwsIERlcGFydG1lbnQgb2YgUHN5Y2hpYXRy

eSwgVGFpcGVpIE1lZGljYWwgVW5pdmVyc2l0eSwgVGFpcGVpLCBUYWl3YW48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0cyBvZiBvbWVnYS0zIGZhdHR5IGFjaWRzIG1vbm90

aGVyYXB5IGluIEFsemhlaW1lciZhcG9zO3MgZGlzZWFzZSBhbmQgbWlsZCBjb2duaXRpdmUgaW1w

YWlybWVudDogYSBwcmVsaW1pbmFyeSByYW5kb21pemVkIGRvdWJsZS1ibGluZCBwbGFjZWJvLWNv

bnRyb2xsZWQgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UHJvZ3Jlc3MgaW4gTmV1cm8t

UHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7IEJpb2xvZ2ljYWwgUHN5Y2hpYXRyeTwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNvbCBCaW9sIFBzeWNoaWF0

cnk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Qcm9ncmVzcyBp

biBOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3kgJmFtcDsgQmlvbG9naWNhbCBQc3ljaGlhdHJ5PC9m

dWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNvbCBCaW9sIFBzeWNoaWF0

cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlByb2dy

ZXNzIGluIE5ldXJvLVBzeWNob3BoYXJtYWNvbG9neSAmYW1wOyBCaW9sb2dpY2FsIFBzeWNoaWF0

cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5Qcm9nIE5ldXJvcHN5Y2hvcGhhcm1hY29sIEJpb2wgUHN5

Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE1MzgtMTU0NDwvcGFnZXM+

PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9U

IElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgw

IGFuZCBvdmVyIEFsemhlaW1lciBEaXNlYXNlL2JsIFtCbG9vZF0gKkFsemhlaW1lciBEaXNlYXNl

L2R0IFtEcnVnIFRoZXJhcHldIEFsemhlaW1lciBEaXNlYXNlL3B4IFtQc3ljaG9sb2d5XSBDb2du

aXRpb24gRGlzb3JkZXJzL2JsIFtCbG9vZF0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZHQgW0RydWcg

VGhlcmFweV0gQ29nbml0aW9uIERpc29yZGVycy9weCBbUHN5Y2hvbG9neV0gRG91YmxlLUJsaW5k

IE1ldGhvZCBFaWNvczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFy

PjwvZGF0ZXM+PGlzYm4+MDI3OC01ODQ2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5v

cmcvMTAuMTAxNi9qLnBucGJwLjIwMDguMDUuMDE1O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtB

Tj0xODU3MzU4NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjE4NTczNTg1JmFtcDtpZD1kb2k6MTAuMTAxNiUyRmoucG5wYnAuMjAwOC4w

NS4wMTUmYW1wO2lzc249MDI3OC01ODQ2JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMyJmFtcDtpc3N1

ZT02JmFtcDtzcGFnZT0xNTM4JmFtcDtwYWdlcz0xNTM4LTQ0JmFtcDtkYXRlPTIwMDgmYW1wO3Rp

dGxlPVByb2dyZXNzK2luK05ldXJvLVBzeWNob3BoYXJtYWNvbG9neSslMjYrQmlvbG9naWNhbCtQ

c3ljaGlhdHJ5JmFtcDthdGl0bGU9VGhlK2VmZmVjdHMrb2Yrb21lZ2EtMytmYXR0eSthY2lkcytt

b25vdGhlcmFweStpbitBbHpoZWltZXIlMjdzK2Rpc2Vhc2UrYW5kK21pbGQrY29nbml0aXZlK2lt

cGFpcm1lbnQlM0ErYStwcmVsaW1pbmFyeStyYW5kb21pemVkK2RvdWJsZS1ibGluZCtwbGFjZWJv

LWNvbnRyb2xsZWQrc3R1ZHkuJmFtcDthdWxhc3Q9Q2hpdTwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CdXJyPC9BdXRob3I+PFllYXI+MjAw

MzwvWWVhcj48UmVjTnVtPjE4NzE2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xODcxNjwv

cmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2

c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMzUzNDgwIj4xODcxNjwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnVyciwgTS4gTC48L2F1dGhv

cj48YXV0aG9yPkFzaGZpZWxkLVdhdHQsIFAuIEEuPC9hdXRob3I+PGF1dGhvcj5EdW5zdGFuLCBG

LiBELjwvYXV0aG9yPjxhdXRob3I+RmVoaWx5LCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+QnJlYXks

IFAuPC9hdXRob3I+PGF1dGhvcj5Bc2h0b24sIFQuPC9hdXRob3I+PGF1dGhvcj5ldCwgYSBsPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkxhY2sgb2YgYmVu

ZWZpdCBvZiBkaWV0YXJ5IGFkdmljZSB0byBtZW4gd2l0aCBhbmdpbmE6IHJlc3VsdHMgb2YgYSBj

b250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwg

b2YgQ2xpbmljYWwgTnV0cml0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2Z1

bGwtdGl0bGU+PGFiYnItMT5FdXIgSiBDbGluIE51dHI8L2FiYnItMT48L3BlcmlvZGljYWw+PHBh

Z2VzPjE5My0yMDA8L3BhZ2VzPjx2b2x1bWU+NTc8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48

ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48L2RhdGVzPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uYXR1cmUuY29tL2FydGljbGVzLzE2MDE1MzkucGRmPC91cmw+PC9yZWxhdGVk

LXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkRlcm9zYTwvQXV0aG9y

PjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4xODM4MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i

ZXI+MTgzODI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1

Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDMwNDEz

NSI+MTgzODI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkRlcm9zYSwg

Ry48L2F1dGhvcj48YXV0aG9yPkNpY2VybywgQS4gRi48L2F1dGhvcj48YXV0aG9yPkQmYXBvcztB

bmdlbG8sIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3JnaGksIEMuPC9hdXRob3I+PGF1dGhvcj5NYWZm

aW9saSwgUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

RWZmZWN0cyBvZiBuLTMgUFVGQXMgb24gZmFzdGluZyBwbGFzbWEgZ2x1Y29zZSBhbmQgaW5zdWxp

biByZXNpc3RhbmNlIGluIHBhdGllbnRzIHdpdGggaW1wYWlyZWQgZmFzdGluZyBnbHVjb3NlIG9y

IGltcGFpcmVkIGdsdWNvc2UgdG9sZXJhbmNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJpb0Zh

Y3RvcnM8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5C

aW9GYWN0b3JzIChPeGZvcmQsIEVuZ2xhbmQpPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmlvRmFjdG9y

czwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MzE2LTMyMjwvcGFnZXM+PHZvbHVtZT40Mjwv

dm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+

PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlRva3Vkb21lPC9BdXRo

b3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjE2MDUxPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4xNjA1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjE4

NDA4Ij4xNjA1MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VG9rdWRv

bWUsIFMuPC9hdXRob3I+PGF1dGhvcj5LdXJpa2ksIEsuPC9hdXRob3I+PGF1dGhvcj5Zb2tveWFt

YSwgWS48L2F1dGhvcj48YXV0aG9yPlNhc2FraSwgTS48L2F1dGhvcj48YXV0aG9yPkpvaCwgVC48

L2F1dGhvcj48YXV0aG9yPkthbWl5YSwgVC48L2F1dGhvcj48YXV0aG9yPkNoZW5nLCBKLjwvYXV0

aG9yPjxhdXRob3I+T2dhd2EsIEsuPC9hdXRob3I+PGF1dGhvcj5TaGlyYWksIFQuPC9hdXRob3I+

PGF1dGhvcj5JbWFlZGEsIE4uPC9hdXRob3I+PGF1dGhvcj5Hb3RvLCBDLjwvYXV0aG9yPjxhdXRo

b3I+VG9rdWRvbWUsIFkuPC9hdXRob3I+PGF1dGhvcj5JY2hpa2F3YSwgSC48L2F1dGhvcj48YXV0

aG9yPk9rdXlhbWEsIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFk

ZHJlc3M+VG9rdWRvbWUsU2hpbmthbi4gRGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBOYWdv

eWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBN

aXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IE5hdGlvbmFsIEluc3RpdHV0ZSBvZiBIZWFsdGggYW5k

IE51dHJpdGlvbiwgU2hpbmp1a3Uta3UsIFRva3lvLCBKYXBhbjsgU29jaWFsIFdlbGZhcmUgSW5z

dGl0dXRpb25zIFNlaXphbnJpLWthaSwgQml3YWppbWEgQ2FyZSBDZW50ZXIsIE5pc2hpLWt1LCBO

YWdveWEsIEphcGFuLiBFbGVjdHJvbmljIGFkZHJlc3M6IHRva3Vkb21lMjAxM0BnbWFpbC5jb20u

IEt1cmlraSxLaXlvbm9yaS4gRGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBOYWdveWEgQ2l0

eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8t

a3UsIE5hZ295YSwgSmFwYW47IERlcGFydG1lbnQgb2YgTnV0cml0aW9uIGFuZCBIZWFsdGggU2Np

ZW5jZXMsIFVuaXZlcnNpdHkgb2YgU2hpenVva2EsIFN1cnVnYS1rdSwgU2hpenVva2EsIEphcGFu

LiBZb2tveWFtYSxZb3NoaWZ1bWkuIERlcGFydG1lbnQgb2YgR2FzdHJvZW50ZXJvbG9neSBhbmQg

TWV0YWJvbGlzbSwgTmFnb3lhIENpdHkgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVk

aWNhbCBTY2llbmNlcywgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuOyBOYWdveWEgTWVkaWNhbCBB

c3NvY2lhdGlvbiBIZWFsdGggQ2FyZSBDZW50ZXIsIEhpZ2FzaGkta3UsIE5hZ295YSwgSmFwYW4u

IFNhc2FraSxNYWtvdG8uIERlcGFydG1lbnQgb2YgR2FzdHJvZW50ZXJvbG9neSBhbmQgTWV0YWJv

bGlzbSwgTmFnb3lhIENpdHkgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBT

Y2llbmNlcywgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuOyBEZXBhcnRtZW50IG9mIEdhc3Ryb2Vu

dGVyb2xvZ3ksIEFpY2hpIE1lZGljYWwgVW5pdmVyc2l0eSwgTmFnYWt1dGUsIEphcGFuLiBKb2gs

VGFrYXNoaS4gRGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRlcm9sb2d5IGFuZCBNZXRhYm9saXNtLCBO

YWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2Vz

LCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW4uIEthbWl5YSxUYWtlc2hpLiBEZXBhcnRtZW50IG9m

IEdhc3Ryb2VudGVyb2xvZ3kgYW5kIE1ldGFib2xpc20sIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkg

R3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBK

YXBhbi4gQ2hlbmcsSmluZ2xlaS4gRGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBOYWdveWEg

Q2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1

aG8ta3UsIE5hZ295YSwgSmFwYW4uIE9nYXdhLEt1bWlrby4gRGVwYXJ0bWVudCBvZiBFeHBlcmlt

ZW50YWwgUGF0aG9sb2d5IGFuZCBUdW1vciBCaW9sb2d5LCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5

IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwg

SmFwYW47IERpdmlzaW9uIG9mIFBhdGhvbG9neSwgTmF0aW9uYWwgSW5zdGl0dXRlIG9mIEhlYWx0

aCBTY2llbmNlcywgU2V0YWdheWEta3UsIFRva3lvLCBKYXBhbi4gU2hpcmFpLFRvbW95dWtpLiBE

ZXBhcnRtZW50IG9mIEV4cGVyaW1lbnRhbCBQYXRob2xvZ3kgYW5kIFR1bW9yIEJpb2xvZ3ksIE5h

Z295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5jZXMs

IE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgTmFnb3lhIENpdHkgUmVoYWJpbGl0YXRpb24gQ2Vu

dGVyLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW4uIEltYWVkYSxOYWhvbWkuIERlcGFydG1lbnQg

b2YgUHVibGljIEhlYWx0aCwgTmFnb3lhIENpdHkgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wg

b2YgTWVkaWNhbCBTY2llbmNlcywgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuOyBEZXBhcnRtZW50

IG9mIEZvb2QgU2NpZW5jZSBhbmQgTnV0cml0aW9uLCBOYWdveWEgV29tZW4mYXBvcztzIFVuaXZl

cnNpdHksIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gR290byxDaGloby4gRGVwYXJ0bWVudCBv

ZiBQdWJsaWMgSGVhbHRoLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBv

ZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IERlcGFydG1lbnQg

b2YgSGVhbHRoIGFuZCBOdXRyaXRpb24sIE5hZ295YSBCdW5yaSBVbml2ZXJzaXR5LCBJbmF6YXdh

LCBKYXBhbi4gVG9rdWRvbWUsWXVrby4gRGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBOYWdv

eWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBN

aXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IFNjaG9vbCBvZiBOdXRyaXRpb25hbCBTY2llbmNlcywg

TmFnb3lhIFVuaXZlcnNpdHkgb2YgQXJ0cyBhbmQgU2NpZW5jZXMsIE5pc3NoaW4sIEphcGFuLiBJ

Y2hpa2F3YSxIaXJvbWl0c3UuIERlcGFydG1lbnQgb2YgUHVibGljIEhlYWx0aCwgTmFnb3lhIENp

dHkgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBTY2llbmNlcywgTWl6dWhv

LWt1LCBOYWdveWEsIEphcGFuLiBPa3V5YW1hLEhhcnVtaS4gSW5zdGl0dXRlIGZvciBDb25zdW1l

ciBTY2llbmNlIGFuZCBIdW1hbiBMaWZlLCBLaW5qbyBHYWt1aW4gVW5pdmVyc2l0eSwgTW9yaXlh

bWEta3UsIE5hZ295YSwgSmFwYW48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EaWV0YXJ5

IG4tMy9sb25nLWNoYWluIG4tMyBwb2x5dW5zYXR1cmF0ZWQgZmF0dHkgYWNpZHMgZm9yIHByZXZl

bnRpb24gb2Ygc3BvcmFkaWMgY29sb3JlY3RhbCB0dW1vcnM6IGEgcmFuZG9taXplZCBjb250cm9s

bGVkIHRyaWFsIGluIHBvbHlwZWN0b21pemVkIHBhcnRpY2lwYW50czwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5Qcm9zdGFnbGFuZGlucyBMZXVrb3RyaWVuZXMgJmFtcDsgRXNzZW50aWFsIEZhdHR5

IEFjaWRzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Qcm9zdGFnbGFuZGlucyBMZXVrb3Qg

RXNzZW50IEZhdHR5IEFjaWRzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+UHJvc3RhZ2xhbmRpbnMgTGV1a290cmllbmVzICZhbXA7IEVzc2VudGlhbCBGYXR0eSBB

Y2lkczwvZnVsbC10aXRsZT48YWJici0xPlByb3N0YWdsYW5kaW5zIExldWtvdCBFc3NlbnQgRmF0

dHkgQWNpZHM8L2FiYnItMT48YWJici0yPlByb3NhZ2xhbmRpbnMgTGV1a290cmllbmVzIGFuZCBF

c3NlbnRpYWwgRmF0dHkgQWNpZHM8L2FiYnItMj48YWJici0zPlByb3N0YWdsYW5kaW5zLCBMZXVr

b3RyaWVuZXMgYW5kIEVzc2VudGlhbCBGYXR0eSBBY2lkczwvYWJici0zPjwvcGVyaW9kaWNhbD48

YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UHJvc3RhZ2xhbmRpbnMgTGV1a290cmllbmVzICZh

bXA7IEVzc2VudGlhbCBGYXR0eSBBY2lkczwvZnVsbC10aXRsZT48YWJici0xPlByb3N0YWdsYW5k

aW5zIExldWtvdCBFc3NlbnQgRmF0dHkgQWNpZHM8L2FiYnItMT48YWJici0yPlByb3NhZ2xhbmRp

bnMgTGV1a290cmllbmVzIGFuZCBFc3NlbnRpYWwgRmF0dHkgQWNpZHM8L2FiYnItMj48YWJici0z

PlByb3N0YWdsYW5kaW5zLCBMZXVrb3RyaWVuZXMgYW5kIEVzc2VudGlhbCBGYXR0eSBBY2lkczwv

YWJici0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEtMTE8L3BhZ2VzPjx2b2x1bWU+OTQ8L3Zv

bHVtZT48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBDYXNlLUNvbnRyb2wgU3R1ZGllcyBD

b2xvcmVjdGFsIE5lb3BsYXNtcy9ibCBbQmxvb2RdICpDb2xvcmVjdGFsIE5lb3BsYXNtcy9kdCBb

RHJ1ZyBUaGVyYXB5XSAqQ29sb3JlY3RhbCBOZW9wbGFzbXMvcGMgW1ByZXZlbnRpb24gJmFtcDsg

Q29udHJvbF0gQ29sb3JlY3RhbCBOZW9wbGFzbXMvc3UgW1N1cmdlcnldICpEaWV0YXJ5IEZhdHMs

VW5zYXR1cmF0ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRDwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE1PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTUzMi0yODIz

PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnBsZWZhLjIwMTQu

MDkuMDAxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24t

VS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZh

bXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNTQ1MTU1Nmh0dHA6Ly9zZngudWNs

LmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjI1NDUxNTU2JmFt

cDtpZD1kb2k6MTAuMTAxNiUyRmoucGxlZmEuMjAxNC4wOS4wMDEmYW1wO2lzc249MDk1Mi0zMjc4

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTk0JmFtcDtpc3N1ZT0mYW1wO3NwYWdlPTEmYW1wO3BhZ2Vz

PTEtMTEmYW1wO2RhdGU9MjAxNSZhbXA7dGl0bGU9UHJvc3RhZ2xhbmRpbnMrTGV1a290cmllbmVz

KyUyNitFc3NlbnRpYWwrRmF0dHkrQWNpZHMmYW1wO2F0aXRsZT1EaWV0YXJ5K24tMyUyRmxvbmct

Y2hhaW4rbi0zK3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkcytmb3IrcHJldmVudGlvbitvZitz

cG9yYWRpYytjb2xvcmVjdGFsK3R1bW9ycyUzQSthK3JhbmRvbWl6ZWQrY29udHJvbGxlZCt0cmlh

bCtpbitwb2x5cGVjdG9taXplZCtwYXJ0aWNpcGFudHMuJmFtcDthdWxhc3Q9VG9rdWRvbWU8L3Vy

bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RWlu

dmlrPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVjTnVtPjQzOTM8L1JlY051bT48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQzOTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDIxMTgyMyI+NDM5Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

RWludmlrLCBHLjwvYXV0aG9yPjxhdXRob3I+RWtlYmVyZywgTy48L2F1dGhvcj48YXV0aG9yPkxh

dmlrLCBKLiBHLjwvYXV0aG9yPjxhdXRob3I+RWxsaW5nc2VuLCBJLjwvYXV0aG9yPjxhdXRob3I+

S2xlbXNkYWwsIFQuIE8uPC9hdXRob3I+PGF1dGhvcj5IamVya2lubiwgRS4gTS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5FaW52aWssR3VubmFyLiBEaXZp

c2lvbiBvZiBNZWRpY2luZSwgQWtlcnNodXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgTG9yZW5za29n

LCBOb3J3YXk7IERlcGFydG1lbnQgb2YgQmVoYXZpb3VyYWwgU2NpZW5jZSwgVW5pdmVyc2l0eSBv

ZiBPc2xvLCBPc2xvLCBOb3J3YXkuIGd1bm5hci5laW52aWtAbWVkaXNpbi51aW8ubm88L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgaW5mbHVlbmNlIG9mIGxvbmctdGVybSBhd2FyZW5l

c3Mgb2YgaHlwZXJsaXBpZGVtaWEgYW5kIG9mIDMgeWVhcnMgb2YgZGlldGFyeSBjb3Vuc2VsaW5n

IG9uIGRlcHJlc3Npb24sIGFueGlldHksIGFuZCBxdWFsaXR5IG9mIGxpZmU8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Sm91cm5hbCBvZiBQc3ljaG9zb21hdGljIFJlc2VhcmNoPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5KIFBzeWNob3NvbSBSZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNob3NvbWF0aWMgUmVzZWFyY2g8L2Z1

bGwtdGl0bGU+PGFiYnItMT5KIFBzeWNob3NvbSBSZXM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgUHN5Y2hvc29tYXRpYyBSZXNlYXJj

aDwvZnVsbC10aXRsZT48YWJici0xPkogUHN5Y2hvc29tIFJlczwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjU2Ny01NzI8L3BhZ2VzPjx2b2x1bWU+Njg8L3ZvbHVtZT48bnVtYmVyPjY8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkdWx0ICpBbnhpZXR5IERpc29yZGVycy9kaSBbRGlhZ25vc2lzXSBB

bnhpZXR5IERpc29yZGVycy9weCBbUHN5Y2hvbG9neV0gQXRoZXJvc2NsZXJvc2lzL2RoIFtEaWV0

IFRoZXJhcHldIEF0aGVyb3NjbGVyb3Npcy9weCBbUHN5Y2hvbG9neV0gQXR0aXR1ZGUgdG8gSGVh

bHRoICpBd2FyZW5lc3MgKkRlcHJlc3NpdmUgRGlzb3JkZXIvZGkgW0RpYWdub3Npc10gRGVwcmVz

c2l2ZSBEaXNvcmRlci9weCBbUHN5Y2hvbG9neV0gRGlldCxGYXQtUmU8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE4NzktMTM2MDwvaXNi

bj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qcHN5Y2hvcmVzLjIwMDku

MTEuMDA0O0NvbXBhcmF0aXZlIFN0dWR5IE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29u

dHJvbGxlZCBUcmlhbDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8v

b3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1w

O1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA0ODgyNzRodHRwOi8vc2Z4LnVjbC5h

Yy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMDQ4ODI3NCZhbXA7

aWQ9ZG9pOjEwLjEwMTYlMkZqLmpwc3ljaG9yZXMuMjAwOS4xMS4wMDQmYW1wO2lzc249MDAyMi0z

OTk5JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTY4JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT01NjcmYW1w

O3BhZ2VzPTU2Ny03MiZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1Kb3VybmFsK29mK1BzeWNob3Nv

bWF0aWMrUmVzZWFyY2gmYW1wO2F0aXRsZT1UaGUraW5mbHVlbmNlK29mK2xvbmctdGVybSthd2Fy

ZW5lc3Mrb2YraHlwZXJsaXBpZGVtaWErYW5kK29mKzMreWVhcnMrb2YrZGlldGFyeStjb3Vuc2Vs

aW5nK29uK2RlcHJlc3Npb24lMkMrYW54aWV0eSUyQythbmQrcXVhbGl0eStvZitsaWZlLiZhbXA7

YXVsYXN0PUVpbnZpazwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+

PENpdGU+PEF1dGhvcj5TYW55YWw8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MTQx

MzU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE0MTM1PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRm

ZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTczMjQiPjE0MTM1PC9rZXk+PC9mb3JlaWduLWtleXM+

PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv

cnM+PGF1dGhvcnM+PGF1dGhvcj5TYW55YWwsIEEuIEouPC9hdXRob3I+PGF1dGhvcj5BYmRlbG1h

bGVrLCBNLiBGLjwvYXV0aG9yPjxhdXRob3I+U3V6dWtpLCBBLjwvYXV0aG9yPjxhdXRob3I+Q3Vt

bWluZ3MsIE8uIFcuPC9hdXRob3I+PGF1dGhvcj5DaG9qa2llciwgTS48L2F1dGhvcj48YXV0aG9y

Pkdyb3VwLCBFcGU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5TYW55YWwsQXJ1biBKLiBEaXZpc2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5LCBIZXBhdG9sb2d5

IGFuZCBOdXRyaXRpb24sIERlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIFZpcmdpbmlh

IENvbW1vbndlYWx0aCBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgUmljaG1vbmQsIFZp

cmdpbmlhLiBFbGVjdHJvbmljIGFkZHJlc3M6IGFzYW55YWxAbWN2aC12Y3UuZWR1LiBBYmRlbG1h

bGVrLE1hbmFsIEYuIERpdmlzaW9uIG9mIEdhc3Ryb2VudGVyb2xvZ3kgYW5kIEhlcGF0b2xvZ3ks

IER1a2UgVW5pdmVyc2l0eSwgRHVyaGFtLCBOb3J0aCBDYXJvbGluYS4gU3V6dWtpLEF5YWtvLiBE

aXZpc2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5LCBVbml2ZXJzaXR5IG9mIEFya2Fuc2FzIGZvciBN

ZWRpY2FsIFNjaWVuY2VzLCBMaXR0bGUgUm9jaywgQXJrYW5zYXM7IERpdmlzaW9uIG9mIEdhc3Ry

b2VudGVyb2xvZ3ksIENlbnRyYWwgQXJrYW5zYXMgVmV0ZXJhbnMgSGVhbHRoY2FyZSBTeXN0ZW0s

IExpdHRsZSBSb2NrLCBBcmthbnNhcy4gQ3VtbWluZ3MsT3NjYXIgVy4gRGVwYXJ0bWVudCBvZiBQ

YXRob2xvZ3ksIEluZGlhbmEgVW5pdmVyc2l0eSwgQmxvb21pbmd0b24sIEluZGlhbmEuIENob2pr

aWVyLE1hcmlvLiBEaXZpc2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5IGFuZCBIZXBhdG9sb2d5LCBE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEs

IFNhbiBEaWVnbywgU2FuIERpZWdvLCBDYWxpZm9ybmlhPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+Tm8gc2lnbmlmaWNhbnQgZWZmZWN0cyBvZiBldGh5bC1laWNvc2FwZW50YW5vaWMgYWNp

ZCBvbiBoaXN0b2xvZ2ljIGZlYXR1cmVzIG9mIG5vbmFsY29ob2xpYyBzdGVhdG9oZXBhdGl0aXMg

aW4gYSBwaGFzZSAyIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkdhc3Ryb2VudGVyb2xv

Z3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkdhc3Ryb2VudGVyb2xvZ3k8L2FsdC10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5HYXN0cm9lbnRlcm9sb2d5PC9mdWxs

LXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+R2FzdHJvZW50

ZXJvbG9neTwvZnVsbC10aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4zNzctMzg0PC9wYWdl

cz48dm9sdW1lPjE0Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+

Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QmlvcHN5IERp

c2Vhc2UgUHJvZ3Jlc3Npb24gRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvc2FwZW50YWVub2ljIEFj

aWQvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkVpY29zYXBlbnRhZW5vaWMgQWNpZC9hYSBbQW5hbG9n

cyAmYW1wOyBEZXJpdmF0aXZlc10gRWljb3NhcGVudGFlbm9pYyBBY2lkL3R1IFtUaGVyYXBldXRp

YyBVc2VdIEZhdHR5IExpdmVyL2NvIFtDb21wbGljYXRpb25zXSAqRmF0dHkgTGl2ZXIvZHQgW0Ry

dWcgVGhlcmFweV0gRmF0dHkgTGk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAx

NDwveWVhcj48L2RhdGVzPjxpc2JuPjE1MjgtMDAxMjwvaXNibj48d29yay10eXBlPmh0dHA6Ly9k

eC5kb2kub3JnLzEwLjEwNTMvai5nYXN0cm8uMjAxNC4wNC4wNDY7Q2xpbmljYWwgVHJpYWwsIFBo

YXNlIElJIE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNl

YXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7

Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNDgx

ODc2NGh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtp

ZD1wbWlkOjI0ODE4NzY0JmFtcDtpZD1kb2k6MTAuMTA1MyUyRmouZ2FzdHJvLjIwMTQuMDQuMDQ2

JmFtcDtpc3NuPTAwMTYtNTA4NSZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xNDcmYW1wO2lzc3VlPTIm

YW1wO3NwYWdlPTM3NyZhbXA7cGFnZXM9Mzc3LTg0LmUxJmFtcDtkYXRlPTIwMTQmYW1wO3RpdGxl

PUdhc3Ryb2VudGVyb2xvZ3kmYW1wO2F0aXRsZT1ObytzaWduaWZpY2FudCtlZmZlY3RzK29mK2V0

aHlsLWVpY29zYXBlbnRhbm9pYythY2lkK29uK2hpc3RvbG9naWMrZmVhdHVyZXMrb2Yrbm9uYWxj

b2hvbGljK3N0ZWF0b2hlcGF0aXRpcytpbithK3BoYXNlKzIrdHJpYWwuJmFtcDthdWxhc3Q9U2Fu

eWFsPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkRhbnRoaWlyPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVjTnVtPjE4MzE0PC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4xODMxNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMzA0MDk3Ij4xODMxNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+RGFudGhpaXIsIFYuPC9hdXRob3I+PGF1dGhvcj5Ib3NraW5nLCBELjwvYXV0

aG9yPjxhdXRob3I+QnVybnMsIE4uIFIuPC9hdXRob3I+PGF1dGhvcj5XaWxzb24sIEMuPC9hdXRo

b3I+PGF1dGhvcj5OZXR0ZWxiZWNrLCBULjwvYXV0aG9yPjxhdXRob3I+Q2FsdmFyZXNpLCBFLjwv

YXV0aG9yPjxhdXRob3I+ZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

dGl0bGVzPjx0aXRsZT5Db2duaXRpdmUgcGVyZm9ybWFuY2UgaW4gb2xkZXIgYWR1bHRzIGlzIGlu

dmVyc2VseSBhc3NvY2lhdGVkIHdpdGggZmlzaCBjb25zdW1wdGlvbiBidXQgbm90IGVyeXRocm9j

eXRlIG1lbWJyYW5lIG4tMyBmYXR0eSBhY2lkczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaGUg

Sm91cm5hbCBvZiBudXRyaXRpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkog

TnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIGpvdXJuYWwgb2YgbnV0cml0aW9uPC9hYmJyLTI+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4zMTEtMzIwPC9wYWdlcz48dm9sdW1lPjE0NDwvdm9sdW1lPjxudW1i

ZXI+MzwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxz

PjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkZlcnJlaXJhPC9BdXRob3I+PFllYXI+MjAx

NTwvWWVhcj48UmVjTnVtPjQ3OTU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ3OTU8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNz

NWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxMjA2MSI+NDc5NTwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RmVycmVpcmEsIEouIEouPC9hdXRo

b3I+PGF1dGhvcj5Sb3NzZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5DcmF1ZnVyZCwgRC48L2F1dGhv

cj48YXV0aG9yPlNxdWl0aWVyaSwgRi48L2F1dGhvcj48YXV0aG9yPk1hbGxhcmQsIE4uPC9hdXRo

b3I+PGF1dGhvcj5MYW5kd2Vocm1leWVyLCBCLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkZlcnJlaXJhLEpvYXF1aW0gSi4gQ2xpbmljYWwgUGhhcm1hY29s

b2d5IFVuaXQsIEluc3RpdHV0byBkZSBNZWRpY2luYSBNb2xlY3VsYXIsIEZhY3VsdHkgb2YgTWVk

aWNpbmUsIFVuaXZlcnNpdHkgb2YgTGlzYm9uLCBQb3J0dWdhbC4gUm9zc2VyLEFubmUuIENhcmRp

ZmYgU2Nob29scyBvZiBNZWRpY2luZSBhbmQgQmlvc2NpZW5jZXMsIENhcmRpZmYgVW5pdmVyc2l0

eSwgVW5pdGVkIEtpbmdkb20uIENyYXVmdXJkLERhdmlkLiBVbml2ZXJzaXR5IG9mIE1hbmNoZXN0

ZXIsIE1hbmNoZXN0ZXIgQWNhZGVtaWMgSGVhbHRoIFNjaWVuY2VzIENlbnRlciBhbmQgQ2VudHJh

bCBNYW5jaGVzdGVyIFVuaXZlcnNpdHkgSG9zcGl0YWxzIE5IUyBGb3VuZGF0aW9uIFRydXN0LCBN

YW5jaGVzdGVyLCBVbml0ZWQgS2luZ2RvbS4gU3F1aXRpZXJpLEZlcmRpbmFuZG8uIElSQ1NTIE5l

dXJvbWVkLCBQb3p6aWxsaSwgSXRhbHkuIE1hbGxhcmQsTmljaG9sYXMuIEFtYXJpbiBQaGFybWEg

SW5jLiwgQmVkbWluc3RlciwgTmV3IEplcnNleSwgVVNBLiBMYW5kd2Vocm1leWVyLEJlcm5oYXJk

LiBVbml2ZXJzaXRhdHNrbGluaWsgVWxtLCBVbG0sIEdlcm1hbnk8L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5FdGh5bC1laWNvc2FwZW50YWVub2ljIGFjaWQgdHJlYXRtZW50IGluIEh1bnRp

bmd0b24mYXBvcztzIGRpc2Vhc2U6IEEgcGxhY2Viby1jb250cm9sbGVkIGNsaW5pY2FsIHRyaWFs

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk1vdmVtZW50IERpc29yZGVyczwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+TW92IERpc29yZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk1vdmVtZW50IGRpc29yZGVycyA6IG9mZmljaWFsIGpvdXJuYWwgb2YgdGhl

IE1vdmVtZW50IERpc29yZGVyIFNvY2lldHk8L2Z1bGwtdGl0bGU+PGFiYnItMT5Nb3YgRGlzb3Jk

PC9hYmJyLTE+PGFiYnItMj5Nb3ZlbWVudCBEaXNvcmRlcnM8L2FiYnItMj48L3BlcmlvZGljYWw+

PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk1vdmVtZW50IGRpc29yZGVycyA6IG9mZmljaWFs

IGpvdXJuYWwgb2YgdGhlIE1vdmVtZW50IERpc29yZGVyIFNvY2lldHk8L2Z1bGwtdGl0bGU+PGFi

YnItMT5Nb3YgRGlzb3JkPC9hYmJyLTE+PGFiYnItMj5Nb3ZlbWVudCBEaXNvcmRlcnM8L2FiYnIt

Mj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNDI2LTE0Mjk8L3BhZ2VzPjx2b2x1bWU+MzA8L3Zv

bHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVw

cmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdCBBZ2VkIERvdWJsZS1CbGluZCBN

ZXRob2QgRWljb3NhcGVudGFlbm9pYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3Nh

Z2VdICpFaWNvc2FwZW50YWVub2ljIEFjaWQvYWEgW0FuYWxvZ3MgJmFtcDsgRGVyaXZhdGl2ZXNd

IEVpY29zYXBlbnRhZW5vaWMgQWNpZC9wZCBbUGhhcm1hY29sb2d5XSBGZW1hbGUgSHVtYW5zICpI

dW50aW5ndG9uIERpc2Vhc2UvZHQgW0RydWcgVGhlcmFweV0gTWFsZSBNaWRkbGUgQWdlZCAqT3V0

Y29tZSBBc3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2Rh

dGVzPjxpc2JuPjE1MzEtODI1NzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEw

LjEwMDIvbWRzLjI2MzA4O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBU

cmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVy

bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/

VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFt

cDtBTj0yNjE3NTMzMmh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRs

aW5lJmFtcDtpZD1wbWlkOjI2MTc1MzMyJmFtcDtpZD1kb2k6MTAuMTAwMiUyRm1kcy4yNjMwOCZh

bXA7aXNzbj0wODg1LTMxODUmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzAmYW1wO2lzc3VlPTEwJmFt

cDtzcGFnZT0xNDI2JmFtcDtwYWdlcz0xNDI2LTkmYW1wO2RhdGU9MjAxNSZhbXA7dGl0bGU9TW92

ZW1lbnQrRGlzb3JkZXJzJmFtcDthdGl0bGU9RXRoeWwtZWljb3NhcGVudGFlbm9pYythY2lkK3Ry

ZWF0bWVudCtpbitIdW50aW5ndG9uJTI3cytkaXNlYXNlJTNBK0ErcGxhY2Viby1jb250cm9sbGVk

K2NsaW5pY2FsK3RyaWFsLiZhbXA7YXVsYXN0PUZlcnJlaXJhPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhhc2hpbW90bzwvQXV0aG9yPjxZ

ZWFyPjIwMTY8L1llYXI+PFJlY051bT4yMDIyMzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+

MjAyMjM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5

MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDM1NTUzNCI+

MjAyMjM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhhc2hpbW90bywg

TS48L2F1dGhvcj48YXV0aG9yPkthdG8sIFMuPC9hdXRob3I+PGF1dGhvcj5UYW5hYmUsIFkuPC9h

dXRob3I+PGF1dGhvcj5LYXRha3VyYSwgTS48L2F1dGhvcj48YXV0aG9yPk1hbXVuLCBBLiBBLjwv

YXV0aG9yPjxhdXRob3I+T2hubywgTS48L2F1dGhvcj48YXV0aG9yPmV0LCBhIGw8L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+QmVuZWZpY2lhbCBlZmZlY3Rz

IG9mIGRpZXRhcnkgZG9jb3NhaGV4YWVub2ljIGFjaWQgaW50ZXJ2ZW50aW9uIG9uIGNvZ25pdGl2

ZSBmdW5jdGlvbiBhbmQgbWVudGFsIGhlYWx0aCBvZiB0aGUgb2xkZXN0IGVsZGVybHkgaW4gSmFw

YW5lc2UgY2FyZSBmYWNpbGl0aWVzIGFuZCBudXJzaW5nIGhvbWVzPC90aXRsZT48c2Vjb25kYXJ5

LXRpdGxlPkdlcmlhdHJpY3MgJmFtcDsgR2Vyb250b2xvZ3kgSW50ZXJuYXRpb25hbDwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkdlcmlhdHJpY3MgYW5k

IEdlcm9udG9sb2d5IEludGVybmF0aW9uYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5HZXJpYXRyIEdl

cm9udG9sIEludDwvYWJici0xPjxhYmJyLTI+R2VyaWF0cmljcyAmYW1wOyBHZXJvbnRvbG9neSBJ

bnRlcm5hdGlvbmFsPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMzAtMzM3PC9wYWdlcz48

dm9sdW1lPjE3PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTY8L3ll

YXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SmFj

a3NvbjwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4yMDIyMDwvUmVjTnVtPjxyZWNv

cmQ+PHJlYy1udW1iZXI+MjAyMjA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFt

cD0iMTUzMDM1NTUzMiI+MjAyMjA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkphY2tzb24sIFAuIEEuPC9hdXRob3I+PGF1dGhvcj5Gb3JzdGVyLCBKLiBTLjwvYXV0aG9y

PjxhdXRob3I+QmVsbCwgSi4gRy48L2F1dGhvcj48YXV0aG9yPkRpY2ssIEouIFIuPC9hdXRob3I+

PGF1dGhvcj5Zb3VuZ2VyLCBJLjwvYXV0aG9yPjxhdXRob3I+S2VubmVkeSwgRC4gTy48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+REhBIFN1cHBsZW1lbnRh

dGlvbiBBbG9uZSBvciBpbiBDb21iaW5hdGlvbiB3aXRoIE90aGVyIE51dHJpZW50cyBEb2VzIG5v

dCBNb2R1bGF0ZSBDZXJlYnJhbCBIZW1vZHluYW1pY3Mgb3IgQ29nbml0aXZlIEZ1bmN0aW9uIGlu

IEhlYWx0aHkgT2xkZXIgQWR1bHRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk51dHJpZW50czwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk51dHJpZW50

czwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjg2LTg2PC9wYWdlcz48dm9sdW1lPjg8

L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+OTEyODwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTEyODwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNz

NGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjE0NDk0Ij45MTI4PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MZWUsIFMuIFAuPC9hdXRob3I+PGF1dGhvcj5EYXJ0

LCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+V2Fsa2VyLCBLLiBaLjwvYXV0aG9yPjxhdXRob3I+TyZh

cG9zO0RlYSwgSy48L2F1dGhvcj48YXV0aG9yPkNoaW4tRHVzdGluZywgSi4gUC48L2F1dGhvcj48

YXV0aG9yPlNraWx0b24sIE0uIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+TGVlLFNhYnJpbmEgUCBTLiBCYWtlciBJREkgSGVhcnQgYW5kIERpYWJldGVz

IEluc3RpdHV0ZSwgU3QgS2lsZGEgUm9hZCBDZW50cmFsLCBNZWxib3VybmUsIFZJQyA4MDA4LCBB

dXN0cmFsaWE8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5FZmZlY3Qgb2YgYWx0ZXJpbmcg

ZGlldGFyeSBuLTY6bi0zIFBVRkEgcmF0aW8gb24gY2FyZGlvdmFzY3VsYXIgcmlzayBtZWFzdXJl

cyBpbiBwYXRpZW50cyB0cmVhdGVkIHdpdGggc3RhdGluczogYSBwaWxvdCBzdHVkeTwvdGl0bGU+

PHNlY29uZGFyeS10aXRsZT5Ccml0aXNoIEpvdXJuYWwgb2YgTnV0cml0aW9uPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5CciBKIE51dHI8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5Ccml0aXNoIEpvdXJuYWwgb2YgTnV0cml0aW9uPC9mdWxsLXRpdGxlPjxh

YmJyLTE+QnIgSiBOdXRyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Ccml0aXNoIEpvdXJuYWwgb2YgTnV0cml0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+

QnIgSiBOdXRyPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTI4MC0xMjg1PC9wYWdl

cz48dm9sdW1lPjEwODwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+

Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQgQXBv

bGlwb3Byb3RlaW4gQS1JL2JsIFtCbG9vZF0gQXBvbGlwb3Byb3RlaW5zIEIvYmwgW0Jsb29kXSBD

LVJlYWN0aXZlIFByb3RlaW4vYW4gW0FuYWx5c2lzXSAqQ2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMv

ZXAgW0VwaWRlbWlvbG9neV0gQ2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXQgW0V0aW9sb2d5XSBD

aG9sZXN0ZXJvbCxMREwvYmwgW0Jsb29kXSBDb21iaW5lZCBNb2RhbGl0eSBUaGVyYXB5IENyb3Nz

LU92ZXIgU3R1ZGllcyBEaTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95

ZWFyPjwvZGF0ZXM+PGlzYm4+MTQ3NS0yNjYyPC9pc2JuPjx3b3JrLXR5cGU+Q2xpbmljYWwgVHJp

YWwgUmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIyMTgyNDgyaHR0cDovL3NmeC51Y2wuYWMu

dWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjIxODI0ODImYW1wO2lk

PWRvaTomYW1wO2lzc249MDAwNy0xMTQ1JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTEwOCZhbXA7aXNz

dWU9NyZhbXA7c3BhZ2U9MTI4MCZhbXA7cGFnZXM9MTI4MC01JmFtcDtkYXRlPTIwMTImYW1wO3Rp

dGxlPUJyaXRpc2grSm91cm5hbCtvZitOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2YrYWx0

ZXJpbmcrZGlldGFyeStuLTYlM0FuLTMrUFVGQStyYXRpbytvbitjYXJkaW92YXNjdWxhcityaXNr

K21lYXN1cmVzK2luK3BhdGllbnRzK3RyZWF0ZWQrd2l0aCtzdGF0aW5zJTNBK2ErcGlsb3Qrc3R1

ZHkuJmFtcDthdWxhc3Q9TGVlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPlZlbGxhczwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJlY051

bT4xNjYxNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTY2MTc8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRh

YXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxODc0MiI+MTY2MTc8L2tleT48L2ZvcmVpZ24t

a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy

aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlZlbGxhcywgQi48L2F1dGhvcj48YXV0aG9yPkNhcnJp

ZSwgSS48L2F1dGhvcj48YXV0aG9yPkd1eW9ubmV0LCBTLjwvYXV0aG9yPjxhdXRob3I+VG91Y2hv

biwgSi48L2F1dGhvcj48YXV0aG9yPkRhbnRvaW5lLCBULjwvYXV0aG9yPjxhdXRob3I+RGFydGln

dWVzLCBKLiBGLjwvYXV0aG9yPjxhdXRob3I+Q3VmaSwgTS4gTi48L2F1dGhvcj48YXV0aG9yPkJv

cmRlcywgUy48L2F1dGhvcj48YXV0aG9yPkdhc25pZXIsIFkuPC9hdXRob3I+PGF1dGhvcj5Sb2Jl

cnQsIFAuPC9hdXRob3I+PGF1dGhvcj5Cb3JpZXMsIEwuPC9hdXRob3I+PGF1dGhvcj5Sb3VhdWQs

IE8uPC9hdXRob3I+PGF1dGhvcj5EZXNjbGF1eCwgRi48L2F1dGhvcj48YXV0aG9yPlN1ZHJlcywg

Sy48L2F1dGhvcj48YXV0aG9yPkJvbm5lZm95LCBNLjwvYXV0aG9yPjxhdXRob3I+UGVzY2UsIEEu

PC9hdXRob3I+PGF1dGhvcj5Gb3VnZXJlLCBCLjwvYXV0aG9yPjxhdXRob3I+RGVscmlldSwgSi48

L2F1dGhvcj48YXV0aG9yPkZhaXNhbnQsIEMuPC9hdXRob3I+PGF1dGhvcj5MYWxhLCBGLjwvYXV0

aG9yPjxhdXRob3I+RHVwdXksIEMuPC9hdXRob3I+PGF1dGhvcj5DYW50ZXQsIEMuPC9hdXRob3I+

PGF1dGhvcj5Db2xleSwgTi48L2F1dGhvcj48YXV0aG9yPkJlbGxldmlsbGUsIFMuPC9hdXRob3I+

PGF1dGhvcj5XaWxsaXMsIFMuIEwuPC9hdXRob3I+PGF1dGhvcj5XZWluZXIsIE0uIFcuPC9hdXRo

b3I+PGF1dGhvcj5KZWFuIE91c3NldCwgUC48L2F1dGhvcj48YXV0aG9yPkFuZHJpZXUsIFMuPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+KFZlbGxhcykgSU5T

RVJNIFVNUiAxMDI3LCBUb3Vsb3VzZSwgRnJhbmNlIChWZWxsYXMsIEd1eW9ubmV0LCBDb2xleSkg

VW5pdmVyc2l0eSBvZiBUb3Vsb3VzZSBJSUksIFRvdWxvdXNlLCBGcmFuY2UgKFZlbGxhcywgTGFs

YSwgSmVhbiBPdXNzZXQpIENIVSBUb3Vsb3VzZSwgVG91bG91c2UsIEZyYW5jZSAoQ2FycmllLCBH

dXlvbm5ldCwgRm91Z2VyZSwgRmFpc2FudCwgRHVwdXksIENhbnRldCwgQW5kcmlldSkgVG91bG91

c2VGcmFuY2UgKEd1eW9ubmV0LCBEdXB1eSwgQ2FudGV0LCBDb2xleSkgSU5TRVJNIFVNUiAxMDI3

LCBGcmFuY2UgKFRvdWNob24pIENIVSBNb250cGVsbGllciwgTW9udHBlbGxpZXIsIEZyYW5jZSAo

RGFudG9pbmUpIENIVSBMaW1vZ2VzLCBMaW1vZ2VzLCBGcmFuY2UgKERhcnRpZ3VlcykgSU5TRVJN

IFU4OTcsIEJvcmRlYXV4LCBGcmFuY2UgKERhcnRpZ3VlcykgQm9yZGVhdXggVW5pdmVyc2l0eSwg

Qm9yZGVhdXgsIEZyYW5jZSAoRGFydGlndWVzKSBNZW1vcnkgY29uc3VsdGF0aW9uLCBDSFUgQm9y

ZGVhdXgsIEJvcmRlYXV4LCBGcmFuY2UgKERhcnRpZ3VlcykgQm9yZGVhdXggVW5pdmVyc2l0eSBI

b3NwaXRhbCwgQm9yZGVhdXgsIEZyYW5jZSAoQ3VmaSkgQ0ggQ2FzdHJlcywgQ2FzdHJlcywgRnJh

bmNlIChCb3JkZXMsIEdhc25pZXIpIENIIFRhcmJlcywgVGFyYmVzLCBGcmFuY2UgKFJvYmVydCkg

Q0hVIE5pY2UsIE5pY2UsIEZyYW5jZSAoQm9yaWVzKSBDSCBGb2l4LCBGb2l4LCBGcmFuY2UgKFJv

dWF1ZCkgSG9waXRhbCBHZW5lcmFsLCBEaWpvbiwgRnJhbmNlIChEZXNjbGF1eCkgQ0ggTGF2YXVy

LCBMYXZhdXIsIEZyYW5jZSAoU3VkcmVzKSBDSCBNb250YXViYW4sIE1vbnRhdWJhbiwgRnJhbmNl

IChCb25uZWZveSkgQ0hVIEx5b24gU1VELCBMeW9uLCBGcmFuY2UgKFBlc2NlKSBDSCBQcmluY2Vz

c2UgR3JhY2UsIE1vbmFjbywgTW9uYWNvIChEZWxyaWV1KSBJbnN0aXR1dGUgb2YgQWdpbmcsIFVu

aXZlcnNpdHkgSG9zcGl0YWwgVG91bG91c2UsIFRvdWxvdXNlLCBGcmFuY2UgKEJlbGxldmlsbGUp

IEluc3RpdHV0IFVuaXZlcnNpdGFpcmUgRGUgR2VyaWF0cmllIERlIE1vbnRyZWFsLCBNb250cmVh

bCwgUUMsIENhbmFkYSAoQmVsbGV2aWxsZSkgVW5pdmVyc2l0ZSBEZSBNb250cmVhbCwgTW9udHJl

YWwsIFFDLCBDYW5hZGEgKFdpbGxpcykgSW5kaWFuYSBVbml2ZXJzaXR5LCBJbmRpYW5hcG9saXMs

IElOLCBVbml0ZWQgU3RhdGVzIChXZWluZXIpIFVuaXZlcnNpdHkgb2YgQ2FsaWZvcm5pYSBTYW4g

RnJhbmNpc2NvLCBTYW4gRnJhbmNpc2NvLCBDQSwgVW5pdGVkIFN0YXRlcyAoQW5kcmlldSkgSU5T

RVJNIFVNUiAxMDI3LCBQYXVsIFNhYmF0aWVyIFVuaXZlcnNpdHksIFRvdWxvdXNlLCBGcmFuY2Ug

Qi4gVmVsbGFzLCBJTlNFUk0gVU1SIDEwMjcsIFRvdWxvdXNlLCBGcmFuY2UuIEUtbWFpbDogdmVs

bGFzLmJAY2h1LXRvdWxvdXNlLmZyPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW==

ADDIN EN.CITE.DATA QVBUIChtdWx0aS1kb21haW4gQWx6aGVpbWVyJmFwb3M7cyBwcmV2ZW50aW9uIHRyaWFsKTogUmVz

dWx0cyBhdCAzNiBtb250aHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QWx6aGVpbWVyJmFwb3M7

cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlhPC9mdWxsLXRpdGxlPjxhYmJy

LTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJici0yPkFsemhlaW1lciZhcG9z

O3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWltZXJzIGFuZCBEZW1lbnRpYTwv

YWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+MzMxPC9wYWdlcz48dm9sdW1lPjEpPC92b2x1bWU+

PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48

a2V5d29yZD5wcmV2ZW50aW9uIHN0dWR5IGh1bWFuIGNvZ25pdGlvbiBtZW1vcnkgc2FmZXR5IGRp

Z2l0IHN5bWJvbCBzdWJzdGl0dXRpb24gdGVzdCBjbGluaWNhbCB0cmlhbCBob3NwaXRhbCB0cmFp

bCBtYWtpbmcgdGVzdCBudXRyaXRpb24gcGh5c2ljYWwgYWN0aXZpdHkgb3V0cGF0aWVudCBhZ2Vk

IHN1cHBsZW1lbnRhdGlvbiBhZHVsdCBXZWNoc2xlciBhZHVsdCBpbnRlbGxpZ2VuY2Ugc2NhbGUg

TWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh

dGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNibj4xNTUyLTUyNjA8L2lzYm4+PHdvcmst

dHlwZT5Db25mZXJlbmNlIEFic3RyYWN0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48

dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1w

O05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1lbWVkMTMmYW1wO0FOPTcyMTI0NTcxaHR0

cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOmVtYmFzZSZhbXA7aWQ9cG1pZDom

YW1wO2lkPWRvaTomYW1wO2lzc249MTU1Mi01MjYwJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTExJmFt

cDtpc3N1ZT03K1NVUFBMLisxJmFtcDtzcGFnZT1QMzMxJmFtcDtwYWdlcz1QMzMxJmFtcDtkYXRl

PTIwMTUmYW1wO3RpdGxlPUFsemhlaW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9TUFQ

VCslMjhtdWx0aS1kb21haW4rQWx6aGVpbWVyJTI3cytwcmV2ZW50aW9uK3RyaWFsJTI5JTNBK1Jl

c3VsdHMrYXQrMzYrbW9udGhzJmFtcDthdWxhc3Q9VmVsbGFzPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlZhbiBEZSBSZXN0PC9BdXRob3I+

PFllYXI+MjAwODwvWWVhcj48UmVjTnVtPjE2NDUxPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJl

cj4xNjQ1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUy

ejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjE4NjQx

Ij4xNjQ1MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj

bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VmFuIERlIFJl

c3QsIE8uPC9hdXRob3I+PGF1dGhvcj5HZWxlaWpuc2UsIEouIE0uPC9hdXRob3I+PGF1dGhvcj5L

b2ssIEYuIEouPC9hdXRob3I+PGF1dGhvcj52YW4gU3RhdmVyZW4sIFcuIEEuPC9hdXRob3I+PGF1

dGhvcj5EdWxsZW1laWplciwgQy48L2F1dGhvcj48YXV0aG9yPk9sZGVyaWtrZXJ0LCBNLiBHLjwv

YXV0aG9yPjxhdXRob3I+QmVla21hbiwgQS4gVC48L2F1dGhvcj48YXV0aG9yPkRlIEdyb290LCBD

LiBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPnZhbiBk

ZSBSZXN0LE8uIFdhZ2VuaW5nZW4gVW5pdmVyc2l0eSwgRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0

aW9uLCBQLk8uIEJveCA4MTI5LCA2NzAwIEVWLCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMu

IG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZm

ZWN0IG9mIGZpc2ggb2lsIG9uIGNvZ25pdGl2ZSBwZXJmb3JtYW5jZSBpbiBvbGRlciBzdWJqZWN0

czogYSByYW5kb21pemVkLCBjb250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

Pk5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TmV1cm9sb2d5PC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cm9sb2d5PC9mdWxsLXRpdGxl

PjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cm9sb2d5PC9mdWxs

LXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQzMC00Mzg8L3BhZ2VzPjx2b2x1bWU+NzE8

L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9y

ZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQ2Fwc3VsZXMgKkNvZ25pdGlv

biAqQ29nbml0aW9uIERpc29yZGVycy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSBEaWV0

YXJ5IFN1cHBsZW1lbnRzIERvdWJsZS1CbGluZCBNZXRob2QgKkVpY29zYXBlbnRhZW5vaWMgQWNp

ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSAqRmF0dHkgQWNpZHMsVW5zYXR1cmF0

ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmVtYWxlICpGaXNoIE9pbHMvYWQg

W0FkbWluaXN0cmF0aW88L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwODwveWVh

cj48L2RhdGVzPjxpc2JuPjE1MjYtNjMyWDwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2ku

b3JnLzEwLjEyMTIvMDEud25sLjAwMDAzMjQyNjguNDUxMzguODY7UmFuZG9taXplZCBDb250cm9s

bGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2Vi

LmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1l

ZDUmYW1wO0FOPTE4Njc4ODI2aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklE

Om1lZGxpbmUmYW1wO2lkPXBtaWQ6MTg2Nzg4MjYmYW1wO2lkPWRvaToxMC4xMjEyJTJGMDEud25s

LjAwMDAzMjQyNjguNDUxMzguODYmYW1wO2lzc249MDAyOC0zODc4JmFtcDtpc2JuPSZhbXA7dm9s

dW1lPTcxJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT00MzAmYW1wO3BhZ2VzPTQzMC04JmFtcDtkYXRl

PTIwMDgmYW1wO3RpdGxlPU5ldXJvbG9neSZhbXA7YXRpdGxlPUVmZmVjdCtvZitmaXNoK29pbCtv

bitjb2duaXRpdmUrcGVyZm9ybWFuY2UraW4rb2xkZXIrc3ViamVjdHMlM0ErYStyYW5kb21pemVk

JTJDK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFuK2RlK1Jlc3Q8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+WXVya28tTWF1cm88

L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNOdW0+MTc3MjQ8L1JlY051bT48cmVjb3JkPjxy

ZWMtbnVtYmVyPjE3NzI0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAyMTk0MTgiPjE3NzI0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Z

dXJrby1NYXVybywgSy48L2F1dGhvcj48YXV0aG9yPk1jQ2FydGh5LCBELjwvYXV0aG9yPjxhdXRo

b3I+Um9tLCBELjwvYXV0aG9yPjxhdXRob3I+TmVsc29uLCBFLiBCLjwvYXV0aG9yPjxhdXRob3I+

UnlhbiwgQS4gUy48L2F1dGhvcj48YXV0aG9yPkJsYWNrd2VsbCwgQS48L2F1dGhvcj48YXV0aG9y

PlNhbGVtLCBOLiwgSnIuPC9hdXRob3I+PGF1dGhvcj5TdGVkbWFuLCBNLjwvYXV0aG9yPjxhdXRo

b3I+SW52ZXN0aWdhdG9ycywgTWlkYXM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5ZdXJrby1NYXVybyxLYXJpbi4gQ2xpbmljYWwgUmVzZWFyY2ggRGVwYXJ0

bWVudCwgTWFydGVrIEJpb3NjaWVuY2VzIENvcnBvcmF0aW9uLCBDb2x1bWJpYSwgTUQsIFVTQS4g

a3l1cmtvQG1hcnRlay5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5CZW5lZmljaWFs

IGVmZmVjdHMgb2YgZG9jb3NhaGV4YWVub2ljIGFjaWQgb24gY29nbml0aW9uIGluIGFnZS1yZWxh

dGVkIGNvZ25pdGl2ZSBkZWNsaW5lPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFsemhlaW1lciZh

cG9zO3MgJmFtcDsgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFsemhlaW1l

ciZhcG9zO3MgZGVtZW50PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvZnVsbC10aXRsZT48YWJici0xPkFs

emhlaW1lciZhcG9zO3MgZGVtZW50PC9hYmJyLTE+PGFiYnItMj5BbHpoZWltZXImYXBvcztzIGFu

ZCBEZW1lbnRpYTwvYWJici0yPjxhYmJyLTM+QWx6aGVpbWVycyBhbmQgRGVtZW50aWE8L2FiYnIt

Mz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFsemhlaW1lciZhcG9z

O3MgJmFtcDsgRGVtZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbHpoZWltZXImYXBvcztzIGRl

bWVudDwvYWJici0xPjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L2FiYnIt

Mj48YWJici0zPkFsemhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNh

bD48cGFnZXM+NDU2LTQ2NDwvcGFnZXM+PHZvbHVtZT42PC92b2x1bWU+PG51bWJlcj42PC9udW1i

ZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5BZ2VkICpBZ2luZy9kZSBbRHJ1ZyBFZmZlY3RzXSAqQWdpbmcvcHggW1BzeWNo

b2xvZ3ldICpDb2duaXRpb24gRGlzb3JkZXJzL2RpIFtEaWFnbm9zaXNdIENvZ25pdGlvbiBEaXNv

cmRlcnMvbWUgW01ldGFib2xpc21dICpDb2duaXRpb24gRGlzb3JkZXJzL3BjIFtQcmV2ZW50aW9u

ICZhbXA7IENvbnRyb2xdIERlbWVudGlhL2RpIFtEaWFnbm9zaXNdIERlbWVudGlhL2R0IFtEcnVn

IFRoZXJhcHldIERlbWVudGlhL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnQ8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE1NTItNTI3OTwv

aXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qYWx6LjIwMTAuMDEu

MDEzO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRjJmFtcDtBTj0yMDQzNDk2MWh0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDM0OTYxJmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouamFsei4yMDEwLjAxLjAxMyZhbXA7aXNzbj0xNTUyLTUyNjAmYW1w

O2lzYm49JmFtcDt2b2x1bWU9NiZhbXA7aXNzdWU9NiZhbXA7c3BhZ2U9NDU2JmFtcDtwYWdlcz00

NTYtNjQmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3cyslMjYrRGVtZW50aWEm

YW1wO2F0aXRsZT1CZW5lZmljaWFsK2VmZmVjdHMrb2YrZG9jb3NhaGV4YWVub2ljK2FjaWQrb24r

Y29nbml0aW9uK2luK2FnZS1yZWxhdGVkK2NvZ25pdGl2ZStkZWNsaW5lLiZhbXA7YXVsYXN0PVl1

cmtvLU1hdXJvPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0

ZT48QXV0aG9yPk1jR29ycnk8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxSZWNOdW0+MjAzMTE8

L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwMzExPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtl

eXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVm

czB0IiB0aW1lc3RhbXA9IjE1MzAzNTU1NzUiPjIwMzExPC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5NY0dvcnJ5LCBQLiBELjwvYXV0aG9yPjxhdXRob3I+TmVsc29uLCBC

LjwvYXV0aG9yPjxhdXRob3I+TWFya3VsZXYsIEMuPC9hdXRob3I+PGF1dGhvcj5ZdWVuLCBILiBQ

LjwvYXV0aG9yPjxhdXRob3I+U2Now6RmZXIsIE0uIFIuPC9hdXRob3I+PGF1dGhvcj5Nb3NzYWhl

YiwgTi48L2F1dGhvcj48YXV0aG9yPmV0LCBhIGw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli

dXRvcnM+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIM+JLTMgUG9seXVuc2F0dXJhdGVkIEZhdHR5

IEFjaWRzIGluIFlvdW5nIFBlb3BsZSBhdCBVbHRyYWhpZ2ggUmlzayBmb3IgUHN5Y2hvdGljIERp

c29yZGVyczogVGhlIE5FVVJBUFJPIFJhbmRvbWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+SkFNQSBQc3ljaGlhdHJ5PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SkFNQSBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjwvcGVy

aW9kaWNhbD48cGFnZXM+MTktMjc8L3BhZ2VzPjx2b2x1bWU+NzQ8L3ZvbHVtZT48bnVtYmVyPjE8

L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Ub3JraWxkc2VuPC9BdXRob3I+PFllYXI+MjAxMjwv

WWVhcj48UmVjTnVtPjE2MDk2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xNjA5NjwvcmVj

LW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1

ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjE4NDM2Ij4xNjA5Njwva2V5

PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt

dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VG9ya2lsZHNlbiwgTy48L2F1dGhv

cj48YXV0aG9yPldlcmdlbGFuZCwgUy48L2F1dGhvcj48YXV0aG9yPkJha2tlLCBTLjwvYXV0aG9y

PjxhdXRob3I+QmVpc2tlLCBBLiBHLjwvYXV0aG9yPjxhdXRob3I+QmplcnZlLCBLLiBTLjwvYXV0

aG9yPjxhdXRob3I+SG92ZGFsLCBILjwvYXV0aG9yPjxhdXRob3I+TWlkZ2FyZCwgUi48L2F1dGhv

cj48YXV0aG9yPkxpbGxlYXMsIEYuPC9hdXRob3I+PGF1dGhvcj5QZWRlcnNlbiwgVC48L2F1dGhv

cj48YXV0aG9yPkJqb3JuYXJhLCBCLjwvYXV0aG9yPjxhdXRob3I+RGFsZW5lLCBGLjwvYXV0aG9y

PjxhdXRob3I+S2xldmVsYW5kLCBHLjwvYXV0aG9yPjxhdXRob3I+U2NoZXBlbCwgSi48L2F1dGhv

cj48YXV0aG9yPk9sc2VuLCBJLiBDLjwvYXV0aG9yPjxhdXRob3I+TXlociwgSy4gTS48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Ub3JraWxkc2VuLE9pdmlu

ZC4gTm9yd2VnaWFuIE11bHRpcGxlIFNjbGVyb3NpcyBDb21wZXRlbmNlIENlbnRyZSwgRGVwYXJ0

bWVudCBvZiBOZXVyb2xvZ3ksIEhhdWtlbGFuZCBVbml2ZXJzaXR5IEhvc3BpdGFsLCBOb3J3YXku

IG9pdmluZC50b3JraWxkc2VuQGdtYWlsLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

Pm9tZWdhLTMgZmF0dHkgYWNpZCB0cmVhdG1lbnQgaW4gbXVsdGlwbGUgc2NsZXJvc2lzIChPRkFN

UyBTdHVkeSk6IGEgcmFuZG9taXplZCwgZG91YmxlLWJsaW5kLCBwbGFjZWJvLWNvbnRyb2xsZWQg

dHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QXJjaGl2ZXMgb2YgTmV1cm9sb2d5PC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5BcmNoIE5ldXJvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvZnVsbC10aXRsZT48

YWJici0xPkFyY2ggTmV1cm9sPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5BcmNoaXZlcyBvZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNo

IE5ldXJvbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwNDQtMTA1MTwvcGFnZXM+

PHZvbHVtZT42OTwvdm9sdW1lPjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9U

IElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQgRGlldGFy

eSBTdXBwbGVtZW50cyBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcgVGhlcmFweSxDb21iaW5hdGlv

biAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBG

ZW1hbGUgSHVtYW5zIEludGVyZmVyb24gYmV0YS0xYSBJbnRlcmZlcm9uLWJldGEvYWQgW0FkbWlu

aXN0cmF0aW9uICZhbXA7IERvc2FnZV0gTWFnbmV0aWMgUmVzb25hbmNlIEltYWdpbmcvdGQgW1Ry

ZW5kc10gTWFsZSBNaWRkbGUgQWdlPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw

MTI8L3llYXI+PC9kYXRlcz48aXNibj4xNTM4LTM2ODc8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8v

ZHguZG9pLm9yZy8xMC4xMDAxL2FyY2huZXVyb2wuMjAxMi4yODM7TXVsdGljZW50ZXIgU3R1ZHkg

UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRz

cC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdF

PWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIyNTA3ODg2aHR0cDovL3NmeC51Y2wuYWMudWsv

c2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjI1MDc4ODYmYW1wO2lkPWRv

aToxMC4xMDAxJTJGYXJjaG5ldXJvbC4yMDEyLjI4MyZhbXA7aXNzbj0wMDAzLTk5NDImYW1wO2lz

Ym49JmFtcDt2b2x1bWU9NjkmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTEwNDQmYW1wO3BhZ2VzPTEw

NDQtNTEmYW1wO2RhdGU9MjAxMiZhbXA7dGl0bGU9QXJjaGl2ZXMrb2YrTmV1cm9sb2d5JmFtcDth

dGl0bGU9b21lZ2EtMytmYXR0eSthY2lkK3RyZWF0bWVudCtpbittdWx0aXBsZStzY2xlcm9zaXMr

JTI4T0ZBTVMrU3R1ZHklMjklM0ErYStyYW5kb21pemVkJTJDK2RvdWJsZS1ibGluZCUyQytwbGFj

ZWJvLWNvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9VG9ya2lsZHNlbjwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5QYXdlbGN6eWs8L0F1

dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+MTI0MjA8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjEyNDIwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAy

MTYzNDEiPjEyNDIwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYXdl

bGN6eWssIFQuPC9hdXRob3I+PGF1dGhvcj5HcmFuY293LUdyYWJrYSwgTS48L2F1dGhvcj48YXV0

aG9yPktvdGxpY2thLUFudGN6YWssIE0uPC9hdXRob3I+PGF1dGhvcj5UcmFmYWxza2EsIEUuPC9h

dXRob3I+PGF1dGhvcj5QYXdlbGN6eWssIEEuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+UGF3ZWxjenlrLFRvbWFzei4gRGVwYXJ0bWVudCBvZiBBZmZlY3Rp

dmUgYW5kIFBzeWNob3RpYyBEaXNvcmRlcnMsIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBMb2R6LCB1

bC4gQ3plY2hvc2xvd2Fja2EgOC8xMCwgOTItMjE2IExvZHosIFBvbGFuZC4gRWxlY3Ryb25pYyBh

ZGRyZXNzOiB0b21hc3oucGF3ZWxjenlrQHVtZWQubG9kei5wbC4gR3JhbmNvdy1HcmFia2EsTWFy

dGEuIENlbnRyYWwgVGVhY2hpbmcgSG9zcGl0YWwsIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBMb2R6

LCB1bC4gUG9tb3Jza2EgMjUxLCA5Mi0yMTMgTG9keiwgUG9sYW5kLiBFbGVjdHJvbmljIGFkZHJl

c3M6IG1hcnRhZ3JhbmNvd0BnbWFpbC5jb20uIEtvdGxpY2thLUFudGN6YWssTWFnZGFsZW5hLiBE

ZXBhcnRtZW50IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywgTWVkaWNhbCBV

bml2ZXJzaXR5IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0yMTYgTG9keiwg

UG9sYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IG1hZ2RhbGVuYS5rb3RsaWNrYS1hbnRjemFrQHVt

ZWQubG9kei5wbC4gVHJhZmFsc2thLEVsemJpZXRhLiBEZXBhcnRtZW50IG9mIE51dHJpdGlvbiBI

eWdpZW5lIGFuZCBFcGlkZW1pb2xvZ3ksIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBMb2R6LCB1bC4g

SmFyYWN6YSA2MywgOTAtMjUxIExvZHosIFBvbGFuZC4gRWxlY3Ryb25pYyBhZGRyZXNzOiBlbHpi

aWV0YS50cmFmYWxza2FAdW1lZC5sb2R6LnBsLiBQYXdlbGN6eWssQWduaWVzemthLiBEZXBhcnRt

ZW50IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywgTWVkaWNhbCBVbml2ZXJz

aXR5IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0yMTYgTG9keiwgUG9sYW5k

LiBFbGVjdHJvbmljIGFkZHJlc3M6IGFnbmllc3prYS5wYXdlbGN6eWtAdW1lZC5sb2R6LnBsPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSByYW5kb21pemVkIGNvbnRyb2xsZWQgc3R1ZHkg

b2YgdGhlIGVmZmljYWN5IG9mIHNpeC1tb250aCBzdXBwbGVtZW50YXRpb24gd2l0aCBjb25jZW50

cmF0ZWQgZmlzaCBvaWwgcmljaCBpbiBvbWVnYS0zIHBvbHl1bnNhdHVyYXRlZCBmYXR0eSBhY2lk

cyBpbiBmaXJzdCBlcGlzb2RlIHNjaGl6b3BocmVuaWE8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+

Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0

bGU+SiBQc3ljaGlhdHIgUmVzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvZnVsbC10aXRsZT48YWJici0x

PkogUHN5Y2hpYXRyIFJlczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvZnVsbC10aXRsZT48YWJi

ci0xPkogUHN5Y2hpYXRyIFJlczwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjM0LTQ0

PC9wYWdlcz48dm9sdW1lPjczPC92b2x1bWU+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTg3

OS0xMzc5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmpwc3lj

aGlyZXMuMjAxNS4xMS4wMTM7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwv

d29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29t

L292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQm

YW1wO0Q9cHJlbSZhbXA7QU49MjY2Nzk3NjNodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/

c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyNjY3OTc2MyZhbXA7aWQ9ZG9pOjEwLjEwMTYl

MkZqLmpwc3ljaGlyZXMuMjAxNS4xMS4wMTMmYW1wO2lzc249MDAyMi0zOTU2JmFtcDtpc2JuPSZh

bXA7dm9sdW1lPTczJmFtcDtpc3N1ZT0xJmFtcDtzcGFnZT0zNCZhbXA7cGFnZXM9MzQtNDQmYW1w

O2RhdGU9MjAxNiZhbXA7dGl0bGU9Sm91cm5hbCtvZitQc3ljaGlhdHJpYytSZXNlYXJjaCZhbXA7

YXRpdGxlPUErcmFuZG9taXplZCtjb250cm9sbGVkK3N0dWR5K29mK3RoZStlZmZpY2FjeStvZitz

aXgtbW9udGgrc3VwcGxlbWVudGF0aW9uK3dpdGgrY29uY2VudHJhdGVkK2Zpc2grb2lsK3JpY2gr

aW4rb21lZ2EtMytwb2x5dW5zYXR1cmF0ZWQrZmF0dHkrYWNpZHMraW4rZmlyc3QrZXBpc29kZStz

Y2hpem9waHJlbmlhLiZhbXA7YXVsYXN0PVBhd2VsY3p5azwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5GcmV1bmQtTGV2aTwvQXV0aG9yPjxZ

ZWFyPjIwMDg8L1llYXI+PFJlY051bT41MDk3PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41

MDk3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBh

dzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTIyMjkiPjUw

OTc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkZyZXVuZC1MZXZpLCBZ

LjwvYXV0aG9yPjxhdXRob3I+QmFzdW4sIEguPC9hdXRob3I+PGF1dGhvcj5DZWRlcmhvbG0sIFQu

PC9hdXRob3I+PGF1dGhvcj5GYXhlbi1JcnZpbmcsIEcuPC9hdXRob3I+PGF1dGhvcj5HYXJsaW5k

LCBBLjwvYXV0aG9yPjxhdXRob3I+R3J1dCwgTS48L2F1dGhvcj48YXV0aG9yPlZlZGluLCBJLjwv

YXV0aG9yPjxhdXRob3I+UGFsbWJsYWQsIEouPC9hdXRob3I+PGF1dGhvcj5XYWhsdW5kLCBMLiBP

LjwvYXV0aG9yPjxhdXRob3I+RXJpa3Nkb3R0ZXItSm9uaGFnZW4sIE0uPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RnJldW5kLUxldmksWXZvbm5lLiBEZXBh

cnRtZW50IG9mIE5WUywgU2VjdGlvbiBvZiBDbGluaWNhbCBHZXJpYXRyaWNzLCBLYXJvbGluc2th

IEluc3RpdHV0ZXQgYXQgS2Fyb2xpbnNrYSBVbml2ZXJzaXR5IEhvc3BpdGFsIEh1ZGRpbmdlLCBT

dG9ja2hvbG0sIFN3ZWRlbi4gWXZvbm5lLkZyZXVuZC1MZXZpQGtpLnNlPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+T21lZ2EtMyBzdXBwbGVtZW50YXRpb24gaW4gbWlsZCB0byBtb2RlcmF0

ZSBBbHpoZWltZXImYXBvcztzIGRpc2Vhc2U6IGVmZmVjdHMgb24gbmV1cm9wc3ljaGlhdHJpYyBz

eW1wdG9tczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnRlcm5hdGlvbmFsIEpvdXJuYWwgb2Yg

R2VyaWF0cmljIFBzeWNoaWF0cnk8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkludCBKIEdl

cmlhdHIgUHN5Y2hpYXRyeTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp

dGxlPkludGVybmF0aW9uYWwgSm91cm5hbCBvZiBHZXJpYXRyaWMgUHN5Y2hpYXRyeTwvZnVsbC10

aXRsZT48YWJici0xPkludCBKIEdlcmlhdHIgUHN5Y2hpYXRyeTwvYWJici0xPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIEdl

cmlhdHJpYyBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50IEogR2VyaWF0ciBQc3lj

aGlhdHJ5PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTYxLTE2OTwvcGFnZXM+PHZv

bHVtZT4yMzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElO

IEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBvZiBE

YWlseSBMaXZpbmcgQWdlZCAqQWx6aGVpbWVyIERpc2Vhc2UvZHQgW0RydWcgVGhlcmFweV0gQWx6

aGVpbWVyIERpc2Vhc2UvZ2UgW0dlbmV0aWNzXSBBbHpoZWltZXIgRGlzZWFzZS9weCBbUHN5Y2hv

bG9neV0gQW5hbHlzaXMgb2YgVmFyaWFuY2UgQXBvbGlwb3Byb3RlaW5zIEUvZ2UgW0dlbmV0aWNz

XSAqQ2hvbGluZXN0ZXJhc2UgSW5oaWJpdG9ycy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEZXByZXNz

aW9uL2R0IFtEcjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwv

ZGF0ZXM+PGlzYm4+MDg4NS02MjMwPC9pc2JuPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9s

bGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlw

ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2Vi

LmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1l

ZDUmYW1wO0FOPTE3NTgyMjI1aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklE

Om1lZGxpbmUmYW1wO2lkPXBtaWQ6MTc1ODIyMjUmYW1wO2lkPWRvaTomYW1wO2lzc249MDg4NS02

MjMwJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTIzJmFtcDtpc3N1ZT0yJmFtcDtzcGFnZT0xNjEmYW1w

O3BhZ2VzPTE2MS05JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPUludGVybmF0aW9uYWwrSm91cm5h

bCtvZitHZXJpYXRyaWMrUHN5Y2hpYXRyeSZhbXA7YXRpdGxlPU9tZWdhLTMrc3VwcGxlbWVudGF0

aW9uK2luK21pbGQrdG8rbW9kZXJhdGUrQWx6aGVpbWVyJTI3cytkaXNlYXNlJTNBK2VmZmVjdHMr

b24rbmV1cm9wc3ljaGlhdHJpYytzeW1wdG9tcy4mYW1wO2F1bGFzdD1GcmV1bmQtTGV2aTwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SYXVj

aDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4xMzIwMzwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTMyMDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDIxNjc5NyI+MTMyMDM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlJhdWNoLCBCLjwvYXV0aG9yPjxhdXRob3I+U2NoaWVsZSwgUi48L2F1dGhvcj48YXV0aG9yPlNj

aG5laWRlciwgUy48L2F1dGhvcj48YXV0aG9yPkRpbGxlciwgRi48L2F1dGhvcj48YXV0aG9yPlZp

Y3RvciwgTi48L2F1dGhvcj48YXV0aG9yPkdvaGxrZSwgSC48L2F1dGhvcj48YXV0aG9yPkdvdHR3

aWssIE0uPC9hdXRob3I+PGF1dGhvcj5TdGVpbmJlY2ssIEcuPC9hdXRob3I+PGF1dGhvcj5EZWwg

Q2FzdGlsbG8sIFUuPC9hdXRob3I+PGF1dGhvcj5TYWNrLCBSLjwvYXV0aG9yPjxhdXRob3I+V29y

dGgsIEguPC9hdXRob3I+PGF1dGhvcj5LYXR1cywgSC48L2F1dGhvcj48YXV0aG9yPlNwaXR6ZXIs

IFcuPC9hdXRob3I+PGF1dGhvcj5TYWJpbiwgRy48L2F1dGhvcj48YXV0aG9yPlNlbmdlcywgSi48

L2F1dGhvcj48YXV0aG9yPkdyb3VwLCBPbWVnYSBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlJhdWNoLEJlcm5oYXJkLiBJbnN0aXR1dCBmdXIgSGVy

emluZmFya3Rmb3JzY2h1bmcgTHVkd2lnc2hhZmVuYW4gZGVyIFVuaXZlcnNpdGF0IEhlaWRlbGJl

cmcsIEdlcm1hbnkuIHJhdWNoQHphci1rYXJkaW8tbHVkd2lnc2hhZmVuLmRlPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+T01FR0EsIGEgcmFuZG9taXplZCwgcGxhY2Viby1jb250cm9sbGVk

IHRyaWFsIHRvIHRlc3QgdGhlIGVmZmVjdCBvZiBoaWdobHkgcHVyaWZpZWQgb21lZ2EtMyBmYXR0

eSBhY2lkcyBvbiB0b3Agb2YgbW9kZXJuIGd1aWRlbGluZS1hZGp1c3RlZCB0aGVyYXB5IGFmdGVy

IG15b2NhcmRpYWwgaW5mYXJjdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DaXJjdWxhdGlv

bjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2lyY3VsYXRpb248L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10aXRsZT48L3Bl

cmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNpcmN1bGF0aW9uPC9mdWxsLXRp

dGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIxNTItMjE1OTwvcGFnZXM+PHZvbHVtZT4xMjI8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIENvbWJpbmVkIE1vZGFsaXR5

IFRoZXJhcHkgRGVhdGgsU3VkZGVuLENhcmRpYWMvZXAgW0VwaWRlbWlvbG9neV0gKkRlYXRoLFN1

ZGRlbixDYXJkaWFjL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdICpGYXR0eSBBY2lkcyxP

bWVnYS0zL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdIEZhdHR5IEFjaWRzLE9tZWdh

LTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEZvb2QgSGFi

aXRzIEh1bTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUyNC00NTM5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTE2MS9DSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6

ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0

PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4

dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTA2MDA3MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2Nh

bD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMDYwMDcxJmFtcDtpZD1kb2k6MTAuMTE2

MSUyRkNJUkNVTEFUSU9OQUhBLjExMC45NDg1NjImYW1wO2lzc249MDAwOS03MzIyJmFtcDtpc2Ju

PSZhbXA7dm9sdW1lPTEyMiZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIxNTImYW1wO3BhZ2VzPTIx

NTItOSZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1DaXJjdWxhdGlvbiZhbXA7YXRpdGxlPU9NRUdB

JTJDK2ErcmFuZG9taXplZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwrdG8rdGVzdCt0aGUr

ZWZmZWN0K29mK2hpZ2hseStwdXJpZmllZCtvbWVnYS0zK2ZhdHR5K2FjaWRzK29uK3RvcCtvZitt

b2Rlcm4rZ3VpZGVsaW5lLWFkanVzdGVkK3RoZXJhcHkrYWZ0ZXIrbXlvY2FyZGlhbCtpbmZhcmN0

aW9uLiZhbXA7YXVsYXN0PVJhdWNoPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkRhbmdvdXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MzUwNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzUwNzwvcmVjLW51bWJlcj48

Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNz

NGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjExMzQ4Ij4zNTA3PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EYW5nb3VyLCBBLiBELjwvYXV0aG9yPjxhdXRob3I+

QWxsZW4sIEUuPC9hdXRob3I+PGF1dGhvcj5FbGJvdXJuZSwgRC48L2F1dGhvcj48YXV0aG9yPkZh

c2V5LCBOLjwvYXV0aG9yPjxhdXRob3I+RmxldGNoZXIsIEEuIEUuPC9hdXRob3I+PGF1dGhvcj5I

YXJkeSwgUC48L2F1dGhvcj48YXV0aG9yPkhvbGRlciwgRy4gRS48L2F1dGhvcj48YXV0aG9yPktu

aWdodCwgUi48L2F1dGhvcj48YXV0aG9yPkxldGxleSwgTC48L2F1dGhvcj48YXV0aG9yPlJpY2hh

cmRzLCBNLjwvYXV0aG9yPjxhdXRob3I+VWF1eSwgUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EYW5nb3VyLEFsYW4gRC4gTG9uZG9uIFNjaG9vbCBvZiBI

eWdpZW5lIGFuZCBUcm9waWNhbCBNZWRpY2luZSwgVW5pdGVkIEtpbmdkb20uIGFsYW4uZGFuZ291

ckBsc2h0bS5hYy51ayAmbHQ7YWxhbi5kYW5nb3VyQGxzaHRtLmFjLnVrJmd0OzwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdCBvZiAyLXkgbi0zIGxvbmctY2hhaW4gcG9seXVuc2F0

dXJhdGVkIGZhdHR5IGFjaWQgc3VwcGxlbWVudGF0aW9uIG9uIGNvZ25pdGl2ZSBmdW5jdGlvbiBp

biBvbGRlciBwZW9wbGU6IGEgcmFuZG9taXplZCwgZG91YmxlLWJsaW5kLCBjb250cm9sbGVkIHRy

aWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwg

TnV0cml0aW9uPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BbSBKIENsaW4gTnV0cjwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwg

b2YgQ2xpbmljYWwgTnV0cml0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0gSiBDbGluIE51dHI8

L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlv

bjwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmlj

YW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBK

IENsaW4gTnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmlj

YWwgTnV0cml0aW9uPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTcyNS0xNzMyPC9w

YWdlcz48dm9sdW1lPjkxPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlv

bj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkICpD

b2duaXRpb24vZGUgW0RydWcgRWZmZWN0c10gQ29nbml0aW9uL3BoIFtQaHlzaW9sb2d5XSBEaWV0

YXJ5IFN1cHBsZW1lbnRzIERvdWJsZS1CbGluZCBNZXRob2QgKkZhdHR5IEFjaWRzLE9tZWdhLTMv

YWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmF0dHkgQWNpZHMsT21lZ2EtMy9ibCBb

Qmxvb2RdIEZlbWFsZSBIdW1hbnMgTWFsZSBOZXVyb3BzeWNob2xvZ2ljYWwgVGVzdHMgUGF0aWVu

dCBDb21wbGlhbmNlIDAgKEZhdHR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw

MTA8L3llYXI+PC9kYXRlcz48aXNibj4xOTM4LTMyMDc8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8v

ZHguZG9pLm9yZy8xMC4zOTQ1L2FqY24uMjAwOS4yOTEyMTtSYW5kb21pemVkIENvbnRyb2xsZWQg

VHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dp

P1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZh

bXA7QU49MjA0MTAwODlodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVk

bGluZSZhbXA7aWQ9cG1pZDoyMDQxMDA4OSZhbXA7aWQ9ZG9pOjEwLjM5NDUlMkZhamNuLjIwMDku

MjkxMjEmYW1wO2lzc249MDAwMi05MTY1JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTkxJmFtcDtpc3N1

ZT02JmFtcDtzcGFnZT0xNzI1JmFtcDtwYWdlcz0xNzI1LTMyJmFtcDtkYXRlPTIwMTAmYW1wO3Rp

dGxlPUFtZXJpY2FuK0pvdXJuYWwrb2YrQ2xpbmljYWwrTnV0cml0aW9uJmFtcDthdGl0bGU9RWZm

ZWN0K29mKzIteStuLTMrbG9uZy1jaGFpbitwb2x5dW5zYXR1cmF0ZWQrZmF0dHkrYWNpZCtzdXBw

bGVtZW50YXRpb24rb24rY29nbml0aXZlK2Z1bmN0aW9uK2luK29sZGVyK3Blb3BsZSUzQSthK3Jh

bmRvbWl6ZWQlMkMrZG91YmxlLWJsaW5kJTJDK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9

RGFuZ291cjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+

PEF1dGhvcj5QYWxtYTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJlY051bT4xOTkwMDwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk5MDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDM1NTM2OSI+MTk5MDA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPlBhbG1hLCBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

dGl0bGVzPjx0aXRsZT5PbWVnYSAzIGZhdHR5IGFjaWRzIHN1cHBsZW1lbnRhdGlvbiBpbiBTY2hp

em9waHJlbmlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBz

eWNoaWF0cnkgYW5kIENsaW5pY2FsIE5ldXJvc2NpZW5jZTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0

bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0

cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFy

Y2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNo

aXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3Bl

cmlvZGljYWw+PHBhZ2VzPlMxMjItUzEyMjwvcGFnZXM+PHZvbHVtZT4yNjU8L3ZvbHVtZT48bnVt

YmVyPlN1cHBsZW1lbnQgMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE1PC95ZWFyPjwvZGF0ZXM+

PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlBvbXBvbmk8L0F1dGhv

cj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MTI3NjE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjEyNzYxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

NTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTY1

MzIiPjEyNzYxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Qb21wb25p

LCBNLjwvYXV0aG9yPjxhdXRob3I+TG9yaWEsIEcuPC9hdXRob3I+PGF1dGhvcj5TYWx2YXRpLCBT

LjwvYXV0aG9yPjxhdXRob3I+RGkgQmlhc2UsIEEuPC9hdXRob3I+PGF1dGhvcj5Db250ZSwgRy48

L2F1dGhvcj48YXV0aG9yPlZpbGxlbGxhLCBDLjwvYXV0aG9yPjxhdXRob3I+UmlnaGlubywgRS48

L2F1dGhvcj48YXV0aG9yPkNpY2lhcmVsbGksIEMuPC9hdXRob3I+PGF1dGhvcj5CcmlhLCBQLjwv

YXV0aG9yPjxhdXRob3I+TGEgVG9ycmUsIEcuPC9hdXRob3I+PGF1dGhvcj5Qb21wb25pLCBNLiBG

LiBMLjwvYXV0aG9yPjxhdXRob3I+SmFuaXJpLCBMLjwvYXV0aG9yPjxhdXRob3I+QmVudGl2b2ds

aW8sIEEuIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+

KFBvbXBvbmksIENvbnRlLCBWaWxsZWxsYSwgUmlnaGlubywgQ2ljaWFyZWxsaSwgQnJpYSwgSmFu

aXJpKSBJbnN0aXR1dGUgb2YgUHN5Y2hpYXRyeSwgRGVwYXJ0bWVudCBvZiBHZXJpYXRyaWNzLCBO

ZXVyb3NjaWVuY2UgYW5kIE9ydGhvcGFlZGljcywgVW5pdmVyc2l0YSBDYXR0b2xpY2EgZGVsIFNh

Y3JvIEN1b3JlIChVQ1NDKSwgUm9tYSwgSXRhbHkgKFBvbXBvbmkpIENlbnRybyBTdHVkaSBBY2hp

bGxlIGUgTGluZGEgTG9yZW56b24sIFRyZXZpc28sIEl0YWx5IChMb3JpYSwgQmVudGl2b2dsaW8p

IEluc3RpdHV0ZSBvZiBOZXVyb2xvZ3ksIFVDU0MsIFJvbWEsIEl0YWx5IChTYWx2YXRpLCBEaSBC

aWFzZSkgSXN0aXR1dG8gU3VwZXJpb3JlIGRpIFNhbml0YSwgUm9tYSwgSXRhbHkgKExhIFRvcnJl

KSBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGggYW5kIEluZmVjdGlvdXMgRGlzZWFzZXMsIExh

IFNhcGllbnphIFVuaXZlcnNpdHksIFJvbWEsIEl0YWx5IChQb21wb25pKSBJbnN0aXR1dGUgb2Yg

QmlvY2hlbWlzdHJ5IGFuZCBDbGluaWNhbCBCaW9jaGVtaXN0cnksIFVDU0MsIFJvbWEsIEl0YWx5

IE0uIFBvbXBvbmksIEluc3RpdHV0ZSBvZiBQc3ljaGlhdHJ5LCBEZXBhcnRtZW50IG9mIEdlcmlh

dHJpY3MsIE5ldXJvc2NpZW5jZSBhbmQgT3J0aG9wYWVkaWNzLCBVbml2ZXJzaXRhIENhdHRvbGlj

YSBkZWwgU2Fjcm8gQ3VvcmUgKFVDU0MpLCBSb21hLCBJdGFseS4gRS1tYWlsOiBtYXNzaW1pbGlh

bm9wb21wb25pQGFsaWNlLml0PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+REhBIGVmZmVj

dHMgaW4gUGFya2luc29uIGRpc2Vhc2UgZGVwcmVzc2lvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5CYXNhbCBHYW5nbGlhPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+QmFzYWwgR2FuZ2xpYTwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjYx

LTY2PC9wYWdlcz48dm9sdW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkRl

cHJlc3Npb24gRG9jb3NhaGV4YWVub2ljIGFjaWQgUGFya2luc29uJmFwb3M7cyBkaXNlYXNlIGFk

dWx0IGFuaGVkb25pYSBhbnhpZXR5IGFwYXRoeSBhcnRpY2xlIGNsaW5pY2FsIGFydGljbGUgY2xp

bmljYWwgZWZmZWN0aXZlbmVzcyBjb250cm9sbGVkIHN0dWR5IGRlcHJlc3Npb24vZHQgW0RydWcg

VGhlcmFweV0gZGlzZWFzZSBhc3NvY2lhdGlvbiBkb3VibGUgYmxpbmQgcHJvY2VkdXJlIGRydWcg

ZWZmZWN0IGZhdHR5IGFjaWQgYmxvb2QgbGV2ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MjIxMC01MzM2PC9pc2JuPjx3b3JrLXR5cGU+

aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmJhZ2EuMjAxNC4wMy4wMDQ8L3dvcmstdHlwZT48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5lbHNldmllci5jb20vd3BzL2ZpbmQv

am91cm5hbGRlc2NyaXB0aW9uLmN3c19ob21lLzcyNTQyMy9kZXNjcmlwdGlvbiNkZXNjcmlwdGlv

bmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1lbWVkMTImYW1wO0FOPTIwMTQzODA3NjVodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtpZD1wbWlkOiZh

bXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmJhZ2EuMjAxNC4wMy4wMDQmYW1wO2lzc249MjIxMC01MzM2

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTQmYW1wO2lzc3VlPTImYW1wO3NwYWdlPTYxJmFtcDtwYWdl

cz02MS02NiZhbXA7ZGF0ZT0yMDE0JmFtcDt0aXRsZT1CYXNhbCtHYW5nbGlhJmFtcDthdGl0bGU9

REhBK2VmZmVjdHMraW4rUGFya2luc29uK2Rpc2Vhc2UrZGVwcmVzc2lvbiZhbXA7YXVsYXN0PVBv

bXBvbmk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+UHJhdHQ8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNOdW0+MTI4NDk8L1JlY051

bT48cmVjb3JkPjxyZWMtbnVtYmVyPjEyODQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0

aW1lc3RhbXA9IjE1MzAyMTY1ODEiPjEyODQ5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5QcmF0dCwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlJlaWZmZWwsIEouIEEuPC9h

dXRob3I+PGF1dGhvcj5FbGxlbmJvZ2VuLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+TmFjY2FyZWxs

aSwgRy4gVi48L2F1dGhvcj48YXV0aG9yPktvd2V5LCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48

L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByYXR0LENyYWlnIE0uIE1ldGhvZGlzdCBEZUJh

a2V5IEhlYXJ0ICZhbXA7IFZhc2N1bGFyIENlbnRlciwgNjU2NSBGYW5uaW4gU3RyZWV0LCBGMTAw

MSwgSG91c3RvbiwgVFggNzcwMzAsIFVTQS4gY3ByYXR0QHRtaHMub3JnPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmaWNhY3kgYW5kIHNhZmV0eSBvZiBwcmVzY3JpcHRpb24gb21lZ2Et

My1hY2lkIGV0aHlsIGVzdGVycyBmb3IgdGhlIHByZXZlbnRpb24gb2YgcmVjdXJyZW50IHN5bXB0

b21hdGljIGF0cmlhbCBmaWJyaWxsYXRpb246IGEgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+QW0gSGVhcnQgSjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkFtZXJpY2FuIEhlYXJ0IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBIZWFy

dCBKPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSGVhcnQgSm91cm5hbDwvYWJici0yPjwv

cGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSGVhcnQgSm91

cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkFtIEhlYXJ0IEo8L2FiYnItMT48YWJici0yPlRoZSBB

bWVyaWNhbiBIZWFydCBKb3VybmFsPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTYz

LTE2OTwvcGFnZXM+PHZvbHVtZT4xNTg8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmlu

dC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3Jk

PkFudGktQXJyaHl0aG1pYSBBZ2VudHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0g

KkFudGktQXJyaHl0aG1pYSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkF0cmlhbCBGaWJy

aWxsYXRpb24vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRG9jb3NhaGV4YWVub2ljIEFj

aWRzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEb2Nvc2FoZXhhZW5vaWMgQWNp

ZHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRG91YmxlLUJsaW5kIE08L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjEwOTctNjc0NDwvaXNibj48

d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5haGouMjAwOS4wNS4wMjQ7UmFu

ZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZh

cG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5v

dmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1

bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE5NjE5NjkwaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4

X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTk2MTk2OTAmYW1wO2lkPWRvaTox

MC4xMDE2JTJGai5haGouMjAwOS4wNS4wMjQmYW1wO2lzc249MDAwMi04NzAzJmFtcDtpc2JuPSZh

bXA7dm9sdW1lPTE1OCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9MTYzJmFtcDtwYWdlcz0xNjMtMTY5

LmUxLTMmYW1wO2RhdGU9MjAwOSZhbXA7dGl0bGU9QW1lcmljYW4rSGVhcnQrSm91cm5hbCZhbXA7

YXRpdGxlPUVmZmljYWN5K2FuZCtzYWZldHkrb2YrcHJlc2NyaXB0aW9uK29tZWdhLTMtYWNpZCtl

dGh5bCtlc3RlcnMrZm9yK3RoZStwcmV2ZW50aW9uK29mK3JlY3VycmVudCtzeW1wdG9tYXRpYyth

dHJpYWwrZmlicmlsbGF0aW9uJTNBK2ErcHJvc3BlY3RpdmUrc3R1ZHkuJmFtcDthdWxhc3Q9UHJh

dHQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRo

b3I+U2lubjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT4xNDkwOTwvUmVjTnVtPjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTQ5MDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxNzc3MiI+MTQ5MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPlNpbm4sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWx0ZSwgQy4gTS48L2F1dGhvcj48YXV0

aG9yPlN0cmVldCwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkJ1Y2tsZXksIEouIEQuPC9hdXRob3I+

PGF1dGhvcj5Db2F0ZXMsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5QZXRrb3YsIEouPC9hdXRob3I+

PGF1dGhvcj5Ib3dlLCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPlNpbm4sTmF0YWxpZS4gU2Nob29sIG9mIEhlYWx0aCBTY2llbmNlcywgU2Fuc29t

IEluc3RpdHV0ZSBmb3IgSGVhbHRoIFJlc2VhcmNoLCBOdXRyaXRpb25hbCBQaHlzaW9sb2d5IFJl

c2VhcmNoIENlbnRyZSwgVW5pdmVyc2l0eSBvZiBTb3V0aCBBdXN0cmFsaWEsIEdQTyBCb3ggMjQ3

MSwgQWRlbGFpZGUsIFNBIDUwMDEsIEF1c3RyYWxpYS4gbmF0YWxpZS5zaW5uQHVuaXNhLmVkdS5h

dTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIGZhdHR5IGFjaWRz

LCBFUEEgdi4gREhBLCBvbiBkZXByZXNzaXZlIHN5bXB0b21zLCBxdWFsaXR5IG9mIGxpZmUsIG1l

bW9yeSBhbmQgZXhlY3V0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIGFkdWx0cyB3aXRoIG1pbGQgY29n

bml0aXZlIGltcGFpcm1lbnQ6IGEgNi1tb250aCByYW5kb21pc2VkIGNvbnRyb2xsZWQgdHJpYWw8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10

aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48

YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE2ODItMTY5

MzwvcGFnZXM+PHZvbHVtZT4xMDc8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PHJlcHJpbnQt

ZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5B

Z2VkIEFnZWQsODAgYW5kIG92ZXIgQXVzdHJhbGlhIENvZ25pdGlvbiBEaXNvcmRlcnMvYmwgW0Js

b29kXSAqQ29nbml0aW9uIERpc29yZGVycy9kaCBbRGlldCBUaGVyYXB5XSBDb2duaXRpb24gRGlz

b3JkZXJzL3BwIFtQaHlzaW9wYXRob2xvZ3ldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHggW1BzeWNo

b2xvZ3ldIERlcHJlc3Npb24vYmwgW0Jsb29kXSAqRGVwcmVzc2lvbi9kaCBbRGlldCBUaGVyYXB5

XSBEZXByZXNzaW9uL3BwIFtQaHlzaW9wPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTI8L3llYXI+PC9kYXRlcz48aXNibj4xNDc1LTI2NjI8L2lzYm4+PHdvcmstdHlwZT5odHRw

Oi8vZHguZG9pLm9yZy8xMC4xMDE3L1MwMDA3MTE0NTExMDA0Nzg4O0NvbXBhcmF0aXZlIFN0dWR5

IE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBT

dXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJs

cz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkm

YW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMTkyOTgzNWh0

dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlk

OjIxOTI5ODM1JmFtcDtpZD1kb2k6MTAuMTAxNyUyRlMwMDA3MTE0NTExMDA0Nzg4JmFtcDtpc3Nu

PTAwMDctMTE0NSZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xMDcmYW1wO2lzc3VlPTExJmFtcDtzcGFn

ZT0xNjgyJmFtcDtwYWdlcz0xNjgyLTkzJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUJyaXRpc2gr

Sm91cm5hbCtvZitOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3RzK29mK24tMytmYXR0eSthY2lk

cyUyQytFUEErdi4rREhBJTJDK29uK2RlcHJlc3NpdmUrc3ltcHRvbXMlMkMrcXVhbGl0eStvZits

aWZlJTJDK21lbW9yeSthbmQrZXhlY3V0aXZlK2Z1bmN0aW9uK2luK29sZGVyK2FkdWx0cyt3aXRo

K21pbGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYSs2LW1vbnRoK3JhbmRvbWlzZWQrY29udHJv

bGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1TaW5uPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkdhbGFuPC9BdXRob3I+PFllYXI+MjAxMDwvWWVh

cj48UmVjTnVtPjUyMzY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjUyMzY8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBl

dmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxMjMwMCI+NTIzNjwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R2FsYW4sIFAuPC9hdXRob3I+PGF1dGhvcj5L

ZXNzZS1HdXlvdCwgRS48L2F1dGhvcj48YXV0aG9yPkN6ZXJuaWNob3csIFMuPC9hdXRob3I+PGF1

dGhvcj5CcmlhbmNvbiwgUy48L2F1dGhvcj48YXV0aG9yPkJsYWNoZXIsIEouPC9hdXRob3I+PGF1

dGhvcj5IZXJjYmVyZywgUy48L2F1dGhvcj48YXV0aG9yPkdyb3VwLCBTdSBGb2wgT20gQ29sbGFi

b3JhdGl2ZTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkdh

bGFuLFBpbGFyLiBVTVIgVTU1NyBJbnNlcm0sIFUxMTI1IElucmEsIENuYW0sIFVuaXZlcnNpdGUg

UGFyaXMgMTMsIENSTkggSWRGLCBGLTkzMDE3IEJvYmlnbnksIEZyYW5jZS4gcC5nYWxhbkB1cmVu

LnNtYmgudW5pdi1wYXJpczEzLmZyPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0

cyBvZiBCIHZpdGFtaW5zIGFuZCBvbWVnYSAzIGZhdHR5IGFjaWRzIG9uIGNhcmRpb3Zhc2N1bGFy

IGRpc2Vhc2VzOiBhIHJhbmRvbWlzZWQgcGxhY2VibyBjb250cm9sbGVkIHRyaWFsPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkJNSjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Qm1qPC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBNZWRpY2FsIEpv

dXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBNZWQgSjwvYWJici0xPjxhYmJyLTI+Qk1KPC9h

YmJyLTI+PGFiYnItMz5CbWo8L2FiYnItMz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkJyaXRpc2ggTWVkaWNhbCBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QnIg

TWVkIEo8L2FiYnItMT48YWJici0yPkJNSjwvYWJici0yPjxhYmJyLTM+Qm1qPC9hYmJyLTM+PC9h

bHQtcGVyaW9kaWNhbD48cGFnZXM+YzYyNzM8L3BhZ2VzPjx2b2x1bWU+MzQxPC92b2x1bWU+PHJl

cHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQW5naW5hLFVuc3RhYmxlL2RoIFtEaWV0IFRoZXJh

cHldIEJpb21hcmtlcnMvYmwgW0Jsb29kXSAqQ2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvcGMgW1By

ZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50cyBEb3VibGUtQmxpbmQg

TWV0aG9kICpGYXR0eSBBY2lkcyxPbWVnYS02L2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3Nh

Z2VdIEZhdHR5IEFjaWRzLE9tZWdhLTYvYmwgW0Jsb29kXSBGPC9rZXl3b3JkPjwva2V5d29yZHM+

PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48aXNibj4xNzU2LTE4MzM8L2lzYm4+PHdv

cmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMTM2L2Jtai5jNjI3MztNdWx0aWNlbnRlciBT

dHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUu

Uy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8v

b3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1w

O1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjExMTU1ODlodHRwOi8vc2Z4LnVjbC5h

Yy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMTExNTU4OSZhbXA7

aWQ9ZG9pOjEwLjExMzYlMkZibWouYzYyNzMmYW1wO2lzc249MDk1OS01MzVYJmFtcDtpc2JuPSZh

bXA7dm9sdW1lPTM0MSZhbXA7aXNzdWU9MjkmYW1wO3NwYWdlPWM2MjczJmFtcDtwYWdlcz1jNjI3

MyZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1CTUomYW1wO2F0aXRsZT1FZmZlY3RzK29mK0Irdml0

YW1pbnMrYW5kK29tZWdhKzMrZmF0dHkrYWNpZHMrb24rY2FyZGlvdmFzY3VsYXIrZGlzZWFzZXMl

M0ErYStyYW5kb21pc2VkK3BsYWNlYm8rY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1HYWxh

bjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+MTU2ODU8

L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE1Njg1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtl

eXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVm

czB0IiB0aW1lc3RhbXA9IjE1MzAyMTgyMTUiPjE1Njg1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5UYWphbGl6YWRla2hvb2IsIFkuPC9hdXRob3I+PGF1dGhvcj5TaGFy

aWZpLCBGLjwvYXV0aG9yPjxhdXRob3I+RmFraHJ6YWRlaCwgSC48L2F1dGhvcj48YXV0aG9yPk1p

cmFyZWZpbiwgTS48L2F1dGhvcj48YXV0aG9yPkdoYWRlcnBhbmFoaSwgTS48L2F1dGhvcj48YXV0

aG9yPkJhZGFtY2hpemFkZSwgWi48L2F1dGhvcj48YXV0aG9yPkF6aW1pcG91ciwgUy48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UYWphbGl6YWRla2==

ADDIN EN.CITE.DATA aG9vYixZYXNlci4gRW5kb2NyaW5vbG9neSBhbmQgTWV0YWJvbGlzbSBSZXNlYXJjaCBDZW50ZXIs

IFRlaHJhbiBVbml2ZXJzaXR5IG9mIE1lZGljYWwgU2NpZW5jZXMsIDV0aCBmbG9vciwgRHIgU2hh

cmVlYXRpIEhvc3BpdGFsLCBOb3J0aCBLYXJlZ2FyIEF2ZW51ZSwgVGVocmFuLCBJcmFuPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVmZmVjdCBvZiBsb3ctZG9zZSBvbWVnYSAzIGZh

dHR5IGFjaWRzIG9uIHRoZSB0cmVhdG1lbnQgb2YgbWlsZCB0byBtb2RlcmF0ZSBkZXByZXNzaW9u

IGluIHRoZSBlbGRlcmx5OiBhIGRvdWJsZS1ibGluZCwgcmFuZG9taXplZCwgcGxhY2Viby1jb250

cm9sbGVkIHN0dWR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9m

IFBzeWNoaWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5FdXIgQXJjaCBQc3ljaGlhdHJ5IENsaW4gTmV1cm9zY2k8L2FsdC10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBBcmNoaXZlcyBvZiBQc3lj

aGlhdHJ5ICZhbXA7IENsaW5pY2FsIE5ldXJvc2NpZW5jZTwvZnVsbC10aXRsZT48YWJici0xPkV1

ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWJici0xPjxhYmJyLTI+RXVyb3BlYW4g

QXJjaGl2ZXMgb2YgUHN5Y2hpYXRyeSBhbmQgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9hYmJyLTI+

PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBBcmNoaXZl

cyBvZiBQc3ljaGlhdHJ5ICZhbXA7IENsaW5pY2FsIE5ldXJvc2NpZW5jZTwvZnVsbC10aXRsZT48

YWJici0xPkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWJici0xPjxhYmJyLTI+

RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRyeSBhbmQgQ2xpbmljYWwgTmV1cm9zY2llbmNl

PC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NTM5LTU0OTwvcGFnZXM+PHZvbHVtZT4y

NjE8L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxF

PC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3Zl

ciBBbnRpZGVwcmVzc2l2ZSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkRlcHJlc3Npb24v

ZHQgW0RydWcgVGhlcmFweV0gRGlldCBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcgSHlwZXJzZW5z

aXRpdml0eSBGYXR0eSBBY2lkcyxPbWVnYS0zL2FlIFtBZHZlcnNlIEVmZmVjdHNdICpGYXR0eSBB

Y2lkcyxPbWVnYS0zL3R1IFtUaGVyYXBldXRpYyBVc2VdIEZlbWFsZSBGaXNoIE9pbHMvYWQgW0Fk

bWluaTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTQzMy04NDkxPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAw

Ny9zMDA0MDYtMDExLTAxOTEtOTtSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2gg

U3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1Z

JmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjEzMTg0NTJo

dHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1p

ZDoyMTMxODQ1MiZhbXA7aWQ9ZG9pOjEwLjEwMDclMkZzMDA0MDYtMDExLTAxOTEtOSZhbXA7aXNz

bj0wOTQwLTEzMzQmYW1wO2lzYm49JmFtcDt2b2x1bWU9MjYxJmFtcDtpc3N1ZT04JmFtcDtzcGFn

ZT01MzkmYW1wO3BhZ2VzPTUzOS00OSZhbXA7ZGF0ZT0yMDExJmFtcDt0aXRsZT1FdXJvcGVhbitB

cmNoaXZlcytvZitQc3ljaGlhdHJ5KyUyNitDbGluaWNhbCtOZXVyb3NjaWVuY2UmYW1wO2F0aXRs

ZT1UaGUrZWZmZWN0K29mK2xvdy1kb3NlK29tZWdhKzMrZmF0dHkrYWNpZHMrb24rdGhlK3RyZWF0

bWVudCtvZittaWxkK3RvK21vZGVyYXRlK2RlcHJlc3Npb24raW4rdGhlK2VsZGVybHklM0ErYStk

b3VibGUtYmxpbmQlMkMrcmFuZG9taXplZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrc3R1ZHkuJmFt

cDthdWxhc3Q9VGFqYWxpemFkZWtob29iPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVj

b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlR1dHRsZTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+

PFJlY051bT4xNjI4NzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTYyODc8L3JlYy1udW1i

ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBl

dmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxODU0OSI+MTYyODc8L2tleT48L2Zv

cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+

PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlR1dHRsZSwgSy4gUi48L2F1dGhvcj48YXV0

aG9yPlNodWxlciwgTC4gQS48L2F1dGhvcj48YXV0aG9yPlBhY2thcmQsIEQuIFAuPC9hdXRob3I+

PGF1dGhvcj5NaWx0b24sIEouIEUuPC9hdXRob3I+PGF1dGhvcj5EYXJhdGhhLCBLLiBCLjwvYXV0

aG9yPjxhdXRob3I+QmlidXMsIEQuIE0uPC9hdXRob3I+PGF1dGhvcj5TaG9ydCwgUi4gQS48L2F1

dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5UdXR0bGUsS2F0aGVy

aW5lIFIuIFRoZSBIZWFydCBJbnN0aXR1dGUgb2YgU3Bva2FuZSwgU2FjcmVkIEhlYXJ0IE1lZGlj

YWwgQ2VudGVyLCBTcG9rYW5lLCBXYXNoaW5ndG9uLCBVU0EuIGt0dXR0bGVAc2htYy5vcmc8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Db21wYXJpc29uIG9mIGxvdy1mYXQgdmVyc3VzIE1l

ZGl0ZXJyYW5lYW4tc3R5bGUgZGlldGFyeSBpbnRlcnZlbnRpb24gYWZ0ZXIgZmlyc3QgbXlvY2Fy

ZGlhbCBpbmZhcmN0aW9uIChmcm9tIFRoZSBIZWFydCBJbnN0aXR1dGUgb2YgU3Bva2FuZSBEaWV0

IEludGVydmVudGlvbiBhbmQgRXZhbHVhdGlvbiBUcmlhbCk8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5BbSBKIENhcmRpb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRpb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5B

bSBKIENhcmRpb2w8L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L2FiYnItMj48YWJici0zPlRoZSBhbWVyaWNhbiBqb3VybmFsIG9mIGNhcmRpb2xvZ3k8

L2FiYnItMz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2Fu

IEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwv

YWJici0xPjxhYmJyLTI+VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0y

PjxhYmJyLTM+VGhlIGFtZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvYWx0

LXBlcmlvZGljYWw+PHBhZ2VzPjE1MjMtMTUzMDwvcGFnZXM+PHZvbHVtZT4xMDE8L3ZvbHVtZT48

bnVtYmVyPjExPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5Db25maWRlbmNlIEludGVydmFscyAqRGlldCxGYXQt

UmVzdHJpY3RlZC9tdCBbTWV0aG9kc10gKkRpZXQsTWVkaXRlcnJhbmVhbiBEaXNlYXNlLUZyZWUg

U3Vydml2YWwgRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEh1bWFucyBNYWxlIE1pZGRsZSBBZ2Vk

ICpNeW9jYXJkaWFsIEluZmFyY3Rpb24vZGggW0RpZXQgVGhlcmFweV0gTXlvY2FyZGlhbCBJbmZh

cmN0aW9uL2VwIFtFcGlkZW1pb2xvZ3ldIE9kZHMgUmF0aW8gUmV0cm9zcGVjdGl2ZSBTPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PC9kYXRlcz48aXNibj4wMDAy

LTkxNDk8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYW1qY2Fy

ZC4yMDA4LjAxLjAzODtDb21wYXJhdGl2ZSBTdHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJp

YWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxz

PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9

SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7

QU49MTg0ODk5MjdodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGlu

ZSZhbXA7aWQ9cG1pZDoxODQ4OTkyNyZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmFtamNhcmQuMjAw

OC4wMS4wMzgmYW1wO2lzc249MDAwMi05MTQ5JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTEwMSZhbXA7

aXNzdWU9MTEmYW1wO3NwYWdlPTE1MjMmYW1wO3BhZ2VzPTE1MjMtMzAmYW1wO2RhdGU9MjAwOCZh

bXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitDYXJkaW9sb2d5JmFtcDthdGl0bGU9Q29tcGFy

aXNvbitvZitsb3ctZmF0K3ZlcnN1cytNZWRpdGVycmFuZWFuLXN0eWxlK2RpZXRhcnkraW50ZXJ2

ZW50aW9uK2FmdGVyK2ZpcnN0K215b2NhcmRpYWwraW5mYXJjdGlvbislMjhmcm9tK1RoZStIZWFy

dCtJbnN0aXR1dGUrb2YrU3Bva2FuZStEaWV0K0ludGVydmVudGlvbithbmQrRXZhbHVhdGlvbitU

cmlhbCUyOS4mYW1wO2F1bGFzdD1UdXR0bGU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+SHVudGluZ3RvbiBTdHVkeTwvQXV0aG9yPjxZZWFy

PjIwMDg8L1llYXI+PFJlY051bT43MTQzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj43MTQz

PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVq

cnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTMzNjgiPjcxNDM8

L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv

cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkh1bnRpbmd0b24gU3R1ZHkg

R3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlJh

bmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBvZiBldGh5bC1laWNvc2FwZW50YWVub2ljIGFjaWQg

aW4gSHVudGluZ3RvbiBkaXNlYXNlOiB0aGUgVFJFTkQtSEQgc3R1ZHk8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+QXJjaGl2ZXMgb2YgTmV1cm9sb2d5PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5BcmNoIE5ldXJvbDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFyY2ggTmV1cm9sPC9h

YmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoaXZlcyBv

ZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoIE5ldXJvbDwvYWJici0xPjwvYWx0

LXBlcmlvZGljYWw+PHBhZ2VzPjE1ODItMTU4OTwvcGFnZXM+PHZvbHVtZT42NTwvdm9sdW1lPjxu

dW1iZXI+MTI8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0IEFuYWx5c2lzIG9mIFZhcmlhbmNlIENhbmFk

YSBEb3VibGUtQmxpbmQgTWV0aG9kICpFaWNvc2FwZW50YWVub2ljIEFjaWQvYWEgW0FuYWxvZ3Mg

JmFtcDsgRGVyaXZhdGl2ZXNdIEVpY29zYXBlbnRhZW5vaWMgQWNpZC90dSBbVGhlcmFwZXV0aWMg

VXNlXSBGZW1hbGUgRm9sbG93LVVwIFN0dWRpZXMgSHVtYW5zICpIdW50aW5ndG9uIERpc2Vhc2Uv

ZHQgW0RydWcgVGhlcmFweV0gSHVudGluZ3RvbiBEaXNlYXNlL2dlIFtHZW5ldGljc10gKkh1PC9r

ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PC9kYXRlcz48aXNibj4x

NTM4LTM2ODc8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAxL2FyY2hu

ZXVyLjY1LjEyLjE1ODI7Q2xpbmljYWwgVHJpYWwgTXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXpl

ZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8

L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNv

bS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0

JmFtcDtEPW1lZDUmYW1wO0FOPTE5MDY0NzQ1aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2Fs

P3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTkwNjQ3NDUmYW1wO2lkPWRvaToxMC4xMDAx

JTJGYXJjaG5ldXIuNjUuMTIuMTU4MiZhbXA7aXNzbj0wMDAzLTk5NDImYW1wO2lzYm49JmFtcDt2

b2x1bWU9NjUmYW1wO2lzc3VlPTEyJmFtcDtzcGFnZT0xNTgyJmFtcDtwYWdlcz0xNTgyLTkmYW1w

O2RhdGU9MjAwOCZhbXA7dGl0bGU9QXJjaGl2ZXMrb2YrTmV1cm9sb2d5JmFtcDthdGl0bGU9UmFu

ZG9taXplZCtjb250cm9sbGVkK3RyaWFsK29mK2V0aHlsLWVpY29zYXBlbnRhZW5vaWMrYWNpZCtp

bitIdW50aW5ndG9uK2Rpc2Vhc2UlM0ErdGhlK1RSRU5ELUhEK3N0dWR5LiZhbXA7YXVsYXN0PUh1

bnRpbmd0b24rU3R1ZHkrR3JvdXArVFJFTkQtSEQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+

PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QVNDRU5EIFN0dWR5IENvbGxhYm9yYXRpdmUg

R3JvdXA8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNOdW0+MjE3MDE8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjIxNzAxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1NDIxNDA2MjkiPjIxNzAxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5BU0NFTkQgU3R1ZHkgQ29sbGFib3JhdGl2ZSBHcm91cCw8L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+RWZmZWN0cyBvZiBu4oiSMyBGYXR0eSBBY2lk

IFN1cHBsZW1lbnRzIGluIERpYWJldGVzIE1lbGxpdHVzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

Pk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5l

PC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpNPC9h

YmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJici0z

PjwvcGVyaW9kaWNhbD48cGFnZXM+MTU0MC0xNTUwPC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1l

PjxudW1iZXI+MTY8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxk

YXRlPjIwMTgvMTAvMTg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPk1hc3Nh

Y2h1c2V0dHMgTWVkaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAyOC00NzkzPC9pc2Ju

Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL2RvaS5vcmcvMTAuMTA1Ni9ORUpNb2Ex

ODA0OTg5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51

bT4xMC4xMDU2L05FSk1vYTE4MDQ5ODk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3Mt

ZGF0ZT4yMDE4LzExLzEzPC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5BbmRyaWV1PC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVjTnVtPjIxOTk0PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4yMTk5NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGlt

ZXN0YW1wPSIxNTUwMDc3OTg2Ij4yMTk5NDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3Jz

PjxhdXRob3I+QW5kcmlldSwgU2FuZHJpbmU8L2F1dGhvcj48YXV0aG9yPkd1eW9ubmV0LCBTb3Bo

aWU8L2F1dGhvcj48YXV0aG9yPkNvbGV5LCBOaWNvbGE8L2F1dGhvcj48YXV0aG9yPkNhbnRldCwg

Q2hyaXN0ZWxsZTwvYXV0aG9yPjxhdXRob3I+Qm9ubmVmb3ksIE1hcmM8L2F1dGhvcj48YXV0aG9y

PkJvcmRlcywgU2VyZ2U8L2F1dGhvcj48YXV0aG9yPkJvcmllcywgTGF3cmVuY2U8L2F1dGhvcj48

YXV0aG9yPkN1ZmksIE1hcmllLU5vw6tsbGU8L2F1dGhvcj48YXV0aG9yPkRhbnRvaW5lLCBUaGll

cnJ5PC9hdXRob3I+PGF1dGhvcj5EYXJ0aWd1ZXMsIEplYW4tRnJhbsOnb2lzPC9hdXRob3I+PGF1

dGhvcj5EZXNjbGF1eCwgRnJhbsOnb2lzZTwvYXV0aG9yPjxhdXRob3I+R2FiZWxsZSwgQXVkcmV5

PC9hdXRob3I+PGF1dGhvcj5HYXNuaWVyLCBZYW5uaWNrPC9hdXRob3I+PGF1dGhvcj5QZXNjZSwg

QWxhaW48L2F1dGhvcj48YXV0aG9yPlN1ZHJlcywgS3Jpc3RlbDwvYXV0aG9yPjxhdXRob3I+VG91

Y2hvbiwgSmFjcXVlczwvYXV0aG9yPjxhdXRob3I+Um9iZXJ0LCBQaGlsaXBwZTwvYXV0aG9yPjxh

dXRob3I+Um91YXVkLCBPbGl2aWVyPC9hdXRob3I+PGF1dGhvcj5MZWdyYW5kLCBQaGlsaXBwZTwv

YXV0aG9yPjxhdXRob3I+UGF5b3V4LCBQaWVycmU8L2F1dGhvcj48YXV0aG9yPkNhdWJlcmUsIEpl

YW4tUGF1bDwvYXV0aG9yPjxhdXRob3I+V2VpbmVyLCBNaWNoYWVsPC9hdXRob3I+PGF1dGhvcj5D

YXJyacOpLCBJc2FiZWxsZTwvYXV0aG9yPjxhdXRob3I+T3Vzc2V0LCBQaWVycmUtSmVhbjwvYXV0

aG9yPjxhdXRob3I+VmVsbGFzLCBCcnVubzwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48dGl0bGVzPjx0aXRsZT5FZmZlY3Qgb2YgbG9uZy10ZXJtIG9tZWdhIDMgcG9seXVuc2F0dXJh

dGVkIGZhdHR5IGFjaWQgc3VwcGxlbWVudGF0aW9uIHdpdGggb3Igd2l0aG91dCBtdWx0aWRvbWFp

biBpbnRlcnZlbnRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIGVsZGVybHkgYWR1bHRzIHdp

dGggbWVtb3J5IGNvbXBsYWludHMgKE1BUFQpOiBhIHJhbmRvbWlzZWQsIHBsYWNlYm8tY29udHJv

bGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaGUgTGFuY2V0IE5ldXJvbG9neTwv

c2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlRoZSBMYW5j

ZXQgTmV1cm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+TGFuY2V0IE5ldXJvbDwvYWJici0xPjxh

YmJyLTI+VGhlIExhbmNldC4gTmV1cm9sb2d5PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4z

NzctMzg5PC9wYWdlcz48dm9sdW1lPjE2PC92b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGRhdGVz

Pjx5ZWFyPjIwMTc8L3llYXI+PC9kYXRlcz48cHVibGlzaGVyPkVsc2V2aWVyPC9wdWJsaXNoZXI+

PGlzYm4+MTQ3NC00NDIyPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL2Rv

aS5vcmcvMTAuMTAxNi9TMTQ3NC00NDIyKDE3KTMwMDQwLTY8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPkRPSTogMTAuMTAxNi9TMTQ3NC00NDIyKDE3

KTMwMDQwLTY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3MtZGF0ZT4yMDE5LzAyLzEz

PC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (2-33) (41,470 participants) assessed effects of LCn3, one assessed effects of ALAPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzNCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+R2VsZWlqbnNlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0MTA8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxMjM5NyI+NTQxMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+R2VsZWlqbnNlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLjwvYXV0

aG9yPjxhdXRob3I+S3JvbWhvdXQsIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+KEdlbGVpam5zZSwgS3JvbWhvdXQpIFdhZ2VuaW5nZW4gVW5pdmVyc2l0

eSwgV2FnZW5pbmdlbiwgTmV0aGVybGFuZHMgKEdpbHRheSkgTGVpZGVuIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIsIExlaWRlbiwgTmV0aGVybGFuZHMgSi4gR2VsZWlqbnNlLCBXYWdlbmluZ2Vu

IFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIE5ldGhlcmxhbmRzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0cyBvZiBuLTMgZmF0dHlhY2lkcyBvbiBjb2duaXRpdmUgZGVjbGluZTog

QSByYW5kb21pemVkIGRvdWJsZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIGluIHN0

YWJsZSBteW9jYXJkaWFsIGluZmFyY3Rpb24gcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJi

ci0yPkFsemhlaW1lciZhcG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWlt

ZXJzIGFuZCBEZW1lbnRpYTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+UzUxMjwvcGFnZXM+

PHZvbHVtZT4xKTwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+cGF0aWVudCBodW1hbiBjb250cm9sbGVkIHN0dWR5

IGhlYXJ0IGluZmFyY3Rpb24gTWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gc3VwcGxlbWVu

dGF0aW9uIGNvZ25pdGlvbiBtZW50YWwgaGVhbHRoIGV4YW1pbmF0aW9uIGZvbGxvdyB1cCBnZW5k

ZXIgbG93IGRydWcgZG9zZSB2ZWdldGFibGUgaXNjaGVtaWMgaGVhcnQgZGlzZWFzZSBtYWxlIGNh

cmRpb3Zhc2N1bGFyIGRpc2Vhc2UgZmlzaCBmYWN0b3JpYWwgZGVzaWduIGNvaG9ydCBhbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01MjYwPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMS4wNS4xNDMyO0NvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMCZhbXA7QU49NzA1

MDIxMzRodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtp

ZD1wbWlkOiZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmphbHouMjAxMS4wNS4xNDMyJmFtcDtpc3Nu

PTE1NTItNTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT03JmFtcDtpc3N1ZT00K1NVUFBMLisxJmFt

cDtzcGFnZT1TNTEyJmFtcDtwYWdlcz1TNTEyJmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUFsemhl

aW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHlhY2lk

cytvbitjb2duaXRpdmUrZGVjbGluZSUzQStBK3JhbmRvbWl6ZWQrZG91YmxlLWJsaW5kJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtpbitzdGFibGUrbXlvY2FyZGlhbCtpbmZhcmN0aW9uK3Bh

dGllbnRzJmFtcDthdWxhc3Q9R2VsZWlqbnNlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzNCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+R2VsZWlqbnNlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0MTA8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxMjM5NyI+NTQxMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+R2VsZWlqbnNlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLjwvYXV0

aG9yPjxhdXRob3I+S3JvbWhvdXQsIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+KEdlbGVpam5zZSwgS3JvbWhvdXQpIFdhZ2VuaW5nZW4gVW5pdmVyc2l0

eSwgV2FnZW5pbmdlbiwgTmV0aGVybGFuZHMgKEdpbHRheSkgTGVpZGVuIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIsIExlaWRlbiwgTmV0aGVybGFuZHMgSi4gR2VsZWlqbnNlLCBXYWdlbmluZ2Vu

IFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIE5ldGhlcmxhbmRzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0cyBvZiBuLTMgZmF0dHlhY2lkcyBvbiBjb2duaXRpdmUgZGVjbGluZTog

QSByYW5kb21pemVkIGRvdWJsZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIGluIHN0

YWJsZSBteW9jYXJkaWFsIGluZmFyY3Rpb24gcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJi

ci0yPkFsemhlaW1lciZhcG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWlt

ZXJzIGFuZCBEZW1lbnRpYTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+UzUxMjwvcGFnZXM+

PHZvbHVtZT4xKTwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+cGF0aWVudCBodW1hbiBjb250cm9sbGVkIHN0dWR5

IGhlYXJ0IGluZmFyY3Rpb24gTWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gc3VwcGxlbWVu

dGF0aW9uIGNvZ25pdGlvbiBtZW50YWwgaGVhbHRoIGV4YW1pbmF0aW9uIGZvbGxvdyB1cCBnZW5k

ZXIgbG93IGRydWcgZG9zZSB2ZWdldGFibGUgaXNjaGVtaWMgaGVhcnQgZGlzZWFzZSBtYWxlIGNh

cmRpb3Zhc2N1bGFyIGRpc2Vhc2UgZmlzaCBmYWN0b3JpYWwgZGVzaWduIGNvaG9ydCBhbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01MjYwPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMS4wNS4xNDMyO0NvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMCZhbXA7QU49NzA1

MDIxMzRodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtp

ZD1wbWlkOiZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmphbHouMjAxMS4wNS4xNDMyJmFtcDtpc3Nu

PTE1NTItNTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT03JmFtcDtpc3N1ZT00K1NVUFBMLisxJmFt

cDtzcGFnZT1TNTEyJmFtcDtwYWdlcz1TNTEyJmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUFsemhl

aW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHlhY2lk

cytvbitjb2duaXRpdmUrZGVjbGluZSUzQStBK3JhbmRvbWl6ZWQrZG91YmxlLWJsaW5kJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtpbitzdGFibGUrbXlvY2FyZGlhbCtpbmZhcmN0aW9uK3Bh

dGllbnRzJmFtcDthdWxhc3Q9R2VsZWlqbnNlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (2, 34) (4837 participants, these participants were part of a factorial trial so also included in an LCn3 trial) and one assessed effects of higher total PUFA ADDIN EN.CITE <EndNote><Cite><Author>Estruch</Author><Year>2018</Year><RecNum>18084</RecNum><DisplayText>(35)</DisplayText><record><rec-number>18084</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530303952">18084</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Estruch, R.</author><author>Ros, E.</author><author>Salas-Salvadó, J.</author><author>Covas, M.</author><author>Corella, D.</author><author>Arós F et, a l</author></authors></contributors><titles><title>Retraction and republication: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368:1279-90</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N Engl J Med</abbr-1><abbr-2>NEJM</abbr-2><abbr-3>The New England Journal of Medicine</abbr-3></periodical><pages>25-25</pages><volume>378</volume><dates><year>2018</year></dates><urls></urls></record></Cite></EndNote>(35) (4997 participants). We found no trials assessing effects of omega-6 fatty acids on depression or anxiety. Fourteen RCTs assessed risk of serious depression symptoms, seventeen depression symptoms (assessed as a continuous measure in those without depression at baseline), one severity of depression in people with depression at baseline and five assessed anxiety. Participants were recruited with chronic illness or risk factors in 17 trials (6 with CVD, 3 diabetes or impaired glucose tolerance, 1 dyslipidaemia or hypertension, 2 with Huntingdon’s disease, 1 each with multiple sclerosis, non-alcoholic fatty liver disease, macular degeneration, Parkinson’s disease or colorectal tumours), memory deficit, cognitive impairment or Alzheimer’s disease in 6 trials, mental health problems in 4 trials (two with schizophrenia, 1 young people at high risk of psychotic disorders, 1 mild to moderate depression), and healthy participants in 5 trials. Of the 31 LCn3 trials, most gave supplementary capsules or medicinal oils, but two used supplemental foods (enriched margarine and fish sausages) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAyMSk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+SGFzaGltb3RvPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVjTnVtPjIwMjIzPC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDIyMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMw

dCIgdGltZXN0YW1wPSIxNTMwMzU1NTM0Ij4yMDIyMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYt

dHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxh

dXRob3JzPjxhdXRob3I+SGFzaGltb3RvLCBNLjwvYXV0aG9yPjxhdXRob3I+S2F0bywgUy48L2F1

dGhvcj48YXV0aG9yPlRhbmFiZSwgWS48L2F1dGhvcj48YXV0aG9yPkthdGFrdXJhLCBNLjwvYXV0

aG9yPjxhdXRob3I+TWFtdW4sIEEuIEEuPC9hdXRob3I+PGF1dGhvcj5PaG5vLCBNLjwvYXV0aG9y

PjxhdXRob3I+ZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVz

Pjx0aXRsZT5CZW5lZmljaWFsIGVmZmVjdHMgb2YgZGlldGFyeSBkb2Nvc2FoZXhhZW5vaWMgYWNp

ZCBpbnRlcnZlbnRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGFuZCBtZW50YWwgaGVhbHRoIG9m

IHRoZSBvbGRlc3QgZWxkZXJseSBpbiBKYXBhbmVzZSBjYXJlIGZhY2lsaXRpZXMgYW5kIG51cnNp

bmcgaG9tZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+R2VyaWF0cmljcyAmYW1wOyBHZXJvbnRv

bG9neSBJbnRlcm5hdGlvbmFsPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+R2VyaWF0cmljcyBhbmQgR2Vyb250b2xvZ3kgSW50ZXJuYXRpb25hbDwvZnVs

bC10aXRsZT48YWJici0xPkdlcmlhdHIgR2Vyb250b2wgSW50PC9hYmJyLTE+PGFiYnItMj5HZXJp

YXRyaWNzICZhbXA7IEdlcm9udG9sb2d5IEludGVybmF0aW9uYWw8L2FiYnItMj48L3BlcmlvZGlj

YWw+PHBhZ2VzPjMzMC0zMzc8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVtYmVyPjI8L251

bWJlcj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAyMSk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+SGFzaGltb3RvPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVjTnVtPjIwMjIzPC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMDIyMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMw

dCIgdGltZXN0YW1wPSIxNTMwMzU1NTM0Ij4yMDIyMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYt

dHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxh

dXRob3JzPjxhdXRob3I+SGFzaGltb3RvLCBNLjwvYXV0aG9yPjxhdXRob3I+S2F0bywgUy48L2F1

dGhvcj48YXV0aG9yPlRhbmFiZSwgWS48L2F1dGhvcj48YXV0aG9yPkthdGFrdXJhLCBNLjwvYXV0

aG9yPjxhdXRob3I+TWFtdW4sIEEuIEEuPC9hdXRob3I+PGF1dGhvcj5PaG5vLCBNLjwvYXV0aG9y

PjxhdXRob3I+ZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVz

Pjx0aXRsZT5CZW5lZmljaWFsIGVmZmVjdHMgb2YgZGlldGFyeSBkb2Nvc2FoZXhhZW5vaWMgYWNp

ZCBpbnRlcnZlbnRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGFuZCBtZW50YWwgaGVhbHRoIG9m

IHRoZSBvbGRlc3QgZWxkZXJseSBpbiBKYXBhbmVzZSBjYXJlIGZhY2lsaXRpZXMgYW5kIG51cnNp

bmcgaG9tZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+R2VyaWF0cmljcyAmYW1wOyBHZXJvbnRv

bG9neSBJbnRlcm5hdGlvbmFsPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+R2VyaWF0cmljcyBhbmQgR2Vyb250b2xvZ3kgSW50ZXJuYXRpb25hbDwvZnVs

bC10aXRsZT48YWJici0xPkdlcmlhdHIgR2Vyb250b2wgSW50PC9hYmJyLTE+PGFiYnItMj5HZXJp

YXRyaWNzICZhbXA7IEdlcm9udG9sb2d5IEludGVybmF0aW9uYWw8L2FiYnItMj48L3BlcmlvZGlj

YWw+PHBhZ2VzPjMzMC0zMzc8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVtYmVyPjI8L251

bWJlcj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (2, 21); one provided dietary advice PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXR0bGU8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MTYyODc8L1JlY051bT48RGlzcGxheVRleHQ+KDMyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE4NTQ5Ij4xNjI4Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+VHV0dGxlLCBLLiBSLjwvYXV0aG9yPjxhdXRob3I+U2h1bGVyLCBMLiBBLjwvYXV0aG9yPjxh

dXRob3I+UGFja2FyZCwgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1pbHRvbiwgSi4gRS48L2F1dGhv

cj48YXV0aG9yPkRhcmF0aGEsIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5CaWJ1cywgRC4gTS48L2F1

dGhvcj48YXV0aG9yPlNob3J0LCBSLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlR1dHRsZSxLYXRoZXJpbmUgUi4gVGhlIEhlYXJ0IEluc3RpdHV0ZSBv

ZiBTcG9rYW5lLCBTYWNyZWQgSGVhcnQgTWVkaWNhbCBDZW50ZXIsIFNwb2thbmUsIFdhc2hpbmd0

b24sIFVTQS4ga3R1dHRsZUBzaG1jLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNv

bXBhcmlzb24gb2YgbG93LWZhdCB2ZXJzdXMgTWVkaXRlcnJhbmVhbi1zdHlsZSBkaWV0YXJ5IGlu

dGVydmVudGlvbiBhZnRlciBmaXJzdCBteW9jYXJkaWFsIGluZmFyY3Rpb24gKGZyb20gVGhlIEhl

YXJ0IEluc3RpdHV0ZSBvZiBTcG9rYW5lIERpZXQgSW50ZXJ2ZW50aW9uIGFuZCBFdmFsdWF0aW9u

IFRyaWFsKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2FyZGlvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2Fy

ZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwvYWJici0xPjxhYmJyLTI+

VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0yPjxhYmJyLTM+VGhlIGFt

ZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+QW0gSiBDYXJkaW9sPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4g

Sm91cm5hbCBvZiBDYXJkaW9sb2d5PC9hYmJyLTI+PGFiYnItMz5UaGUgYW1lcmljYW4gam91cm5h

bCBvZiBjYXJkaW9sb2d5PC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTUyMy0xNTMw

PC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNv

bmZpZGVuY2UgSW50ZXJ2YWxzICpEaWV0LEZhdC1SZXN0cmljdGVkL210IFtNZXRob2RzXSAqRGll

dCxNZWRpdGVycmFuZWFuIERpc2Vhc2UtRnJlZSBTdXJ2aXZhbCBGZW1hbGUgRm9sbG93LVVwIFN0

dWRpZXMgSHVtYW5zIE1hbGUgTWlkZGxlIEFnZWQgKk15b2NhcmRpYWwgSW5mYXJjdGlvbi9kaCBb

RGlldCBUaGVyYXB5XSBNeW9jYXJkaWFsIEluZmFyY3Rpb24vZXAgW0VwaWRlbWlvbG9neV0gT2Rk

cyBSYXRpbyBSZXRyb3NwZWN0aXZlIFM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAwMDItOTE0OTwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5hbWpjYXJkLjIwMDguMDEuMDM4O0NvbXBhcmF0aXZlIFN0

dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODQ4OTkyN2h0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NDg5OTI3JmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouYW1qY2FyZC4yMDA4LjAxLjAzOCZhbXA7aXNzbj0wMDAyLTkxNDkm

YW1wO2lzYm49JmFtcDt2b2x1bWU9MTAxJmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9MTUyMyZhbXA7

cGFnZXM9MTUyMy0zMCZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29m

K0NhcmRpb2xvZ3kmYW1wO2F0aXRsZT1Db21wYXJpc29uK29mK2xvdy1mYXQrdmVyc3VzK01lZGl0

ZXJyYW5lYW4tc3R5bGUrZGlldGFyeStpbnRlcnZlbnRpb24rYWZ0ZXIrZmlyc3QrbXlvY2FyZGlh

bCtpbmZhcmN0aW9uKyUyOGZyb20rVGhlK0hlYXJ0K0luc3RpdHV0ZStvZitTcG9rYW5lK0RpZXQr

SW50ZXJ2ZW50aW9uK2FuZCtFdmFsdWF0aW9uK1RyaWFsJTI5LiZhbXA7YXVsYXN0PVR1dHRsZTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXR0bGU8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MTYyODc8L1JlY051bT48RGlzcGxheVRleHQ+KDMyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE4NTQ5Ij4xNjI4Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+VHV0dGxlLCBLLiBSLjwvYXV0aG9yPjxhdXRob3I+U2h1bGVyLCBMLiBBLjwvYXV0aG9yPjxh

dXRob3I+UGFja2FyZCwgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1pbHRvbiwgSi4gRS48L2F1dGhv

cj48YXV0aG9yPkRhcmF0aGEsIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5CaWJ1cywgRC4gTS48L2F1

dGhvcj48YXV0aG9yPlNob3J0LCBSLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlR1dHRsZSxLYXRoZXJpbmUgUi4gVGhlIEhlYXJ0IEluc3RpdHV0ZSBv

ZiBTcG9rYW5lLCBTYWNyZWQgSGVhcnQgTWVkaWNhbCBDZW50ZXIsIFNwb2thbmUsIFdhc2hpbmd0

b24sIFVTQS4ga3R1dHRsZUBzaG1jLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNv

bXBhcmlzb24gb2YgbG93LWZhdCB2ZXJzdXMgTWVkaXRlcnJhbmVhbi1zdHlsZSBkaWV0YXJ5IGlu

dGVydmVudGlvbiBhZnRlciBmaXJzdCBteW9jYXJkaWFsIGluZmFyY3Rpb24gKGZyb20gVGhlIEhl

YXJ0IEluc3RpdHV0ZSBvZiBTcG9rYW5lIERpZXQgSW50ZXJ2ZW50aW9uIGFuZCBFdmFsdWF0aW9u

IFRyaWFsKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2FyZGlvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2Fy

ZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwvYWJici0xPjxhYmJyLTI+

VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0yPjxhYmJyLTM+VGhlIGFt

ZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+QW0gSiBDYXJkaW9sPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4g

Sm91cm5hbCBvZiBDYXJkaW9sb2d5PC9hYmJyLTI+PGFiYnItMz5UaGUgYW1lcmljYW4gam91cm5h

bCBvZiBjYXJkaW9sb2d5PC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTUyMy0xNTMw

PC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNv

bmZpZGVuY2UgSW50ZXJ2YWxzICpEaWV0LEZhdC1SZXN0cmljdGVkL210IFtNZXRob2RzXSAqRGll

dCxNZWRpdGVycmFuZWFuIERpc2Vhc2UtRnJlZSBTdXJ2aXZhbCBGZW1hbGUgRm9sbG93LVVwIFN0

dWRpZXMgSHVtYW5zIE1hbGUgTWlkZGxlIEFnZWQgKk15b2NhcmRpYWwgSW5mYXJjdGlvbi9kaCBb

RGlldCBUaGVyYXB5XSBNeW9jYXJkaWFsIEluZmFyY3Rpb24vZXAgW0VwaWRlbWlvbG9neV0gT2Rk

cyBSYXRpbyBSZXRyb3NwZWN0aXZlIFM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAwMDItOTE0OTwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5hbWpjYXJkLjIwMDguMDEuMDM4O0NvbXBhcmF0aXZlIFN0

dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODQ4OTkyN2h0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NDg5OTI3JmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouYW1qY2FyZC4yMDA4LjAxLjAzOCZhbXA7aXNzbj0wMDAyLTkxNDkm

YW1wO2lzYm49JmFtcDt2b2x1bWU9MTAxJmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9MTUyMyZhbXA7

cGFnZXM9MTUyMy0zMCZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29m

K0NhcmRpb2xvZ3kmYW1wO2F0aXRsZT1Db21wYXJpc29uK29mK2xvdy1mYXQrdmVyc3VzK01lZGl0

ZXJyYW5lYW4tc3R5bGUrZGlldGFyeStpbnRlcnZlbnRpb24rYWZ0ZXIrZmlyc3QrbXlvY2FyZGlh

bCtpbmZhcmN0aW9uKyUyOGZyb20rVGhlK0hlYXJ0K0luc3RpdHV0ZStvZitTcG9rYW5lK0RpZXQr

SW50ZXJ2ZW50aW9uK2FuZCtFdmFsdWF0aW9uK1RyaWFsJTI5LiZhbXA7YXVsYXN0PVR1dHRsZTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (32); and one a combination.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZWxsYXM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

ZWNOdW0+MTY2MTc8L1JlY051bT48RGlzcGxheVRleHQ+KDcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjE2NjE3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTg3NDIiPjE2NjE3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5WZWxsYXMsIEIuPC9hdXRob3I+PGF1dGhvcj5DYXJyaWUsIEkuPC9hdXRob3I+PGF1dGhvcj5H

dXlvbm5ldCwgUy48L2F1dGhvcj48YXV0aG9yPlRvdWNob24sIEouPC9hdXRob3I+PGF1dGhvcj5E

YW50b2luZSwgVC48L2F1dGhvcj48YXV0aG9yPkRhcnRpZ3VlcywgSi4gRi48L2F1dGhvcj48YXV0

aG9yPkN1ZmksIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5Cb3JkZXMsIFMuPC9hdXRob3I+PGF1dGhv

cj5HYXNuaWVyLCBZLjwvYXV0aG9yPjxhdXRob3I+Um9iZXJ0LCBQLjwvYXV0aG9yPjxhdXRob3I+

Qm9yaWVzLCBMLjwvYXV0aG9yPjxhdXRob3I+Um91YXVkLCBPLjwvYXV0aG9yPjxhdXRob3I+RGVz

Y2xhdXgsIEYuPC9hdXRob3I+PGF1dGhvcj5TdWRyZXMsIEsuPC9hdXRob3I+PGF1dGhvcj5Cb25u

ZWZveSwgTS48L2F1dGhvcj48YXV0aG9yPlBlc2NlLCBBLjwvYXV0aG9yPjxhdXRob3I+Rm91Z2Vy

ZSwgQi48L2F1dGhvcj48YXV0aG9yPkRlbHJpZXUsIEouPC9hdXRob3I+PGF1dGhvcj5GYWlzYW50

LCBDLjwvYXV0aG9yPjxhdXRob3I+TGFsYSwgRi48L2F1dGhvcj48YXV0aG9yPkR1cHV5LCBDLjwv

YXV0aG9yPjxhdXRob3I+Q2FudGV0LCBDLjwvYXV0aG9yPjxhdXRob3I+Q29sZXksIE4uPC9hdXRo

b3I+PGF1dGhvcj5CZWxsZXZpbGxlLCBTLjwvYXV0aG9yPjxhdXRob3I+V2lsbGlzLCBTLiBMLjwv

YXV0aG9yPjxhdXRob3I+V2VpbmVyLCBNLiBXLjwvYXV0aG9yPjxhdXRob3I+SmVhbiBPdXNzZXQs

IFAuPC9hdXRob3I+PGF1dGhvcj5BbmRyaWV1LCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPihWZWxsYXMpIElOU0VSTSBVTVIgMTAyNywgVG91bG91c2Us

IEZyYW5jZSAoVmVsbGFzLCBHdXlvbm5ldCwgQ29sZXkpIFVuaXZlcnNpdHkgb2YgVG91bG91c2Ug

SUlJLCBUb3Vsb3VzZSwgRnJhbmNlIChWZWxsYXMsIExhbGEsIEplYW4gT3Vzc2V0KSBDSFUgVG91

bG91c2UsIFRvdWxvdXNlLCBGcmFuY2UgKENhcnJpZSwgR3V5b25uZXQsIEZvdWdlcmUsIEZhaXNh

bnQsIER1cHV5LCBDYW50ZXQsIEFuZHJpZXUpIFRvdWxvdXNlRnJhbmNlIChHdXlvbm5ldCwgRHVw

dXksIENhbnRldCwgQ29sZXkpIElOU0VSTSBVTVIgMTAyNywgRnJhbmNlIChUb3VjaG9uKSBDSFUg

TW9udHBlbGxpZXIsIE1vbnRwZWxsaWVyLCBGcmFuY2UgKERhbnRvaW5lKSBDSFUgTGltb2dlcywg

TGltb2dlcywgRnJhbmNlIChEYXJ0aWd1ZXMpIElOU0VSTSBVODk3LCBCb3JkZWF1eCwgRnJhbmNl

IChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHksIEJvcmRlYXV4LCBGcmFuY2UgKERhcnRp

Z3VlcykgTWVtb3J5IGNvbnN1bHRhdGlvbiwgQ0hVIEJvcmRlYXV4LCBCb3JkZWF1eCwgRnJhbmNl

IChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEJvcmRlYXV4LCBGcmFu

Y2UgKEN1ZmkpIENIIENhc3RyZXMsIENhc3RyZXMsIEZyYW5jZSAoQm9yZGVzLCBHYXNuaWVyKSBD

SCBUYXJiZXMsIFRhcmJlcywgRnJhbmNlIChSb2JlcnQpIENIVSBOaWNlLCBOaWNlLCBGcmFuY2Ug

KEJvcmllcykgQ0ggRm9peCwgRm9peCwgRnJhbmNlIChSb3VhdWQpIEhvcGl0YWwgR2VuZXJhbCwg

RGlqb24sIEZyYW5jZSAoRGVzY2xhdXgpIENIIExhdmF1ciwgTGF2YXVyLCBGcmFuY2UgKFN1ZHJl

cykgQ0ggTW9udGF1YmFuLCBNb250YXViYW4sIEZyYW5jZSAoQm9ubmVmb3kpIENIVSBMeW9uIFNV

RCwgTHlvbiwgRnJhbmNlIChQZXNjZSkgQ0ggUHJpbmNlc3NlIEdyYWNlLCBNb25hY28sIE1vbmFj

byAoRGVscmlldSkgSW5zdGl0dXRlIG9mIEFnaW5nLCBVbml2ZXJzaXR5IEhvc3BpdGFsIFRvdWxv

dXNlLCBUb3Vsb3VzZSwgRnJhbmNlIChCZWxsZXZpbGxlKSBJbnN0aXR1dCBVbml2ZXJzaXRhaXJl

IERlIEdlcmlhdHJpZSBEZSBNb250cmVhbCwgTW9udHJlYWwsIFFDLCBDYW5hZGEgKEJlbGxldmls

bGUpIFVuaXZlcnNpdGUgRGUgTW9udHJlYWwsIE1vbnRyZWFsLCBRQywgQ2FuYWRhIChXaWxsaXMp

IEluZGlhbmEgVW5pdmVyc2l0eSwgSW5kaWFuYXBvbGlzLCBJTiwgVW5pdGVkIFN0YXRlcyAoV2Vp

bmVyKSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEgU2FuIEZyYW5jaXNjbywgU2FuIEZyYW5jaXNj

bywgQ0EsIFVuaXRlZCBTdGF0ZXMgKEFuZHJpZXUpIElOU0VSTSBVTVIgMTAyNywgUGF1bCBTYWJh

dGllciBVbml2ZXJzaXR5LCBUb3Vsb3VzZSwgRnJhbmNlIEIuIFZlbGxhcywgSU5TRVJNIFVNUiAx

MDI3LCBUb3Vsb3VzZSwgRnJhbmNlLiBFLW1haWw6IHZlbGxhcy5iQGNodS10b3Vsb3VzZS5mcjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1BUFQgKG11bHRpLWRvbWFpbiBBbHpoZWltZXIm

YXBvcztzIHByZXZlbnRpb24gdHJpYWwpOiBSZXN1bHRzIGF0IDM2IG1vbnRoczwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5BbHpoZWltZXImYXBvcztzIGFuZCBEZW1lbnRpYTwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFsemhlaW1lciZhcG9zO3MgJmFt

cDsgRGVtZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbHpoZWltZXImYXBvcztzIGRlbWVudDwv

YWJici0xPjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L2FiYnItMj48YWJi

ci0zPkFsemhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4z

MzE8L3BhZ2VzPjx2b2x1bWU+MSk8L3ZvbHVtZT48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxF

PC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPnByZXZlbnRpb24gc3R1ZHkgaHVt

YW4gY29nbml0aW9uIG1lbW9yeSBzYWZldHkgZGlnaXQgc3ltYm9sIHN1YnN0aXR1dGlvbiB0ZXN0

IGNsaW5pY2FsIHRyaWFsIGhvc3BpdGFsIHRyYWlsIG1ha2luZyB0ZXN0IG51dHJpdGlvbiBwaHlz

aWNhbCBhY3Rpdml0eSBvdXRwYXRpZW50IGFnZWQgc3VwcGxlbWVudGF0aW9uIGFkdWx0IFdlY2hz

bGVyIGFkdWx0IGludGVsbGlnZW5jZSBzY2FsZSBNaW5pIE1lbnRhbCBTdGF0ZSBFeGFtaW5hdGlv

biBvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVz

Pjxpc2JuPjE1NTItNTI2MDwvaXNibj48d29yay10eXBlPkNvbmZlcmVuY2UgQWJzdHJhY3Q8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9v

dmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFt

cDtEPWVtZWQxMyZhbXA7QU49NzIxMjQ1NzFodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/

c2lkPU9WSUQ6ZW1iYXNlJmFtcDtpZD1wbWlkOiZhbXA7aWQ9ZG9pOiZhbXA7aXNzbj0xNTUyLTUy

NjAmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTEmYW1wO2lzc3VlPTcrU1VQUEwuKzEmYW1wO3NwYWdl

PVAzMzEmYW1wO3BhZ2VzPVAzMzEmYW1wO2RhdGU9MjAxNSZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3

cythbmQrRGVtZW50aWEmYW1wO2F0aXRsZT1NQVBUKyUyOG11bHRpLWRvbWFpbitBbHpoZWltZXIl

MjdzK3ByZXZlbnRpb24rdHJpYWwlMjklM0ErUmVzdWx0cythdCszNittb250aHMmYW1wO2F1bGFz

dD1WZWxsYXM8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZWxsYXM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

ZWNOdW0+MTY2MTc8L1JlY051bT48RGlzcGxheVRleHQ+KDcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjE2NjE3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTg3NDIiPjE2NjE3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5WZWxsYXMsIEIuPC9hdXRob3I+PGF1dGhvcj5DYXJyaWUsIEkuPC9hdXRob3I+PGF1dGhvcj5H

dXlvbm5ldCwgUy48L2F1dGhvcj48YXV0aG9yPlRvdWNob24sIEouPC9hdXRob3I+PGF1dGhvcj5E

YW50b2luZSwgVC48L2F1dGhvcj48YXV0aG9yPkRhcnRpZ3VlcywgSi4gRi48L2F1dGhvcj48YXV0

aG9yPkN1ZmksIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5Cb3JkZXMsIFMuPC9hdXRob3I+PGF1dGhv

cj5HYXNuaWVyLCBZLjwvYXV0aG9yPjxhdXRob3I+Um9iZXJ0LCBQLjwvYXV0aG9yPjxhdXRob3I+

Qm9yaWVzLCBMLjwvYXV0aG9yPjxhdXRob3I+Um91YXVkLCBPLjwvYXV0aG9yPjxhdXRob3I+RGVz

Y2xhdXgsIEYuPC9hdXRob3I+PGF1dGhvcj5TdWRyZXMsIEsuPC9hdXRob3I+PGF1dGhvcj5Cb25u

ZWZveSwgTS48L2F1dGhvcj48YXV0aG9yPlBlc2NlLCBBLjwvYXV0aG9yPjxhdXRob3I+Rm91Z2Vy

ZSwgQi48L2F1dGhvcj48YXV0aG9yPkRlbHJpZXUsIEouPC9hdXRob3I+PGF1dGhvcj5GYWlzYW50

LCBDLjwvYXV0aG9yPjxhdXRob3I+TGFsYSwgRi48L2F1dGhvcj48YXV0aG9yPkR1cHV5LCBDLjwv

YXV0aG9yPjxhdXRob3I+Q2FudGV0LCBDLjwvYXV0aG9yPjxhdXRob3I+Q29sZXksIE4uPC9hdXRo

b3I+PGF1dGhvcj5CZWxsZXZpbGxlLCBTLjwvYXV0aG9yPjxhdXRob3I+V2lsbGlzLCBTLiBMLjwv

YXV0aG9yPjxhdXRob3I+V2VpbmVyLCBNLiBXLjwvYXV0aG9yPjxhdXRob3I+SmVhbiBPdXNzZXQs

IFAuPC9hdXRob3I+PGF1dGhvcj5BbmRyaWV1LCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPihWZWxsYXMpIElOU0VSTSBVTVIgMTAyNywgVG91bG91c2Us

IEZyYW5jZSAoVmVsbGFzLCBHdXlvbm5ldCwgQ29sZXkpIFVuaXZlcnNpdHkgb2YgVG91bG91c2Ug

SUlJLCBUb3Vsb3VzZSwgRnJhbmNlIChWZWxsYXMsIExhbGEsIEplYW4gT3Vzc2V0KSBDSFUgVG91

bG91c2UsIFRvdWxvdXNlLCBGcmFuY2UgKENhcnJpZSwgR3V5b25uZXQsIEZvdWdlcmUsIEZhaXNh

bnQsIER1cHV5LCBDYW50ZXQsIEFuZHJpZXUpIFRvdWxvdXNlRnJhbmNlIChHdXlvbm5ldCwgRHVw

dXksIENhbnRldCwgQ29sZXkpIElOU0VSTSBVTVIgMTAyNywgRnJhbmNlIChUb3VjaG9uKSBDSFUg

TW9udHBlbGxpZXIsIE1vbnRwZWxsaWVyLCBGcmFuY2UgKERhbnRvaW5lKSBDSFUgTGltb2dlcywg

TGltb2dlcywgRnJhbmNlIChEYXJ0aWd1ZXMpIElOU0VSTSBVODk3LCBCb3JkZWF1eCwgRnJhbmNl

IChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHksIEJvcmRlYXV4LCBGcmFuY2UgKERhcnRp

Z3VlcykgTWVtb3J5IGNvbnN1bHRhdGlvbiwgQ0hVIEJvcmRlYXV4LCBCb3JkZWF1eCwgRnJhbmNl

IChEYXJ0aWd1ZXMpIEJvcmRlYXV4IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEJvcmRlYXV4LCBGcmFu

Y2UgKEN1ZmkpIENIIENhc3RyZXMsIENhc3RyZXMsIEZyYW5jZSAoQm9yZGVzLCBHYXNuaWVyKSBD

SCBUYXJiZXMsIFRhcmJlcywgRnJhbmNlIChSb2JlcnQpIENIVSBOaWNlLCBOaWNlLCBGcmFuY2Ug

KEJvcmllcykgQ0ggRm9peCwgRm9peCwgRnJhbmNlIChSb3VhdWQpIEhvcGl0YWwgR2VuZXJhbCwg

RGlqb24sIEZyYW5jZSAoRGVzY2xhdXgpIENIIExhdmF1ciwgTGF2YXVyLCBGcmFuY2UgKFN1ZHJl

cykgQ0ggTW9udGF1YmFuLCBNb250YXViYW4sIEZyYW5jZSAoQm9ubmVmb3kpIENIVSBMeW9uIFNV

RCwgTHlvbiwgRnJhbmNlIChQZXNjZSkgQ0ggUHJpbmNlc3NlIEdyYWNlLCBNb25hY28sIE1vbmFj

byAoRGVscmlldSkgSW5zdGl0dXRlIG9mIEFnaW5nLCBVbml2ZXJzaXR5IEhvc3BpdGFsIFRvdWxv

dXNlLCBUb3Vsb3VzZSwgRnJhbmNlIChCZWxsZXZpbGxlKSBJbnN0aXR1dCBVbml2ZXJzaXRhaXJl

IERlIEdlcmlhdHJpZSBEZSBNb250cmVhbCwgTW9udHJlYWwsIFFDLCBDYW5hZGEgKEJlbGxldmls

bGUpIFVuaXZlcnNpdGUgRGUgTW9udHJlYWwsIE1vbnRyZWFsLCBRQywgQ2FuYWRhIChXaWxsaXMp

IEluZGlhbmEgVW5pdmVyc2l0eSwgSW5kaWFuYXBvbGlzLCBJTiwgVW5pdGVkIFN0YXRlcyAoV2Vp

bmVyKSBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEgU2FuIEZyYW5jaXNjbywgU2FuIEZyYW5jaXNj

bywgQ0EsIFVuaXRlZCBTdGF0ZXMgKEFuZHJpZXUpIElOU0VSTSBVTVIgMTAyNywgUGF1bCBTYWJh

dGllciBVbml2ZXJzaXR5LCBUb3Vsb3VzZSwgRnJhbmNlIEIuIFZlbGxhcywgSU5TRVJNIFVNUiAx

MDI3LCBUb3Vsb3VzZSwgRnJhbmNlLiBFLW1haWw6IHZlbGxhcy5iQGNodS10b3Vsb3VzZS5mcjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk1BUFQgKG11bHRpLWRvbWFpbiBBbHpoZWltZXIm

YXBvcztzIHByZXZlbnRpb24gdHJpYWwpOiBSZXN1bHRzIGF0IDM2IG1vbnRoczwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5BbHpoZWltZXImYXBvcztzIGFuZCBEZW1lbnRpYTwvc2Vjb25kYXJ5LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFsemhlaW1lciZhcG9zO3MgJmFt

cDsgRGVtZW50aWE8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbHpoZWltZXImYXBvcztzIGRlbWVudDwv

YWJici0xPjxhYmJyLTI+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L2FiYnItMj48YWJi

ci0zPkFsemhlaW1lcnMgYW5kIERlbWVudGlhPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4z

MzE8L3BhZ2VzPjx2b2x1bWU+MSk8L3ZvbHVtZT48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxF

PC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPnByZXZlbnRpb24gc3R1ZHkgaHVt

YW4gY29nbml0aW9uIG1lbW9yeSBzYWZldHkgZGlnaXQgc3ltYm9sIHN1YnN0aXR1dGlvbiB0ZXN0

IGNsaW5pY2FsIHRyaWFsIGhvc3BpdGFsIHRyYWlsIG1ha2luZyB0ZXN0IG51dHJpdGlvbiBwaHlz

aWNhbCBhY3Rpdml0eSBvdXRwYXRpZW50IGFnZWQgc3VwcGxlbWVudGF0aW9uIGFkdWx0IFdlY2hz

bGVyIGFkdWx0IGludGVsbGlnZW5jZSBzY2FsZSBNaW5pIE1lbnRhbCBTdGF0ZSBFeGFtaW5hdGlv

biBvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVz

Pjxpc2JuPjE1NTItNTI2MDwvaXNibj48d29yay10eXBlPkNvbmZlcmVuY2UgQWJzdHJhY3Q8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9v

dmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFt

cDtEPWVtZWQxMyZhbXA7QU49NzIxMjQ1NzFodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/

c2lkPU9WSUQ6ZW1iYXNlJmFtcDtpZD1wbWlkOiZhbXA7aWQ9ZG9pOiZhbXA7aXNzbj0xNTUyLTUy

NjAmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTEmYW1wO2lzc3VlPTcrU1VQUEwuKzEmYW1wO3NwYWdl

PVAzMzEmYW1wO3BhZ2VzPVAzMzEmYW1wO2RhdGU9MjAxNSZhbXA7dGl0bGU9QWx6aGVpbWVyJTI3

cythbmQrRGVtZW50aWEmYW1wO2F0aXRsZT1NQVBUKyUyOG11bHRpLWRvbWFpbitBbHpoZWltZXIl

MjdzK3ByZXZlbnRpb24rdHJpYWwlMjklM0ErUmVzdWx0cythdCszNittb250aHMmYW1wO2F1bGFz

dD1WZWxsYXM8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE.DATA (7) The ALA trial provided enriched margarine PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxhdXRo

b3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwgR3Jv

dXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3JvbWhv

dXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZlcnNp

dHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zhc2N1

bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJi

ci0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+VGhl

IE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8

L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2Fi

YnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+

PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwvdm9s

dW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBDYXJk

aW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIgRGlz

ZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50cyBE

b2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVub2lj

IEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBUaGVy

YXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48

aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDU2

L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRy

aWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6Ly9z

ZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwOTI5

MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00Nzkz

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUmYW1w

O3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91cm5h

bCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFzY3Vs

YXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9taG91

dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxhdXRo

b3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwgR3Jv

dXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3JvbWhv

dXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZlcnNp

dHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zhc2N1

bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJi

ci0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+VGhl

IE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8

L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2Fi

YnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+

PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwvdm9s

dW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBDYXJk

aW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIgRGlz

ZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50cyBE

b2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVub2lj

IEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBUaGVy

YXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48

aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDU2

L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRy

aWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6Ly9z

ZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwOTI5

MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00Nzkz

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUmYW1w

O3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91cm5h

bCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFzY3Vs

YXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9taG91

dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (2), and the PUFA trial dietary advice plus nuts. ADDIN EN.CITE <EndNote><Cite><Author>Estruch</Author><Year>2018</Year><RecNum>18084</RecNum><DisplayText>(35)</DisplayText><record><rec-number>18084</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530303952">18084</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Estruch, R.</author><author>Ros, E.</author><author>Salas-Salvadó, J.</author><author>Covas, M.</author><author>Corella, D.</author><author>Arós F et, a l</author></authors></contributors><titles><title>Retraction and republication: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368:1279-90</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N Engl J Med</abbr-1><abbr-2>NEJM</abbr-2><abbr-3>The New England Journal of Medicine</abbr-3></periodical><pages>25-25</pages><volume>378</volume><dates><year>2018</year></dates><urls></urls></record></Cite></EndNote>(35) LCn3 doses ranged from 300mg/d PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MTU2ODU8L1JlY051bT48RGlzcGxheVRleHQ+KDMxKTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNTY4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4MjE1Ij4xNTY4NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VGFqYWxpemFkZWtob29iLCBZLjwvYXV0aG9yPjxhdXRob3I+U2hhcmlmaSwg

Ri48L2F1dGhvcj48YXV0aG9yPkZha2hyemFkZWgsIEguPC9hdXRob3I+PGF1dGhvcj5NaXJhcmVm

aW4sIE0uPC9hdXRob3I+PGF1dGhvcj5HaGFkZXJwYW5haGksIE0uPC9hdXRob3I+PGF1dGhvcj5C

YWRhbWNoaXphZGUsIFouPC9hdXRob3I+PGF1dGhvcj5BemltaXBvdXIsIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGFqYWxpemFkZWtob29iLFlhc2Vy

LiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtIFJlc2VhcmNoIENlbnRlciwgVGVocmFuIFVu

aXZlcnNpdHkgb2YgTWVkaWNhbCBTY2llbmNlcywgNXRoIGZsb29yLCBEciBTaGFyZWVhdGkgSG9z

cGl0YWwsIE5vcnRoIEthcmVnYXIgQXZlbnVlLCBUZWhyYW4sIElyYW48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0IG9mIGxvdy1kb3NlIG9tZWdhIDMgZmF0dHkgYWNpZHMg

b24gdGhlIHRyZWF0bWVudCBvZiBtaWxkIHRvIG1vZGVyYXRlIGRlcHJlc3Npb24gaW4gdGhlIGVs

ZGVybHk6IGEgZG91YmxlLWJsaW5kLCByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRy

eSAmYW1wOyBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0cnkgJmFt

cDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFyY2ggUHN5

Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNoaXZlcyBv

ZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNo

aWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy

IEFyY2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBB

cmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MzktNTQ5PC9wYWdlcz48dm9sdW1lPjI2MTwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFudGlkZXBy

ZXNzaXZlIEFnZW50cy90dSBbVGhlcmFwZXV0aWMgVXNlXSAqRGVwcmVzc2lvbi9kdCBbRHJ1ZyBU

aGVyYXB5XSBEaWV0IERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBIeXBlcnNlbnNpdGl2aXR5IEZh

dHR5IEFjaWRzLE9tZWdhLTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkZhdHR5IEFjaWRzLE9tZWdh

LTMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRmVtYWxlIEZpc2ggT2lscy9hZCBbQWRtaW5pPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PC9kYXRlcz48aXNibj4xNDMz

LTg0OTE8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MwMDQwNi0w

MTEtMDE5MS05O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTMxODQ1Mmh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMzE4NDUy

JmFtcDtpZD1kb2k6MTAuMTAwNyUyRnMwMDQwNi0wMTEtMDE5MS05JmFtcDtpc3NuPTA5NDAtMTMz

NCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNjEmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTUzOSZhbXA7

cGFnZXM9NTM5LTQ5JmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUV1cm9wZWFuK0FyY2hpdmVzK29m

K1BzeWNoaWF0cnkrJTI2K0NsaW5pY2FsK05ldXJvc2NpZW5jZSZhbXA7YXRpdGxlPVRoZStlZmZl

Y3Qrb2YrbG93LWRvc2Urb21lZ2ErMytmYXR0eSthY2lkcytvbit0aGUrdHJlYXRtZW50K29mK21p

bGQrdG8rbW9kZXJhdGUrZGVwcmVzc2lvbitpbit0aGUrZWxkZXJseSUzQSthK2RvdWJsZS1ibGlu

ZCUyQytyYW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCtzdHVkeS4mYW1wO2F1bGFzdD1U

YWphbGl6YWRla2hvb2I8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MTU2ODU8L1JlY051bT48RGlzcGxheVRleHQ+KDMxKTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNTY4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4MjE1Ij4xNTY4NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VGFqYWxpemFkZWtob29iLCBZLjwvYXV0aG9yPjxhdXRob3I+U2hhcmlmaSwg

Ri48L2F1dGhvcj48YXV0aG9yPkZha2hyemFkZWgsIEguPC9hdXRob3I+PGF1dGhvcj5NaXJhcmVm

aW4sIE0uPC9hdXRob3I+PGF1dGhvcj5HaGFkZXJwYW5haGksIE0uPC9hdXRob3I+PGF1dGhvcj5C

YWRhbWNoaXphZGUsIFouPC9hdXRob3I+PGF1dGhvcj5BemltaXBvdXIsIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGFqYWxpemFkZWtob29iLFlhc2Vy

LiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtIFJlc2VhcmNoIENlbnRlciwgVGVocmFuIFVu

aXZlcnNpdHkgb2YgTWVkaWNhbCBTY2llbmNlcywgNXRoIGZsb29yLCBEciBTaGFyZWVhdGkgSG9z

cGl0YWwsIE5vcnRoIEthcmVnYXIgQXZlbnVlLCBUZWhyYW4sIElyYW48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0IG9mIGxvdy1kb3NlIG9tZWdhIDMgZmF0dHkgYWNpZHMg

b24gdGhlIHRyZWF0bWVudCBvZiBtaWxkIHRvIG1vZGVyYXRlIGRlcHJlc3Npb24gaW4gdGhlIGVs

ZGVybHk6IGEgZG91YmxlLWJsaW5kLCByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRy

eSAmYW1wOyBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0cnkgJmFt

cDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFyY2ggUHN5

Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNoaXZlcyBv

ZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNo

aWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy

IEFyY2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBB

cmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MzktNTQ5PC9wYWdlcz48dm9sdW1lPjI2MTwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFudGlkZXBy

ZXNzaXZlIEFnZW50cy90dSBbVGhlcmFwZXV0aWMgVXNlXSAqRGVwcmVzc2lvbi9kdCBbRHJ1ZyBU

aGVyYXB5XSBEaWV0IERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBIeXBlcnNlbnNpdGl2aXR5IEZh

dHR5IEFjaWRzLE9tZWdhLTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkZhdHR5IEFjaWRzLE9tZWdh

LTMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRmVtYWxlIEZpc2ggT2lscy9hZCBbQWRtaW5pPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PC9kYXRlcz48aXNibj4xNDMz

LTg0OTE8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MwMDQwNi0w

MTEtMDE5MS05O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTMxODQ1Mmh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMzE4NDUy

JmFtcDtpZD1kb2k6MTAuMTAwNyUyRnMwMDQwNi0wMTEtMDE5MS05JmFtcDtpc3NuPTA5NDAtMTMz

NCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNjEmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTUzOSZhbXA7

cGFnZXM9NTM5LTQ5JmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUV1cm9wZWFuK0FyY2hpdmVzK29m

K1BzeWNoaWF0cnkrJTI2K0NsaW5pY2FsK05ldXJvc2NpZW5jZSZhbXA7YXRpdGxlPVRoZStlZmZl

Y3Qrb2YrbG93LWRvc2Urb21lZ2ErMytmYXR0eSthY2lkcytvbit0aGUrdHJlYXRtZW50K29mK21p

bGQrdG8rbW9kZXJhdGUrZGVwcmVzc2lvbitpbit0aGUrZWxkZXJseSUzQSthK2RvdWJsZS1ibGlu

ZCUyQytyYW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCtzdHVkeS4mYW1wO2F1bGFzdD1U

YWphbGl6YWRla2hvb2I8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (31) to 3360mg/d EPA+DHA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmF0dDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

Y051bT4xMjg0OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEyODQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY1ODEiPjEyODQ5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5QcmF0dCwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlJlaWZmZWwsIEouIEEuPC9hdXRob3I+PGF1

dGhvcj5FbGxlbmJvZ2VuLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+TmFjY2FyZWxsaSwgRy4gVi48

L2F1dGhvcj48YXV0aG9yPktvd2V5LCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPlByYXR0LENyYWlnIE0uIE1ldGhvZGlzdCBEZUJha2V5IEhlYXJ0

ICZhbXA7IFZhc2N1bGFyIENlbnRlciwgNjU2NSBGYW5uaW4gU3RyZWV0LCBGMTAwMSwgSG91c3Rv

biwgVFggNzcwMzAsIFVTQS4gY3ByYXR0QHRtaHMub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+RWZmaWNhY3kgYW5kIHNhZmV0eSBvZiBwcmVzY3JpcHRpb24gb21lZ2EtMy1hY2lkIGV0

aHlsIGVzdGVycyBmb3IgdGhlIHByZXZlbnRpb24gb2YgcmVjdXJyZW50IHN5bXB0b21hdGljIGF0

cmlhbCBmaWJyaWxsYXRpb246IGEgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

QW0gSGVhcnQgSjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFt

ZXJpY2FuIEhlYXJ0IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBIZWFydCBKPC9hYmJy

LTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSGVhcnQgSm91cm5hbDwvYWJici0yPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvZnVs

bC10aXRsZT48YWJici0xPkFtIEhlYXJ0IEo8L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBI

ZWFydCBKb3VybmFsPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTYzLTE2OTwvcGFn

ZXM+PHZvbHVtZT4xNTg8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1lZGl0aW9u

Pk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gKkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkF0cmlhbCBGaWJyaWxsYXRpb24v

cGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtB

ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvdHUgW1Ro

ZXJhcGV1dGljIFVzZV0gRG91YmxlLUJsaW5kIE08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjEwOTctNjc0NDwvaXNibj48d29yay10eXBl

Pmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5haGouMjAwOS4wNS4wMjQ7UmFuZG9taXplZCBD

b250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9v

dmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFt

cDtEPW1lZDUmYW1wO0FOPTE5NjE5NjkwaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3Np

ZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTk2MTk2OTAmYW1wO2lkPWRvaToxMC4xMDE2JTJG

ai5haGouMjAwOS4wNS4wMjQmYW1wO2lzc249MDAwMi04NzAzJmFtcDtpc2JuPSZhbXA7dm9sdW1l

PTE1OCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9MTYzJmFtcDtwYWdlcz0xNjMtMTY5LmUxLTMmYW1w

O2RhdGU9MjAwOSZhbXA7dGl0bGU9QW1lcmljYW4rSGVhcnQrSm91cm5hbCZhbXA7YXRpdGxlPUVm

ZmljYWN5K2FuZCtzYWZldHkrb2YrcHJlc2NyaXB0aW9uK29tZWdhLTMtYWNpZCtldGh5bCtlc3Rl

cnMrZm9yK3RoZStwcmV2ZW50aW9uK29mK3JlY3VycmVudCtzeW1wdG9tYXRpYythdHJpYWwrZmli

cmlsbGF0aW9uJTNBK2ErcHJvc3BlY3RpdmUrc3R1ZHkuJmFtcDthdWxhc3Q9UHJhdHQ8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmF0dDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

Y051bT4xMjg0OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEyODQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY1ODEiPjEyODQ5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5QcmF0dCwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlJlaWZmZWwsIEouIEEuPC9hdXRob3I+PGF1

dGhvcj5FbGxlbmJvZ2VuLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+TmFjY2FyZWxsaSwgRy4gVi48

L2F1dGhvcj48YXV0aG9yPktvd2V5LCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPlByYXR0LENyYWlnIE0uIE1ldGhvZGlzdCBEZUJha2V5IEhlYXJ0

ICZhbXA7IFZhc2N1bGFyIENlbnRlciwgNjU2NSBGYW5uaW4gU3RyZWV0LCBGMTAwMSwgSG91c3Rv

biwgVFggNzcwMzAsIFVTQS4gY3ByYXR0QHRtaHMub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+RWZmaWNhY3kgYW5kIHNhZmV0eSBvZiBwcmVzY3JpcHRpb24gb21lZ2EtMy1hY2lkIGV0

aHlsIGVzdGVycyBmb3IgdGhlIHByZXZlbnRpb24gb2YgcmVjdXJyZW50IHN5bXB0b21hdGljIGF0

cmlhbCBmaWJyaWxsYXRpb246IGEgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

QW0gSGVhcnQgSjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFt

ZXJpY2FuIEhlYXJ0IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBIZWFydCBKPC9hYmJy

LTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSGVhcnQgSm91cm5hbDwvYWJici0yPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvZnVs

bC10aXRsZT48YWJici0xPkFtIEhlYXJ0IEo8L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBI

ZWFydCBKb3VybmFsPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTYzLTE2OTwvcGFn

ZXM+PHZvbHVtZT4xNTg8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1lZGl0aW9u

Pk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gKkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkF0cmlhbCBGaWJyaWxsYXRpb24v

cGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtB

ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvdHUgW1Ro

ZXJhcGV1dGljIFVzZV0gRG91YmxlLUJsaW5kIE08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjEwOTctNjc0NDwvaXNibj48d29yay10eXBl

Pmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5haGouMjAwOS4wNS4wMjQ7UmFuZG9taXplZCBD

b250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9v

dmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFt

cDtEPW1lZDUmYW1wO0FOPTE5NjE5NjkwaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3Np

ZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTk2MTk2OTAmYW1wO2lkPWRvaToxMC4xMDE2JTJG

ai5haGouMjAwOS4wNS4wMjQmYW1wO2lzc249MDAwMi04NzAzJmFtcDtpc2JuPSZhbXA7dm9sdW1l

PTE1OCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9MTYzJmFtcDtwYWdlcz0xNjMtMTY5LmUxLTMmYW1w

O2RhdGU9MjAwOSZhbXA7dGl0bGU9QW1lcmljYW4rSGVhcnQrSm91cm5hbCZhbXA7YXRpdGxlPUVm

ZmljYWN5K2FuZCtzYWZldHkrb2YrcHJlc2NyaXB0aW9uK29tZWdhLTMtYWNpZCtldGh5bCtlc3Rl

cnMrZm9yK3RoZStwcmV2ZW50aW9uK29mK3JlY3VycmVudCtzeW1wdG9tYXRpYythdHJpYWwrZmli

cmlsbGF0aW9uJTNBK2ErcHJvc3BlY3RpdmUrc3R1ZHkuJmFtcDthdWxhc3Q9UHJhdHQ8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (30), with 12 trial arms assessing doses of ≤1000mg/d, 13 arms >1000 to ≤2000mg/d, and seven arms doses of >2000mg/d EPA+DHA (one trial was unclear PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXR0bGU8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MTYyODc8L1JlY051bT48RGlzcGxheVRleHQ+KDMyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE4NTQ5Ij4xNjI4Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+VHV0dGxlLCBLLiBSLjwvYXV0aG9yPjxhdXRob3I+U2h1bGVyLCBMLiBBLjwvYXV0aG9yPjxh

dXRob3I+UGFja2FyZCwgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1pbHRvbiwgSi4gRS48L2F1dGhv

cj48YXV0aG9yPkRhcmF0aGEsIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5CaWJ1cywgRC4gTS48L2F1

dGhvcj48YXV0aG9yPlNob3J0LCBSLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlR1dHRsZSxLYXRoZXJpbmUgUi4gVGhlIEhlYXJ0IEluc3RpdHV0ZSBv

ZiBTcG9rYW5lLCBTYWNyZWQgSGVhcnQgTWVkaWNhbCBDZW50ZXIsIFNwb2thbmUsIFdhc2hpbmd0

b24sIFVTQS4ga3R1dHRsZUBzaG1jLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNv

bXBhcmlzb24gb2YgbG93LWZhdCB2ZXJzdXMgTWVkaXRlcnJhbmVhbi1zdHlsZSBkaWV0YXJ5IGlu

dGVydmVudGlvbiBhZnRlciBmaXJzdCBteW9jYXJkaWFsIGluZmFyY3Rpb24gKGZyb20gVGhlIEhl

YXJ0IEluc3RpdHV0ZSBvZiBTcG9rYW5lIERpZXQgSW50ZXJ2ZW50aW9uIGFuZCBFdmFsdWF0aW9u

IFRyaWFsKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2FyZGlvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2Fy

ZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwvYWJici0xPjxhYmJyLTI+

VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0yPjxhYmJyLTM+VGhlIGFt

ZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+QW0gSiBDYXJkaW9sPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4g

Sm91cm5hbCBvZiBDYXJkaW9sb2d5PC9hYmJyLTI+PGFiYnItMz5UaGUgYW1lcmljYW4gam91cm5h

bCBvZiBjYXJkaW9sb2d5PC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTUyMy0xNTMw

PC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNv

bmZpZGVuY2UgSW50ZXJ2YWxzICpEaWV0LEZhdC1SZXN0cmljdGVkL210IFtNZXRob2RzXSAqRGll

dCxNZWRpdGVycmFuZWFuIERpc2Vhc2UtRnJlZSBTdXJ2aXZhbCBGZW1hbGUgRm9sbG93LVVwIFN0

dWRpZXMgSHVtYW5zIE1hbGUgTWlkZGxlIEFnZWQgKk15b2NhcmRpYWwgSW5mYXJjdGlvbi9kaCBb

RGlldCBUaGVyYXB5XSBNeW9jYXJkaWFsIEluZmFyY3Rpb24vZXAgW0VwaWRlbWlvbG9neV0gT2Rk

cyBSYXRpbyBSZXRyb3NwZWN0aXZlIFM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAwMDItOTE0OTwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5hbWpjYXJkLjIwMDguMDEuMDM4O0NvbXBhcmF0aXZlIFN0

dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODQ4OTkyN2h0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NDg5OTI3JmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouYW1qY2FyZC4yMDA4LjAxLjAzOCZhbXA7aXNzbj0wMDAyLTkxNDkm

YW1wO2lzYm49JmFtcDt2b2x1bWU9MTAxJmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9MTUyMyZhbXA7

cGFnZXM9MTUyMy0zMCZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29m

K0NhcmRpb2xvZ3kmYW1wO2F0aXRsZT1Db21wYXJpc29uK29mK2xvdy1mYXQrdmVyc3VzK01lZGl0

ZXJyYW5lYW4tc3R5bGUrZGlldGFyeStpbnRlcnZlbnRpb24rYWZ0ZXIrZmlyc3QrbXlvY2FyZGlh

bCtpbmZhcmN0aW9uKyUyOGZyb20rVGhlK0hlYXJ0K0luc3RpdHV0ZStvZitTcG9rYW5lK0RpZXQr

SW50ZXJ2ZW50aW9uK2FuZCtFdmFsdWF0aW9uK1RyaWFsJTI5LiZhbXA7YXVsYXN0PVR1dHRsZTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXR0bGU8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MTYyODc8L1JlY051bT48RGlzcGxheVRleHQ+KDMyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE4NTQ5Ij4xNjI4Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+VHV0dGxlLCBLLiBSLjwvYXV0aG9yPjxhdXRob3I+U2h1bGVyLCBMLiBBLjwvYXV0aG9yPjxh

dXRob3I+UGFja2FyZCwgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1pbHRvbiwgSi4gRS48L2F1dGhv

cj48YXV0aG9yPkRhcmF0aGEsIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5CaWJ1cywgRC4gTS48L2F1

dGhvcj48YXV0aG9yPlNob3J0LCBSLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlR1dHRsZSxLYXRoZXJpbmUgUi4gVGhlIEhlYXJ0IEluc3RpdHV0ZSBv

ZiBTcG9rYW5lLCBTYWNyZWQgSGVhcnQgTWVkaWNhbCBDZW50ZXIsIFNwb2thbmUsIFdhc2hpbmd0

b24sIFVTQS4ga3R1dHRsZUBzaG1jLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNv

bXBhcmlzb24gb2YgbG93LWZhdCB2ZXJzdXMgTWVkaXRlcnJhbmVhbi1zdHlsZSBkaWV0YXJ5IGlu

dGVydmVudGlvbiBhZnRlciBmaXJzdCBteW9jYXJkaWFsIGluZmFyY3Rpb24gKGZyb20gVGhlIEhl

YXJ0IEluc3RpdHV0ZSBvZiBTcG9rYW5lIERpZXQgSW50ZXJ2ZW50aW9uIGFuZCBFdmFsdWF0aW9u

IFRyaWFsKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2FyZGlvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2Fy

ZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwvYWJici0xPjxhYmJyLTI+

VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0yPjxhYmJyLTM+VGhlIGFt

ZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+QW0gSiBDYXJkaW9sPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4g

Sm91cm5hbCBvZiBDYXJkaW9sb2d5PC9hYmJyLTI+PGFiYnItMz5UaGUgYW1lcmljYW4gam91cm5h

bCBvZiBjYXJkaW9sb2d5PC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTUyMy0xNTMw

PC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNv

bmZpZGVuY2UgSW50ZXJ2YWxzICpEaWV0LEZhdC1SZXN0cmljdGVkL210IFtNZXRob2RzXSAqRGll

dCxNZWRpdGVycmFuZWFuIERpc2Vhc2UtRnJlZSBTdXJ2aXZhbCBGZW1hbGUgRm9sbG93LVVwIFN0

dWRpZXMgSHVtYW5zIE1hbGUgTWlkZGxlIEFnZWQgKk15b2NhcmRpYWwgSW5mYXJjdGlvbi9kaCBb

RGlldCBUaGVyYXB5XSBNeW9jYXJkaWFsIEluZmFyY3Rpb24vZXAgW0VwaWRlbWlvbG9neV0gT2Rk

cyBSYXRpbyBSZXRyb3NwZWN0aXZlIFM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAwMDItOTE0OTwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5hbWpjYXJkLjIwMDguMDEuMDM4O0NvbXBhcmF0aXZlIFN0

dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODQ4OTkyN2h0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NDg5OTI3JmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouYW1qY2FyZC4yMDA4LjAxLjAzOCZhbXA7aXNzbj0wMDAyLTkxNDkm

YW1wO2lzYm49JmFtcDt2b2x1bWU9MTAxJmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9MTUyMyZhbXA7

cGFnZXM9MTUyMy0zMCZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29m

K0NhcmRpb2xvZ3kmYW1wO2F0aXRsZT1Db21wYXJpc29uK29mK2xvdy1mYXQrdmVyc3VzK01lZGl0

ZXJyYW5lYW4tc3R5bGUrZGlldGFyeStpbnRlcnZlbnRpb24rYWZ0ZXIrZmlyc3QrbXlvY2FyZGlh

bCtpbmZhcmN0aW9uKyUyOGZyb20rVGhlK0hlYXJ0K0luc3RpdHV0ZStvZitTcG9rYW5lK0RpZXQr

SW50ZXJ2ZW50aW9uK2FuZCtFdmFsdWF0aW9uK1RyaWFsJTI5LiZhbXA7YXVsYXN0PVR1dHRsZTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (32), two trials included two arms with different doses PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYW4gRGUgUmVzdDwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT4xNjQ1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTIsIDI0KTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNjQ1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4NjQxIj4xNjQ1MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VmFuIERlIFJlc3QsIE8uPC9hdXRob3I+PGF1dGhvcj5HZWxlaWpuc2UsIEou

IE0uPC9hdXRob3I+PGF1dGhvcj5Lb2ssIEYuIEouPC9hdXRob3I+PGF1dGhvcj52YW4gU3RhdmVy

ZW4sIFcuIEEuPC9hdXRob3I+PGF1dGhvcj5EdWxsZW1laWplciwgQy48L2F1dGhvcj48YXV0aG9y

Pk9sZGVyaWtrZXJ0LCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+QmVla21hbiwgQS4gVC48L2F1dGhv

cj48YXV0aG9yPkRlIEdyb290LCBDLiBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPnZhbiBkZSBSZXN0LE8uIFdhZ2VuaW5nZW4gVW5pdmVyc2l0eSwgRGl2

aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBQLk8uIEJveCA4MTI5LCA2NzAwIEVWLCBXYWdlbmlu

Z2VuLCBUaGUgTmV0aGVybGFuZHMuIG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGZpc2ggb2lsIG9uIGNvZ25pdGl2ZSBwZXJmb3Jt

YW5jZSBpbiBvbGRlciBzdWJqZWN0czogYSByYW5kb21pemVkLCBjb250cm9sbGVkIHRyaWFsPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0

bGU+TmV1cm9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

TmV1cm9sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+TmV1cm9sb2d5PC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQzMC00

Mzg8L3BhZ2VzPjx2b2x1bWU+NzE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFn

ZWQgQ2Fwc3VsZXMgKkNvZ25pdGlvbiAqQ29nbml0aW9uIERpc29yZGVycy9wYyBbUHJldmVudGlv

biAmYW1wOyBDb250cm9sXSBEaWV0YXJ5IFN1cHBsZW1lbnRzIERvdWJsZS1CbGluZCBNZXRob2Qg

KkVpY29zYXBlbnRhZW5vaWMgQWNpZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSAq

RmF0dHkgQWNpZHMsVW5zYXR1cmF0ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0g

RmVtYWxlICpGaXNoIE9pbHMvYWQgW0FkbWluaXN0cmF0aW88L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjE1MjYtNjMyWDwvaXNibj48d29y

ay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEyMTIvMDEud25sLjAwMDAzMjQyNjguNDUxMzgu

ODY7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4Njc4ODI2aHR0cDovL3NmeC51Y2wuYWMu

dWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTg2Nzg4MjYmYW1wO2lk

PWRvaToxMC4xMjEyJTJGMDEud25sLjAwMDAzMjQyNjguNDUxMzguODYmYW1wO2lzc249MDAyOC0z

ODc4JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTcxJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT00MzAmYW1w

O3BhZ2VzPTQzMC04JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPU5ldXJvbG9neSZhbXA7YXRpdGxl

PUVmZmVjdCtvZitmaXNoK29pbCtvbitjb2duaXRpdmUrcGVyZm9ybWFuY2UraW4rb2xkZXIrc3Vi

amVjdHMlM0ErYStyYW5kb21pemVkJTJDK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFu

K2RlK1Jlc3Q8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRl

PjxBdXRob3I+U2lubjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT4xNDkwOTwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQ5MDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxNzc3MiI+MTQ5MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPlNpbm4sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWx0ZSwgQy4gTS48L2F1dGhv

cj48YXV0aG9yPlN0cmVldCwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkJ1Y2tsZXksIEouIEQuPC9h

dXRob3I+PGF1dGhvcj5Db2F0ZXMsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5QZXRrb3YsIEouPC9h

dXRob3I+PGF1dGhvcj5Ib3dlLCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlNpbm4sTmF0YWxpZS4gU2Nob29sIG9mIEhlYWx0aCBTY2llbmNlcywg

U2Fuc29tIEluc3RpdHV0ZSBmb3IgSGVhbHRoIFJlc2VhcmNoLCBOdXRyaXRpb25hbCBQaHlzaW9s

b2d5IFJlc2VhcmNoIENlbnRyZSwgVW5pdmVyc2l0eSBvZiBTb3V0aCBBdXN0cmFsaWEsIEdQTyBC

b3ggMjQ3MSwgQWRlbGFpZGUsIFNBIDUwMDEsIEF1c3RyYWxpYS4gbmF0YWxpZS5zaW5uQHVuaXNh

LmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIGZhdHR5

IGFjaWRzLCBFUEEgdi4gREhBLCBvbiBkZXByZXNzaXZlIHN5bXB0b21zLCBxdWFsaXR5IG9mIGxp

ZmUsIG1lbW9yeSBhbmQgZXhlY3V0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIGFkdWx0cyB3aXRoIG1p

bGQgY29nbml0aXZlIGltcGFpcm1lbnQ6IGEgNi1tb250aCByYW5kb21pc2VkIGNvbnRyb2xsZWQg

dHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlv

bjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwv

ZnVsbC10aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10

aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE2

ODItMTY5MzwvcGFnZXM+PHZvbHVtZT4xMDc8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PHJl

cHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQXVzdHJhbGlhIENvZ25pdGlvbiBEaXNvcmRlcnMv

YmwgW0Jsb29kXSAqQ29nbml0aW9uIERpc29yZGVycy9kaCBbRGlldCBUaGVyYXB5XSBDb2duaXRp

b24gRGlzb3JkZXJzL3BwIFtQaHlzaW9wYXRob2xvZ3ldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHgg

W1BzeWNob2xvZ3ldIERlcHJlc3Npb24vYmwgW0Jsb29kXSAqRGVwcmVzc2lvbi9kaCBbRGlldCBU

aGVyYXB5XSBEZXByZXNzaW9uL3BwIFtQaHlzaW9wPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMTI8L3llYXI+PC9kYXRlcz48aXNibj4xNDc1LTI2NjI8L2lzYm4+PHdvcmstdHlw

ZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE3L1MwMDA3MTE0NTExMDA0Nzg4O0NvbXBhcmF0aXZl

IFN0dWR5IE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNl

YXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7

Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMTky

OTgzNWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtp

ZD1wbWlkOjIxOTI5ODM1JmFtcDtpZD1kb2k6MTAuMTAxNyUyRlMwMDA3MTE0NTExMDA0Nzg4JmFt

cDtpc3NuPTAwMDctMTE0NSZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xMDcmYW1wO2lzc3VlPTExJmFt

cDtzcGFnZT0xNjgyJmFtcDtwYWdlcz0xNjgyLTkzJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUJy

aXRpc2grSm91cm5hbCtvZitOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3RzK29mK24tMytmYXR0

eSthY2lkcyUyQytFUEErdi4rREhBJTJDK29uK2RlcHJlc3NpdmUrc3ltcHRvbXMlMkMrcXVhbGl0

eStvZitsaWZlJTJDK21lbW9yeSthbmQrZXhlY3V0aXZlK2Z1bmN0aW9uK2luK29sZGVyK2FkdWx0

cyt3aXRoK21pbGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYSs2LW1vbnRoK3JhbmRvbWlzZWQr

Y29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1TaW5uPC91cmw+PC9yZWxhdGVkLXVybHM+PC91

cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYW4gRGUgUmVzdDwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT4xNjQ1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTIsIDI0KTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNjQ1MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4NjQxIj4xNjQ1MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VmFuIERlIFJlc3QsIE8uPC9hdXRob3I+PGF1dGhvcj5HZWxlaWpuc2UsIEou

IE0uPC9hdXRob3I+PGF1dGhvcj5Lb2ssIEYuIEouPC9hdXRob3I+PGF1dGhvcj52YW4gU3RhdmVy

ZW4sIFcuIEEuPC9hdXRob3I+PGF1dGhvcj5EdWxsZW1laWplciwgQy48L2F1dGhvcj48YXV0aG9y

Pk9sZGVyaWtrZXJ0LCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+QmVla21hbiwgQS4gVC48L2F1dGhv

cj48YXV0aG9yPkRlIEdyb290LCBDLiBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPnZhbiBkZSBSZXN0LE8uIFdhZ2VuaW5nZW4gVW5pdmVyc2l0eSwgRGl2

aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBQLk8uIEJveCA4MTI5LCA2NzAwIEVWLCBXYWdlbmlu

Z2VuLCBUaGUgTmV0aGVybGFuZHMuIG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJl

c3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGZpc2ggb2lsIG9uIGNvZ25pdGl2ZSBwZXJmb3Jt

YW5jZSBpbiBvbGRlciBzdWJqZWN0czogYSByYW5kb21pemVkLCBjb250cm9sbGVkIHRyaWFsPC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0

bGU+TmV1cm9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

TmV1cm9sb2d5PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+TmV1cm9sb2d5PC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQzMC00

Mzg8L3BhZ2VzPjx2b2x1bWU+NzE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFn

ZWQgQ2Fwc3VsZXMgKkNvZ25pdGlvbiAqQ29nbml0aW9uIERpc29yZGVycy9wYyBbUHJldmVudGlv

biAmYW1wOyBDb250cm9sXSBEaWV0YXJ5IFN1cHBsZW1lbnRzIERvdWJsZS1CbGluZCBNZXRob2Qg

KkVpY29zYXBlbnRhZW5vaWMgQWNpZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSAq

RmF0dHkgQWNpZHMsVW5zYXR1cmF0ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0g

RmVtYWxlICpGaXNoIE9pbHMvYWQgW0FkbWluaXN0cmF0aW88L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjE1MjYtNjMyWDwvaXNibj48d29y

ay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEyMTIvMDEud25sLjAwMDAzMjQyNjguNDUxMzgu

ODY7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu

IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292

aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ

QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4Njc4ODI2aHR0cDovL3NmeC51Y2wuYWMu

dWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTg2Nzg4MjYmYW1wO2lk

PWRvaToxMC4xMjEyJTJGMDEud25sLjAwMDAzMjQyNjguNDUxMzguODYmYW1wO2lzc249MDAyOC0z

ODc4JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTcxJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT00MzAmYW1w

O3BhZ2VzPTQzMC04JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPU5ldXJvbG9neSZhbXA7YXRpdGxl

PUVmZmVjdCtvZitmaXNoK29pbCtvbitjb2duaXRpdmUrcGVyZm9ybWFuY2UraW4rb2xkZXIrc3Vi

amVjdHMlM0ErYStyYW5kb21pemVkJTJDK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFu

K2RlK1Jlc3Q8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRl

PjxBdXRob3I+U2lubjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT4xNDkwOTwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQ5MDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxNzc3MiI+MTQ5MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPlNpbm4sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWx0ZSwgQy4gTS48L2F1dGhv

cj48YXV0aG9yPlN0cmVldCwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkJ1Y2tsZXksIEouIEQuPC9h

dXRob3I+PGF1dGhvcj5Db2F0ZXMsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5QZXRrb3YsIEouPC9h

dXRob3I+PGF1dGhvcj5Ib3dlLCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlNpbm4sTmF0YWxpZS4gU2Nob29sIG9mIEhlYWx0aCBTY2llbmNlcywg

U2Fuc29tIEluc3RpdHV0ZSBmb3IgSGVhbHRoIFJlc2VhcmNoLCBOdXRyaXRpb25hbCBQaHlzaW9s

b2d5IFJlc2VhcmNoIENlbnRyZSwgVW5pdmVyc2l0eSBvZiBTb3V0aCBBdXN0cmFsaWEsIEdQTyBC

b3ggMjQ3MSwgQWRlbGFpZGUsIFNBIDUwMDEsIEF1c3RyYWxpYS4gbmF0YWxpZS5zaW5uQHVuaXNh

LmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIGZhdHR5

IGFjaWRzLCBFUEEgdi4gREhBLCBvbiBkZXByZXNzaXZlIHN5bXB0b21zLCBxdWFsaXR5IG9mIGxp

ZmUsIG1lbW9yeSBhbmQgZXhlY3V0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIGFkdWx0cyB3aXRoIG1p

bGQgY29nbml0aXZlIGltcGFpcm1lbnQ6IGEgNi1tb250aCByYW5kb21pc2VkIGNvbnRyb2xsZWQg

dHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlv

bjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwv

ZnVsbC10aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10

aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE2

ODItMTY5MzwvcGFnZXM+PHZvbHVtZT4xMDc8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PHJl

cHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQXVzdHJhbGlhIENvZ25pdGlvbiBEaXNvcmRlcnMv

YmwgW0Jsb29kXSAqQ29nbml0aW9uIERpc29yZGVycy9kaCBbRGlldCBUaGVyYXB5XSBDb2duaXRp

b24gRGlzb3JkZXJzL3BwIFtQaHlzaW9wYXRob2xvZ3ldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHgg

W1BzeWNob2xvZ3ldIERlcHJlc3Npb24vYmwgW0Jsb29kXSAqRGVwcmVzc2lvbi9kaCBbRGlldCBU

aGVyYXB5XSBEZXByZXNzaW9uL3BwIFtQaHlzaW9wPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz

Pjx5ZWFyPjIwMTI8L3llYXI+PC9kYXRlcz48aXNibj4xNDc1LTI2NjI8L2lzYm4+PHdvcmstdHlw

ZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE3L1MwMDA3MTE0NTExMDA0Nzg4O0NvbXBhcmF0aXZl

IFN0dWR5IE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNl

YXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7

Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMTky

OTgzNWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtp

ZD1wbWlkOjIxOTI5ODM1JmFtcDtpZD1kb2k6MTAuMTAxNyUyRlMwMDA3MTE0NTExMDA0Nzg4JmFt

cDtpc3NuPTAwMDctMTE0NSZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xMDcmYW1wO2lzc3VlPTExJmFt

cDtzcGFnZT0xNjgyJmFtcDtwYWdlcz0xNjgyLTkzJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUJy

aXRpc2grSm91cm5hbCtvZitOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3RzK29mK24tMytmYXR0

eSthY2lkcyUyQytFUEErdi4rREhBJTJDK29uK2RlcHJlc3NpdmUrc3ltcHRvbXMlMkMrcXVhbGl0

eStvZitsaWZlJTJDK21lbW9yeSthbmQrZXhlY3V0aXZlK2Z1bmN0aW9uK2luK29sZGVyK2FkdWx0

cyt3aXRoK21pbGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYSs2LW1vbnRoK3JhbmRvbWlzZWQr

Y29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1TaW5uPC91cmw+PC9yZWxhdGVkLXVybHM+PC91

cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (12, 24)). Ratios of EPA to DHA varied, doses of EPA ranged from 96 to 2250mg/d, DHA from 120 to 1720mg/d. Seven RCTs randomised at least 1000 participants PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLTQsIDEwLCAxMywgMTUsIDM1KTwv

RGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRm

ZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48

cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y

cz48YXV0aG9ycz48YXV0aG9yPktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBF

LiBKLjwvYXV0aG9yPjxhdXRob3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxw

aGEgT21lZ2EgVHJpYWwgR3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+S3JvbWhvdXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBX

YWdlbmluZ2VuIFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5r

cm9taG91dEB3dXIubmw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNp

ZHMgYW5kIGNhcmRpb3Zhc2N1bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwv

c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2lu

ZTwvZnVsbC10aXRsZT48YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwv

YWJici0yPjxhYmJyLTM+VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnIt

Mz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpv

dXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnIt

MT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9m

IE1lZGljaW5lPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdl

cz48dm9sdW1lPjM2Mzwvdm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9u

Pk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdl

ZCw4MCBhbmQgb3ZlciBDYXJkaW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAq

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGll

dGFyeSBTdXBwbGVtZW50cyBEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0

c10gRG9jb3NhaGV4YWVub2ljIEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGlu

ZCBNZXRob2QgRHJ1ZyBUaGVyYXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw

MTA8L3llYXI+PC9kYXRlcz48aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8v

ZHguZG9pLm9yZy8xMC4xMDU2L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9t

aXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtB

Tj0yMDkyOTM0MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjIwOTI5MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMm

YW1wO2lzc249MDAyOC00NzkzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEm

YW1wO3NwYWdlPTIwMTUmYW1wO3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9

TmV3K0VuZ2xhbmQrSm91cm5hbCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lk

cythbmQrY2FyZGlvdmFzY3VsYXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4m

YW1wO2F1bGFzdD1Lcm9taG91dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVt

PjI4MzA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVp

Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0

dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hldywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMs

IFQuIEUuPC9hdXRob3I+PGF1dGhvcj5BZ3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwg

TC4gSi48L2F1dGhvcj48YXV0aG9yPkdyb2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5z

dGVpbiwgUC4gUy48L2F1dGhvcj48YXV0aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVk

eTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1p

bHkgWS4gRGl2aXNpb24gb2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMs

IENsaW5pY2FsIFRyaWFscyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwg

SW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBF

LiBUaGUgRU1NRVMgQ29ycG9yYXRpb24sIFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmly

YS4gRGl2aXNpb24gb2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENs

aW5pY2FsIFRyaWFscyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5z

dGl0dXRlcyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBO

ZXVyb2VwaWRlbWlvbG9neSBTZWN0aW9uLCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0

aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWlu

LEZyYW5jaW5lLiBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9z

O3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0

czVEZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhl

YWx0aCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUg

Q2VudGVyLCBVbml2ZXJzaXR5IG9mIFV0YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4

YW50aGluLCBvciBPdGhlciBOdXRyaWVudCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1

bmN0aW9uOiBUaGUgQVJFRFMyIFJhbmRvbWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+SkFNQTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhl

IEFtZXJpY2FuIE1lZGljYWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9h

YmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3Vy

bmFsIG9mIHRoZSBBbWVyaWNhbiBNZWRpY2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJy

LTE+SkFNQTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2

b2x1bWU+MzE0PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1Qg

SU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAg

YW5kIG92ZXIgQWxnb3JpdGhtcyBBc2NvcmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w

OyBEb3NhZ2VdICpDb2duaXRpb24gQ29udGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVy

L2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpE

b2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91

YmxlLUJsaW5kIE1ldGhvZCAqRWljb3NhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTU8L3llYXI+PC9kYXRlcz48aXNibj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRw

Oi8vZHguZG9pLm9yZy8xMC4xMDAxL2phbWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJh

bmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJh

bXVyYWw8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5v

dmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1

bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4

X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaTox

MC4xMDAxJTJGamFtYS4yMDE1Ljk2NzcmYW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7

dm9sdW1lPTMxNCZhbXA7aXNzdWU9OCZhbXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFt

cDtkYXRlPTIwMTUmYW1wO3RpdGxlPUpBTUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytG

YXR0eStBY2lkcyUyQytMdXRlaW4lMkZaZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1

cHBsZW1lbnRhdGlvbitvbitDb2duaXRpdmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21p

emVkK0NsaW5pY2FsK1RyaWFsLiZhbXA7YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hpdTwvQXV0aG9yPjxZZWFyPjIw

MDg8L1llYXI+PFJlY051bT4yODYyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yODYyPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZz

czVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTEwMDAiPjI4NjI8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNoaXUsIEMuIEMuPC9hdXRob3I+

PGF1dGhvcj5TdSwgSy4gUC48L2F1dGhvcj48YXV0aG9yPkNoZW5nLCBULiBDLjwvYXV0aG9yPjxh

dXRob3I+TGl1LCBILiBDLjwvYXV0aG9yPjxhdXRob3I+Q2hhbmcsIEMuIEouPC9hdXRob3I+PGF1

dGhvcj5EZXdleSwgTS4gRS48L2F1dGhvcj48YXV0aG9yPlN0ZXdhcnQsIFIuPC9hdXRob3I+PGF1

dGhvcj5IdWFuZywgUy4gWS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5DaGl1LENoaWgtQ2hpYW5nLiBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnksIFRhaXBl

aSBDaXR5IFBzeWNoaWF0cmljIENlbnRlciwgVGFpcGVpIENpdHkgSG9zcGl0YWwsIERlcGFydG1l

bnQgb2YgUHN5Y2hpYXRyeSwgVGFpcGVpIE1lZGljYWwgVW5pdmVyc2l0eSwgVGFpcGVpLCBUYWl3

YW48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0cyBvZiBvbWVnYS0zIGZh

dHR5IGFjaWRzIG1vbm90aGVyYXB5IGluIEFsemhlaW1lciZhcG9zO3MgZGlzZWFzZSBhbmQgbWls

ZCBjb2duaXRpdmUgaW1wYWlybWVudDogYSBwcmVsaW1pbmFyeSByYW5kb21pemVkIGRvdWJsZS1i

bGluZCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UHJv

Z3Jlc3MgaW4gTmV1cm8tUHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7IEJpb2xvZ2ljYWwgUHN5Y2hp

YXRyeTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNv

bCBCaW9sIFBzeWNoaWF0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5Qcm9ncmVzcyBpbiBOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3kgJmFtcDsgQmlvbG9naWNh

bCBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNv

bCBCaW9sIFBzeWNoaWF0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPlByb2dyZXNzIGluIE5ldXJvLVBzeWNob3BoYXJtYWNvbG9neSAmYW1wOyBCaW9s

b2dpY2FsIFBzeWNoaWF0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5Qcm9nIE5ldXJvcHN5Y2hvcGhh

cm1hY29sIEJpb2wgUHN5Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE1

MzgtMTU0NDwvcGFnZXM+PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxyZXBy

aW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFsemhlaW1lciBEaXNlYXNlL2JsIFtCbG9vZF0gKkFs

emhlaW1lciBEaXNlYXNlL2R0IFtEcnVnIFRoZXJhcHldIEFsemhlaW1lciBEaXNlYXNlL3B4IFtQ

c3ljaG9sb2d5XSBDb2duaXRpb24gRGlzb3JkZXJzL2JsIFtCbG9vZF0gKkNvZ25pdGlvbiBEaXNv

cmRlcnMvZHQgW0RydWcgVGhlcmFweV0gQ29nbml0aW9uIERpc29yZGVycy9weCBbUHN5Y2hvbG9n

eV0gRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MDI3OC01ODQ2PC9pc2JuPjx3b3JrLXR5cGU+

aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnBucGJwLjIwMDguMDUuMDE1O1JhbmRvbWl6ZWQg

Q29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93

b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20v

b3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZh

bXA7RD1tZWQ1JmFtcDtBTj0xODU3MzU4NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9z

aWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NTczNTg1JmFtcDtpZD1kb2k6MTAuMTAxNiUy

RmoucG5wYnAuMjAwOC4wNS4wMTUmYW1wO2lzc249MDI3OC01ODQ2JmFtcDtpc2JuPSZhbXA7dm9s

dW1lPTMyJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT0xNTM4JmFtcDtwYWdlcz0xNTM4LTQ0JmFtcDtk

YXRlPTIwMDgmYW1wO3RpdGxlPVByb2dyZXNzK2luK05ldXJvLVBzeWNob3BoYXJtYWNvbG9neSsl

MjYrQmlvbG9naWNhbCtQc3ljaGlhdHJ5JmFtcDthdGl0bGU9VGhlK2VmZmVjdHMrb2Yrb21lZ2Et

MytmYXR0eSthY2lkcyttb25vdGhlcmFweStpbitBbHpoZWltZXIlMjdzK2Rpc2Vhc2UrYW5kK21p

bGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYStwcmVsaW1pbmFyeStyYW5kb21pemVkK2RvdWJs

ZS1ibGluZCtwbGFjZWJvLWNvbnRyb2xsZWQrc3R1ZHkuJmFtcDthdWxhc3Q9Q2hpdTwvdXJsPjwv

cmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwv

QXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4xMzIwMzwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTMyMDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxNjc5NyI+MTMyMDM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJh

dWNoLCBCLjwvYXV0aG9yPjxhdXRob3I+U2NoaWVsZSwgUi48L2F1dGhvcj48YXV0aG9yPlNjaG5l

aWRlciwgUy48L2F1dGhvcj48YXV0aG9yPkRpbGxlciwgRi48L2F1dGhvcj48YXV0aG9yPlZpY3Rv

ciwgTi48L2F1dGhvcj48YXV0aG9yPkdvaGxrZSwgSC48L2F1dGhvcj48YXV0aG9yPkdvdHR3aWss

IE0uPC9hdXRob3I+PGF1dGhvcj5TdGVpbmJlY2ssIEcuPC9hdXRob3I+PGF1dGhvcj5EZWwgQ2Fz

dGlsbG8sIFUuPC9hdXRob3I+PGF1dGhvcj5TYWNrLCBSLjwvYXV0aG9yPjxhdXRob3I+V29ydGgs

IEguPC9hdXRob3I+PGF1dGhvcj5LYXR1cywgSC48L2F1dGhvcj48YXV0aG9yPlNwaXR6ZXIsIFcu

PC9hdXRob3I+PGF1dGhvcj5TYWJpbiwgRy48L2F1dGhvcj48YXV0aG9yPlNlbmdlcywgSi48L2F1

dGhvcj48YXV0aG9yPkdyb3VwLCBPbWVnYSBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPlJhdWNoLEJlcm5oYXJkLiBJbnN0aXR1dCBmdXIgSGVyemlu

ZmFya3Rmb3JzY2h1bmcgTHVkd2lnc2hhZmVuYW4gZGVyIFVuaXZlcnNpdGF0IEhlaWRlbGJlcmcs

IEdlcm1hbnkuIHJhdWNoQHphci1rYXJkaW8tbHVkd2lnc2hhZmVuLmRlPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+T01FR0EsIGEgcmFuZG9taXplZCwgcGxhY2Viby1jb250cm9sbGVkIHRy

aWFsIHRvIHRlc3QgdGhlIGVmZmVjdCBvZiBoaWdobHkgcHVyaWZpZWQgb21lZ2EtMyBmYXR0eSBh

Y2lkcyBvbiB0b3Agb2YgbW9kZXJuIGd1aWRlbGluZS1hZGp1c3RlZCB0aGVyYXB5IGFmdGVyIG15

b2NhcmRpYWwgaW5mYXJjdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DaXJjdWxhdGlvbjwv

c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2lyY3VsYXRpb248L2FsdC10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNpcmN1bGF0aW9uPC9mdWxsLXRpdGxl

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIxNTItMjE1OTwvcGFnZXM+PHZvbHVtZT4xMjI8L3Zv

bHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVw

cmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIENvbWJpbmVkIE1vZGFsaXR5IFRo

ZXJhcHkgRGVhdGgsU3VkZGVuLENhcmRpYWMvZXAgW0VwaWRlbWlvbG9neV0gKkRlYXRoLFN1ZGRl

bixDYXJkaWFjL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdICpGYXR0eSBBY2lkcyxPbWVn

YS0zL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdIEZhdHR5IEFjaWRzLE9tZWdhLTMv

YWUgW0FkdmVyc2UgRWZmZWN0c10gRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEZvb2QgSGFiaXRz

IEh1bTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTUyNC00NTM5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2

MS9DSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQg

Q29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93

b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20v

b3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZh

bXA7RD1tZWQ1JmFtcDtBTj0yMTA2MDA3MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9z

aWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMDYwMDcxJmFtcDtpZD1kb2k6MTAuMTE2MSUy

RkNJUkNVTEFUSU9OQUhBLjExMC45NDg1NjImYW1wO2lzc249MDAwOS03MzIyJmFtcDtpc2JuPSZh

bXA7dm9sdW1lPTEyMiZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIxNTImYW1wO3BhZ2VzPTIxNTIt

OSZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1DaXJjdWxhdGlvbiZhbXA7YXRpdGxlPU9NRUdBJTJD

K2ErcmFuZG9taXplZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwrdG8rdGVzdCt0aGUrZWZm

ZWN0K29mK2hpZ2hseStwdXJpZmllZCtvbWVnYS0zK2ZhdHR5K2FjaWRzK29uK3RvcCtvZittb2Rl

cm4rZ3VpZGVsaW5lLWFkanVzdGVkK3RoZXJhcHkrYWZ0ZXIrbXlvY2FyZGlhbCtpbmZhcmN0aW9u

LiZhbXA7YXVsYXN0PVJhdWNoPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkFTQ0VORCBTdHVkeSBDb2xsYWJvcmF0aXZlIEdyb3VwPC9BdXRo

b3I+PFllYXI+MjAxODwvWWVhcj48UmVjTnVtPjIxNzAxPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4yMTcwMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTQyMTQw

NjI5Ij4yMTcwMTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QVNDRU5E

IFN0dWR5IENvbGxhYm9yYXRpdmUgR3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2YgbuKIkjMgRmF0dHkgQWNpZCBTdXBwbGVtZW50

cyBpbiBEaWFiZXRlcyBNZWxsaXR1czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXcgRW5nbGFu

ZCBKb3VybmFsIG9mIE1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRs

ZT48YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJy

LTM+VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGlj

YWw+PHBhZ2VzPjE1NDAtMTU1MDwvcGFnZXM+PHZvbHVtZT4zNzk8L3ZvbHVtZT48bnVtYmVyPjE2

PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDE4LzEw

LzE4PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5NYXNzYWNodXNldHRzIE1l

ZGljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2JuPjAwMjgtNDc5MzwvaXNibj48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly9kb2kub3JnLzEwLjEwNTYvTkVKTW9hMTgwNDk4OTwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1Ni9O

RUpNb2ExODA0OTg5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48YWNjZXNzLWRhdGU+MjAxOC8x

MS8xMzwvYWNjZXNzLWRhdGU+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RXN0cnVjaDwv

QXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT4xODA4NDwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTgwODQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDMwMzk1MiI+MTgwODQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkVz

dHJ1Y2gsIFIuPC9hdXRob3I+PGF1dGhvcj5Sb3MsIEUuPC9hdXRob3I+PGF1dGhvcj5TYWxhcy1T

YWx2YWTDsywgSi48L2F1dGhvcj48YXV0aG9yPkNvdmFzLCBNLjwvYXV0aG9yPjxhdXRob3I+Q29y

ZWxsYSwgRC48L2F1dGhvcj48YXV0aG9yPkFyw7NzIEYgZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5SZXRyYWN0aW9uIGFuZCByZXB1YmxpY2F0

aW9uOiBQcmltYXJ5IHByZXZlbnRpb24gb2YgY2FyZGlvdmFzY3VsYXIgZGlzZWFzZSB3aXRoIGEg

TWVkaXRlcnJhbmVhbiBkaWV0LiBOIEVuZ2wgSiBNZWQgMjAxMzsgMzY4OjEyNzktOTA8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpv

dXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnIt

MT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9m

IE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNS0yNTwvcGFnZXM+PHZvbHVt

ZT4zNzg8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJs

cz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HYWxhbjwvQXV0aG9yPjxZZWFyPjIwMTA8

L1llYXI+PFJlY051bT41MjM2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41MjM2PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVl

NWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTIzMDAiPjUyMzY8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhbGFuLCBQLjwvYXV0aG9yPjxhdXRo

b3I+S2Vzc2UtR3V5b3QsIEUuPC9hdXRob3I+PGF1dGhvcj5DemVybmljaG93LCBTLjwvYXV0aG9y

PjxhdXRob3I+QnJpYW5jb24sIFMuPC9hdXRob3I+PGF1dGhvcj5CbGFjaGVyLCBKLjwvYXV0aG9y

PjxhdXRob3I+SGVyY2JlcmcsIFMuPC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgU3UgRm9sIE9tIENv

bGxhYm9yYXRpdmU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5HYWxhbixQaWxhci4gVU1SIFU1NTcgSW5zZXJtLCBVMTEyNSBJbnJhLCBDbmFtLCBVbml2ZXJz

aXRlIFBhcmlzIDEzLCBDUk5IIElkRiwgRi05MzAxNyBCb2JpZ255LCBGcmFuY2UuIHAuZ2FsYW5A

dXJlbi5zbWJoLnVuaXYtcGFyaXMxMy5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVm

ZmVjdHMgb2YgQiB2aXRhbWlucyBhbmQgb21lZ2EgMyBmYXR0eSBhY2lkcyBvbiBjYXJkaW92YXNj

dWxhciBkaXNlYXNlczogYSByYW5kb21pc2VkIHBsYWNlYm8gY29udHJvbGxlZCB0cmlhbDwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5CTUo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJtajwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggTWVkaWNh

bCBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QnIgTWVkIEo8L2FiYnItMT48YWJici0yPkJN

SjwvYWJici0yPjxhYmJyLTM+Qm1qPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5Ccml0aXNoIE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0x

PkJyIE1lZCBKPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0z

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmM2MjczPC9wYWdlcz48dm9sdW1lPjM0MTwvdm9sdW1l

PjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+

PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFuZ2luYSxVbnN0YWJsZS9kaCBbRGlldCBU

aGVyYXB5XSBCaW9tYXJrZXJzL2JsIFtCbG9vZF0gKkNhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzL3Bj

IFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJs

aW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtNi9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsg

RG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS02L2JsIFtCbG9vZF0gRjwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTc1Ni0xODMzPC9pc2Ju

Pjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9ibWouYzYyNzM7TXVsdGljZW50

ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5v

bi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O

JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTIxMTE1NTg5aHR0cDovL3NmeC51

Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjExMTU1ODkm

YW1wO2lkPWRvaToxMC4xMTM2JTJGYm1qLmM2MjczJmFtcDtpc3NuPTA5NTktNTM1WCZhbXA7aXNi

bj0mYW1wO3ZvbHVtZT0zNDEmYW1wO2lzc3VlPTI5JmFtcDtzcGFnZT1jNjI3MyZhbXA7cGFnZXM9

YzYyNzMmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Qk1KJmFtcDthdGl0bGU9RWZmZWN0cytvZitC

K3ZpdGFtaW5zK2FuZCtvbWVnYSszK2ZhdHR5K2FjaWRzK29uK2NhcmRpb3Zhc2N1bGFyK2Rpc2Vh

c2VzJTNBK2ErcmFuZG9taXNlZCtwbGFjZWJvK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9

R2FsYW48L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90

ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLTQsIDEwLCAxMywgMTUsIDM1KTwv

RGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRm

ZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48

cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y

cz48YXV0aG9ycz48YXV0aG9yPktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBF

LiBKLjwvYXV0aG9yPjxhdXRob3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxw

aGEgT21lZ2EgVHJpYWwgR3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+S3JvbWhvdXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBX

YWdlbmluZ2VuIFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5r

cm9taG91dEB3dXIubmw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNp

ZHMgYW5kIGNhcmRpb3Zhc2N1bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwv

c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2lu

ZTwvZnVsbC10aXRsZT48YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwv

YWJici0yPjxhYmJyLTM+VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnIt

Mz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpv

dXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnIt

MT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9m

IE1lZGljaW5lPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdl

cz48dm9sdW1lPjM2Mzwvdm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9u

Pk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdl

ZCw4MCBhbmQgb3ZlciBDYXJkaW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAq

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGll

dGFyeSBTdXBwbGVtZW50cyBEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0

c10gRG9jb3NhaGV4YWVub2ljIEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGlu

ZCBNZXRob2QgRHJ1ZyBUaGVyYXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw

MTA8L3llYXI+PC9kYXRlcz48aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8v

ZHguZG9pLm9yZy8xMC4xMDU2L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9t

aXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtB

Tj0yMDkyOTM0MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjIwOTI5MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMm

YW1wO2lzc249MDAyOC00NzkzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEm

YW1wO3NwYWdlPTIwMTUmYW1wO3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9

TmV3K0VuZ2xhbmQrSm91cm5hbCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lk

cythbmQrY2FyZGlvdmFzY3VsYXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4m

YW1wO2F1bGFzdD1Lcm9taG91dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVt

PjI4MzA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVp

Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0

dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUzMDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hldywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMs

IFQuIEUuPC9hdXRob3I+PGF1dGhvcj5BZ3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwg

TC4gSi48L2F1dGhvcj48YXV0aG9yPkdyb2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5z

dGVpbiwgUC4gUy48L2F1dGhvcj48YXV0aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVk

eTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1p

bHkgWS4gRGl2aXNpb24gb2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMs

IENsaW5pY2FsIFRyaWFscyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwg

SW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBF

LiBUaGUgRU1NRVMgQ29ycG9yYXRpb24sIFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmly

YS4gRGl2aXNpb24gb2YgRXBpZGVtaW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENs

aW5pY2FsIFRyaWFscyBCcmFuY2gsIE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5z

dGl0dXRlcyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBO

ZXVyb2VwaWRlbWlvbG9neSBTZWN0aW9uLCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0

aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWlu

LEZyYW5jaW5lLiBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9z

O3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVkaWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0

czVEZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhl

YWx0aCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUg

Q2VudGVyLCBVbml2ZXJzaXR5IG9mIFV0YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4

YW50aGluLCBvciBPdGhlciBOdXRyaWVudCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1

bmN0aW9uOiBUaGUgQVJFRFMyIFJhbmRvbWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+SkFNQTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhl

IEFtZXJpY2FuIE1lZGljYWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9h

YmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3Vy

bmFsIG9mIHRoZSBBbWVyaWNhbiBNZWRpY2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJy

LTE+SkFNQTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2

b2x1bWU+MzE0PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1Qg

SU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAg

YW5kIG92ZXIgQWxnb3JpdGhtcyBBc2NvcmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w

OyBEb3NhZ2VdICpDb2duaXRpb24gQ29udGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVy

L2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpE

b2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91

YmxlLUJsaW5kIE1ldGhvZCAqRWljb3NhPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy

PjIwMTU8L3llYXI+PC9kYXRlcz48aXNibj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRw

Oi8vZHguZG9pLm9yZy8xMC4xMDAxL2phbWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJh

bmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJh

bXVyYWw8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5v

dmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1

bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4

X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaTox

MC4xMDAxJTJGamFtYS4yMDE1Ljk2NzcmYW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7

dm9sdW1lPTMxNCZhbXA7aXNzdWU9OCZhbXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFt

cDtkYXRlPTIwMTUmYW1wO3RpdGxlPUpBTUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytG

YXR0eStBY2lkcyUyQytMdXRlaW4lMkZaZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1

cHBsZW1lbnRhdGlvbitvbitDb2duaXRpdmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21p

emVkK0NsaW5pY2FsK1RyaWFsLiZhbXA7YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48

L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2hpdTwvQXV0aG9yPjxZZWFyPjIw

MDg8L1llYXI+PFJlY051bT4yODYyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yODYyPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZz

czVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTEwMDAiPjI4NjI8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNoaXUsIEMuIEMuPC9hdXRob3I+

PGF1dGhvcj5TdSwgSy4gUC48L2F1dGhvcj48YXV0aG9yPkNoZW5nLCBULiBDLjwvYXV0aG9yPjxh

dXRob3I+TGl1LCBILiBDLjwvYXV0aG9yPjxhdXRob3I+Q2hhbmcsIEMuIEouPC9hdXRob3I+PGF1

dGhvcj5EZXdleSwgTS4gRS48L2F1dGhvcj48YXV0aG9yPlN0ZXdhcnQsIFIuPC9hdXRob3I+PGF1

dGhvcj5IdWFuZywgUy4gWS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt

YWRkcmVzcz5DaGl1LENoaWgtQ2hpYW5nLiBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnksIFRhaXBl

aSBDaXR5IFBzeWNoaWF0cmljIENlbnRlciwgVGFpcGVpIENpdHkgSG9zcGl0YWwsIERlcGFydG1l

bnQgb2YgUHN5Y2hpYXRyeSwgVGFpcGVpIE1lZGljYWwgVW5pdmVyc2l0eSwgVGFpcGVpLCBUYWl3

YW48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0cyBvZiBvbWVnYS0zIGZh

dHR5IGFjaWRzIG1vbm90aGVyYXB5IGluIEFsemhlaW1lciZhcG9zO3MgZGlzZWFzZSBhbmQgbWls

ZCBjb2duaXRpdmUgaW1wYWlybWVudDogYSBwcmVsaW1pbmFyeSByYW5kb21pemVkIGRvdWJsZS1i

bGluZCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UHJv

Z3Jlc3MgaW4gTmV1cm8tUHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7IEJpb2xvZ2ljYWwgUHN5Y2hp

YXRyeTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNv

bCBCaW9sIFBzeWNoaWF0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5Qcm9ncmVzcyBpbiBOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3kgJmFtcDsgQmlvbG9naWNh

bCBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNv

bCBCaW9sIFBzeWNoaWF0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPlByb2dyZXNzIGluIE5ldXJvLVBzeWNob3BoYXJtYWNvbG9neSAmYW1wOyBCaW9s

b2dpY2FsIFBzeWNoaWF0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5Qcm9nIE5ldXJvcHN5Y2hvcGhh

cm1hY29sIEJpb2wgUHN5Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE1

MzgtMTU0NDwvcGFnZXM+PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxyZXBy

aW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFsemhlaW1lciBEaXNlYXNlL2JsIFtCbG9vZF0gKkFs

emhlaW1lciBEaXNlYXNlL2R0IFtEcnVnIFRoZXJhcHldIEFsemhlaW1lciBEaXNlYXNlL3B4IFtQ

c3ljaG9sb2d5XSBDb2duaXRpb24gRGlzb3JkZXJzL2JsIFtCbG9vZF0gKkNvZ25pdGlvbiBEaXNv

cmRlcnMvZHQgW0RydWcgVGhlcmFweV0gQ29nbml0aW9uIERpc29yZGVycy9weCBbUHN5Y2hvbG9n

eV0gRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MDI3OC01ODQ2PC9pc2JuPjx3b3JrLXR5cGU+

aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnBucGJwLjIwMDguMDUuMDE1O1JhbmRvbWl6ZWQg

Q29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93

b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20v

b3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZh

bXA7RD1tZWQ1JmFtcDtBTj0xODU3MzU4NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9z

aWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NTczNTg1JmFtcDtpZD1kb2k6MTAuMTAxNiUy

RmoucG5wYnAuMjAwOC4wNS4wMTUmYW1wO2lzc249MDI3OC01ODQ2JmFtcDtpc2JuPSZhbXA7dm9s

dW1lPTMyJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT0xNTM4JmFtcDtwYWdlcz0xNTM4LTQ0JmFtcDtk

YXRlPTIwMDgmYW1wO3RpdGxlPVByb2dyZXNzK2luK05ldXJvLVBzeWNob3BoYXJtYWNvbG9neSsl

MjYrQmlvbG9naWNhbCtQc3ljaGlhdHJ5JmFtcDthdGl0bGU9VGhlK2VmZmVjdHMrb2Yrb21lZ2Et

MytmYXR0eSthY2lkcyttb25vdGhlcmFweStpbitBbHpoZWltZXIlMjdzK2Rpc2Vhc2UrYW5kK21p

bGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYStwcmVsaW1pbmFyeStyYW5kb21pemVkK2RvdWJs

ZS1ibGluZCtwbGFjZWJvLWNvbnRyb2xsZWQrc3R1ZHkuJmFtcDthdWxhc3Q9Q2hpdTwvdXJsPjwv

cmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwv

QXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4xMzIwMzwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTMyMDM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxNjc5NyI+MTMyMDM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJh

dWNoLCBCLjwvYXV0aG9yPjxhdXRob3I+U2NoaWVsZSwgUi48L2F1dGhvcj48YXV0aG9yPlNjaG5l

aWRlciwgUy48L2F1dGhvcj48YXV0aG9yPkRpbGxlciwgRi48L2F1dGhvcj48YXV0aG9yPlZpY3Rv

ciwgTi48L2F1dGhvcj48YXV0aG9yPkdvaGxrZSwgSC48L2F1dGhvcj48YXV0aG9yPkdvdHR3aWss

IE0uPC9hdXRob3I+PGF1dGhvcj5TdGVpbmJlY2ssIEcuPC9hdXRob3I+PGF1dGhvcj5EZWwgQ2Fz

dGlsbG8sIFUuPC9hdXRob3I+PGF1dGhvcj5TYWNrLCBSLjwvYXV0aG9yPjxhdXRob3I+V29ydGgs

IEguPC9hdXRob3I+PGF1dGhvcj5LYXR1cywgSC48L2F1dGhvcj48YXV0aG9yPlNwaXR6ZXIsIFcu

PC9hdXRob3I+PGF1dGhvcj5TYWJpbiwgRy48L2F1dGhvcj48YXV0aG9yPlNlbmdlcywgSi48L2F1

dGhvcj48YXV0aG9yPkdyb3VwLCBPbWVnYSBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPlJhdWNoLEJlcm5oYXJkLiBJbnN0aXR1dCBmdXIgSGVyemlu

ZmFya3Rmb3JzY2h1bmcgTHVkd2lnc2hhZmVuYW4gZGVyIFVuaXZlcnNpdGF0IEhlaWRlbGJlcmcs

IEdlcm1hbnkuIHJhdWNoQHphci1rYXJkaW8tbHVkd2lnc2hhZmVuLmRlPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+T01FR0EsIGEgcmFuZG9taXplZCwgcGxhY2Viby1jb250cm9sbGVkIHRy

aWFsIHRvIHRlc3QgdGhlIGVmZmVjdCBvZiBoaWdobHkgcHVyaWZpZWQgb21lZ2EtMyBmYXR0eSBh

Y2lkcyBvbiB0b3Agb2YgbW9kZXJuIGd1aWRlbGluZS1hZGp1c3RlZCB0aGVyYXB5IGFmdGVyIG15

b2NhcmRpYWwgaW5mYXJjdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DaXJjdWxhdGlvbjwv

c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2lyY3VsYXRpb248L2FsdC10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10aXRsZT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNpcmN1bGF0aW9uPC9mdWxsLXRpdGxl

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIxNTItMjE1OTwvcGFnZXM+PHZvbHVtZT4xMjI8L3Zv

bHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVw

cmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIENvbWJpbmVkIE1vZGFsaXR5IFRo

ZXJhcHkgRGVhdGgsU3VkZGVuLENhcmRpYWMvZXAgW0VwaWRlbWlvbG9neV0gKkRlYXRoLFN1ZGRl

bixDYXJkaWFjL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdICpGYXR0eSBBY2lkcyxPbWVn

YS0zL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdIEZhdHR5IEFjaWRzLE9tZWdhLTMv

YWUgW0FkdmVyc2UgRWZmZWN0c10gRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEZvb2QgSGFiaXRz

IEh1bTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTUyNC00NTM5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2

MS9DSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQg

Q29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93

b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20v

b3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZh

bXA7RD1tZWQ1JmFtcDtBTj0yMTA2MDA3MWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9z

aWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMDYwMDcxJmFtcDtpZD1kb2k6MTAuMTE2MSUy

RkNJUkNVTEFUSU9OQUhBLjExMC45NDg1NjImYW1wO2lzc249MDAwOS03MzIyJmFtcDtpc2JuPSZh

bXA7dm9sdW1lPTEyMiZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIxNTImYW1wO3BhZ2VzPTIxNTIt

OSZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1DaXJjdWxhdGlvbiZhbXA7YXRpdGxlPU9NRUdBJTJD

K2ErcmFuZG9taXplZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwrdG8rdGVzdCt0aGUrZWZm

ZWN0K29mK2hpZ2hseStwdXJpZmllZCtvbWVnYS0zK2ZhdHR5K2FjaWRzK29uK3RvcCtvZittb2Rl

cm4rZ3VpZGVsaW5lLWFkanVzdGVkK3RoZXJhcHkrYWZ0ZXIrbXlvY2FyZGlhbCtpbmZhcmN0aW9u

LiZhbXA7YXVsYXN0PVJhdWNoPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkFTQ0VORCBTdHVkeSBDb2xsYWJvcmF0aXZlIEdyb3VwPC9BdXRo

b3I+PFllYXI+MjAxODwvWWVhcj48UmVjTnVtPjIxNzAxPC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4yMTcwMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTQyMTQw

NjI5Ij4yMTcwMTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QVNDRU5E

IFN0dWR5IENvbGxhYm9yYXRpdmUgR3JvdXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2YgbuKIkjMgRmF0dHkgQWNpZCBTdXBwbGVtZW50

cyBpbiBEaWFiZXRlcyBNZWxsaXR1czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXcgRW5nbGFu

ZCBKb3VybmFsIG9mIE1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRs

ZT48YWJici0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJy

LTM+VGhlIE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGlj

YWw+PHBhZ2VzPjE1NDAtMTU1MDwvcGFnZXM+PHZvbHVtZT4zNzk8L3ZvbHVtZT48bnVtYmVyPjE2

PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDE4LzEw

LzE4PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5NYXNzYWNodXNldHRzIE1l

ZGljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2JuPjAwMjgtNDc5MzwvaXNibj48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly9kb2kub3JnLzEwLjEwNTYvTkVKTW9hMTgwNDk4OTwvdXJs

PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1Ni9O

RUpNb2ExODA0OTg5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48YWNjZXNzLWRhdGU+MjAxOC8x

MS8xMzwvYWNjZXNzLWRhdGU+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RXN0cnVjaDwv

QXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT4xODA4NDwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTgwODQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDMwMzk1MiI+MTgwODQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkVz

dHJ1Y2gsIFIuPC9hdXRob3I+PGF1dGhvcj5Sb3MsIEUuPC9hdXRob3I+PGF1dGhvcj5TYWxhcy1T

YWx2YWTDsywgSi48L2F1dGhvcj48YXV0aG9yPkNvdmFzLCBNLjwvYXV0aG9yPjxhdXRob3I+Q29y

ZWxsYSwgRC48L2F1dGhvcj48YXV0aG9yPkFyw7NzIEYgZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5SZXRyYWN0aW9uIGFuZCByZXB1YmxpY2F0

aW9uOiBQcmltYXJ5IHByZXZlbnRpb24gb2YgY2FyZGlvdmFzY3VsYXIgZGlzZWFzZSB3aXRoIGEg

TWVkaXRlcnJhbmVhbiBkaWV0LiBOIEVuZ2wgSiBNZWQgMjAxMzsgMzY4OjEyNzktOTA8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25k

YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpv

dXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnIt

MT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9m

IE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz4yNS0yNTwvcGFnZXM+PHZvbHVt

ZT4zNzg8L3ZvbHVtZT48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJs

cz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HYWxhbjwvQXV0aG9yPjxZZWFyPjIwMTA8

L1llYXI+PFJlY051bT41MjM2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41MjM2PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVl

NWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAyMTIzMDAiPjUyMzY8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhbGFuLCBQLjwvYXV0aG9yPjxhdXRo

b3I+S2Vzc2UtR3V5b3QsIEUuPC9hdXRob3I+PGF1dGhvcj5DemVybmljaG93LCBTLjwvYXV0aG9y

PjxhdXRob3I+QnJpYW5jb24sIFMuPC9hdXRob3I+PGF1dGhvcj5CbGFjaGVyLCBKLjwvYXV0aG9y

PjxhdXRob3I+SGVyY2JlcmcsIFMuPC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgU3UgRm9sIE9tIENv

bGxhYm9yYXRpdmU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz

cz5HYWxhbixQaWxhci4gVU1SIFU1NTcgSW5zZXJtLCBVMTEyNSBJbnJhLCBDbmFtLCBVbml2ZXJz

aXRlIFBhcmlzIDEzLCBDUk5IIElkRiwgRi05MzAxNyBCb2JpZ255LCBGcmFuY2UuIHAuZ2FsYW5A

dXJlbi5zbWJoLnVuaXYtcGFyaXMxMy5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVm

ZmVjdHMgb2YgQiB2aXRhbWlucyBhbmQgb21lZ2EgMyBmYXR0eSBhY2lkcyBvbiBjYXJkaW92YXNj

dWxhciBkaXNlYXNlczogYSByYW5kb21pc2VkIHBsYWNlYm8gY29udHJvbGxlZCB0cmlhbDwvdGl0

bGU+PHNlY29uZGFyeS10aXRsZT5CTUo8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJtajwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJyaXRpc2ggTWVkaWNh

bCBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QnIgTWVkIEo8L2FiYnItMT48YWJici0yPkJN

SjwvYWJici0yPjxhYmJyLTM+Qm1qPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5Ccml0aXNoIE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0x

PkJyIE1lZCBKPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0z

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmM2MjczPC9wYWdlcz48dm9sdW1lPjM0MTwvdm9sdW1l

PjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+

PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFuZ2luYSxVbnN0YWJsZS9kaCBbRGlldCBU

aGVyYXB5XSBCaW9tYXJrZXJzL2JsIFtCbG9vZF0gKkNhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzL3Bj

IFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJs

aW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtNi9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsg

RG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS02L2JsIFtCbG9vZF0gRjwva2V5d29yZD48L2tleXdv

cmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTc1Ni0xODMzPC9pc2Ju

Pjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9ibWouYzYyNzM7TXVsdGljZW50

ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5v

bi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O

JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTIxMTE1NTg5aHR0cDovL3NmeC51

Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjExMTU1ODkm

YW1wO2lkPWRvaToxMC4xMTM2JTJGYm1qLmM2MjczJmFtcDtpc3NuPTA5NTktNTM1WCZhbXA7aXNi

bj0mYW1wO3ZvbHVtZT0zNDEmYW1wO2lzc3VlPTI5JmFtcDtzcGFnZT1jNjI3MyZhbXA7cGFnZXM9

YzYyNzMmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Qk1KJmFtcDthdGl0bGU9RWZmZWN0cytvZitC

K3ZpdGFtaW5zK2FuZCtvbWVnYSszK2ZhdHR5K2FjaWRzK29uK2NhcmRpb3Zhc2N1bGFyK2Rpc2Vh

c2VzJTNBK2ErcmFuZG9taXNlZCtwbGFjZWJvK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9

R2FsYW48L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90

ZT4A

ADDIN EN.CITE.DATA (2-4, 10, 13, 15, 35), so that more than1000 participants were involved in assessments of LCn3, ALA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxhdXRo

b3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwgR3Jv

dXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3JvbWhv

dXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZlcnNp

dHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zhc2N1

bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJi

ci0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+VGhl

IE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8

L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2Fi

YnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+

PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwvdm9s

dW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBDYXJk

aW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIgRGlz

ZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50cyBE

b2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVub2lj

IEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBUaGVy

YXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48

aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDU2

L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRy

aWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6Ly9z

ZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwOTI5

MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00Nzkz

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUmYW1w

O3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91cm5h

bCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFzY3Vs

YXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9taG91

dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj44NjMxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTQyMTEiPjg2MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

Pktyb21ob3V0LCBELjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLiBKLjwvYXV0aG9yPjxhdXRo

b3I+R2VsZWlqbnNlLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+QWxwaGEgT21lZ2EgVHJpYWwgR3Jv

dXAsPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+S3JvbWhv

dXQsRGFhbi4gRGl2aXNpb24gb2YgSHVtYW4gTnV0cml0aW9uLCBXYWdlbmluZ2VuIFVuaXZlcnNp

dHksIFdhZ2VuaW5nZW4sIFRoZSBOZXRoZXJsYW5kcy4gZGFhbi5rcm9taG91dEB3dXIubmw8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5uLTMgZmF0dHkgYWNpZHMgYW5kIGNhcmRpb3Zhc2N1

bGFyIGV2ZW50cyBhZnRlciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJi

ci0xPk4gRW5nbCBKIE1lZDwvYWJici0xPjxhYmJyLTI+TkVKTTwvYWJici0yPjxhYmJyLTM+VGhl

IE5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2FiYnItMz48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8

L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2Fi

YnItMj48YWJici0zPlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+

PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjAxNS0yMDI2PC9wYWdlcz48dm9sdW1lPjM2Mzwvdm9s

dW1lPjxudW1iZXI+MjE8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBDYXJk

aW92YXNjdWxhciBEaXNlYXNlcy9lcCBbRXBpZGVtaW9sb2d5XSAqQ2FyZGlvdmFzY3VsYXIgRGlz

ZWFzZXMvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGlldGFyeSBTdXBwbGVtZW50cyBE

b2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWUgW0FkdmVyc2UgRWZmZWN0c10gRG9jb3NhaGV4YWVub2lj

IEFjaWRzL3R1IFtUaGVyYXBldXRpYyBVc2VdIERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBUaGVy

YXB5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PC9kYXRlcz48

aXNibj4xNTMzLTQ0MDY8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDU2

L05FSk1vYTEwMDM2MDM7TXVsdGljZW50ZXIgU3R1ZHkgUmFuZG9taXplZCBDb250cm9sbGVkIFRy

aWFsIFJlc2VhcmNoIFN1cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbCBSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDkyOTM0MWh0dHA6Ly9z

ZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwOTI5

MzQxJmFtcDtpZD1kb2k6MTAuMTA1NiUyRk5FSk1vYTEwMDM2MDMmYW1wO2lzc249MDAyOC00Nzkz

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTM2MyZhbXA7aXNzdWU9MjEmYW1wO3NwYWdlPTIwMTUmYW1w

O3BhZ2VzPTIwMTUtMjYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9TmV3K0VuZ2xhbmQrSm91cm5h

bCtvZitNZWRpY2luZSZhbXA7YXRpdGxlPW4tMytmYXR0eSthY2lkcythbmQrY2FyZGlvdmFzY3Vs

YXIrZXZlbnRzK2FmdGVyK215b2NhcmRpYWwraW5mYXJjdGlvbi4mYW1wO2F1bGFzdD1Lcm9taG91

dDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (2) and total PUFA ADDIN EN.CITE <EndNote><Cite><Author>Estruch</Author><Year>2018</Year><RecNum>18084</RecNum><DisplayText>(35)</DisplayText><record><rec-number>18084</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530303952">18084</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Estruch, R.</author><author>Ros, E.</author><author>Salas-Salvadó, J.</author><author>Covas, M.</author><author>Corella, D.</author><author>Arós F et, a l</author></authors></contributors><titles><title>Retraction and republication: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368:1279-90</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N Engl J Med</abbr-1><abbr-2>NEJM</abbr-2><abbr-3>The New England Journal of Medicine</abbr-3></periodical><pages>25-25</pages><volume>378</volume><dates><year>2018</year></dates><urls></urls></record></Cite></EndNote>(35). Control groups received olive, corn or sunflower oils, other fats, other 'inert' or ill-defined substances, different dietary advice, foods without omega-3 enrichment, or nothing. Trial authors provided some response to attempted contact for 16 trials. Does increasing omega-3, omega-6 or total PUFA alter risk of depression or anxiety?Key evidence is provided in the three GRADE tables summarising evidence on effects of LCn3, ALA and total PUFA on primary outcomes (Supplementary Tables 3, 6 and 7), in forest plots showing meta-analyses (Figures 2 and 3, Supplementary Figures 2-4, 6-8 and 10) and funnel plots (Supplementary Figures 5 and 9). Risk of depression symptomsThirteen RCTs randomised 26,528 participants to higher vs lower LCn3 and reported on 1355 people found to have symptoms of depression (RR 1.01, 95% CI 0.92 to 1.10, I2 0%, 5% incidence, Figure 2). In these trials mean LCn3 dose was 1.4g/d (SD 0.9), median dose was 0.95g/d (range 0.4 to 3.4), mean trial duration was 24.2 months (SD 25.1), median duration was 12 months (range 6 to 89 months). The four largest trials tended to be longer but lower dose than average. This lack of effect of LCn3 on risk of depression did not differ in sensitivity analyses by risk of bias, fixed effects or study size, though retaining only trials with good compliance suggested increased risk of depression diagnosis with increased LCn3 (RR 1.16, 95% CI 0.99 to 1.36, I2 0%, Supplementary Table 2). Over 90% of meta-analytic weight came from three trials that assessed depression using the Center for Epidemiologic Studies Depression Scale (CESD, score ≥16PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

TnVtPjI4MzA8L1JlY051bT48RGlzcGxheVRleHQ+KDMpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hl

dywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+PGF1dGhvcj5B

Z3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48YXV0aG9yPkdy

b2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1dGhvcj48YXV0

aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24gb2YgRXBpZGVt

aW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gs

IE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJl

dGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29ycG9yYXRpb24s

IFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2YgRXBpZGVtaW9s

b2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gsIE5h

dGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhl

c2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9neSBTZWN0aW9u

LCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBhcnRtZW50IG9m

IE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVk

aWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9mIEVwaWRlbWlv

bG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBNYXNzYWNodXNl

dHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIFV0

YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9m

IE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhlciBOdXRyaWVu

dCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJFRFMyIFJhbmRv

bWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGljYWwgQXNzb2Np

YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBNZWRp

Y2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0xPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1bWU+PG51bWJl

cj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3JpdGhtcyBBc2Nv

cmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2duaXRpb24gQ29u

dGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w

OyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWQg

W0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhvZCAqRWljb3Nh

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAxL2ph

bWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpT

JmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FO

PTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUm

YW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4yMDE1Ljk2Nzcm

YW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7aXNzdWU9OCZh

bXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1wO3RpdGxlPUpB

TUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytMdXRlaW4lMkZa

ZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitvbitDb2duaXRp

dmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1RyaWFsLiZhbXA7

YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

TnVtPjI4MzA8L1JlY051bT48RGlzcGxheVRleHQ+KDMpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hl

dywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+PGF1dGhvcj5B

Z3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48YXV0aG9yPkdy

b2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1dGhvcj48YXV0

aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24gb2YgRXBpZGVt

aW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gs

IE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJl

dGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29ycG9yYXRpb24s

IFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2YgRXBpZGVtaW9s

b2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gsIE5h

dGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhl

c2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9neSBTZWN0aW9u

LCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBhcnRtZW50IG9m

IE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVk

aWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9mIEVwaWRlbWlv

bG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBNYXNzYWNodXNl

dHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIFV0

YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9m

IE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhlciBOdXRyaWVu

dCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJFRFMyIFJhbmRv

bWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGljYWwgQXNzb2Np

YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBNZWRp

Y2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0xPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1bWU+PG51bWJl

cj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3JpdGhtcyBBc2Nv

cmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2duaXRpb24gQ29u

dGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w

OyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWQg

W0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhvZCAqRWljb3Nh

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAxL2ph

bWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpT

JmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FO

PTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUm

YW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4yMDE1Ljk2Nzcm

YW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7aXNzdWU9OCZh

bXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1wO3RpdGxlPUpB

TUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytMdXRlaW4lMkZa

ZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitvbitDb2duaXRp

dmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1RyaWFsLiZhbXA7

YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE.DATA (3)), Becks Depression Inventory (BDI-II, score ≥14PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4xMzIwMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEzMjAzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY3OTciPjEzMjAzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5SYXVjaCwgQi48L2F1dGhvcj48YXV0aG9yPlNjaGllbGUsIFIuPC9hdXRob3I+PGF1dGhvcj5T

Y2huZWlkZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5EaWxsZXIsIEYuPC9hdXRob3I+PGF1dGhvcj5W

aWN0b3IsIE4uPC9hdXRob3I+PGF1dGhvcj5Hb2hsa2UsIEguPC9hdXRob3I+PGF1dGhvcj5Hb3R0

d2lrLCBNLjwvYXV0aG9yPjxhdXRob3I+U3RlaW5iZWNrLCBHLjwvYXV0aG9yPjxhdXRob3I+RGVs

IENhc3RpbGxvLCBVLjwvYXV0aG9yPjxhdXRob3I+U2FjaywgUi48L2F1dGhvcj48YXV0aG9yPldv

cnRoLCBILjwvYXV0aG9yPjxhdXRob3I+S2F0dXMsIEguPC9hdXRob3I+PGF1dGhvcj5TcGl0emVy

LCBXLjwvYXV0aG9yPjxhdXRob3I+U2FiaW4sIEcuPC9hdXRob3I+PGF1dGhvcj5TZW5nZXMsIEou

PC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgT21lZ2EgU3R1ZHk8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5SYXVjaCxCZXJuaGFyZC4gSW5zdGl0dXQgZnVyIEhl

cnppbmZhcmt0Zm9yc2NodW5nIEx1ZHdpZ3NoYWZlbmFuIGRlciBVbml2ZXJzaXRhdCBIZWlkZWxi

ZXJnLCBHZXJtYW55LiByYXVjaEB6YXIta2FyZGlvLWx1ZHdpZ3NoYWZlbi5kZTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPk9NRUdBLCBhIHJhbmRvbWl6ZWQsIHBsYWNlYm8tY29udHJvbGxl

ZCB0cmlhbCB0byB0ZXN0IHRoZSBlZmZlY3Qgb2YgaGlnaGx5IHB1cmlmaWVkIG9tZWdhLTMgZmF0

dHkgYWNpZHMgb24gdG9wIG9mIG1vZGVybiBndWlkZWxpbmUtYWRqdXN0ZWQgdGhlcmFweSBhZnRl

ciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRp

b248L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNpcmN1bGF0aW9uPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yMTUyLTIxNTk8L3BhZ2VzPjx2b2x1bWU+MTIy

PC92b2x1bWU+PG51bWJlcj4yMTwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8

L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBDb21iaW5lZCBNb2RhbGl0

eSBUaGVyYXB5IERlYXRoLFN1ZGRlbixDYXJkaWFjL2VwIFtFcGlkZW1pb2xvZ3ldICpEZWF0aCxT

dWRkZW4sQ2FyZGlhYy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSAqRmF0dHkgQWNpZHMs

T21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVn

YS0zL2FlIFtBZHZlcnNlIEVmZmVjdHNdIEZlbWFsZSBGb2xsb3ctVXAgU3R1ZGllcyBGb29kIEhh

Yml0cyBIdW08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2Rh

dGVzPjxpc2JuPjE1MjQtNDUzOTwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEw

LjExNjEvQ0lSQ1VMQVRJT05BSEEuMTEwLjk0ODU2MjtNdWx0aWNlbnRlciBTdHVkeSBSYW5kb21p

emVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkNSZhbXA7QU49MjEwNjAwNzFodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9j

YWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMTA2MDA3MSZhbXA7aWQ9ZG9pOjEwLjEx

NjElMkZDSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyJmFtcDtpc3NuPTAwMDktNzMyMiZhbXA7aXNi

bj0mYW1wO3ZvbHVtZT0xMjImYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMTUyJmFtcDtwYWdlcz0y

MTUyLTkmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Q2lyY3VsYXRpb24mYW1wO2F0aXRsZT1PTUVH

QSUyQythK3JhbmRvbWl6ZWQlMkMrcGxhY2Viby1jb250cm9sbGVkK3RyaWFsK3RvK3Rlc3QrdGhl

K2VmZmVjdCtvZitoaWdobHkrcHVyaWZpZWQrb21lZ2EtMytmYXR0eSthY2lkcytvbit0b3Arb2Yr

bW9kZXJuK2d1aWRlbGluZS1hZGp1c3RlZCt0aGVyYXB5K2FmdGVyK215b2NhcmRpYWwraW5mYXJj

dGlvbi4mYW1wO2F1bGFzdD1SYXVjaDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4xMzIwMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEzMjAzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY3OTciPjEzMjAzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5SYXVjaCwgQi48L2F1dGhvcj48YXV0aG9yPlNjaGllbGUsIFIuPC9hdXRob3I+PGF1dGhvcj5T

Y2huZWlkZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5EaWxsZXIsIEYuPC9hdXRob3I+PGF1dGhvcj5W

aWN0b3IsIE4uPC9hdXRob3I+PGF1dGhvcj5Hb2hsa2UsIEguPC9hdXRob3I+PGF1dGhvcj5Hb3R0

d2lrLCBNLjwvYXV0aG9yPjxhdXRob3I+U3RlaW5iZWNrLCBHLjwvYXV0aG9yPjxhdXRob3I+RGVs

IENhc3RpbGxvLCBVLjwvYXV0aG9yPjxhdXRob3I+U2FjaywgUi48L2F1dGhvcj48YXV0aG9yPldv

cnRoLCBILjwvYXV0aG9yPjxhdXRob3I+S2F0dXMsIEguPC9hdXRob3I+PGF1dGhvcj5TcGl0emVy

LCBXLjwvYXV0aG9yPjxhdXRob3I+U2FiaW4sIEcuPC9hdXRob3I+PGF1dGhvcj5TZW5nZXMsIEou

PC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgT21lZ2EgU3R1ZHk8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5SYXVjaCxCZXJuaGFyZC4gSW5zdGl0dXQgZnVyIEhl

cnppbmZhcmt0Zm9yc2NodW5nIEx1ZHdpZ3NoYWZlbmFuIGRlciBVbml2ZXJzaXRhdCBIZWlkZWxi

ZXJnLCBHZXJtYW55LiByYXVjaEB6YXIta2FyZGlvLWx1ZHdpZ3NoYWZlbi5kZTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPk9NRUdBLCBhIHJhbmRvbWl6ZWQsIHBsYWNlYm8tY29udHJvbGxl

ZCB0cmlhbCB0byB0ZXN0IHRoZSBlZmZlY3Qgb2YgaGlnaGx5IHB1cmlmaWVkIG9tZWdhLTMgZmF0

dHkgYWNpZHMgb24gdG9wIG9mIG1vZGVybiBndWlkZWxpbmUtYWRqdXN0ZWQgdGhlcmFweSBhZnRl

ciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRp

b248L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNpcmN1bGF0aW9uPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yMTUyLTIxNTk8L3BhZ2VzPjx2b2x1bWU+MTIy

PC92b2x1bWU+PG51bWJlcj4yMTwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8

L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBDb21iaW5lZCBNb2RhbGl0

eSBUaGVyYXB5IERlYXRoLFN1ZGRlbixDYXJkaWFjL2VwIFtFcGlkZW1pb2xvZ3ldICpEZWF0aCxT

dWRkZW4sQ2FyZGlhYy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSAqRmF0dHkgQWNpZHMs

T21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVn

YS0zL2FlIFtBZHZlcnNlIEVmZmVjdHNdIEZlbWFsZSBGb2xsb3ctVXAgU3R1ZGllcyBGb29kIEhh

Yml0cyBIdW08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2Rh

dGVzPjxpc2JuPjE1MjQtNDUzOTwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEw

LjExNjEvQ0lSQ1VMQVRJT05BSEEuMTEwLjk0ODU2MjtNdWx0aWNlbnRlciBTdHVkeSBSYW5kb21p

emVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkNSZhbXA7QU49MjEwNjAwNzFodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9j

YWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMTA2MDA3MSZhbXA7aWQ9ZG9pOjEwLjEx

NjElMkZDSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyJmFtcDtpc3NuPTAwMDktNzMyMiZhbXA7aXNi

bj0mYW1wO3ZvbHVtZT0xMjImYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMTUyJmFtcDtwYWdlcz0y

MTUyLTkmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Q2lyY3VsYXRpb24mYW1wO2F0aXRsZT1PTUVH

QSUyQythK3JhbmRvbWl6ZWQlMkMrcGxhY2Viby1jb250cm9sbGVkK3RyaWFsK3RvK3Rlc3QrdGhl

K2VmZmVjdCtvZitoaWdobHkrcHVyaWZpZWQrb21lZ2EtMytmYXR0eSthY2lkcytvbit0b3Arb2Yr

bW9kZXJuK2d1aWRlbGluZS1hZGp1c3RlZCt0aGVyYXB5K2FmdGVyK215b2NhcmRpYWwraW5mYXJj

dGlvbi4mYW1wO2F1bGFzdD1SYXVjaDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (10)) and General Health Questionnaire (GHQ-30, ≥5PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYW5nb3VyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

UmVjTnVtPjM1MDc8L1JlY051bT48RGlzcGxheVRleHQ+KDExKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4zNTA3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTEzNDgiPjM1MDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkRhbmdvdXIsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5BbGxlbiwgRS48L2F1dGhvcj48YXV0aG9y

PkVsYm91cm5lLCBELjwvYXV0aG9yPjxhdXRob3I+RmFzZXksIE4uPC9hdXRob3I+PGF1dGhvcj5G

bGV0Y2hlciwgQS4gRS48L2F1dGhvcj48YXV0aG9yPkhhcmR5LCBQLjwvYXV0aG9yPjxhdXRob3I+

SG9sZGVyLCBHLiBFLjwvYXV0aG9yPjxhdXRob3I+S25pZ2h0LCBSLjwvYXV0aG9yPjxhdXRob3I+

TGV0bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHMsIE0uPC9hdXRob3I+PGF1dGhvcj5V

YXV5LCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRh

bmdvdXIsQWxhbiBELiBMb25kb24gU2Nob29sIG9mIEh5Z2llbmUgYW5kIFRyb3BpY2FsIE1lZGlj

aW5lLCBVbml0ZWQgS2luZ2RvbS4gYWxhbi5kYW5nb3VyQGxzaHRtLmFjLnVrICZsdDthbGFuLmRh

bmdvdXJAbHNodG0uYWMudWsmZ3Q7PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0

IG9mIDIteSBuLTMgbG9uZy1jaGFpbiBwb2x5dW5zYXR1cmF0ZWQgZmF0dHkgYWNpZCBzdXBwbGVt

ZW50YXRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIHBlb3BsZTogYSByYW5kb21p

emVkLCBkb3VibGUtYmxpbmQsIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFtIEogQ2xpbiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2Z1

bGwtdGl0bGU+PGFiYnItMT5BbSBKIENsaW4gTnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIEFtZXJp

Y2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxh

bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51

dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnIt

Mj5UaGUgQW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4xNzI1LTE3MzI8L3BhZ2VzPjx2b2x1bWU+OTE8L3ZvbHVtZT48

bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkNvZ25pdGlvbi9kZSBbRHJ1ZyBFZmZlY3Rz

XSBDb2duaXRpb24vcGggW1BoeXNpb2xvZ3ldIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJs

aW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsg

RG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS0zL2JsIFtCbG9vZF0gRmVtYWxlIEh1bWFucyBNYWxl

IE5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0cyBQYXRpZW50IENvbXBsaWFuY2UgMCAoRmF0dHk8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE5

MzgtMzIwNzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjM5NDUvYWpjbi4y

MDA5LjI5MTIxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDQxMDA4OWh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDEwMDg5

JmFtcDtpZD1kb2k6MTAuMzk0NSUyRmFqY24uMjAwOS4yOTEyMSZhbXA7aXNzbj0wMDAyLTkxNjUm

YW1wO2lzYm49JmFtcDt2b2x1bWU9OTEmYW1wO2lzc3VlPTYmYW1wO3NwYWdlPTE3MjUmYW1wO3Bh

Z2VzPTE3MjUtMzImYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitD

bGluaWNhbCtOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2YrMi15K24tMytsb25nLWNoYWlu

K3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkK3N1cHBsZW1lbnRhdGlvbitvbitjb2duaXRpdmUr

ZnVuY3Rpb24raW4rb2xkZXIrcGVvcGxlJTNBK2ErcmFuZG9taXplZCUyQytkb3VibGUtYmxpbmQl

MkMrY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1EYW5nb3VyPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYW5nb3VyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

UmVjTnVtPjM1MDc8L1JlY051bT48RGlzcGxheVRleHQ+KDExKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4zNTA3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTEzNDgiPjM1MDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkRhbmdvdXIsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5BbGxlbiwgRS48L2F1dGhvcj48YXV0aG9y

PkVsYm91cm5lLCBELjwvYXV0aG9yPjxhdXRob3I+RmFzZXksIE4uPC9hdXRob3I+PGF1dGhvcj5G

bGV0Y2hlciwgQS4gRS48L2F1dGhvcj48YXV0aG9yPkhhcmR5LCBQLjwvYXV0aG9yPjxhdXRob3I+

SG9sZGVyLCBHLiBFLjwvYXV0aG9yPjxhdXRob3I+S25pZ2h0LCBSLjwvYXV0aG9yPjxhdXRob3I+

TGV0bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHMsIE0uPC9hdXRob3I+PGF1dGhvcj5V

YXV5LCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRh

bmdvdXIsQWxhbiBELiBMb25kb24gU2Nob29sIG9mIEh5Z2llbmUgYW5kIFRyb3BpY2FsIE1lZGlj

aW5lLCBVbml0ZWQgS2luZ2RvbS4gYWxhbi5kYW5nb3VyQGxzaHRtLmFjLnVrICZsdDthbGFuLmRh

bmdvdXJAbHNodG0uYWMudWsmZ3Q7PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0

IG9mIDIteSBuLTMgbG9uZy1jaGFpbiBwb2x5dW5zYXR1cmF0ZWQgZmF0dHkgYWNpZCBzdXBwbGVt

ZW50YXRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIHBlb3BsZTogYSByYW5kb21p

emVkLCBkb3VibGUtYmxpbmQsIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFtIEogQ2xpbiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2Z1

bGwtdGl0bGU+PGFiYnItMT5BbSBKIENsaW4gTnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIEFtZXJp

Y2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxh

bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51

dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnIt

Mj5UaGUgQW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4xNzI1LTE3MzI8L3BhZ2VzPjx2b2x1bWU+OTE8L3ZvbHVtZT48

bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkNvZ25pdGlvbi9kZSBbRHJ1ZyBFZmZlY3Rz

XSBDb2duaXRpb24vcGggW1BoeXNpb2xvZ3ldIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJs

aW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsg

RG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS0zL2JsIFtCbG9vZF0gRmVtYWxlIEh1bWFucyBNYWxl

IE5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0cyBQYXRpZW50IENvbXBsaWFuY2UgMCAoRmF0dHk8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE5

MzgtMzIwNzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjM5NDUvYWpjbi4y

MDA5LjI5MTIxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDQxMDA4OWh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDEwMDg5

JmFtcDtpZD1kb2k6MTAuMzk0NSUyRmFqY24uMjAwOS4yOTEyMSZhbXA7aXNzbj0wMDAyLTkxNjUm

YW1wO2lzYm49JmFtcDt2b2x1bWU9OTEmYW1wO2lzc3VlPTYmYW1wO3NwYWdlPTE3MjUmYW1wO3Bh

Z2VzPTE3MjUtMzImYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitD

bGluaWNhbCtOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2YrMi15K24tMytsb25nLWNoYWlu

K3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkK3N1cHBsZW1lbnRhdGlvbitvbitjb2duaXRpdmUr

ZnVuY3Rpb24raW4rb2xkZXIrcGVvcGxlJTNBK2ErcmFuZG9taXplZCUyQytkb3VibGUtYmxpbmQl

MkMrY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1EYW5nb3VyPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (11)). In these three trials the median LCn3 dose was 0.85g/d (range 0.4 to 1.0) and the median duration was 40 months (range 12 to 60 months). In other trials diagnosis resulted from Geriatric Depression scores (GDS-15, >10), reported adverse events or were unclear. There was no suggestion of publication bias in visual inspection of the funnel plot (Supplementary Figure 5) or using statistical tests (Harbord test p=0.27 , Peters test p=0.29) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXJib3JkPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48

UmVjTnVtPjIyMTkxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigzNi0zOCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjIxOTE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTU2ODAyOTQ2MiI+MjIxOTE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkhhcmJvcmQsIFJvZ2VyIE0uPC9hdXRob3I+PGF1dGhvcj5FZ2dlciwgTWF0dGhpYXM8

L2F1dGhvcj48YXV0aG9yPlN0ZXJuZSwgSm9uYXRoYW4gQS4gQy48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+QSBtb2RpZmllZCB0ZXN0IGZvciBzbWFsbC1z

dHVkeSBlZmZlY3RzIGluIG1ldGEtYW5hbHlzZXMgb2YgY29udHJvbGxlZCB0cmlhbHMgd2l0aCBi

aW5hcnkgZW5kcG9pbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlN0YXRpc3RpY3MgaW4gTWVk

aWNpbmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5T

dGF0aXN0aWNzIGluIE1lZGljaW5lPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MzQ0

My0zNDU3PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4yMDwvbnVtYmVyPjxkYXRl

cz48eWVhcj4yMDA2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MDI3Ny02NzE1PC9pc2JuPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwczovL29ubGluZWxpYnJhcnkud2lsZXkuY29tL2RvaS9hYnMv

MTAuMTAwMi9zaW0uMjM4MDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+RE9JOiAxMC4xMDAyL3NpbS4yMzgwPC9lbGVjdHJvbmljLXJlc291cmNlLW51

bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TdGVybmU8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MjIxMDI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIyMTAyPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZz

czVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NjAxODE2MTUiPjIyMTAyPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TdGVybmUsIEpvbmF0aGFuIEEg

QzwvYXV0aG9yPjxhdXRob3I+U3V0dG9uLCBBbGV4IEo8L2F1dGhvcj48YXV0aG9yPklvYW5uaWRp

cywgSm9obiBQIEE8L2F1dGhvcj48YXV0aG9yPlRlcnJpbiwgTm9ybWE8L2F1dGhvcj48YXV0aG9y

PkpvbmVzLCBEYXZpZCBSPC9hdXRob3I+PGF1dGhvcj5MYXUsIEpvc2VwaDwvYXV0aG9yPjxhdXRo

b3I+Q2FycGVudGVyLCBKYW1lczwvYXV0aG9yPjxhdXRob3I+UsO8Y2tlciwgR2VydGE8L2F1dGhv

cj48YXV0aG9yPkhhcmJvcmQsIFJvZ2VyIE08L2F1dGhvcj48YXV0aG9yPlNjaG1pZCwgQ2hyaXN0

b3BoZXIgSDwvYXV0aG9yPjxhdXRob3I+VGV0emxhZmYsIEplbm5pZmVyPC9hdXRob3I+PGF1dGhv

cj5EZWVrcywgSm9uYXRoYW4gSjwvYXV0aG9yPjxhdXRob3I+UGV0ZXJzLCBKYWltZTwvYXV0aG9y

PjxhdXRob3I+TWFjYXNraWxsLCBQZXRyYTwvYXV0aG9yPjxhdXRob3I+U2Nod2FyemVyLCBHdWlk

bzwvYXV0aG9yPjxhdXRob3I+RHV2YWwsIFN1ZTwvYXV0aG9yPjxhdXRob3I+QWx0bWFuLCBEb3Vn

bGFzIEc8L2F1dGhvcj48YXV0aG9yPk1vaGVyLCBEYXZpZDwvYXV0aG9yPjxhdXRob3I+SGlnZ2lu

cywgSnVsaWFuIFAgVDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT5SZWNvbW1lbmRhdGlvbnMgZm9yIGV4YW1pbmluZyBhbmQgaW50ZXJwcmV0aW5nIGZ1bm5l

bCBwbG90IGFzeW1tZXRyeSBpbiBtZXRhLWFuYWx5c2VzIG9mIHJhbmRvbWlzZWQgY29udHJvbGxl

ZCB0cmlhbHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1KPC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBNZWRpY2FsIEpvdXJuYWw8L2Z1

bGwtdGl0bGU+PGFiYnItMT5CciBNZWQgSjwvYWJici0xPjxhYmJyLTI+Qk1KPC9hYmJyLTI+PGFi

YnItMz5CbWo8L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPmQ0MDAyPC9wYWdlcz48dm9sdW1l

PjM0Mzwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3LmJtai5jb20vY29udGVudC9ibWovMzQzL2Jtai5kNDAw

Mi5mdWxsLnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+RE9JOiAxMC4xMTM2L2Jtai5kNDAwMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+UGV0ZXJzPC9BdXRob3I+PFllYXI+MjAwNjwvWWVh

cj48UmVjTnVtPjIyMTkzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMjE5MzwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVl

MGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTY4MDM5MTQyIj4yMjE5Mzwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGV0ZXJzLCBKYWltZSBMLjwvYXV0aG9y

PjxhdXRob3I+U3V0dG9uLCBBbGV4IEouPC9hdXRob3I+PGF1dGhvcj5Kb25lcywgRGF2aWQgUi48

L2F1dGhvcj48YXV0aG9yPkFicmFtcywgS2VpdGggUi48L2F1dGhvcj48YXV0aG9yPlJ1c2h0b24s

IExlc2xleTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5D

b21wYXJpc29uIG9mIFR3byBNZXRob2RzIHRvIERldGVjdCBQdWJsaWNhdGlvbiBCaWFzIGluIE1l

dGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFt

ZXJpY2FuIE1lZGljYWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxwYWdlcz42NzYtNjgwPC9wYWdlcz48dm9sdW1lPjI5NTwvdm9sdW1l

PjxudW1iZXI+NjwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+

MDA5OC03NDg0PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL2RvaS5vcmcv

MTAuMTAwMS9qYW1hLjI5NS42LjY3NjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+RE9JOiAxMC4xMDAxL2phbWEuMjk1LjYuNjc2PC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48YWNjZXNzLWRhdGU+OS85LzIwMTk8L2FjY2Vzcy1kYXRlPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXJib3JkPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48

UmVjTnVtPjIyMTkxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigzNi0zOCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjIxOTE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTU2ODAyOTQ2MiI+MjIxOTE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkhhcmJvcmQsIFJvZ2VyIE0uPC9hdXRob3I+PGF1dGhvcj5FZ2dlciwgTWF0dGhpYXM8

L2F1dGhvcj48YXV0aG9yPlN0ZXJuZSwgSm9uYXRoYW4gQS4gQy48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+QSBtb2RpZmllZCB0ZXN0IGZvciBzbWFsbC1z

dHVkeSBlZmZlY3RzIGluIG1ldGEtYW5hbHlzZXMgb2YgY29udHJvbGxlZCB0cmlhbHMgd2l0aCBi

aW5hcnkgZW5kcG9pbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlN0YXRpc3RpY3MgaW4gTWVk

aWNpbmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5T

dGF0aXN0aWNzIGluIE1lZGljaW5lPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MzQ0

My0zNDU3PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4yMDwvbnVtYmVyPjxkYXRl

cz48eWVhcj4yMDA2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MDI3Ny02NzE1PC9pc2JuPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwczovL29ubGluZWxpYnJhcnkud2lsZXkuY29tL2RvaS9hYnMv

MTAuMTAwMi9zaW0uMjM4MDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+RE9JOiAxMC4xMDAyL3NpbS4yMzgwPC9lbGVjdHJvbmljLXJlc291cmNlLW51

bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TdGVybmU8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MjIxMDI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIyMTAyPC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZz

czVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NjAxODE2MTUiPjIyMTAyPC9r

ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl

Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TdGVybmUsIEpvbmF0aGFuIEEg

QzwvYXV0aG9yPjxhdXRob3I+U3V0dG9uLCBBbGV4IEo8L2F1dGhvcj48YXV0aG9yPklvYW5uaWRp

cywgSm9obiBQIEE8L2F1dGhvcj48YXV0aG9yPlRlcnJpbiwgTm9ybWE8L2F1dGhvcj48YXV0aG9y

PkpvbmVzLCBEYXZpZCBSPC9hdXRob3I+PGF1dGhvcj5MYXUsIEpvc2VwaDwvYXV0aG9yPjxhdXRo

b3I+Q2FycGVudGVyLCBKYW1lczwvYXV0aG9yPjxhdXRob3I+UsO8Y2tlciwgR2VydGE8L2F1dGhv

cj48YXV0aG9yPkhhcmJvcmQsIFJvZ2VyIE08L2F1dGhvcj48YXV0aG9yPlNjaG1pZCwgQ2hyaXN0

b3BoZXIgSDwvYXV0aG9yPjxhdXRob3I+VGV0emxhZmYsIEplbm5pZmVyPC9hdXRob3I+PGF1dGhv

cj5EZWVrcywgSm9uYXRoYW4gSjwvYXV0aG9yPjxhdXRob3I+UGV0ZXJzLCBKYWltZTwvYXV0aG9y

PjxhdXRob3I+TWFjYXNraWxsLCBQZXRyYTwvYXV0aG9yPjxhdXRob3I+U2Nod2FyemVyLCBHdWlk

bzwvYXV0aG9yPjxhdXRob3I+RHV2YWwsIFN1ZTwvYXV0aG9yPjxhdXRob3I+QWx0bWFuLCBEb3Vn

bGFzIEc8L2F1dGhvcj48YXV0aG9yPk1vaGVyLCBEYXZpZDwvYXV0aG9yPjxhdXRob3I+SGlnZ2lu

cywgSnVsaWFuIFAgVDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT5SZWNvbW1lbmRhdGlvbnMgZm9yIGV4YW1pbmluZyBhbmQgaW50ZXJwcmV0aW5nIGZ1bm5l

bCBwbG90IGFzeW1tZXRyeSBpbiBtZXRhLWFuYWx5c2VzIG9mIHJhbmRvbWlzZWQgY29udHJvbGxl

ZCB0cmlhbHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1KPC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBNZWRpY2FsIEpvdXJuYWw8L2Z1

bGwtdGl0bGU+PGFiYnItMT5CciBNZWQgSjwvYWJici0xPjxhYmJyLTI+Qk1KPC9hYmJyLTI+PGFi

YnItMz5CbWo8L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPmQ0MDAyPC9wYWdlcz48dm9sdW1l

PjM0Mzwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PHVybHM+PHJlbGF0

ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3LmJtai5jb20vY29udGVudC9ibWovMzQzL2Jtai5kNDAw

Mi5mdWxsLnBkZjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+RE9JOiAxMC4xMTM2L2Jtai5kNDAwMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+UGV0ZXJzPC9BdXRob3I+PFllYXI+MjAwNjwvWWVh

cj48UmVjTnVtPjIyMTkzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMjE5MzwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVl

MGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTY4MDM5MTQyIj4yMjE5Mzwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGV0ZXJzLCBKYWltZSBMLjwvYXV0aG9y

PjxhdXRob3I+U3V0dG9uLCBBbGV4IEouPC9hdXRob3I+PGF1dGhvcj5Kb25lcywgRGF2aWQgUi48

L2F1dGhvcj48YXV0aG9yPkFicmFtcywgS2VpdGggUi48L2F1dGhvcj48YXV0aG9yPlJ1c2h0b24s

IExlc2xleTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5D

b21wYXJpc29uIG9mIFR3byBNZXRob2RzIHRvIERldGVjdCBQdWJsaWNhdGlvbiBCaWFzIGluIE1l

dGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25kYXJ5LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFt

ZXJpY2FuIE1lZGljYWwgQXNzb2NpYXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxwYWdlcz42NzYtNjgwPC9wYWdlcz48dm9sdW1lPjI5NTwvdm9sdW1l

PjxudW1iZXI+NjwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+

MDA5OC03NDg0PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL2RvaS5vcmcv

MTAuMTAwMS9qYW1hLjI5NS42LjY3NjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+RE9JOiAxMC4xMDAxL2phbWEuMjk1LjYuNjc2PC9lbGVjdHJvbmlj

LXJlc291cmNlLW51bT48YWNjZXNzLWRhdGU+OS85LzIwMTk8L2FjY2Vzcy1kYXRlPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (36-38). Similarly there were no clearly missing data (although several of the ongoing trials detailed in Supplementary Table 10 would be expected to have finished by the start of 2017, so might be considered to constitute missing data, non-publication is most likely to equate to minimal effect sizes so would be likely to confirm rather than change our findings). The similarity of the random- and fixed-effects meta-analyses, which weight small studies differently (random effects: RR 1.01, 95% CI 0.92 to 1.10; fixed-effects: RR 1.02, 95% CI 0.93 to 1.12) also suggest that little small study bias is present. ADDIN EN.CITE <EndNote><Cite><Author>Page</Author><Year>2019</Year><RecNum>22162</RecNum><DisplayText>(39)</DisplayText><record><rec-number>22162</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1565082516">22162</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Page, M.J.</author><author>Higgins, J. P. T.</author><author>Sterne, J. A. C.</author></authors><secondary-authors><author>HIggins, J.P.T.</author><author>Thomas, J.</author><author>Chandler, J.</author><author>Cumpston, M.</author><author>Li, T.</author><author>Page, M. J.</author><author>Welch, V. A. </author></secondary-authors></contributors><titles><title>Chapter 13: Assessing risk of bias due to missing results in a synthesis. Draft version (29 Janaury 2019) for inclusion in</title><secondary-title>Cochrane Handbook for Systematic Reviews of Interventions</secondary-title></titles><dates><year>2019</year></dates><pub-location>London</pub-location><publisher>Cochrane</publisher><urls></urls></record></Cite></EndNote>(39) Subgrouping by intervention type, replacement nutrients, and LCn3 dose did not suggest important differences by subgroup, but subgrouping by baseline depression risk suggested increased depression risk in healthy adults with increased LCn3, and little or no effect in those with serious illnesses (no trials recruited participants with current depression or where ≥50% took antidepressants, Supplementary Table 2). As pre-specified LCn3 dose subgroupings did not divide included trials effectively, post-hoc we re-ran more even LCn3 dose subgroupings, and subgroupings by EPA and DHA dose. There was no suggestion of LCn3 dose effects (test for subgroup differences p=0.98), EPA (p=0.13) or DHA (p=0.87) effects, Supplementary Figures 2-4. GRADE assessment suggests that increasing LCn3 probably has little or no effect on risk of depression symptoms (moderate-quality evidence, downgraded once for imprecision, Supplementary Table 3).Data were very limited from trials of ALA (RR 1.11, 95% CI 0.67 to 1.84, 1 trial, 59 people found to have depression symptoms (GDS-15 score >10), not altered in any sensitivity analysis, ALA dose 2g/d, trial duration 40 months, Figure 2 and Supplementary Table 4) and total PUFA (RR 0.75, 95% CI 0.54 to 1.03, 1 trial, 147 depression diagnoses – assessed via diagnosis by usual physician and reported by participants at study follow-up or reported habitual use of antidepressant drugs, total PUFA dose unclear, median duration 56 months, Figure 2 and Supplementary Table 5), and we found no data from trials of omega-6 (Figure 2). GRADE suggests that increasing ALA may increase the risk of depression symptoms very slightly (NNH 1000, low-quality evidence, downgraded twice for imprecision) and effects of increasing total PUFA on risk of depression symptoms are unclear as the evidence is of very low-quality (downgraded once each for risk of bias, indirectness and inconsistency, Supplementary Tables 6 and 7).Depression severity and remission (in those with existing depression). A single small trial assessed effects of 1.1g/d LCn3 for 6 months in poor Iranian men with mild or moderate depression symptoms at baseline (GDS-15 mean 7.2).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MTU2ODU8L1JlY051bT48RGlzcGxheVRleHQ+KDMxKTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNTY4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4MjE1Ij4xNTY4NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VGFqYWxpemFkZWtob29iLCBZLjwvYXV0aG9yPjxhdXRob3I+U2hhcmlmaSwg

Ri48L2F1dGhvcj48YXV0aG9yPkZha2hyemFkZWgsIEguPC9hdXRob3I+PGF1dGhvcj5NaXJhcmVm

aW4sIE0uPC9hdXRob3I+PGF1dGhvcj5HaGFkZXJwYW5haGksIE0uPC9hdXRob3I+PGF1dGhvcj5C

YWRhbWNoaXphZGUsIFouPC9hdXRob3I+PGF1dGhvcj5BemltaXBvdXIsIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGFqYWxpemFkZWtob29iLFlhc2Vy

LiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtIFJlc2VhcmNoIENlbnRlciwgVGVocmFuIFVu

aXZlcnNpdHkgb2YgTWVkaWNhbCBTY2llbmNlcywgNXRoIGZsb29yLCBEciBTaGFyZWVhdGkgSG9z

cGl0YWwsIE5vcnRoIEthcmVnYXIgQXZlbnVlLCBUZWhyYW4sIElyYW48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0IG9mIGxvdy1kb3NlIG9tZWdhIDMgZmF0dHkgYWNpZHMg

b24gdGhlIHRyZWF0bWVudCBvZiBtaWxkIHRvIG1vZGVyYXRlIGRlcHJlc3Npb24gaW4gdGhlIGVs

ZGVybHk6IGEgZG91YmxlLWJsaW5kLCByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRy

eSAmYW1wOyBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0cnkgJmFt

cDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFyY2ggUHN5

Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNoaXZlcyBv

ZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNo

aWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy

IEFyY2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBB

cmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MzktNTQ5PC9wYWdlcz48dm9sdW1lPjI2MTwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFudGlkZXBy

ZXNzaXZlIEFnZW50cy90dSBbVGhlcmFwZXV0aWMgVXNlXSAqRGVwcmVzc2lvbi9kdCBbRHJ1ZyBU

aGVyYXB5XSBEaWV0IERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBIeXBlcnNlbnNpdGl2aXR5IEZh

dHR5IEFjaWRzLE9tZWdhLTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkZhdHR5IEFjaWRzLE9tZWdh

LTMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRmVtYWxlIEZpc2ggT2lscy9hZCBbQWRtaW5pPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PC9kYXRlcz48aXNibj4xNDMz

LTg0OTE8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MwMDQwNi0w

MTEtMDE5MS05O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTMxODQ1Mmh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMzE4NDUy

JmFtcDtpZD1kb2k6MTAuMTAwNyUyRnMwMDQwNi0wMTEtMDE5MS05JmFtcDtpc3NuPTA5NDAtMTMz

NCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNjEmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTUzOSZhbXA7

cGFnZXM9NTM5LTQ5JmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUV1cm9wZWFuK0FyY2hpdmVzK29m

K1BzeWNoaWF0cnkrJTI2K0NsaW5pY2FsK05ldXJvc2NpZW5jZSZhbXA7YXRpdGxlPVRoZStlZmZl

Y3Qrb2YrbG93LWRvc2Urb21lZ2ErMytmYXR0eSthY2lkcytvbit0aGUrdHJlYXRtZW50K29mK21p

bGQrdG8rbW9kZXJhdGUrZGVwcmVzc2lvbitpbit0aGUrZWxkZXJseSUzQSthK2RvdWJsZS1ibGlu

ZCUyQytyYW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCtzdHVkeS4mYW1wO2F1bGFzdD1U

YWphbGl6YWRla2hvb2I8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MTU2ODU8L1JlY051bT48RGlzcGxheVRleHQ+KDMxKTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNTY4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4MjE1Ij4xNTY4NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VGFqYWxpemFkZWtob29iLCBZLjwvYXV0aG9yPjxhdXRob3I+U2hhcmlmaSwg

Ri48L2F1dGhvcj48YXV0aG9yPkZha2hyemFkZWgsIEguPC9hdXRob3I+PGF1dGhvcj5NaXJhcmVm

aW4sIE0uPC9hdXRob3I+PGF1dGhvcj5HaGFkZXJwYW5haGksIE0uPC9hdXRob3I+PGF1dGhvcj5C

YWRhbWNoaXphZGUsIFouPC9hdXRob3I+PGF1dGhvcj5BemltaXBvdXIsIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGFqYWxpemFkZWtob29iLFlhc2Vy

LiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtIFJlc2VhcmNoIENlbnRlciwgVGVocmFuIFVu

aXZlcnNpdHkgb2YgTWVkaWNhbCBTY2llbmNlcywgNXRoIGZsb29yLCBEciBTaGFyZWVhdGkgSG9z

cGl0YWwsIE5vcnRoIEthcmVnYXIgQXZlbnVlLCBUZWhyYW4sIElyYW48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0IG9mIGxvdy1kb3NlIG9tZWdhIDMgZmF0dHkgYWNpZHMg

b24gdGhlIHRyZWF0bWVudCBvZiBtaWxkIHRvIG1vZGVyYXRlIGRlcHJlc3Npb24gaW4gdGhlIGVs

ZGVybHk6IGEgZG91YmxlLWJsaW5kLCByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRy

eSAmYW1wOyBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0cnkgJmFt

cDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFyY2ggUHN5

Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNoaXZlcyBv

ZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNo

aWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy

IEFyY2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBB

cmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MzktNTQ5PC9wYWdlcz48dm9sdW1lPjI2MTwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFudGlkZXBy

ZXNzaXZlIEFnZW50cy90dSBbVGhlcmFwZXV0aWMgVXNlXSAqRGVwcmVzc2lvbi9kdCBbRHJ1ZyBU

aGVyYXB5XSBEaWV0IERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBIeXBlcnNlbnNpdGl2aXR5IEZh

dHR5IEFjaWRzLE9tZWdhLTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkZhdHR5IEFjaWRzLE9tZWdh

LTMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRmVtYWxlIEZpc2ggT2lscy9hZCBbQWRtaW5pPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PC9kYXRlcz48aXNibj4xNDMz

LTg0OTE8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MwMDQwNi0w

MTEtMDE5MS05O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTMxODQ1Mmh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMzE4NDUy

JmFtcDtpZD1kb2k6MTAuMTAwNyUyRnMwMDQwNi0wMTEtMDE5MS05JmFtcDtpc3NuPTA5NDAtMTMz

NCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNjEmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTUzOSZhbXA7

cGFnZXM9NTM5LTQ5JmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUV1cm9wZWFuK0FyY2hpdmVzK29m

K1BzeWNoaWF0cnkrJTI2K0NsaW5pY2FsK05ldXJvc2NpZW5jZSZhbXA7YXRpdGxlPVRoZStlZmZl

Y3Qrb2YrbG93LWRvc2Urb21lZ2ErMytmYXR0eSthY2lkcytvbit0aGUrdHJlYXRtZW50K29mK21p

bGQrdG8rbW9kZXJhdGUrZGVwcmVzc2lvbitpbit0aGUrZWxkZXJseSUzQSthK2RvdWJsZS1ibGlu

ZCUyQytyYW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCtzdHVkeS4mYW1wO2F1bGFzdD1U

YWphbGl6YWRla2hvb2I8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (31) The study was not at low summary risk of bias, and found that GDS score fell by >10% of baseline, suggesting reduced severity of depression, in the higher LCn3 arm compared to control (MD -0.94, 95% CI -2.27 to 0.39, 61 participants) over 6 months. A further small study included participants with Parkinson’s DiseasePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb21wb25pPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjEyNzYxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyOSk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTI3NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFt

cD0iMTUzMDIxNjUzMiI+MTI3NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPlBvbXBvbmksIE0uPC9hdXRob3I+PGF1dGhvcj5Mb3JpYSwgRy48L2F1dGhvcj48YXV0aG9y

PlNhbHZhdGksIFMuPC9hdXRob3I+PGF1dGhvcj5EaSBCaWFzZSwgQS48L2F1dGhvcj48YXV0aG9y

PkNvbnRlLCBHLjwvYXV0aG9yPjxhdXRob3I+VmlsbGVsbGEsIEMuPC9hdXRob3I+PGF1dGhvcj5S

aWdoaW5vLCBFLjwvYXV0aG9yPjxhdXRob3I+Q2ljaWFyZWxsaSwgQy48L2F1dGhvcj48YXV0aG9y

PkJyaWEsIFAuPC9hdXRob3I+PGF1dGhvcj5MYSBUb3JyZSwgRy48L2F1dGhvcj48YXV0aG9yPlBv

bXBvbmksIE0uIEYuIEwuPC9hdXRob3I+PGF1dGhvcj5KYW5pcmksIEwuPC9hdXRob3I+PGF1dGhv

cj5CZW50aXZvZ2xpbywgQS4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz4oUG9tcG9uaSwgQ29udGUsIFZpbGxlbGxhLCBSaWdoaW5vLCBDaWNpYXJlbGxp

LCBCcmlhLCBKYW5pcmkpIEluc3RpdHV0ZSBvZiBQc3ljaGlhdHJ5LCBEZXBhcnRtZW50IG9mIEdl

cmlhdHJpY3MsIE5ldXJvc2NpZW5jZSBhbmQgT3J0aG9wYWVkaWNzLCBVbml2ZXJzaXRhIENhdHRv

bGljYSBkZWwgU2Fjcm8gQ3VvcmUgKFVDU0MpLCBSb21hLCBJdGFseSAoUG9tcG9uaSkgQ2VudHJv

IFN0dWRpIEFjaGlsbGUgZSBMaW5kYSBMb3JlbnpvbiwgVHJldmlzbywgSXRhbHkgKExvcmlhLCBC

ZW50aXZvZ2xpbykgSW5zdGl0dXRlIG9mIE5ldXJvbG9neSwgVUNTQywgUm9tYSwgSXRhbHkgKFNh

bHZhdGksIERpIEJpYXNlKSBJc3RpdHV0byBTdXBlcmlvcmUgZGkgU2FuaXRhLCBSb21hLCBJdGFs

eSAoTGEgVG9ycmUpIERlcGFydG1lbnQgb2YgUHVibGljIEhlYWx0aCBhbmQgSW5mZWN0aW91cyBE

aXNlYXNlcywgTGEgU2FwaWVuemEgVW5pdmVyc2l0eSwgUm9tYSwgSXRhbHkgKFBvbXBvbmkpIElu

c3RpdHV0ZSBvZiBCaW9jaGVtaXN0cnkgYW5kIENsaW5pY2FsIEJpb2NoZW1pc3RyeSwgVUNTQywg

Um9tYSwgSXRhbHkgTS4gUG9tcG9uaSwgSW5zdGl0dXRlIG9mIFBzeWNoaWF0cnksIERlcGFydG1l

bnQgb2YgR2VyaWF0cmljcywgTmV1cm9zY2llbmNlIGFuZCBPcnRob3BhZWRpY3MsIFVuaXZlcnNp

dGEgQ2F0dG9saWNhIGRlbCBTYWNybyBDdW9yZSAoVUNTQyksIFJvbWEsIEl0YWx5LiBFLW1haWw6

IG1hc3NpbWlsaWFub3BvbXBvbmlAYWxpY2UuaXQ8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5ESEEgZWZmZWN0cyBpbiBQYXJraW5zb24gZGlzZWFzZSBkZXByZXNzaW9uPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkJhc2FsIEdhbmdsaWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5CYXNhbCBHYW5nbGlhPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh

bD48cGFnZXM+NjEtNjY8L3BhZ2VzPjx2b2x1bWU+NDwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVy

PjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+

PGtleXdvcmQ+RGVwcmVzc2lvbiBEb2Nvc2FoZXhhZW5vaWMgYWNpZCBQYXJraW5zb24mYXBvcztz

IGRpc2Vhc2UgYWR1bHQgYW5oZWRvbmlhIGFueGlldHkgYXBhdGh5IGFydGljbGUgY2xpbmljYWwg

YXJ0aWNsZSBjbGluaWNhbCBlZmZlY3RpdmVuZXNzIGNvbnRyb2xsZWQgc3R1ZHkgZGVwcmVzc2lv

bi9kdCBbRHJ1ZyBUaGVyYXB5XSBkaXNlYXNlIGFzc29jaWF0aW9uIGRvdWJsZSBibGluZCBwcm9j

ZWR1cmUgZHJ1ZyBlZmZlY3QgZmF0dHkgYWNpZCBibG9vZCBsZXZlPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48aXNibj4yMjEwLTUzMzY8L2lzYm4+

PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYmFnYS4yMDE0LjAzLjAwNDwv

d29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3LmVsc2V2aWVyLmNv

bS93cHMvZmluZC9qb3VybmFsZGVzY3JpcHRpb24uY3dzX2hvbWUvNzI1NDIzL2Rlc2NyaXB0aW9u

I2Rlc2NyaXB0aW9uaHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMiZhbXA7QU49MjAx

NDM4MDc2NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDplbWJhc2UmYW1w

O2lkPXBtaWQ6JmFtcDtpZD1kb2k6MTAuMTAxNiUyRmouYmFnYS4yMDE0LjAzLjAwNCZhbXA7aXNz

bj0yMjEwLTUzMzYmYW1wO2lzYm49JmFtcDt2b2x1bWU9NCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9

NjEmYW1wO3BhZ2VzPTYxLTY2JmFtcDtkYXRlPTIwMTQmYW1wO3RpdGxlPUJhc2FsK0dhbmdsaWEm

YW1wO2F0aXRsZT1ESEErZWZmZWN0cytpbitQYXJraW5zb24rZGlzZWFzZStkZXByZXNzaW9uJmFt

cDthdWxhc3Q9UG9tcG9uaTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb21wb25pPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjEyNzYxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyOSk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTI3NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFt

cD0iMTUzMDIxNjUzMiI+MTI3NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPlBvbXBvbmksIE0uPC9hdXRob3I+PGF1dGhvcj5Mb3JpYSwgRy48L2F1dGhvcj48YXV0aG9y

PlNhbHZhdGksIFMuPC9hdXRob3I+PGF1dGhvcj5EaSBCaWFzZSwgQS48L2F1dGhvcj48YXV0aG9y

PkNvbnRlLCBHLjwvYXV0aG9yPjxhdXRob3I+VmlsbGVsbGEsIEMuPC9hdXRob3I+PGF1dGhvcj5S

aWdoaW5vLCBFLjwvYXV0aG9yPjxhdXRob3I+Q2ljaWFyZWxsaSwgQy48L2F1dGhvcj48YXV0aG9y

PkJyaWEsIFAuPC9hdXRob3I+PGF1dGhvcj5MYSBUb3JyZSwgRy48L2F1dGhvcj48YXV0aG9yPlBv

bXBvbmksIE0uIEYuIEwuPC9hdXRob3I+PGF1dGhvcj5KYW5pcmksIEwuPC9hdXRob3I+PGF1dGhv

cj5CZW50aXZvZ2xpbywgQS4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz4oUG9tcG9uaSwgQ29udGUsIFZpbGxlbGxhLCBSaWdoaW5vLCBDaWNpYXJlbGxp

LCBCcmlhLCBKYW5pcmkpIEluc3RpdHV0ZSBvZiBQc3ljaGlhdHJ5LCBEZXBhcnRtZW50IG9mIEdl

cmlhdHJpY3MsIE5ldXJvc2NpZW5jZSBhbmQgT3J0aG9wYWVkaWNzLCBVbml2ZXJzaXRhIENhdHRv

bGljYSBkZWwgU2Fjcm8gQ3VvcmUgKFVDU0MpLCBSb21hLCBJdGFseSAoUG9tcG9uaSkgQ2VudHJv

IFN0dWRpIEFjaGlsbGUgZSBMaW5kYSBMb3JlbnpvbiwgVHJldmlzbywgSXRhbHkgKExvcmlhLCBC

ZW50aXZvZ2xpbykgSW5zdGl0dXRlIG9mIE5ldXJvbG9neSwgVUNTQywgUm9tYSwgSXRhbHkgKFNh

bHZhdGksIERpIEJpYXNlKSBJc3RpdHV0byBTdXBlcmlvcmUgZGkgU2FuaXRhLCBSb21hLCBJdGFs

eSAoTGEgVG9ycmUpIERlcGFydG1lbnQgb2YgUHVibGljIEhlYWx0aCBhbmQgSW5mZWN0aW91cyBE

aXNlYXNlcywgTGEgU2FwaWVuemEgVW5pdmVyc2l0eSwgUm9tYSwgSXRhbHkgKFBvbXBvbmkpIElu

c3RpdHV0ZSBvZiBCaW9jaGVtaXN0cnkgYW5kIENsaW5pY2FsIEJpb2NoZW1pc3RyeSwgVUNTQywg

Um9tYSwgSXRhbHkgTS4gUG9tcG9uaSwgSW5zdGl0dXRlIG9mIFBzeWNoaWF0cnksIERlcGFydG1l

bnQgb2YgR2VyaWF0cmljcywgTmV1cm9zY2llbmNlIGFuZCBPcnRob3BhZWRpY3MsIFVuaXZlcnNp

dGEgQ2F0dG9saWNhIGRlbCBTYWNybyBDdW9yZSAoVUNTQyksIFJvbWEsIEl0YWx5LiBFLW1haWw6

IG1hc3NpbWlsaWFub3BvbXBvbmlAYWxpY2UuaXQ8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5ESEEgZWZmZWN0cyBpbiBQYXJraW5zb24gZGlzZWFzZSBkZXByZXNzaW9uPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkJhc2FsIEdhbmdsaWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5CYXNhbCBHYW5nbGlhPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh

bD48cGFnZXM+NjEtNjY8L3BhZ2VzPjx2b2x1bWU+NDwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVy

PjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+

PGtleXdvcmQ+RGVwcmVzc2lvbiBEb2Nvc2FoZXhhZW5vaWMgYWNpZCBQYXJraW5zb24mYXBvcztz

IGRpc2Vhc2UgYWR1bHQgYW5oZWRvbmlhIGFueGlldHkgYXBhdGh5IGFydGljbGUgY2xpbmljYWwg

YXJ0aWNsZSBjbGluaWNhbCBlZmZlY3RpdmVuZXNzIGNvbnRyb2xsZWQgc3R1ZHkgZGVwcmVzc2lv

bi9kdCBbRHJ1ZyBUaGVyYXB5XSBkaXNlYXNlIGFzc29jaWF0aW9uIGRvdWJsZSBibGluZCBwcm9j

ZWR1cmUgZHJ1ZyBlZmZlY3QgZmF0dHkgYWNpZCBibG9vZCBsZXZlPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48aXNibj4yMjEwLTUzMzY8L2lzYm4+

PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYmFnYS4yMDE0LjAzLjAwNDwv

d29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3LmVsc2V2aWVyLmNv

bS93cHMvZmluZC9qb3VybmFsZGVzY3JpcHRpb24uY3dzX2hvbWUvNzI1NDIzL2Rlc2NyaXB0aW9u

I2Rlc2NyaXB0aW9uaHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMiZhbXA7QU49MjAx

NDM4MDc2NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDplbWJhc2UmYW1w

O2lkPXBtaWQ6JmFtcDtpZD1kb2k6MTAuMTAxNiUyRmouYmFnYS4yMDE0LjAzLjAwNCZhbXA7aXNz

bj0yMjEwLTUzMzYmYW1wO2lzYm49JmFtcDt2b2x1bWU9NCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9

NjEmYW1wO3BhZ2VzPTYxLTY2JmFtcDtkYXRlPTIwMTQmYW1wO3RpdGxlPUJhc2FsK0dhbmdsaWEm

YW1wO2F0aXRsZT1ESEErZWZmZWN0cytpbitQYXJraW5zb24rZGlzZWFzZStkZXByZXNzaW9uJmFt

cDthdWxhc3Q9UG9tcG9uaTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (29), some of whom were depressed at baseline, and reported on remission, suggesting more remission in those on higher LCn3 (Supplementary Table 2). GRADE assessment suggests that effects of increasing LCn3 on depression severity was unclear as the evidence was of very low-quality (downgraded once each for risk of bias, indirectness and imprecision), and effects of increasing LCn3 on risk of remission in depression is unclear as the evidence was of very low-quality (downgraded once for risk of bias and twice for indirectness, Supplementary Table 3). No trials of ALA, omega-6 or total PUFA included participants with depression at baseline. Depression symptoms assessed on a continuous scale (in those not selected for depression at baseline)Fifteen RCTs assessing depression symptoms on several scales (lower scores indicated less depression) were meta-analysed using SMD suggesting little or no effect of increased LCn3 (SMD 0.01, 95% CI -0.06 to 0.07, I2 46%, mean LCn3 dose 1.2g/d, SD 0.6, median LCn3 dose 1.1g/d, range 0.3 to 2.4g/d, mean trial duration 18 months, SD 21, median duration 6 months, range 6 to 75 months, Supplementary Table 2). In the subgroup of seven trials that assessed depression using the Geriatric Depression Scale (GDS, short form scores from 0 to 15, 0-4 indicating no depression, 5-10 mild depression and 11+ severe depression) the mean difference with increased LCn3 was 0.03 (95% CI -0.10 to 0.16, I2 35%, 8307 participants, mean control group GDS 3.4, mean dose 1.0g/d, SD 0.6, mean duration 17 months, SD 18, median duration 6 months, range 6 to 48 months). There was no effect in any sensitivity analysis, and no differences between subgroups except for subgrouping by duration and depression scale. There was a suggestion of some benefit of LCn3 to depression severity in trials of up to 24 months, no effect in trials of 24 to <48 months, and some harm in trials of at least 48 months. In the single trials using Hamilton, Self-rating and Calgary Depression Scales increasing LCn3 appeared to reduce depression scores (Supplementary Table 2). Post-hoc dose subgrouping using updated cut-offs did not suggest dose effects for LCn3 (test for subgroup differences p=0.36), EPA (p=0.50) or DHA (p=0.23), Supplementary Figures 6-8). There was some evidence of small study bias. Data from two trials PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4xOTg4ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzMsIDQwKTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xOTg4ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMzU1MzY0Ij4xOTg4ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+UmF1Y2gsIEIuPC9hdXRob3I+PGF1dGhvcj5TY2hpZWxlLCBSLjwvYXV0aG9yPjxhdXRo

b3I+U2NobmVpZGVyLCBTLjwvYXV0aG9yPjxhdXRob3I+RGlsbGVyLCBGLjwvYXV0aG9yPjxhdXRo

b3I+VmljdG9yLCBOLjwvYXV0aG9yPjxhdXRob3I+R29obGtlLCBILjwvYXV0aG9yPjxhdXRob3I+

R290dHdpaywgTS48L2F1dGhvcj48YXV0aG9yPlN0ZWluYmVjaywgRy48L2F1dGhvcj48YXV0aG9y

PkRlbCBDYXN0aWxsbywgVS48L2F1dGhvcj48YXV0aG9yPlNhY2ssIFIuPC9hdXRob3I+PGF1dGhv

cj5Xb3J0aCwgSC48L2F1dGhvcj48YXV0aG9yPkthdHVzLCBILjwvYXV0aG9yPjxhdXRob3I+U3Bp

dHplciwgVy48L2F1dGhvcj48YXV0aG9yPlNhYmluLCBHLjwvYXV0aG9yPjxhdXRob3I+U2VuZ2Vz

LCBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5PTUVH

QSwgYSByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgdHJpYWwgdG8gdGVzdCB0aGUgZWZm

ZWN0IG9mIGhpZ2hseSBwdXJpZmllZCBvbWVnYS0zIGZhdHR5IGFjaWRzIG9uIHRvcCBvZiBtb2Rl

cm4gZ3VpZGVsaW5lLWFkanVzdGVkIHRoZXJhcHkgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9u

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmN1bGF0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4yMTUyLTIxNTk8L3BhZ2VzPjx2b2x1bWU+MTIyPC92b2x1bWU+PG51

bWJlcj4yMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91

cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkh1bnRpbmd0b24gU3R1ZHk8L0F1dGhv

cj48WWVhcj4yMDA4PC9ZZWFyPjxSZWNOdW0+NzE0MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i

ZXI+NzE0MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUy

ejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjEzMzY4

Ij43MTQzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IdW50aW5ndG9u

IFN0dWR5IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT5SYW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWwgb2YgZXRoeWwtZWljb3NhcGVudGFlbm9p

YyBhY2lkIGluIEh1bnRpbmd0b24gZGlzZWFzZTogdGhlIFRSRU5ELUhEIHN0dWR5PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+QXJjaCBOZXVyb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BcmNoaXZlcyBvZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoIE5l

dXJvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJj

aGl2ZXMgb2YgTmV1cm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+QXJjaCBOZXVyb2w8L2FiYnIt

MT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNTgyLTE1ODk8L3BhZ2VzPjx2b2x1bWU+NjU8L3Zv

bHVtZT48bnVtYmVyPjEyPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVw

cmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdCBBbmFseXNpcyBvZiBWYXJpYW5j

ZSBDYW5hZGEgRG91YmxlLUJsaW5kIE1ldGhvZCAqRWljb3NhcGVudGFlbm9pYyBBY2lkL2FhIFtB

bmFsb2dzICZhbXA7IERlcml2YXRpdmVzXSBFaWNvc2FwZW50YWVub2ljIEFjaWQvdHUgW1RoZXJh

cGV1dGljIFVzZV0gRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEh1bWFucyAqSHVudGluZ3RvbiBE

aXNlYXNlL2R0IFtEcnVnIFRoZXJhcHldIEh1bnRpbmd0b24gRGlzZWFzZS9nZSBbR2VuZXRpY3Nd

ICpIdTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTUzOC0zNjg3PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAw

MS9hcmNobmV1ci42NS4xMi4xNTgyO0NsaW5pY2FsIFRyaWFsIE11bHRpY2VudGVyIFN0dWR5IFJh

bmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym

YXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Au

b3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1m

dWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xOTA2NDc0NWh0dHA6Ly9zZngudWNsLmFjLnVrL3Nm

eF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE5MDY0NzQ1JmFtcDtpZD1kb2k6

MTAuMTAwMSUyRmFyY2huZXVyLjY1LjEyLjE1ODImYW1wO2lzc249MDAwMy05OTQyJmFtcDtpc2Ju

PSZhbXA7dm9sdW1lPTY1JmFtcDtpc3N1ZT0xMiZhbXA7c3BhZ2U9MTU4MiZhbXA7cGFnZXM9MTU4

Mi05JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPUFyY2hpdmVzK29mK05ldXJvbG9neSZhbXA7YXRp

dGxlPVJhbmRvbWl6ZWQrY29udHJvbGxlZCt0cmlhbCtvZitldGh5bC1laWNvc2FwZW50YWVub2lj

K2FjaWQraW4rSHVudGluZ3RvbitkaXNlYXNlJTNBK3RoZStUUkVORC1IRCtzdHVkeS4mYW1wO2F1

bGFzdD1IdW50aW5ndG9uK1N0dWR5K0dyb3VwK1RSRU5ELUhEPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4xOTg4ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzMsIDQwKTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xOTg4ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMzU1MzY0Ij4xOTg4ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l

PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh

dXRob3I+UmF1Y2gsIEIuPC9hdXRob3I+PGF1dGhvcj5TY2hpZWxlLCBSLjwvYXV0aG9yPjxhdXRo

b3I+U2NobmVpZGVyLCBTLjwvYXV0aG9yPjxhdXRob3I+RGlsbGVyLCBGLjwvYXV0aG9yPjxhdXRo

b3I+VmljdG9yLCBOLjwvYXV0aG9yPjxhdXRob3I+R29obGtlLCBILjwvYXV0aG9yPjxhdXRob3I+

R290dHdpaywgTS48L2F1dGhvcj48YXV0aG9yPlN0ZWluYmVjaywgRy48L2F1dGhvcj48YXV0aG9y

PkRlbCBDYXN0aWxsbywgVS48L2F1dGhvcj48YXV0aG9yPlNhY2ssIFIuPC9hdXRob3I+PGF1dGhv

cj5Xb3J0aCwgSC48L2F1dGhvcj48YXV0aG9yPkthdHVzLCBILjwvYXV0aG9yPjxhdXRob3I+U3Bp

dHplciwgVy48L2F1dGhvcj48YXV0aG9yPlNhYmluLCBHLjwvYXV0aG9yPjxhdXRob3I+U2VuZ2Vz

LCBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5PTUVH

QSwgYSByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgdHJpYWwgdG8gdGVzdCB0aGUgZWZm

ZWN0IG9mIGhpZ2hseSBwdXJpZmllZCBvbWVnYS0zIGZhdHR5IGFjaWRzIG9uIHRvcCBvZiBtb2Rl

cm4gZ3VpZGVsaW5lLWFkanVzdGVkIHRoZXJhcHkgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9u

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmN1bGF0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4yMTUyLTIxNTk8L3BhZ2VzPjx2b2x1bWU+MTIyPC92b2x1bWU+PG51

bWJlcj4yMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91

cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkh1bnRpbmd0b24gU3R1ZHk8L0F1dGhv

cj48WWVhcj4yMDA4PC9ZZWFyPjxSZWNOdW0+NzE0MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i

ZXI+NzE0MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUy

ejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjEzMzY4

Ij43MTQzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IdW50aW5ndG9u

IFN0dWR5IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0

aXRsZT5SYW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWwgb2YgZXRoeWwtZWljb3NhcGVudGFlbm9p

YyBhY2lkIGluIEh1bnRpbmd0b24gZGlzZWFzZTogdGhlIFRSRU5ELUhEIHN0dWR5PC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+QXJjaCBOZXVyb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BcmNoaXZlcyBvZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoIE5l

dXJvbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJj

aGl2ZXMgb2YgTmV1cm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+QXJjaCBOZXVyb2w8L2FiYnIt

MT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNTgyLTE1ODk8L3BhZ2VzPjx2b2x1bWU+NjU8L3Zv

bHVtZT48bnVtYmVyPjEyPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVw

cmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdCBBbmFseXNpcyBvZiBWYXJpYW5j

ZSBDYW5hZGEgRG91YmxlLUJsaW5kIE1ldGhvZCAqRWljb3NhcGVudGFlbm9pYyBBY2lkL2FhIFtB

bmFsb2dzICZhbXA7IERlcml2YXRpdmVzXSBFaWNvc2FwZW50YWVub2ljIEFjaWQvdHUgW1RoZXJh

cGV1dGljIFVzZV0gRmVtYWxlIEZvbGxvdy1VcCBTdHVkaWVzIEh1bWFucyAqSHVudGluZ3RvbiBE

aXNlYXNlL2R0IFtEcnVnIFRoZXJhcHldIEh1bnRpbmd0b24gRGlzZWFzZS9nZSBbR2VuZXRpY3Nd

ICpIdTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTUzOC0zNjg3PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAw

MS9hcmNobmV1ci42NS4xMi4xNTgyO0NsaW5pY2FsIFRyaWFsIE11bHRpY2VudGVyIFN0dWR5IFJh

bmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym

YXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Au

b3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1m

dWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xOTA2NDc0NWh0dHA6Ly9zZngudWNsLmFjLnVrL3Nm

eF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE5MDY0NzQ1JmFtcDtpZD1kb2k6

MTAuMTAwMSUyRmFyY2huZXVyLjY1LjEyLjE1ODImYW1wO2lzc249MDAwMy05OTQyJmFtcDtpc2Ju

PSZhbXA7dm9sdW1lPTY1JmFtcDtpc3N1ZT0xMiZhbXA7c3BhZ2U9MTU4MiZhbXA7cGFnZXM9MTU4

Mi05JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPUFyY2hpdmVzK29mK05ldXJvbG9neSZhbXA7YXRp

dGxlPVJhbmRvbWl6ZWQrY29udHJvbGxlZCt0cmlhbCtvZitldGh5bC1laWNvc2FwZW50YWVub2lj

K2FjaWQraW4rSHVudGluZ3RvbitkaXNlYXNlJTNBK3RoZStUUkVORC1IRCtzdHVkeS4mYW1wO2F1

bGFzdD1IdW50aW5ndG9uK1N0dWR5K0dyb3VwK1RSRU5ELUhEPC91cmw+PC9yZWxhdGVkLXVybHM+

PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (33, 40) including 2389 participants could not be included in meta-analysis as no variance was provided but suggested similar final scores in both arms using the Beck Depression Inventory (Figure 3). A further three trials that assessed relevant outcomes provided no data PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYW50aGlpcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xODMxNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNiwgMTUsIDI4KTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xODMxNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMzA0MDk3Ij4xODMxNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+RGFudGhpaXIsIFYuPC9hdXRob3I+PGF1dGhvcj5Ib3NraW5nLCBELjwvYXV0

aG9yPjxhdXRob3I+QnVybnMsIE4uIFIuPC9hdXRob3I+PGF1dGhvcj5XaWxzb24sIEMuPC9hdXRo

b3I+PGF1dGhvcj5OZXR0ZWxiZWNrLCBULjwvYXV0aG9yPjxhdXRob3I+Q2FsdmFyZXNpLCBFLjwv

YXV0aG9yPjxhdXRob3I+ZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

dGl0bGVzPjx0aXRsZT5Db2duaXRpdmUgcGVyZm9ybWFuY2UgaW4gb2xkZXIgYWR1bHRzIGlzIGlu

dmVyc2VseSBhc3NvY2lhdGVkIHdpdGggZmlzaCBjb25zdW1wdGlvbiBidXQgbm90IGVyeXRocm9j

eXRlIG1lbWJyYW5lIG4tMyBmYXR0eSBhY2lkczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaGUg

Sm91cm5hbCBvZiBudXRyaXRpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkog

TnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIGpvdXJuYWwgb2YgbnV0cml0aW9uPC9hYmJyLTI+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4zMTEtMzIwPC9wYWdlcz48dm9sdW1lPjE0NDwvdm9sdW1lPjxudW1i

ZXI+MzwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxz

PjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNoaXU8L0F1dGhvcj48WWVhcj4yMDA4PC9Z

ZWFyPjxSZWNOdW0+Mjg2MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Mjg2MjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVl

MGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjExMDAwIj4yODYyPC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGl1LCBDLiBDLjwvYXV0aG9yPjxhdXRo

b3I+U3UsIEsuIFAuPC9hdXRob3I+PGF1dGhvcj5DaGVuZywgVC4gQy48L2F1dGhvcj48YXV0aG9y

PkxpdSwgSC4gQy48L2F1dGhvcj48YXV0aG9yPkNoYW5nLCBDLiBKLjwvYXV0aG9yPjxhdXRob3I+

RGV3ZXksIE0uIEUuPC9hdXRob3I+PGF1dGhvcj5TdGV3YXJ0LCBSLjwvYXV0aG9yPjxhdXRob3I+

SHVhbmcsIFMuIFkuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+Q2hpdSxDaGloLUNoaWFuZy4gRGVwYXJ0bWVudCBvZiBQc3ljaGlhdHJ5LCBUYWlwZWkgQ2l0

eSBQc3ljaGlhdHJpYyBDZW50ZXIsIFRhaXBlaSBDaXR5IEhvc3BpdGFsLCBEZXBhcnRtZW50IG9m

IFBzeWNoaWF0cnksIFRhaXBlaSBNZWRpY2FsIFVuaXZlcnNpdHksIFRhaXBlaSwgVGFpd2FuPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVmZmVjdHMgb2Ygb21lZ2EtMyBmYXR0eSBh

Y2lkcyBtb25vdGhlcmFweSBpbiBBbHpoZWltZXImYXBvcztzIGRpc2Vhc2UgYW5kIG1pbGQgY29n

bml0aXZlIGltcGFpcm1lbnQ6IGEgcHJlbGltaW5hcnkgcmFuZG9taXplZCBkb3VibGUtYmxpbmQg

cGxhY2Viby1jb250cm9sbGVkIHN0dWR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlByb2dyZXNz

IGluIE5ldXJvLVBzeWNob3BoYXJtYWNvbG9neSAmYW1wOyBCaW9sb2dpY2FsIFBzeWNoaWF0cnk8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlByb2cgTmV1cm9wc3ljaG9waGFybWFjb2wgQmlv

bCBQc3ljaGlhdHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

UHJvZ3Jlc3MgaW4gTmV1cm8tUHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7IEJpb2xvZ2ljYWwgUHN5

Y2hpYXRyeTwvZnVsbC10aXRsZT48YWJici0xPlByb2cgTmV1cm9wc3ljaG9waGFybWFjb2wgQmlv

bCBQc3ljaGlhdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5Qcm9ncmVzcyBpbiBOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3kgJmFtcDsgQmlvbG9naWNh

bCBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNv

bCBCaW9sIFBzeWNoaWF0cnk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNTM4LTE1

NDQ8L3BhZ2VzPjx2b2x1bWU+MzI8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFn

ZWQgQWdlZCw4MCBhbmQgb3ZlciBBbHpoZWltZXIgRGlzZWFzZS9ibCBbQmxvb2RdICpBbHpoZWlt

ZXIgRGlzZWFzZS9kdCBbRHJ1ZyBUaGVyYXB5XSBBbHpoZWltZXIgRGlzZWFzZS9weCBbUHN5Y2hv

bG9neV0gQ29nbml0aW9uIERpc29yZGVycy9ibCBbQmxvb2RdICpDb2duaXRpb24gRGlzb3JkZXJz

L2R0IFtEcnVnIFRoZXJhcHldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHggW1BzeWNob2xvZ3ldIERv

dWJsZS1CbGluZCBNZXRob2QgRWljb3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAyNzgtNTg0NjwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5wbnBicC4yMDA4LjA1LjAxNTtSYW5kb21pemVkIENvbnRy

b2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10

eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3

ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9

bWVkNSZhbXA7QU49MTg1NzM1ODVodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9W

SUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoxODU3MzU4NSZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLnBu

cGJwLjIwMDguMDUuMDE1JmFtcDtpc3NuPTAyNzgtNTg0NiZhbXA7aXNibj0mYW1wO3ZvbHVtZT0z

MiZhbXA7aXNzdWU9NiZhbXA7c3BhZ2U9MTUzOCZhbXA7cGFnZXM9MTUzOC00NCZhbXA7ZGF0ZT0y

MDA4JmFtcDt0aXRsZT1Qcm9ncmVzcytpbitOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3krJTI2K0Jp

b2xvZ2ljYWwrUHN5Y2hpYXRyeSZhbXA7YXRpdGxlPVRoZStlZmZlY3RzK29mK29tZWdhLTMrZmF0

dHkrYWNpZHMrbW9ub3RoZXJhcHkraW4rQWx6aGVpbWVyJTI3cytkaXNlYXNlK2FuZCttaWxkK2Nv

Z25pdGl2ZStpbXBhaXJtZW50JTNBK2ErcHJlbGltaW5hcnkrcmFuZG9taXplZCtkb3VibGUtYmxp

bmQrcGxhY2Viby1jb250cm9sbGVkK3N0dWR5LiZhbXA7YXVsYXN0PUNoaXU8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+UGFsbWE8L0F1dGhv

cj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNOdW0+MTk5MDA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjE5OTAwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

NTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAzNTUz

NjkiPjE5OTAwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYWxtYSwg

Qy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+T21lZ2Eg

MyBmYXR0eSBhY2lkcyBzdXBwbGVtZW50YXRpb24gaW4gU2NoaXpvcGhyZW5pYTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5FdXJvcGVhbiBBcmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNh

bCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5FdXJvcGVhbiBBcmNoaXZlcyBvZiBQc3ljaGlhdHJ5ICZhbXA7IENsaW5pY2FsIE5l

dXJvc2NpZW5jZTwvZnVsbC10aXRsZT48YWJici0xPkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBO

ZXVyb3NjaTwvYWJici0xPjxhYmJyLTI+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRyeSBh

bmQgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz5TMTIy

LVMxMjI8L3BhZ2VzPjx2b2x1bWU+MjY1PC92b2x1bWU+PG51bWJlcj5TdXBwbGVtZW50IDE8L251

bWJlcj48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYW50aGlpcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xODMxNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNiwgMTUsIDI4KTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xODMxNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMzA0MDk3Ij4xODMxNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+RGFudGhpaXIsIFYuPC9hdXRob3I+PGF1dGhvcj5Ib3NraW5nLCBELjwvYXV0

aG9yPjxhdXRob3I+QnVybnMsIE4uIFIuPC9hdXRob3I+PGF1dGhvcj5XaWxzb24sIEMuPC9hdXRo

b3I+PGF1dGhvcj5OZXR0ZWxiZWNrLCBULjwvYXV0aG9yPjxhdXRob3I+Q2FsdmFyZXNpLCBFLjwv

YXV0aG9yPjxhdXRob3I+ZXQsIGEgbDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

dGl0bGVzPjx0aXRsZT5Db2duaXRpdmUgcGVyZm9ybWFuY2UgaW4gb2xkZXIgYWR1bHRzIGlzIGlu

dmVyc2VseSBhc3NvY2lhdGVkIHdpdGggZmlzaCBjb25zdW1wdGlvbiBidXQgbm90IGVyeXRocm9j

eXRlIG1lbWJyYW5lIG4tMyBmYXR0eSBhY2lkczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5UaGUg

Sm91cm5hbCBvZiBudXRyaXRpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkog

TnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIGpvdXJuYWwgb2YgbnV0cml0aW9uPC9hYmJyLTI+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4zMTEtMzIwPC9wYWdlcz48dm9sdW1lPjE0NDwvdm9sdW1lPjxudW1i

ZXI+MzwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxz

PjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNoaXU8L0F1dGhvcj48WWVhcj4yMDA4PC9Z

ZWFyPjxSZWNOdW0+Mjg2MjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Mjg2MjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVl

MGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMjExMDAwIj4yODYyPC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DaGl1LCBDLiBDLjwvYXV0aG9yPjxhdXRo

b3I+U3UsIEsuIFAuPC9hdXRob3I+PGF1dGhvcj5DaGVuZywgVC4gQy48L2F1dGhvcj48YXV0aG9y

PkxpdSwgSC4gQy48L2F1dGhvcj48YXV0aG9yPkNoYW5nLCBDLiBKLjwvYXV0aG9yPjxhdXRob3I+

RGV3ZXksIE0uIEUuPC9hdXRob3I+PGF1dGhvcj5TdGV3YXJ0LCBSLjwvYXV0aG9yPjxhdXRob3I+

SHVhbmcsIFMuIFkuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+Q2hpdSxDaGloLUNoaWFuZy4gRGVwYXJ0bWVudCBvZiBQc3ljaGlhdHJ5LCBUYWlwZWkgQ2l0

eSBQc3ljaGlhdHJpYyBDZW50ZXIsIFRhaXBlaSBDaXR5IEhvc3BpdGFsLCBEZXBhcnRtZW50IG9m

IFBzeWNoaWF0cnksIFRhaXBlaSBNZWRpY2FsIFVuaXZlcnNpdHksIFRhaXBlaSwgVGFpd2FuPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIGVmZmVjdHMgb2Ygb21lZ2EtMyBmYXR0eSBh

Y2lkcyBtb25vdGhlcmFweSBpbiBBbHpoZWltZXImYXBvcztzIGRpc2Vhc2UgYW5kIG1pbGQgY29n

bml0aXZlIGltcGFpcm1lbnQ6IGEgcHJlbGltaW5hcnkgcmFuZG9taXplZCBkb3VibGUtYmxpbmQg

cGxhY2Viby1jb250cm9sbGVkIHN0dWR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlByb2dyZXNz

IGluIE5ldXJvLVBzeWNob3BoYXJtYWNvbG9neSAmYW1wOyBCaW9sb2dpY2FsIFBzeWNoaWF0cnk8

L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlByb2cgTmV1cm9wc3ljaG9waGFybWFjb2wgQmlv

bCBQc3ljaGlhdHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

UHJvZ3Jlc3MgaW4gTmV1cm8tUHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7IEJpb2xvZ2ljYWwgUHN5

Y2hpYXRyeTwvZnVsbC10aXRsZT48YWJici0xPlByb2cgTmV1cm9wc3ljaG9waGFybWFjb2wgQmlv

bCBQc3ljaGlhdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10

aXRsZT5Qcm9ncmVzcyBpbiBOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3kgJmFtcDsgQmlvbG9naWNh

bCBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBOZXVyb3BzeWNob3BoYXJtYWNv

bCBCaW9sIFBzeWNoaWF0cnk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNTM4LTE1

NDQ8L3BhZ2VzPjx2b2x1bWU+MzI8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFn

ZWQgQWdlZCw4MCBhbmQgb3ZlciBBbHpoZWltZXIgRGlzZWFzZS9ibCBbQmxvb2RdICpBbHpoZWlt

ZXIgRGlzZWFzZS9kdCBbRHJ1ZyBUaGVyYXB5XSBBbHpoZWltZXIgRGlzZWFzZS9weCBbUHN5Y2hv

bG9neV0gQ29nbml0aW9uIERpc29yZGVycy9ibCBbQmxvb2RdICpDb2duaXRpb24gRGlzb3JkZXJz

L2R0IFtEcnVnIFRoZXJhcHldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHggW1BzeWNob2xvZ3ldIERv

dWJsZS1CbGluZCBNZXRob2QgRWljb3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAyNzgtNTg0NjwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5wbnBicC4yMDA4LjA1LjAxNTtSYW5kb21pemVkIENvbnRy

b2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10

eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3

ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9

bWVkNSZhbXA7QU49MTg1NzM1ODVodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9W

SUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoxODU3MzU4NSZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLnBu

cGJwLjIwMDguMDUuMDE1JmFtcDtpc3NuPTAyNzgtNTg0NiZhbXA7aXNibj0mYW1wO3ZvbHVtZT0z

MiZhbXA7aXNzdWU9NiZhbXA7c3BhZ2U9MTUzOCZhbXA7cGFnZXM9MTUzOC00NCZhbXA7ZGF0ZT0y

MDA4JmFtcDt0aXRsZT1Qcm9ncmVzcytpbitOZXVyby1Qc3ljaG9waGFybWFjb2xvZ3krJTI2K0Jp

b2xvZ2ljYWwrUHN5Y2hpYXRyeSZhbXA7YXRpdGxlPVRoZStlZmZlY3RzK29mK29tZWdhLTMrZmF0

dHkrYWNpZHMrbW9ub3RoZXJhcHkraW4rQWx6aGVpbWVyJTI3cytkaXNlYXNlK2FuZCttaWxkK2Nv

Z25pdGl2ZStpbXBhaXJtZW50JTNBK2ErcHJlbGltaW5hcnkrcmFuZG9taXplZCtkb3VibGUtYmxp

bmQrcGxhY2Viby1jb250cm9sbGVkK3N0dWR5LiZhbXA7YXVsYXN0PUNoaXU8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+UGFsbWE8L0F1dGhv

cj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNOdW0+MTk5MDA8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjE5OTAwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

NTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzAzNTUz

NjkiPjE5OTAwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5QYWxtYSwg

Qy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+T21lZ2Eg

MyBmYXR0eSBhY2lkcyBzdXBwbGVtZW50YXRpb24gaW4gU2NoaXpvcGhyZW5pYTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5FdXJvcGVhbiBBcmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNh

bCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5FdXJvcGVhbiBBcmNoaXZlcyBvZiBQc3ljaGlhdHJ5ICZhbXA7IENsaW5pY2FsIE5l

dXJvc2NpZW5jZTwvZnVsbC10aXRsZT48YWJici0xPkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBO

ZXVyb3NjaTwvYWJici0xPjxhYmJyLTI+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRyeSBh

bmQgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz5TMTIy

LVMxMjI8L3BhZ2VzPjx2b2x1bWU+MjY1PC92b2x1bWU+PG51bWJlcj5TdXBwbGVtZW50IDE8L251

bWJlcj48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (6, 15, 28), and the funnel plot suggests trials showing worsening of depression severity with increased LCn3 may be missing (Supplementary Figure 9). This suggestion of small study bias was confirmed by Egger’s test for small study effects (p=0.029). If such studies were added into the analysis the SMD would tend to increase, suggesting some worsening of depression from increasing LCn3. However, the similarity of the random- and fixed-effects meta-analyses, which weight small studies differently (random effects: SMD 0.01, 95% CI -0.06 to 0.07; fixed-effects: SMD 0.02, 95% CI -0.02 to 0.06) suggest that the small study bias is not a very large problem. ADDIN EN.CITE <EndNote><Cite><Author>Page</Author><Year>2019</Year><RecNum>22162</RecNum><DisplayText>(39)</DisplayText><record><rec-number>22162</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1565082516">22162</key></foreign-keys><ref-type name="Book Section">5</ref-type><contributors><authors><author>Page, M.J.</author><author>Higgins, J. P. T.</author><author>Sterne, J. A. C.</author></authors><secondary-authors><author>HIggins, J.P.T.</author><author>Thomas, J.</author><author>Chandler, J.</author><author>Cumpston, M.</author><author>Li, T.</author><author>Page, M. J.</author><author>Welch, V. A. </author></secondary-authors></contributors><titles><title>Chapter 13: Assessing risk of bias due to missing results in a synthesis. Draft version (29 Janaury 2019) for inclusion in</title><secondary-title>Cochrane Handbook for Systematic Reviews of Interventions</secondary-title></titles><dates><year>2019</year></dates><pub-location>London</pub-location><publisher>Cochrane</publisher><urls></urls></record></Cite></EndNote>(39) Overall we believe that the effect of small study bias is small. GRADE assessment suggests that increasing LCn3 probably has little or no effect on depression symptoms (moderate-quality evidence, downgraded once for publication bias, Supplementary Table 3).A single large trial assessed effects of increasing ALA by 2g/d over 40 months on depression symptoms found little or no effect on the GDS (MD -0.02, 95% CI -0.14 to 0.10, 4068 participants, unaltered in sensitivity analyses, Supplementary Table 4). We found no data on effects of omega-6 or total PUFA on depression symptoms. GRADE assessment suggests that increasing ALA may have little or no effect on the severity of depression (low-quality evidence, downgraded once each for imprecision and risk of bias, Supplementary Table 7).Anxiety incidence and remission. One study at low summary risk of bias provided data on effects of 0.84g/d LCn3 on risk of anxiety symptoms over 74 months, with only 12 evenly distributed cases in 15480 participants (RR 1.00, 95% CI 0.32 to 3.10) ADDIN EN.CITE <EndNote><Cite><Author>ASCEND Study Collaborative Group</Author><Year>2018</Year><RecNum>21701</RecNum><DisplayText>(4)</DisplayText><record><rec-number>21701</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1542140629">21701</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>ASCEND Study Collaborative Group,</author></authors></contributors><titles><title>Effects of n?3 Fatty Acid Supplements in Diabetes Mellitus</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N Engl J Med</abbr-1><abbr-2>NEJM</abbr-2><abbr-3>The New England Journal of Medicine</abbr-3></periodical><pages>1540-1550</pages><volume>379</volume><number>16</number><dates><year>2018</year><pub-dates><date>2018/10/18</date></pub-dates></dates><publisher>Massachusetts Medical Society</publisher><isbn>0028-4793</isbn><urls><related-urls><url>;(4), none on remission. No studies provided data on effects of ALA, omega-6 or total PUFA on anxiety incidence or remission. Anxiety symptoms assessed on continuous scales (in those not selected for anxiety at baseline)Five studies assessed effects of increasing LCn3 on anxiety symptoms using four different scales (SMD 0.15, 95% CI 0.05 to 0.26, I2 0%, 1378 participants, mean does 1.4g/d, SD 0.7, median dose 1.1g/d, range 0.5 to 2.4g/d LCn3, mean trial duration 26 months, SD 30, median 6 months, range 6 to 35 months, Supplementary Figure 10). No included studies were at low summary risk of bias, but other sensitivity analyses reflected the main analysis. Subgrouping and funnel plots were not attempted as there were too few trials, we are not aware of missing data. No trials of ALA, omega-6 or total PUFA reported on anxiety symptoms. GRADE assessment suggests that increasing LCn3 probably has little or no effect on anxiety symptoms (moderate-quality evidence, downgraded once for risk of bias, Supplementary Table 3).Effects of LCn3 vs omega-6We assessed effects of LCn3 vs omega-6 to help understand whether omega-3 is helpful, while omega-6 is harmful. If this were the case we would expect to see a greater effect of LCn3 when it replaces omega-6. There was no indication that effects of replacing omega-6 with LCn3 differed from replacement of any other dietary component for depression incidence or severity (Supplementary Table 2). Secondary outcomesWe found no outcome data on effects of increasing LCn3 on social participation, psychosis, self-harm, costs or fidelity of the intervention. Data on quality of life, carer stress, suicidality, adverse events, drop outs and drop outs due to adverse events are reported in Supplementary Table 8. Data are sparse, often poorly reported and may suffer from reporting bias (we are aware of missing quality of life data for one trial PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYW4gRGUgUmVzdDwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT4xNjQ1MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDEpPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjE2NDUyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1l

c3RhbXA9IjE1MzAyMTg2NDIiPjE2NDUyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h

bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+

PGF1dGhvcj5WYW4gRGUgUmVzdCwgTy48L2F1dGhvcj48YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48

L2F1dGhvcj48YXV0aG9yPktvaywgRi4gSi48L2F1dGhvcj48YXV0aG9yPnZhbiBTdGF2ZXJlbiwg

Vy4gQS48L2F1dGhvcj48YXV0aG9yPkhvZWZuYWdlbHMsIFcuIEguPC9hdXRob3I+PGF1dGhvcj5C

ZWVrbWFuLCBBLiBULjwvYXV0aG9yPjxhdXRob3I+ZGUgR3Jvb3QsIEwuIEMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+dmFuIGRlIFJlc3QsT25kaW5lLiBX

YWdlbmluZ2VuIFVuaXZlcnNpdHksIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5p

bmdlbiwgTmV0aGVybGFuZHMuIG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGZpc2gtb2lsIHN1cHBsZW1lbnRhdGlvbiBvbiBtZW50

YWwgd2VsbC1iZWluZyBpbiBvbGRlciBzdWJqZWN0czogYSByYW5kb21pemVkLCBkb3VibGUtYmxp

bmQsIHBsYWNlYm8tY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVy

aWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQt

dGl0bGU+QW0gSiBDbGluIE51dHI8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvZnVsbC10aXRs

ZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSm91

cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9u

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0gSiBDbGluIE51dHI8L2FiYnItMT48YWJici0yPlRoZSBB

bWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvYWJici0yPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjcwNi03MTM8L3BhZ2VzPjx2b2x1bWU+ODg8L3ZvbHVtZT48bnVtYmVyPjM8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFnZWQgQW54aWV0eSBEZXByZXNzaW9uIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2Vd

IERvY29zYWhleGFlbm9pYyBBY2lkcy9ibCBbQmxvb2RdIERvY29zYWhleGFlbm9pYyBBY2lkcy9w

ZCBbUGhhcm1hY29sb2d5XSBEb3VibGUtQmxpbmQgTWV0aG9kIEVpY29zYXBlbnRhZW5vaWMgQWNp

ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBFaWNvc2FwZW50YWVubzwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzOC0z

MjA3PC9pc2JuPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNo

IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9

WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4Nzc5Mjg3

aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBt

aWQ6MTg3NzkyODcmYW1wO2lkPWRvaTomYW1wO2lzc249MDAwMi05MTY1JmFtcDtpc2JuPSZhbXA7

dm9sdW1lPTg4JmFtcDtpc3N1ZT0zJmFtcDtzcGFnZT03MDYmYW1wO3BhZ2VzPTcwNi0xMyZhbXA7

ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29mK0NsaW5pY2FsK051dHJpdGlv

biZhbXA7YXRpdGxlPUVmZmVjdCtvZitmaXNoLW9pbCtzdXBwbGVtZW50YXRpb24rb24rbWVudGFs

K3dlbGwtYmVpbmcraW4rb2xkZXIrc3ViamVjdHMlM0ErYStyYW5kb21pemVkJTJDK2RvdWJsZS1i

bGluZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFuK2RlK1Jlc3Q8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYW4gRGUgUmVzdDwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT4xNjQ1MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDEpPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjE2NDUyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1l

c3RhbXA9IjE1MzAyMTg2NDIiPjE2NDUyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h

bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+

PGF1dGhvcj5WYW4gRGUgUmVzdCwgTy48L2F1dGhvcj48YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48

L2F1dGhvcj48YXV0aG9yPktvaywgRi4gSi48L2F1dGhvcj48YXV0aG9yPnZhbiBTdGF2ZXJlbiwg

Vy4gQS48L2F1dGhvcj48YXV0aG9yPkhvZWZuYWdlbHMsIFcuIEguPC9hdXRob3I+PGF1dGhvcj5C

ZWVrbWFuLCBBLiBULjwvYXV0aG9yPjxhdXRob3I+ZGUgR3Jvb3QsIEwuIEMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+dmFuIGRlIFJlc3QsT25kaW5lLiBX

YWdlbmluZ2VuIFVuaXZlcnNpdHksIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5p

bmdlbiwgTmV0aGVybGFuZHMuIG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGZpc2gtb2lsIHN1cHBsZW1lbnRhdGlvbiBvbiBtZW50

YWwgd2VsbC1iZWluZyBpbiBvbGRlciBzdWJqZWN0czogYSByYW5kb21pemVkLCBkb3VibGUtYmxp

bmQsIHBsYWNlYm8tY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVy

aWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQt

dGl0bGU+QW0gSiBDbGluIE51dHI8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvZnVsbC10aXRs

ZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSm91

cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9u

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0gSiBDbGluIE51dHI8L2FiYnItMT48YWJici0yPlRoZSBB

bWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvYWJici0yPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjcwNi03MTM8L3BhZ2VzPjx2b2x1bWU+ODg8L3ZvbHVtZT48bnVtYmVyPjM8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFnZWQgQW54aWV0eSBEZXByZXNzaW9uIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2Vd

IERvY29zYWhleGFlbm9pYyBBY2lkcy9ibCBbQmxvb2RdIERvY29zYWhleGFlbm9pYyBBY2lkcy9w

ZCBbUGhhcm1hY29sb2d5XSBEb3VibGUtQmxpbmQgTWV0aG9kIEVpY29zYXBlbnRhZW5vaWMgQWNp

ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBFaWNvc2FwZW50YWVubzwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzOC0z

MjA3PC9pc2JuPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNo

IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9

WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4Nzc5Mjg3

aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBt

aWQ6MTg3NzkyODcmYW1wO2lkPWRvaTomYW1wO2lzc249MDAwMi05MTY1JmFtcDtpc2JuPSZhbXA7

dm9sdW1lPTg4JmFtcDtpc3N1ZT0zJmFtcDtzcGFnZT03MDYmYW1wO3BhZ2VzPTcwNi0xMyZhbXA7

ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29mK0NsaW5pY2FsK051dHJpdGlv

biZhbXA7YXRpdGxlPUVmZmVjdCtvZitmaXNoLW9pbCtzdXBwbGVtZW50YXRpb24rb24rbWVudGFs

K3dlbGwtYmVpbmcraW4rb2xkZXIrc3ViamVjdHMlM0ErYStyYW5kb21pemVkJTJDK2RvdWJsZS1i

bGluZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFuK2RlK1Jlc3Q8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (41)). Drawing conclusions simply on statistical significance of the SMD analyses, one trial suggested improvements in the Life Satisfaction Index with higher LCn3, but another did not suggest changes in SF-36 mental or physical components. Caregiver burden was assessed in two trials, suggesting a reduction in caregiver burden in one small trial, but no change in emotional or economic burden in another. There were no important differences in acceptability of LCn3 or its control when assessed through dropouts, and no effect of increasing LCn3 on dropouts due to adverse effects. Adverse events reported by at least 4 trials suggested no effect on gastrointestinal side effects, respiratory or nervous systems, an increased risk of urogenital problems and bleeding, and reduced risk of skin problems with increased LCn3 but these are based on few reports. We have formally systematically reviewed effects of omega-3, omega-6 and total PUFA on cancer, diabetes, cognition, inflammatory bowel disease, cardiovascular disease, functional outcomes, mortality, adiposity and lipids in sister reviews. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmRlbGhhbWlkPC9BdXRob3I+PFllYXI+MjAxODwvWWVh

cj48UmVjTnVtPjIxNjM4PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxLCA0Mi00OSk8L0Rpc3BsYXlU

ZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjE2Mzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzNDE3NjU1MSI+MjE2Mzg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPkFiZGVsaGFtaWQsIEFzbWFhIFMuPC9hdXRob3I+PGF1dGhvcj5Ccm93biwg

VHJhY2V5IEouPC9hdXRob3I+PGF1dGhvcj5CcmFpbmFyZCwgSnVsaWkgUy48L2F1dGhvcj48YXV0

aG9yPkJpc3dhcywgUHJpdGk8L2F1dGhvcj48YXV0aG9yPlRob3JwZSwgR2FicmllbGxlIEMuPC9h

dXRob3I+PGF1dGhvcj5Nb29yZSwgSGVsZW4gSi48L2F1dGhvcj48YXV0aG9yPkRlYW5lLCBLYXRo

ZXJpbmUgSG88L2F1dGhvcj48YXV0aG9yPkFsQWJkdWxnaGFmb29yLCBGYWkgSy48L2F1dGhvcj48

YXV0aG9yPlN1bW1lcmJlbGwsIENhcm9seW4gRC48L2F1dGhvcj48YXV0aG9yPldvcnRoaW5ndG9u

LCBIZWxlbiBWLjwvYXV0aG9yPjxhdXRob3I+U29uZywgRnVqaWFuPC9hdXRob3I+PGF1dGhvcj5I

b29wZXIsIExlZTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT5PbWVnYS0zIGZhdHR5IGFjaWRzIGZvciB0aGUgcHJpbWFyeSBhbmQgc2Vjb25kYXJ5IHByZXZl

bnRpb24gb2YgY2FyZGlvdmFzY3VsYXIgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5D

b2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0ZW1hdGljIFJldmlld3M8L3NlY29uZGFyeS10aXRsZT48

dGVydGlhcnktdGl0bGU+W1VwZGF0ZSBvZiBDb2NocmFuZSBEYXRhYmFzZSBTeXN0IFJldi4gMjAw

NCBPY3QgMTg7KDQpOkNEMDAzMTc3OyBQTUlEOiAxNTQ5NTA0NF08L3RlcnRpYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNvY2hyYW5lIERhdGFiYXNlIG9mIFN5c3Rl

bWF0aWMgUmV2aWV3czwvZnVsbC10aXRsZT48YWJici0xPkNvY2hyYW5lIERhdGFiYXNlIFN5c3Qg

UmV2PC9hYmJyLTE+PGFiYnItMj5UaGUgQ29jaHJhbmUgZGF0YWJhc2Ugb2Ygc3lzdGVtYXRpYyBy

ZXZpZXdzPC9hYmJyLTI+PGFiYnItMz5Db2NocmFuZSBkYXRhYmFzZSBvZiBzeXN0ZW1hdGljIHJl

dmlld3MgKG9ubGluZSk8L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPkNEMDAzMTc3PC9wYWdl

cz48dm9sdW1lPjExPC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PC9kYXRlcz48cHVi

LWxvY2F0aW9uPkVuZ2xhbmQ8L3B1Yi1sb2NhdGlvbj48aXNibj4xNDY5LTQ5M1gmI3hEOzEzNjEt

NjEzNzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNv

bS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtQQUdFPXJlZmVyZW5jZSZhbXA7RD1wcmVtJmFtcDtORVdT

PU4mYW1wO0FOPTMwMDE5NzY2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT5ET0k6IDEwLjEwMDIvMTQ2NTE4NTguQ0QwMDMxNzcucHViNDwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QWJkZWxoYW1p

ZDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT4yMTYzNzwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjE2Mzc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzNDE3NjU0NiI+MjE2Mzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkFiZGVsaGFtaWQsIEFzbWFhIFMuPC9hdXRob3I+PGF1dGhvcj5NYXJ0aW4sIE5pY29sZTwvYXV0

aG9yPjxhdXRob3I+QnJpZGdlcywgQ2hhcmxlbmU8L2F1dGhvcj48YXV0aG9yPkJyYWluYXJkLCBK

dWxpaSBTLjwvYXV0aG9yPjxhdXRob3I+V2FuZywgWGlhPC9hdXRob3I+PGF1dGhvcj5Ccm93biwg

VHJhY2V5IEouPC9hdXRob3I+PGF1dGhvcj5IYW5zb24sIFNhcmFoPC9hdXRob3I+PGF1dGhvcj5K

aW1vaCwgT2x1c2V5aSBGLjwvYXV0aG9yPjxhdXRob3I+QWphYm5vb3IsIFNhcmFoIE0uPC9hdXRo

b3I+PGF1dGhvcj5EZWFuZSwgS2F0aGVyaW5lIEhvPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBGdWpp

YW48L2F1dGhvcj48YXV0aG9yPkhvb3BlciwgTGVlPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjx0aXRsZXM+PHRpdGxlPlBvbHl1bnNhdHVyYXRlZCBmYXR0eSBhY2lkcyBmb3IgdGhl

IHByaW1hcnkgYW5kIHNlY29uZGFyeSBwcmV2ZW50aW9uIG9mIGNhcmRpb3Zhc2N1bGFyIGRpc2Vh

c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q29jaHJhbmUgRGF0YWJhc2Ugb2YgU3lzdGVtYXRp

YyBSZXZpZXdzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+Q29jaHJhbmUgRGF0YWJhc2Ugb2YgU3lzdGVtYXRpYyBSZXZpZXdzPC9mdWxsLXRpdGxlPjxh

YmJyLTE+Q29jaHJhbmUgRGF0YWJhc2UgU3lzdCBSZXY8L2FiYnItMT48YWJici0yPlRoZSBDb2No

cmFuZSBkYXRhYmFzZSBvZiBzeXN0ZW1hdGljIHJldmlld3M8L2FiYnItMj48YWJici0zPkNvY2hy

YW5lIGRhdGFiYXNlIG9mIHN5c3RlbWF0aWMgcmV2aWV3cyAob25saW5lKTwvYWJici0zPjwvcGVy

aW9kaWNhbD48cGFnZXM+Q0QwMTIzNDU8L3BhZ2VzPjx2b2x1bWU+MTE8L3ZvbHVtZT48ZGF0ZXM+

PHllYXI+MjAxODwveWVhcj48L2RhdGVzPjxwdWItbG9jYXRpb24+RW5nbGFuZDwvcHViLWxvY2F0

aW9uPjxpc2JuPjE0NjktNDkzWCYjeEQ7MTM2MS02MTM3PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO1BBR0U9

cmVmZXJlbmNlJmFtcDtEPXByZW0mYW1wO05FV1M9TiZhbXA7QU49MzAwMTk3Njc8L3VybD48L3Jl

bGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPkRPSTogMTAuMTAwMi8x

NDY1MTg1OC5DRDAxMjM0NS5wdWIzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5Ib29wZXI8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO

dW0+MjE2Mzk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIxNjM5PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0

YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzQxNzY1NTIiPjIxNjM5PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ib29wZXIsIExlZTwvYXV0aG9yPjxhdXRob3I+QWwt

S2h1ZGFpcnksIExlbmE8L2F1dGhvcj48YXV0aG9yPkFiZGVsaGFtaWQsIEFzbWFhIFMuPC9hdXRo

b3I+PGF1dGhvcj5SZWVzLCBLYXJlbjwvYXV0aG9yPjxhdXRob3I+QnJhaW5hcmQsIEp1bGlpIFMu

PC9hdXRob3I+PGF1dGhvcj5Ccm93biwgVHJhY2V5IEouPC9hdXRob3I+PGF1dGhvcj5BamFibm9v

ciwgU2FyYWggTS48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztCcmllbiwgQWxleCBULjwvYXV0aG9y

PjxhdXRob3I+V2luc3RhbmxleSwgTGF1cmVuIEUuPC9hdXRob3I+PGF1dGhvcj5Eb25hbGRzb24s

IERhaXN5IEguPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBGdWppYW48L2F1dGhvcj48YXV0aG9yPkRl

YW5lLCBLYXRoZXJpbmUgSG88L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxl

cz48dGl0bGU+T21lZ2EtNiBmYXRzIGZvciB0aGUgcHJpbWFyeSBhbmQgc2Vjb25kYXJ5IHByZXZl

bnRpb24gb2YgY2FyZGlvdmFzY3VsYXIgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5D

b2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0ZW1hdGljIFJldmlld3M8L3NlY29uZGFyeS10aXRsZT48

dGVydGlhcnktdGl0bGU+W1VwZGF0ZSBvZiBDb2NocmFuZSBEYXRhYmFzZSBTeXN0IFJldi4gMjAx

NSBOb3YgMTY7KDExKTpDRDAxMTA5NDsgUE1JRDogMjY1NzE0NTFdPC90ZXJ0aWFyeS10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Db2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0

ZW1hdGljIFJldmlld3M8L2Z1bGwtdGl0bGU+PGFiYnItMT5Db2NocmFuZSBEYXRhYmFzZSBTeXN0

IFJldjwvYWJici0xPjxhYmJyLTI+VGhlIENvY2hyYW5lIGRhdGFiYXNlIG9mIHN5c3RlbWF0aWMg

cmV2aWV3czwvYWJici0yPjxhYmJyLTM+Q29jaHJhbmUgZGF0YWJhc2Ugb2Ygc3lzdGVtYXRpYyBy

ZXZpZXdzIChvbmxpbmUpPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz5DRDAxMTA5NDwvcGFn

ZXM+PHZvbHVtZT4xMTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDE4PC95ZWFyPjwvZGF0ZXM+PHB1

Yi1sb2NhdGlvbj5FbmdsYW5kPC9wdWItbG9jYXRpb24+PGlzYm4+MTQ2OS00OTNYJiN4RDsxMzYx

LTYxMzc8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7UEFHRT1yZWZlcmVuY2UmYW1wO0Q9cHJlbSZhbXA7TkVX

Uz1OJmFtcDtBTj0zMDAxOTc2NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+RE9JOiAxMC4xMDAyLzE0NjUxODU4LkNEMDExMDk0LnB1YjQ8L2VsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFiZGVsaGFt

aWQ8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+MjIxNDU8L1JlY051bT48cmVjb3Jk

PjxyZWMtbnVtYmVyPjIyMTQ1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1NjQzMzA0MjgiPjIyMTQ1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5BYmRlbGhhbWlkLCBBc21hYTwvYXV0aG9yPjxhdXRob3I+SG9vcGVyLCBMZWU8L2F1dGhvcj48

YXV0aG9yPlNpdmFrYXJhbiwgUnVrc2FuYTwvYXV0aG9yPjxhdXRob3I+SGF5aG9lLCBSaWNoYXJk

IFAuIEcuPC9hdXRob3I+PGF1dGhvcj5XZWxjaCwgQWlsc2E8L2F1dGhvcj48YXV0aG9yPlRoZSBQ

VUZBSCBHcm91cCw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0

bGU+VGhlIFJlbGF0aW9uc2hpcCBCZXR3ZWVuIE9tZWdhLTMsIE9tZWdhLTYgYW5kIFRvdGFsIFBv

bHl1bnNhdHVyYXRlZCBGYXQgYW5kIE11c2N1bG9za2VsZXRhbCBIZWFsdGggYW5kIEZ1bmN0aW9u

YWwgU3RhdHVzIGluIEFkdWx0czogQSBTeXN0ZW1hdGljIFJldmlldyBhbmQgTWV0YS1hbmFseXNp

cyBvZiBSQ1RzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNhbGNpZmllZCBUaXNzdWUgSW50ZXJu

YXRpb25hbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkNhbGNpZmllZCBUaXNzdWUgSW50ZXJuYXRpb25hbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+

PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDE5LzA3LzI1PC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzMi0wODI3PC9pc2JuPjx1cmxzPjxyZWxhdGVk

LXVybHM+PHVybD5odHRwczovL2RvaS5vcmcvMTAuMTAwNy9zMDAyMjMtMDE5LTAwNTg0LTM8L3Vy

bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPkRPSTogMTAu

MTAwNy9zMDAyMjMtMDE5LTAwNTg0LTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJyYWluYXJkPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjIyMDMwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMjAzMDwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2

ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTUzOTQ0MDI3Ij4yMjAzMDwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnJhaW5hcmQsIEouPC9hdXRob3I+PGF1dGhv

cj5KaW1vaCwgTy5GLjwvYXV0aG9yPjxhdXRob3I+RGVhbmUsIEsuPC9hdXRob3I+PGF1dGhvcj5C

aXN3YXMsIFAuPC9hdXRob3I+PGF1dGhvcj5Eb25hbGRzb24sIEQuPC9hdXRob3I+PGF1dGhvcj5N

YWFzLCBLLjwvYXV0aG9yPjxhdXRob3I+QWJkZWxoYW1pZCwgQS48L2F1dGhvcj48YXV0aG9yPkhv

b3BlciwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

T21lZ2EtMywgb21lZ2EtNiBhbmQgdG90YWwgcG9seXVuc2F0dXJhdGVkIGZhdCBmb3IgY29nbml0

aW9uIGFuZCBkZW1lbnRpYTogU3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMgb2Yg

UkNUczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5zdWJtaXR0ZWQ8L3NlY29uZGFyeS10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5zdWJtaXR0ZWQ8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJyb3duPC9BdXRob3I+PFllYXI+MjAxOTwvWWVh

cj48UmVjTnVtPjIyMTkyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMjE5MjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVl

MGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTY4MDMzMDkxIj4yMjE5Mjwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnJvd24sIFRyYWNleSBKPC9hdXRob3I+

PGF1dGhvcj5CcmFpbmFyZCwgSnVsaWk8L2F1dGhvcj48YXV0aG9yPlNvbmcsIEZ1amlhbjwvYXV0

aG9yPjxhdXRob3I+V2FuZywgWGlhPC9hdXRob3I+PGF1dGhvcj5BYmRlbGhhbWlkLCBBc21hYTwv

YXV0aG9yPjxhdXRob3I+SG9vcGVyLCBMZWU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PHRpdGxlcz48dGl0bGU+T21lZ2EtMywgb21lZ2EtNiwgYW5kIHRvdGFsIGRpZXRhcnkgcG9s

eXVuc2F0dXJhdGVkIGZhdCBmb3IgcHJldmVudGlvbiBhbmQgdHJlYXRtZW50IG9mIHR5cGUgMiBk

aWFiZXRlcyBtZWxsaXR1czogc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMgb2Yg

cmFuZG9taXNlZCBjb250cm9sbGVkIHRyaWFsczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CTUo8

L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Ccml0aXNo

IE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkJyIE1lZCBKPC9hYmJyLTE+PGFi

YnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+

bDQ2OTc8L3BhZ2VzPjx2b2x1bWU+MzY2PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+

PC9kYXRlcz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cuYm1qLmNvbS9jb250

ZW50L2Jtai8zNjYvYm1qLmw0Njk3LmZ1bGwucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5ET0k6IDEwLjExMzYvYm1qLmw0Njk3PC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYW5zb248L0F1

dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+MjIxMzg8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjIyMTM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NjI2

MTE2ODciPjIyMTM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYW5z

b24sIFMuPC9hdXRob3I+PGF1dGhvcj5UaG9ycGUsIEcuPC9hdXRob3I+PGF1dGhvcj5XaW5zdGFu

bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+QWJkZWxoYW1pZCwgQS5TLjwvYXV0aG9yPjxhdXRob3I+

SG9vcGVyLCBMLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT5PbWVnYS0zLCBvbWVnYS02IGFuZCB0b3RhbCBkaWV0YXJ5IHBvbHl1bnNhdHVyYXRlZCBmYXQg

b24gY2FuY2VyIGluY2lkZW5jZTogc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMg

b2YgcmFuZG9taXNlZCB0cmlhbHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+c3VibWl0dGVkPC9z

ZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+c3VibWl0dGVk

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48L2RhdGVz

Pjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Ib29wZXI8L0F1dGhv

cj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+MjE2OTc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjIxNjk3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

NTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NDEyNDE4

ODQiPjIxNjk3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ib29wZXIs

IExlZTwvYXV0aG9yPjxhdXRob3I+QWJkZWxoYW1pZCwgQXNtYWE8L2F1dGhvcj48YXV0aG9yPkJy

YWluYXJkLCBKdWxpaTwvYXV0aG9yPjxhdXRob3I+RGVhbmUsIEthdGhlcmluZSBILiBPLjwvYXV0

aG9yPjxhdXRob3I+U29uZywgRnVqaWFuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

Pjx0aXRsZXM+PHRpdGxlPkNyZWF0aW9uIG9mIGEgZGF0YWJhc2UgdG8gYXNzZXNzIGVmZmVjdHMg

b2Ygb21lZ2EtMywgb21lZ2EtNiBhbmQgdG90YWwgcG9seXVuc2F0dXJhdGVkIGZhdHMgb24gaGVh

bHRoOiBkYXRhYmFzZSBhbmQgbWV0aG9kb2xvZ3kgZm9yIGEgc2V0IG9mIHJldmlld3M8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+Qk1KIE9wZW4gPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1KIE9wZW48L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUogT3Bl

bjwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTAyOTU1NDwvcGFnZXM+PHZvbHVtZT45PC92

b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PC9kYXRlcz48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2Jtam9wZW4uYm1qLmNvbS9jb250ZW50Lzkv

NS9lMDI5NTU0LmFic3RyYWN0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT5ET0k6IDEwLjExMzYvYm1qb3Blbi0yMDE5LTAyOTU1NDwvZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+VGhvcnBlPC9BdXRo

b3I+PFllYXI+MjAxNzwvWWVhcj48UmVjTnVtPjE4ODU4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4xODg1ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMzUz

NTU2Ij4xODg1ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGhvcnBl

LCBHLjwvYXV0aG9yPjxhdXRob3I+QWphYm5vb3IsIFMuPC9hdXRob3I+PGF1dGhvcj5BaG1lZCwg

Wi48L2F1dGhvcj48YXV0aG9yPkFiZGVsaGFtaWQsIEEuPC9hdXRob3I+PGF1dGhvcj5Ib29wZXIs

IEwuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkRpZXRh

cnkgcG9seXVuc2F0dXJhdGVkIGZhdCBmb3IgcHJldmVudGlvbiBhbmQgdHJlYXRtZW50IG9mIGlu

ZmxhbW1hdG9yeSBib3dlbCBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBST1NQRVJP

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UFJPU1BF

Uk88L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz5DUkQ0MjAxNzA2ODcwNDwvcGFnZXM+

PGRhdGVzPjx5ZWFyPjIwMTc8L3llYXI+PC9kYXRlcz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

d3d3LmNyZC55b3JrLmFjLnVrL3Byb3NwZXJvL2Rpc3BsYXlfcmVjb3JkLnBocD9SZWNvcmRJRD02

ODcwNDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

PgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmRlbGhhbWlkPC9BdXRob3I+PFllYXI+MjAxODwvWWVh

cj48UmVjTnVtPjIxNjM4PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxLCA0Mi00OSk8L0Rpc3BsYXlU

ZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjE2Mzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzNDE3NjU1MSI+MjE2Mzg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPkFiZGVsaGFtaWQsIEFzbWFhIFMuPC9hdXRob3I+PGF1dGhvcj5Ccm93biwg

VHJhY2V5IEouPC9hdXRob3I+PGF1dGhvcj5CcmFpbmFyZCwgSnVsaWkgUy48L2F1dGhvcj48YXV0

aG9yPkJpc3dhcywgUHJpdGk8L2F1dGhvcj48YXV0aG9yPlRob3JwZSwgR2FicmllbGxlIEMuPC9h

dXRob3I+PGF1dGhvcj5Nb29yZSwgSGVsZW4gSi48L2F1dGhvcj48YXV0aG9yPkRlYW5lLCBLYXRo

ZXJpbmUgSG88L2F1dGhvcj48YXV0aG9yPkFsQWJkdWxnaGFmb29yLCBGYWkgSy48L2F1dGhvcj48

YXV0aG9yPlN1bW1lcmJlbGwsIENhcm9seW4gRC48L2F1dGhvcj48YXV0aG9yPldvcnRoaW5ndG9u

LCBIZWxlbiBWLjwvYXV0aG9yPjxhdXRob3I+U29uZywgRnVqaWFuPC9hdXRob3I+PGF1dGhvcj5I

b29wZXIsIExlZTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT5PbWVnYS0zIGZhdHR5IGFjaWRzIGZvciB0aGUgcHJpbWFyeSBhbmQgc2Vjb25kYXJ5IHByZXZl

bnRpb24gb2YgY2FyZGlvdmFzY3VsYXIgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5D

b2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0ZW1hdGljIFJldmlld3M8L3NlY29uZGFyeS10aXRsZT48

dGVydGlhcnktdGl0bGU+W1VwZGF0ZSBvZiBDb2NocmFuZSBEYXRhYmFzZSBTeXN0IFJldi4gMjAw

NCBPY3QgMTg7KDQpOkNEMDAzMTc3OyBQTUlEOiAxNTQ5NTA0NF08L3RlcnRpYXJ5LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNvY2hyYW5lIERhdGFiYXNlIG9mIFN5c3Rl

bWF0aWMgUmV2aWV3czwvZnVsbC10aXRsZT48YWJici0xPkNvY2hyYW5lIERhdGFiYXNlIFN5c3Qg

UmV2PC9hYmJyLTE+PGFiYnItMj5UaGUgQ29jaHJhbmUgZGF0YWJhc2Ugb2Ygc3lzdGVtYXRpYyBy

ZXZpZXdzPC9hYmJyLTI+PGFiYnItMz5Db2NocmFuZSBkYXRhYmFzZSBvZiBzeXN0ZW1hdGljIHJl

dmlld3MgKG9ubGluZSk8L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPkNEMDAzMTc3PC9wYWdl

cz48dm9sdW1lPjExPC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PC9kYXRlcz48cHVi

LWxvY2F0aW9uPkVuZ2xhbmQ8L3B1Yi1sb2NhdGlvbj48aXNibj4xNDY5LTQ5M1gmI3hEOzEzNjEt

NjEzNzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNv

bS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtQQUdFPXJlZmVyZW5jZSZhbXA7RD1wcmVtJmFtcDtORVdT

PU4mYW1wO0FOPTMwMDE5NzY2PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT5ET0k6IDEwLjEwMDIvMTQ2NTE4NTguQ0QwMDMxNzcucHViNDwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QWJkZWxoYW1p

ZDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT4yMTYzNzwvUmVjTnVtPjxyZWNvcmQ+

PHJlYy1udW1iZXI+MjE2Mzc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzNDE3NjU0NiI+MjE2Mzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkFiZGVsaGFtaWQsIEFzbWFhIFMuPC9hdXRob3I+PGF1dGhvcj5NYXJ0aW4sIE5pY29sZTwvYXV0

aG9yPjxhdXRob3I+QnJpZGdlcywgQ2hhcmxlbmU8L2F1dGhvcj48YXV0aG9yPkJyYWluYXJkLCBK

dWxpaSBTLjwvYXV0aG9yPjxhdXRob3I+V2FuZywgWGlhPC9hdXRob3I+PGF1dGhvcj5Ccm93biwg

VHJhY2V5IEouPC9hdXRob3I+PGF1dGhvcj5IYW5zb24sIFNhcmFoPC9hdXRob3I+PGF1dGhvcj5K

aW1vaCwgT2x1c2V5aSBGLjwvYXV0aG9yPjxhdXRob3I+QWphYm5vb3IsIFNhcmFoIE0uPC9hdXRo

b3I+PGF1dGhvcj5EZWFuZSwgS2F0aGVyaW5lIEhvPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBGdWpp

YW48L2F1dGhvcj48YXV0aG9yPkhvb3BlciwgTGVlPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp

YnV0b3JzPjx0aXRsZXM+PHRpdGxlPlBvbHl1bnNhdHVyYXRlZCBmYXR0eSBhY2lkcyBmb3IgdGhl

IHByaW1hcnkgYW5kIHNlY29uZGFyeSBwcmV2ZW50aW9uIG9mIGNhcmRpb3Zhc2N1bGFyIGRpc2Vh

c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q29jaHJhbmUgRGF0YWJhc2Ugb2YgU3lzdGVtYXRp

YyBSZXZpZXdzPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+Q29jaHJhbmUgRGF0YWJhc2Ugb2YgU3lzdGVtYXRpYyBSZXZpZXdzPC9mdWxsLXRpdGxlPjxh

YmJyLTE+Q29jaHJhbmUgRGF0YWJhc2UgU3lzdCBSZXY8L2FiYnItMT48YWJici0yPlRoZSBDb2No

cmFuZSBkYXRhYmFzZSBvZiBzeXN0ZW1hdGljIHJldmlld3M8L2FiYnItMj48YWJici0zPkNvY2hy

YW5lIGRhdGFiYXNlIG9mIHN5c3RlbWF0aWMgcmV2aWV3cyAob25saW5lKTwvYWJici0zPjwvcGVy

aW9kaWNhbD48cGFnZXM+Q0QwMTIzNDU8L3BhZ2VzPjx2b2x1bWU+MTE8L3ZvbHVtZT48ZGF0ZXM+

PHllYXI+MjAxODwveWVhcj48L2RhdGVzPjxwdWItbG9jYXRpb24+RW5nbGFuZDwvcHViLWxvY2F0

aW9uPjxpc2JuPjE0NjktNDkzWCYjeEQ7MTM2MS02MTM3PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVy

bHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO1BBR0U9

cmVmZXJlbmNlJmFtcDtEPXByZW0mYW1wO05FV1M9TiZhbXA7QU49MzAwMTk3Njc8L3VybD48L3Jl

bGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPkRPSTogMTAuMTAwMi8x

NDY1MTg1OC5DRDAxMjM0NS5wdWIzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48

L0NpdGU+PENpdGU+PEF1dGhvcj5Ib29wZXI8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO

dW0+MjE2Mzk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIxNjM5PC9yZWMtbnVtYmVyPjxm

b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0

YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1MzQxNzY1NTIiPjIxNjM5PC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ib29wZXIsIExlZTwvYXV0aG9yPjxhdXRob3I+QWwt

S2h1ZGFpcnksIExlbmE8L2F1dGhvcj48YXV0aG9yPkFiZGVsaGFtaWQsIEFzbWFhIFMuPC9hdXRo

b3I+PGF1dGhvcj5SZWVzLCBLYXJlbjwvYXV0aG9yPjxhdXRob3I+QnJhaW5hcmQsIEp1bGlpIFMu

PC9hdXRob3I+PGF1dGhvcj5Ccm93biwgVHJhY2V5IEouPC9hdXRob3I+PGF1dGhvcj5BamFibm9v

ciwgU2FyYWggTS48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztCcmllbiwgQWxleCBULjwvYXV0aG9y

PjxhdXRob3I+V2luc3RhbmxleSwgTGF1cmVuIEUuPC9hdXRob3I+PGF1dGhvcj5Eb25hbGRzb24s

IERhaXN5IEguPC9hdXRob3I+PGF1dGhvcj5Tb25nLCBGdWppYW48L2F1dGhvcj48YXV0aG9yPkRl

YW5lLCBLYXRoZXJpbmUgSG88L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxl

cz48dGl0bGU+T21lZ2EtNiBmYXRzIGZvciB0aGUgcHJpbWFyeSBhbmQgc2Vjb25kYXJ5IHByZXZl

bnRpb24gb2YgY2FyZGlvdmFzY3VsYXIgZGlzZWFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5D

b2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0ZW1hdGljIFJldmlld3M8L3NlY29uZGFyeS10aXRsZT48

dGVydGlhcnktdGl0bGU+W1VwZGF0ZSBvZiBDb2NocmFuZSBEYXRhYmFzZSBTeXN0IFJldi4gMjAx

NSBOb3YgMTY7KDExKTpDRDAxMTA5NDsgUE1JRDogMjY1NzE0NTFdPC90ZXJ0aWFyeS10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Db2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0

ZW1hdGljIFJldmlld3M8L2Z1bGwtdGl0bGU+PGFiYnItMT5Db2NocmFuZSBEYXRhYmFzZSBTeXN0

IFJldjwvYWJici0xPjxhYmJyLTI+VGhlIENvY2hyYW5lIGRhdGFiYXNlIG9mIHN5c3RlbWF0aWMg

cmV2aWV3czwvYWJici0yPjxhYmJyLTM+Q29jaHJhbmUgZGF0YWJhc2Ugb2Ygc3lzdGVtYXRpYyBy

ZXZpZXdzIChvbmxpbmUpPC9hYmJyLTM+PC9wZXJpb2RpY2FsPjxwYWdlcz5DRDAxMTA5NDwvcGFn

ZXM+PHZvbHVtZT4xMTwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDE4PC95ZWFyPjwvZGF0ZXM+PHB1

Yi1sb2NhdGlvbj5FbmdsYW5kPC9wdWItbG9jYXRpb24+PGlzYm4+MTQ2OS00OTNYJiN4RDsxMzYx

LTYxMzc8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j

b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7UEFHRT1yZWZlcmVuY2UmYW1wO0Q9cHJlbSZhbXA7TkVX

Uz1OJmFtcDtBTj0zMDAxOTc2NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+RE9JOiAxMC4xMDAyLzE0NjUxODU4LkNEMDExMDk0LnB1YjQ8L2VsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFiZGVsaGFt

aWQ8L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+MjIxNDU8L1JlY051bT48cmVjb3Jk

PjxyZWMtbnVtYmVyPjIyMTQ1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1NjQzMzA0MjgiPjIyMTQ1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5BYmRlbGhhbWlkLCBBc21hYTwvYXV0aG9yPjxhdXRob3I+SG9vcGVyLCBMZWU8L2F1dGhvcj48

YXV0aG9yPlNpdmFrYXJhbiwgUnVrc2FuYTwvYXV0aG9yPjxhdXRob3I+SGF5aG9lLCBSaWNoYXJk

IFAuIEcuPC9hdXRob3I+PGF1dGhvcj5XZWxjaCwgQWlsc2E8L2F1dGhvcj48YXV0aG9yPlRoZSBQ

VUZBSCBHcm91cCw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0

bGU+VGhlIFJlbGF0aW9uc2hpcCBCZXR3ZWVuIE9tZWdhLTMsIE9tZWdhLTYgYW5kIFRvdGFsIFBv

bHl1bnNhdHVyYXRlZCBGYXQgYW5kIE11c2N1bG9za2VsZXRhbCBIZWFsdGggYW5kIEZ1bmN0aW9u

YWwgU3RhdHVzIGluIEFkdWx0czogQSBTeXN0ZW1hdGljIFJldmlldyBhbmQgTWV0YS1hbmFseXNp

cyBvZiBSQ1RzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNhbGNpZmllZCBUaXNzdWUgSW50ZXJu

YXRpb25hbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkNhbGNpZmllZCBUaXNzdWUgSW50ZXJuYXRpb25hbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+

PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDE5LzA3LzI1PC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzMi0wODI3PC9pc2JuPjx1cmxzPjxyZWxhdGVk

LXVybHM+PHVybD5odHRwczovL2RvaS5vcmcvMTAuMTAwNy9zMDAyMjMtMDE5LTAwNTg0LTM8L3Vy

bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPkRPSTogMTAu

MTAwNy9zMDAyMjMtMDE5LTAwNTg0LTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJyYWluYXJkPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjIyMDMwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMjAzMDwvcmVjLW51bWJl

cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2

ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTUzOTQ0MDI3Ij4yMjAzMDwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnJhaW5hcmQsIEouPC9hdXRob3I+PGF1dGhv

cj5KaW1vaCwgTy5GLjwvYXV0aG9yPjxhdXRob3I+RGVhbmUsIEsuPC9hdXRob3I+PGF1dGhvcj5C

aXN3YXMsIFAuPC9hdXRob3I+PGF1dGhvcj5Eb25hbGRzb24sIEQuPC9hdXRob3I+PGF1dGhvcj5N

YWFzLCBLLjwvYXV0aG9yPjxhdXRob3I+QWJkZWxoYW1pZCwgQS48L2F1dGhvcj48YXV0aG9yPkhv

b3BlciwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

T21lZ2EtMywgb21lZ2EtNiBhbmQgdG90YWwgcG9seXVuc2F0dXJhdGVkIGZhdCBmb3IgY29nbml0

aW9uIGFuZCBkZW1lbnRpYTogU3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMgb2Yg

UkNUczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5zdWJtaXR0ZWQ8L3NlY29uZGFyeS10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5zdWJtaXR0ZWQ8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJyb3duPC9BdXRob3I+PFllYXI+MjAxOTwvWWVh

cj48UmVjTnVtPjIyMTkyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yMjE5MjwvcmVjLW51

bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVl

MGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTY4MDMzMDkxIj4yMjE5Mjwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QnJvd24sIFRyYWNleSBKPC9hdXRob3I+

PGF1dGhvcj5CcmFpbmFyZCwgSnVsaWk8L2F1dGhvcj48YXV0aG9yPlNvbmcsIEZ1amlhbjwvYXV0

aG9yPjxhdXRob3I+V2FuZywgWGlhPC9hdXRob3I+PGF1dGhvcj5BYmRlbGhhbWlkLCBBc21hYTwv

YXV0aG9yPjxhdXRob3I+SG9vcGVyLCBMZWU8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PHRpdGxlcz48dGl0bGU+T21lZ2EtMywgb21lZ2EtNiwgYW5kIHRvdGFsIGRpZXRhcnkgcG9s

eXVuc2F0dXJhdGVkIGZhdCBmb3IgcHJldmVudGlvbiBhbmQgdHJlYXRtZW50IG9mIHR5cGUgMiBk

aWFiZXRlcyBtZWxsaXR1czogc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMgb2Yg

cmFuZG9taXNlZCBjb250cm9sbGVkIHRyaWFsczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CTUo8

L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Ccml0aXNo

IE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkJyIE1lZCBKPC9hYmJyLTE+PGFi

YnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+

bDQ2OTc8L3BhZ2VzPjx2b2x1bWU+MzY2PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+

PC9kYXRlcz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cuYm1qLmNvbS9jb250

ZW50L2Jtai8zNjYvYm1qLmw0Njk3LmZ1bGwucGRmPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5ET0k6IDEwLjExMzYvYm1qLmw0Njk3PC9lbGVjdHJv

bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYW5zb248L0F1

dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+MjIxMzg8L1JlY051bT48cmVjb3JkPjxyZWMt

bnVtYmVyPjIyMTM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NjI2

MTE2ODciPjIyMTM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYW5z

b24sIFMuPC9hdXRob3I+PGF1dGhvcj5UaG9ycGUsIEcuPC9hdXRob3I+PGF1dGhvcj5XaW5zdGFu

bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+QWJkZWxoYW1pZCwgQS5TLjwvYXV0aG9yPjxhdXRob3I+

SG9vcGVyLCBMLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRs

ZT5PbWVnYS0zLCBvbWVnYS02IGFuZCB0b3RhbCBkaWV0YXJ5IHBvbHl1bnNhdHVyYXRlZCBmYXQg

b24gY2FuY2VyIGluY2lkZW5jZTogc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXMg

b2YgcmFuZG9taXNlZCB0cmlhbHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+c3VibWl0dGVkPC9z

ZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+c3VibWl0dGVk

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48L2RhdGVz

Pjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Ib29wZXI8L0F1dGhv

cj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNOdW0+MjE2OTc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjIxNjk3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i

NTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1NDEyNDE4

ODQiPjIxNjk3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ib29wZXIs

IExlZTwvYXV0aG9yPjxhdXRob3I+QWJkZWxoYW1pZCwgQXNtYWE8L2F1dGhvcj48YXV0aG9yPkJy

YWluYXJkLCBKdWxpaTwvYXV0aG9yPjxhdXRob3I+RGVhbmUsIEthdGhlcmluZSBILiBPLjwvYXV0

aG9yPjxhdXRob3I+U29uZywgRnVqaWFuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

Pjx0aXRsZXM+PHRpdGxlPkNyZWF0aW9uIG9mIGEgZGF0YWJhc2UgdG8gYXNzZXNzIGVmZmVjdHMg

b2Ygb21lZ2EtMywgb21lZ2EtNiBhbmQgdG90YWwgcG9seXVuc2F0dXJhdGVkIGZhdHMgb24gaGVh

bHRoOiBkYXRhYmFzZSBhbmQgbWV0aG9kb2xvZ3kgZm9yIGEgc2V0IG9mIHJldmlld3M8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+Qk1KIE9wZW4gPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1KIE9wZW48L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUogT3Bl

bjwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTAyOTU1NDwvcGFnZXM+PHZvbHVtZT45PC92

b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTk8L3llYXI+PC9kYXRlcz48

dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2Jtam9wZW4uYm1qLmNvbS9jb250ZW50Lzkv

NS9lMDI5NTU0LmFic3RyYWN0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT5ET0k6IDEwLjExMzYvYm1qb3Blbi0yMDE5LTAyOTU1NDwvZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+VGhvcnBlPC9BdXRo

b3I+PFllYXI+MjAxNzwvWWVhcj48UmVjTnVtPjE4ODU4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51

bWJlcj4xODg1ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIxNTMwMzUz

NTU2Ij4xODg1ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy

dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGhvcnBl

LCBHLjwvYXV0aG9yPjxhdXRob3I+QWphYm5vb3IsIFMuPC9hdXRob3I+PGF1dGhvcj5BaG1lZCwg

Wi48L2F1dGhvcj48YXV0aG9yPkFiZGVsaGFtaWQsIEEuPC9hdXRob3I+PGF1dGhvcj5Ib29wZXIs

IEwuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkRpZXRh

cnkgcG9seXVuc2F0dXJhdGVkIGZhdCBmb3IgcHJldmVudGlvbiBhbmQgdHJlYXRtZW50IG9mIGlu

ZmxhbW1hdG9yeSBib3dlbCBkaXNlYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBST1NQRVJP

PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UFJPU1BF

Uk88L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz5DUkQ0MjAxNzA2ODcwNDwvcGFnZXM+

PGRhdGVzPjx5ZWFyPjIwMTc8L3llYXI+PC9kYXRlcz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

d3d3LmNyZC55b3JrLmFjLnVrL3Byb3NwZXJvL2Rpc3BsYXlfcmVjb3JkLnBocD9SZWNvcmRJRD02

ODcwNDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3Rl

PgB=

ADDIN EN.CITE.DATA (1, 42-49)There was little or no effect of being randomised to increased ALA on gastrointestinal side effects, but fewer dropouts due to adverse side effects (Supplementary Table 9). Trials of omega-6 and total PUFA did not provide data on secondary outcomes. Ongoing trialsWe identified eleven ongoing trials of polyunsaturated fats that appear likely to have assessed depression or anxiety outcomes (detailed in Supplementary Table 10). Some are overdue for publication and may constitute missing data, others are due to complete and be published over the next few years. Supplementary Table 1. Brief characteristics of included studies StudyPopulation, countryIntervention ComparisonParticipants randomisedTrial DurationAlphaOmega – Kromhout 2010 ALAPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzNCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+R2VsZWlqbnNlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0MTA8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxMjM5NyI+NTQxMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+R2VsZWlqbnNlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLjwvYXV0

aG9yPjxhdXRob3I+S3JvbWhvdXQsIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+KEdlbGVpam5zZSwgS3JvbWhvdXQpIFdhZ2VuaW5nZW4gVW5pdmVyc2l0

eSwgV2FnZW5pbmdlbiwgTmV0aGVybGFuZHMgKEdpbHRheSkgTGVpZGVuIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIsIExlaWRlbiwgTmV0aGVybGFuZHMgSi4gR2VsZWlqbnNlLCBXYWdlbmluZ2Vu

IFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIE5ldGhlcmxhbmRzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0cyBvZiBuLTMgZmF0dHlhY2lkcyBvbiBjb2duaXRpdmUgZGVjbGluZTog

QSByYW5kb21pemVkIGRvdWJsZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIGluIHN0

YWJsZSBteW9jYXJkaWFsIGluZmFyY3Rpb24gcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJi

ci0yPkFsemhlaW1lciZhcG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWlt

ZXJzIGFuZCBEZW1lbnRpYTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+UzUxMjwvcGFnZXM+

PHZvbHVtZT4xKTwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+cGF0aWVudCBodW1hbiBjb250cm9sbGVkIHN0dWR5

IGhlYXJ0IGluZmFyY3Rpb24gTWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gc3VwcGxlbWVu

dGF0aW9uIGNvZ25pdGlvbiBtZW50YWwgaGVhbHRoIGV4YW1pbmF0aW9uIGZvbGxvdyB1cCBnZW5k

ZXIgbG93IGRydWcgZG9zZSB2ZWdldGFibGUgaXNjaGVtaWMgaGVhcnQgZGlzZWFzZSBtYWxlIGNh

cmRpb3Zhc2N1bGFyIGRpc2Vhc2UgZmlzaCBmYWN0b3JpYWwgZGVzaWduIGNvaG9ydCBhbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01MjYwPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMS4wNS4xNDMyO0NvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMCZhbXA7QU49NzA1

MDIxMzRodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtp

ZD1wbWlkOiZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmphbHouMjAxMS4wNS4xNDMyJmFtcDtpc3Nu

PTE1NTItNTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT03JmFtcDtpc3N1ZT00K1NVUFBMLisxJmFt

cDtzcGFnZT1TNTEyJmFtcDtwYWdlcz1TNTEyJmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUFsemhl

aW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHlhY2lk

cytvbitjb2duaXRpdmUrZGVjbGluZSUzQStBK3JhbmRvbWl6ZWQrZG91YmxlLWJsaW5kJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtpbitzdGFibGUrbXlvY2FyZGlhbCtpbmZhcmN0aW9uK3Bh

dGllbnRzJmFtcDthdWxhc3Q9R2VsZWlqbnNlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzNCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+R2VsZWlqbnNlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0MTA8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxMjM5NyI+NTQxMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+R2VsZWlqbnNlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLjwvYXV0

aG9yPjxhdXRob3I+S3JvbWhvdXQsIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+KEdlbGVpam5zZSwgS3JvbWhvdXQpIFdhZ2VuaW5nZW4gVW5pdmVyc2l0

eSwgV2FnZW5pbmdlbiwgTmV0aGVybGFuZHMgKEdpbHRheSkgTGVpZGVuIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIsIExlaWRlbiwgTmV0aGVybGFuZHMgSi4gR2VsZWlqbnNlLCBXYWdlbmluZ2Vu

IFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIE5ldGhlcmxhbmRzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0cyBvZiBuLTMgZmF0dHlhY2lkcyBvbiBjb2duaXRpdmUgZGVjbGluZTog

QSByYW5kb21pemVkIGRvdWJsZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIGluIHN0

YWJsZSBteW9jYXJkaWFsIGluZmFyY3Rpb24gcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJi

ci0yPkFsemhlaW1lciZhcG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWlt

ZXJzIGFuZCBEZW1lbnRpYTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+UzUxMjwvcGFnZXM+

PHZvbHVtZT4xKTwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+cGF0aWVudCBodW1hbiBjb250cm9sbGVkIHN0dWR5

IGhlYXJ0IGluZmFyY3Rpb24gTWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gc3VwcGxlbWVu

dGF0aW9uIGNvZ25pdGlvbiBtZW50YWwgaGVhbHRoIGV4YW1pbmF0aW9uIGZvbGxvdyB1cCBnZW5k

ZXIgbG93IGRydWcgZG9zZSB2ZWdldGFibGUgaXNjaGVtaWMgaGVhcnQgZGlzZWFzZSBtYWxlIGNh

cmRpb3Zhc2N1bGFyIGRpc2Vhc2UgZmlzaCBmYWN0b3JpYWwgZGVzaWduIGNvaG9ydCBhbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01MjYwPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMS4wNS4xNDMyO0NvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMCZhbXA7QU49NzA1

MDIxMzRodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtp

ZD1wbWlkOiZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmphbHouMjAxMS4wNS4xNDMyJmFtcDtpc3Nu

PTE1NTItNTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT03JmFtcDtpc3N1ZT00K1NVUFBMLisxJmFt

cDtzcGFnZT1TNTEyJmFtcDtwYWdlcz1TNTEyJmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUFsemhl

aW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHlhY2lk

cytvbitjb2duaXRpdmUrZGVjbGluZSUzQStBK3JhbmRvbWl6ZWQrZG91YmxlLWJsaW5kJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtpbitzdGFibGUrbXlvY2FyZGlhbCtpbmZhcmN0aW9uK3Bh

dGllbnRzJmFtcDthdWxhc3Q9R2VsZWlqbnNlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (2, 34)60-80 year olds with previous myocardial infarction, NetherlandsALA-rich supplementary margarine, 2 g ALA/dALA vs MUFA2409 int, 2428 cont3.3 yearsAlphaOmega – Kromhout 2010 EPA & DHAPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzNCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+R2VsZWlqbnNlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0MTA8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxMjM5NyI+NTQxMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+R2VsZWlqbnNlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLjwvYXV0

aG9yPjxhdXRob3I+S3JvbWhvdXQsIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+KEdlbGVpam5zZSwgS3JvbWhvdXQpIFdhZ2VuaW5nZW4gVW5pdmVyc2l0

eSwgV2FnZW5pbmdlbiwgTmV0aGVybGFuZHMgKEdpbHRheSkgTGVpZGVuIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIsIExlaWRlbiwgTmV0aGVybGFuZHMgSi4gR2VsZWlqbnNlLCBXYWdlbmluZ2Vu

IFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIE5ldGhlcmxhbmRzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0cyBvZiBuLTMgZmF0dHlhY2lkcyBvbiBjb2duaXRpdmUgZGVjbGluZTog

QSByYW5kb21pemVkIGRvdWJsZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIGluIHN0

YWJsZSBteW9jYXJkaWFsIGluZmFyY3Rpb24gcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJi

ci0yPkFsemhlaW1lciZhcG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWlt

ZXJzIGFuZCBEZW1lbnRpYTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+UzUxMjwvcGFnZXM+

PHZvbHVtZT4xKTwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+cGF0aWVudCBodW1hbiBjb250cm9sbGVkIHN0dWR5

IGhlYXJ0IGluZmFyY3Rpb24gTWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gc3VwcGxlbWVu

dGF0aW9uIGNvZ25pdGlvbiBtZW50YWwgaGVhbHRoIGV4YW1pbmF0aW9uIGZvbGxvdyB1cCBnZW5k

ZXIgbG93IGRydWcgZG9zZSB2ZWdldGFibGUgaXNjaGVtaWMgaGVhcnQgZGlzZWFzZSBtYWxlIGNh

cmRpb3Zhc2N1bGFyIGRpc2Vhc2UgZmlzaCBmYWN0b3JpYWwgZGVzaWduIGNvaG9ydCBhbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01MjYwPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMS4wNS4xNDMyO0NvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMCZhbXA7QU49NzA1

MDIxMzRodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtp

ZD1wbWlkOiZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmphbHouMjAxMS4wNS4xNDMyJmFtcDtpc3Nu

PTE1NTItNTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT03JmFtcDtpc3N1ZT00K1NVUFBMLisxJmFt

cDtzcGFnZT1TNTEyJmFtcDtwYWdlcz1TNTEyJmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUFsemhl

aW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHlhY2lk

cytvbitjb2duaXRpdmUrZGVjbGluZSUzQStBK3JhbmRvbWl6ZWQrZG91YmxlLWJsaW5kJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtpbitzdGFibGUrbXlvY2FyZGlhbCtpbmZhcmN0aW9uK3Bh

dGllbnRzJmFtcDthdWxhc3Q9R2VsZWlqbnNlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lcm9taG91dDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+

PFJlY051bT44NjMxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzNCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+ODYzMTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjE0MjExIj44NjMxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Lcm9taG91dCwgRC48L2F1dGhvcj48YXV0aG9yPkdpbHRheSwgRS4gSi48L2F1dGhvcj48

YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48L2F1dGhvcj48YXV0aG9yPkFscGhhIE9tZWdhIFRyaWFs

IEdyb3VwLDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkty

b21ob3V0LERhYW4uIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5pbmdlbiBVbml2

ZXJzaXR5LCBXYWdlbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMuIGRhYW4ua3JvbWhvdXRAd3VyLm5s

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+bi0zIGZhdHR5IGFjaWRzIGFuZCBjYXJkaW92

YXNjdWxhciBldmVudHMgYWZ0ZXIgbXlvY2FyZGlhbCBpbmZhcmN0aW9uPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPk4gRW5nbCBKIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPk5ldyBFbmdsYW5kIEpvdXJuYWwgb2YgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OIEVuZ2wgSiBNZWQ8L2FiYnItMT48YWJici0yPk5FSk08L2FiYnItMj48YWJici0z

PlRoZSBOZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9hYmJyLTM+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGlj

aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+TiBFbmdsIEogTWVkPC9hYmJyLTE+PGFiYnItMj5ORUpN

PC9hYmJyLTI+PGFiYnItMz5UaGUgTmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvYWJi

ci0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwMTUtMjAyNjwvcGFnZXM+PHZvbHVtZT4zNjM8

L3ZvbHVtZT48bnVtYmVyPjIxPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwv

cmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIg

Q2FyZGlvdmFzY3VsYXIgRGlzZWFzZXMvZXAgW0VwaWRlbWlvbG9neV0gKkNhcmRpb3Zhc2N1bGFy

IERpc2Vhc2VzL3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdIERvY29zYWhleGFl

bm9pYyBBY2lkcy90dSBbVGhlcmFwZXV0aWMgVXNlXSBEb3VibGUtQmxpbmQgTWV0aG9kIERydWcg

VGhlcmFweTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0

ZXM+PGlzYm4+MTUzMy00NDA2PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAu

MTA1Ni9ORUpNb2ExMDAzNjAzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxl

ZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwgUmVzZWFyY2ggU3Vw

cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt

cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA5MjkzNDFodHRw

Oi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoy

MDkyOTM0MSZhbXA7aWQ9ZG9pOjEwLjEwNTYlMkZORUpNb2ExMDAzNjAzJmFtcDtpc3NuPTAwMjgt

NDc5MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zNjMmYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMDE1

JmFtcDtwYWdlcz0yMDE1LTI2JmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pv

dXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1uLTMrZmF0dHkrYWNpZHMrYW5kK2NhcmRpb3Zh

c2N1bGFyK2V2ZW50cythZnRlcitteW9jYXJkaWFsK2luZmFyY3Rpb24uJmFtcDthdWxhc3Q9S3Jv

bWhvdXQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB

dXRob3I+R2VsZWlqbnNlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0MTA8L1Jl

Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQi

IHRpbWVzdGFtcD0iMTUzMDIxMjM5NyI+NTQxMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+R2VsZWlqbnNlLCBKLjwvYXV0aG9yPjxhdXRob3I+R2lsdGF5LCBFLjwvYXV0

aG9yPjxhdXRob3I+S3JvbWhvdXQsIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+KEdlbGVpam5zZSwgS3JvbWhvdXQpIFdhZ2VuaW5nZW4gVW5pdmVyc2l0

eSwgV2FnZW5pbmdlbiwgTmV0aGVybGFuZHMgKEdpbHRheSkgTGVpZGVuIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIsIExlaWRlbiwgTmV0aGVybGFuZHMgSi4gR2VsZWlqbnNlLCBXYWdlbmluZ2Vu

IFVuaXZlcnNpdHksIFdhZ2VuaW5nZW4sIE5ldGhlcmxhbmRzPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0cyBvZiBuLTMgZmF0dHlhY2lkcyBvbiBjb2duaXRpdmUgZGVjbGluZTog

QSByYW5kb21pemVkIGRvdWJsZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIGluIHN0

YWJsZSBteW9jYXJkaWFsIGluZmFyY3Rpb24gcGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QWx6aGVpbWVyJmFwb3M7cyBhbmQgRGVtZW50aWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJi

ci0yPkFsemhlaW1lciZhcG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWlt

ZXJzIGFuZCBEZW1lbnRpYTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+UzUxMjwvcGFnZXM+

PHZvbHVtZT4xKTwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+cGF0aWVudCBodW1hbiBjb250cm9sbGVkIHN0dWR5

IGhlYXJ0IGluZmFyY3Rpb24gTWluaSBNZW50YWwgU3RhdGUgRXhhbWluYXRpb24gc3VwcGxlbWVu

dGF0aW9uIGNvZ25pdGlvbiBtZW50YWwgaGVhbHRoIGV4YW1pbmF0aW9uIGZvbGxvdyB1cCBnZW5k

ZXIgbG93IGRydWcgZG9zZSB2ZWdldGFibGUgaXNjaGVtaWMgaGVhcnQgZGlzZWFzZSBtYWxlIGNh

cmRpb3Zhc2N1bGFyIGRpc2Vhc2UgZmlzaCBmYWN0b3JpYWwgZGVzaWduIGNvaG9ydCBhbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01MjYwPC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMS4wNS4xNDMyO0NvbmZlcmVuY2UgQWJzdHJhY3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl

ZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMCZhbXA7QU49NzA1

MDIxMzRodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6ZW1iYXNlJmFtcDtp

ZD1wbWlkOiZhbXA7aWQ9ZG9pOjEwLjEwMTYlMkZqLmphbHouMjAxMS4wNS4xNDMyJmFtcDtpc3Nu

PTE1NTItNTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT03JmFtcDtpc3N1ZT00K1NVUFBMLisxJmFt

cDtzcGFnZT1TNTEyJmFtcDtwYWdlcz1TNTEyJmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUFsemhl

aW1lciUyN3MrYW5kK0RlbWVudGlhJmFtcDthdGl0bGU9RWZmZWN0cytvZituLTMrZmF0dHlhY2lk

cytvbitjb2duaXRpdmUrZGVjbGluZSUzQStBK3JhbmRvbWl6ZWQrZG91YmxlLWJsaW5kJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtpbitzdGFibGUrbXlvY2FyZGlhbCtpbmZhcmN0aW9uK3Bh

dGllbnRzJmFtcDthdWxhc3Q9R2VsZWlqbnNlPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (2, 34)60-80 year olds with previous myocardial infarction, NetherlandsEPA & DHA-rich supplementary margarine, 0.24 g/d EPA & 0.16g/d DHALCn3 vs MUFA2404 int, 2433 cont3.3 yearsAREDS2 2014PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

TnVtPjI4MzA8L1JlY051bT48RGlzcGxheVRleHQ+KDMpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hl

dywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+PGF1dGhvcj5B

Z3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48YXV0aG9yPkdy

b2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1dGhvcj48YXV0

aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24gb2YgRXBpZGVt

aW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gs

IE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJl

dGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29ycG9yYXRpb24s

IFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2YgRXBpZGVtaW9s

b2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gsIE5h

dGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhl

c2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9neSBTZWN0aW9u

LCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBhcnRtZW50IG9m

IE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVk

aWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9mIEVwaWRlbWlv

bG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBNYXNzYWNodXNl

dHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIFV0

YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9m

IE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhlciBOdXRyaWVu

dCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJFRFMyIFJhbmRv

bWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGljYWwgQXNzb2Np

YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBNZWRp

Y2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0xPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1bWU+PG51bWJl

cj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3JpdGhtcyBBc2Nv

cmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2duaXRpb24gQ29u

dGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w

OyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWQg

W0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhvZCAqRWljb3Nh

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAxL2ph

bWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpT

JmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FO

PTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUm

YW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4yMDE1Ljk2Nzcm

YW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7aXNzdWU9OCZh

bXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1wO3RpdGxlPUpB

TUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytMdXRlaW4lMkZa

ZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitvbitDb2duaXRp

dmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1RyaWFsLiZhbXA7

YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGV3PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48UmVj

TnVtPjI4MzA8L1JlY051bT48RGlzcGxheVRleHQ+KDMpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjI4MzA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxMDk4MiI+MjgzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2hl

dywgRS4gWS48L2F1dGhvcj48YXV0aG9yPkNsZW1vbnMsIFQuIEUuPC9hdXRob3I+PGF1dGhvcj5B

Z3JvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxhdW5lciwgTC4gSi48L2F1dGhvcj48YXV0aG9yPkdy

b2RzdGVpbiwgRi48L2F1dGhvcj48YXV0aG9yPkJlcm5zdGVpbiwgUC4gUy48L2F1dGhvcj48YXV0

aG9yPkFnZS1SZWxhdGVkIEV5ZSBEaXNlYXNlLCBTdHVkeTwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNoZXcsRW1pbHkgWS4gRGl2aXNpb24gb2YgRXBpZGVt

aW9sb2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gs

IE5hdGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJl

dGhlc2RhLCBNYXJ5bGFuZC4gQ2xlbW9ucyxUcmFjaSBFLiBUaGUgRU1NRVMgQ29ycG9yYXRpb24s

IFJvY2t2aWxsZSwgTWFyeWxhbmQuIEFncm9uLEVsdmlyYS4gRGl2aXNpb24gb2YgRXBpZGVtaW9s

b2d5IGFuZCBDbGluaWNhbCBBcHBsaWNhdGlvbnMsIENsaW5pY2FsIFRyaWFscyBCcmFuY2gsIE5h

dGlvbmFsIEV5ZSBJbnN0aXR1dGUvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFsdGgsIEJldGhl

c2RhLCBNYXJ5bGFuZC4gTGF1bmVyLExlbm9yZSBKLiBOZXVyb2VwaWRlbWlvbG9neSBTZWN0aW9u

LCBOYXRpb25hbCBJbnN0aXR1dGUgb24gQWdpbmcvTmF0aW9uYWwgSW5zdGl0dXRlcyBvZiBIZWFs

dGgsIEJldGhlc2RhLCBNYXJ5bGFuZC4gR3JvZHN0ZWluLEZyYW5jaW5lLiBEZXBhcnRtZW50IG9m

IE1lZGljaW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwsIEhhcnZhcmQgTWVk

aWNhbCBTY2hvb2wsIEJvc3RvbiwgTWFzc2FjaHVzZXR0czVEZXBhcnRtZW50IG9mIEVwaWRlbWlv

bG9neSwgSGFydmFyZCBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCwgQm9zdG9uLCBNYXNzYWNodXNl

dHRzLiBCZXJuc3RlaW4sUGF1bCBTLiBNb3JhbiBFeWUgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIFV0

YWgsIFNhbHQgTGFrZSBDaXR5PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9m

IE9tZWdhLTMgRmF0dHkgQWNpZHMsIEx1dGVpbi9aZWF4YW50aGluLCBvciBPdGhlciBOdXRyaWVu

dCBTdXBwbGVtZW50YXRpb24gb24gQ29nbml0aXZlIEZ1bmN0aW9uOiBUaGUgQVJFRFMyIFJhbmRv

bWl6ZWQgQ2xpbmljYWwgVHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFNQTwvc2Vjb25k

YXJ5LXRpdGxlPjxhbHQtdGl0bGU+SmFtYTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkpBTUE6IEpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIE1lZGljYWwgQXNzb2Np

YXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5KQU1BPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KQU1BOiBKb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBNZWRp

Y2FsIEFzc29jaWF0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+SkFNQTwvYWJici0xPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjc5MS04MDE8L3BhZ2VzPjx2b2x1bWU+MzE0PC92b2x1bWU+PG51bWJl

cj44PC9udW1iZXI+PHJlcHJpbnQtZWRpdGlvbj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFnZWQsODAgYW5kIG92ZXIgQWxnb3JpdGhtcyBBc2Nv

cmJpYyBBY2lkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpDb2duaXRpb24gQ29u

dGluZW50YWwgUG9wdWxhdGlvbiBHcm91cHMgQ29wcGVyL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w

OyBEb3NhZ2VdICpEaWV0YXJ5IFN1cHBsZW1lbnRzICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvYWQg

W0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRG91YmxlLUJsaW5kIE1ldGhvZCAqRWljb3Nh

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTM4LTM1OTg8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAxL2ph

bWEuMjAxNS45Njc3O011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEludHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48

cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpT

JmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FO

PTI2MzA1NjQ5aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUm

YW1wO2lkPXBtaWQ6MjYzMDU2NDkmYW1wO2lkPWRvaToxMC4xMDAxJTJGamFtYS4yMDE1Ljk2Nzcm

YW1wO2lzc249MDA5OC03NDg0JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxNCZhbXA7aXNzdWU9OCZh

bXA7c3BhZ2U9NzkxJmFtcDtwYWdlcz03OTEtODAxJmFtcDtkYXRlPTIwMTUmYW1wO3RpdGxlPUpB

TUEmYW1wO2F0aXRsZT1FZmZlY3Qrb2YrT21lZ2EtMytGYXR0eStBY2lkcyUyQytMdXRlaW4lMkZa

ZWF4YW50aGluJTJDK29yK090aGVyK051dHJpZW50K1N1cHBsZW1lbnRhdGlvbitvbitDb2duaXRp

dmUrRnVuY3Rpb24lM0ErVGhlK0FSRURTMitSYW5kb21pemVkK0NsaW5pY2FsK1RyaWFsLiZhbXA7

YXVsYXN0PUNoZXc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwv

RW5kTm90ZT5=

ADDIN EN.CITE.DATA (3)50-85 year olds at high risk of progression to advanced age-related macular degeneration, USAEPA & DHA supplement, 0.65g/d EPA & 0.35 g/d DHALCn3 vs nil2157 int, 2046 cont5 yearsASCEND 2018 ADDIN EN.CITE <EndNote><Cite><Author>ASCEND Study Collaborative Group</Author><Year>2018</Year><RecNum>21701</RecNum><DisplayText>(4)</DisplayText><record><rec-number>21701</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1542140629">21701</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>ASCEND Study Collaborative Group,</author></authors></contributors><titles><title>Effects of n?3 Fatty Acid Supplements in Diabetes Mellitus</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N Engl J Med</abbr-1><abbr-2>NEJM</abbr-2><abbr-3>The New England Journal of Medicine</abbr-3></periodical><pages>1540-1550</pages><volume>379</volume><number>16</number><dates><year>2018</year><pub-dates><date>2018/10/18</date></pub-dates></dates><publisher>Massachusetts Medical Society</publisher><isbn>0028-4793</isbn><urls><related-urls><url>;(4)Patients with diabetes, without apparent vascular disease, UKEPA & DHA supplement, 0.46g/d EPA & 0.38 g/d DHALCn3 vs MUFA7740 int, 7740 cont7.4 yearsChiu 2008PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGl1PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVj

TnVtPjI4NjI8L1JlY051bT48RGlzcGxheVRleHQ+KDE1KTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4yODYyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAyMTEwMDAiPjI4NjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNo

aXUsIEMuIEMuPC9hdXRob3I+PGF1dGhvcj5TdSwgSy4gUC48L2F1dGhvcj48YXV0aG9yPkNoZW5n

LCBULiBDLjwvYXV0aG9yPjxhdXRob3I+TGl1LCBILiBDLjwvYXV0aG9yPjxhdXRob3I+Q2hhbmcs

IEMuIEouPC9hdXRob3I+PGF1dGhvcj5EZXdleSwgTS4gRS48L2F1dGhvcj48YXV0aG9yPlN0ZXdh

cnQsIFIuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywgUy4gWS48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DaGl1LENoaWgtQ2hpYW5nLiBEZXBhcnRtZW50IG9m

IFBzeWNoaWF0cnksIFRhaXBlaSBDaXR5IFBzeWNoaWF0cmljIENlbnRlciwgVGFpcGVpIENpdHkg

SG9zcGl0YWwsIERlcGFydG1lbnQgb2YgUHN5Y2hpYXRyeSwgVGFpcGVpIE1lZGljYWwgVW5pdmVy

c2l0eSwgVGFpcGVpLCBUYWl3YW48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgZWZm

ZWN0cyBvZiBvbWVnYS0zIGZhdHR5IGFjaWRzIG1vbm90aGVyYXB5IGluIEFsemhlaW1lciZhcG9z

O3MgZGlzZWFzZSBhbmQgbWlsZCBjb2duaXRpdmUgaW1wYWlybWVudDogYSBwcmVsaW1pbmFyeSBy

YW5kb21pemVkIGRvdWJsZS1ibGluZCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1ZHk8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+UHJvZ3Jlc3MgaW4gTmV1cm8tUHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7

IEJpb2xvZ2ljYWwgUHN5Y2hpYXRyeTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHJvZyBO

ZXVyb3BzeWNob3BoYXJtYWNvbCBCaW9sIFBzeWNoaWF0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Qcm9ncmVzcyBpbiBOZXVyby1Qc3ljaG9waGFybWFjb2xv

Z3kgJmFtcDsgQmlvbG9naWNhbCBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBO

ZXVyb3BzeWNob3BoYXJtYWNvbCBCaW9sIFBzeWNoaWF0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+

PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlByb2dyZXNzIGluIE5ldXJvLVBzeWNob3BoYXJt

YWNvbG9neSAmYW1wOyBCaW9sb2dpY2FsIFBzeWNoaWF0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5Q

cm9nIE5ldXJvcHN5Y2hvcGhhcm1hY29sIEJpb2wgUHN5Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjE1MzgtMTU0NDwvcGFnZXM+PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1i

ZXI+NjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlv

bj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFsemhlaW1lciBEaXNl

YXNlL2JsIFtCbG9vZF0gKkFsemhlaW1lciBEaXNlYXNlL2R0IFtEcnVnIFRoZXJhcHldIEFsemhl

aW1lciBEaXNlYXNlL3B4IFtQc3ljaG9sb2d5XSBDb2duaXRpb24gRGlzb3JkZXJzL2JsIFtCbG9v

ZF0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZHQgW0RydWcgVGhlcmFweV0gQ29nbml0aW9uIERpc29y

ZGVycy9weCBbUHN5Y2hvbG9neV0gRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvczwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MDI3OC01ODQ2

PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnBucGJwLjIwMDgu

MDUuMDE1O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24t

VS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZh

bXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODU3MzU4NWh0dHA6Ly9zZngudWNs

LmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NTczNTg1JmFt

cDtpZD1kb2k6MTAuMTAxNiUyRmoucG5wYnAuMjAwOC4wNS4wMTUmYW1wO2lzc249MDI3OC01ODQ2

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMyJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT0xNTM4JmFtcDtw

YWdlcz0xNTM4LTQ0JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPVByb2dyZXNzK2luK05ldXJvLVBz

eWNob3BoYXJtYWNvbG9neSslMjYrQmlvbG9naWNhbCtQc3ljaGlhdHJ5JmFtcDthdGl0bGU9VGhl

K2VmZmVjdHMrb2Yrb21lZ2EtMytmYXR0eSthY2lkcyttb25vdGhlcmFweStpbitBbHpoZWltZXIl

MjdzK2Rpc2Vhc2UrYW5kK21pbGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYStwcmVsaW1pbmFy

eStyYW5kb21pemVkK2RvdWJsZS1ibGluZCtwbGFjZWJvLWNvbnRyb2xsZWQrc3R1ZHkuJmFtcDth

dWxhc3Q9Q2hpdTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGl1PC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVj

TnVtPjI4NjI8L1JlY051bT48RGlzcGxheVRleHQ+KDE1KTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4yODYyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAyMTEwMDAiPjI4NjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNo

aXUsIEMuIEMuPC9hdXRob3I+PGF1dGhvcj5TdSwgSy4gUC48L2F1dGhvcj48YXV0aG9yPkNoZW5n

LCBULiBDLjwvYXV0aG9yPjxhdXRob3I+TGl1LCBILiBDLjwvYXV0aG9yPjxhdXRob3I+Q2hhbmcs

IEMuIEouPC9hdXRob3I+PGF1dGhvcj5EZXdleSwgTS4gRS48L2F1dGhvcj48YXV0aG9yPlN0ZXdh

cnQsIFIuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywgUy4gWS48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DaGl1LENoaWgtQ2hpYW5nLiBEZXBhcnRtZW50IG9m

IFBzeWNoaWF0cnksIFRhaXBlaSBDaXR5IFBzeWNoaWF0cmljIENlbnRlciwgVGFpcGVpIENpdHkg

SG9zcGl0YWwsIERlcGFydG1lbnQgb2YgUHN5Y2hpYXRyeSwgVGFpcGVpIE1lZGljYWwgVW5pdmVy

c2l0eSwgVGFpcGVpLCBUYWl3YW48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgZWZm

ZWN0cyBvZiBvbWVnYS0zIGZhdHR5IGFjaWRzIG1vbm90aGVyYXB5IGluIEFsemhlaW1lciZhcG9z

O3MgZGlzZWFzZSBhbmQgbWlsZCBjb2duaXRpdmUgaW1wYWlybWVudDogYSBwcmVsaW1pbmFyeSBy

YW5kb21pemVkIGRvdWJsZS1ibGluZCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1ZHk8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+UHJvZ3Jlc3MgaW4gTmV1cm8tUHN5Y2hvcGhhcm1hY29sb2d5ICZhbXA7

IEJpb2xvZ2ljYWwgUHN5Y2hpYXRyeTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHJvZyBO

ZXVyb3BzeWNob3BoYXJtYWNvbCBCaW9sIFBzeWNoaWF0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Qcm9ncmVzcyBpbiBOZXVyby1Qc3ljaG9waGFybWFjb2xv

Z3kgJmFtcDsgQmlvbG9naWNhbCBQc3ljaGlhdHJ5PC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvZyBO

ZXVyb3BzeWNob3BoYXJtYWNvbCBCaW9sIFBzeWNoaWF0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+

PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlByb2dyZXNzIGluIE5ldXJvLVBzeWNob3BoYXJt

YWNvbG9neSAmYW1wOyBCaW9sb2dpY2FsIFBzeWNoaWF0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5Q

cm9nIE5ldXJvcHN5Y2hvcGhhcm1hY29sIEJpb2wgUHN5Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBl

cmlvZGljYWw+PHBhZ2VzPjE1MzgtMTU0NDwvcGFnZXM+PHZvbHVtZT4zMjwvdm9sdW1lPjxudW1i

ZXI+NjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlv

bj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFsemhlaW1lciBEaXNl

YXNlL2JsIFtCbG9vZF0gKkFsemhlaW1lciBEaXNlYXNlL2R0IFtEcnVnIFRoZXJhcHldIEFsemhl

aW1lciBEaXNlYXNlL3B4IFtQc3ljaG9sb2d5XSBDb2duaXRpb24gRGlzb3JkZXJzL2JsIFtCbG9v

ZF0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZHQgW0RydWcgVGhlcmFweV0gQ29nbml0aW9uIERpc29y

ZGVycy9weCBbUHN5Y2hvbG9neV0gRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvczwva2V5d29yZD48

L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MDI3OC01ODQ2

PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnBucGJwLjIwMDgu

MDUuMDE1O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24t

VS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6

Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZh

bXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODU3MzU4NWh0dHA6Ly9zZngudWNs

LmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NTczNTg1JmFt

cDtpZD1kb2k6MTAuMTAxNiUyRmoucG5wYnAuMjAwOC4wNS4wMTUmYW1wO2lzc249MDI3OC01ODQ2

JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMyJmFtcDtpc3N1ZT02JmFtcDtzcGFnZT0xNTM4JmFtcDtw

YWdlcz0xNTM4LTQ0JmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPVByb2dyZXNzK2luK05ldXJvLVBz

eWNob3BoYXJtYWNvbG9neSslMjYrQmlvbG9naWNhbCtQc3ljaGlhdHJ5JmFtcDthdGl0bGU9VGhl

K2VmZmVjdHMrb2Yrb21lZ2EtMytmYXR0eSthY2lkcyttb25vdGhlcmFweStpbitBbHpoZWltZXIl

MjdzK2Rpc2Vhc2UrYW5kK21pbGQrY29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYStwcmVsaW1pbmFy

eStyYW5kb21pemVkK2RvdWJsZS1ibGluZCtwbGFjZWJvLWNvbnRyb2xsZWQrc3R1ZHkuJmFtcDth

dWxhc3Q9Q2hpdTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgB=

ADDIN EN.CITE.DATA (15)Older adults with Alzheimer's Disease or Mild Cognitive Impairment, TaiwanEPA & DHA supplement, 1.08g/d EPA & 0.72 g/d DHALCn3 vs MUFA24 int, 22 cont0.5 yearsDART2 Burr 2003PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXJyPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj

TnVtPjIyMzc8L1JlY051bT48RGlzcGxheVRleHQ+KDUwKTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4yMjM3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAyMTA2NzQiPjIyMzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJ1

cnIsIE0uIEwuPC9hdXRob3I+PGF1dGhvcj5Bc2hmaWVsZC1XYXR0LCBQLiBBLjwvYXV0aG9yPjxh

dXRob3I+RHVuc3RhbiwgRi4gRC48L2F1dGhvcj48YXV0aG9yPkZlaGlseSwgQS4gTS48L2F1dGhv

cj48YXV0aG9yPkJyZWF5LCBQLjwvYXV0aG9yPjxhdXRob3I+QXNodG9uLCBULjwvYXV0aG9yPjxh

dXRob3I+Wm90b3MsIFAuIEMuPC9hdXRob3I+PGF1dGhvcj5IYWJvdWJpLCBOLiBBLjwvYXV0aG9y

PjxhdXRob3I+RWx3b29kLCBQLiBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkJ1cnIsTSBMLiBVbml2ZXJzaXR5IG9mIFdhbGVzIENvbGxlZ2Ugb2YgTWVk

aWNpbmUsIENhcmRpZmYsIFVLLiBtaWNoYWVsLmJ1cnJAYnJvLXRhZi1oYS53YWxlcy5uaHMudWs8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MYWNrIG9mIGJlbmVmaXQgb2YgZGlldGFyeSBh

ZHZpY2UgdG8gbWVuIHdpdGggYW5naW5hOiByZXN1bHRzIG9mIGEgY29udHJvbGxlZCB0cmlhbDwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJp

dGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+RXVyIEogQ2xpbiBOdXRyPC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBD

bGluaWNhbCBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIgSiBDbGluIE51dHI8L2Fi

YnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpv

dXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEogQ2xp

biBOdXRyPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTkzLTIwMDwvcGFnZXM+PHZv

bHVtZT41Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElO

IEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5naW5hIFBlY3Rvcmlz

L2JsIFtCbG9vZF0gKkFuZ2luYSBQZWN0b3Jpcy9kaCBbRGlldCBUaGVyYXB5XSAqQW5naW5hIFBl

Y3RvcmlzL21vIFtNb3J0YWxpdHldICpBdmVuYSAqRGlldCBFaWNvc2FwZW50YWVub2ljIEFjaWQg

RmF0dHkgQWNpZHMsVW5zYXR1cmF0ZWQvYmwgW0Jsb29kXSAqRmlzaCBPaWxzL2FkIFtBZG1pbmlz

dHJhdGlvbiAmYW1wOyBEb3NhZ2VdIEZpc2ggT2lscy9ibCBbQmxvb2RdICpGcnVpdCBIdW1hbnMg

TWFsZSBNaWRkbGUgQWc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMzwveWVh

cj48L2RhdGVzPjxpc2JuPjA5NTQtMzAwNzwvaXNibj48d29yay10eXBlPkNsaW5pY2FsIFRyaWFs

IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH

b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1tZWQ0JmFtcDtBTj0xMjU3MTY0OWh0dHA6Ly9zZngudWNsLmFjLnVr

L3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjEyNTcxNjQ5JmFtcDtpZD1k

b2k6JmFtcDtpc3NuPTA5NTQtMzAwNyZhbXA7aXNibj0mYW1wO3ZvbHVtZT01NyZhbXA7aXNzdWU9

MiZhbXA7c3BhZ2U9MTkzJmFtcDtwYWdlcz0xOTMtMjAwJmFtcDtkYXRlPTIwMDMmYW1wO3RpdGxl

PUV1cm9wZWFuK0pvdXJuYWwrb2YrQ2xpbmljYWwrTnV0cml0aW9uJmFtcDthdGl0bGU9TGFjaytv

ZitiZW5lZml0K29mK2RpZXRhcnkrYWR2aWNlK3RvK21lbit3aXRoK2FuZ2luYSUzQStyZXN1bHRz

K29mK2ErY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1CdXJyPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXJyPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVj

TnVtPjIyMzc8L1JlY051bT48RGlzcGxheVRleHQ+KDUwKTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4yMjM3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9IjE1

MzAyMTA2NzQiPjIyMzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJ1

cnIsIE0uIEwuPC9hdXRob3I+PGF1dGhvcj5Bc2hmaWVsZC1XYXR0LCBQLiBBLjwvYXV0aG9yPjxh

dXRob3I+RHVuc3RhbiwgRi4gRC48L2F1dGhvcj48YXV0aG9yPkZlaGlseSwgQS4gTS48L2F1dGhv

cj48YXV0aG9yPkJyZWF5LCBQLjwvYXV0aG9yPjxhdXRob3I+QXNodG9uLCBULjwvYXV0aG9yPjxh

dXRob3I+Wm90b3MsIFAuIEMuPC9hdXRob3I+PGF1dGhvcj5IYWJvdWJpLCBOLiBBLjwvYXV0aG9y

PjxhdXRob3I+RWx3b29kLCBQLiBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48

YXV0aC1hZGRyZXNzPkJ1cnIsTSBMLiBVbml2ZXJzaXR5IG9mIFdhbGVzIENvbGxlZ2Ugb2YgTWVk

aWNpbmUsIENhcmRpZmYsIFVLLiBtaWNoYWVsLmJ1cnJAYnJvLXRhZi1oYS53YWxlcy5uaHMudWs8

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MYWNrIG9mIGJlbmVmaXQgb2YgZGlldGFyeSBh

ZHZpY2UgdG8gbWVuIHdpdGggYW5naW5hOiByZXN1bHRzIG9mIGEgY29udHJvbGxlZCB0cmlhbDwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJp

dGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+RXVyIEogQ2xpbiBOdXRyPC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBD

bGluaWNhbCBOdXRyaXRpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIgSiBDbGluIE51dHI8L2Fi

YnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpv

dXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEogQ2xp

biBOdXRyPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTkzLTIwMDwvcGFnZXM+PHZv

bHVtZT41Nzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElO

IEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5naW5hIFBlY3Rvcmlz

L2JsIFtCbG9vZF0gKkFuZ2luYSBQZWN0b3Jpcy9kaCBbRGlldCBUaGVyYXB5XSAqQW5naW5hIFBl

Y3RvcmlzL21vIFtNb3J0YWxpdHldICpBdmVuYSAqRGlldCBFaWNvc2FwZW50YWVub2ljIEFjaWQg

RmF0dHkgQWNpZHMsVW5zYXR1cmF0ZWQvYmwgW0Jsb29kXSAqRmlzaCBPaWxzL2FkIFtBZG1pbmlz

dHJhdGlvbiAmYW1wOyBEb3NhZ2VdIEZpc2ggT2lscy9ibCBbQmxvb2RdICpGcnVpdCBIdW1hbnMg

TWFsZSBNaWRkbGUgQWc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMzwveWVh

cj48L2RhdGVzPjxpc2JuPjA5NTQtMzAwNzwvaXNibj48d29yay10eXBlPkNsaW5pY2FsIFRyaWFs

IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH

b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1tZWQ0JmFtcDtBTj0xMjU3MTY0OWh0dHA6Ly9zZngudWNsLmFjLnVr

L3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjEyNTcxNjQ5JmFtcDtpZD1k

b2k6JmFtcDtpc3NuPTA5NTQtMzAwNyZhbXA7aXNibj0mYW1wO3ZvbHVtZT01NyZhbXA7aXNzdWU9

MiZhbXA7c3BhZ2U9MTkzJmFtcDtwYWdlcz0xOTMtMjAwJmFtcDtkYXRlPTIwMDMmYW1wO3RpdGxl

PUV1cm9wZWFuK0pvdXJuYWwrb2YrQ2xpbmljYWwrTnV0cml0aW9uJmFtcDthdGl0bGU9TGFjaytv

ZitiZW5lZml0K29mK2RpZXRhcnkrYWR2aWNlK3RvK21lbit3aXRoK2FuZ2luYSUzQStyZXN1bHRz

K29mK2ErY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1CdXJyPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (50)Men treated for angina, UKDietary fish advice or EPA supplement, 2.4 g/week EPA LCn3 vs nil1571 int, 1543 cont3-9 yearsDerosa 2016 ADDIN EN.CITE <EndNote><Cite><Author>Derosa</Author><Year>2016</Year><RecNum>18382</RecNum><DisplayText>(5)</DisplayText><record><rec-number>18382</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530304135">18382</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Derosa, G.</author><author>Cicero, A. F.</author><author>D&apos;Angelo, A.</author><author>Borghi, C.</author><author>Maffioli, P.</author></authors></contributors><titles><title>Effects of n-3 PUFAs on fasting plasma glucose and insulin resistance in patients with impaired fasting glucose or impaired glucose tolerance</title><secondary-title>BioFactors</secondary-title></titles><periodical><full-title>BioFactors (Oxford, England)</full-title><abbr-1>BioFactors</abbr-1></periodical><pages>316-322</pages><volume>42</volume><number>3</number><dates><year>2016</year></dates><urls></urls></record></Cite></EndNote>(5)Overweight/obese Caucasians with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), ItalyEPA & DHA supplement, 0.83g/d EPA & 1.57 g/d DHALCn3 vs non-fat138 int, 143 cont1.5 yearsDIPP – Tokudome 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub2t1ZG9tZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

PFJlY051bT4xNjA1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTcpPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjE2MDUxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTg0MDgiPjE2MDUxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Ub2t1ZG9tZSwgUy48L2F1dGhvcj48YXV0aG9yPkt1cmlraSwgSy48L2F1dGhvcj48YXV0

aG9yPllva295YW1hLCBZLjwvYXV0aG9yPjxhdXRob3I+U2FzYWtpLCBNLjwvYXV0aG9yPjxhdXRo

b3I+Sm9oLCBULjwvYXV0aG9yPjxhdXRob3I+S2FtaXlhLCBULjwvYXV0aG9yPjxhdXRob3I+Q2hl

bmcsIEouPC9hdXRob3I+PGF1dGhvcj5PZ2F3YSwgSy48L2F1dGhvcj48YXV0aG9yPlNoaXJhaSwg

VC48L2F1dGhvcj48YXV0aG9yPkltYWVkYSwgTi48L2F1dGhvcj48YXV0aG9yPkdvdG8sIEMuPC9h

dXRob3I+PGF1dGhvcj5Ub2t1ZG9tZSwgWS48L2F1dGhvcj48YXV0aG9yPkljaGlrYXdhLCBILjwv

YXV0aG9yPjxhdXRob3I+T2t1eWFtYSwgSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5Ub2t1ZG9tZSxTaGlua2FuLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBI

ZWFsdGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwg

U2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgTmF0aW9uYWwgSW5zdGl0dXRlIG9m

IEhlYWx0aCBhbmQgTnV0cml0aW9uLCBTaGluanVrdS1rdSwgVG9reW8sIEphcGFuOyBTb2NpYWwg

V2VsZmFyZSBJbnN0aXR1dGlvbnMgU2VpemFucmkta2FpLCBCaXdhamltYSBDYXJlIENlbnRlciwg

TmlzaGkta3UsIE5hZ295YSwgSmFwYW4uIEVsZWN0cm9uaWMgYWRkcmVzczogdG9rdWRvbWUyMDEz

QGdtYWlsLmNvbS4gS3VyaWtpLEtpeW9ub3JpLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGgs

IE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5j

ZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgRGVwYXJ0bWVudCBvZiBOdXRyaXRpb24gYW5k

IEhlYWx0aCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBTaGl6dW9rYSwgU3VydWdhLWt1LCBTaGl6

dW9rYSwgSmFwYW4uIFlva295YW1hLFlvc2hpZnVtaS4gRGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRl

cm9sb2d5IGFuZCBNZXRhYm9saXNtLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNj

aG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IE5hZ295

YSBNZWRpY2FsIEFzc29jaWF0aW9uIEhlYWx0aCBDYXJlIENlbnRlciwgSGlnYXNoaS1rdSwgTmFn

b3lhLCBKYXBhbi4gU2FzYWtpLE1ha290by4gRGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRlcm9sb2d5

IGFuZCBNZXRhYm9saXNtLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBv

ZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IERlcGFydG1lbnQg

b2YgR2FzdHJvZW50ZXJvbG9neSwgQWljaGkgTWVkaWNhbCBVbml2ZXJzaXR5LCBOYWdha3V0ZSwg

SmFwYW4uIEpvaCxUYWthc2hpLiBEZXBhcnRtZW50IG9mIEdhc3Ryb2VudGVyb2xvZ3kgYW5kIE1l

dGFib2xpc20sIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGlj

YWwgU2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gS2FtaXlhLFRha2VzaGkuIERl

cGFydG1lbnQgb2YgR2FzdHJvZW50ZXJvbG9neSBhbmQgTWV0YWJvbGlzbSwgTmFnb3lhIENpdHkg

VW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBTY2llbmNlcywgTWl6dWhvLWt1

LCBOYWdveWEsIEphcGFuLiBDaGVuZyxKaW5nbGVpLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFs

dGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2Np

ZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gT2dhd2EsS3VtaWtvLiBEZXBhcnRtZW50

IG9mIEV4cGVyaW1lbnRhbCBQYXRob2xvZ3kgYW5kIFR1bW9yIEJpb2xvZ3ksIE5hZ295YSBDaXR5

IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5jZXMsIE1penVoby1r

dSwgTmFnb3lhLCBKYXBhbjsgRGl2aXNpb24gb2YgUGF0aG9sb2d5LCBOYXRpb25hbCBJbnN0aXR1

dGUgb2YgSGVhbHRoIFNjaWVuY2VzLCBTZXRhZ2F5YS1rdSwgVG9reW8sIEphcGFuLiBTaGlyYWks

VG9tb3l1a2kuIERlcGFydG1lbnQgb2YgRXhwZXJpbWVudGFsIFBhdGhvbG9neSBhbmQgVHVtb3Ig

QmlvbG9neSwgTmFnb3lhIENpdHkgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNh

bCBTY2llbmNlcywgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuOyBOYWdveWEgQ2l0eSBSZWhhYmls

aXRhdGlvbiBDZW50ZXIsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gSW1hZWRhLE5haG9taS4g

RGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1

YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47

IERlcGFydG1lbnQgb2YgRm9vZCBTY2llbmNlIGFuZCBOdXRyaXRpb24sIE5hZ295YSBXb21lbiZh

cG9zO3MgVW5pdmVyc2l0eSwgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuLiBHb3RvLENoaWhvLiBE

ZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVh

dGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsg

RGVwYXJ0bWVudCBvZiBIZWFsdGggYW5kIE51dHJpdGlvbiwgTmFnb3lhIEJ1bnJpIFVuaXZlcnNp

dHksIEluYXphd2EsIEphcGFuLiBUb2t1ZG9tZSxZdWtvLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBI

ZWFsdGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwg

U2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgU2Nob29sIG9mIE51dHJpdGlvbmFs

IFNjaWVuY2VzLCBOYWdveWEgVW5pdmVyc2l0eSBvZiBBcnRzIGFuZCBTY2llbmNlcywgTmlzc2hp

biwgSmFwYW4uIEljaGlrYXdhLEhpcm9taXRzdS4gRGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRo

LCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVu

Y2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW4uIE9rdXlhbWEsSGFydW1pLiBJbnN0aXR1dGUg

Zm9yIENvbnN1bWVyIFNjaWVuY2UgYW5kIEh1bWFuIExpZmUsIEtpbmpvIEdha3VpbiBVbml2ZXJz

aXR5LCBNb3JpeWFtYS1rdSwgTmFnb3lhLCBKYXBhbjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkRpZXRhcnkgbi0zL2xvbmctY2hhaW4gbi0zIHBvbHl1bnNhdHVyYXRlZCBmYXR0eSBhY2lk

cyBmb3IgcHJldmVudGlvbiBvZiBzcG9yYWRpYyBjb2xvcmVjdGFsIHR1bW9yczogYSByYW5kb21p

emVkIGNvbnRyb2xsZWQgdHJpYWwgaW4gcG9seXBlY3RvbWl6ZWQgcGFydGljaXBhbnRzPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPlByb3N0YWdsYW5kaW5zIExldWtvdHJpZW5lcyAmYW1wOyBFc3Nl

bnRpYWwgRmF0dHkgQWNpZHM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlByb3N0YWdsYW5k

aW5zIExldWtvdCBFc3NlbnQgRmF0dHkgQWNpZHM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Qcm9zdGFnbGFuZGlucyBMZXVrb3RyaWVuZXMgJmFtcDsgRXNzZW50

aWFsIEZhdHR5IEFjaWRzPC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvc3RhZ2xhbmRpbnMgTGV1a290

IEVzc2VudCBGYXR0eSBBY2lkczwvYWJici0xPjxhYmJyLTI+UHJvc2FnbGFuZGlucyBMZXVrb3Ry

aWVuZXMgYW5kIEVzc2VudGlhbCBGYXR0eSBBY2lkczwvYWJici0yPjxhYmJyLTM+UHJvc3RhZ2xh

bmRpbnMsIExldWtvdHJpZW5lcyBhbmQgRXNzZW50aWFsIEZhdHR5IEFjaWRzPC9hYmJyLTM+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Qcm9zdGFnbGFuZGlucyBMZXVr

b3RyaWVuZXMgJmFtcDsgRXNzZW50aWFsIEZhdHR5IEFjaWRzPC9mdWxsLXRpdGxlPjxhYmJyLTE+

UHJvc3RhZ2xhbmRpbnMgTGV1a290IEVzc2VudCBGYXR0eSBBY2lkczwvYWJici0xPjxhYmJyLTI+

UHJvc2FnbGFuZGlucyBMZXVrb3RyaWVuZXMgYW5kIEVzc2VudGlhbCBGYXR0eSBBY2lkczwvYWJi

ci0yPjxhYmJyLTM+UHJvc3RhZ2xhbmRpbnMsIExldWtvdHJpZW5lcyBhbmQgRXNzZW50aWFsIEZh

dHR5IEFjaWRzPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MS0xMTwvcGFnZXM+PHZv

bHVtZT45NDwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIENhc2UtQ29udHJv

bCBTdHVkaWVzIENvbG9yZWN0YWwgTmVvcGxhc21zL2JsIFtCbG9vZF0gKkNvbG9yZWN0YWwgTmVv

cGxhc21zL2R0IFtEcnVnIFRoZXJhcHldICpDb2xvcmVjdGFsIE5lb3BsYXNtcy9wYyBbUHJldmVu

dGlvbiAmYW1wOyBDb250cm9sXSBDb2xvcmVjdGFsIE5lb3BsYXNtcy9zdSBbU3VyZ2VyeV0gKkRp

ZXRhcnkgRmF0cyxVbnNhdHVyYXRlZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBE

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTMyLTI4MjM8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ou

cGxlZmEuMjAxNC4wOS4wMDE7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1

cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxz

Pjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZh

bXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI1NDUxNTU2aHR0

cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6

MjU0NTE1NTYmYW1wO2lkPWRvaToxMC4xMDE2JTJGai5wbGVmYS4yMDE0LjA5LjAwMSZhbXA7aXNz

bj0wOTUyLTMyNzgmYW1wO2lzYm49JmFtcDt2b2x1bWU9OTQmYW1wO2lzc3VlPSZhbXA7c3BhZ2U9

MSZhbXA7cGFnZXM9MS0xMSZhbXA7ZGF0ZT0yMDE1JmFtcDt0aXRsZT1Qcm9zdGFnbGFuZGlucytM

ZXVrb3RyaWVuZXMrJTI2K0Vzc2VudGlhbCtGYXR0eStBY2lkcyZhbXA7YXRpdGxlPURpZXRhcnkr

bi0zJTJGbG9uZy1jaGFpbituLTMrcG9seXVuc2F0dXJhdGVkK2ZhdHR5K2FjaWRzK2ZvcitwcmV2

ZW50aW9uK29mK3Nwb3JhZGljK2NvbG9yZWN0YWwrdHVtb3JzJTNBK2ErcmFuZG9taXplZCtjb250

cm9sbGVkK3RyaWFsK2luK3BvbHlwZWN0b21pemVkK3BhcnRpY2lwYW50cy4mYW1wO2F1bGFzdD1U

b2t1ZG9tZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub2t1ZG9tZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

PFJlY051bT4xNjA1MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTcpPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjE2MDUxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTg0MDgiPjE2MDUxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Ub2t1ZG9tZSwgUy48L2F1dGhvcj48YXV0aG9yPkt1cmlraSwgSy48L2F1dGhvcj48YXV0

aG9yPllva295YW1hLCBZLjwvYXV0aG9yPjxhdXRob3I+U2FzYWtpLCBNLjwvYXV0aG9yPjxhdXRo

b3I+Sm9oLCBULjwvYXV0aG9yPjxhdXRob3I+S2FtaXlhLCBULjwvYXV0aG9yPjxhdXRob3I+Q2hl

bmcsIEouPC9hdXRob3I+PGF1dGhvcj5PZ2F3YSwgSy48L2F1dGhvcj48YXV0aG9yPlNoaXJhaSwg

VC48L2F1dGhvcj48YXV0aG9yPkltYWVkYSwgTi48L2F1dGhvcj48YXV0aG9yPkdvdG8sIEMuPC9h

dXRob3I+PGF1dGhvcj5Ub2t1ZG9tZSwgWS48L2F1dGhvcj48YXV0aG9yPkljaGlrYXdhLCBILjwv

YXV0aG9yPjxhdXRob3I+T2t1eWFtYSwgSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv

cnM+PGF1dGgtYWRkcmVzcz5Ub2t1ZG9tZSxTaGlua2FuLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBI

ZWFsdGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwg

U2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgTmF0aW9uYWwgSW5zdGl0dXRlIG9m

IEhlYWx0aCBhbmQgTnV0cml0aW9uLCBTaGluanVrdS1rdSwgVG9reW8sIEphcGFuOyBTb2NpYWwg

V2VsZmFyZSBJbnN0aXR1dGlvbnMgU2VpemFucmkta2FpLCBCaXdhamltYSBDYXJlIENlbnRlciwg

TmlzaGkta3UsIE5hZ295YSwgSmFwYW4uIEVsZWN0cm9uaWMgYWRkcmVzczogdG9rdWRvbWUyMDEz

QGdtYWlsLmNvbS4gS3VyaWtpLEtpeW9ub3JpLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGgs

IE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5j

ZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgRGVwYXJ0bWVudCBvZiBOdXRyaXRpb24gYW5k

IEhlYWx0aCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBTaGl6dW9rYSwgU3VydWdhLWt1LCBTaGl6

dW9rYSwgSmFwYW4uIFlva295YW1hLFlvc2hpZnVtaS4gRGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRl

cm9sb2d5IGFuZCBNZXRhYm9saXNtLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNj

aG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IE5hZ295

YSBNZWRpY2FsIEFzc29jaWF0aW9uIEhlYWx0aCBDYXJlIENlbnRlciwgSGlnYXNoaS1rdSwgTmFn

b3lhLCBKYXBhbi4gU2FzYWtpLE1ha290by4gRGVwYXJ0bWVudCBvZiBHYXN0cm9lbnRlcm9sb2d5

IGFuZCBNZXRhYm9saXNtLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBv

ZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47IERlcGFydG1lbnQg

b2YgR2FzdHJvZW50ZXJvbG9neSwgQWljaGkgTWVkaWNhbCBVbml2ZXJzaXR5LCBOYWdha3V0ZSwg

SmFwYW4uIEpvaCxUYWthc2hpLiBEZXBhcnRtZW50IG9mIEdhc3Ryb2VudGVyb2xvZ3kgYW5kIE1l

dGFib2xpc20sIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGlj

YWwgU2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gS2FtaXlhLFRha2VzaGkuIERl

cGFydG1lbnQgb2YgR2FzdHJvZW50ZXJvbG9neSBhbmQgTWV0YWJvbGlzbSwgTmFnb3lhIENpdHkg

VW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBTY2llbmNlcywgTWl6dWhvLWt1

LCBOYWdveWEsIEphcGFuLiBDaGVuZyxKaW5nbGVpLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFs

dGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2Np

ZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gT2dhd2EsS3VtaWtvLiBEZXBhcnRtZW50

IG9mIEV4cGVyaW1lbnRhbCBQYXRob2xvZ3kgYW5kIFR1bW9yIEJpb2xvZ3ksIE5hZ295YSBDaXR5

IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5jZXMsIE1penVoby1r

dSwgTmFnb3lhLCBKYXBhbjsgRGl2aXNpb24gb2YgUGF0aG9sb2d5LCBOYXRpb25hbCBJbnN0aXR1

dGUgb2YgSGVhbHRoIFNjaWVuY2VzLCBTZXRhZ2F5YS1rdSwgVG9reW8sIEphcGFuLiBTaGlyYWks

VG9tb3l1a2kuIERlcGFydG1lbnQgb2YgRXhwZXJpbWVudGFsIFBhdGhvbG9neSBhbmQgVHVtb3Ig

QmlvbG9neSwgTmFnb3lhIENpdHkgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNh

bCBTY2llbmNlcywgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuOyBOYWdveWEgQ2l0eSBSZWhhYmls

aXRhdGlvbiBDZW50ZXIsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbi4gSW1hZWRhLE5haG9taS4g

RGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRoLCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1

YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW47

IERlcGFydG1lbnQgb2YgRm9vZCBTY2llbmNlIGFuZCBOdXRyaXRpb24sIE5hZ295YSBXb21lbiZh

cG9zO3MgVW5pdmVyc2l0eSwgTWl6dWhvLWt1LCBOYWdveWEsIEphcGFuLiBHb3RvLENoaWhvLiBE

ZXBhcnRtZW50IG9mIFB1YmxpYyBIZWFsdGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVh

dGUgU2Nob29sIG9mIE1lZGljYWwgU2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsg

RGVwYXJ0bWVudCBvZiBIZWFsdGggYW5kIE51dHJpdGlvbiwgTmFnb3lhIEJ1bnJpIFVuaXZlcnNp

dHksIEluYXphd2EsIEphcGFuLiBUb2t1ZG9tZSxZdWtvLiBEZXBhcnRtZW50IG9mIFB1YmxpYyBI

ZWFsdGgsIE5hZ295YSBDaXR5IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwg

U2NpZW5jZXMsIE1penVoby1rdSwgTmFnb3lhLCBKYXBhbjsgU2Nob29sIG9mIE51dHJpdGlvbmFs

IFNjaWVuY2VzLCBOYWdveWEgVW5pdmVyc2l0eSBvZiBBcnRzIGFuZCBTY2llbmNlcywgTmlzc2hp

biwgSmFwYW4uIEljaGlrYXdhLEhpcm9taXRzdS4gRGVwYXJ0bWVudCBvZiBQdWJsaWMgSGVhbHRo

LCBOYWdveWEgQ2l0eSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIFNjaWVu

Y2VzLCBNaXp1aG8ta3UsIE5hZ295YSwgSmFwYW4uIE9rdXlhbWEsSGFydW1pLiBJbnN0aXR1dGUg

Zm9yIENvbnN1bWVyIFNjaWVuY2UgYW5kIEh1bWFuIExpZmUsIEtpbmpvIEdha3VpbiBVbml2ZXJz

aXR5LCBNb3JpeWFtYS1rdSwgTmFnb3lhLCBKYXBhbjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkRpZXRhcnkgbi0zL2xvbmctY2hhaW4gbi0zIHBvbHl1bnNhdHVyYXRlZCBmYXR0eSBhY2lk

cyBmb3IgcHJldmVudGlvbiBvZiBzcG9yYWRpYyBjb2xvcmVjdGFsIHR1bW9yczogYSByYW5kb21p

emVkIGNvbnRyb2xsZWQgdHJpYWwgaW4gcG9seXBlY3RvbWl6ZWQgcGFydGljaXBhbnRzPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPlByb3N0YWdsYW5kaW5zIExldWtvdHJpZW5lcyAmYW1wOyBFc3Nl

bnRpYWwgRmF0dHkgQWNpZHM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlByb3N0YWdsYW5k

aW5zIExldWtvdCBFc3NlbnQgRmF0dHkgQWNpZHM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5Qcm9zdGFnbGFuZGlucyBMZXVrb3RyaWVuZXMgJmFtcDsgRXNzZW50

aWFsIEZhdHR5IEFjaWRzPC9mdWxsLXRpdGxlPjxhYmJyLTE+UHJvc3RhZ2xhbmRpbnMgTGV1a290

IEVzc2VudCBGYXR0eSBBY2lkczwvYWJici0xPjxhYmJyLTI+UHJvc2FnbGFuZGlucyBMZXVrb3Ry

aWVuZXMgYW5kIEVzc2VudGlhbCBGYXR0eSBBY2lkczwvYWJici0yPjxhYmJyLTM+UHJvc3RhZ2xh

bmRpbnMsIExldWtvdHJpZW5lcyBhbmQgRXNzZW50aWFsIEZhdHR5IEFjaWRzPC9hYmJyLTM+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Qcm9zdGFnbGFuZGlucyBMZXVr

b3RyaWVuZXMgJmFtcDsgRXNzZW50aWFsIEZhdHR5IEFjaWRzPC9mdWxsLXRpdGxlPjxhYmJyLTE+

UHJvc3RhZ2xhbmRpbnMgTGV1a290IEVzc2VudCBGYXR0eSBBY2lkczwvYWJici0xPjxhYmJyLTI+

UHJvc2FnbGFuZGlucyBMZXVrb3RyaWVuZXMgYW5kIEVzc2VudGlhbCBGYXR0eSBBY2lkczwvYWJi

ci0yPjxhYmJyLTM+UHJvc3RhZ2xhbmRpbnMsIExldWtvdHJpZW5lcyBhbmQgRXNzZW50aWFsIEZh

dHR5IEFjaWRzPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MS0xMTwvcGFnZXM+PHZv

bHVtZT45NDwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIENhc2UtQ29udHJv

bCBTdHVkaWVzIENvbG9yZWN0YWwgTmVvcGxhc21zL2JsIFtCbG9vZF0gKkNvbG9yZWN0YWwgTmVv

cGxhc21zL2R0IFtEcnVnIFRoZXJhcHldICpDb2xvcmVjdGFsIE5lb3BsYXNtcy9wYyBbUHJldmVu

dGlvbiAmYW1wOyBDb250cm9sXSBDb2xvcmVjdGFsIE5lb3BsYXNtcy9zdSBbU3VyZ2VyeV0gKkRp

ZXRhcnkgRmF0cyxVbnNhdHVyYXRlZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBE

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48aXNi

bj4xNTMyLTI4MjM8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ou

cGxlZmEuMjAxNC4wOS4wMDE7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1

cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxz

Pjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZh

bXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI1NDUxNTU2aHR0

cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6

MjU0NTE1NTYmYW1wO2lkPWRvaToxMC4xMDE2JTJGai5wbGVmYS4yMDE0LjA5LjAwMSZhbXA7aXNz

bj0wOTUyLTMyNzgmYW1wO2lzYm49JmFtcDt2b2x1bWU9OTQmYW1wO2lzc3VlPSZhbXA7c3BhZ2U9

MSZhbXA7cGFnZXM9MS0xMSZhbXA7ZGF0ZT0yMDE1JmFtcDt0aXRsZT1Qcm9zdGFnbGFuZGlucytM

ZXVrb3RyaWVuZXMrJTI2K0Vzc2VudGlhbCtGYXR0eStBY2lkcyZhbXA7YXRpdGxlPURpZXRhcnkr

bi0zJTJGbG9uZy1jaGFpbituLTMrcG9seXVuc2F0dXJhdGVkK2ZhdHR5K2FjaWRzK2ZvcitwcmV2

ZW50aW9uK29mK3Nwb3JhZGljK2NvbG9yZWN0YWwrdHVtb3JzJTNBK2ErcmFuZG9taXplZCtjb250

cm9sbGVkK3RyaWFsK2luK3BvbHlwZWN0b21pemVkK3BhcnRpY2lwYW50cy4mYW1wO2F1bGFzdD1U

b2t1ZG9tZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPgB=

ADDIN EN.CITE.DATA (17)Patients previously polypectomised for colorectal tumours, JapanDietary advice to increase oily fish & ALA-rich oil & EPA & DHA supplement, unclear EPA & DHALCn3 vs non-fat104 int, 101 cont2 yearsDO IT - Einvik 2010PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FaW52aWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+NDM5MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTgpPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQzOTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDIxMTgyMyI+NDM5Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

RWludmlrLCBHLjwvYXV0aG9yPjxhdXRob3I+RWtlYmVyZywgTy48L2F1dGhvcj48YXV0aG9yPkxh

dmlrLCBKLiBHLjwvYXV0aG9yPjxhdXRob3I+RWxsaW5nc2VuLCBJLjwvYXV0aG9yPjxhdXRob3I+

S2xlbXNkYWwsIFQuIE8uPC9hdXRob3I+PGF1dGhvcj5IamVya2lubiwgRS4gTS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5FaW52aWssR3VubmFyLiBEaXZp

c2lvbiBvZiBNZWRpY2luZSwgQWtlcnNodXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgTG9yZW5za29n

LCBOb3J3YXk7IERlcGFydG1lbnQgb2YgQmVoYXZpb3VyYWwgU2NpZW5jZSwgVW5pdmVyc2l0eSBv

ZiBPc2xvLCBPc2xvLCBOb3J3YXkuIGd1bm5hci5laW52aWtAbWVkaXNpbi51aW8ubm88L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgaW5mbHVlbmNlIG9mIGxvbmctdGVybSBhd2FyZW5l

c3Mgb2YgaHlwZXJsaXBpZGVtaWEgYW5kIG9mIDMgeWVhcnMgb2YgZGlldGFyeSBjb3Vuc2VsaW5n

IG9uIGRlcHJlc3Npb24sIGFueGlldHksIGFuZCBxdWFsaXR5IG9mIGxpZmU8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Sm91cm5hbCBvZiBQc3ljaG9zb21hdGljIFJlc2VhcmNoPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5KIFBzeWNob3NvbSBSZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNob3NvbWF0aWMgUmVzZWFyY2g8L2Z1

bGwtdGl0bGU+PGFiYnItMT5KIFBzeWNob3NvbSBSZXM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgUHN5Y2hvc29tYXRpYyBSZXNlYXJj

aDwvZnVsbC10aXRsZT48YWJici0xPkogUHN5Y2hvc29tIFJlczwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjU2Ny01NzI8L3BhZ2VzPjx2b2x1bWU+Njg8L3ZvbHVtZT48bnVtYmVyPjY8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkdWx0ICpBbnhpZXR5IERpc29yZGVycy9kaSBbRGlhZ25vc2lzXSBB

bnhpZXR5IERpc29yZGVycy9weCBbUHN5Y2hvbG9neV0gQXRoZXJvc2NsZXJvc2lzL2RoIFtEaWV0

IFRoZXJhcHldIEF0aGVyb3NjbGVyb3Npcy9weCBbUHN5Y2hvbG9neV0gQXR0aXR1ZGUgdG8gSGVh

bHRoICpBd2FyZW5lc3MgKkRlcHJlc3NpdmUgRGlzb3JkZXIvZGkgW0RpYWdub3Npc10gRGVwcmVz

c2l2ZSBEaXNvcmRlci9weCBbUHN5Y2hvbG9neV0gRGlldCxGYXQtUmU8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE4NzktMTM2MDwvaXNi

bj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qcHN5Y2hvcmVzLjIwMDku

MTEuMDA0O0NvbXBhcmF0aXZlIFN0dWR5IE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29u

dHJvbGxlZCBUcmlhbDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8v

b3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1w

O1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA0ODgyNzRodHRwOi8vc2Z4LnVjbC5h

Yy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMDQ4ODI3NCZhbXA7

aWQ9ZG9pOjEwLjEwMTYlMkZqLmpwc3ljaG9yZXMuMjAwOS4xMS4wMDQmYW1wO2lzc249MDAyMi0z

OTk5JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTY4JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT01NjcmYW1w

O3BhZ2VzPTU2Ny03MiZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1Kb3VybmFsK29mK1BzeWNob3Nv

bWF0aWMrUmVzZWFyY2gmYW1wO2F0aXRsZT1UaGUraW5mbHVlbmNlK29mK2xvbmctdGVybSthd2Fy

ZW5lc3Mrb2YraHlwZXJsaXBpZGVtaWErYW5kK29mKzMreWVhcnMrb2YrZGlldGFyeStjb3Vuc2Vs

aW5nK29uK2RlcHJlc3Npb24lMkMrYW54aWV0eSUyQythbmQrcXVhbGl0eStvZitsaWZlLiZhbXA7

YXVsYXN0PUVpbnZpazwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FaW52aWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+NDM5MzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTgpPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQzOTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDIxMTgyMyI+NDM5Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

RWludmlrLCBHLjwvYXV0aG9yPjxhdXRob3I+RWtlYmVyZywgTy48L2F1dGhvcj48YXV0aG9yPkxh

dmlrLCBKLiBHLjwvYXV0aG9yPjxhdXRob3I+RWxsaW5nc2VuLCBJLjwvYXV0aG9yPjxhdXRob3I+

S2xlbXNkYWwsIFQuIE8uPC9hdXRob3I+PGF1dGhvcj5IamVya2lubiwgRS4gTS48L2F1dGhvcj48

L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5FaW52aWssR3VubmFyLiBEaXZp

c2lvbiBvZiBNZWRpY2luZSwgQWtlcnNodXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgTG9yZW5za29n

LCBOb3J3YXk7IERlcGFydG1lbnQgb2YgQmVoYXZpb3VyYWwgU2NpZW5jZSwgVW5pdmVyc2l0eSBv

ZiBPc2xvLCBPc2xvLCBOb3J3YXkuIGd1bm5hci5laW52aWtAbWVkaXNpbi51aW8ubm88L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgaW5mbHVlbmNlIG9mIGxvbmctdGVybSBhd2FyZW5l

c3Mgb2YgaHlwZXJsaXBpZGVtaWEgYW5kIG9mIDMgeWVhcnMgb2YgZGlldGFyeSBjb3Vuc2VsaW5n

IG9uIGRlcHJlc3Npb24sIGFueGlldHksIGFuZCBxdWFsaXR5IG9mIGxpZmU8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Sm91cm5hbCBvZiBQc3ljaG9zb21hdGljIFJlc2VhcmNoPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5KIFBzeWNob3NvbSBSZXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBzeWNob3NvbWF0aWMgUmVzZWFyY2g8L2Z1

bGwtdGl0bGU+PGFiYnItMT5KIFBzeWNob3NvbSBSZXM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFs

dC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgUHN5Y2hvc29tYXRpYyBSZXNlYXJj

aDwvZnVsbC10aXRsZT48YWJici0xPkogUHN5Y2hvc29tIFJlczwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjU2Ny01NzI8L3BhZ2VzPjx2b2x1bWU+Njg8L3ZvbHVtZT48bnVtYmVyPjY8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkdWx0ICpBbnhpZXR5IERpc29yZGVycy9kaSBbRGlhZ25vc2lzXSBB

bnhpZXR5IERpc29yZGVycy9weCBbUHN5Y2hvbG9neV0gQXRoZXJvc2NsZXJvc2lzL2RoIFtEaWV0

IFRoZXJhcHldIEF0aGVyb3NjbGVyb3Npcy9weCBbUHN5Y2hvbG9neV0gQXR0aXR1ZGUgdG8gSGVh

bHRoICpBd2FyZW5lc3MgKkRlcHJlc3NpdmUgRGlzb3JkZXIvZGkgW0RpYWdub3Npc10gRGVwcmVz

c2l2ZSBEaXNvcmRlci9weCBbUHN5Y2hvbG9neV0gRGlldCxGYXQtUmU8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE4NzktMTM2MDwvaXNi

bj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5qcHN5Y2hvcmVzLjIwMDku

MTEuMDA0O0NvbXBhcmF0aXZlIFN0dWR5IE11bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29u

dHJvbGxlZCBUcmlhbDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8v

b3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1w

O1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MjA0ODgyNzRodHRwOi8vc2Z4LnVjbC5h

Yy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMDQ4ODI3NCZhbXA7

aWQ9ZG9pOjEwLjEwMTYlMkZqLmpwc3ljaG9yZXMuMjAwOS4xMS4wMDQmYW1wO2lzc249MDAyMi0z

OTk5JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTY4JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT01NjcmYW1w

O3BhZ2VzPTU2Ny03MiZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1Kb3VybmFsK29mK1BzeWNob3Nv

bWF0aWMrUmVzZWFyY2gmYW1wO2F0aXRsZT1UaGUraW5mbHVlbmNlK29mK2xvbmctdGVybSthd2Fy

ZW5lc3Mrb2YraHlwZXJsaXBpZGVtaWErYW5kK29mKzMreWVhcnMrb2YrZGlldGFyeStjb3Vuc2Vs

aW5nK29uK2RlcHJlc3Npb24lMkMrYW54aWV0eSUyQythbmQrcXVhbGl0eStvZitsaWZlLiZhbXA7

YXVsYXN0PUVpbnZpazwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (18)Elderly men with long standing dyslipidaemia or hypertension, NorwayEPA & DHA supplement, 0.84 g/d EPA & 0.48 g/d DHALCn3 vs n6282 int, 281 cont3 yearsEPE-A – Sanyal 2014PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW55YWw8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

ZWNOdW0+MTQxMzU8L1JlY051bT48RGlzcGxheVRleHQ+KDE5KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNDEzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE3MzI0Ij4xNDEzNTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+U2FueWFsLCBBLiBKLjwvYXV0aG9yPjxhdXRob3I+QWJkZWxtYWxlaywgTS4gRi48L2F1dGhv

cj48YXV0aG9yPlN1enVraSwgQS48L2F1dGhvcj48YXV0aG9yPkN1bW1pbmdzLCBPLiBXLjwvYXV0

aG9yPjxhdXRob3I+Q2hvamtpZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgRXBlPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2FueWFsLEFydW4gSi4g

RGl2aXNpb24gb2YgR2FzdHJvZW50ZXJvbG9neSwgSGVwYXRvbG9neSBhbmQgTnV0cml0aW9uLCBE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBWaXJnaW5pYSBDb21tb253ZWFsdGggVW5p

dmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIFJpY2htb25kLCBWaXJnaW5pYS4gRWxlY3Ryb25p

YyBhZGRyZXNzOiBhc2FueWFsQG1jdmgtdmN1LmVkdS4gQWJkZWxtYWxlayxNYW5hbCBGLiBEaXZp

c2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5IGFuZCBIZXBhdG9sb2d5LCBEdWtlIFVuaXZlcnNpdHks

IER1cmhhbSwgTm9ydGggQ2Fyb2xpbmEuIFN1enVraSxBeWFrby4gRGl2aXNpb24gb2YgR2FzdHJv

ZW50ZXJvbG9neSwgVW5pdmVyc2l0eSBvZiBBcmthbnNhcyBmb3IgTWVkaWNhbCBTY2llbmNlcywg

TGl0dGxlIFJvY2ssIEFya2Fuc2FzOyBEaXZpc2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5LCBDZW50

cmFsIEFya2Fuc2FzIFZldGVyYW5zIEhlYWx0aGNhcmUgU3lzdGVtLCBMaXR0bGUgUm9jaywgQXJr

YW5zYXMuIEN1bW1pbmdzLE9zY2FyIFcuIERlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBJbmRpYW5h

IFVuaXZlcnNpdHksIEJsb29taW5ndG9uLCBJbmRpYW5hLiBDaG9qa2llcixNYXJpby4gRGl2aXNp

b24gb2YgR2FzdHJvZW50ZXJvbG9neSBhbmQgSGVwYXRvbG9neSwgRGVwYXJ0bWVudCBvZiBJbnRl

cm5hbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlhLCBTYW4gRGllZ28sIFNhbiBE

aWVnbywgQ2FsaWZvcm5pYTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vIHNpZ25pZmlj

YW50IGVmZmVjdHMgb2YgZXRoeWwtZWljb3NhcGVudGFub2ljIGFjaWQgb24gaGlzdG9sb2dpYyBm

ZWF0dXJlcyBvZiBub25hbGNvaG9saWMgc3RlYXRvaGVwYXRpdGlzIGluIGEgcGhhc2UgMiB0cmlh

bDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5HYXN0cm9lbnRlcm9sb2d5PC9zZWNvbmRhcnktdGl0

bGU+PGFsdC10aXRsZT5HYXN0cm9lbnRlcm9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+R2FzdHJvZW50ZXJvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkdhc3Ryb2VudGVyb2xvZ3k8L2Z1bGwtdGl0

bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+Mzc3LTM4NDwvcGFnZXM+PHZvbHVtZT4xNDc8L3Zv

bHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkJpb3BzeSBEaXNlYXNlIFByb2dyZXNzaW9u

IERvdWJsZS1CbGluZCBNZXRob2QgRWljb3NhcGVudGFlbm9pYyBBY2lkL2FlIFtBZHZlcnNlIEVm

ZmVjdHNdICpFaWNvc2FwZW50YWVub2ljIEFjaWQvYWEgW0FuYWxvZ3MgJmFtcDsgRGVyaXZhdGl2

ZXNdIEVpY29zYXBlbnRhZW5vaWMgQWNpZC90dSBbVGhlcmFwZXV0aWMgVXNlXSBGYXR0eSBMaXZl

ci9jbyBbQ29tcGxpY2F0aW9uc10gKkZhdHR5IExpdmVyL2R0IFtEcnVnIFRoZXJhcHldIEZhdHR5

IExpPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48

aXNibj4xNTI4LTAwMTI8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDUz

L2ouZ2FzdHJvLjIwMTQuMDQuMDQ2O0NsaW5pY2FsIFRyaWFsLCBQaGFzZSBJSSBNdWx0aWNlbnRl

ciBTdHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9u

LVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4m

YW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjQ4MTg3NjRodHRwOi8vc2Z4LnVj

bC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyNDgxODc2NCZh

bXA7aWQ9ZG9pOjEwLjEwNTMlMkZqLmdhc3Ryby4yMDE0LjA0LjA0NiZhbXA7aXNzbj0wMDE2LTUw

ODUmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTQ3JmFtcDtpc3N1ZT0yJmFtcDtzcGFnZT0zNzcmYW1w

O3BhZ2VzPTM3Ny04NC5lMSZhbXA7ZGF0ZT0yMDE0JmFtcDt0aXRsZT1HYXN0cm9lbnRlcm9sb2d5

JmFtcDthdGl0bGU9Tm8rc2lnbmlmaWNhbnQrZWZmZWN0cytvZitldGh5bC1laWNvc2FwZW50YW5v

aWMrYWNpZCtvbitoaXN0b2xvZ2ljK2ZlYXR1cmVzK29mK25vbmFsY29ob2xpYytzdGVhdG9oZXBh

dGl0aXMraW4rYStwaGFzZSsyK3RyaWFsLiZhbXA7YXVsYXN0PVNhbnlhbDwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW55YWw8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

ZWNOdW0+MTQxMzU8L1JlY051bT48RGlzcGxheVRleHQ+KDE5KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNDEzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE3MzI0Ij4xNDEzNTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+U2FueWFsLCBBLiBKLjwvYXV0aG9yPjxhdXRob3I+QWJkZWxtYWxlaywgTS4gRi48L2F1dGhv

cj48YXV0aG9yPlN1enVraSwgQS48L2F1dGhvcj48YXV0aG9yPkN1bW1pbmdzLCBPLiBXLjwvYXV0

aG9yPjxhdXRob3I+Q2hvamtpZXIsIE0uPC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgRXBlPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2FueWFsLEFydW4gSi4g

RGl2aXNpb24gb2YgR2FzdHJvZW50ZXJvbG9neSwgSGVwYXRvbG9neSBhbmQgTnV0cml0aW9uLCBE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBWaXJnaW5pYSBDb21tb253ZWFsdGggVW5p

dmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIFJpY2htb25kLCBWaXJnaW5pYS4gRWxlY3Ryb25p

YyBhZGRyZXNzOiBhc2FueWFsQG1jdmgtdmN1LmVkdS4gQWJkZWxtYWxlayxNYW5hbCBGLiBEaXZp

c2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5IGFuZCBIZXBhdG9sb2d5LCBEdWtlIFVuaXZlcnNpdHks

IER1cmhhbSwgTm9ydGggQ2Fyb2xpbmEuIFN1enVraSxBeWFrby4gRGl2aXNpb24gb2YgR2FzdHJv

ZW50ZXJvbG9neSwgVW5pdmVyc2l0eSBvZiBBcmthbnNhcyBmb3IgTWVkaWNhbCBTY2llbmNlcywg

TGl0dGxlIFJvY2ssIEFya2Fuc2FzOyBEaXZpc2lvbiBvZiBHYXN0cm9lbnRlcm9sb2d5LCBDZW50

cmFsIEFya2Fuc2FzIFZldGVyYW5zIEhlYWx0aGNhcmUgU3lzdGVtLCBMaXR0bGUgUm9jaywgQXJr

YW5zYXMuIEN1bW1pbmdzLE9zY2FyIFcuIERlcGFydG1lbnQgb2YgUGF0aG9sb2d5LCBJbmRpYW5h

IFVuaXZlcnNpdHksIEJsb29taW5ndG9uLCBJbmRpYW5hLiBDaG9qa2llcixNYXJpby4gRGl2aXNp

b24gb2YgR2FzdHJvZW50ZXJvbG9neSBhbmQgSGVwYXRvbG9neSwgRGVwYXJ0bWVudCBvZiBJbnRl

cm5hbCBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBDYWxpZm9ybmlhLCBTYW4gRGllZ28sIFNhbiBE

aWVnbywgQ2FsaWZvcm5pYTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vIHNpZ25pZmlj

YW50IGVmZmVjdHMgb2YgZXRoeWwtZWljb3NhcGVudGFub2ljIGFjaWQgb24gaGlzdG9sb2dpYyBm

ZWF0dXJlcyBvZiBub25hbGNvaG9saWMgc3RlYXRvaGVwYXRpdGlzIGluIGEgcGhhc2UgMiB0cmlh

bDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5HYXN0cm9lbnRlcm9sb2d5PC9zZWNvbmRhcnktdGl0

bGU+PGFsdC10aXRsZT5HYXN0cm9lbnRlcm9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+R2FzdHJvZW50ZXJvbG9neTwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkdhc3Ryb2VudGVyb2xvZ3k8L2Z1bGwtdGl0

bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+Mzc3LTM4NDwvcGFnZXM+PHZvbHVtZT4xNDc8L3Zv

bHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkJpb3BzeSBEaXNlYXNlIFByb2dyZXNzaW9u

IERvdWJsZS1CbGluZCBNZXRob2QgRWljb3NhcGVudGFlbm9pYyBBY2lkL2FlIFtBZHZlcnNlIEVm

ZmVjdHNdICpFaWNvc2FwZW50YWVub2ljIEFjaWQvYWEgW0FuYWxvZ3MgJmFtcDsgRGVyaXZhdGl2

ZXNdIEVpY29zYXBlbnRhZW5vaWMgQWNpZC90dSBbVGhlcmFwZXV0aWMgVXNlXSBGYXR0eSBMaXZl

ci9jbyBbQ29tcGxpY2F0aW9uc10gKkZhdHR5IExpdmVyL2R0IFtEcnVnIFRoZXJhcHldIEZhdHR5

IExpPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48

aXNibj4xNTI4LTAwMTI8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDUz

L2ouZ2FzdHJvLjIwMTQuMDQuMDQ2O0NsaW5pY2FsIFRyaWFsLCBQaGFzZSBJSSBNdWx0aWNlbnRl

ciBTdHVkeSBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9u

LVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw

Oi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4m

YW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjQ4MTg3NjRodHRwOi8vc2Z4LnVj

bC5hYy51ay9zZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyNDgxODc2NCZh

bXA7aWQ9ZG9pOjEwLjEwNTMlMkZqLmdhc3Ryby4yMDE0LjA0LjA0NiZhbXA7aXNzbj0wMDE2LTUw

ODUmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTQ3JmFtcDtpc3N1ZT0yJmFtcDtzcGFnZT0zNzcmYW1w

O3BhZ2VzPTM3Ny04NC5lMSZhbXA7ZGF0ZT0yMDE0JmFtcDt0aXRsZT1HYXN0cm9lbnRlcm9sb2d5

JmFtcDthdGl0bGU9Tm8rc2lnbmlmaWNhbnQrZWZmZWN0cytvZitldGh5bC1laWNvc2FwZW50YW5v

aWMrYWNpZCtvbitoaXN0b2xvZ2ljK2ZlYXR1cmVzK29mK25vbmFsY29ob2xpYytzdGVhdG9oZXBh

dGl0aXMraW4rYStwaGFzZSsyK3RyaWFsLiZhbXA7YXVsYXN0PVNhbnlhbDwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (19)People with non-alcoholic steatohepatitis (NASH) & non-alcoholic fatty liver disease (NAFLD), USAEPA supplement, 0.9 g/d EPA LCn3 vs unclear86 int, 82 cont1 yearEPOCH – Danthiir 2011 ADDIN EN.CITE <EndNote><Cite><Author>Danthiir</Author><Year>2014</Year><RecNum>18314</RecNum><DisplayText>(6)</DisplayText><record><rec-number>18314</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530304097">18314</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Danthiir, V.</author><author>Hosking, D.</author><author>Burns, N. R.</author><author>Wilson, C.</author><author>Nettelbeck, T.</author><author>Calvaresi, E.</author><author>et, a l</author></authors></contributors><titles><title>Cognitive performance in older adults is inversely associated with fish consumption but not erythrocyte membrane n-3 fatty acids</title><secondary-title>The Journal of nutrition</secondary-title></titles><periodical><full-title>Journal of Nutrition</full-title><abbr-1>J Nutr</abbr-1><abbr-2>The journal of nutrition</abbr-2></periodical><pages>311-320</pages><volume>144</volume><number>3</number><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>(6)Healthy older adults with no cognitive impairment, AustraliaEPA & DHA supplement, 0.6 g/d EPA & 1.72 g/d DHALCn3 vs MUFA195 int, 196 cont1.5 yearsFerreira 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZXJyZWlyYTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

PFJlY051bT40Nzk1PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyMCk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NDc5NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjEyMDYxIj40Nzk1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5GZXJyZWlyYSwgSi4gSi48L2F1dGhvcj48YXV0aG9yPlJvc3NlciwgQS48L2F1dGhvcj48YXV0

aG9yPkNyYXVmdXJkLCBELjwvYXV0aG9yPjxhdXRob3I+U3F1aXRpZXJpLCBGLjwvYXV0aG9yPjxh

dXRob3I+TWFsbGFyZCwgTi48L2F1dGhvcj48YXV0aG9yPkxhbmR3ZWhybWV5ZXIsIEIuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RmVycmVpcmEsSm9hcXVp

bSBKLiBDbGluaWNhbCBQaGFybWFjb2xvZ3kgVW5pdCwgSW5zdGl0dXRvIGRlIE1lZGljaW5hIE1v

bGVjdWxhciwgRmFjdWx0eSBvZiBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBMaXNib24sIFBvcnR1

Z2FsLiBSb3NzZXIsQW5uZS4gQ2FyZGlmZiBTY2hvb2xzIG9mIE1lZGljaW5lIGFuZCBCaW9zY2ll

bmNlcywgQ2FyZGlmZiBVbml2ZXJzaXR5LCBVbml0ZWQgS2luZ2RvbS4gQ3JhdWZ1cmQsRGF2aWQu

IFVuaXZlcnNpdHkgb2YgTWFuY2hlc3RlciwgTWFuY2hlc3RlciBBY2FkZW1pYyBIZWFsdGggU2Np

ZW5jZXMgQ2VudGVyIGFuZCBDZW50cmFsIE1hbmNoZXN0ZXIgVW5pdmVyc2l0eSBIb3NwaXRhbHMg

TkhTIEZvdW5kYXRpb24gVHJ1c3QsIE1hbmNoZXN0ZXIsIFVuaXRlZCBLaW5nZG9tLiBTcXVpdGll

cmksRmVyZGluYW5kby4gSVJDU1MgTmV1cm9tZWQsIFBvenppbGxpLCBJdGFseS4gTWFsbGFyZCxO

aWNob2xhcy4gQW1hcmluIFBoYXJtYSBJbmMuLCBCZWRtaW5zdGVyLCBOZXcgSmVyc2V5LCBVU0Eu

IExhbmR3ZWhybWV5ZXIsQmVybmhhcmQuIFVuaXZlcnNpdGF0c2tsaW5payBVbG0sIFVsbSwgR2Vy

bWFueTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkV0aHlsLWVpY29zYXBlbnRhZW5vaWMg

YWNpZCB0cmVhdG1lbnQgaW4gSHVudGluZ3RvbiZhcG9zO3MgZGlzZWFzZTogQSBwbGFjZWJvLWNv

bnRyb2xsZWQgY2xpbmljYWwgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TW92ZW1lbnQg

RGlzb3JkZXJzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Nb3YgRGlzb3JkPC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TW92ZW1lbnQgZGlzb3JkZXJzIDog

b2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgTW92ZW1lbnQgRGlzb3JkZXIgU29jaWV0eTwvZnVsbC10

aXRsZT48YWJici0xPk1vdiBEaXNvcmQ8L2FiYnItMT48YWJici0yPk1vdmVtZW50IERpc29yZGVy

czwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TW92ZW1l

bnQgZGlzb3JkZXJzIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgTW92ZW1lbnQgRGlzb3JkZXIg

U29jaWV0eTwvZnVsbC10aXRsZT48YWJici0xPk1vdiBEaXNvcmQ8L2FiYnItMT48YWJici0yPk1v

dmVtZW50IERpc29yZGVyczwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE0MjYtMTQy

OTwvcGFnZXM+PHZvbHVtZT4zMDwvdm9sdW1lPjxudW1iZXI+MTA8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk

dWx0IEFnZWQgRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvc2FwZW50YWVub2ljIEFjaWQvYWQgW0Fk

bWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gKkVpY29zYXBlbnRhZW5vaWMgQWNpZC9hYSBbQW5h

bG9ncyAmYW1wOyBEZXJpdmF0aXZlc10gRWljb3NhcGVudGFlbm9pYyBBY2lkL3BkIFtQaGFybWFj

b2xvZ3ldIEZlbWFsZSBIdW1hbnMgKkh1bnRpbmd0b24gRGlzZWFzZS9kdCBbRHJ1ZyBUaGVyYXB5

XSBNYWxlIE1pZGRsZSBBZ2VkICpPdXRjb21lIEFzczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDE1PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTUzMS04MjU3PC9pc2JuPjx3b3JrLXR5

cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9tZHMuMjYzMDg7TXVsdGljZW50ZXIgU3R1ZHkg

UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRz

cC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdF

PWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI2MTc1MzMyaHR0cDovL3NmeC51Y2wuYWMudWsv

c2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYxNzUzMzImYW1wO2lkPWRv

aToxMC4xMDAyJTJGbWRzLjI2MzA4JmFtcDtpc3NuPTA4ODUtMzE4NSZhbXA7aXNibj0mYW1wO3Zv

bHVtZT0zMCZhbXA7aXNzdWU9MTAmYW1wO3NwYWdlPTE0MjYmYW1wO3BhZ2VzPTE0MjYtOSZhbXA7

ZGF0ZT0yMDE1JmFtcDt0aXRsZT1Nb3ZlbWVudCtEaXNvcmRlcnMmYW1wO2F0aXRsZT1FdGh5bC1l

aWNvc2FwZW50YWVub2ljK2FjaWQrdHJlYXRtZW50K2luK0h1bnRpbmd0b24lMjdzK2Rpc2Vhc2Ul

M0ErQStwbGFjZWJvLWNvbnRyb2xsZWQrY2xpbmljYWwrdHJpYWwuJmFtcDthdWxhc3Q9RmVycmVp

cmE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZXJyZWlyYTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

PFJlY051bT40Nzk1PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyMCk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NDc5NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjEyMDYxIj40Nzk1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5GZXJyZWlyYSwgSi4gSi48L2F1dGhvcj48YXV0aG9yPlJvc3NlciwgQS48L2F1dGhvcj48YXV0

aG9yPkNyYXVmdXJkLCBELjwvYXV0aG9yPjxhdXRob3I+U3F1aXRpZXJpLCBGLjwvYXV0aG9yPjxh

dXRob3I+TWFsbGFyZCwgTi48L2F1dGhvcj48YXV0aG9yPkxhbmR3ZWhybWV5ZXIsIEIuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RmVycmVpcmEsSm9hcXVp

bSBKLiBDbGluaWNhbCBQaGFybWFjb2xvZ3kgVW5pdCwgSW5zdGl0dXRvIGRlIE1lZGljaW5hIE1v

bGVjdWxhciwgRmFjdWx0eSBvZiBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBMaXNib24sIFBvcnR1

Z2FsLiBSb3NzZXIsQW5uZS4gQ2FyZGlmZiBTY2hvb2xzIG9mIE1lZGljaW5lIGFuZCBCaW9zY2ll

bmNlcywgQ2FyZGlmZiBVbml2ZXJzaXR5LCBVbml0ZWQgS2luZ2RvbS4gQ3JhdWZ1cmQsRGF2aWQu

IFVuaXZlcnNpdHkgb2YgTWFuY2hlc3RlciwgTWFuY2hlc3RlciBBY2FkZW1pYyBIZWFsdGggU2Np

ZW5jZXMgQ2VudGVyIGFuZCBDZW50cmFsIE1hbmNoZXN0ZXIgVW5pdmVyc2l0eSBIb3NwaXRhbHMg

TkhTIEZvdW5kYXRpb24gVHJ1c3QsIE1hbmNoZXN0ZXIsIFVuaXRlZCBLaW5nZG9tLiBTcXVpdGll

cmksRmVyZGluYW5kby4gSVJDU1MgTmV1cm9tZWQsIFBvenppbGxpLCBJdGFseS4gTWFsbGFyZCxO

aWNob2xhcy4gQW1hcmluIFBoYXJtYSBJbmMuLCBCZWRtaW5zdGVyLCBOZXcgSmVyc2V5LCBVU0Eu

IExhbmR3ZWhybWV5ZXIsQmVybmhhcmQuIFVuaXZlcnNpdGF0c2tsaW5payBVbG0sIFVsbSwgR2Vy

bWFueTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkV0aHlsLWVpY29zYXBlbnRhZW5vaWMg

YWNpZCB0cmVhdG1lbnQgaW4gSHVudGluZ3RvbiZhcG9zO3MgZGlzZWFzZTogQSBwbGFjZWJvLWNv

bnRyb2xsZWQgY2xpbmljYWwgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TW92ZW1lbnQg

RGlzb3JkZXJzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Nb3YgRGlzb3JkPC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TW92ZW1lbnQgZGlzb3JkZXJzIDog

b2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgTW92ZW1lbnQgRGlzb3JkZXIgU29jaWV0eTwvZnVsbC10

aXRsZT48YWJici0xPk1vdiBEaXNvcmQ8L2FiYnItMT48YWJici0yPk1vdmVtZW50IERpc29yZGVy

czwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TW92ZW1l

bnQgZGlzb3JkZXJzIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgTW92ZW1lbnQgRGlzb3JkZXIg

U29jaWV0eTwvZnVsbC10aXRsZT48YWJici0xPk1vdiBEaXNvcmQ8L2FiYnItMT48YWJici0yPk1v

dmVtZW50IERpc29yZGVyczwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE0MjYtMTQy

OTwvcGFnZXM+PHZvbHVtZT4zMDwvdm9sdW1lPjxudW1iZXI+MTA8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk

dWx0IEFnZWQgRG91YmxlLUJsaW5kIE1ldGhvZCBFaWNvc2FwZW50YWVub2ljIEFjaWQvYWQgW0Fk

bWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gKkVpY29zYXBlbnRhZW5vaWMgQWNpZC9hYSBbQW5h

bG9ncyAmYW1wOyBEZXJpdmF0aXZlc10gRWljb3NhcGVudGFlbm9pYyBBY2lkL3BkIFtQaGFybWFj

b2xvZ3ldIEZlbWFsZSBIdW1hbnMgKkh1bnRpbmd0b24gRGlzZWFzZS9kdCBbRHJ1ZyBUaGVyYXB5

XSBNYWxlIE1pZGRsZSBBZ2VkICpPdXRjb21lIEFzczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDE1PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTUzMS04MjU3PC9pc2JuPjx3b3JrLXR5

cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9tZHMuMjYzMDg7TXVsdGljZW50ZXIgU3R1ZHkg

UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv

diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRz

cC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdF

PWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI2MTc1MzMyaHR0cDovL3NmeC51Y2wuYWMudWsv

c2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYxNzUzMzImYW1wO2lkPWRv

aToxMC4xMDAyJTJGbWRzLjI2MzA4JmFtcDtpc3NuPTA4ODUtMzE4NSZhbXA7aXNibj0mYW1wO3Zv

bHVtZT0zMCZhbXA7aXNzdWU9MTAmYW1wO3NwYWdlPTE0MjYmYW1wO3BhZ2VzPTE0MjYtOSZhbXA7

ZGF0ZT0yMDE1JmFtcDt0aXRsZT1Nb3ZlbWVudCtEaXNvcmRlcnMmYW1wO2F0aXRsZT1FdGh5bC1l

aWNvc2FwZW50YWVub2ljK2FjaWQrdHJlYXRtZW50K2luK0h1bnRpbmd0b24lMjdzK2Rpc2Vhc2Ul

M0ErQStwbGFjZWJvLWNvbnRyb2xsZWQrY2xpbmljYWwrdHJpYWwuJmFtcDthdWxhc3Q9RmVycmVp

cmE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (20)Adults with Huntington's disease, 6 European countriesEPA supplement, 2.0 g/d EPA LCn3 vs unclear147 int, 143 cont0.5 yearsHashimoto 2016 ADDIN EN.CITE <EndNote><Cite><Author>Hashimoto</Author><Year>2016</Year><RecNum>20223</RecNum><DisplayText>(21)</DisplayText><record><rec-number>20223</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530355534">20223</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hashimoto, M.</author><author>Kato, S.</author><author>Tanabe, Y.</author><author>Katakura, M.</author><author>Mamun, A. A.</author><author>Ohno, M.</author><author>et, a l</author></authors></contributors><titles><title>Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes</title><secondary-title>Geriatrics &amp; Gerontology International</secondary-title></titles><periodical><full-title>Geriatrics and Gerontology International</full-title><abbr-1>Geriatr Gerontol Int</abbr-1><abbr-2>Geriatrics &amp; Gerontology International</abbr-2></periodical><pages>330-337</pages><volume>17</volume><number>2</number><dates><year>2016</year></dates><urls></urls></record></Cite></EndNote>(21)Healthy older people, JapanEPA & DHA supplement, 0.18 g/d EPA & 0.81 g/d DHALCn3 vs MUFA43 int, 32 cont1 yearJackson 2016 ADDIN EN.CITE <EndNote><Cite><Author>Jackson</Author><Year>2016</Year><RecNum>20220</RecNum><DisplayText>(22)</DisplayText><record><rec-number>20220</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530355532">20220</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jackson, P. A.</author><author>Forster, J. S.</author><author>Bell, J. G.</author><author>Dick, J. R.</author><author>Younger, I.</author><author>Kennedy, D. O.</author></authors></contributors><titles><title>DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults</title><secondary-title>Nutrients</secondary-title></titles><periodical><full-title>Nutrients</full-title></periodical><pages>86-86</pages><volume>8</volume><dates><year>2016</year></dates><urls></urls></record></Cite></EndNote>(22)Healthy adults with subjective memory deficit, UKEPA & DHA supplement, 0.13 g/d EPA & 0.90 g/d DHALCn3 vs MUFA33 int, 32 cont0.5 yearsLee 2012PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO

dW0+OTEyODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjMpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjkxMjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxNDQ5NCI+OTEyODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGVl

LCBTLiBQLjwvYXV0aG9yPjxhdXRob3I+RGFydCwgQS4gTS48L2F1dGhvcj48YXV0aG9yPldhbGtl

ciwgSy4gWi48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztEZWEsIEsuPC9hdXRob3I+PGF1dGhvcj5D

aGluLUR1c3RpbmcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5Ta2lsdG9uLCBNLiBSLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkxlZSxTYWJyaW5hIFAgUy4g

QmFrZXIgSURJIEhlYXJ0IGFuZCBEaWFiZXRlcyBJbnN0aXR1dGUsIFN0IEtpbGRhIFJvYWQgQ2Vu

dHJhbCwgTWVsYm91cm5lLCBWSUMgODAwOCwgQXVzdHJhbGlhPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0IG9mIGFsdGVyaW5nIGRpZXRhcnkgbi02Om4tMyBQVUZBIHJhdGlvIG9u

IGNhcmRpb3Zhc2N1bGFyIHJpc2sgbWVhc3VyZXMgaW4gcGF0aWVudHMgdHJlYXRlZCB3aXRoIHN0

YXRpbnM6IGEgcGlsb3Qgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3Vy

bmFsIG9mIE51dHJpdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9h

bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFs

IG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVy

aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51

dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjEyODAtMTI4NTwvcGFnZXM+PHZvbHVtZT4xMDg8L3ZvbHVtZT48bnVtYmVy

Pjc8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0IEFwb2xpcG9wcm90ZWluIEEtSS9ibCBbQmxvb2RdIEFw

b2xpcG9wcm90ZWlucyBCL2JsIFtCbG9vZF0gQy1SZWFjdGl2ZSBQcm90ZWluL2FuIFtBbmFseXNp

c10gKkNhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzL2VwIFtFcGlkZW1pb2xvZ3ldIENhcmRpb3Zhc2N1

bGFyIERpc2Vhc2VzL2V0IFtFdGlvbG9neV0gQ2hvbGVzdGVyb2wsTERML2JsIFtCbG9vZF0gQ29t

YmluZWQgTW9kYWxpdHkgVGhlcmFweSBDcm9zcy1PdmVyIFN0dWRpZXMgRGk8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48L2RhdGVzPjxpc2JuPjE0NzUtMjY2Mjwv

aXNibj48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsIFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtB

Tj0yMjE4MjQ4Mmh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjIyMTgyNDgyJmFtcDtpZD1kb2k6JmFtcDtpc3NuPTAwMDctMTE0NSZhbXA7

aXNibj0mYW1wO3ZvbHVtZT0xMDgmYW1wO2lzc3VlPTcmYW1wO3NwYWdlPTEyODAmYW1wO3BhZ2Vz

PTEyODAtNSZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRsZT1Ccml0aXNoK0pvdXJuYWwrb2YrTnV0cml0

aW9uJmFtcDthdGl0bGU9RWZmZWN0K29mK2FsdGVyaW5nK2RpZXRhcnkrbi02JTNBbi0zK1BVRkEr

cmF0aW8rb24rY2FyZGlvdmFzY3VsYXIrcmlzayttZWFzdXJlcytpbitwYXRpZW50cyt0cmVhdGVk

K3dpdGgrc3RhdGlucyUzQSthK3BpbG90K3N0dWR5LiZhbXA7YXVsYXN0PUxlZTwvdXJsPjwvcmVs

YXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO

dW0+OTEyODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjMpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjkxMjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0iMTUz

MDIxNDQ5NCI+OTEyODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGVl

LCBTLiBQLjwvYXV0aG9yPjxhdXRob3I+RGFydCwgQS4gTS48L2F1dGhvcj48YXV0aG9yPldhbGtl

ciwgSy4gWi48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztEZWEsIEsuPC9hdXRob3I+PGF1dGhvcj5D

aGluLUR1c3RpbmcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5Ta2lsdG9uLCBNLiBSLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkxlZSxTYWJyaW5hIFAgUy4g

QmFrZXIgSURJIEhlYXJ0IGFuZCBEaWFiZXRlcyBJbnN0aXR1dGUsIFN0IEtpbGRhIFJvYWQgQ2Vu

dHJhbCwgTWVsYm91cm5lLCBWSUMgODAwOCwgQXVzdHJhbGlhPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RWZmZWN0IG9mIGFsdGVyaW5nIGRpZXRhcnkgbi02Om4tMyBQVUZBIHJhdGlvIG9u

IGNhcmRpb3Zhc2N1bGFyIHJpc2sgbWVhc3VyZXMgaW4gcGF0aWVudHMgdHJlYXRlZCB3aXRoIHN0

YXRpbnM6IGEgcGlsb3Qgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3Vy

bmFsIG9mIE51dHJpdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9h

bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFs

IG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVy

aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51

dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjEyODAtMTI4NTwvcGFnZXM+PHZvbHVtZT4xMDg8L3ZvbHVtZT48bnVtYmVy

Pjc8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0IEFwb2xpcG9wcm90ZWluIEEtSS9ibCBbQmxvb2RdIEFw

b2xpcG9wcm90ZWlucyBCL2JsIFtCbG9vZF0gQy1SZWFjdGl2ZSBQcm90ZWluL2FuIFtBbmFseXNp

c10gKkNhcmRpb3Zhc2N1bGFyIERpc2Vhc2VzL2VwIFtFcGlkZW1pb2xvZ3ldIENhcmRpb3Zhc2N1

bGFyIERpc2Vhc2VzL2V0IFtFdGlvbG9neV0gQ2hvbGVzdGVyb2wsTERML2JsIFtCbG9vZF0gQ29t

YmluZWQgTW9kYWxpdHkgVGhlcmFweSBDcm9zcy1PdmVyIFN0dWRpZXMgRGk8L2tleXdvcmQ+PC9r

ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48L2RhdGVzPjxpc2JuPjE0NzUtMjY2Mjwv

aXNibj48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsIFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtB

Tj0yMjE4MjQ4Mmh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjIyMTgyNDgyJmFtcDtpZD1kb2k6JmFtcDtpc3NuPTAwMDctMTE0NSZhbXA7

aXNibj0mYW1wO3ZvbHVtZT0xMDgmYW1wO2lzc3VlPTcmYW1wO3NwYWdlPTEyODAmYW1wO3BhZ2Vz

PTEyODAtNSZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRsZT1Ccml0aXNoK0pvdXJuYWwrb2YrTnV0cml0

aW9uJmFtcDthdGl0bGU9RWZmZWN0K29mK2FsdGVyaW5nK2RpZXRhcnkrbi02JTNBbi0zK1BVRkEr

cmF0aW8rb24rY2FyZGlvdmFzY3VsYXIrcmlzayttZWFzdXJlcytpbitwYXRpZW50cyt0cmVhdGVk

K3dpdGgrc3RhdGlucyUzQSthK3BpbG90K3N0dWR5LiZhbXA7YXVsYXN0PUxlZTwvdXJsPjwvcmVs

YXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (23)People aged ≥60 years, low to middle socioeconomic status, MalaysiaEPA & DHA supplement, 0.15 g/d EPA & 0.43 g/d DHALCn3 vs n618 int, 18 cont1 yearMAPT – Vellas 2017 ADDIN EN.CITE <EndNote><Cite><Author>Andrieu</Author><Year>2017</Year><RecNum>21994</RecNum><DisplayText>(14)</DisplayText><record><rec-number>21994</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1550077986">21994</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Andrieu, Sandrine</author><author>Guyonnet, Sophie</author><author>Coley, Nicola</author><author>Cantet, Christelle</author><author>Bonnefoy, Marc</author><author>Bordes, Serge</author><author>Bories, Lawrence</author><author>Cufi, Marie-No?lle</author><author>Dantoine, Thierry</author><author>Dartigues, Jean-Fran?ois</author><author>Desclaux, Fran?oise</author><author>Gabelle, Audrey</author><author>Gasnier, Yannick</author><author>Pesce, Alain</author><author>Sudres, Kristel</author><author>Touchon, Jacques</author><author>Robert, Philippe</author><author>Rouaud, Olivier</author><author>Legrand, Philippe</author><author>Payoux, Pierre</author><author>Caubere, Jean-Paul</author><author>Weiner, Michael</author><author>Carrié, Isabelle</author><author>Ousset, Pierre-Jean</author><author>Vellas, Bruno</author></authors></contributors><titles><title>Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial</title><secondary-title>The Lancet Neurology</secondary-title></titles><periodical><full-title>The Lancet Neurology</full-title><abbr-1>Lancet Neurol</abbr-1><abbr-2>The Lancet. Neurology</abbr-2></periodical><pages>377-389</pages><volume>16</volume><number>5</number><dates><year>2017</year></dates><publisher>Elsevier</publisher><isbn>1474-4422</isbn><urls><related-urls><url>(17)30040-6</url></related-urls></urls><electronic-resource-num>DOI: 10.1016/S1474-4422(17)30040-6</electronic-resource-num><access-date>2019/02/13</access-date></record></Cite></EndNote>(14)People aged ≥70 years with memory complaint, IADL limitation or slow gait speed, France & MonacoEPA & DHA supplement, 0.23 g/d EPA & 0.80 g/d DHALCn3 vs non-fat840 int, 840 cont3 yearsMEMO – Van de Rest 2008PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYW4gRGUgUmVzdDwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT4xNjQ1MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDEpPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjE2NDUyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1l

c3RhbXA9IjE1MzAyMTg2NDIiPjE2NDUyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h

bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+

PGF1dGhvcj5WYW4gRGUgUmVzdCwgTy48L2F1dGhvcj48YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48

L2F1dGhvcj48YXV0aG9yPktvaywgRi4gSi48L2F1dGhvcj48YXV0aG9yPnZhbiBTdGF2ZXJlbiwg

Vy4gQS48L2F1dGhvcj48YXV0aG9yPkhvZWZuYWdlbHMsIFcuIEguPC9hdXRob3I+PGF1dGhvcj5C

ZWVrbWFuLCBBLiBULjwvYXV0aG9yPjxhdXRob3I+ZGUgR3Jvb3QsIEwuIEMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+dmFuIGRlIFJlc3QsT25kaW5lLiBX

YWdlbmluZ2VuIFVuaXZlcnNpdHksIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5p

bmdlbiwgTmV0aGVybGFuZHMuIG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGZpc2gtb2lsIHN1cHBsZW1lbnRhdGlvbiBvbiBtZW50

YWwgd2VsbC1iZWluZyBpbiBvbGRlciBzdWJqZWN0czogYSByYW5kb21pemVkLCBkb3VibGUtYmxp

bmQsIHBsYWNlYm8tY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVy

aWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQt

dGl0bGU+QW0gSiBDbGluIE51dHI8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvZnVsbC10aXRs

ZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSm91

cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9u

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0gSiBDbGluIE51dHI8L2FiYnItMT48YWJici0yPlRoZSBB

bWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvYWJici0yPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjcwNi03MTM8L3BhZ2VzPjx2b2x1bWU+ODg8L3ZvbHVtZT48bnVtYmVyPjM8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFnZWQgQW54aWV0eSBEZXByZXNzaW9uIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2Vd

IERvY29zYWhleGFlbm9pYyBBY2lkcy9ibCBbQmxvb2RdIERvY29zYWhleGFlbm9pYyBBY2lkcy9w

ZCBbUGhhcm1hY29sb2d5XSBEb3VibGUtQmxpbmQgTWV0aG9kIEVpY29zYXBlbnRhZW5vaWMgQWNp

ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBFaWNvc2FwZW50YWVubzwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzOC0z

MjA3PC9pc2JuPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNo

IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9

WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4Nzc5Mjg3

aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBt

aWQ6MTg3NzkyODcmYW1wO2lkPWRvaTomYW1wO2lzc249MDAwMi05MTY1JmFtcDtpc2JuPSZhbXA7

dm9sdW1lPTg4JmFtcDtpc3N1ZT0zJmFtcDtzcGFnZT03MDYmYW1wO3BhZ2VzPTcwNi0xMyZhbXA7

ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29mK0NsaW5pY2FsK051dHJpdGlv

biZhbXA7YXRpdGxlPUVmZmVjdCtvZitmaXNoLW9pbCtzdXBwbGVtZW50YXRpb24rb24rbWVudGFs

K3dlbGwtYmVpbmcraW4rb2xkZXIrc3ViamVjdHMlM0ErYStyYW5kb21pemVkJTJDK2RvdWJsZS1i

bGluZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFuK2RlK1Jlc3Q8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WYW4gRGUgUmVzdDwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT4xNjQ1MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDEpPC9EaXNwbGF5VGV4dD48

cmVjb3JkPjxyZWMtbnVtYmVyPjE2NDUyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1l

c3RhbXA9IjE1MzAyMTg2NDIiPjE2NDUyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h

bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+

PGF1dGhvcj5WYW4gRGUgUmVzdCwgTy48L2F1dGhvcj48YXV0aG9yPkdlbGVpam5zZSwgSi4gTS48

L2F1dGhvcj48YXV0aG9yPktvaywgRi4gSi48L2F1dGhvcj48YXV0aG9yPnZhbiBTdGF2ZXJlbiwg

Vy4gQS48L2F1dGhvcj48YXV0aG9yPkhvZWZuYWdlbHMsIFcuIEguPC9hdXRob3I+PGF1dGhvcj5C

ZWVrbWFuLCBBLiBULjwvYXV0aG9yPjxhdXRob3I+ZGUgR3Jvb3QsIEwuIEMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+dmFuIGRlIFJlc3QsT25kaW5lLiBX

YWdlbmluZ2VuIFVuaXZlcnNpdHksIERpdmlzaW9uIG9mIEh1bWFuIE51dHJpdGlvbiwgV2FnZW5p

bmdlbiwgTmV0aGVybGFuZHMuIG9uZGluZS52YW5kZXJlc3RAd3VyLm5sPC9hdXRoLWFkZHJlc3M+

PHRpdGxlcz48dGl0bGU+RWZmZWN0IG9mIGZpc2gtb2lsIHN1cHBsZW1lbnRhdGlvbiBvbiBtZW50

YWwgd2VsbC1iZWluZyBpbiBvbGRlciBzdWJqZWN0czogYSByYW5kb21pemVkLCBkb3VibGUtYmxp

bmQsIHBsYWNlYm8tY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVy

aWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQt

dGl0bGU+QW0gSiBDbGluIE51dHI8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvZnVsbC10aXRs

ZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSm91

cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9u

PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0gSiBDbGluIE51dHI8L2FiYnItMT48YWJici0yPlRoZSBB

bWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51dHJpdGlvbjwvYWJici0yPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjcwNi03MTM8L3BhZ2VzPjx2b2x1bWU+ODg8L3ZvbHVtZT48bnVtYmVyPjM8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFnZWQgQW54aWV0eSBEZXByZXNzaW9uIERpZXRhcnkgU3VwcGxlbWVu

dHMgRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2Vd

IERvY29zYWhleGFlbm9pYyBBY2lkcy9ibCBbQmxvb2RdIERvY29zYWhleGFlbm9pYyBBY2lkcy9w

ZCBbUGhhcm1hY29sb2d5XSBEb3VibGUtQmxpbmQgTWV0aG9kIEVpY29zYXBlbnRhZW5vaWMgQWNp

ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBFaWNvc2FwZW50YWVubzwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTkzOC0z

MjA3PC9pc2JuPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNo

IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11

cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9

WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4Nzc5Mjg3

aHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBt

aWQ6MTg3NzkyODcmYW1wO2lkPWRvaTomYW1wO2lzc249MDAwMi05MTY1JmFtcDtpc2JuPSZhbXA7

dm9sdW1lPTg4JmFtcDtpc3N1ZT0zJmFtcDtzcGFnZT03MDYmYW1wO3BhZ2VzPTcwNi0xMyZhbXA7

ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29mK0NsaW5pY2FsK051dHJpdGlv

biZhbXA7YXRpdGxlPUVmZmVjdCtvZitmaXNoLW9pbCtzdXBwbGVtZW50YXRpb24rb24rbWVudGFs

K3dlbGwtYmVpbmcraW4rb2xkZXIrc3ViamVjdHMlM0ErYStyYW5kb21pemVkJTJDK2RvdWJsZS1i

bGluZCUyQytwbGFjZWJvLWNvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9dmFuK2RlK1Jlc3Q8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (41)Independently living people aged ≥65 years, NetherlandsEPA & DHA supplement, 1.09 g/d EPA & 0.85 g/d DHA or 0.23 g/d EPA & 0.18 g/d DHALCn3 vs MUFA196 int, 106 cont0.5 yearsMIDAS – Yurko-Mauro 2010PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZdXJrby1NYXVybzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll

YXI+PFJlY051bT4xNzcyNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oOCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTc3MjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxOTQxOCI+MTc3MjQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPll1cmtvLU1hdXJvLCBLLjwvYXV0aG9yPjxhdXRob3I+TWNDYXJ0aHksIEQuPC9hdXRo

b3I+PGF1dGhvcj5Sb20sIEQuPC9hdXRob3I+PGF1dGhvcj5OZWxzb24sIEUuIEIuPC9hdXRob3I+

PGF1dGhvcj5SeWFuLCBBLiBTLjwvYXV0aG9yPjxhdXRob3I+QmxhY2t3ZWxsLCBBLjwvYXV0aG9y

PjxhdXRob3I+U2FsZW0sIE4uLCBKci48L2F1dGhvcj48YXV0aG9yPlN0ZWRtYW4sIE0uPC9hdXRo

b3I+PGF1dGhvcj5JbnZlc3RpZ2F0b3JzLCBNaWRhczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPll1cmtvLU1hdXJvLEthcmluLiBDbGluaWNhbCBSZXNlYXJj

aCBEZXBhcnRtZW50LCBNYXJ0ZWsgQmlvc2NpZW5jZXMgQ29ycG9yYXRpb24sIENvbHVtYmlhLCBN

RCwgVVNBLiBreXVya29AbWFydGVrLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkJl

bmVmaWNpYWwgZWZmZWN0cyBvZiBkb2Nvc2FoZXhhZW5vaWMgYWNpZCBvbiBjb2duaXRpb24gaW4g

YWdlLXJlbGF0ZWQgY29nbml0aXZlIGRlY2xpbmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QWx6

aGVpbWVyJmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlhPC9mdWxsLXRpdGxlPjxh

YmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJici0yPkFsemhlaW1lciZh

cG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWltZXJzIGFuZCBEZW1lbnRp

YTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QWx6aGVp

bWVyJmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvZnVsbC10aXRsZT48YWJici0xPkFsemhlaW1lciZh

cG9zO3MgZGVtZW50PC9hYmJyLTE+PGFiYnItMj5BbHpoZWltZXImYXBvcztzIGFuZCBEZW1lbnRp

YTwvYWJici0yPjxhYmJyLTM+QWx6aGVpbWVycyBhbmQgRGVtZW50aWE8L2FiYnItMz48L2FsdC1w

ZXJpb2RpY2FsPjxwYWdlcz40NTYtNDY0PC9wYWdlcz48dm9sdW1lPjY8L3ZvbHVtZT48bnVtYmVy

PjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkFnaW5nL2RlIFtEcnVnIEVmZmVjdHNdICpBZ2luZy9w

eCBbUHN5Y2hvbG9neV0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZGkgW0RpYWdub3Npc10gQ29nbml0

aW9uIERpc29yZGVycy9tZSBbTWV0YWJvbGlzbV0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvcGMgW1By

ZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGVtZW50aWEvZGkgW0RpYWdub3Npc10gRGVtZW50aWEv

ZHQgW0RydWcgVGhlcmFweV0gRGVtZW50aWEvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udDwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01Mjc5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMC4wMS4wMTM7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQs

IE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX

Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGMmYW1wO0FOPTIwNDM0OTYxaHR0cDovL3Nm

eC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjA0MzQ5

NjEmYW1wO2lkPWRvaToxMC4xMDE2JTJGai5qYWx6LjIwMTAuMDEuMDEzJmFtcDtpc3NuPTE1NTIt

NTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT02JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT00NTYmYW1w

O3BhZ2VzPTQ1Ni02NCZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1BbHpoZWltZXIlMjdzKyUyNitE

ZW1lbnRpYSZhbXA7YXRpdGxlPUJlbmVmaWNpYWwrZWZmZWN0cytvZitkb2Nvc2FoZXhhZW5vaWMr

YWNpZCtvbitjb2duaXRpb24raW4rYWdlLXJlbGF0ZWQrY29nbml0aXZlK2RlY2xpbmUuJmFtcDth

dWxhc3Q9WXVya28tTWF1cm88L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9D

aXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZdXJrby1NYXVybzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll

YXI+PFJlY051bT4xNzcyNDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oOCk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTc3MjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxOTQxOCI+MTc3MjQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPll1cmtvLU1hdXJvLCBLLjwvYXV0aG9yPjxhdXRob3I+TWNDYXJ0aHksIEQuPC9hdXRo

b3I+PGF1dGhvcj5Sb20sIEQuPC9hdXRob3I+PGF1dGhvcj5OZWxzb24sIEUuIEIuPC9hdXRob3I+

PGF1dGhvcj5SeWFuLCBBLiBTLjwvYXV0aG9yPjxhdXRob3I+QmxhY2t3ZWxsLCBBLjwvYXV0aG9y

PjxhdXRob3I+U2FsZW0sIE4uLCBKci48L2F1dGhvcj48YXV0aG9yPlN0ZWRtYW4sIE0uPC9hdXRo

b3I+PGF1dGhvcj5JbnZlc3RpZ2F0b3JzLCBNaWRhczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48YXV0aC1hZGRyZXNzPll1cmtvLU1hdXJvLEthcmluLiBDbGluaWNhbCBSZXNlYXJj

aCBEZXBhcnRtZW50LCBNYXJ0ZWsgQmlvc2NpZW5jZXMgQ29ycG9yYXRpb24sIENvbHVtYmlhLCBN

RCwgVVNBLiBreXVya29AbWFydGVrLmNvbTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkJl

bmVmaWNpYWwgZWZmZWN0cyBvZiBkb2Nvc2FoZXhhZW5vaWMgYWNpZCBvbiBjb2duaXRpb24gaW4g

YWdlLXJlbGF0ZWQgY29nbml0aXZlIGRlY2xpbmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QWx6

aGVpbWVyJmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5BbHpoZWltZXImYXBvcztzICZhbXA7IERlbWVudGlhPC9mdWxsLXRpdGxlPjxh

YmJyLTE+QWx6aGVpbWVyJmFwb3M7cyBkZW1lbnQ8L2FiYnItMT48YWJici0yPkFsemhlaW1lciZh

cG9zO3MgYW5kIERlbWVudGlhPC9hYmJyLTI+PGFiYnItMz5BbHpoZWltZXJzIGFuZCBEZW1lbnRp

YTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QWx6aGVp

bWVyJmFwb3M7cyAmYW1wOyBEZW1lbnRpYTwvZnVsbC10aXRsZT48YWJici0xPkFsemhlaW1lciZh

cG9zO3MgZGVtZW50PC9hYmJyLTE+PGFiYnItMj5BbHpoZWltZXImYXBvcztzIGFuZCBEZW1lbnRp

YTwvYWJici0yPjxhYmJyLTM+QWx6aGVpbWVycyBhbmQgRGVtZW50aWE8L2FiYnItMz48L2FsdC1w

ZXJpb2RpY2FsPjxwYWdlcz40NTYtNDY0PC9wYWdlcz48dm9sdW1lPjY8L3ZvbHVtZT48bnVtYmVy

PjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkFnaW5nL2RlIFtEcnVnIEVmZmVjdHNdICpBZ2luZy9w

eCBbUHN5Y2hvbG9neV0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvZGkgW0RpYWdub3Npc10gQ29nbml0

aW9uIERpc29yZGVycy9tZSBbTWV0YWJvbGlzbV0gKkNvZ25pdGlvbiBEaXNvcmRlcnMvcGMgW1By

ZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRGVtZW50aWEvZGkgW0RpYWdub3Npc10gRGVtZW50aWEv

ZHQgW0RydWcgVGhlcmFweV0gRGVtZW50aWEvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udDwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU1

Mi01Mjc5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmphbHou

MjAxMC4wMS4wMTM7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQs

IE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX

Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGMmYW1wO0FOPTIwNDM0OTYxaHR0cDovL3Nm

eC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjA0MzQ5

NjEmYW1wO2lkPWRvaToxMC4xMDE2JTJGai5qYWx6LjIwMTAuMDEuMDEzJmFtcDtpc3NuPTE1NTIt

NTI2MCZhbXA7aXNibj0mYW1wO3ZvbHVtZT02JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT00NTYmYW1w

O3BhZ2VzPTQ1Ni02NCZhbXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1BbHpoZWltZXIlMjdzKyUyNitE

ZW1lbnRpYSZhbXA7YXRpdGxlPUJlbmVmaWNpYWwrZWZmZWN0cytvZitkb2Nvc2FoZXhhZW5vaWMr

YWNpZCtvbitjb2duaXRpb24raW4rYWdlLXJlbGF0ZWQrY29nbml0aXZlK2RlY2xpbmUuJmFtcDth

dWxhc3Q9WXVya28tTWF1cm88L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9D

aXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (8)Healthy older people with subjective memory complaints, USADHA supplement, 0.90 g/d DHALCn3 vs n6242 int, 243 cont0.5 yearsNEURAPRO – McGorry 2017 ADDIN EN.CITE <EndNote><Cite><Author>McGorry</Author><Year>2017</Year><RecNum>20311</RecNum><DisplayText>(25)</DisplayText><record><rec-number>20311</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530355575">20311</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McGorry, P. D.</author><author>Nelson, B.</author><author>Markulev, C.</author><author>Yuen, H. P.</author><author>Sch?fer, M. R.</author><author>Mossaheb, N.</author><author>et, a l</author></authors></contributors><titles><title>Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders: The NEURAPRO Randomized Clinical Trial</title><secondary-title>JAMA Psychiatry</secondary-title></titles><periodical><full-title>JAMA Psychiatry</full-title></periodical><pages>19-27</pages><volume>74</volume><number>1</number><dates><year>2017</year></dates><urls></urls></record></Cite></EndNote>(25)Young people at ultra-high risk for psychotic disorders, Australia, Switzerland, Germany, China, Austria, Singapore, NetherlandsEPA & DHA supplement, 0.84 g/d EPA & 0.56 g/d DHALCn3 vs non-fat153 int, 151 cont0.5 yearsOFAMS – Torkildsen 2012PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub3JraWxkc2VuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh

cj48UmVjTnVtPjE2MDk2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyNik8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTYwOTY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxODQzNiI+MTYwOTY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPlRvcmtpbGRzZW4sIE8uPC9hdXRob3I+PGF1dGhvcj5XZXJnZWxhbmQsIFMuPC9hdXRo

b3I+PGF1dGhvcj5CYWtrZSwgUy48L2F1dGhvcj48YXV0aG9yPkJlaXNrZSwgQS4gRy48L2F1dGhv

cj48YXV0aG9yPkJqZXJ2ZSwgSy4gUy48L2F1dGhvcj48YXV0aG9yPkhvdmRhbCwgSC48L2F1dGhv

cj48YXV0aG9yPk1pZGdhcmQsIFIuPC9hdXRob3I+PGF1dGhvcj5MaWxsZWFzLCBGLjwvYXV0aG9y

PjxhdXRob3I+UGVkZXJzZW4sIFQuPC9hdXRob3I+PGF1dGhvcj5Cam9ybmFyYSwgQi48L2F1dGhv

cj48YXV0aG9yPkRhbGVuZSwgRi48L2F1dGhvcj48YXV0aG9yPktsZXZlbGFuZCwgRy48L2F1dGhv

cj48YXV0aG9yPlNjaGVwZWwsIEouPC9hdXRob3I+PGF1dGhvcj5PbHNlbiwgSS4gQy48L2F1dGhv

cj48YXV0aG9yPk15aHIsIEsuIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+VG9ya2lsZHNlbixPaXZpbmQuIE5vcndlZ2lhbiBNdWx0aXBsZSBTY2xlcm9z

aXMgQ29tcGV0ZW5jZSBDZW50cmUsIERlcGFydG1lbnQgb2YgTmV1cm9sb2d5LCBIYXVrZWxhbmQg

VW5pdmVyc2l0eSBIb3NwaXRhbCwgTm9yd2F5LiBvaXZpbmQudG9ya2lsZHNlbkBnbWFpbC5jb208

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5vbWVnYS0zIGZhdHR5IGFjaWQgdHJlYXRtZW50

IGluIG11bHRpcGxlIHNjbGVyb3NpcyAoT0ZBTVMgU3R1ZHkpOiBhIHJhbmRvbWl6ZWQsIGRvdWJs

ZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaCBO

ZXVyb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoaXZl

cyBvZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoIE5ldXJvbDwvYWJici0xPjwv

cGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJjaGl2ZXMgb2YgTmV1cm9s

b2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+QXJjaCBOZXVyb2w8L2FiYnItMT48L2FsdC1wZXJpb2Rp

Y2FsPjxwYWdlcz4xMDQ0LTEwNTE8L3BhZ2VzPjx2b2x1bWU+Njk8L3ZvbHVtZT48bnVtYmVyPjg8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkdWx0IERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJsaW5kIE1l

dGhvZCBEcnVnIFRoZXJhcHksQ29tYmluYXRpb24gKkZhdHR5IEFjaWRzLE9tZWdhLTMvYWQgW0Fk

bWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmVtYWxlIEh1bWFucyBJbnRlcmZlcm9uIGJldGEt

MWEgSW50ZXJmZXJvbi1iZXRhL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdIE1hZ25l

dGljIFJlc29uYW5jZSBJbWFnaW5nL3RkIFtUcmVuZHNdIE1hbGUgTWlkZGxlIEFnZTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTUzOC0z

Njg3PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMS9hcmNobmV1cm9s

LjIwMTIuMjgzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBS

ZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZh

bXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0y

MjUwNzg4Nmh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFt

cDtpZD1wbWlkOjIyNTA3ODg2JmFtcDtpZD1kb2k6MTAuMTAwMSUyRmFyY2huZXVyb2wuMjAxMi4y

ODMmYW1wO2lzc249MDAwMy05OTQyJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTY5JmFtcDtpc3N1ZT04

JmFtcDtzcGFnZT0xMDQ0JmFtcDtwYWdlcz0xMDQ0LTUxJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxl

PUFyY2hpdmVzK29mK05ldXJvbG9neSZhbXA7YXRpdGxlPW9tZWdhLTMrZmF0dHkrYWNpZCt0cmVh

dG1lbnQraW4rbXVsdGlwbGUrc2NsZXJvc2lzKyUyOE9GQU1TK1N0dWR5JTI5JTNBK2ErcmFuZG9t

aXplZCUyQytkb3VibGUtYmxpbmQlMkMrcGxhY2Viby1jb250cm9sbGVkK3RyaWFsLiZhbXA7YXVs

YXN0PVRvcmtpbGRzZW48L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub3JraWxkc2VuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh

cj48UmVjTnVtPjE2MDk2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyNik8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MTYwOTY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVz

dGFtcD0iMTUzMDIxODQzNiI+MTYwOTY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPlRvcmtpbGRzZW4sIE8uPC9hdXRob3I+PGF1dGhvcj5XZXJnZWxhbmQsIFMuPC9hdXRo

b3I+PGF1dGhvcj5CYWtrZSwgUy48L2F1dGhvcj48YXV0aG9yPkJlaXNrZSwgQS4gRy48L2F1dGhv

cj48YXV0aG9yPkJqZXJ2ZSwgSy4gUy48L2F1dGhvcj48YXV0aG9yPkhvdmRhbCwgSC48L2F1dGhv

cj48YXV0aG9yPk1pZGdhcmQsIFIuPC9hdXRob3I+PGF1dGhvcj5MaWxsZWFzLCBGLjwvYXV0aG9y

PjxhdXRob3I+UGVkZXJzZW4sIFQuPC9hdXRob3I+PGF1dGhvcj5Cam9ybmFyYSwgQi48L2F1dGhv

cj48YXV0aG9yPkRhbGVuZSwgRi48L2F1dGhvcj48YXV0aG9yPktsZXZlbGFuZCwgRy48L2F1dGhv

cj48YXV0aG9yPlNjaGVwZWwsIEouPC9hdXRob3I+PGF1dGhvcj5PbHNlbiwgSS4gQy48L2F1dGhv

cj48YXV0aG9yPk15aHIsIEsuIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh

dXRoLWFkZHJlc3M+VG9ya2lsZHNlbixPaXZpbmQuIE5vcndlZ2lhbiBNdWx0aXBsZSBTY2xlcm9z

aXMgQ29tcGV0ZW5jZSBDZW50cmUsIERlcGFydG1lbnQgb2YgTmV1cm9sb2d5LCBIYXVrZWxhbmQg

VW5pdmVyc2l0eSBIb3NwaXRhbCwgTm9yd2F5LiBvaXZpbmQudG9ya2lsZHNlbkBnbWFpbC5jb208

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5vbWVnYS0zIGZhdHR5IGFjaWQgdHJlYXRtZW50

IGluIG11bHRpcGxlIHNjbGVyb3NpcyAoT0ZBTVMgU3R1ZHkpOiBhIHJhbmRvbWl6ZWQsIGRvdWJs

ZS1ibGluZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkFyY2hpdmVzIG9mIE5ldXJvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaCBO

ZXVyb2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoaXZl

cyBvZiBOZXVyb2xvZ3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoIE5ldXJvbDwvYWJici0xPjwv

cGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJjaGl2ZXMgb2YgTmV1cm9s

b2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+QXJjaCBOZXVyb2w8L2FiYnItMT48L2FsdC1wZXJpb2Rp

Y2FsPjxwYWdlcz4xMDQ0LTEwNTE8L3BhZ2VzPjx2b2x1bWU+Njk8L3ZvbHVtZT48bnVtYmVyPjg8

L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkdWx0IERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJsaW5kIE1l

dGhvZCBEcnVnIFRoZXJhcHksQ29tYmluYXRpb24gKkZhdHR5IEFjaWRzLE9tZWdhLTMvYWQgW0Fk

bWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmVtYWxlIEh1bWFucyBJbnRlcmZlcm9uIGJldGEt

MWEgSW50ZXJmZXJvbi1iZXRhL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdIE1hZ25l

dGljIFJlc29uYW5jZSBJbWFnaW5nL3RkIFtUcmVuZHNdIE1hbGUgTWlkZGxlIEFnZTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTUzOC0z

Njg3PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMS9hcmNobmV1cm9s

LjIwMTIuMjgzO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBS

ZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZh

bXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0y

MjUwNzg4Nmh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFt

cDtpZD1wbWlkOjIyNTA3ODg2JmFtcDtpZD1kb2k6MTAuMTAwMSUyRmFyY2huZXVyb2wuMjAxMi4y

ODMmYW1wO2lzc249MDAwMy05OTQyJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTY5JmFtcDtpc3N1ZT04

JmFtcDtzcGFnZT0xMDQ0JmFtcDtwYWdlcz0xMDQ0LTUxJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxl

PUFyY2hpdmVzK29mK05ldXJvbG9neSZhbXA7YXRpdGxlPW9tZWdhLTMrZmF0dHkrYWNpZCt0cmVh

dG1lbnQraW4rbXVsdGlwbGUrc2NsZXJvc2lzKyUyOE9GQU1TK1N0dWR5JTI5JTNBK2ErcmFuZG9t

aXplZCUyQytkb3VibGUtYmxpbmQlMkMrcGxhY2Viby1jb250cm9sbGVkK3RyaWFsLiZhbXA7YXVs

YXN0PVRvcmtpbGRzZW48L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (26)People with relapsing remitting multiple sclerosis, NorwayEPA & DHA supplement, 1.35 g/d EPA & 0.85 g/d DHALCn3 vs n646 int, 46 cont0.5 yearsOFFER – Pawelczyk 2015PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXdlbGN6eWs8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy

PjxSZWNOdW0+MTI0MjA8L1JlY051bT48RGlzcGxheVRleHQ+KDkpPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjEyNDIwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTYzNDEiPjEyNDIwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5QYXdlbGN6eWssIFQuPC9hdXRob3I+PGF1dGhvcj5HcmFuY293LUdyYWJrYSwgTS48L2F1

dGhvcj48YXV0aG9yPktvdGxpY2thLUFudGN6YWssIE0uPC9hdXRob3I+PGF1dGhvcj5UcmFmYWxz

a2EsIEUuPC9hdXRob3I+PGF1dGhvcj5QYXdlbGN6eWssIEEuPC9hdXRob3I+PC9hdXRob3JzPjwv

Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGF3ZWxjenlrLFRvbWFzei4gRGVwYXJ0bWVudCBv

ZiBBZmZlY3RpdmUgYW5kIFBzeWNob3RpYyBEaXNvcmRlcnMsIE1lZGljYWwgVW5pdmVyc2l0eSBv

ZiBMb2R6LCB1bC4gQ3plY2hvc2xvd2Fja2EgOC8xMCwgOTItMjE2IExvZHosIFBvbGFuZC4gRWxl

Y3Ryb25pYyBhZGRyZXNzOiB0b21hc3oucGF3ZWxjenlrQHVtZWQubG9kei5wbC4gR3JhbmNvdy1H

cmFia2EsTWFydGEuIENlbnRyYWwgVGVhY2hpbmcgSG9zcGl0YWwsIE1lZGljYWwgVW5pdmVyc2l0

eSBvZiBMb2R6LCB1bC4gUG9tb3Jza2EgMjUxLCA5Mi0yMTMgTG9keiwgUG9sYW5kLiBFbGVjdHJv

bmljIGFkZHJlc3M6IG1hcnRhZ3JhbmNvd0BnbWFpbC5jb20uIEtvdGxpY2thLUFudGN6YWssTWFn

ZGFsZW5hLiBEZXBhcnRtZW50IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywg

TWVkaWNhbCBVbml2ZXJzaXR5IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0y

MTYgTG9keiwgUG9sYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IG1hZ2RhbGVuYS5rb3RsaWNrYS1h

bnRjemFrQHVtZWQubG9kei5wbC4gVHJhZmFsc2thLEVsemJpZXRhLiBEZXBhcnRtZW50IG9mIE51

dHJpdGlvbiBIeWdpZW5lIGFuZCBFcGlkZW1pb2xvZ3ksIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBM

b2R6LCB1bC4gSmFyYWN6YSA2MywgOTAtMjUxIExvZHosIFBvbGFuZC4gRWxlY3Ryb25pYyBhZGRy

ZXNzOiBlbHpiaWV0YS50cmFmYWxza2FAdW1lZC5sb2R6LnBsLiBQYXdlbGN6eWssQWduaWVzemth

LiBEZXBhcnRtZW50IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywgTWVkaWNh

bCBVbml2ZXJzaXR5IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0yMTYgTG9k

eiwgUG9sYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IGFnbmllc3prYS5wYXdlbGN6eWtAdW1lZC5s

b2R6LnBsPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSByYW5kb21pemVkIGNvbnRyb2xs

ZWQgc3R1ZHkgb2YgdGhlIGVmZmljYWN5IG9mIHNpeC1tb250aCBzdXBwbGVtZW50YXRpb24gd2l0

aCBjb25jZW50cmF0ZWQgZmlzaCBvaWwgcmljaCBpbiBvbWVnYS0zIHBvbHl1bnNhdHVyYXRlZCBm

YXR0eSBhY2lkcyBpbiBmaXJzdCBlcGlzb2RlIHNjaGl6b3BocmVuaWE8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvc2Vjb25kYXJ5LXRpdGxl

PjxhbHQtdGl0bGU+SiBQc3ljaGlhdHIgUmVzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvZnVsbC10aXRs

ZT48YWJici0xPkogUHN5Y2hpYXRyIFJlczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvZnVsbC10

aXRsZT48YWJici0xPkogUHN5Y2hpYXRyIFJlczwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBh

Z2VzPjM0LTQ0PC9wYWdlcz48dm9sdW1lPjczPC92b2x1bWU+PHJlcHJpbnQtZWRpdGlvbj5OT1Qg

SU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTg3OS0xMzc5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAx

Ni9qLmpwc3ljaGlyZXMuMjAxNS4xMS4wMTM7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292

JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNw

Lm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9

ZnVsbHRleHQmYW1wO0Q9cHJlbSZhbXA7QU49MjY2Nzk3NjNodHRwOi8vc2Z4LnVjbC5hYy51ay9z

ZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyNjY3OTc2MyZhbXA7aWQ9ZG9p

OjEwLjEwMTYlMkZqLmpwc3ljaGlyZXMuMjAxNS4xMS4wMTMmYW1wO2lzc249MDAyMi0zOTU2JmFt

cDtpc2JuPSZhbXA7dm9sdW1lPTczJmFtcDtpc3N1ZT0xJmFtcDtzcGFnZT0zNCZhbXA7cGFnZXM9

MzQtNDQmYW1wO2RhdGU9MjAxNiZhbXA7dGl0bGU9Sm91cm5hbCtvZitQc3ljaGlhdHJpYytSZXNl

YXJjaCZhbXA7YXRpdGxlPUErcmFuZG9taXplZCtjb250cm9sbGVkK3N0dWR5K29mK3RoZStlZmZp

Y2FjeStvZitzaXgtbW9udGgrc3VwcGxlbWVudGF0aW9uK3dpdGgrY29uY2VudHJhdGVkK2Zpc2gr

b2lsK3JpY2graW4rb21lZ2EtMytwb2x5dW5zYXR1cmF0ZWQrZmF0dHkrYWNpZHMraW4rZmlyc3Qr

ZXBpc29kZStzY2hpem9waHJlbmlhLiZhbXA7YXVsYXN0PVBhd2VsY3p5azwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXdlbGN6eWs8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy

PjxSZWNOdW0+MTI0MjA8L1JlY051bT48RGlzcGxheVRleHQ+KDkpPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjEyNDIwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3Rh

bXA9IjE1MzAyMTYzNDEiPjEyNDIwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5QYXdlbGN6eWssIFQuPC9hdXRob3I+PGF1dGhvcj5HcmFuY293LUdyYWJrYSwgTS48L2F1

dGhvcj48YXV0aG9yPktvdGxpY2thLUFudGN6YWssIE0uPC9hdXRob3I+PGF1dGhvcj5UcmFmYWxz

a2EsIEUuPC9hdXRob3I+PGF1dGhvcj5QYXdlbGN6eWssIEEuPC9hdXRob3I+PC9hdXRob3JzPjwv

Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGF3ZWxjenlrLFRvbWFzei4gRGVwYXJ0bWVudCBv

ZiBBZmZlY3RpdmUgYW5kIFBzeWNob3RpYyBEaXNvcmRlcnMsIE1lZGljYWwgVW5pdmVyc2l0eSBv

ZiBMb2R6LCB1bC4gQ3plY2hvc2xvd2Fja2EgOC8xMCwgOTItMjE2IExvZHosIFBvbGFuZC4gRWxl

Y3Ryb25pYyBhZGRyZXNzOiB0b21hc3oucGF3ZWxjenlrQHVtZWQubG9kei5wbC4gR3JhbmNvdy1H

cmFia2EsTWFydGEuIENlbnRyYWwgVGVhY2hpbmcgSG9zcGl0YWwsIE1lZGljYWwgVW5pdmVyc2l0

eSBvZiBMb2R6LCB1bC4gUG9tb3Jza2EgMjUxLCA5Mi0yMTMgTG9keiwgUG9sYW5kLiBFbGVjdHJv

bmljIGFkZHJlc3M6IG1hcnRhZ3JhbmNvd0BnbWFpbC5jb20uIEtvdGxpY2thLUFudGN6YWssTWFn

ZGFsZW5hLiBEZXBhcnRtZW50IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywg

TWVkaWNhbCBVbml2ZXJzaXR5IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0y

MTYgTG9keiwgUG9sYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IG1hZ2RhbGVuYS5rb3RsaWNrYS1h

bnRjemFrQHVtZWQubG9kei5wbC4gVHJhZmFsc2thLEVsemJpZXRhLiBEZXBhcnRtZW50IG9mIE51

dHJpdGlvbiBIeWdpZW5lIGFuZCBFcGlkZW1pb2xvZ3ksIE1lZGljYWwgVW5pdmVyc2l0eSBvZiBM

b2R6LCB1bC4gSmFyYWN6YSA2MywgOTAtMjUxIExvZHosIFBvbGFuZC4gRWxlY3Ryb25pYyBhZGRy

ZXNzOiBlbHpiaWV0YS50cmFmYWxza2FAdW1lZC5sb2R6LnBsLiBQYXdlbGN6eWssQWduaWVzemth

LiBEZXBhcnRtZW50IG9mIEFmZmVjdGl2ZSBhbmQgUHN5Y2hvdGljIERpc29yZGVycywgTWVkaWNh

bCBVbml2ZXJzaXR5IG9mIExvZHosIHVsLiBDemVjaG9zbG93YWNrYSA4LzEwLCA5Mi0yMTYgTG9k

eiwgUG9sYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IGFnbmllc3prYS5wYXdlbGN6eWtAdW1lZC5s

b2R6LnBsPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSByYW5kb21pemVkIGNvbnRyb2xs

ZWQgc3R1ZHkgb2YgdGhlIGVmZmljYWN5IG9mIHNpeC1tb250aCBzdXBwbGVtZW50YXRpb24gd2l0

aCBjb25jZW50cmF0ZWQgZmlzaCBvaWwgcmljaCBpbiBvbWVnYS0zIHBvbHl1bnNhdHVyYXRlZCBm

YXR0eSBhY2lkcyBpbiBmaXJzdCBlcGlzb2RlIHNjaGl6b3BocmVuaWE8L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvc2Vjb25kYXJ5LXRpdGxl

PjxhbHQtdGl0bGU+SiBQc3ljaGlhdHIgUmVzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvZnVsbC10aXRs

ZT48YWJici0xPkogUHN5Y2hpYXRyIFJlczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBQc3ljaGlhdHJpYyBSZXNlYXJjaDwvZnVsbC10

aXRsZT48YWJici0xPkogUHN5Y2hpYXRyIFJlczwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBh

Z2VzPjM0LTQ0PC9wYWdlcz48dm9sdW1lPjczPC92b2x1bWU+PHJlcHJpbnQtZWRpdGlvbj5OT1Qg

SU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+

PGlzYm4+MTg3OS0xMzc5PC9pc2JuPjx3b3JrLXR5cGU+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAx

Ni9qLmpwc3ljaGlyZXMuMjAxNS4xMS4wMTM7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292

JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNw

Lm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9

ZnVsbHRleHQmYW1wO0Q9cHJlbSZhbXA7QU49MjY2Nzk3NjNodHRwOi8vc2Z4LnVjbC5hYy51ay9z

ZnhfbG9jYWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyNjY3OTc2MyZhbXA7aWQ9ZG9p

OjEwLjEwMTYlMkZqLmpwc3ljaGlyZXMuMjAxNS4xMS4wMTMmYW1wO2lzc249MDAyMi0zOTU2JmFt

cDtpc2JuPSZhbXA7dm9sdW1lPTczJmFtcDtpc3N1ZT0xJmFtcDtzcGFnZT0zNCZhbXA7cGFnZXM9

MzQtNDQmYW1wO2RhdGU9MjAxNiZhbXA7dGl0bGU9Sm91cm5hbCtvZitQc3ljaGlhdHJpYytSZXNl

YXJjaCZhbXA7YXRpdGxlPUErcmFuZG9taXplZCtjb250cm9sbGVkK3N0dWR5K29mK3RoZStlZmZp

Y2FjeStvZitzaXgtbW9udGgrc3VwcGxlbWVudGF0aW9uK3dpdGgrY29uY2VudHJhdGVkK2Zpc2gr

b2lsK3JpY2graW4rb21lZ2EtMytwb2x5dW5zYXR1cmF0ZWQrZmF0dHkrYWNpZHMraW4rZmlyc3Qr

ZXBpc29kZStzY2hpem9waHJlbmlhLiZhbXA7YXVsYXN0PVBhd2VsY3p5azwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (9)People with first episode of schizophrenia aged 16–35, PolandEPA & DHA supplement, 1.32 g/d EPA & 0.88 g/d DHALCn3 vs MUFA36 int, 35 cont0.5 yearsOmegaAD – Freund-Levi 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmV1bmQtTGV2aTwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT41MDk3PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyNyk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+NTA5NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjEyMjI5Ij41MDk3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5GcmV1bmQtTGV2aSwgWS48L2F1dGhvcj48YXV0aG9yPkJhc3VuLCBILjwvYXV0aG9yPjxh

dXRob3I+Q2VkZXJob2xtLCBULjwvYXV0aG9yPjxhdXRob3I+RmF4ZW4tSXJ2aW5nLCBHLjwvYXV0

aG9yPjxhdXRob3I+R2FybGluZCwgQS48L2F1dGhvcj48YXV0aG9yPkdydXQsIE0uPC9hdXRob3I+

PGF1dGhvcj5WZWRpbiwgSS48L2F1dGhvcj48YXV0aG9yPlBhbG1ibGFkLCBKLjwvYXV0aG9yPjxh

dXRob3I+V2FobHVuZCwgTC4gTy48L2F1dGhvcj48YXV0aG9yPkVyaWtzZG90dGVyLUpvbmhhZ2Vu

LCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZyZXVu

ZC1MZXZpLFl2b25uZS4gRGVwYXJ0bWVudCBvZiBOVlMsIFNlY3Rpb24gb2YgQ2xpbmljYWwgR2Vy

aWF0cmljcywgS2Fyb2xpbnNrYSBJbnN0aXR1dGV0IGF0IEthcm9saW5za2EgVW5pdmVyc2l0eSBI

b3NwaXRhbCBIdWRkaW5nZSwgU3RvY2tob2xtLCBTd2VkZW4uIFl2b25uZS5GcmV1bmQtTGV2aUBr

aS5zZTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk9tZWdhLTMgc3VwcGxlbWVudGF0aW9u

IGluIG1pbGQgdG8gbW9kZXJhdGUgQWx6aGVpbWVyJmFwb3M7cyBkaXNlYXNlOiBlZmZlY3RzIG9u

IG5ldXJvcHN5Y2hpYXRyaWMgc3ltcHRvbXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SW50ZXJu

YXRpb25hbCBKb3VybmFsIG9mIEdlcmlhdHJpYyBQc3ljaGlhdHJ5PC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5JbnQgSiBHZXJpYXRyIFBzeWNoaWF0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5JbnRlcm5hdGlvbmFsIEpvdXJuYWwgb2YgR2VyaWF0cmlj

IFBzeWNoaWF0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5JbnQgSiBHZXJpYXRyIFBzeWNoaWF0cnk8

L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkludGVybmF0

aW9uYWwgSm91cm5hbCBvZiBHZXJpYXRyaWMgUHN5Y2hpYXRyeTwvZnVsbC10aXRsZT48YWJici0x

PkludCBKIEdlcmlhdHIgUHN5Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjE2MS0xNjk8L3BhZ2VzPjx2b2x1bWU+MjM8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVw

cmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nIEFnZWQgKkFsemhlaW1lciBEaXNlYXNlL2R0

IFtEcnVnIFRoZXJhcHldIEFsemhlaW1lciBEaXNlYXNlL2dlIFtHZW5ldGljc10gQWx6aGVpbWVy

IERpc2Vhc2UvcHggW1BzeWNob2xvZ3ldIEFuYWx5c2lzIG9mIFZhcmlhbmNlIEFwb2xpcG9wcm90

ZWlucyBFL2dlIFtHZW5ldGljc10gKkNob2xpbmVzdGVyYXNlIEluaGliaXRvcnMvdHUgW1RoZXJh

cGV1dGljIFVzZV0gRGVwcmVzc2lvbi9kdCBbRHI8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjA4ODUtNjIzMDwvaXNibj48d29yay10eXBl

PlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH

b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNzU4MjIyNWh0dHA6Ly9zZngudWNsLmFjLnVr

L3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE3NTgyMjI1JmFtcDtpZD1k

b2k6JmFtcDtpc3NuPTA4ODUtNjIzMCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yMyZhbXA7aXNzdWU9

MiZhbXA7c3BhZ2U9MTYxJmFtcDtwYWdlcz0xNjEtOSZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1J

bnRlcm5hdGlvbmFsK0pvdXJuYWwrb2YrR2VyaWF0cmljK1BzeWNoaWF0cnkmYW1wO2F0aXRsZT1P

bWVnYS0zK3N1cHBsZW1lbnRhdGlvbitpbittaWxkK3RvK21vZGVyYXRlK0FsemhlaW1lciUyN3Mr

ZGlzZWFzZSUzQStlZmZlY3RzK29uK25ldXJvcHN5Y2hpYXRyaWMrc3ltcHRvbXMuJmFtcDthdWxh

c3Q9RnJldW5kLUxldmk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GcmV1bmQtTGV2aTwvQXV0aG9yPjxZZWFyPjIwMDg8L1ll

YXI+PFJlY051bT41MDk3PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyNyk8L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+NTA5NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw

PSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0

YW1wPSIxNTMwMjEyMjI5Ij41MDk3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5GcmV1bmQtTGV2aSwgWS48L2F1dGhvcj48YXV0aG9yPkJhc3VuLCBILjwvYXV0aG9yPjxh

dXRob3I+Q2VkZXJob2xtLCBULjwvYXV0aG9yPjxhdXRob3I+RmF4ZW4tSXJ2aW5nLCBHLjwvYXV0

aG9yPjxhdXRob3I+R2FybGluZCwgQS48L2F1dGhvcj48YXV0aG9yPkdydXQsIE0uPC9hdXRob3I+

PGF1dGhvcj5WZWRpbiwgSS48L2F1dGhvcj48YXV0aG9yPlBhbG1ibGFkLCBKLjwvYXV0aG9yPjxh

dXRob3I+V2FobHVuZCwgTC4gTy48L2F1dGhvcj48YXV0aG9yPkVyaWtzZG90dGVyLUpvbmhhZ2Vu

LCBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZyZXVu

ZC1MZXZpLFl2b25uZS4gRGVwYXJ0bWVudCBvZiBOVlMsIFNlY3Rpb24gb2YgQ2xpbmljYWwgR2Vy

aWF0cmljcywgS2Fyb2xpbnNrYSBJbnN0aXR1dGV0IGF0IEthcm9saW5za2EgVW5pdmVyc2l0eSBI

b3NwaXRhbCBIdWRkaW5nZSwgU3RvY2tob2xtLCBTd2VkZW4uIFl2b25uZS5GcmV1bmQtTGV2aUBr

aS5zZTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk9tZWdhLTMgc3VwcGxlbWVudGF0aW9u

IGluIG1pbGQgdG8gbW9kZXJhdGUgQWx6aGVpbWVyJmFwb3M7cyBkaXNlYXNlOiBlZmZlY3RzIG9u

IG5ldXJvcHN5Y2hpYXRyaWMgc3ltcHRvbXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SW50ZXJu

YXRpb25hbCBKb3VybmFsIG9mIEdlcmlhdHJpYyBQc3ljaGlhdHJ5PC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5JbnQgSiBHZXJpYXRyIFBzeWNoaWF0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5JbnRlcm5hdGlvbmFsIEpvdXJuYWwgb2YgR2VyaWF0cmlj

IFBzeWNoaWF0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5JbnQgSiBHZXJpYXRyIFBzeWNoaWF0cnk8

L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkludGVybmF0

aW9uYWwgSm91cm5hbCBvZiBHZXJpYXRyaWMgUHN5Y2hpYXRyeTwvZnVsbC10aXRsZT48YWJici0x

PkludCBKIEdlcmlhdHIgUHN5Y2hpYXRyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjE2MS0xNjk8L3BhZ2VzPjx2b2x1bWU+MjM8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVw

cmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nIEFnZWQgKkFsemhlaW1lciBEaXNlYXNlL2R0

IFtEcnVnIFRoZXJhcHldIEFsemhlaW1lciBEaXNlYXNlL2dlIFtHZW5ldGljc10gQWx6aGVpbWVy

IERpc2Vhc2UvcHggW1BzeWNob2xvZ3ldIEFuYWx5c2lzIG9mIFZhcmlhbmNlIEFwb2xpcG9wcm90

ZWlucyBFL2dlIFtHZW5ldGljc10gKkNob2xpbmVzdGVyYXNlIEluaGliaXRvcnMvdHUgW1RoZXJh

cGV1dGljIFVzZV0gRGVwcmVzc2lvbi9kdCBbRHI8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjA4ODUtNjIzMDwvaXNibj48d29yay10eXBl

PlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH

b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlk

c3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFH

RT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNzU4MjIyNWh0dHA6Ly9zZngudWNsLmFjLnVr

L3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE3NTgyMjI1JmFtcDtpZD1k

b2k6JmFtcDtpc3NuPTA4ODUtNjIzMCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yMyZhbXA7aXNzdWU9

MiZhbXA7c3BhZ2U9MTYxJmFtcDtwYWdlcz0xNjEtOSZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1J

bnRlcm5hdGlvbmFsK0pvdXJuYWwrb2YrR2VyaWF0cmljK1BzeWNoaWF0cnkmYW1wO2F0aXRsZT1P

bWVnYS0zK3N1cHBsZW1lbnRhdGlvbitpbittaWxkK3RvK21vZGVyYXRlK0FsemhlaW1lciUyN3Mr

ZGlzZWFzZSUzQStlZmZlY3RzK29uK25ldXJvcHN5Y2hpYXRyaWMrc3ltcHRvbXMuJmFtcDthdWxh

c3Q9RnJldW5kLUxldmk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (27)People with mild to moderate Alzheimer's disease, SwedenEPA & DHA supplement, 0.60 g/d EPA & 1.72 g/d DHALCn3 vs n6103 int, 101 cont0.5 yearsOMEGA – Rauch 2010PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4xMzIwMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEzMjAzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY3OTciPjEzMjAzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5SYXVjaCwgQi48L2F1dGhvcj48YXV0aG9yPlNjaGllbGUsIFIuPC9hdXRob3I+PGF1dGhvcj5T

Y2huZWlkZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5EaWxsZXIsIEYuPC9hdXRob3I+PGF1dGhvcj5W

aWN0b3IsIE4uPC9hdXRob3I+PGF1dGhvcj5Hb2hsa2UsIEguPC9hdXRob3I+PGF1dGhvcj5Hb3R0

d2lrLCBNLjwvYXV0aG9yPjxhdXRob3I+U3RlaW5iZWNrLCBHLjwvYXV0aG9yPjxhdXRob3I+RGVs

IENhc3RpbGxvLCBVLjwvYXV0aG9yPjxhdXRob3I+U2FjaywgUi48L2F1dGhvcj48YXV0aG9yPldv

cnRoLCBILjwvYXV0aG9yPjxhdXRob3I+S2F0dXMsIEguPC9hdXRob3I+PGF1dGhvcj5TcGl0emVy

LCBXLjwvYXV0aG9yPjxhdXRob3I+U2FiaW4sIEcuPC9hdXRob3I+PGF1dGhvcj5TZW5nZXMsIEou

PC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgT21lZ2EgU3R1ZHk8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5SYXVjaCxCZXJuaGFyZC4gSW5zdGl0dXQgZnVyIEhl

cnppbmZhcmt0Zm9yc2NodW5nIEx1ZHdpZ3NoYWZlbmFuIGRlciBVbml2ZXJzaXRhdCBIZWlkZWxi

ZXJnLCBHZXJtYW55LiByYXVjaEB6YXIta2FyZGlvLWx1ZHdpZ3NoYWZlbi5kZTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPk9NRUdBLCBhIHJhbmRvbWl6ZWQsIHBsYWNlYm8tY29udHJvbGxl

ZCB0cmlhbCB0byB0ZXN0IHRoZSBlZmZlY3Qgb2YgaGlnaGx5IHB1cmlmaWVkIG9tZWdhLTMgZmF0

dHkgYWNpZHMgb24gdG9wIG9mIG1vZGVybiBndWlkZWxpbmUtYWRqdXN0ZWQgdGhlcmFweSBhZnRl

ciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRp

b248L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNpcmN1bGF0aW9uPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yMTUyLTIxNTk8L3BhZ2VzPjx2b2x1bWU+MTIy

PC92b2x1bWU+PG51bWJlcj4yMTwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8

L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBDb21iaW5lZCBNb2RhbGl0

eSBUaGVyYXB5IERlYXRoLFN1ZGRlbixDYXJkaWFjL2VwIFtFcGlkZW1pb2xvZ3ldICpEZWF0aCxT

dWRkZW4sQ2FyZGlhYy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSAqRmF0dHkgQWNpZHMs

T21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVn

YS0zL2FlIFtBZHZlcnNlIEVmZmVjdHNdIEZlbWFsZSBGb2xsb3ctVXAgU3R1ZGllcyBGb29kIEhh

Yml0cyBIdW08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2Rh

dGVzPjxpc2JuPjE1MjQtNDUzOTwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEw

LjExNjEvQ0lSQ1VMQVRJT05BSEEuMTEwLjk0ODU2MjtNdWx0aWNlbnRlciBTdHVkeSBSYW5kb21p

emVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkNSZhbXA7QU49MjEwNjAwNzFodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9j

YWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMTA2MDA3MSZhbXA7aWQ9ZG9pOjEwLjEx

NjElMkZDSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyJmFtcDtpc3NuPTAwMDktNzMyMiZhbXA7aXNi

bj0mYW1wO3ZvbHVtZT0xMjImYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMTUyJmFtcDtwYWdlcz0y

MTUyLTkmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Q2lyY3VsYXRpb24mYW1wO2F0aXRsZT1PTUVH

QSUyQythK3JhbmRvbWl6ZWQlMkMrcGxhY2Viby1jb250cm9sbGVkK3RyaWFsK3RvK3Rlc3QrdGhl

K2VmZmVjdCtvZitoaWdobHkrcHVyaWZpZWQrb21lZ2EtMytmYXR0eSthY2lkcytvbit0b3Arb2Yr

bW9kZXJuK2d1aWRlbGluZS1hZGp1c3RlZCt0aGVyYXB5K2FmdGVyK215b2NhcmRpYWwraW5mYXJj

dGlvbi4mYW1wO2F1bGFzdD1SYXVjaDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYXVjaDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT4xMzIwMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEzMjAzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY3OTciPjEzMjAzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5SYXVjaCwgQi48L2F1dGhvcj48YXV0aG9yPlNjaGllbGUsIFIuPC9hdXRob3I+PGF1dGhvcj5T

Y2huZWlkZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5EaWxsZXIsIEYuPC9hdXRob3I+PGF1dGhvcj5W

aWN0b3IsIE4uPC9hdXRob3I+PGF1dGhvcj5Hb2hsa2UsIEguPC9hdXRob3I+PGF1dGhvcj5Hb3R0

d2lrLCBNLjwvYXV0aG9yPjxhdXRob3I+U3RlaW5iZWNrLCBHLjwvYXV0aG9yPjxhdXRob3I+RGVs

IENhc3RpbGxvLCBVLjwvYXV0aG9yPjxhdXRob3I+U2FjaywgUi48L2F1dGhvcj48YXV0aG9yPldv

cnRoLCBILjwvYXV0aG9yPjxhdXRob3I+S2F0dXMsIEguPC9hdXRob3I+PGF1dGhvcj5TcGl0emVy

LCBXLjwvYXV0aG9yPjxhdXRob3I+U2FiaW4sIEcuPC9hdXRob3I+PGF1dGhvcj5TZW5nZXMsIEou

PC9hdXRob3I+PGF1dGhvcj5Hcm91cCwgT21lZ2EgU3R1ZHk8L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5SYXVjaCxCZXJuaGFyZC4gSW5zdGl0dXQgZnVyIEhl

cnppbmZhcmt0Zm9yc2NodW5nIEx1ZHdpZ3NoYWZlbmFuIGRlciBVbml2ZXJzaXRhdCBIZWlkZWxi

ZXJnLCBHZXJtYW55LiByYXVjaEB6YXIta2FyZGlvLWx1ZHdpZ3NoYWZlbi5kZTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPk9NRUdBLCBhIHJhbmRvbWl6ZWQsIHBsYWNlYm8tY29udHJvbGxl

ZCB0cmlhbCB0byB0ZXN0IHRoZSBlZmZlY3Qgb2YgaGlnaGx5IHB1cmlmaWVkIG9tZWdhLTMgZmF0

dHkgYWNpZHMgb24gdG9wIG9mIG1vZGVybiBndWlkZWxpbmUtYWRqdXN0ZWQgdGhlcmFweSBhZnRl

ciBteW9jYXJkaWFsIGluZmFyY3Rpb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2lyY3VsYXRp

b248L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNpcmN1bGF0aW9uPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2lyY3VsYXRpb248L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjdWxhdGlvbjwvZnVsbC10

aXRsZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yMTUyLTIxNTk8L3BhZ2VzPjx2b2x1bWU+MTIy

PC92b2x1bWU+PG51bWJlcj4yMTwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8

L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBDb21iaW5lZCBNb2RhbGl0

eSBUaGVyYXB5IERlYXRoLFN1ZGRlbixDYXJkaWFjL2VwIFtFcGlkZW1pb2xvZ3ldICpEZWF0aCxT

dWRkZW4sQ2FyZGlhYy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSAqRmF0dHkgQWNpZHMs

T21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVn

YS0zL2FlIFtBZHZlcnNlIEVmZmVjdHNdIEZlbWFsZSBGb2xsb3ctVXAgU3R1ZGllcyBGb29kIEhh

Yml0cyBIdW08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2Rh

dGVzPjxpc2JuPjE1MjQtNDUzOTwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEw

LjExNjEvQ0lSQ1VMQVRJT05BSEEuMTEwLjk0ODU2MjtNdWx0aWNlbnRlciBTdHVkeSBSYW5kb21p

emVkIENvbnRyb2xsZWQgVHJpYWwgUmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7

dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu

Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl

eHQmYW1wO0Q9bWVkNSZhbXA7QU49MjEwNjAwNzFodHRwOi8vc2Z4LnVjbC5hYy51ay9zZnhfbG9j

YWw/c2lkPU9WSUQ6bWVkbGluZSZhbXA7aWQ9cG1pZDoyMTA2MDA3MSZhbXA7aWQ9ZG9pOjEwLjEx

NjElMkZDSVJDVUxBVElPTkFIQS4xMTAuOTQ4NTYyJmFtcDtpc3NuPTAwMDktNzMyMiZhbXA7aXNi

bj0mYW1wO3ZvbHVtZT0xMjImYW1wO2lzc3VlPTIxJmFtcDtzcGFnZT0yMTUyJmFtcDtwYWdlcz0y

MTUyLTkmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Q2lyY3VsYXRpb24mYW1wO2F0aXRsZT1PTUVH

QSUyQythK3JhbmRvbWl6ZWQlMkMrcGxhY2Viby1jb250cm9sbGVkK3RyaWFsK3RvK3Rlc3QrdGhl

K2VmZmVjdCtvZitoaWdobHkrcHVyaWZpZWQrb21lZ2EtMytmYXR0eSthY2lkcytvbit0b3Arb2Yr

bW9kZXJuK2d1aWRlbGluZS1hZGp1c3RlZCt0aGVyYXB5K2FmdGVyK215b2NhcmRpYWwraW5mYXJj

dGlvbi4mYW1wO2F1bGFzdD1SYXVjaDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (10)People who have had an acute myocardial infarction, GermanyEPA & DHA supplement, 0.46 g/d EPA & 0.39 g/d DHALCn3 vs MUFA1940 int, 1911 cont1 yearOPAL – Dangour 2010PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYW5nb3VyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

UmVjTnVtPjM1MDc8L1JlY051bT48RGlzcGxheVRleHQ+KDExKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4zNTA3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTEzNDgiPjM1MDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkRhbmdvdXIsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5BbGxlbiwgRS48L2F1dGhvcj48YXV0aG9y

PkVsYm91cm5lLCBELjwvYXV0aG9yPjxhdXRob3I+RmFzZXksIE4uPC9hdXRob3I+PGF1dGhvcj5G

bGV0Y2hlciwgQS4gRS48L2F1dGhvcj48YXV0aG9yPkhhcmR5LCBQLjwvYXV0aG9yPjxhdXRob3I+

SG9sZGVyLCBHLiBFLjwvYXV0aG9yPjxhdXRob3I+S25pZ2h0LCBSLjwvYXV0aG9yPjxhdXRob3I+

TGV0bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHMsIE0uPC9hdXRob3I+PGF1dGhvcj5V

YXV5LCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRh

bmdvdXIsQWxhbiBELiBMb25kb24gU2Nob29sIG9mIEh5Z2llbmUgYW5kIFRyb3BpY2FsIE1lZGlj

aW5lLCBVbml0ZWQgS2luZ2RvbS4gYWxhbi5kYW5nb3VyQGxzaHRtLmFjLnVrICZsdDthbGFuLmRh

bmdvdXJAbHNodG0uYWMudWsmZ3Q7PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0

IG9mIDIteSBuLTMgbG9uZy1jaGFpbiBwb2x5dW5zYXR1cmF0ZWQgZmF0dHkgYWNpZCBzdXBwbGVt

ZW50YXRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIHBlb3BsZTogYSByYW5kb21p

emVkLCBkb3VibGUtYmxpbmQsIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFtIEogQ2xpbiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2Z1

bGwtdGl0bGU+PGFiYnItMT5BbSBKIENsaW4gTnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIEFtZXJp

Y2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxh

bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51

dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnIt

Mj5UaGUgQW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4xNzI1LTE3MzI8L3BhZ2VzPjx2b2x1bWU+OTE8L3ZvbHVtZT48

bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkNvZ25pdGlvbi9kZSBbRHJ1ZyBFZmZlY3Rz

XSBDb2duaXRpb24vcGggW1BoeXNpb2xvZ3ldIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJs

aW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsg

RG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS0zL2JsIFtCbG9vZF0gRmVtYWxlIEh1bWFucyBNYWxl

IE5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0cyBQYXRpZW50IENvbXBsaWFuY2UgMCAoRmF0dHk8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE5

MzgtMzIwNzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjM5NDUvYWpjbi4y

MDA5LjI5MTIxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDQxMDA4OWh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDEwMDg5

JmFtcDtpZD1kb2k6MTAuMzk0NSUyRmFqY24uMjAwOS4yOTEyMSZhbXA7aXNzbj0wMDAyLTkxNjUm

YW1wO2lzYm49JmFtcDt2b2x1bWU9OTEmYW1wO2lzc3VlPTYmYW1wO3NwYWdlPTE3MjUmYW1wO3Bh

Z2VzPTE3MjUtMzImYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitD

bGluaWNhbCtOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2YrMi15K24tMytsb25nLWNoYWlu

K3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkK3N1cHBsZW1lbnRhdGlvbitvbitjb2duaXRpdmUr

ZnVuY3Rpb24raW4rb2xkZXIrcGVvcGxlJTNBK2ErcmFuZG9taXplZCUyQytkb3VibGUtYmxpbmQl

MkMrY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1EYW5nb3VyPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYW5nb3VyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48

UmVjTnVtPjM1MDc8L1JlY051bT48RGlzcGxheVRleHQ+KDExKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4zNTA3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTEzNDgiPjM1MDc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkRhbmdvdXIsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5BbGxlbiwgRS48L2F1dGhvcj48YXV0aG9y

PkVsYm91cm5lLCBELjwvYXV0aG9yPjxhdXRob3I+RmFzZXksIE4uPC9hdXRob3I+PGF1dGhvcj5G

bGV0Y2hlciwgQS4gRS48L2F1dGhvcj48YXV0aG9yPkhhcmR5LCBQLjwvYXV0aG9yPjxhdXRob3I+

SG9sZGVyLCBHLiBFLjwvYXV0aG9yPjxhdXRob3I+S25pZ2h0LCBSLjwvYXV0aG9yPjxhdXRob3I+

TGV0bGV5LCBMLjwvYXV0aG9yPjxhdXRob3I+UmljaGFyZHMsIE0uPC9hdXRob3I+PGF1dGhvcj5V

YXV5LCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRh

bmdvdXIsQWxhbiBELiBMb25kb24gU2Nob29sIG9mIEh5Z2llbmUgYW5kIFRyb3BpY2FsIE1lZGlj

aW5lLCBVbml0ZWQgS2luZ2RvbS4gYWxhbi5kYW5nb3VyQGxzaHRtLmFjLnVrICZsdDthbGFuLmRh

bmdvdXJAbHNodG0uYWMudWsmZ3Q7PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RWZmZWN0

IG9mIDIteSBuLTMgbG9uZy1jaGFpbiBwb2x5dW5zYXR1cmF0ZWQgZmF0dHkgYWNpZCBzdXBwbGVt

ZW50YXRpb24gb24gY29nbml0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIHBlb3BsZTogYSByYW5kb21p

emVkLCBkb3VibGUtYmxpbmQsIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0

bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFtIEogQ2xpbiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2Z1

bGwtdGl0bGU+PGFiYnItMT5BbSBKIENsaW4gTnV0cjwvYWJici0xPjxhYmJyLTI+VGhlIEFtZXJp

Y2FuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTnV0cml0aW9uPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxh

bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENsaW5pY2FsIE51

dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2xpbiBOdXRyPC9hYmJyLTE+PGFiYnIt

Mj5UaGUgQW1lcmljYW4gSm91cm5hbCBvZiBDbGluaWNhbCBOdXRyaXRpb248L2FiYnItMj48L2Fs

dC1wZXJpb2RpY2FsPjxwYWdlcz4xNzI1LTE3MzI8L3BhZ2VzPjx2b2x1bWU+OTE8L3ZvbHVtZT48

bnVtYmVyPjY8L251bWJlcj48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgKkNvZ25pdGlvbi9kZSBbRHJ1ZyBFZmZlY3Rz

XSBDb2duaXRpb24vcGggW1BoeXNpb2xvZ3ldIERpZXRhcnkgU3VwcGxlbWVudHMgRG91YmxlLUJs

aW5kIE1ldGhvZCAqRmF0dHkgQWNpZHMsT21lZ2EtMy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsg

RG9zYWdlXSBGYXR0eSBBY2lkcyxPbWVnYS0zL2JsIFtCbG9vZF0gRmVtYWxlIEh1bWFucyBNYWxl

IE5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0cyBQYXRpZW50IENvbXBsaWFuY2UgMCAoRmF0dHk8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVzPjxpc2JuPjE5

MzgtMzIwNzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjM5NDUvYWpjbi4y

MDA5LjI5MTIxO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMDQxMDA4OWh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIwNDEwMDg5

JmFtcDtpZD1kb2k6MTAuMzk0NSUyRmFqY24uMjAwOS4yOTEyMSZhbXA7aXNzbj0wMDAyLTkxNjUm

YW1wO2lzYm49JmFtcDt2b2x1bWU9OTEmYW1wO2lzc3VlPTYmYW1wO3NwYWdlPTE3MjUmYW1wO3Bh

Z2VzPTE3MjUtMzImYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitD

bGluaWNhbCtOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3Qrb2YrMi15K24tMytsb25nLWNoYWlu

K3BvbHl1bnNhdHVyYXRlZCtmYXR0eSthY2lkK3N1cHBsZW1lbnRhdGlvbitvbitjb2duaXRpdmUr

ZnVuY3Rpb24raW4rb2xkZXIrcGVvcGxlJTNBK2ErcmFuZG9taXplZCUyQytkb3VibGUtYmxpbmQl

MkMrY29udHJvbGxlZCt0cmlhbC4mYW1wO2F1bGFzdD1EYW5nb3VyPC91cmw+PC9yZWxhdGVkLXVy

bHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (11)Healthy cognitively normal adults aged 70-79, UKEPA & DHA supplement, 0.20 g/d EPA & 0.50 g/d DHALCn3 vs MUFA434 int, 433 cont1 yearPalma 2015 ADDIN EN.CITE <EndNote><Cite><Author>Palma</Author><Year>2015</Year><RecNum>19900</RecNum><DisplayText>(28)</DisplayText><record><rec-number>19900</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530355369">19900</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Palma, C.</author></authors></contributors><titles><title>Omega 3 fatty acids supplementation in Schizophrenia</title><secondary-title>European Archives of Psychiatry and Clinical Neuroscience</secondary-title></titles><periodical><full-title>European Archives of Psychiatry &amp; Clinical Neuroscience</full-title><abbr-1>Eur Arch Psychiatry Clin Neurosci</abbr-1><abbr-2>European Archives of Psychiatry and Clinical Neuroscience</abbr-2></periodical><pages>S122-S122</pages><volume>265</volume><number>Supplement 1</number><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>(28)People with schizophrenia, SpainEPA & DHA supplement, 0.84 g/d EPA & 0.47 g/d DHALCn3 vs nil30 int, 30 cont1 yearPomponi 2014PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb21wb25pPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjEyNzYxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyOSk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTI3NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFt

cD0iMTUzMDIxNjUzMiI+MTI3NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPlBvbXBvbmksIE0uPC9hdXRob3I+PGF1dGhvcj5Mb3JpYSwgRy48L2F1dGhvcj48YXV0aG9y

PlNhbHZhdGksIFMuPC9hdXRob3I+PGF1dGhvcj5EaSBCaWFzZSwgQS48L2F1dGhvcj48YXV0aG9y

PkNvbnRlLCBHLjwvYXV0aG9yPjxhdXRob3I+VmlsbGVsbGEsIEMuPC9hdXRob3I+PGF1dGhvcj5S

aWdoaW5vLCBFLjwvYXV0aG9yPjxhdXRob3I+Q2ljaWFyZWxsaSwgQy48L2F1dGhvcj48YXV0aG9y

PkJyaWEsIFAuPC9hdXRob3I+PGF1dGhvcj5MYSBUb3JyZSwgRy48L2F1dGhvcj48YXV0aG9yPlBv

bXBvbmksIE0uIEYuIEwuPC9hdXRob3I+PGF1dGhvcj5KYW5pcmksIEwuPC9hdXRob3I+PGF1dGhv

cj5CZW50aXZvZ2xpbywgQS4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz4oUG9tcG9uaSwgQ29udGUsIFZpbGxlbGxhLCBSaWdoaW5vLCBDaWNpYXJlbGxp

LCBCcmlhLCBKYW5pcmkpIEluc3RpdHV0ZSBvZiBQc3ljaGlhdHJ5LCBEZXBhcnRtZW50IG9mIEdl

cmlhdHJpY3MsIE5ldXJvc2NpZW5jZSBhbmQgT3J0aG9wYWVkaWNzLCBVbml2ZXJzaXRhIENhdHRv

bGljYSBkZWwgU2Fjcm8gQ3VvcmUgKFVDU0MpLCBSb21hLCBJdGFseSAoUG9tcG9uaSkgQ2VudHJv

IFN0dWRpIEFjaGlsbGUgZSBMaW5kYSBMb3JlbnpvbiwgVHJldmlzbywgSXRhbHkgKExvcmlhLCBC

ZW50aXZvZ2xpbykgSW5zdGl0dXRlIG9mIE5ldXJvbG9neSwgVUNTQywgUm9tYSwgSXRhbHkgKFNh

bHZhdGksIERpIEJpYXNlKSBJc3RpdHV0byBTdXBlcmlvcmUgZGkgU2FuaXRhLCBSb21hLCBJdGFs

eSAoTGEgVG9ycmUpIERlcGFydG1lbnQgb2YgUHVibGljIEhlYWx0aCBhbmQgSW5mZWN0aW91cyBE

aXNlYXNlcywgTGEgU2FwaWVuemEgVW5pdmVyc2l0eSwgUm9tYSwgSXRhbHkgKFBvbXBvbmkpIElu

c3RpdHV0ZSBvZiBCaW9jaGVtaXN0cnkgYW5kIENsaW5pY2FsIEJpb2NoZW1pc3RyeSwgVUNTQywg

Um9tYSwgSXRhbHkgTS4gUG9tcG9uaSwgSW5zdGl0dXRlIG9mIFBzeWNoaWF0cnksIERlcGFydG1l

bnQgb2YgR2VyaWF0cmljcywgTmV1cm9zY2llbmNlIGFuZCBPcnRob3BhZWRpY3MsIFVuaXZlcnNp

dGEgQ2F0dG9saWNhIGRlbCBTYWNybyBDdW9yZSAoVUNTQyksIFJvbWEsIEl0YWx5LiBFLW1haWw6

IG1hc3NpbWlsaWFub3BvbXBvbmlAYWxpY2UuaXQ8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5ESEEgZWZmZWN0cyBpbiBQYXJraW5zb24gZGlzZWFzZSBkZXByZXNzaW9uPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkJhc2FsIEdhbmdsaWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5CYXNhbCBHYW5nbGlhPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh

bD48cGFnZXM+NjEtNjY8L3BhZ2VzPjx2b2x1bWU+NDwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVy

PjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+

PGtleXdvcmQ+RGVwcmVzc2lvbiBEb2Nvc2FoZXhhZW5vaWMgYWNpZCBQYXJraW5zb24mYXBvcztz

IGRpc2Vhc2UgYWR1bHQgYW5oZWRvbmlhIGFueGlldHkgYXBhdGh5IGFydGljbGUgY2xpbmljYWwg

YXJ0aWNsZSBjbGluaWNhbCBlZmZlY3RpdmVuZXNzIGNvbnRyb2xsZWQgc3R1ZHkgZGVwcmVzc2lv

bi9kdCBbRHJ1ZyBUaGVyYXB5XSBkaXNlYXNlIGFzc29jaWF0aW9uIGRvdWJsZSBibGluZCBwcm9j

ZWR1cmUgZHJ1ZyBlZmZlY3QgZmF0dHkgYWNpZCBibG9vZCBsZXZlPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48aXNibj4yMjEwLTUzMzY8L2lzYm4+

PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYmFnYS4yMDE0LjAzLjAwNDwv

d29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3LmVsc2V2aWVyLmNv

bS93cHMvZmluZC9qb3VybmFsZGVzY3JpcHRpb24uY3dzX2hvbWUvNzI1NDIzL2Rlc2NyaXB0aW9u

I2Rlc2NyaXB0aW9uaHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMiZhbXA7QU49MjAx

NDM4MDc2NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDplbWJhc2UmYW1w

O2lkPXBtaWQ6JmFtcDtpZD1kb2k6MTAuMTAxNiUyRmouYmFnYS4yMDE0LjAzLjAwNCZhbXA7aXNz

bj0yMjEwLTUzMzYmYW1wO2lzYm49JmFtcDt2b2x1bWU9NCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9

NjEmYW1wO3BhZ2VzPTYxLTY2JmFtcDtkYXRlPTIwMTQmYW1wO3RpdGxlPUJhc2FsK0dhbmdsaWEm

YW1wO2F0aXRsZT1ESEErZWZmZWN0cytpbitQYXJraW5zb24rZGlzZWFzZStkZXByZXNzaW9uJmFt

cDthdWxhc3Q9UG9tcG9uaTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb21wb25pPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

UmVjTnVtPjEyNzYxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyOSk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTI3NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFt

cD0iMTUzMDIxNjUzMiI+MTI3NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPlBvbXBvbmksIE0uPC9hdXRob3I+PGF1dGhvcj5Mb3JpYSwgRy48L2F1dGhvcj48YXV0aG9y

PlNhbHZhdGksIFMuPC9hdXRob3I+PGF1dGhvcj5EaSBCaWFzZSwgQS48L2F1dGhvcj48YXV0aG9y

PkNvbnRlLCBHLjwvYXV0aG9yPjxhdXRob3I+VmlsbGVsbGEsIEMuPC9hdXRob3I+PGF1dGhvcj5S

aWdoaW5vLCBFLjwvYXV0aG9yPjxhdXRob3I+Q2ljaWFyZWxsaSwgQy48L2F1dGhvcj48YXV0aG9y

PkJyaWEsIFAuPC9hdXRob3I+PGF1dGhvcj5MYSBUb3JyZSwgRy48L2F1dGhvcj48YXV0aG9yPlBv

bXBvbmksIE0uIEYuIEwuPC9hdXRob3I+PGF1dGhvcj5KYW5pcmksIEwuPC9hdXRob3I+PGF1dGhv

cj5CZW50aXZvZ2xpbywgQS4gUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz4oUG9tcG9uaSwgQ29udGUsIFZpbGxlbGxhLCBSaWdoaW5vLCBDaWNpYXJlbGxp

LCBCcmlhLCBKYW5pcmkpIEluc3RpdHV0ZSBvZiBQc3ljaGlhdHJ5LCBEZXBhcnRtZW50IG9mIEdl

cmlhdHJpY3MsIE5ldXJvc2NpZW5jZSBhbmQgT3J0aG9wYWVkaWNzLCBVbml2ZXJzaXRhIENhdHRv

bGljYSBkZWwgU2Fjcm8gQ3VvcmUgKFVDU0MpLCBSb21hLCBJdGFseSAoUG9tcG9uaSkgQ2VudHJv

IFN0dWRpIEFjaGlsbGUgZSBMaW5kYSBMb3JlbnpvbiwgVHJldmlzbywgSXRhbHkgKExvcmlhLCBC

ZW50aXZvZ2xpbykgSW5zdGl0dXRlIG9mIE5ldXJvbG9neSwgVUNTQywgUm9tYSwgSXRhbHkgKFNh

bHZhdGksIERpIEJpYXNlKSBJc3RpdHV0byBTdXBlcmlvcmUgZGkgU2FuaXRhLCBSb21hLCBJdGFs

eSAoTGEgVG9ycmUpIERlcGFydG1lbnQgb2YgUHVibGljIEhlYWx0aCBhbmQgSW5mZWN0aW91cyBE

aXNlYXNlcywgTGEgU2FwaWVuemEgVW5pdmVyc2l0eSwgUm9tYSwgSXRhbHkgKFBvbXBvbmkpIElu

c3RpdHV0ZSBvZiBCaW9jaGVtaXN0cnkgYW5kIENsaW5pY2FsIEJpb2NoZW1pc3RyeSwgVUNTQywg

Um9tYSwgSXRhbHkgTS4gUG9tcG9uaSwgSW5zdGl0dXRlIG9mIFBzeWNoaWF0cnksIERlcGFydG1l

bnQgb2YgR2VyaWF0cmljcywgTmV1cm9zY2llbmNlIGFuZCBPcnRob3BhZWRpY3MsIFVuaXZlcnNp

dGEgQ2F0dG9saWNhIGRlbCBTYWNybyBDdW9yZSAoVUNTQyksIFJvbWEsIEl0YWx5LiBFLW1haWw6

IG1hc3NpbWlsaWFub3BvbXBvbmlAYWxpY2UuaXQ8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5ESEEgZWZmZWN0cyBpbiBQYXJraW5zb24gZGlzZWFzZSBkZXByZXNzaW9uPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkJhc2FsIEdhbmdsaWE8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5CYXNhbCBHYW5nbGlhPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNh

bD48cGFnZXM+NjEtNjY8L3BhZ2VzPjx2b2x1bWU+NDwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVy

PjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRpdGlvbj48a2V5d29yZHM+

PGtleXdvcmQ+RGVwcmVzc2lvbiBEb2Nvc2FoZXhhZW5vaWMgYWNpZCBQYXJraW5zb24mYXBvcztz

IGRpc2Vhc2UgYWR1bHQgYW5oZWRvbmlhIGFueGlldHkgYXBhdGh5IGFydGljbGUgY2xpbmljYWwg

YXJ0aWNsZSBjbGluaWNhbCBlZmZlY3RpdmVuZXNzIGNvbnRyb2xsZWQgc3R1ZHkgZGVwcmVzc2lv

bi9kdCBbRHJ1ZyBUaGVyYXB5XSBkaXNlYXNlIGFzc29jaWF0aW9uIGRvdWJsZSBibGluZCBwcm9j

ZWR1cmUgZHJ1ZyBlZmZlY3QgZmF0dHkgYWNpZCBibG9vZCBsZXZlPC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48aXNibj4yMjEwLTUzMzY8L2lzYm4+

PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYmFnYS4yMDE0LjAzLjAwNDwv

d29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3LmVsc2V2aWVyLmNv

bS93cHMvZmluZC9qb3VybmFsZGVzY3JpcHRpb24uY3dzX2hvbWUvNzI1NDIzL2Rlc2NyaXB0aW9u

I2Rlc2NyaXB0aW9uaHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtD

U0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQxMiZhbXA7QU49MjAx

NDM4MDc2NWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDplbWJhc2UmYW1w

O2lkPXBtaWQ6JmFtcDtpZD1kb2k6MTAuMTAxNiUyRmouYmFnYS4yMDE0LjAzLjAwNCZhbXA7aXNz

bj0yMjEwLTUzMzYmYW1wO2lzYm49JmFtcDt2b2x1bWU9NCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9

NjEmYW1wO3BhZ2VzPTYxLTY2JmFtcDtkYXRlPTIwMTQmYW1wO3RpdGxlPUJhc2FsK0dhbmdsaWEm

YW1wO2F0aXRsZT1ESEErZWZmZWN0cytpbitQYXJraW5zb24rZGlzZWFzZStkZXByZXNzaW9uJmFt

cDthdWxhc3Q9UG9tcG9uaTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA (29)Adults with mild to moderate Parkinson's disease (some with depression), ItalyEPA & DHA supplement, 0.29 g/d EPA & 0.80 g/d DHALCn3 vs n612 int, 12 cont0.5 yearsPratt 2009PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmF0dDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

Y051bT4xMjg0OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEyODQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY1ODEiPjEyODQ5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5QcmF0dCwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlJlaWZmZWwsIEouIEEuPC9hdXRob3I+PGF1

dGhvcj5FbGxlbmJvZ2VuLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+TmFjY2FyZWxsaSwgRy4gVi48

L2F1dGhvcj48YXV0aG9yPktvd2V5LCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPlByYXR0LENyYWlnIE0uIE1ldGhvZGlzdCBEZUJha2V5IEhlYXJ0

ICZhbXA7IFZhc2N1bGFyIENlbnRlciwgNjU2NSBGYW5uaW4gU3RyZWV0LCBGMTAwMSwgSG91c3Rv

biwgVFggNzcwMzAsIFVTQS4gY3ByYXR0QHRtaHMub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+RWZmaWNhY3kgYW5kIHNhZmV0eSBvZiBwcmVzY3JpcHRpb24gb21lZ2EtMy1hY2lkIGV0

aHlsIGVzdGVycyBmb3IgdGhlIHByZXZlbnRpb24gb2YgcmVjdXJyZW50IHN5bXB0b21hdGljIGF0

cmlhbCBmaWJyaWxsYXRpb246IGEgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

QW0gSGVhcnQgSjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFt

ZXJpY2FuIEhlYXJ0IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBIZWFydCBKPC9hYmJy

LTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSGVhcnQgSm91cm5hbDwvYWJici0yPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvZnVs

bC10aXRsZT48YWJici0xPkFtIEhlYXJ0IEo8L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBI

ZWFydCBKb3VybmFsPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTYzLTE2OTwvcGFn

ZXM+PHZvbHVtZT4xNTg8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1lZGl0aW9u

Pk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gKkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkF0cmlhbCBGaWJyaWxsYXRpb24v

cGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtB

ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvdHUgW1Ro

ZXJhcGV1dGljIFVzZV0gRG91YmxlLUJsaW5kIE08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjEwOTctNjc0NDwvaXNibj48d29yay10eXBl

Pmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5haGouMjAwOS4wNS4wMjQ7UmFuZG9taXplZCBD

b250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9v

dmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFt

cDtEPW1lZDUmYW1wO0FOPTE5NjE5NjkwaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3Np

ZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTk2MTk2OTAmYW1wO2lkPWRvaToxMC4xMDE2JTJG

ai5haGouMjAwOS4wNS4wMjQmYW1wO2lzc249MDAwMi04NzAzJmFtcDtpc2JuPSZhbXA7dm9sdW1l

PTE1OCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9MTYzJmFtcDtwYWdlcz0xNjMtMTY5LmUxLTMmYW1w

O2RhdGU9MjAwOSZhbXA7dGl0bGU9QW1lcmljYW4rSGVhcnQrSm91cm5hbCZhbXA7YXRpdGxlPUVm

ZmljYWN5K2FuZCtzYWZldHkrb2YrcHJlc2NyaXB0aW9uK29tZWdhLTMtYWNpZCtldGh5bCtlc3Rl

cnMrZm9yK3RoZStwcmV2ZW50aW9uK29mK3JlY3VycmVudCtzeW1wdG9tYXRpYythdHJpYWwrZmli

cmlsbGF0aW9uJTNBK2ErcHJvc3BlY3RpdmUrc3R1ZHkuJmFtcDthdWxhc3Q9UHJhdHQ8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmF0dDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl

Y051bT4xMjg0OTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMzApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEyODQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iNTJ6OTBhdzVqcnZzczVlNWUwZXZmc3M0YWF0dHRmZDVmczB0IiB0aW1lc3RhbXA9

IjE1MzAyMTY1ODEiPjEyODQ5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5QcmF0dCwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlJlaWZmZWwsIEouIEEuPC9hdXRob3I+PGF1

dGhvcj5FbGxlbmJvZ2VuLCBLLiBBLjwvYXV0aG9yPjxhdXRob3I+TmFjY2FyZWxsaSwgRy4gVi48

L2F1dGhvcj48YXV0aG9yPktvd2V5LCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPlByYXR0LENyYWlnIE0uIE1ldGhvZGlzdCBEZUJha2V5IEhlYXJ0

ICZhbXA7IFZhc2N1bGFyIENlbnRlciwgNjU2NSBGYW5uaW4gU3RyZWV0LCBGMTAwMSwgSG91c3Rv

biwgVFggNzcwMzAsIFVTQS4gY3ByYXR0QHRtaHMub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+RWZmaWNhY3kgYW5kIHNhZmV0eSBvZiBwcmVzY3JpcHRpb24gb21lZ2EtMy1hY2lkIGV0

aHlsIGVzdGVycyBmb3IgdGhlIHByZXZlbnRpb24gb2YgcmVjdXJyZW50IHN5bXB0b21hdGljIGF0

cmlhbCBmaWJyaWxsYXRpb246IGEgcHJvc3BlY3RpdmUgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

QW0gSGVhcnQgSjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFt

ZXJpY2FuIEhlYXJ0IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbSBIZWFydCBKPC9hYmJy

LTE+PGFiYnItMj5UaGUgQW1lcmljYW4gSGVhcnQgSm91cm5hbDwvYWJici0yPjwvcGVyaW9kaWNh

bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSGVhcnQgSm91cm5hbDwvZnVs

bC10aXRsZT48YWJici0xPkFtIEhlYXJ0IEo8L2FiYnItMT48YWJici0yPlRoZSBBbWVyaWNhbiBI

ZWFydCBKb3VybmFsPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTYzLTE2OTwvcGFn

ZXM+PHZvbHVtZT4xNTg8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48cmVwcmludC1lZGl0aW9u

Pk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gKkFudGktQXJy

aHl0aG1pYSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gKkF0cmlhbCBGaWJyaWxsYXRpb24v

cGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF0gRG9jb3NhaGV4YWVub2ljIEFjaWRzL2FkIFtB

ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdICpEb2Nvc2FoZXhhZW5vaWMgQWNpZHMvdHUgW1Ro

ZXJhcGV1dGljIFVzZV0gRG91YmxlLUJsaW5kIE08L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAwOTwveWVhcj48L2RhdGVzPjxpc2JuPjEwOTctNjc0NDwvaXNibj48d29yay10eXBl

Pmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai5haGouMjAwOS4wNS4wMjQ7UmFuZG9taXplZCBD

b250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dv

cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9v

dmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFt

cDtEPW1lZDUmYW1wO0FOPTE5NjE5NjkwaHR0cDovL3NmeC51Y2wuYWMudWsvc2Z4X2xvY2FsP3Np

ZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MTk2MTk2OTAmYW1wO2lkPWRvaToxMC4xMDE2JTJG

ai5haGouMjAwOS4wNS4wMjQmYW1wO2lzc249MDAwMi04NzAzJmFtcDtpc2JuPSZhbXA7dm9sdW1l

PTE1OCZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9MTYzJmFtcDtwYWdlcz0xNjMtMTY5LmUxLTMmYW1w

O2RhdGU9MjAwOSZhbXA7dGl0bGU9QW1lcmljYW4rSGVhcnQrSm91cm5hbCZhbXA7YXRpdGxlPUVm

ZmljYWN5K2FuZCtzYWZldHkrb2YrcHJlc2NyaXB0aW9uK29tZWdhLTMtYWNpZCtldGh5bCtlc3Rl

cnMrZm9yK3RoZStwcmV2ZW50aW9uK29mK3JlY3VycmVudCtzeW1wdG9tYXRpYythdHJpYWwrZmli

cmlsbGF0aW9uJTNBK2ErcHJvc3BlY3RpdmUrc3R1ZHkuJmFtcDthdWxhc3Q9UHJhdHQ8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (30)Adults with paroxysmal or persistent atrial fibrillation, USAEPA & DHA supplement, 1.86 g/d EPA & 1.5 g/d DHALCn3 vs n6332 int, 331 cont0.5 yearsPREDIMED – Estruch 2013 ADDIN EN.CITE <EndNote><Cite><Author>Estruch</Author><Year>2018</Year><RecNum>18084</RecNum><DisplayText>(35)</DisplayText><record><rec-number>18084</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530303952">18084</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Estruch, R.</author><author>Ros, E.</author><author>Salas-Salvadó, J.</author><author>Covas, M.</author><author>Corella, D.</author><author>Arós F et, a l</author></authors></contributors><titles><title>Retraction and republication: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368:1279-90</title><secondary-title>New England Journal of Medicine</secondary-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N Engl J Med</abbr-1><abbr-2>NEJM</abbr-2><abbr-3>The New England Journal of Medicine</abbr-3></periodical><pages>25-25</pages><volume>378</volume><dates><year>2018</year></dates><urls></urls></record></Cite></EndNote>(35)Men aged 55 to 80 years and women aged 60 to 80 years, free of CVD but with diabetes or at least 3 CVD risk factors, SpainDietary advice and food supplement (mixed nuts), PUFA dose unclearPUFA vs MUFA2454 int, 2543 cont5 yearsSinn 2012PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW5uPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjE0OTA5PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMik8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTQ5MDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDIxNzc3MiI+MTQ5MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlNpbm4sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWx0ZSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlN0

cmVldCwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkJ1Y2tsZXksIEouIEQuPC9hdXRob3I+PGF1dGhv

cj5Db2F0ZXMsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5QZXRrb3YsIEouPC9hdXRob3I+PGF1dGhv

cj5Ib3dlLCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPlNpbm4sTmF0YWxpZS4gU2Nob29sIG9mIEhlYWx0aCBTY2llbmNlcywgU2Fuc29tIEluc3Rp

dHV0ZSBmb3IgSGVhbHRoIFJlc2VhcmNoLCBOdXRyaXRpb25hbCBQaHlzaW9sb2d5IFJlc2VhcmNo

IENlbnRyZSwgVW5pdmVyc2l0eSBvZiBTb3V0aCBBdXN0cmFsaWEsIEdQTyBCb3ggMjQ3MSwgQWRl

bGFpZGUsIFNBIDUwMDEsIEF1c3RyYWxpYS4gbmF0YWxpZS5zaW5uQHVuaXNhLmVkdS5hdTwvYXV0

aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIGZhdHR5IGFjaWRzLCBFUEEg

di4gREhBLCBvbiBkZXByZXNzaXZlIHN5bXB0b21zLCBxdWFsaXR5IG9mIGxpZmUsIG1lbW9yeSBh

bmQgZXhlY3V0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIGFkdWx0cyB3aXRoIG1pbGQgY29nbml0aXZl

IGltcGFpcm1lbnQ6IGEgNi1tb250aCByYW5kb21pc2VkIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48

YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0x

PkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE2ODItMTY5MzwvcGFn

ZXM+PHZvbHVtZT4xMDc8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlv

bj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFn

ZWQsODAgYW5kIG92ZXIgQXVzdHJhbGlhIENvZ25pdGlvbiBEaXNvcmRlcnMvYmwgW0Jsb29kXSAq

Q29nbml0aW9uIERpc29yZGVycy9kaCBbRGlldCBUaGVyYXB5XSBDb2duaXRpb24gRGlzb3JkZXJz

L3BwIFtQaHlzaW9wYXRob2xvZ3ldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHggW1BzeWNob2xvZ3ld

IERlcHJlc3Npb24vYmwgW0Jsb29kXSAqRGVwcmVzc2lvbi9kaCBbRGlldCBUaGVyYXB5XSBEZXBy

ZXNzaW9uL3BwIFtQaHlzaW9wPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8

L3llYXI+PC9kYXRlcz48aXNibj4xNDc1LTI2NjI8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHgu

ZG9pLm9yZy8xMC4xMDE3L1MwMDA3MTE0NTExMDA0Nzg4O0NvbXBhcmF0aXZlIFN0dWR5IE11bHRp

Y2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMTkyOTgzNWh0dHA6Ly9z

ZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxOTI5

ODM1JmFtcDtpZD1kb2k6MTAuMTAxNyUyRlMwMDA3MTE0NTExMDA0Nzg4JmFtcDtpc3NuPTAwMDct

MTE0NSZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xMDcmYW1wO2lzc3VlPTExJmFtcDtzcGFnZT0xNjgy

JmFtcDtwYWdlcz0xNjgyLTkzJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUJyaXRpc2grSm91cm5h

bCtvZitOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3RzK29mK24tMytmYXR0eSthY2lkcyUyQytF

UEErdi4rREhBJTJDK29uK2RlcHJlc3NpdmUrc3ltcHRvbXMlMkMrcXVhbGl0eStvZitsaWZlJTJD

K21lbW9yeSthbmQrZXhlY3V0aXZlK2Z1bmN0aW9uK2luK29sZGVyK2FkdWx0cyt3aXRoK21pbGQr

Y29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYSs2LW1vbnRoK3JhbmRvbWlzZWQrY29udHJvbGxlZCt0

cmlhbC4mYW1wO2F1bGFzdD1TaW5uPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW5uPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

TnVtPjE0OTA5PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMik8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTQ5MDk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI1Mno5MGF3NWpydnNzNWU1ZTBldmZzczRhYXR0dGZkNWZzMHQiIHRpbWVzdGFtcD0i

MTUzMDIxNzc3MiI+MTQ5MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlNpbm4sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWx0ZSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPlN0

cmVldCwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkJ1Y2tsZXksIEouIEQuPC9hdXRob3I+PGF1dGhv

cj5Db2F0ZXMsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5QZXRrb3YsIEouPC9hdXRob3I+PGF1dGhv

cj5Ib3dlLCBQLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPlNpbm4sTmF0YWxpZS4gU2Nob29sIG9mIEhlYWx0aCBTY2llbmNlcywgU2Fuc29tIEluc3Rp

dHV0ZSBmb3IgSGVhbHRoIFJlc2VhcmNoLCBOdXRyaXRpb25hbCBQaHlzaW9sb2d5IFJlc2VhcmNo

IENlbnRyZSwgVW5pdmVyc2l0eSBvZiBTb3V0aCBBdXN0cmFsaWEsIEdQTyBCb3ggMjQ3MSwgQWRl

bGFpZGUsIFNBIDUwMDEsIEF1c3RyYWxpYS4gbmF0YWxpZS5zaW5uQHVuaXNhLmVkdS5hdTwvYXV0

aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkVmZmVjdHMgb2Ygbi0zIGZhdHR5IGFjaWRzLCBFUEEg

di4gREhBLCBvbiBkZXByZXNzaXZlIHN5bXB0b21zLCBxdWFsaXR5IG9mIGxpZmUsIG1lbW9yeSBh

bmQgZXhlY3V0aXZlIGZ1bmN0aW9uIGluIG9sZGVyIGFkdWx0cyB3aXRoIG1pbGQgY29nbml0aXZl

IGltcGFpcm1lbnQ6IGEgNi1tb250aCByYW5kb21pc2VkIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvc2Vjb25kYXJ5

LXRpdGxlPjxhbHQtdGl0bGU+QnIgSiBOdXRyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48

YWJici0xPkJyIEogTnV0cjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+QnJpdGlzaCBKb3VybmFsIG9mIE51dHJpdGlvbjwvZnVsbC10aXRsZT48YWJici0x

PkJyIEogTnV0cjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE2ODItMTY5MzwvcGFn

ZXM+PHZvbHVtZT4xMDc8L3ZvbHVtZT48bnVtYmVyPjExPC9udW1iZXI+PHJlcHJpbnQtZWRpdGlv

bj5OT1QgSU4gRklMRTwvcmVwcmludC1lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkIEFn

ZWQsODAgYW5kIG92ZXIgQXVzdHJhbGlhIENvZ25pdGlvbiBEaXNvcmRlcnMvYmwgW0Jsb29kXSAq

Q29nbml0aW9uIERpc29yZGVycy9kaCBbRGlldCBUaGVyYXB5XSBDb2duaXRpb24gRGlzb3JkZXJz

L3BwIFtQaHlzaW9wYXRob2xvZ3ldIENvZ25pdGlvbiBEaXNvcmRlcnMvcHggW1BzeWNob2xvZ3ld

IERlcHJlc3Npb24vYmwgW0Jsb29kXSAqRGVwcmVzc2lvbi9kaCBbRGlldCBUaGVyYXB5XSBEZXBy

ZXNzaW9uL3BwIFtQaHlzaW9wPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8

L3llYXI+PC9kYXRlcz48aXNibj4xNDc1LTI2NjI8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHgu

ZG9pLm9yZy8xMC4xMDE3L1MwMDA3MTE0NTExMDA0Nzg4O0NvbXBhcmF0aXZlIFN0dWR5IE11bHRp

Y2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0

LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F

V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMTkyOTgzNWh0dHA6Ly9z

ZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxOTI5

ODM1JmFtcDtpZD1kb2k6MTAuMTAxNyUyRlMwMDA3MTE0NTExMDA0Nzg4JmFtcDtpc3NuPTAwMDct

MTE0NSZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xMDcmYW1wO2lzc3VlPTExJmFtcDtzcGFnZT0xNjgy

JmFtcDtwYWdlcz0xNjgyLTkzJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUJyaXRpc2grSm91cm5h

bCtvZitOdXRyaXRpb24mYW1wO2F0aXRsZT1FZmZlY3RzK29mK24tMytmYXR0eSthY2lkcyUyQytF

UEErdi4rREhBJTJDK29uK2RlcHJlc3NpdmUrc3ltcHRvbXMlMkMrcXVhbGl0eStvZitsaWZlJTJD

K21lbW9yeSthbmQrZXhlY3V0aXZlK2Z1bmN0aW9uK2luK29sZGVyK2FkdWx0cyt3aXRoK21pbGQr

Y29nbml0aXZlK2ltcGFpcm1lbnQlM0ErYSs2LW1vbnRoK3JhbmRvbWlzZWQrY29udHJvbGxlZCt0

cmlhbC4mYW1wO2F1bGFzdD1TaW5uPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3Jk

PjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (12)Older people with mild cognitive impairment & few comorbidities, AustraliaEPA & DHA supplement, 1.67 g/d EPA & 0.16 g/d DHA or 0.4 g/d EPA & 1.55 g/d DHALCn3 vs n636 int, 18 cont0.5 yearsSUFOLOM3 – Galan 2010PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYWxhbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT41MjM2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMyk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NTIzNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIx

NTMwMjEyMzAwIj41MjM2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5H

YWxhbiwgUC48L2F1dGhvcj48YXV0aG9yPktlc3NlLUd1eW90LCBFLjwvYXV0aG9yPjxhdXRob3I+

Q3plcm5pY2hvdywgUy48L2F1dGhvcj48YXV0aG9yPkJyaWFuY29uLCBTLjwvYXV0aG9yPjxhdXRo

b3I+QmxhY2hlciwgSi48L2F1dGhvcj48YXV0aG9yPkhlcmNiZXJnLCBTLjwvYXV0aG9yPjxhdXRo

b3I+R3JvdXAsIFN1IEZvbCBPbSBDb2xsYWJvcmF0aXZlPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+R2FsYW4sUGlsYXIuIFVNUiBVNTU3IEluc2VybSwgVTEx

MjUgSW5yYSwgQ25hbSwgVW5pdmVyc2l0ZSBQYXJpcyAxMywgQ1JOSCBJZEYsIEYtOTMwMTcgQm9i

aWdueSwgRnJhbmNlLiBwLmdhbGFuQHVyZW4uc21iaC51bml2LXBhcmlzMTMuZnI8L2F1dGgtYWRk

cmVzcz48dGl0bGVzPjx0aXRsZT5FZmZlY3RzIG9mIEIgdml0YW1pbnMgYW5kIG9tZWdhIDMgZmF0

dHkgYWNpZHMgb24gY2FyZGlvdmFzY3VsYXIgZGlzZWFzZXM6IGEgcmFuZG9taXNlZCBwbGFjZWJv

IGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1KPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5CbWo8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Ccml0aXNoIE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkJyIE1l

ZCBKPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0zPjwvcGVy

aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBNZWRpY2FsIEpvdXJu

YWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBNZWQgSjwvYWJici0xPjxhYmJyLTI+Qk1KPC9hYmJy

LTI+PGFiYnItMz5CbWo8L2FiYnItMz48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz5jNjI3MzwvcGFn

ZXM+PHZvbHVtZT4zNDE8L3ZvbHVtZT48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBBbmdp

bmEsVW5zdGFibGUvZGggW0RpZXQgVGhlcmFweV0gQmlvbWFya2Vycy9ibCBbQmxvb2RdICpDYXJk

aW92YXNjdWxhciBEaXNlYXNlcy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSBEaWV0YXJ5

IFN1cHBsZW1lbnRzIERvdWJsZS1CbGluZCBNZXRob2QgKkZhdHR5IEFjaWRzLE9tZWdhLTYvYWQg

W0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmF0dHkgQWNpZHMsT21lZ2EtNi9ibCBbQmxv

b2RdIEY8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVz

Pjxpc2JuPjE3NTYtMTgzMzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEx

MzYvYm1qLmM2MjczO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtB

Tj0yMTExNTU4OWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjIxMTE1NTg5JmFtcDtpZD1kb2k6MTAuMTEzNiUyRmJtai5jNjI3MyZhbXA7

aXNzbj0wOTU5LTUzNVgmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzQxJmFtcDtpc3N1ZT0yOSZhbXA7

c3BhZ2U9YzYyNzMmYW1wO3BhZ2VzPWM2MjczJmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPUJNSiZh

bXA7YXRpdGxlPUVmZmVjdHMrb2YrQit2aXRhbWlucythbmQrb21lZ2ErMytmYXR0eSthY2lkcytv

bitjYXJkaW92YXNjdWxhcitkaXNlYXNlcyUzQSthK3JhbmRvbWlzZWQrcGxhY2Vibytjb250cm9s

bGVkK3RyaWFsLiZhbXA7YXVsYXN0PUdhbGFuPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYWxhbjwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl

Y051bT41MjM2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMyk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NTIzNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1wPSIx

NTMwMjEyMzAwIj41MjM2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5H

YWxhbiwgUC48L2F1dGhvcj48YXV0aG9yPktlc3NlLUd1eW90LCBFLjwvYXV0aG9yPjxhdXRob3I+

Q3plcm5pY2hvdywgUy48L2F1dGhvcj48YXV0aG9yPkJyaWFuY29uLCBTLjwvYXV0aG9yPjxhdXRo

b3I+QmxhY2hlciwgSi48L2F1dGhvcj48YXV0aG9yPkhlcmNiZXJnLCBTLjwvYXV0aG9yPjxhdXRo

b3I+R3JvdXAsIFN1IEZvbCBPbSBDb2xsYWJvcmF0aXZlPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+R2FsYW4sUGlsYXIuIFVNUiBVNTU3IEluc2VybSwgVTEx

MjUgSW5yYSwgQ25hbSwgVW5pdmVyc2l0ZSBQYXJpcyAxMywgQ1JOSCBJZEYsIEYtOTMwMTcgQm9i

aWdueSwgRnJhbmNlLiBwLmdhbGFuQHVyZW4uc21iaC51bml2LXBhcmlzMTMuZnI8L2F1dGgtYWRk

cmVzcz48dGl0bGVzPjx0aXRsZT5FZmZlY3RzIG9mIEIgdml0YW1pbnMgYW5kIG9tZWdhIDMgZmF0

dHkgYWNpZHMgb24gY2FyZGlvdmFzY3VsYXIgZGlzZWFzZXM6IGEgcmFuZG9taXNlZCBwbGFjZWJv

IGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1KPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5CbWo8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5Ccml0aXNoIE1lZGljYWwgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPkJyIE1l

ZCBKPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48YWJici0zPkJtajwvYWJici0zPjwvcGVy

aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJpdGlzaCBNZWRpY2FsIEpvdXJu

YWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5CciBNZWQgSjwvYWJici0xPjxhYmJyLTI+Qk1KPC9hYmJy

LTI+PGFiYnItMz5CbWo8L2FiYnItMz48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz5jNjI3MzwvcGFn

ZXM+PHZvbHVtZT4zNDE8L3ZvbHVtZT48cmVwcmludC1lZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXBy

aW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQgQWdlZCw4MCBhbmQgb3ZlciBBbmdp

bmEsVW5zdGFibGUvZGggW0RpZXQgVGhlcmFweV0gQmlvbWFya2Vycy9ibCBbQmxvb2RdICpDYXJk

aW92YXNjdWxhciBEaXNlYXNlcy9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSBEaWV0YXJ5

IFN1cHBsZW1lbnRzIERvdWJsZS1CbGluZCBNZXRob2QgKkZhdHR5IEFjaWRzLE9tZWdhLTYvYWQg

W0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV0gRmF0dHkgQWNpZHMsT21lZ2EtNi9ibCBbQmxv

b2RdIEY8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48L2RhdGVz

Pjxpc2JuPjE3NTYtMTgzMzwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEx

MzYvYm1qLmM2MjczO011bHRpY2VudGVyIFN0dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh

bCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+

PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1K

UyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtB

Tj0yMTExNTU4OWh0dHA6Ly9zZngudWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5l

JmFtcDtpZD1wbWlkOjIxMTE1NTg5JmFtcDtpZD1kb2k6MTAuMTEzNiUyRmJtai5jNjI3MyZhbXA7

aXNzbj0wOTU5LTUzNVgmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzQxJmFtcDtpc3N1ZT0yOSZhbXA7

c3BhZ2U9YzYyNzMmYW1wO3BhZ2VzPWM2MjczJmFtcDtkYXRlPTIwMTAmYW1wO3RpdGxlPUJNSiZh

bXA7YXRpdGxlPUVmZmVjdHMrb2YrQit2aXRhbWlucythbmQrb21lZ2ErMytmYXR0eSthY2lkcytv

bitjYXJkaW92YXNjdWxhcitkaXNlYXNlcyUzQSthK3JhbmRvbWlzZWQrcGxhY2Vibytjb250cm9s

bGVkK3RyaWFsLiZhbXA7YXVsYXN0PUdhbGFuPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwv

cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (13)People with a history of MI, unstable angina or ischemic stroke, FranceEPA & DHA supplement, 0.4 g/d EPA & 0.2 g/d DHALCn3 vs non-fat1248 int, 1253 cont4 yearsTajalizadekhoob 2011PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MTU2ODU8L1JlY051bT48RGlzcGxheVRleHQ+KDMxKTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNTY4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4MjE1Ij4xNTY4NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VGFqYWxpemFkZWtob29iLCBZLjwvYXV0aG9yPjxhdXRob3I+U2hhcmlmaSwg

Ri48L2F1dGhvcj48YXV0aG9yPkZha2hyemFkZWgsIEguPC9hdXRob3I+PGF1dGhvcj5NaXJhcmVm

aW4sIE0uPC9hdXRob3I+PGF1dGhvcj5HaGFkZXJwYW5haGksIE0uPC9hdXRob3I+PGF1dGhvcj5C

YWRhbWNoaXphZGUsIFouPC9hdXRob3I+PGF1dGhvcj5BemltaXBvdXIsIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGFqYWxpemFkZWtob29iLFlhc2Vy

LiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtIFJlc2VhcmNoIENlbnRlciwgVGVocmFuIFVu

aXZlcnNpdHkgb2YgTWVkaWNhbCBTY2llbmNlcywgNXRoIGZsb29yLCBEciBTaGFyZWVhdGkgSG9z

cGl0YWwsIE5vcnRoIEthcmVnYXIgQXZlbnVlLCBUZWhyYW4sIElyYW48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0IG9mIGxvdy1kb3NlIG9tZWdhIDMgZmF0dHkgYWNpZHMg

b24gdGhlIHRyZWF0bWVudCBvZiBtaWxkIHRvIG1vZGVyYXRlIGRlcHJlc3Npb24gaW4gdGhlIGVs

ZGVybHk6IGEgZG91YmxlLWJsaW5kLCByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRy

eSAmYW1wOyBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0cnkgJmFt

cDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFyY2ggUHN5

Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNoaXZlcyBv

ZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNo

aWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy

IEFyY2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBB

cmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MzktNTQ5PC9wYWdlcz48dm9sdW1lPjI2MTwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFudGlkZXBy

ZXNzaXZlIEFnZW50cy90dSBbVGhlcmFwZXV0aWMgVXNlXSAqRGVwcmVzc2lvbi9kdCBbRHJ1ZyBU

aGVyYXB5XSBEaWV0IERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBIeXBlcnNlbnNpdGl2aXR5IEZh

dHR5IEFjaWRzLE9tZWdhLTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkZhdHR5IEFjaWRzLE9tZWdh

LTMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRmVtYWxlIEZpc2ggT2lscy9hZCBbQWRtaW5pPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PC9kYXRlcz48aXNibj4xNDMz

LTg0OTE8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MwMDQwNi0w

MTEtMDE5MS05O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTMxODQ1Mmh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMzE4NDUy

JmFtcDtpZD1kb2k6MTAuMTAwNyUyRnMwMDQwNi0wMTEtMDE5MS05JmFtcDtpc3NuPTA5NDAtMTMz

NCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNjEmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTUzOSZhbXA7

cGFnZXM9NTM5LTQ5JmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUV1cm9wZWFuK0FyY2hpdmVzK29m

K1BzeWNoaWF0cnkrJTI2K0NsaW5pY2FsK05ldXJvc2NpZW5jZSZhbXA7YXRpdGxlPVRoZStlZmZl

Y3Qrb2YrbG93LWRvc2Urb21lZ2ErMytmYXR0eSthY2lkcytvbit0aGUrdHJlYXRtZW50K29mK21p

bGQrdG8rbW9kZXJhdGUrZGVwcmVzc2lvbitpbit0aGUrZWxkZXJseSUzQSthK2RvdWJsZS1ibGlu

ZCUyQytyYW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCtzdHVkeS4mYW1wO2F1bGFzdD1U

YWphbGl6YWRla2hvb2I8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYWphbGl6YWRla2hvb2I8L0F1dGhvcj48WWVhcj4yMDEx

PC9ZZWFyPjxSZWNOdW0+MTU2ODU8L1JlY051bT48RGlzcGxheVRleHQ+KDMxKTwvRGlzcGxheVRl

eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNTY4NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIg

dGltZXN0YW1wPSIxNTMwMjE4MjE1Ij4xNTY4NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw

ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo

b3JzPjxhdXRob3I+VGFqYWxpemFkZWtob29iLCBZLjwvYXV0aG9yPjxhdXRob3I+U2hhcmlmaSwg

Ri48L2F1dGhvcj48YXV0aG9yPkZha2hyemFkZWgsIEguPC9hdXRob3I+PGF1dGhvcj5NaXJhcmVm

aW4sIE0uPC9hdXRob3I+PGF1dGhvcj5HaGFkZXJwYW5haGksIE0uPC9hdXRob3I+PGF1dGhvcj5C

YWRhbWNoaXphZGUsIFouPC9hdXRob3I+PGF1dGhvcj5BemltaXBvdXIsIFMuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VGFqYWxpemFkZWtob29iLFlhc2Vy

LiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtIFJlc2VhcmNoIENlbnRlciwgVGVocmFuIFVu

aXZlcnNpdHkgb2YgTWVkaWNhbCBTY2llbmNlcywgNXRoIGZsb29yLCBEciBTaGFyZWVhdGkgSG9z

cGl0YWwsIE5vcnRoIEthcmVnYXIgQXZlbnVlLCBUZWhyYW4sIElyYW48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5UaGUgZWZmZWN0IG9mIGxvdy1kb3NlIG9tZWdhIDMgZmF0dHkgYWNpZHMg

b24gdGhlIHRyZWF0bWVudCBvZiBtaWxkIHRvIG1vZGVyYXRlIGRlcHJlc3Npb24gaW4gdGhlIGVs

ZGVybHk6IGEgZG91YmxlLWJsaW5kLCByYW5kb21pemVkLCBwbGFjZWJvLWNvbnRyb2xsZWQgc3R1

ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gQXJjaGl2ZXMgb2YgUHN5Y2hpYXRy

eSAmYW1wOyBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl

PkV1ciBBcmNoIFBzeWNoaWF0cnkgQ2xpbiBOZXVyb3NjaTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNoaWF0cnkgJmFt

cDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyIEFyY2ggUHN5

Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBBcmNoaXZlcyBv

ZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48L3BlcmlvZGlj

YWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEFyY2hpdmVzIG9mIFBzeWNo

aWF0cnkgJmFtcDsgQ2xpbmljYWwgTmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy

IEFyY2ggUHN5Y2hpYXRyeSBDbGluIE5ldXJvc2NpPC9hYmJyLTE+PGFiYnItMj5FdXJvcGVhbiBB

cmNoaXZlcyBvZiBQc3ljaGlhdHJ5IGFuZCBDbGluaWNhbCBOZXVyb3NjaWVuY2U8L2FiYnItMj48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MzktNTQ5PC9wYWdlcz48dm9sdW1lPjI2MTwvdm9sdW1l

PjxudW1iZXI+ODwvbnVtYmVyPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQt

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZCBBZ2VkLDgwIGFuZCBvdmVyIEFudGlkZXBy

ZXNzaXZlIEFnZW50cy90dSBbVGhlcmFwZXV0aWMgVXNlXSAqRGVwcmVzc2lvbi9kdCBbRHJ1ZyBU

aGVyYXB5XSBEaWV0IERvdWJsZS1CbGluZCBNZXRob2QgRHJ1ZyBIeXBlcnNlbnNpdGl2aXR5IEZh

dHR5IEFjaWRzLE9tZWdhLTMvYWUgW0FkdmVyc2UgRWZmZWN0c10gKkZhdHR5IEFjaWRzLE9tZWdh

LTMvdHUgW1RoZXJhcGV1dGljIFVzZV0gRmVtYWxlIEZpc2ggT2lscy9hZCBbQWRtaW5pPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PC9kYXRlcz48aXNibj4xNDMz

LTg0OTE8L2lzYm4+PHdvcmstdHlwZT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MwMDQwNi0w

MTEtMDE5MS05O1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBO

b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0

dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9

TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0yMTMxODQ1Mmh0dHA6Ly9zZngu

dWNsLmFjLnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjIxMzE4NDUy

JmFtcDtpZD1kb2k6MTAuMTAwNyUyRnMwMDQwNi0wMTEtMDE5MS05JmFtcDtpc3NuPTA5NDAtMTMz

NCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNjEmYW1wO2lzc3VlPTgmYW1wO3NwYWdlPTUzOSZhbXA7

cGFnZXM9NTM5LTQ5JmFtcDtkYXRlPTIwMTEmYW1wO3RpdGxlPUV1cm9wZWFuK0FyY2hpdmVzK29m

K1BzeWNoaWF0cnkrJTI2K0NsaW5pY2FsK05ldXJvc2NpZW5jZSZhbXA7YXRpdGxlPVRoZStlZmZl

Y3Qrb2YrbG93LWRvc2Urb21lZ2ErMytmYXR0eSthY2lkcytvbit0aGUrdHJlYXRtZW50K29mK21p

bGQrdG8rbW9kZXJhdGUrZGVwcmVzc2lvbitpbit0aGUrZWxkZXJseSUzQSthK2RvdWJsZS1ibGlu

ZCUyQytyYW5kb21pemVkJTJDK3BsYWNlYm8tY29udHJvbGxlZCtzdHVkeS4mYW1wO2F1bGFzdD1U

YWphbGl6YWRla2hvb2I8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (31)Elderly poor people with mild or moderate depression, IranEPA & DHA supplement, 0.18 g/d EPA & 0.12 g/d DHALCn3 vs mixed fat33 int, 33 cont0.5 yearsTHIS DIET – Tuttle 2008PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXR0bGU8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MTYyODc8L1JlY051bT48RGlzcGxheVRleHQ+KDMyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE4NTQ5Ij4xNjI4Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+VHV0dGxlLCBLLiBSLjwvYXV0aG9yPjxhdXRob3I+U2h1bGVyLCBMLiBBLjwvYXV0aG9yPjxh

dXRob3I+UGFja2FyZCwgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1pbHRvbiwgSi4gRS48L2F1dGhv

cj48YXV0aG9yPkRhcmF0aGEsIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5CaWJ1cywgRC4gTS48L2F1

dGhvcj48YXV0aG9yPlNob3J0LCBSLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlR1dHRsZSxLYXRoZXJpbmUgUi4gVGhlIEhlYXJ0IEluc3RpdHV0ZSBv

ZiBTcG9rYW5lLCBTYWNyZWQgSGVhcnQgTWVkaWNhbCBDZW50ZXIsIFNwb2thbmUsIFdhc2hpbmd0

b24sIFVTQS4ga3R1dHRsZUBzaG1jLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNv

bXBhcmlzb24gb2YgbG93LWZhdCB2ZXJzdXMgTWVkaXRlcnJhbmVhbi1zdHlsZSBkaWV0YXJ5IGlu

dGVydmVudGlvbiBhZnRlciBmaXJzdCBteW9jYXJkaWFsIGluZmFyY3Rpb24gKGZyb20gVGhlIEhl

YXJ0IEluc3RpdHV0ZSBvZiBTcG9rYW5lIERpZXQgSW50ZXJ2ZW50aW9uIGFuZCBFdmFsdWF0aW9u

IFRyaWFsKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2FyZGlvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2Fy

ZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwvYWJici0xPjxhYmJyLTI+

VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0yPjxhYmJyLTM+VGhlIGFt

ZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+QW0gSiBDYXJkaW9sPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4g

Sm91cm5hbCBvZiBDYXJkaW9sb2d5PC9hYmJyLTI+PGFiYnItMz5UaGUgYW1lcmljYW4gam91cm5h

bCBvZiBjYXJkaW9sb2d5PC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTUyMy0xNTMw

PC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNv

bmZpZGVuY2UgSW50ZXJ2YWxzICpEaWV0LEZhdC1SZXN0cmljdGVkL210IFtNZXRob2RzXSAqRGll

dCxNZWRpdGVycmFuZWFuIERpc2Vhc2UtRnJlZSBTdXJ2aXZhbCBGZW1hbGUgRm9sbG93LVVwIFN0

dWRpZXMgSHVtYW5zIE1hbGUgTWlkZGxlIEFnZWQgKk15b2NhcmRpYWwgSW5mYXJjdGlvbi9kaCBb

RGlldCBUaGVyYXB5XSBNeW9jYXJkaWFsIEluZmFyY3Rpb24vZXAgW0VwaWRlbWlvbG9neV0gT2Rk

cyBSYXRpbyBSZXRyb3NwZWN0aXZlIFM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAwMDItOTE0OTwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5hbWpjYXJkLjIwMDguMDEuMDM4O0NvbXBhcmF0aXZlIFN0

dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODQ4OTkyN2h0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NDg5OTI3JmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouYW1qY2FyZC4yMDA4LjAxLjAzOCZhbXA7aXNzbj0wMDAyLTkxNDkm

YW1wO2lzYm49JmFtcDt2b2x1bWU9MTAxJmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9MTUyMyZhbXA7

cGFnZXM9MTUyMy0zMCZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29m

K0NhcmRpb2xvZ3kmYW1wO2F0aXRsZT1Db21wYXJpc29uK29mK2xvdy1mYXQrdmVyc3VzK01lZGl0

ZXJyYW5lYW4tc3R5bGUrZGlldGFyeStpbnRlcnZlbnRpb24rYWZ0ZXIrZmlyc3QrbXlvY2FyZGlh

bCtpbmZhcmN0aW9uKyUyOGZyb20rVGhlK0hlYXJ0K0luc3RpdHV0ZStvZitTcG9rYW5lK0RpZXQr

SW50ZXJ2ZW50aW9uK2FuZCtFdmFsdWF0aW9uK1RyaWFsJTI5LiZhbXA7YXVsYXN0PVR1dHRsZTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXR0bGU8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS

ZWNOdW0+MTYyODc8L1JlY051bT48RGlzcGxheVRleHQ+KDMyKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjE4NTQ5Ij4xNjI4Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK

b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo

b3I+VHV0dGxlLCBLLiBSLjwvYXV0aG9yPjxhdXRob3I+U2h1bGVyLCBMLiBBLjwvYXV0aG9yPjxh

dXRob3I+UGFja2FyZCwgRC4gUC48L2F1dGhvcj48YXV0aG9yPk1pbHRvbiwgSi4gRS48L2F1dGhv

cj48YXV0aG9yPkRhcmF0aGEsIEsuIEIuPC9hdXRob3I+PGF1dGhvcj5CaWJ1cywgRC4gTS48L2F1

dGhvcj48YXV0aG9yPlNob3J0LCBSLiBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPlR1dHRsZSxLYXRoZXJpbmUgUi4gVGhlIEhlYXJ0IEluc3RpdHV0ZSBv

ZiBTcG9rYW5lLCBTYWNyZWQgSGVhcnQgTWVkaWNhbCBDZW50ZXIsIFNwb2thbmUsIFdhc2hpbmd0

b24sIFVTQS4ga3R1dHRsZUBzaG1jLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNv

bXBhcmlzb24gb2YgbG93LWZhdCB2ZXJzdXMgTWVkaXRlcnJhbmVhbi1zdHlsZSBkaWV0YXJ5IGlu

dGVydmVudGlvbiBhZnRlciBmaXJzdCBteW9jYXJkaWFsIGluZmFyY3Rpb24gKGZyb20gVGhlIEhl

YXJ0IEluc3RpdHV0ZSBvZiBTcG9rYW5lIERpZXQgSW50ZXJ2ZW50aW9uIGFuZCBFdmFsdWF0aW9u

IFRyaWFsKTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5BbWVyaWNhbiBKb3VybmFsIG9mIENhcmRp

b2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFtIEogQ2FyZGlvbDwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgQ2Fy

ZGlvbG9neTwvZnVsbC10aXRsZT48YWJici0xPkFtIEogQ2FyZGlvbDwvYWJici0xPjxhYmJyLTI+

VGhlIEFtZXJpY2FuIEpvdXJuYWwgb2YgQ2FyZGlvbG9neTwvYWJici0yPjxhYmJyLTM+VGhlIGFt

ZXJpY2FuIGpvdXJuYWwgb2YgY2FyZGlvbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBDYXJkaW9sb2d5PC9mdWxs

LXRpdGxlPjxhYmJyLTE+QW0gSiBDYXJkaW9sPC9hYmJyLTE+PGFiYnItMj5UaGUgQW1lcmljYW4g

Sm91cm5hbCBvZiBDYXJkaW9sb2d5PC9hYmJyLTI+PGFiYnItMz5UaGUgYW1lcmljYW4gam91cm5h

bCBvZiBjYXJkaW9sb2d5PC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTUyMy0xNTMw

PC9wYWdlcz48dm9sdW1lPjEwMTwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48cmVwcmludC1l

ZGl0aW9uPk5PVCBJTiBGSUxFPC9yZXByaW50LWVkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNv

bmZpZGVuY2UgSW50ZXJ2YWxzICpEaWV0LEZhdC1SZXN0cmljdGVkL210IFtNZXRob2RzXSAqRGll

dCxNZWRpdGVycmFuZWFuIERpc2Vhc2UtRnJlZSBTdXJ2aXZhbCBGZW1hbGUgRm9sbG93LVVwIFN0

dWRpZXMgSHVtYW5zIE1hbGUgTWlkZGxlIEFnZWQgKk15b2NhcmRpYWwgSW5mYXJjdGlvbi9kaCBb

RGlldCBUaGVyYXB5XSBNeW9jYXJkaWFsIEluZmFyY3Rpb24vZXAgW0VwaWRlbWlvbG9neV0gT2Rk

cyBSYXRpbyBSZXRyb3NwZWN0aXZlIFM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAwODwveWVhcj48L2RhdGVzPjxpc2JuPjAwMDItOTE0OTwvaXNibj48d29yay10eXBlPmh0dHA6

Ly9keC5kb2kub3JnLzEwLjEwMTYvai5hbWpjYXJkLjIwMDguMDEuMDM4O0NvbXBhcmF0aXZlIFN0

dWR5IFJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCBSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5T

LiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v

dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7

UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODQ4OTkyN2h0dHA6Ly9zZngudWNsLmFj

LnVrL3NmeF9sb2NhbD9zaWQ9T1ZJRDptZWRsaW5lJmFtcDtpZD1wbWlkOjE4NDg5OTI3JmFtcDtp

ZD1kb2k6MTAuMTAxNiUyRmouYW1qY2FyZC4yMDA4LjAxLjAzOCZhbXA7aXNzbj0wMDAyLTkxNDkm

YW1wO2lzYm49JmFtcDt2b2x1bWU9MTAxJmFtcDtpc3N1ZT0xMSZhbXA7c3BhZ2U9MTUyMyZhbXA7

cGFnZXM9MTUyMy0zMCZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1BbWVyaWNhbitKb3VybmFsK29m

K0NhcmRpb2xvZ3kmYW1wO2F0aXRsZT1Db21wYXJpc29uK29mK2xvdy1mYXQrdmVyc3VzK01lZGl0

ZXJyYW5lYW4tc3R5bGUrZGlldGFyeStpbnRlcnZlbnRpb24rYWZ0ZXIrZmlyc3QrbXlvY2FyZGlh

bCtpbmZhcmN0aW9uKyUyOGZyb20rVGhlK0hlYXJ0K0luc3RpdHV0ZStvZitTcG9rYW5lK0RpZXQr

SW50ZXJ2ZW50aW9uK2FuZCtFdmFsdWF0aW9uK1RyaWFsJTI5LiZhbXA7YXVsYXN0PVR1dHRsZTwv

dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (32)Survivors of recent first myocardial infarction, USALCn3 dietary advice, dose unclear LCn3 vs mixed fat51 int, 50 cont2 yearsTREND-HD 2008 ADDIN EN.CITE <EndNote><Cite><Author>Huntington Study</Author><Year>2008</Year><RecNum>7143</RecNum><DisplayText>(33)</DisplayText><record><rec-number>7143</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530213368">7143</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Huntington Study Group,</author></authors></contributors><titles><title>Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study</title><secondary-title>Archives of Neurology</secondary-title><alt-title>Arch Neurol</alt-title></titles><periodical><full-title>Archives of Neurology</full-title><abbr-1>Arch Neurol</abbr-1></periodical><alt-periodical><full-title>Archives of Neurology</full-title><abbr-1>Arch Neurol</abbr-1></alt-periodical><pages>1582-1589</pages><volume>65</volume><number>12</number><reprint-edition>NOT IN FILE</reprint-edition><keywords><keyword>Adult Analysis of Variance Canada Double-Blind Method *Eicosapentaenoic Acid/aa [Analogs &amp; Derivatives] Eicosapentaenoic Acid/tu [Therapeutic Use] Female Follow-Up Studies Humans *Huntington Disease/dt [Drug Therapy] Huntington Disease/ge [Genetics] *Hu</keyword></keywords><dates><year>2008</year></dates><isbn>1538-3687</isbn><work-type> Trial Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov&apos;t</work-type><urls><related-urls><url>;(33)People with Huntington's disease, USA & CanadaEPA supplement, 0.95 g/d EPALCn3 vs non-fat158 int, 158 cont0.5 yearsSupplementary Table 2. High vs low long-chain omega 3 (primary outcomes)Outcome (test for subgroup differences)SA or SubgroupStudiesParticipantsEffect Estimate (Risk Ratio, M-H, Random, 95% CI)*I2, %Risk of depression symptomsMain13265281.01 [0.92, 1.10]0Summary risk of bias (SA)6246181.05 [0.90, 1.22]33Fixed effects (SA)13265281.02 [0.93, 1.12](Risk Ratio, M-H, Fixed, 95% CI)0Compliance (SA)572101.16 [0.99, 1.36]0Larger trials (≥100 randomised, SA)12264361.01 [0.92, 1.10]0Intervention type, subgrouping (p=0.68)Dietary advice11014.90 [0.24, 99.66]-Supplemental foods140680.98 [0.59, 1.63]-?Supplement or capsule10221541.00 [0.92, 1.10]0?Any combination12052.91 [0.12, 70.71]-Replacement, subgrouping (p=0.10)n3 vs SFA00Not estimable-n3 vs MUFA5224561.16 [0.99, 1.36]0n3 vs n627550.99 [0.10, 9.43]0n3 vs non-fat, nil or low n3633170.94 [0.84, 1.05]0Dose, subgroup (p=0.68)LCn3 ≤150mg/d00Not estimable-LCn3 >150 to ≤250mg/d00Not estimable-LCn3 >250 to ≤400mg/d140680.98 [0.59, 1.63]-LCn3 >400 to ≤2400mg/d10216961.00 [0.92, 1.10]0LCn3 >2.4 to ≤4.4g/d16632.99 [0.12, 73.16]-LCn3 >4.4g/d00Not estimable-Duration, subgroup (p=0.12)Duration 6 to <12 months413611.15 [0.63, 2.11]0Duration 12 to <24 months433311.18 [1.00, 1.40]0Duration 24 to <48 months343741.05 [0.64, 1.73]0Duration ≥48months2174620.93 [0.83, 1.04]0Depression risk, subgroup (p=0.03)Previous or current depression00Not estimable-Other serious illness10252780.97 [0.88, 1.07]0Healthy312501.35 [1.02, 1.79]0Antidepressant use, subgroupantidepressants used00Not estimable-no antidepressant use13265281.01 [0.92, 1.10]0Depression severity (participants have depression at baseline)Main, assessed using GDS (Geriatric Depression Score)161-0.94 [-2.27, 0.39]MD (IV, Random, 95% CI)-Low summary risk of bias (SA)00Not estimable-Fixed effects (SA)161-0.94 [-2.27, 0.39]MD (IV, Random, 95% CI)-Compliance (SA)161-0.94 [-2.27, 0.39]MD (IV, Random, 95% CI)-Larger trials (≥100 randomised, SA)00Not estimable-Depression symptoms (in those without depression at baseline)main 1599080.01 [-0.06, 0.07]SMD (IV, Random, 95% CI)46Low summary risk of bias (SA)680440.00 [-0.08, 0.08]SMD (IV, Random, 95% CI)62Fixed effects (SA)1599080.02 [-0.02, 0.06]SMD (IV, Fixed, 95% CI)46Compliance (SA)117832-0.01 [-0.10, 0.07]SMD (IV, Random, 95% CI)56Larger trials (≥100 randomised, SA)1096970.03 [-0.01, 0.07]SMD (IV, Random, 95% CI)0Assessment scale(p=0.02 in SMD analysis)Note: all available studies used for each subgroupGDS (Geriatric Depression Scale)783070.03 [-0.10, 0.16]MD (IV, Random, 95% CI)35MADRS (Montgomery–?sberg Depression Rating Scale)3698-0.12 [-0.61, 0.37]MD (IV, Random, 95% CI)0HAM-D (Hamilton Depression Scale) 124-2.70 [-6.34, 0.94]MD (IV, Random, 95% CI)-HADS (Hospital Anxiety & Depression Scale); depression subscore 14490.30 [-0.21, 0.81]MD (IV, Random, 95% CI)-GHQ (General Health Questionnaire); depression subscore12180.03 [-0.26, 0.32]MD (IV, Random, 95% CI)-SDS (Self-rating Depression Scale) 148-3.96 [-7.85, -0.07]MD (IV, Random, 95% CI)-CDS (Calgary Depression Scale for Schizophrenia) 171-1.58 [-2.66, -0.50]MD (IV, Random, 95% CI)-Derogatis tool 13921.55 [-0.42, 3.52]MD (IV, Random, 95% CI)-Intervention type, subgroup (p=0.28)?Dietary advice00Not estimable-Supplemental foods24116-0.03 [-0.15, 0.08]SMD (IV, Random, 95% CI)58Supplement or capsule1254000.00 [-0.08, 0.09]SMD (IV, Random, 95% CI)43Any combination13920.16 [-0.04, 0.35]SMD (IV, Random, 95% CI)-Replacement, subgrouping (p=0.15)n3 vs SFA00Not estimable-n3 vs MUFA54704-0.05 [-0.17, 0.07]SMD (IV, Random, 95% CI)61n3 vs n661152-0.09 [-0.30, 0.13]SMD (IV, Random, 95% CI)56n3 vs non-fat, nil or low n3440520.06 [0.00, 0.12]SMD (IV, Random, 95% CI)0Dose, subgrouping (p=0.81)LCn3 ≤150mg/d00Not estimableSMD (IV, Random, 95% CI)-LCn3 >150 to ≤250mg/d00Not estimableSMD (IV, Random, 95% CI)-LCn3 >250 to ≤400mg/d14068-0.01 [-0.08, 0.06]SMD (IV, Random, 95% CI)-LCn3 >400 to ≤2400mg/d1458400.00 [-0.08, 0.09]SMD (IV, Random, 95% CI)48LCn3 >2.4 to ≤4.4g/d00Not estimable-LCn3 >4.4g/d00Not estimable-Duration, subgrouping (p=0.02)Duration 6 to <12months81481-0.11 [-0.28, 0.07]SMD (IV, Random, 95% CI)58Duration 12 to <24 months283-0.51 [-0.95, -0.06]SMD (IV, Random, 95% CI)0Duration 24 to <48months359520.01 [-0.04, 0.06]SMD (IV, Random, 95% CI)0Duration ≥48months223920.08 [0.00, 0.16]SMD (IV, Random, 95% CI)0Depression risk, subgrouping (p=0.36)Previous or current depression161-0.35 [-0.86, 0.15]SMD (IV, Random, 95% CI)-Other serious illness1190770.01 [-0.06, 0.07]SMD (IV, Random, 95% CI)47Healthy4831-0.05 [-0.30, 0.21]SMD (IV, Random, 95% CI)55Antidepressant use, subgroupingantidepressants used00Not estimable-no antidepressants used1599080.01 [-0.06, 0.07]SMD (IV, Random, 95% CI)46Depression remission50% reduction HAM-D 1248.00 [1.17, 54.50]SMD (IV, Random, 95% CI)-Summary risk of bias (SA)00Not estimable-Compliance (SA)00Not estimable-Larger trials (≥100 randomised, SA)00Not estimable-Risk of anxiety symptomsMain1154801.00 [0.32, 3.10]-Low summary risk of bias (SA)1154801.00 [0.32, 3.10]-Fixed effects (SA)1154801.00 [0.32, 3.10]-Compliance (SA)00Not estimable-Larger trials (≥100 randomised, SA)1154801.00 [0.32, 3.10]-Anxiety remission50% reduction00Not estimable-Anxiety severity (participants have anxiety at baseline)00Not estimable-Anxiety symptoms (participants without anxiety at baseline)Main513780.15 [0.05, 0.26]SMD (IV, Random, 95% CI)0Summary risk of bias (SA)00Not estimable-Fixed effects (SA)513780.15 [0.05, 0.26]SMD (IV, Fixed, 95% CI)0Compliance (SA)39620.14 [0.01, 0.27]SMD (IV, Random, 95% CI)0Larger trials (≥100 randomised, SA)413540.16 [0.05, 0.27]SMD (IV, Random, 95% CI)0Assessment scale(p=0.72 in SMD analysis)HARS (Hamilton Anxiety Rating Scale)124-1.20 [-5.58, 3.18] MD (IV, Random, 95% CI)-HADS (Hospital Anxiety & Depression Scale) -Anxiety27440.43 [0.06, 0.79]MD (IV, Random, 95% CI)0GHQ (General Health Questionnaire) - Anxiety12180.24 [-0.55, 1.03]MD (IV, Random, 95% CI)-Derogatis Stress Profile13921.94 [0.04, 3.84]MD (IV, Random, 95% CI)-Supplementary Table 3: GRADE assessment: Summary of findings for effects of long-chain omega-3 (LCn3) on depression and anxietyPatient or population: People at any baseline risk of depression and anxiety Setting: Trials of at least 6 months duration of LCn3 in any country or context Intervention: Higher LCn3 intakeComparison: lower LCn3 intake OutcomesAnticipated absolute effects* (95% CI) Relative effect(95% CI) № of participants (studies) Certainty of the evidence(GRADE) CommentsRisk with low LCn3 (primary outcomes)Risk with High LCn3Risk of depression symptoms51 per 1,000 51 per 1,000(47 to 56) RR 1.01(0.92 to 1.10) 26528(13 RCTs) ????MODERATE a,b,c,d,eIncreasing LCn3 probably has little or no effect on depression diagnosis. Downgraded once for imprecision. Depression severity in those with depression at baseline assessed with: GDS (Geriatric Depression Scale) The mean depression severity in those with depression at baseline was 7.2 GDS score The mean depression severity in those with depression at baseline in the intervention group was 0.94 GDS score lower (2.27 lower to 0.39 higher) - 61(1 RCT) ????VERY LOW f,g,hThe effect of increasing LCn3 on depression severity is unclear as the evidence is of very low quality. Downgraded once each for risk of bias, indirectness and imprecision. Depression remissionassessed with: 50% reduction in HAM-D 83 per 1,000 667 per 1,000(97 to 1,000) RR 8.00(1.17 to 54.50) 24(1 RCT) ????VERY LOW i,j,kThe effect of increasing LCn3 on risk of remission in depression is unclear as the evidence is of very low quality. Downgraded once for risk of bias and twice for indirectness. Depression symptoms (in those without depression at baseline)- - - 9908(15 RCTs) ????MODERATE b,c,l,m,nIncreasing LCn3 probably has little or no effect on depression symptoms in people without depression at baseline. Downgraded once for publication bias. Risk of anxiety symptoms1 per 1,000 1 per 1,000(0 to 2) RR 1.00(0.32 to 3.10) 15480(1 RCT) ????VERY LOW o,p,qThe effect of increasing LCn3 on anxiety incidence is unclear as the evidence is of very low quality. Downgraded once for indirectness and twice for imprecision. Anxiety severity (in those with anxiety at baseline) Not pooled Not pooled not pooled(0 RCTs) - We found no studies that assessed effects of LCn3 on severity of anxiety in those with anxiety at baseline. Anxiety remission (50% reduction) not pooled not pooled not pooled (0 RCTs) - We found no studies that assessed effects of LCn3 on anxiety remission. Anxiety symptoms (in those without anxiety at baseline) - - - 1378(5 RCTs) ????MODERATE b,r,s,tIncreasing LCn3 probably has little or no effect on anxiety symptoms in those without anxiety at baseline. Downgraded once for risk of bias. *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; MD: Mean difference; SMD: Standardised mean difference GRADE Working Group grades of evidenceHigh certainty: We are very confident that the true effect lies close to that of the estimate of the effectModerate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially differentLow certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effectVery low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect Explanationsa. Risk of bias: Main analysis and most sensitivity analyses suggest little or no effect, but limiting to trials at low risk of compliance problems suggests increased risk of depression with increased LCn3. Not downgraded. b. Inconsistency: I2 <50%, not downgraded. c. Indirectness: men and women with a variety of baseline health conditions included, from several regions of the world. Not downgraded d. Imprecision: 95% confidence intervals include increased risk of depression with more LCn3. Downgraded once. e. Publication bias: funnel plot appears symmetrical, we are not aware of missing data. Not downgraded f. Risk of bias: the single study was not at low summary risk of bias. Downgraded once. g. Indirectness: Single trial assessing 61 Iranian men, women and other countries not represented. Downgraded once. h. Imprecision: 95% CI includes both important benefits and some harm. Downgraded once. i. Risk of bias: the single trial was not at low summary risk of bias. Downgraded once. j. Indirectness: single trial in 24 Italians with Parkinson's Disease. Downgraded twice. k. Imprecision: Although there were only 8 events, the 95% CI included only benefits. Not downgraded. l. Risk of bias: effect did not differ in trials at low summary risk of bias, or in other sensitivity analyses. Not downgraded. m. Imprecision: 95% CI included only little or no effect. Not downgraded. n. Publication bias: Funnel plot suggests that some small studies with higher SMDs may be missing. Adding these back would tend to suggest slightly worse outcomes with LCn3. Downgraded once. o. Risk of bias: the single study was at large and at low summary risk of bias. Not downgraded. p. Indirectness: the single trial was conducted in UK diabetics. Downgraded once. q. Imprecision: the 95% CI included both important harms and important benefits. Downgraded twice. r. Risk of bias: no included trials were at low summary risk of bias. Downgraded once. s. Indirectness: included men and women with a variety of health conditions, though mainly from Europe. Not downgraded. t. Imprecision: 95% CI included only little or no effect. Not downgraded. Supplementary Table 4. High vs low ALA (primary outcomes)OutcomeSA or SubgroupStudiesParticipantsEffect Estimate (Risk Ratio, M-H, Random, 95% CI)*Risk of depression symptomsMain 140681.11 [0.67, 1.84]Summary risk of bias (SA)140681.11 [0.67, 1.84]Fixed effects (SA)140681.11 [0.67, 1.84](Risk Ratio, M-H, Fixed, 95% CI)Compliance (SA)140681.11 [0.67, 1.84]Larger trials (≥100 randomised, SA)140681.11 [0.67, 1.84]Depression symptoms (in those without depression at baseline)Main, GDS 14068-0.02 [-0.14, 0.10] MD (IV, Random, 95% CI)Summary risk of bias (SA)14068-0.02 [-0.14, 0.10] MD (IV, Random, 95% CI)Fixed effects (SA)14068-0.02 [-0.12, 0.09] MD (IV, Fixed, 95% CI)Compliance (SA)14068-0.02 [-0.14, 0.10] MD (IV, Random, 95% CI)Larger trials (≥100 randomised, SA)14068-0.02 [-0.14, 0.10] MD (IV, Random, 95% CI)Depression remissionMain 00Not estimableRisk of anxiety symptomsSymptomatic00Not estimableAnxiety symptoms00Not estimableAnxiety remission50% reduction00Not estimableSupplementary Table 5. High vs low total PUFA (primary outcomes) OutcomeSA or SubgroupStudiesParticipantsEffect Estimate (Risk Ratio, M-H, Random, 95% CI)*Risk of depression symptomsMain 127390.75 [0.54, 1.03]Summary risk of bias (SA)00Not estimableFixed effects (SA)127390.75 [0.54, 1.03](Risk Ratio, M-H, Fixed, 95% CI)Compliance (SA)00Not estimableLarger trials (≥100 randomised, SA)127390.75 [0.54, 1.03]Depression symptoms (in those without depression at baseline)Main 00Not estimableDepression remissionMain 00Not estimableRisk of anxiety symptomsSymptomatic00Not estimableAnxiety symptomsMain 00Not estimableAnxiety remission50% reduction00Not estimableSupplementary Table 6: GRADE assessment: Summary of findings for effects of total PUFA on depression and anxietyPatient or population: People at any baseline risk of depression and anxiety Setting: Trials of at least 6 months duration in any country or context Intervention: Higher total PUFA intakeComparison: lower total PUFA intakeOutcomesAnticipated absolute effects* (95% CI) Relative effect(95% CI) № of participants (studies) Certainty of the evidence(GRADE) CommentsRisk with lower total PUFARisk with higher total PUFARisk of depression symptoms61 per 1,000 46 per 1,000(33 to 63) RR 0.75(0.54 to 1.03) 2739(1 RCT) ????VERY LOW a b cWe are uncertain of the effect of increasing total PUFA as the evidence is of very low-quality. Downgraded once each for risk of bias, inconsistency and indirectness.Depression severity - (0 RCTs) -No RCTs assessed this outcome.Depression remission (50% reduction) (0 RCTs) - No RCTs assessed this outcome. Depression symptoms (in those without depression at baseline)(0 RCTs)-No RCTs assessed this outcome.Risk of anxiety symptoms(0 RCTs) - No RCTs assessed this outcome. Anxiety severity - - (0 RCTs) - No RCTs assessed this outcome. Anxiety remission (50% reduction) (0 RCTs) - No RCTs assessed this outcome. Anxiety symptoms(0 RCTs)-No RCTs assessed this outcome.*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; MD: Mean difference; SMD: Standardised mean difference GRADE Working Group grades of evidenceHigh certainty: We are very confident that the true effect lies close to that of the estimate of the effectModerate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially differentLow certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effectVery low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect ExplanationsRisk of bias: the included study was not at low summary risk of bias (or at low risk for compliance). Downgraded once. Inconsistency: only one trial, downgraded once. Indirectness: the single trial that provided data for this assessment compared increased nut intake (high in PUFA) with increased olive oil intake (high in MUFA). However, nuts are also rich sources of many vitamins and minerals including magnesium, selenium, zinc and B vitamins, so it is unclear whether the decrease in depression risk is due to PUFA or other dietary components. Supplementary Table 7: GRADE assessment: Summary of findings for effects of ALA on depression and anxietyPatient or population: People at any baseline risk of depression and anxiety Setting: Trials of at least 6 months duration of ALA in any country or context Intervention: Higher ALA intakeComparison: lower ALA intakeOutcomesAnticipated absolute effects* (95% CI) Relative effect(95% CI) № of participants (studies) Certainty of the evidence(GRADE) CommentsRisk with lower ALARisk with Higher ALARisk of depression symptoms14 per 1,000 15 per 1,000(9 to 25) RR 1.11(0.67 to 1.84) 4068(1 RCT) ????LOW aIncreasing ALA may increase the risk of diagnosis of depression very slightly, NNH 1000. Downgraded twice for imprecision.Depression severity in those with depression at baselinenot pooled-(0 RCTs)-No RCTs assessed this outcome.Depression remission (50% reduction) not pooled not pooled not pooled (0 RCTs) - No RCTs assessed this outcome. Depression symptoms (in those without depression at baseline) - assessed with GDS (Geriatric Depression Scale)The mean GDS at baseline was 1.49 The mean GDS in the intervention group was -0.02 lower (0.14 lower to 0.10 higher)- 4068(1 RCT) ????LOW b,cIncreasing ALA may have little or no effect on depression symptoms. Downgraded for imprecision and risk of bias. Risk of anxiety symptomsnot pooled not pooled not pooled (0 RCTs) - No RCTs assessed this outcome. Anxiety severity in those with anxiety at baselinenot pooled - - (0 RCTs) - No RCTs assessed this outcome. Anxiety remission (50% reduction) not pooled not pooled not pooled (0 RCTs) - No RCTs assessed this outcome. Anxiety symptoms in those without anxiety at baselinenot pooled-(0 RCTs)-No RCTs assessed this outcome.*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; MD: Mean difference; SMD: Standardised mean difference GRADE Working Group grades of evidenceHigh certainty: We are very confident that the true effect lies close to that of the estimate of the effectModerate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially differentLow certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effectVery low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect Explanationsa. Imprecision: 95% CI include both important harms and important benefits. Downgraded twice. b. Risk of bias: the included study was not at low summary risk of bias (or at low risk for compliance). Downgraded once. c. Imprecision: 95% CI included benefit of over 10% improvement in GDS score. Downgraded once. Supplementary Table 8. High vs low long-chain omega 3 (secondary outcomes)OutcomeSubgroupStudiesParticipantsStatistical MethodEffect EstimateSocial participation00Mean Difference (IV, Random, 95% CI)Not estimableQuality of life measures?Life satisfaction index (LSI) 1352Mean Difference (IV, Random, 95% CI)1.10 [0.14, 2.06]SF36 - mental 191Mean Difference (IV, Random, 95% CI)-0.60 [-3.10, 1.90]SF36 - physical 191Mean Difference (IV, Random, 95% CI)1.10 [-2.12, 4.32]Carer stressCaregiver burden (Zarit Burden Interview) 148Mean Difference (IV, Random, 95% CI)-3.49 [-7.02, 0.04]Emotional overload1174Mean Difference (IV, Random, 95% CI)0.00 [-0.91, 0.91]Economic overload1174Mean Difference (IV, Random, 95% CI)-0.20 [-0.56, 0.16]Healthcare and patient costs00Mean Difference (IV, Random, 95% CI)Not estimablePsychosis, suicidality, suicide or self-harmSuicide316433Risk Ratio (M-H, Random, 95% CI)0.99 [0.13, 7.73]Fidelity00Mean Difference (IV, Random, 95% CI)Not estimableAdverse eventsAny GI side effect 1211609Risk Ratio (M-H, Random, 95% CI)0.95 [0.80, 1.12]?Nausea 3651Risk Ratio (M-H, Random, 95% CI)1.14 [0.64, 2.05]Abdominal pain or discomfort 3271Risk Ratio (M-H, Random, 95% CI)1.03 [0.11, 9.21]Diarrhoea 3849Risk Ratio (M-H, Random, 95% CI)0.65 [0.43, 1.00]?Malignancy 12081Risk Ratio (M-H, Random, 95% CI)0.22 [0.15, 0.32]Urogenital system 43063Risk Ratio (M-H, Random, 95% CI)1.11 [0.83, 1.48]Respiratory system 53577Risk Ratio (M-H, Random, 95% CI)1.01 [0.61, 1.66]Musculoskeletal disorders32997Risk Ratio (M-H, Random, 95% CI)0.73 [0.45, 1.18]Falls or injuries 32687Risk Ratio (M-H, Random, 95% CI)1.52 [0.88, 2.62]Cardiovascular system 32971Risk Ratio (M-H, Random, 95% CI)1.19 [0.83, 1.68]Bleeding 43290Risk Ratio (M-H, Random, 95% CI)1.35 [0.82, 2.20]Skin problems (itching, rashes) 46831Risk Ratio (M-H, Random, 95% CI)0.80 [0.49, 1.32]Infections 22905Risk Ratio (M-H, Random, 95% CI)0.90 [0.77, 1.06]Brain and Nervous System 63834Risk Ratio (M-H, Random, 95% CI)0.97 [0.80, 1.17]Headache or worsening migraine 3651Risk Ratio (M-H, Random, 95% CI)0.77 [0.33, 1.82]Insomnia or fatigue 3712Risk Ratio (M-H, Random, 95% CI)1.11 [0.71, 1.73]Sense organs 22905Risk Ratio (M-H, Random, 95% CI)0.96 [0.70, 1.31]Hormonal 22385Risk Ratio (M-H, Random, 95% CI)1.11 [0.73, 1.70]Drop outs115654Risk Ratio (M-H, Random, 95% CI)0.94 [0.82, 1.09]Dropouts due to adverse events64976Risk Ratio (M-H, Random, 95% CI)0.99 [0.69, 1.42]Supplementary Table 9. High vs low ALA (secondary outcomes) OutcomeStudiesParticipants Statistical MethodEffect EstimateAny gastrointestinal side effect12433Risk Ratio (M-H, Random, 95% CI)0.93 [0.38, 2.28]Dropouts due to adverse events12433Risk Ratio (M-H, Random, 95% CI)0.89 [0.47, 1.65]Supplementary Table 10. Characteristics of ongoing trials that appear to have assessed relevant outcomes for this reviewBeyond Aging Project PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db2NrYXluZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

PFJlY051bT4zMDc5PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig1MSk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MzA3OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjExMTE4Ij4zMDc5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Db2NrYXluZSwgTi4gTC48L2F1dGhvcj48YXV0aG9yPkR1ZmZ5LCBTLiBMLjwvYXV0aG9yPjxh

dXRob3I+Qm9ub21hbGx5LCBSLjwvYXV0aG9yPjxhdXRob3I+RW5nbGlzaCwgQS48L2F1dGhvcj48

YXV0aG9yPkFtbWluZ2VyLCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+TWFja2lubm9uLCBBLjwvYXV0

aG9yPjxhdXRob3I+Q2hyaXN0ZW5zZW4sIEguIE0uPC9hdXRob3I+PGF1dGhvcj5OYWlzbWl0aCwg

Uy4gTC48L2F1dGhvcj48YXV0aG9yPkhpY2tpZSwgSS4gQi48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Db2NrYXluZSxOaWNvbGUgTC4gSGVhbHRoeSBCcmFp

biBBZ2VpbmcgUHJvZ3JhbSwgQnJhaW4gYW5kIE1pbmQgUmVzZWFyY2ggSW5zdGl0dXRlLCBVbml2

ZXJzaXR5IG9mIFN5ZG5leSwgOTQgTWFsbGV0dCBTdHJlZXQsIENhbXBlcmRvd24sIE5TVywgMjA1

MCwgQXVzdHJhbGlhLiBuaWNvbGUuY29ja2F5bmVAc3lkbmV5LmVkdS5hdS4gRHVmZnksU2hhbnRl

bCBMLiBIZWFsdGh5IEJyYWluIEFnZWluZyBQcm9ncmFtLCBCcmFpbiBhbmQgTWluZCBSZXNlYXJj

aCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgU3lkbmV5LCA5NCBNYWxsZXR0IFN0cmVldCwgQ2Ft

cGVyZG93biwgTlNXLCAyMDUwLCBBdXN0cmFsaWEuIHNoYW50ZWwuZHVmZnlAc3lkbmV5LmVkdS5h

dS4gQm9ub21hbGx5LFJvc2FsaW5kLiBIZWFsdGh5IEJyYWluIEFnZWluZyBQcm9ncmFtLCBCcmFp

biBhbmQgTWluZCBSZXNlYXJjaCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgU3lkbmV5LCA5NCBN

YWxsZXR0IFN0cmVldCwgQ2FtcGVyZG93biwgTlNXLCAyMDUwLCBBdXN0cmFsaWEuIHJvc2FsaW5k

LmJvbm9tYWxseUBzeWRuZXkuZWR1LmF1LiBFbmdsaXNoLEFtZWxpYS4gSGVhbHRoeSBCcmFpbiBB

Z2VpbmcgUHJvZ3JhbSwgQnJhaW4gYW5kIE1pbmQgUmVzZWFyY2ggSW5zdGl0dXRlLCBVbml2ZXJz

aXR5IG9mIFN5ZG5leSwgOTQgTWFsbGV0dCBTdHJlZXQsIENhbXBlcmRvd24sIE5TVywgMjA1MCwg

QXVzdHJhbGlhLiBhbWVsaWEuZW5nbGlzaEBzeWRuZXkuZWR1LmF1LiBBbW1pbmdlcixQYXVsIEcu

IE9yeWdlbiAtIFRoZSBOYXRpb25hbCBDZW50cmUgb2YgRXhjZWxsZW5jZSBpbiBZb3V0aCBNZW50

YWwgSGVhbHRoLCBUaGUgVW5pdmVyc2l0eSBvZiBNZWxib3VybmUsIExvY2tlZCBCYWcgMTAsIFBh

cmt2aWxsZSwgVklDLCAzMDUyLCBBdXN0cmFsaWEuIHBhdWwuYW1taW5nZXJAb3J5Z2VuLm9yZy5h

dS4gTWFja2lubm9uLEFuZHJldy4gT3J5Z2VuIC0gVGhlIE5hdGlvbmFsIENlbnRyZSBvZiBFeGNl

bGxlbmNlIGluIFlvdXRoIE1lbnRhbCBIZWFsdGgsIFRoZSBVbml2ZXJzaXR5IG9mIE1lbGJvdXJu

ZSwgTG9ja2VkIEJhZyAxMCwgUGFya3ZpbGxlLCBWSUMsIDMwNTIsIEF1c3RyYWxpYS4gQW5kcmV3

Lk1hY2tpbm5vbkB1bmltZWxiLmVkdS5hdS4gQ2hyaXN0ZW5zZW4sSGVsZW4gTS4gQmxhY2sgRG9n

IEluc3RpdHV0ZSwgVW5pdmVyc2l0eSBvZiBOZXcgU291dGggV2FsZXMsIEhvc3BpdGFsIFJvYWQs

IFByaW5jZSBvZiBXYWxlcyBIb3NwaXRhbCwgUmFuZHdpY2ssIE5TVywgMjAzMSwgQXVzdHJhbGlh

LiBoLmNocmlzdGVuc2VuQGJsYWNrZG9nLm9yZy5hdS4gTmFpc21pdGgsU2hhcm9uIEwuIEhlYWx0

aHkgQnJhaW4gQWdlaW5nIFByb2dyYW0sIEJyYWluIGFuZCBNaW5kIFJlc2VhcmNoIEluc3RpdHV0

ZSwgVW5pdmVyc2l0eSBvZiBTeWRuZXksIDk0IE1hbGxldHQgU3RyZWV0LCBDYW1wZXJkb3duLCBO

U1csIDIwNTAsIEF1c3RyYWxpYS4gc2hhcm9uLm5haXNtaXRoQHN5ZG5leS5lZHUuYXUuIEhpY2tp

ZSxJYW4gQi4gSGVhbHRoeSBCcmFpbiBBZ2VpbmcgUHJvZ3JhbSwgQnJhaW4gYW5kIE1pbmQgUmVz

ZWFyY2ggSW5zdGl0dXRlLCBVbml2ZXJzaXR5IG9mIFN5ZG5leSwgOTQgTWFsbGV0dCBTdHJlZXQs

IENhbXBlcmRvd24sIE5TVywgMjA1MCwgQXVzdHJhbGlhLiBpYW4uaGlja2llQHN5ZG5leS5lZHUu

YXU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgQmV5b25kIEFnZWluZyBQcm9qZWN0

IFBoYXNlIDItLWEgZG91YmxlLWJsaW5kLCBzZWxlY3RpdmUgcHJldmVudGlvbiwgcmFuZG9taXNl

ZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIG9mIG9tZWdhLTMgZmF0dHkgYWNpZHMgYW5kIHNl

cnRyYWxpbmUgaW4gYW4gb2xkZXIgYWdlIGNvaG9ydCBhdCByaXNrIGZvciBkZXByZXNzaW9uOiBz

dHVkeSBwcm90b2NvbCBmb3IgYSByYW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+VHJpYWxzIFtFbGVjdHJvbmljIFJlc291cmNlXTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+VHJpYWxzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+VHJpYWxzIFtFbGVjdHJvbmljIFJlc291cmNlXTwvZnVsbC10aXRsZT48YWJici0x

PlRyaWFsczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

VHJpYWxzPC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI0NzwvcGFnZXM+PHZv

bHVtZT4xNjwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlIEZhY3RvcnMgQWdlZCBBZ2luZy9weCBbUHN5Y2hv

bG9neV0gQW50aWRlcHJlc3NpdmUgQWdlbnRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdICpBbnRpZGVw

cmVzc2l2ZSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gQ2xpbmljYWwgUHJvdG9jb2xzIERl

cHJlc3Npb24vZGkgW0RpYWdub3Npc10gRGVwcmVzc2lvbi9wcCBbUGh5c2lvcGF0aG9sb2d5XSAq

RGVwcmVzc2lvbi9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSBEZXByZXNzaW9uL3A8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVzPjxpc2JuPjE3

NDUtNjIxNTwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjExODYvczEzMDYz

LTAxNS0wNzYyLTY7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQs

IE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX

Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI2MDM3NDg0aHR0cDovL3Nm

eC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYwMzc0

ODQmYW1wO2lkPWRvaToxMC4xMTg2JTJGczEzMDYzLTAxNS0wNzYyLTYmYW1wO2lzc249MTc0NS02

MjE1JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTE2JmFtcDtpc3N1ZT0mYW1wO3NwYWdlPTI0NyZhbXA7

cGFnZXM9MjQ3JmFtcDtkYXRlPTIwMTUmYW1wO3RpdGxlPVRyaWFscyslNUJFbGVjdHJvbmljK1Jl

c291cmNlJTVEJmFtcDthdGl0bGU9VGhlK0JleW9uZCtBZ2VpbmcrUHJvamVjdCtQaGFzZSsyLS1h

K2RvdWJsZS1ibGluZCUyQytzZWxlY3RpdmUrcHJldmVudGlvbiUyQytyYW5kb21pc2VkJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtvZitvbWVnYS0zK2ZhdHR5K2FjaWRzK2FuZCtzZXJ0cmFs

aW5lK2luK2FuK29sZGVyK2FnZStjb2hvcnQrYXQrcmlzaytmb3IrZGVwcmVzc2lvbiUzQStzdHVk

eStwcm90b2NvbCtmb3IrYStyYW5kb21pemVkK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9

Q29ja2F5bmU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Db2NrYXluZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+

PFJlY051bT4zMDc5PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig1MSk8L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MzA3OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9IjUyejkwYXc1anJ2c3M1ZTVlMGV2ZnNzNGFhdHR0ZmQ1ZnMwdCIgdGltZXN0YW1w

PSIxNTMwMjExMTE4Ij4zMDc5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Db2NrYXluZSwgTi4gTC48L2F1dGhvcj48YXV0aG9yPkR1ZmZ5LCBTLiBMLjwvYXV0aG9yPjxh

dXRob3I+Qm9ub21hbGx5LCBSLjwvYXV0aG9yPjxhdXRob3I+RW5nbGlzaCwgQS48L2F1dGhvcj48

YXV0aG9yPkFtbWluZ2VyLCBQLiBHLjwvYXV0aG9yPjxhdXRob3I+TWFja2lubm9uLCBBLjwvYXV0

aG9yPjxhdXRob3I+Q2hyaXN0ZW5zZW4sIEguIE0uPC9hdXRob3I+PGF1dGhvcj5OYWlzbWl0aCwg

Uy4gTC48L2F1dGhvcj48YXV0aG9yPkhpY2tpZSwgSS4gQi48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Db2NrYXluZSxOaWNvbGUgTC4gSGVhbHRoeSBCcmFp

biBBZ2VpbmcgUHJvZ3JhbSwgQnJhaW4gYW5kIE1pbmQgUmVzZWFyY2ggSW5zdGl0dXRlLCBVbml2

ZXJzaXR5IG9mIFN5ZG5leSwgOTQgTWFsbGV0dCBTdHJlZXQsIENhbXBlcmRvd24sIE5TVywgMjA1

MCwgQXVzdHJhbGlhLiBuaWNvbGUuY29ja2F5bmVAc3lkbmV5LmVkdS5hdS4gRHVmZnksU2hhbnRl

bCBMLiBIZWFsdGh5IEJyYWluIEFnZWluZyBQcm9ncmFtLCBCcmFpbiBhbmQgTWluZCBSZXNlYXJj

aCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgU3lkbmV5LCA5NCBNYWxsZXR0IFN0cmVldCwgQ2Ft

cGVyZG93biwgTlNXLCAyMDUwLCBBdXN0cmFsaWEuIHNoYW50ZWwuZHVmZnlAc3lkbmV5LmVkdS5h

dS4gQm9ub21hbGx5LFJvc2FsaW5kLiBIZWFsdGh5IEJyYWluIEFnZWluZyBQcm9ncmFtLCBCcmFp

biBhbmQgTWluZCBSZXNlYXJjaCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgU3lkbmV5LCA5NCBN

YWxsZXR0IFN0cmVldCwgQ2FtcGVyZG93biwgTlNXLCAyMDUwLCBBdXN0cmFsaWEuIHJvc2FsaW5k

LmJvbm9tYWxseUBzeWRuZXkuZWR1LmF1LiBFbmdsaXNoLEFtZWxpYS4gSGVhbHRoeSBCcmFpbiBB

Z2VpbmcgUHJvZ3JhbSwgQnJhaW4gYW5kIE1pbmQgUmVzZWFyY2ggSW5zdGl0dXRlLCBVbml2ZXJz

aXR5IG9mIFN5ZG5leSwgOTQgTWFsbGV0dCBTdHJlZXQsIENhbXBlcmRvd24sIE5TVywgMjA1MCwg

QXVzdHJhbGlhLiBhbWVsaWEuZW5nbGlzaEBzeWRuZXkuZWR1LmF1LiBBbW1pbmdlcixQYXVsIEcu

IE9yeWdlbiAtIFRoZSBOYXRpb25hbCBDZW50cmUgb2YgRXhjZWxsZW5jZSBpbiBZb3V0aCBNZW50

YWwgSGVhbHRoLCBUaGUgVW5pdmVyc2l0eSBvZiBNZWxib3VybmUsIExvY2tlZCBCYWcgMTAsIFBh

cmt2aWxsZSwgVklDLCAzMDUyLCBBdXN0cmFsaWEuIHBhdWwuYW1taW5nZXJAb3J5Z2VuLm9yZy5h

dS4gTWFja2lubm9uLEFuZHJldy4gT3J5Z2VuIC0gVGhlIE5hdGlvbmFsIENlbnRyZSBvZiBFeGNl

bGxlbmNlIGluIFlvdXRoIE1lbnRhbCBIZWFsdGgsIFRoZSBVbml2ZXJzaXR5IG9mIE1lbGJvdXJu

ZSwgTG9ja2VkIEJhZyAxMCwgUGFya3ZpbGxlLCBWSUMsIDMwNTIsIEF1c3RyYWxpYS4gQW5kcmV3

Lk1hY2tpbm5vbkB1bmltZWxiLmVkdS5hdS4gQ2hyaXN0ZW5zZW4sSGVsZW4gTS4gQmxhY2sgRG9n

IEluc3RpdHV0ZSwgVW5pdmVyc2l0eSBvZiBOZXcgU291dGggV2FsZXMsIEhvc3BpdGFsIFJvYWQs

IFByaW5jZSBvZiBXYWxlcyBIb3NwaXRhbCwgUmFuZHdpY2ssIE5TVywgMjAzMSwgQXVzdHJhbGlh

LiBoLmNocmlzdGVuc2VuQGJsYWNrZG9nLm9yZy5hdS4gTmFpc21pdGgsU2hhcm9uIEwuIEhlYWx0

aHkgQnJhaW4gQWdlaW5nIFByb2dyYW0sIEJyYWluIGFuZCBNaW5kIFJlc2VhcmNoIEluc3RpdHV0

ZSwgVW5pdmVyc2l0eSBvZiBTeWRuZXksIDk0IE1hbGxldHQgU3RyZWV0LCBDYW1wZXJkb3duLCBO

U1csIDIwNTAsIEF1c3RyYWxpYS4gc2hhcm9uLm5haXNtaXRoQHN5ZG5leS5lZHUuYXUuIEhpY2tp

ZSxJYW4gQi4gSGVhbHRoeSBCcmFpbiBBZ2VpbmcgUHJvZ3JhbSwgQnJhaW4gYW5kIE1pbmQgUmVz

ZWFyY2ggSW5zdGl0dXRlLCBVbml2ZXJzaXR5IG9mIFN5ZG5leSwgOTQgTWFsbGV0dCBTdHJlZXQs

IENhbXBlcmRvd24sIE5TVywgMjA1MCwgQXVzdHJhbGlhLiBpYW4uaGlja2llQHN5ZG5leS5lZHUu

YXU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgQmV5b25kIEFnZWluZyBQcm9qZWN0

IFBoYXNlIDItLWEgZG91YmxlLWJsaW5kLCBzZWxlY3RpdmUgcHJldmVudGlvbiwgcmFuZG9taXNl

ZCwgcGxhY2Viby1jb250cm9sbGVkIHRyaWFsIG9mIG9tZWdhLTMgZmF0dHkgYWNpZHMgYW5kIHNl

cnRyYWxpbmUgaW4gYW4gb2xkZXIgYWdlIGNvaG9ydCBhdCByaXNrIGZvciBkZXByZXNzaW9uOiBz

dHVkeSBwcm90b2NvbCBmb3IgYSByYW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxz

ZWNvbmRhcnktdGl0bGU+VHJpYWxzIFtFbGVjdHJvbmljIFJlc291cmNlXTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+VHJpYWxzPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+VHJpYWxzIFtFbGVjdHJvbmljIFJlc291cmNlXTwvZnVsbC10aXRsZT48YWJici0x

PlRyaWFsczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

VHJpYWxzPC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjI0NzwvcGFnZXM+PHZv

bHVtZT4xNjwvdm9sdW1lPjxyZXByaW50LWVkaXRpb24+Tk9UIElOIEZJTEU8L3JlcHJpbnQtZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlIEZhY3RvcnMgQWdlZCBBZ2luZy9weCBbUHN5Y2hv

bG9neV0gQW50aWRlcHJlc3NpdmUgQWdlbnRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdICpBbnRpZGVw

cmVzc2l2ZSBBZ2VudHMvdHUgW1RoZXJhcGV1dGljIFVzZV0gQ2xpbmljYWwgUHJvdG9jb2xzIERl

cHJlc3Npb24vZGkgW0RpYWdub3Npc10gRGVwcmVzc2lvbi9wcCBbUGh5c2lvcGF0aG9sb2d5XSAq

RGVwcmVzc2lvbi9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXSBEZXByZXNzaW9uL3A8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVzPjxpc2JuPjE3

NDUtNjIxNTwvaXNibj48d29yay10eXBlPmh0dHA6Ly9keC5kb2kub3JnLzEwLjExODYvczEzMDYz

LTAxNS0wNzYyLTY7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsIFJlc2VhcmNoIFN1cHBvcnQs

IE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX

Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI2MDM3NDg0aHR0cDovL3Nm

eC51Y2wuYWMudWsvc2Z4X2xvY2FsP3NpZD1PVklEOm1lZGxpbmUmYW1wO2lkPXBtaWQ6MjYwMzc0

ODQmYW1wO2lkPWRvaToxMC4xMTg2JTJGczEzMDYzLTAxNS0wNzYyLTYmYW1wO2lzc249MTc0NS02

MjE1JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTE2JmFtcDtpc3N1ZT0mYW1wO3NwYWdlPTI0NyZhbXA7

cGFnZXM9MjQ3JmFtcDtkYXRlPTIwMTUmYW1wO3RpdGxlPVRyaWFscyslNUJFbGVjdHJvbmljK1Jl

c291cmNlJTVEJmFtcDthdGl0bGU9VGhlK0JleW9uZCtBZ2VpbmcrUHJvamVjdCtQaGFzZSsyLS1h

K2RvdWJsZS1ibGluZCUyQytzZWxlY3RpdmUrcHJldmVudGlvbiUyQytyYW5kb21pc2VkJTJDK3Bs

YWNlYm8tY29udHJvbGxlZCt0cmlhbCtvZitvbWVnYS0zK2ZhdHR5K2FjaWRzK2FuZCtzZXJ0cmFs

aW5lK2luK2FuK29sZGVyK2FnZStjb2hvcnQrYXQrcmlzaytmb3IrZGVwcmVzc2lvbiUzQStzdHVk

eStwcm90b2NvbCtmb3IrYStyYW5kb21pemVkK2NvbnRyb2xsZWQrdHJpYWwuJmFtcDthdWxhc3Q9

Q29ja2F5bmU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT5=

ADDIN EN.CITE.DATA (51)Study nameThe Beyond Ageing Project Phase 2: A selective prevention trial using novel pharmacotherapies in an older age cohort at risk for depressionMethodsRCTParticipantsOlder adults (60+ years) at risk of depression (K-10 score ranging from 16-29) who initially participated in the first Beyond Ageing ProjectInterventionsEach for 12 months:Arm 1: omega-3 (4 capsules, total 2g/d: 1200mg EPA and 800mg DHA) and placebo microcrystalline cellulose (1 capsule)Arm 2: paraffin oil placebo (4 capsules) and sertraline hydrochloride (1 capsule, 50mg)Arm 3: paraffin oil placebo (4 capsules) and placebo microcrystalline cellulose (1 capsule)OutcomesPrimary: depressive symptoms (PHQ-9)Secondary: cognitive decline, MMSE, brain metabolism, hippocampal volume, anxiety (GAD-7), disability (WHODAS-II), sleeping problems (PSQI), exercise (Active Australian Survey)Starting dateRegistered on Trials Registry: 12 Jan 2010Study start date: June 2011Study completion date est: Main results expected in 2017Contact informationIan Hickie (PI), Brain and Mind Centre, University of Sydney, ian.hickie@sydney.adu.auNotesACTRN12610000032055Cai 2017 ADDIN EN.CITE <EndNote><Cite><Author>Cai</Author><Year>2017</Year><RecNum>20012</RecNum><DisplayText>(52)</DisplayText><record><rec-number>20012</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1530355421">20012</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cai, S.</author><author>Coates, A. M.</author><author>Buckley, J. D.</author><author>Berry, N. M.</author><author>Burres, L.</author><author>Beltrame, J.</author><author>Howe, P. R. C.</author><author>Schrader, G.</author></authors></contributors><titles><title>There is No Association Between the Omega-3 Index and Depressive Symptomsin Patients With Heart Disease Who Are Low Fish Consumers</title><secondary-title>Heart, Lung and Circulation</secondary-title></titles><periodical><full-title>Heart, Lung &amp; Circulation</full-title><abbr-1>Heart Lung Circ</abbr-1><abbr-2>Heart, Lung and Circulation</abbr-2></periodical><pages>276-284</pages><volume>26</volume><dates><year>2017</year></dates><urls></urls></record></Cite></EndNote>(52)Study nameOmega-3 fatty acid supplementation for symptoms of depression in patients with cardiovascular diseaseMethodsRCT, parallel groups. Both the participants and the researchers were blinded to whether they were in the fish oil or placebo groups.Participants91 patients (65 males and 26 females, mean age 59.2 (10.3) years) with heart disease and depressive symptoms (Center for Epidemiological Studies Depression Scale, CES-D) and low fish/fish oil intakes.InterventionsIntervention: Four 1 gram capsules of eicosapentaenoic acid (EPA)-rich fish oil per day for 6 months. Each capsule will contain 500mg of eicosapentaenoic acid (EPA) and 25 mg of docosahexaenoic acid (DHA).Placebo: Four 1 gram capsules of soybean/corn oil per day for 6 months. Each capsule will contain 500mg of soybean oil and 500 mg of corn oil.OutcomesPrimary: Depression (Hamilton Rating Scale For Depression)Secondary: Quality of Life (Short Form (SF)-36)Angina frequency (Seattle Angina Questionnaire)Degree of change in vasodilator function assessed by flow mediated dilatation (FMD) in the brachial arteryChanges in cerebral blood flow measured by transcranial Doppler ultrasoundStarting dateParticipants were recruited in 2009-2013. Trial was registered 1/12/2008Contact informationAlison Coates, School of Health Sciences, Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for Health Research, University of South Australia, PO Box 2471, Adelaide, South Australia. Alison.coates@unisa.edu.auNotesACTRN12608000598381The authors confirm that the main outcomes are still being analysed.Chiang Chiu 2010 ?Study nameThe Assessment for the Effects of Health Products on Depression and Cognitive Function: Fish Oil in Patients With Late-life DepressionMethodsRCT, parallel groups, double-blindParticipantsOlder people with major depressionInterventionsIntervention: three capsules of n-3 fatty acids. Each capsule included 600mg eicosapentanoic acid (20:5n-3), 400 mg of docosahexanoic acid (22:6n-3), tertiary-butylhydroquinone 0.2 mg/g and tocopherols 2 mg/g.Placebo: three identical capsules per day. All capsules included olive oil.OutcomesRecurrence of depressionChange of cognitive functionStarting dateStudy start date: May 2007Study Completion Date: September 2010Contact informationChih-Chiang Chiu, Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, No. 309, Sungde Road, Taipei 110, Taiwan.Email: chiu@NotesNCT01235533DO Health ?Study nameVitamin D3- Omega3- Home Exercise- Healthy Ageing and Lengevity Trial (DO-HEALTH)MethodsRCTParticipantsCommunity dwelling adults 70 years and older, 50% of seniors enrolled based on a fall in the year before enrollmentInterventionsEach for 3 years:Arm 1: omega 3 (1g/d, ratio EPA:DHA = 1:2) and vitamin D3 (2000 IU/d) capsules and strength home exercise (3x30 mins/week)Arm 2: omega 3 (1g/d, ratio EPA:DHA = 1:2) and vitamin D3 (2000 IU/d) capsules and flexibility home exercise (3x30 mins/week)Arm 3: omega 3 (1g/d, ratio EPA:DHA = 1:2) and placebo capsules and strength home exercise (3x30 mins/week)Arm 4: omega 3 (1g/d, ratio EPA:DHA = 1:2) and placebo capsules and flexibility home exercise (3x30 mins/week)Arm 5: placebo and vitamin D3 (2000 IU/d) capsules and strength home exercise (3x30 mins/week)Arm 6: placebo and vitamin D3 (2000 IU/d) capsules and flexibility home exercise (3x30 mins/week)Arm 7: placebo and placebo capsules and strength home exercise (3x30 mins/week)Arm 8: placebo and placebo capsules and flexibility home exercise (3x30 mins/week)OutcomesPrimary: non-vertebral fractures, functional decline, blood pressure, cognitive decline, rate of any infectionSecondary: other fractures, falls, pain in knee osteoarthritis, musculoskeletal changes, gastro-intestinal symptoms, mental and oral health, quality of life, life-expectancy, cardiovascular events, cancer, glucose measures, cost-benefit. All endpoints supported by a DO-HEALTH biomarker studyStarting dateRegistered on Trials Registry: 6 Dec 2012Study start date: Dec 2012Study completion date est: Nov 2017Contact informationHeike Bischoff-Ferrari (PI), Centre on Aging and Mobility, University of ZurichNotesNCT01745263EudraCT: 2012-001249-41do-health.euInTrePad ?Study nameIntervention of Testosterone & Fish Oil for the Prevention of Alzheimer's Disease: InTrePadMethodsRCTParticipantsPiB-PET (Pittsburgh compound B) positive men aged 60 years and over with Subjective Memory ComplaintsInterventionsEach for 56 weeks:Arm 1: DHA capsules (1720mg/d) and testosterone undecanoate (intramuscular injection 1000mg/4ml every 8 weeks)Arm 2: placebo DHA and testosterone undecanoate (intramuscular injection 1000mg/4ml every 8 weeks)Arm 3: placebo DHA and placebo testosteroneOutcomesPrimary: PiB scoreSecondary: neuropsychological, mood and daily functioning questionnaires, beta amyloid levels, fluorodeoxyglucose to assess brain glucose metabolism, inflammatory and oxidative biomarkers, hippocampal volume, quality of life, safety and tolerability of treatmentStarting dateRegistered on Trials Registry: 14 Jan 2013Study start date: 28 Feb 2013Study completion date est: unclearContact informationRalph Martins (PI), Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Medical Centre, Nedlands, Australia, r.martins@ecu.edu.auNotesACTRN12613000034730Ralph Martins written to in 2016- no responseIrish Omega-3 NCT02848469 ?Study nameIrish Omega-3 StudyMethodsRCT, 2 arms (LCn3 vs placebo), 6 monthsParticipantsParticipants at ultra high risk of psychosis (aged 13 to 45 years)InterventionsInt: 200ml juice drink including 1g EPA and 1g DHACont: 200ml juice drink without omega 3 (no fish taste in either)OutcomesPrimary: transition to psychosisSecondary: fatty acid changesStarting dateRegistered on Trials Registry: 25 July 2016Study start date: Sept 2013Estimated study completion date: February 2018Contact informationM Rooney (PI), University College CorkNotesNCT02848469n-3 for Vascular Cognitive Aging-NCT01953705 ? ADDIN EN.CITE <EndNote><Cite><Author>Bowman</Author><Year>2019</Year><RecNum>22147</RecNum><DisplayText>(53)</DisplayText><record><rec-number>22147</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1564739742">22147</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bowman, L. Gene</author><author>Silbert, C. Lisa</author><author>Dodge, H. Hiroko</author><author>Lahna, David</author><author>Hagen, Kirsten</author><author>Murchison, F. Charles</author><author>Howieson, Diane</author><author>Kaye, Jeffrey</author><author>Quinn, F. Joseph</author><author>Shinto, Lynne</author></authors></contributors><titles><title>Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results</title><secondary-title>Nutrients</secondary-title></titles><periodical><full-title>Nutrients</full-title></periodical><volume>11</volume><number>4</number><keywords><keyword>white matter hyperintensities</keyword><keyword>cognitive decline</keyword><keyword>vascular cognitive impairment</keyword><keyword>executive function</keyword><keyword>eicosapentaenoic acid</keyword><keyword>docosahexaenoic acid</keyword><keyword>neuroimaging</keyword><keyword>MRI</keyword><keyword>elderly</keyword></keywords><dates><year>2019</year></dates><isbn>2072-6643</isbn><urls></urls><electronic-resource-num>DOI: 10.3390/nu11040735</electronic-resource-num></record></Cite></EndNote>(53)Study namen-3 PUFA for Vascular Cognitive AgingMethodsRCTParticipantsOlder adults (80 years and older) at high risk for cognitive decline and dementia of Alzheimer's typeInterventionsEach for 3 years:Arm 1: omega 3 fish oil (1.65g/d EPA+DHA)Arm 2: soybean oil placebo (1.65g/d)OutcomesPrimary: total cerebral white matter volumeSecondary: biomarkers of endothelial health, total brain atrophy, medial temporal lobe atrophy, ventricular expansion, trail making test part B, digit symbol WAIS-R, cerebral blood flow, fractional anisotropy within frontal gyriStarting dateRegistered on Trials Registry: 24 Sept 2013Study start date: May 2014Study completion date est: March 2019Contact informationAlena Borgatti, borgatti@ohsu.edu; James Dursch, dursch@ohsu.edu; Gene Bowman and Lynne Shinto (PIs), Oregon Health and Science UniversityNotesNCT01953705NAYAB Qurashi 2017 ADDIN EN.CITE <EndNote><Cite><Author>Qurashi</Author><Year>2017</Year><RecNum>22158</RecNum><DisplayText>(54)</DisplayText><record><rec-number>22158</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1565004134">22158</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Qurashi, Inti</author><author>Chaudhry, Imran B.</author><author>Khoso, Ameer B.</author><author>Farooque, Sana</author><author>Lane, Steve</author><author>Husain, Mohammad Omair</author><author>Chu, Simon</author><author>Sarginson, Jane</author><author>Hamarani, Munir</author><author>Naqvi, Haider A.</author><author>Razzaque, Bushra</author><author>Minhas, Fareed A.</author><author>Yung, Alison R.</author><author>Deakin, J. F. W.</author><author>Husain, Nusrat</author></authors></contributors><titles><title>A randomised, double-blind, placebo-controlled trial of minocycline and/or omega-3 fatty acids added to treatment as usual for at-risk mental states (NAYAB): study protocol</title><secondary-title>Trials</secondary-title></titles><periodical><full-title>Trials</full-title></periodical><pages>524</pages><volume>18</volume><number>1</number><dates><year>2017</year><pub-dates><date>2017/11/09</date></pub-dates></dates><isbn>1745-6215</isbn><urls><related-urls><url>: 10.1186/s13063-017-2275-y</electronic-resource-num></record></Cite></EndNote>(54)?Study nameMinocycline and/or omega-3 fatty acids added to treatment as usual for at-risk mental states (NAYAB)MethodsRCT (2x2)ParticipantsPeople aged 16 to 35 years with at-risk mental state (ARM)InterventionsEach for 6 months:Intervention: 1.2 g/day concentrated marine fish oil (2 capsules/d together providing 720 mg/d EPA & 480 mg/d DHA)Control: matched soft gel capsules, content unclearBoth plus or minus minocycline tablet (2x2)OutcomesPrimary: transition to psychotic disorderSecondary: severity of depression symptoms (Montgomery-?sberg Depression Rating Scale, MADRS), ARMS symptoms, social and occupational function, cognitive scores, medication, adverse effectsStarting dateRegistered on Trials Registry: October 2015Study start date: October 2015Study completion date est: December 2018Contact informationInti Qurashi, Manchester University, Inti.Qurashi@merseycare.nhs.ukNotesNCT02569307Phosphatidylserine for Mild Cognitive Impairment?Study nameInvestigating a phosphatidylserine based dietary approach for the management of mild cognitive impairmentMethodsRCTParticipantsPeople with mild cognitive impairment (MCI) aged 65 to 85 yearsInterventionsEach for 24 months:Arm 1: phosphatidylserine omega 3 (DHA enriched)Arm 2: placebo cellulose capsulesOutcomesPrimary: selective reminding test (SRT)Secondary: mini mental state examination (MMSE), neurological battery test (NBT), dementia (DSM-4 criteria), mini sleep questionnaire (MSQ), Hamilton Anxiety rating scale (HAM-A), safety and adverse eventsStarting dateRegistered on Trials Registry: 6 Aug 2014Study start date: Sept 2014Study completion date est: Sept 2019Contact informationNadia Niemerzyanski, nadiaN@; Yael Richter, yaelr@NotesNCT02211560Terminated due to difficulties in participant recruitment – not known whether results exist for those participatingStoll 2001 ?Study nameOmega 3 fatty acids in bipolar disorder prophylaxisMethodsRCTParticipantsPeople aged 18 to 65 with bipolar disorderInterventionsEach for 12 months:Arm 1: omega 3Arm 2: placeboOutcomesProphylactic efficacyStarting dateTrial Registration entry: 2 Feb 2001Trial start date: July 2000Estimated study completion: July 2004Contact informationAndrew Stoll, Mclean HospitalNotesNCT00010868The PI, Andrew Stoll, appears to have been struck off the medical register in Massachusetts in 2011 (Commonwealth of Massachusetts Board of Registration in Medicine, Adjudicatory Case number 2011-026) so it has not been possible to contact him and no publication of results has been foundVITAL-DEP 2018 ADDIN EN.CITE <EndNote><Cite><Author>Okereke</Author><Year>2018</Year><RecNum>22159</RecNum><DisplayText>(55)</DisplayText><record><rec-number>22159</rec-number><foreign-keys><key app="EN" db-id="52z90aw5jrvss5e5e0evfss4aatttfd5fs0t" timestamp="1565006636">22159</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Okereke, Olivia I.</author><author>Reynolds, Charles F., III</author><author>Mischoulon, David</author><author>Chang, Grace</author><author>Cook, Nancy R.</author><author>Copeland, Trisha</author><author>Friedenberg, Georgina</author><author>Buring, Julie E.</author><author>Manson, JoAnn E.</author></authors></contributors><titles><title>The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression</title><secondary-title>Contemporary Clinical Trials</secondary-title></titles><periodical><full-title>Contemporary Clinical Trials</full-title><abbr-1>Contemp Clin Trials</abbr-1></periodical><pages>133-145</pages><volume>68</volume><dates><year>2018</year></dates><publisher>Elsevier</publisher><isbn>1551-7144</isbn><urls><related-urls><url>: 10.1016/t.2018.02.017</electronic-resource-num><access-date>2019/08/05</access-date></record></Cite></EndNote>(55) ?Study nameThe VITamin D and OmegA-3 TriaL - Depression Endpoint Prevention (VITAL-DEP)MethodsRCTParticipantsMulti-ethnic population of apparently healthy adults (men 50 years plus, women 55 years plus) without cancer, cardiovascular disease or depression at baselineInterventionsEach for mean 5 years:Arm 1: omega 3 (Omacor fish oil, EPA+DHA 1g/d: 465mg EPA; 375mg DHA) and placeboArm 2: placebo and vitamin D3 (1/d, 2000IU)Arm 3: omega 3 (Omacor fish oil, EPA+DHA 1g/d: 465mg EPA; 375mg DHA) and vitamin D3 (1/d, 2000IU)Arm 4: placebo and placeboOutcomesPatient Health Questionnaire 8 (PHQ8), other self-reported depression measures and health service use measures related to depression (plus additional measures in participants at high risk of depression)Starting dateTrial Registration entry: 1 Oct 2012Trial start date: July 2010Estimated study completion: May 2020Contact informationOlivia I. Okereke, MD, SM, Principal Investigator, Brigham and Women's Hospital, Brigham and Women's HospitalNotesNCT01696435Supplementary Figure 1. Study flow diagram. Supplementary Figure 2. Meta-analysis of effects of higher LCn3 vs lower LCn3 on risk of depression symptoms, sub-grouped by LCn3 dose. Supplementary Figure 3. Meta-analysis of effects of higher LCn3 vs lower LCn3 on risk of depression symptoms, sub-grouped by EPA dose. Supplementary Figure 4. Meta-analysis of effects of higher LCn3 vs lower LCn3 on risk of depression symptoms, sub-grouped by DHA dose. Supplementary Figure 5. Funnel plot of the analysis of effects of higher LCn3 vs lower LCn3 on risk of depression.Supplementary Figure 6. Meta-analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, analysed using SMD, sub-grouped by LCn3 dose. Supplementary Figure 7. Meta-analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, analysed using SMD, sub-grouped by EPA dose. Supplementary Figure 8. Meta-analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, analysed using SMD, sub-grouped by DHA dose. Supplementary Figure 9. Funnel plot of the analysis of effects of higher LCn3 vs lower LCn3 on depression symptoms, using SMD, sub-grouped by depression rating scale. Supplementary Figure 10. Forest plot of trials randomising to higher vs lower LCn3 intake and assessing depression symptoms (on a continuous scale) in those without depression at baseline, subgrouping by scale and displayed in native scales. For meta-analysis data were combined using SMD (not shown, SMD 0.01, 95% CI -0.06 to 0.07, I2 46%). Acknowledgements: This review is one of a set of reviews conducted by the PUFAH group. The Polyunsaturated Fats and Health (PUFAH) group includes Asmaa Abdelhamid1, Sarah Ajabnoor1, Faye Alabdulghafoor1, Lena Alkhudairy2, Priti Biswas3, Julii Brainard1, Charlene Bridges4, Tracey J Brown1, Katherine Deane3, Daisy Donaldson1, Sarah Hanson3, Lee Hooper1, Oluseyi Florence Jimoh1, Nicole Martin4, Alex O’Brien1, Karen Rees, Lena Alkhudairy2, Fujian Song1, Gabrielle Thorpe3, Xia Wang1 and Lauren Winstanley1. 1Norwich Medical School, University of East Anglia2Warwick Medical School, University of Warwick3 School of Health Sciences, University of East Anglia4Cochrane Heart Group, University College LondonSupplementary References ADDIN EN.REFLIST 1.Hooper L, Abdelhamid A, Brainard J, Deane KHO, Song F. Creation of a database to assess effects of omega-3, omega-6 and total polyunsaturated fats on health: database and methodology for a set of reviews. BMJ Open. 2019; 9(5): e029554. DOI: 10.1136/bmjopen-2019-0295542.Kromhout D, Giltay EJ, Geleijnse JM, Alpha Omega Trial Group. n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med. 2010; 363(21): 2015-26. 3.Chew EY, Clemons TE, Agron E, Launer LJ, Grodstein F, Bernstein PS, et al. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. JAMA. 2015; 314(8): 791-801. 4.ASCEND Study Collaborative Group. Effects of n?3 Fatty Acid Supplements in Diabetes Mellitus. N Engl J Med. 2018; 379(16): 1540-50. 10.1056/NEJMoa18049895.Derosa G, Cicero AF, D'Angelo A, Borghi C, Maffioli P. Effects of n-3 PUFAs on fasting plasma glucose and insulin resistance in patients with impaired fasting glucose or impaired glucose tolerance. BioFactors. 2016; 42(3): 316-22. 6.Danthiir V, Hosking D, Burns NR, Wilson C, Nettelbeck T, Calvaresi E, et al. Cognitive performance in older adults is inversely associated with fish consumption but not erythrocyte membrane n-3 fatty acids. J Nutr. 2014; 144(3): 311-20. 7.Vellas B, Carrie I, Guyonnet S, Touchon J, Dantoine T, Dartigues JF, et al. MAPT (multi-domain Alzheimer's prevention trial): Results at 36 months. Alzheimer's dement. 2015; 1): 331. 8.Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer's dement. 2010; 6(6): 456-64. 9.Pawelczyk T, Grancow-Grabka M, Kotlicka-Antczak M, Trafalska E, Pawelczyk A. A randomized controlled study of the efficacy of six-month supplementation with concentrated fish oil rich in omega-3 polyunsaturated fatty acids in first episode schizophrenia. J Psychiatr Res. 2016; 73: 34-44. 10.Rauch B, Schiele R, Schneider S, Diller F, Victor N, Gohlke H, et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation. 2010; 122(21): 2152-9. 11.Dangour AD, Allen E, Elbourne D, Fasey N, Fletcher AE, Hardy P, et al. Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr. 2010; 91(6): 1725-32. 12.Sinn N, Milte CM, Street SJ, Buckley JD, Coates AM, Petkov J, et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. Br J Nutr. 2012; 107(11): 1682-93. 13.Galan P, Kesse-Guyot E, Czernichow S, Briancon S, Blacher J, Hercberg S, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. Br Med J. 2010; 341: c6273. 14.Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, et al. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017; 16(5): 377-89. DOI: 10.1016/S1474-4422(17)30040-615.Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME, et al. The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(6): 1538-44. 16.Burr ML, Ashfield-Watt PA, Dunstan FD, Fehily AM, Breay P, Ashton T, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr. 2003; 57(2): 193-200. 17.Tokudome S, Kuriki K, Yokoyama Y, Sasaki M, Joh T, Kamiya T, et al. Dietary n-3/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: a randomized controlled trial in polypectomized participants. Prostaglandins Leukot Essent Fatty Acids. 2015; 94: 1-11. 18.Einvik G, Ekeberg O, Lavik JG, Ellingsen I, Klemsdal TO, Hjerkinn EM. The influence of long-term awareness of hyperlipidemia and of 3 years of dietary counseling on depression, anxiety, and quality of life. J Psychosom Res. 2010; 68(6): 567-72. 19.Sanyal AJ, Abdelmalek MF, Suzuki A, Cummings OW, Chojkier M, Group E. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology. 2014; 147(2): 377-84. 20.Ferreira JJ, Rosser A, Craufurd D, Squitieri F, Mallard N, Landwehrmeyer B. Ethyl-eicosapentaenoic acid treatment in Huntington's disease: A placebo-controlled clinical trial. Mov Disord. 2015; 30(10): 1426-9. 21.Hashimoto M, Kato S, Tanabe Y, Katakura M, Mamun AA, Ohno M, et al. Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes. Geriatr Gerontol Int. 2016; 17(2): 330-7. 22.Jackson PA, Forster JS, Bell JG, Dick JR, Younger I, Kennedy DO. DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults. Nutrients. 2016; 8: 86-. 23.Lee SP, Dart AM, Walker KZ, O'Dea K, Chin-Dusting JP, Skilton MR. Effect of altering dietary n-6:n-3 PUFA ratio on cardiovascular risk measures in patients treated with statins: a pilot study. Br J Nutr. 2012; 108(7): 1280-5. 24.Van De Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG, et al. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology. 2008; 71(6): 430-8. 25.McGorry PD, Nelson B, Markulev C, Yuen HP, Sch?fer MR, Mossaheb N, et al. Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders: The NEURAPRO Randomized Clinical Trial. JAMA Psychiatry. 2017; 74(1): 19-27. 26.Torkildsen O, Wergeland S, Bakke S, Beiske AG, Bjerve KS, Hovdal H, et al. omega-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial. Arch Neurol. 2012; 69(8): 1044-51. 27.Freund-Levi Y, Basun H, Cederholm T, Faxen-Irving G, Garlind A, Grut M, et al. Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms. Int J Geriatr Psychiatry. 2008; 23(2): 161-9. 28.Palma C. Omega 3 fatty acids supplementation in Schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2015; 265(Supplement 1): S122-S. 29.Pomponi M, Loria G, Salvati S, Di Biase A, Conte G, Villella C, et al. DHA effects in Parkinson disease depression. Basal Ganglia. 2014; 4(2): 61-6. 30.Pratt CM, Reiffel JA, Ellenbogen KA, Naccarelli GV, Kowey PR. Efficacy and safety of prescription omega-3-acid ethyl esters for the prevention of recurrent symptomatic atrial fibrillation: a prospective study. Am Heart J. 2009; 158(2): 163-9. 31.Tajalizadekhoob Y, Sharifi F, Fakhrzadeh H, Mirarefin M, Ghaderpanahi M, Badamchizade Z, et al. The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study. Eur Arch Psychiatry Clin Neurosci. 2011; 261(8): 539-49. 32.Tuttle KR, Shuler LA, Packard DP, Milton JE, Daratha KB, Bibus DM, et al. Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial). Am J Cardiol. 2008; 101(11): 1523-30. 33.Huntington Study Group. Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study. Arch Neurol. 2008; 65(12): 1582-9. 34.Geleijnse J, Giltay E, Kromhout D. Effects of n-3 fattyacids on cognitive decline: A randomized double-blind, placebo-controlled trial in stable myocardial infarction patients. Alzheimer's dement. 2011; 1): S512. 35.Estruch R, Ros E, Salas-Salvadó J, Covas M, Corella D, Arós F et al. Retraction and republication: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368:1279-90. N Engl J Med. 2018; 378: 25-. 36.Harbord RM, Egger M, Sterne JAC. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Statistics in Medicine. 2006; 25(20): 3443-57. DOI: 10.1002/sim.238037.Sterne JAC, Sutton AJ, Ioannidis JPA, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. Br Med J. 2011; 343: d4002. DOI: 10.1136/bmj.d400238.Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of Two Methods to Detect Publication Bias in Meta-analysis. JAMA. 2006; 295(6): 676-80. DOI: 10.1001/jama.295.6.67639.Page MJ, Higgins JPT, Sterne JAC. Chapter 13: Assessing risk of bias due to missing results in a synthesis. Draft version (29 Janaury 2019) for inclusion in. In: Cochrane Handbook for Systematic Reviews of Interventions (eds JPT HIggins, J Thomas, J Chandler, M Cumpston, T Li, MJ Page, et al.). Cochrane, 2019.40.Rauch B, Schiele R, Schneider S, Diller F, Victor N, Gohlke H, et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation. 2010; 122(21): 2152-9. 41.Van De Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Hoefnagels WH, Beekman AT, et al. Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2008; 88(3): 706-13. 42.Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018; 11: CD003177. DOI: 10.1002/14651858.CD003177.pub443.Abdelhamid AS, Martin N, Bridges C, Brainard JS, Wang X, Brown TJ, et al. Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018; 11: CD012345. DOI: 10.1002/14651858.CD012345.pub344.Hooper L, Al-Khudairy L, Abdelhamid AS, Rees K, Brainard JS, Brown TJ, et al. Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018; 11: CD011094. DOI: 10.1002/14651858.CD011094.pub445.Abdelhamid A, Hooper L, Sivakaran R, Hayhoe RPG, Welch A, The PUFAH Group. The Relationship Between Omega-3, Omega-6 and Total Polyunsaturated Fat and Musculoskeletal Health and Functional Status in Adults: A Systematic Review and Meta-analysis of RCTs. Calcified Tissue International. 2019. DOI: 10.1007/s00223-019-00584-346.Brainard J, Jimoh OF, Deane K, Biswas P, Donaldson D, Maas K, et al. Omega-3, omega-6 and total polyunsaturated fat for cognition and dementia: Systematic review and meta-analysis of RCTs. submitted. 2019. 47.Brown TJ, Brainard J, Song F, Wang X, Abdelhamid A, Hooper L. Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials. Br Med J. 2019; 366: l4697. DOI: 10.1136/bmj.l469748.Hanson S, Thorpe G, Winstanley L, Abdelhamid AS, Hooper L. Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials. submitted. 2019. 49.Thorpe G, Ajabnoor S, Ahmed Z, Abdelhamid A, Hooper L. Dietary polyunsaturated fat for prevention and treatment of inflammatory bowel disease. PROSPERO. 2017: CRD42017068704. 50.Burr ML, Ashfield-Watt PA, Dunstan FD, Fehily AM, Breay P, Ashton T, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr. 2003; 57(2): 193-200. 51.Cockayne NL, Duffy SL, Bonomally R, English A, Amminger PG, Mackinnon A, et al. The Beyond Ageing Project Phase 2--a double-blind, selective prevention, randomised, placebo-controlled trial of omega-3 fatty acids and sertraline in an older age cohort at risk for depression: study protocol for a randomized controlled trial. Trials. 2015; 16: 247. 52.Cai S, Coates AM, Buckley JD, Berry NM, Burres L, Beltrame J, et al. There is No Association Between the Omega-3 Index and Depressive Symptomsin Patients With Heart Disease Who Are Low Fish Consumers. Heart Lung Circ. 2017; 26: 276-84. 53.Bowman LG, Silbert CL, Dodge HH, Lahna D, Hagen K, Murchison FC, et al. Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results. Nutrients. 2019; 11(4). DOI: 10.3390/nu1104073554.Qurashi I, Chaudhry IB, Khoso AB, Farooque S, Lane S, Husain MO, et al. A randomised, double-blind, placebo-controlled trial of minocycline and/or omega-3 fatty acids added to treatment as usual for at-risk mental states (NAYAB): study protocol. Trials. 2017; 18(1): 524. DOI: 10.1186/s13063-017-2275-y55.Okereke OI, Reynolds CF, III, Mischoulon D, Chang G, Cook NR, Copeland T, et al. The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression. Contemp Clin Trials. 2018; 68: 133-45. DOI: 10.1016/t.2018.02.017 ................
................