DIRECTOR’S COMMENTS



Cardiovascular Sciences Collaborative Program

University of Toronto

Annual Activity Report 1994-1995

It gives me great pleasure to announce that the Cardiovascular Sciences Collaborative Program underwent its first 3 year review, and with the support of our faculty and students was resoundly endorsed for another 5 year term. I would like to thank everyone that has been involved with the Program from the very beginning as well as our new members on their continuing hard work and support.

The Cardiovascular Sciences Collaborative Program has had an extremely busy, productive, and successful year. Many changes and improvements took place at the University of Toronto and the Program also looked at ways of improving, whether it was with increased student enrolment or funding.

I look forward to the next 5 years and all that the Cardiovascular Sciences Collaborative Program can bring to the students, the faculty, and the university community.

Dr. C. Wittnich

Director

COLLABORATING DEPARTMENTS

Clinical: Department of Medicine

Department of Surgery

Graduate: Cellular and Molecular Pathology

Department of Clinical Biochemistry

Department of Community Health (Exercise Science Program)

Department of Pharmacology

Department of Physiology

Institute of Medical Science (IMS)

Other: The Centre for Cardiovascular Research

Institute of Biomedical Engineering (IBME) (new for 1994/95)

EXECUTIVE COMMITTEE

The Executive Committee consists of a representative from each collaborating department.

Dr. C. Wittnich (Director)

Dr. M. Plyley (Community Health)

Dr. A.I. Gotlieb (Pathology)

Dr. C. Forster (Pharmacology)

Dr. D.H. Osmond (Physiology)

Dr. R.D. Weisel (IMS)

Dr. C-C. Liew (Clinical Biochemistry)

Dr. M. Ojha (IBME)

COURSES OFFERED

BME1448H Cardiovascular Fluid Mechanics (Biomedical Engineering)

CHL4607H Cardiovascular Adaptations to Exercise and Environment (Community Health)

CHL3608H Ischemic Heart Disease and Physical Activity (Community Health)

CLB1407 From Bench to Bedside: Design, Measurement and Analysis for Clinical Investigators (Clinical Biochemistry)

CLB1504 Biochemistry, Molecular Biology of Cardiovascular Disease (Clinical Biochemistry)

CLB1503 Signal Transduction Pathways in Normal and Diseased Tissue (Clinical Biochemistry)

JEB1365H Ultrasound: Theory and Applications in Biology and Medicine

JTC1331 Biomaterials Science

MSC3060H* Advanced Research in Cardiovascular Sciences I (IMS)

MSC3061H* Advanced Research in Cardiovascular Sciences II (IMS)

PAT1015H Vascular Pathobiology (Pathology)

PCL1006Y Cardiovascular Pharmacology (Pharmacology)

PSL1029H Advanced Course in Cardiovascular Regulation (Physiology)

PSL1060H Developmental Cardiovascular Physiology (Physiology)

PSl1038H Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments (Physiology)

*Core Courses

For a Doctoral Degree, the student is required to take the full credit course MSC3060/3061 as well as fulfil the requirements of the home department.

For a Master’s Degree, the student is required to take a one-half course selected from the cardiovascular curriculum in addition to any specific requirements from the home department.

PROGRAM SPONSORED ACTIVITIES

Annual Cardiovascular Scientific Day - June 15, 1995

Because of the significant changes occurring in our healthcare system, it was decided that the annual University of Toronto - Centre for Cardiovascular Research Scientific Day would feature "The Impact of Health Care Reform on Research and Education in Cardiovascular Science". A number of outstanding speakers shared the platform. Dr. Charles Hollenberg, CEO, Ontario Cancer Treatment and Research Foundation, spoke on "An Overview of Health Care Reform", Dr. Alan Hudson, President and CEO of The Toronto Hospital, shared his views on "Strategic Options for the Teaching Hospitals" and Dean Arnie Aberman, Faculty of Medicine, University of Toronto, spoke on "Strategic Options for the University of Toronto". Two invited speakers, Dr. Eldon Smith, Dean, Faculty of Medicine, University of Calgary, gave the Isadore Edward Smith Lecture on "The Impact of Health Care Reform on Academic Medicine in Alberta" and Mr. Jeff Heseltine, Medical Director for Nordic Marion Merrell Dow Research, spoke on “Industrial-Academic Relationships”. A lively question period ensued! A number of breakout sessions were held in the morning and afternoon. Morning topics included sessions on Diabetes and Cardiovascular Disease as well as Featured Research which covered a spectrum from genetics to cultured cardiomyocytes as potential future treatment methods. Afternoon sessions included Nitric Oxide as the Molecule of the Decade and updates on New Therapeutic Approaches. As well there was a Nursing and Perfusion session.

A complimentary lunch allowed for faculty and student interactions and during this time posters were also presented. The following students were awarded prizes for their posters: lst Prize - J. Ikonomidis - "Ischemic" or adenosine preconditioning of human ventricular cardiomyocytes is protein kinase C dependent. 2nd Prize - M. Yang - Feasibility of RT-PCR to assess cardiac-specific gene expression in human myocardial biopsies: Sample variability. 3rd Prize (tied) - D.C.H. Cheng - Cost analysis of early vs conventional extubation post coronary artery bypass graft (CABG) surgery: A prospective randomized controlled study, and S.M. Torrance - Duration of ischemia is not the primary predictor of post-ischemic functional recovery in immature hearts.

CME credits (6.5) were issued for this meeting continuing the high quality of the scientific content. My thanks to industry for their continued financial support and generosity so essential to the success of this meeting.

Once again, the scientific day was a resounding success and continues to be the highlight of our academic year with well over 250 participants.

Heartline

In keeping with these times of financial constraint, it was decided to produce the newsletter using desktop publishing from our office. It was hoped that this format would allow for more cost effective and timely distribution of announcements and news. With cooperation from the various departments it was hoped that the newsletter would be produced on a quarterly basis. Should sponsorship become available a return to the original format would occur.

Inside the Heart Lecture Series

A number of interesting speakers contributed their time and knowledge to this lecture series and topics covered included an overview on cardiac muscle metabolism and function from all aspects including physiology, hemodynamic, and cellular to clinical. Additional emphasis was placed on a molecular biology approach and a series of lectures were held providing insight into not only the basics but how this technology can be used in current research on myocardial diseases.

Summer Activities

The Cardiovascular Sciences Collaborative Program, along with the Division of Cardiac Surgery, ran a very successful summer program. With the many applicants (high school, undergraduate, and medical school students), the Program was able to place 17 students with faculty. All of these students were funded by various agencies and, for the first year, the Program was awarded 5 Life Science Awards from the Faculty of Medicine.

ADVERTISING MATERIAL

An updated brochure and poster were created and circulated to reflect the new participating departments. The poster has a brighter look to encourage additional recruitment and promote dissemination of information to interested faculty and students. In addition, the Program also has a home page at the University of Toronto internet site and it is hoped that this will be expanded to include cross referencing with the participating departments and groups and more information on Program faculty.

Other material that gives the Program exposure is the brochure, Scientific Day pamphlet, and industry sponsored seminars.

PROGRAM FACULTY

The faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS status. Affiliate members participate in graduate training but do not, as yet, have SGS status.

FULL: U. Ackermann, C.E. Bayliss, D. Bradley, J. Edelson, J.S. Floras, C. Forster, A.I. Gotlieb, K.W. Johnston, P.G. Kalman, B.L. Langille, H. Lenskyj, C-C. Liew, P. Liu, P. McLaughlin, D.A.G. Mickle, L. Mickleborough, R.I. Ogilvie, M. Ojha, D.H. Osmond, M.J. Plyley, M. Rabinovitch, I. Rebeyka, N.A. Shaikh, I. Sherman, M.D. Silver, K. Skorecki, A.S. Slutsky, M.J. Sole, H. Sonnenberg, G. Steiner, P. Walker, R.D. Weisel, G. Wilson, C. Wittnich, T-W. Wu, E.L. Yeo

ASSOCIATE: J. Coles, E. Conway, J.M. Goodman, L.S. Goodman, J. Irvine, S.G. Thomas

AFFILIATE: A.G. Adelman, R.J. Burns, J. Butany, C.M. Feindel, G.F. Lewis, R-K. Li, T. Lindsay, J. Parker, L. Schwartz

RETIRED: Professor R.J. Shephard

PROGRAM STUDENTS

Student Supervisor Degree Department

Ms. Cathy Carlyle Dr. C. Wittnich MSc IMS

Dr. Bryce Cowan Dr. M. Rabinovitch PhD Pathology

Dr. Roberto Diaz Dr. G. Wilson MSc IMS

Dr. Ricardo Fontani Dr. G. Steiner MSc IMS

Ms. Kyle Harrow Dr. J. Goodman PhD Community Health

Dr. John Ikonomidis Dr. R. Weisel PhD IMS

Ms. Giulia Larosa Dr. C. Forster PhD Pharmacology

Dr. Vivek Rao Dr. R. Weisel MSc IMS

Ms. Shona Torrance Dr. C. Wittnich PhD IMS

Mr. Jack Wallen Dr. C. Wittnich MSc Physiology

Dr. Sonia Yovtcheva Dr. D. Osmond MSc Physiology

CONVOCATED STUDENTS/FOLLOW-UP

Dr. Silvana Molossi (Supervisor: Dr. M. Rabinovitch) obtained her PhD through the Department of Pathology in 1994. Silvana has since returned to her native country of Brazil and will continue her work as a doctor and researcher.

STUDENT ACHIEVEMENTS

C. Carlyle Open Scholarship, Univ of Toronto

SGS Tuition Bursary, Univ of Toronto

B. Cowan Heart & Stroke Foundation of Canada Research Traineeship

George Brown Award for Excellence in Basic Science Research, Univ

of Toronto, Faculty of Medicine Research Day

1st Annual Robert Disenhouse Cardiac-Science Competition and

Memorial Lecture

R. Diaz Open Scholarship, Univ of Toronto

K. Harrow Open Doctoral Fellowship, Univ of Toronto

G. Larosa Ontario Graduate Scholarship

Open Doctoral Fellowship, Univ of Toronto

Research Travel Award, American Society of Pharmacology and

Experimental Therapeutics

V. Rao Heart & Stroke Foundation of Ontario Research Fellowship

Pharmaceutical Roundtable Research Fellowship

S. Torrance Heart & Stroke Foundation of Canada Research Traineeship

Medtronic Travel Award, Cardiovascular Sciences Collaborative

Program, Univ of Toronto

Runner-up, Margaret McWilliams Pre-Doctoral Fellowship, Canadian

Federation of University Women

Dan Roncari Book Prize, Institute of Medical Science, Scientific Day,

Univ of Toronto

3rd Prize, Poster Competition, Annual Cardiovascular Scientific Day,

Univ of Toronto

J. Wallen The Centre for Cardiovascular Research Student Fellowship

S. Yovtcheva Open Masters Fellowship, Univ of Toronto

Medtronic Travel Award, Cardiovascular Sciences Collaborative

Program, Univ of Toronto

DIRECTOR’S COMMENTS

With the review and renewal of the Program, the Executive Committee also confirmed their renewal for another term. As well, the Director was renewed for an additional 5 year term.

This year, again, student enrolment increased (6 Master’s and 5 PhD trainees). It is clear that every year the number of students enrolled in our program increases. However, the focus of this upcoming year will be to increase student awareness of the Program and its potential benefits. Concern has been raised from some quarters regarding our "low" student enrollment. It should be pointed out that it is the feeling of this Director that it is the quality of the student and not the quantity that counts. With annual student meetings, consultations, and feedback, it is clear that there is a high satisfaction rate with the current participating students. However, it is acknowledged that now that the Program has received its 5 year endorsement this would be an appropriate time to increase recruitment of appropriate candidates.

One way of encouraging students to enroll is through course MSC3060/3061 which continues to undergo restructuring and improvement. There is now a selection of basic and clinical subject areas which will be covered in a cyclical fashion across a 2 year period. This will allow students to select 2 of approximately 4 options, most relevent to their area of study. As this particular course is meant to be current topics in research it is also important that these be frontline subject areas relevent to the moment.

In order to better meet the needs of our students a reading/student room was created adjoining the Program office at the FitzGerald Building. This has met with enthusiastic support from both faculty and students. With space at a premium in the Medical Sciences Bldg., areas for small group get-togethers is becoming more and more difficult to find. The reading/student room provides a milieu for interaction and discussion of common interests and goals within the Program. A computer with internet access will eventually be available for common use.

With the cooperation and assistance of Marion Merrell Dow Canada, plans are progressing for setting up an internet web site for both faculty and students. This will link us with other cardiovascular groups not only on campus but at other centres and across the country/world. It is clear that the university is rapidly moving to electronic methods of communication and with the cooperation of all faculty the Program will endeavour to provide notices, newsletters, and correspondence via e-mail circulation as much as possible. This will also cut down on time and cost and facilitate more rapid information sharing among the Program faculty and students.

A formal recognition of students completing the Program is done every year at the Annual Cardiovascular Scientific Day. The graduates are recognized with a "Program Certificate" and a book entitled "Pioneers of Cardiology in Canada 1920-1970". The donation of this book has been provided by the Canadian Cardiovascular Society on an annual basis in recognition of our Program graduates.

The Medtronic Travel Award has become an ongoing annual competition and a number of meritorious cardiovascular students have benefited from this fund. This has offset expenses of students attending national or international meetings where their research work has been presented.

There has been significant effort on the part of the Director to ensure external and industry funding to cover the operating expenses of the Program. This was the first year that the majority of Program expenses were covered - thanks in large part to the generousity of Pfizer Canada - and it is hoped that with the continued support of our corporate sponsors this will be assured in the future.

The W.G. Bigelow book prize was established for outstanding research done by a graduate student enrolled in the Program. The inaugural awardee was Dr. John Ikonomidis who recently completed his PhD entitled "Preconditioning Human Ventricular Cardiomyocytes" under the supervision of Dr. Richard Weisel from the Department of Surgery and Institute of Medical Science. John did his research at the Centre for Cardiovascular Research.

For the 1995-96 academic year, we plan to continue the above activities along with the plans and priorities listed below:

1. Agressive student recruitment campaign.

2. Expanding and setting up the World Wide Web site.

3. Bridge funding for Program students.

4. Working toward a permanent financial base support.

5. Developing the 2 year curriculum for MSC3060/3061.

6. Establish invited lectureships (4 per year).

PUBLICATIONS - STUDENTS

Tsao PW, Mills GB, Diaz RJ, Radde IC, Martell MF, Augustinie JM, Parkinson D, Waddell J, Wilson GJ, Coles JG: Evidence that increases in lymphocyte tyrosine phosphrylation precede cardiac allograft rejection. Transplantation 58:451-457, 1994.

Larosa G, Armstrong PW, Forster C: Endothelium-dependent relaxations in canine coronary arteries are enhanced in early heart failure and persist in recovery. Can J Physiol Pharmacol 72:1148-1154, 1994.

Rao C, Rao V, Heggtveit HA, King DL: Sudden death due to coronary artery anomalies. Case report and clinical review. J. Forensic Sciences 39(1):246-252, 1994.

Christakis GT, Fremes SE, Koch JP, Harwood S, Juhausz S, Sharpe E, Deemar K, Hamilton C, Chen E, Rao V, Chang G, Goldman BS: Determinants of low systemic vascular resistance during cardiopulmonary bypass. Ann Thorac Surg 58:1040-1049, 1994.

Komeda M, David TE, Rao V, Sun Z, Weisel RD, Burns RJ: Late hemodynamic effects of the preserved papillary muscles during mitral valve replacement. Circulation 90(2):II190-II194, 1994.

Torrance SM, Wittnich C: Blood lactate and acid-base balance in graded neonatal porcine hypoxia: Evidence for oxygen-restricted metabolism. J Appl Physiol 77:2318-2324, 1994.

PUBLICATIONS - FACULTY

Aimone E, Thomas SG, Smith AW, McConnell SG: The stability of physiologic responses to a stair stepping task in healthy older women. Proc of 10th Commonwealth and International Science Conference. (Eds. F.I. Bell, G.H. Van Gyn) p209-214, 1994.

Aoyagi Y, McLellan T, Shephard RJ: Skin temperature during exercise in the heat: Effects of endurance training, heat acclimation and protective clothing. Can J Appl Physiol 19(S):1P, 1994.

Awerbuck D, McKee NH, Luong V, Plyley MJ: Skeletal muscle form and function after 4 hr ischemia-hypothermia. J Surg Res 57:480-486, 1994.

Baroldi G, Silver MD: Sudden death in ischemic heart disease. Austin TX: Landes Publishers, 1995.

Batsford WP, Mickleborough LL, Elefteriades JA: Ventricular arrhythmias in heart failure. IN: Cardiology Clinics Vol 13 #1; Advanced Treatment Options for the Failing Left Ventricle (Ed.) M.H. Crawford. W.B. Saunders, Philadelphia Company, pp87-91, 1995.

Beanlands RSB, Shaikh NA, Wen WH, Dawood F, Ugnat AM, McLaughlin PR, Carere R, Liu P: Alterations in fatty acid metabolism in adriamycin cardiomyopathy. J Mol Cell Cardiol 26:109-119, 1994.

Belik J, Keeley FW, Baldwin F, Rabinovitch M: Pulmonary hypertension and vascular remodelling in the fetal sheep. Am J Physiol 266 (Heart Circ Physiol35):H2303-H2309, 1994.

Bluechardt MS, Wiener J, Shephard RJ: Exercise programmes in the treatment of children with learning disabilities. Sports Med 19:55-72, 1995.

Bluechardt M, Shephard RJ: Using an extracurricular physical activity program to enhance social skills. J Learning Disabilities 28:160-169, 1995.

Brenner IKM, Shek PN, Shephard RJ: Heat exposure and immune function: Potential contribution to the exercise response. Ex. Immunol Rev. 1:49-80, 1995.

Buch S, Han R, Liu J, Moore A, Edelson JD, Freeman BA, Post M, Tanswell K: Basic fibroblast growth factor and growth factor receptor gene expression in 85% 02-exposed rat lung. Am J Physiol 269 (Lung Cell Mol Physiol12): L455-L464, 1995.

Buch S, Jassal D, Caniggia I, Edelson J, Han R, Liu J, Tanswell AK, Post M: Ontogeny and regulation of platelet-derived growth factor gene expression in distal fetal rat lung epithelial cells. Am J Respir Cell Biol 11:251-261, 1994.

Buchman T, Slutsky AS: (Co-editors) The Science and Practice of Acute Medicine. New Horizons 3(2), 1995.

Bulley SR, Wittnich C: Adenosine infusion: A rational approach toward induced hypotension. Can J Cardiol 11(4):327-334, 1995.

Burns RJ, Iles S, Fund A, Wright LM, Daigneault L: The Canadian exercise technetium-99m teboroxime SPECT study. J Nucl Cardiol 2:117-125, 1995.

Burns RJ: Technetium-99m teboroxime: death in utero, infanticide, or failure to thrive? (editorial) J Nucl Cardiol 2:88-91, 1995.

Butler GC, Senn BL, Floras JS: Influence of atrial natriuretic factor on spontaneous baroreflex sensitivity for heart rate in humans. Hypertension 25:1167-1171, 1995.

Butler G, Naughton MT, Rahman A, Senn B, Benard D, Bradley TD, Floras JS: Acute effects of continuous positive airway pressure on heart rate variability in congestive heart failure. J Am Coll Cardiol 25:672-679, 1995.

Christie NA, Slutsky AS, Freeman BA, Tanswell AK: A critical role for Thiol, but not ATP, depletion in 95% 02-mediated injury of preterm pneumocytes in vitro. Archives of Biochemistry and Biophysics 313:131-138, 1994.

Christie NA, Smith DE, DeCampos KN, Slutsky AS, Patterson GA, Tanswell AK: Lung oxidant injury in a model of lung storage and extended reperfusion. Am J Resp and Crit Care Med 150:1032-1037, 1994.

Clausell N, DeLima VA, Molossi S, Liu P, Turley E, Gotlieb AI, Adelman AG, Rabinovitch M: Expression of tumor necrosis factor alpha and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy. Br Heart J 1995.

Compeau CG, Ma J, DeCampos KN, Waddell TK, Brisseau GF, Slutsky AS, Rotstein OD: In situ ischemia and hypoxia enhance alveolar macrophage tissue factor expression. Am J Resp Cell Molecular Biol 11:446-455, 1994.

Conway EM, Liu L, Nowakowski B, Steiner-Mosonyi M, Jackman RW: Heat shock of vascular endothelial cells induces an upregulatory transcriptional response of the thrombomodulin gene that is delayed in onset and does not attenuate. J Biol Chem 269:22804-22810, 1994.

Conway EM, Liu L, Nowakowski B, Steiner-Mosonyi M, Ribeiro SP, Michalak M: Heat shock sensitive expression of calreticulin: In vitro and in vivo upregulation. J Biol Chem 270:17011-17016, 1995.

Conway EM, Nowakowski B, Steiner-Mosonyi M: Thrombomodulin lacking the cytoplasmic domain efficiently internalizes thrombin via non-clathrin coated pit mediated endocytosis. J Cell Phys 158:285-298, 1994.

Conway EM, Yeo EL: Thrombotic thrombocytopenia purpura. Conn's Current Therapy, W.B. Saunders Co., 1995.

Cott CA, Finch E, Gasner D, Yoshida K, Thomas SG, Verrier MC: The movement continuum theory of physical therapy. Physiotherapy Canada 47(2):87-95, 1995.

Daneman D, Crompton CH, Balfe JW, Sochett EB, Chatzilias A, Cotter BR, Osmond DH: Plasma prorenin as an early marker of nephropathy in diabetic (IDDM) adolescents. Kidney International 46:1154-1159, 1994.

David TE, Feindel CM, Bos J: Repair of the aortic valve in patients with aortic insufficiency and aortic root aneurysm. J Thor Cardiovasc Surg 109:345-352, 1995.

David TE, Feindel CM, Bos J, Sun Z, Scully HE, Rakowski H: Aortic valve replacement with a stentless porcine aortic valve - a six year experience. J Thor Cardiovasc Surg 108:1030-1036, 1994.

De Hoyos A, Liu PP, Benard DC, Bradley TD: Hemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function. Clin Sci 88:173-178, 1995.

Elefteriades JA, Solomon LW, Mickleborough LL, Cooley DA: Left ventricular aneurysmectomy in advanced left ventricular dysfunction. IN: Cardiology Clinics Vol 13 #1; Advanced Treatment Options for the Failing Left Ventricle. (Ed.) M.H. Crawford W.B. Saunders, Philadelphia Co., pp59-72, 1995.

Epp TA, Wang RX, Sole MJ, Liew CC: Concerted evolution of mammalian cardiac myosin heavy chain genes. J Mol Evol 41:284-292, 1995.

Ettenson DS, Gotlieb AI: Basic fibroblast growth factor is a signal for the initiation of centrosome redistribution to the front of migrating endothelial cells, at the edge of an in vitro wound. Arterioscler Thromb Vasc Biol 15:515-521, 1995.

Ettenson D, Gotlieb AI: Dysfunctional re-endothelialization: Wounds with disruption of migration repair primarily by cell proliferation. Microvascular Res 48:328-337, 1994.

Feher JJ, Rebeyka IM: Rapid cooling and pH jump-induced calcium release from isolated cardiac sarcoplasmic reticulum. Am J Physiol 267:H962-H969, 1994.

Fernandes ALG, Molfino NA, McLean P, Silverman F, Tarlo S, Raizenne M, Slutsky AS, Zamel N: The effect of pre-exposure to 0.12 ppm of ozone on exercise-induced asthma. Chest 106:1077-1082, 1994.

Forster C: Peripheral vascular contractility and protein kinase C in pacing-induced heart failure. Can J Physiol Pharmacol 73:651-660, 1995

Fremes SE, Guo L-R, Furukawa RD, Mickle DAG, Weisel RD: Cardiac storage with UW solution and glucose. Ann Thorac Surg, 58:1368-1373, 1994.

Fung YW, Wang RX, Heng HHQ, Liew CC: Mapping of a human LIM protein (CLP) on human chromosome 11p15.1 by fluorescence in situ hybridization. Genomics 28:602-602, 1995.

Fyfe AI, Rosenthal A, Gotlieb AI: Immunosuppresive agents and endothelial repair: prednisolone delays migration and cytoskeletal rearrangement in wounded porcine aortic monolayers. Arterioscler Thromb Vas Biol 15:1166-1171, 1995.

Gannon GA, Shek PN, Shephard RJ: Natural killer cells: Modulation by intensity and duration of exercise. Ex Immunol Rev 1:1-25, 1995.

Gibson WGR, Cobbold RSC, Johnston KW: Principles and design feasibility of a Doppler ultrasound intravascular volumetric flowmeter. IEEE Trans-Biomed Engineering 41:898-908, 1994.

Glynn MFX, Johnston KW: Perioperative hemorrhage. IN: Vascular Surgery, 4th Edition. (Ed.) R. Rutherford, W.B. Saunders Publishers, Philadephia, 1994.

Goodman J: Exercise and cardiac sudden death: Etiology in apparently healthy individuals. Sport Sci Rev 4(2):14-30, 1995.

Goodman LS, Goodman JM, Hsia TW, Freeman MR: Measurement of left ventricular function during arm ergometry using the VEST nuclear probe. Can J Appl Physiol 19(4):462-471, 1994.

Goodman LS, McKenzie DC, Nath CR, Schamberger W, Taunton JE, Ammann WC: Central adaptations in walking and jogging vs. aerobic circuit-trained cardiac patients. Can J Appl Physiol 20(2):179-198, 1995.

Hamsten A, Steiner G: Non-insulin-dependent diabetes mellitus and atherosclerosis: A lipoprotein perspective. J Inter Med 236(Supp.736):1-3, 1994.

Hara K, Floras JS: Influence of naloxone on muscle sympathetic nerve activity, hemodynamics and ambulatory blood pressure after exercise: Evidence for impaired opioidergic response to exercise in young subjects with mild essential hypertension. J Hypertension 13:447-461, 1995.

Hara K, Senn BL, Floras JS: Evaluation of acute haemodynamic response to high dose naloxone in young hypertensive and normotensive humans. Clin Invest Med 18:108-113, 1995.

Harrison DA, Benson LN, Cusimano RJ, McLaughlin PR: Right-to-left shunt following repair of partial anomalous pulmonary venous connection: A novel use of the rashkind double-umbrella occlusion device. Catheterization and Cardiovasc Diagnosis 33:356-360, 1994.

Hayashida N, Ikonomidis JS, Weisel RD, Shirai T, Ivanov J, Carson S, Mohabeer MK, Tumiati LC, Mickle DAG: The optimal cardioplegic temperature. Ann Thorac Surg 58:961-971, 1994.

Hayshida N, Weisel RD, Shirai T, Ikonomidis JS, Ivanov J, Carson S, Mohabeer MK, Tumiati LC, Mickle DAG: Tepid antegrade and retrograde cardioplegia. Ann Thorac Surg, 59:723-729, 1995.

Hill AB, Kalman PG, Johnston KW, Vosu HA: Reversal of delayed-onset paraplegia following thoracic aortic surgery with CSF drainage. J Vasc Surg 20:315-317, 1994.

Hirai T, Waddell TK, DeCampos KN, Compeau CG, Wada H, Hitomi S, Patterson GA, Slutsky AS: A short course of FK 506 can induce donor-specific graft acceptance. Ann Thoracic Surg 58:496-501, 1994.

Honrath U, Chong CK, Wilson DR, Sonnenberg H: Dietary salt extremes and kidney function in rats: Effect of atrial natriuretic factor. Clin Sci 87:525-531, 1994.

Huang WY, Cukerman E, Liew CC: Identification of a GATA motif in the cardiac α-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA. Gene 155(2):219-223, 1995.

Hwang DM, Hwang WS, Liew CC: Single pass sequencing of a unidirectional human fetal heart cDNA library to discover genes of the cardiovascular system. J Mol and Cell Cardiol 26:1329-1333, 1994.

Ikonomidis JS, Weisel RD, Hayashida N, Shirai T: Myocardial protection for coronary artery bypass surgery: Past, present and future. Asia Pacific J Thorac Cardiovasc Surg 3(2):69-76, 1994.

Ikonomidis JS, Tumiati LC, Weisel RD, Mickle DAG, Li R-K: Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischemia. Cardiovascular Res 28:1285-1291, 1994.

Irvine MJ, Ritvo PG, Katz J, Shaw BF: Maximizing adherence with non-pharmacological treatment. Can J Cardiol (Pfizer Suppl.)6-8, 1994.

Johnston KW: Influence of sex on the results of abdominal aortic aneurysm repair. J Vasc Surg 20:914-926, 1994.

Johnston KW: Percutaneous arterial dilatation for atherosclerotic lower extremity occlusive disease: Current therapy. IN: Vascular Surgery, 3rd Edition. (Ed.) C.B. Ernst , J.C. Stanley. Mosby-Year Book, Inc. Publishers, Philadelphia, PA. pg 512-517, 1995.

Johnston KW: Common complications of vascular surgery: Prevention and management - an overview. IN: Vascular Surgery, 4th Edition. Ed. R. Rutherford, W.B. Saunders Publishers, Philadephia, pg 522-528, 1994.

Johnston KW: Results of a multi-centre prospective study of abdominal aortic aneurysm repair. Proceedings of the Workshop on the Control of Abdominal Aortic Aneurysm 15(4):S42-43, 1994.

Johnston KW: Neurovascular conditions - an overview. IN: Vascular Surgery, 4th Edition. (Ed.) R. Rutherford, W.B. Saunders Publishers, Philadephia, 1994.

Johnston KW: Nonruptured abdominal aortic aneurysm: 6 year follow-up results from the multicenter prospective Canadian aneurysm study. J Vasc Surg 20:163-170, 1994.

Johnston KW, Kalman P, Walker P, Lindsay T, Rubin B: Mesenteric arterial bypass grafts-early and late results and suggested surgical approach for chronic and acute mesenteric ischemia. Surgery, 1995.

Johnston KW: Late results of operative abdominal aortic aneurysm repair: The surgical results from the Canadian cooperative Aneurysm Study. IN: Current Critical Problems in Vascular Surgery, Volume 6. (Ed.) FJ Veith. Quality Medical Publishers, St. Louis, MO, pgs 241-244, 1994.

Kakis G, Powell M, Marshall A, Woutersz TB, Steiner G: A two-year clinical study of the effects of two triphasic oral contraceptives on plasma lipids. Internat J Fertil 39(5):283-291, 1994.

Kalman P, Johnston KW, Walker P, Lindsay T: Preoperative factors that predict hospital length of stay after distal arterial bypass. J Vasc Surg 20(1):70-75, 1994.

Kalman PG: The challenge in management of thoracoabdominal aneurysms. Perspectives in Cardiology 10:33-40, 1994.

Kalman PG, Johnston KW: Aortoiliac occlusive disease. IN: General Surgery. (Ed.) W.P. Ritchie, Jr., G. Steele, Jr., R.H. Dean. JB Lippincott, Philadelphia, pg 643-653, 1995.

Kirkcaldy BD, Cooper CL, Shephard RJ, Brown JS: Exercise, job satisfaction and well-being among superintendent police officers. Eur Rev Appl Psychol 44:117-123, 1994.

Komeda M, David TE, Rao V, Weisel RD, Burns RJ: Late hemodynamic effects of the preserved papillary muscles. Circulation 90:II190-II194, 1994.

Koppel R, Han R, Cox D, Tanswell K, Rabinovitch M: Alpha 1-antitrypsin protects neonatal rats from pulmonary vascular and parenchymal effects of oxygen toxicity. Pediatr Res 36:763-770, 1994.

Langille BL, Gotlieb AI: Arterial remodeling in response to altered blood flow. IN: Atherosclerosis. (Eds.) X. F. Woodford, J. Davignon, A. Sniderman. Elsevier, Amsterdam, 1995.

Langille BL: Blood flow-induced remodelling of the artery wall. IN: Flow-Dependent Regulation of Vascular Function. (Ed.) G. Kaley, J. Bevan, G. Rubanyi. Oxford, New York, 1995.

Langille BL, Gotlieb AI: Arterial remodeling in response to altered blood flow. Proceedings of the XI International Symposium on Atherosclerosis, Montreal, 1994.

Larosa G, Armstrong PW, Forster C: Endothelium-dependent relaxations in canine coronary arteries are enhanced in early heart failure and persist in recovery. Can J Physiol Pharmacol 72:1148-1154, 1994.

Lewis GF, Steiner G, Polonosky KS, Weller B, Zinman B: A new method for comparing portal and peripheral venous insulin delivery in humans: Tolbutamide vs. insulin infusion. J Clin Endocin & Metab 79:66-70, 1994.

Lewis GF, Zinman B, Uffelman KD, Szeto L, Weller B, Steiner G: VLDL production is decreased to a similar extent by acute portal and systemic hyperinsulinemia in humans. Am J Physiol 267:E566-E572, 1994.

Lewis GF, Uffelman KD, Szeto L, Weller B, Steiner G: Interaction between free fatty acids (FFA) and insulin in the acute control of very low density lipoprotein (VLDL) production in humans. J. Clin Invest 95:158-166, 1995.

Lewis GF, Ralevski E, Neitzert CS, Uffelman KD, Steiner G, Kennedy SH: Lipids and lipoproteins in anorexia nervosa before and after weight restoration. Endocrinology and Metabolism 1:109-115, 1994.

Liew CC, Hwang DM, Fung YW, Laurenssen C, Cukerman E, Lee CY: A catalogue of genes in the cardiovascular system as identified by expressed sequence tags (ESTs) Proc Natl Acad Sci USA 91:10645-10649, 1994.

Lindsay TF, Rubin BB, Romaschin AD, Walker PM: Complement Activation. IN: Ischemia-Reperfusion Injury of Skeletal Muscle. (Ed.) G.A. Fantini. R.G. Landes Company, Biomedical Publishers, Austin. 5:77-92, 1994.

Lindsay TF: The in vivo gracilis muscle model of skeletal muscle ischemia. J Invest Surg 7(1):17-26, 1994.

Lockhart A, Slutsky AS: Furosemide and loop diuretics in human asthma. Chest 106:244-249, 1994.

Longmuir P, Shephard RJ: Reliability and validity of a modified Canadian Aerobic Fitness Test for individuals with mobility impairments. Adapted Phys Activ Quart 12:161-175, 1995.

Maingi M, Glynn MFX, Scully HE, Graham AF, Floras JS: Spontaneous spinal epidural hemotoma in a patient with a mechanical aortic valve taking warfarin. Can J Cardiol 11:429-432, 1995.

Maniatis TA, Cobbold RSC, Johnston KW: Flow imaging in an end-to-side anastomosis model using two-dimensional velocity vectors. Ultrasound in Med & Biol 20:559-569, 1994.

Martino TA, Liu P, Sole MJ: Viral infection and the pathegenesis of dilated cardiomyopathy: Time to revisit the virus. Heart Failure 9:218-226, 1994.

Maruyama H, Mickleborough LL, Szwarc R, Wilson GJ, Mohamed S: A new canine model of left ventricular dysfunction due to regional infarction. Surgical Forum Vol XLV:235-236, 1994.

Mertens DJ, Kavanagh T, Shephard RJ: A simple formula for the estimation of maximal oxygen intake during cycle ergometry. Eur Heart J 15:1247-1251, 1994.

Mickleborough LL, Maruyama H, Mohamed S, Rappaport DC, Downar E, Butany J, Sun Z: Are patients on Amiodarone at increased risk for cardiac surgery? Ann Thor Surg 58:622-629, 1994.

Mickleborough LL, Mizuno S, Usui A, Wilson GJ, McComb D, Gray G: Balloon electric shock ablation. A surgical technique for treatment of ventricular tachycardia: Influence of endocardial scar on depth of ablation. J Thoracic Cardiovasc Surg 108(5):855-861, 1994.

Molfino NA, Nannini LJ, Chapman KR, Slutsky AS: Trends in pharmacotherapy for chronic airflow limitation in Argentina: 1983-1990. Medicina (Buenos Aires) 55:103-109, 1994.

Molossi S, Elices M, Arrhenius T, Diaz R, Coulber C, Rabinovitch M: Blockade of VLA-4 integrin binding to fibronectin with CS1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. J Clin Invest 95:2601-2610, 1995.

Molossi S, Clausell N, Rabinovitch M: Reciprocal induction of tumor necrosis factor-α and interleukin-1β activity mediates fibronectin synthesis in coronary artery smooth muscle cells. J Cell Physiol 163:19-29, 1995.

Muscedere J, Zamel N, Slutsky AS: Physiology. IN: Thoracic Surgery, 1st (Ed.) F.G. Pearson. Churchill Livingstone, New York 4:37-56, 1995.

Nantias T, Pepper J, Aimone E, Vaughan J, Tonack M, Plyley M: A manual wheelchair exercise devise with powered assistance. Proceedings of the Rehabilitation Engineering Society of North America, pg 9-13, June 1995.

Naughton MT, Rahman A, Hara K, Floras JS, Bradley TD: Effects of continuous positive airway pressure on intrathoracic and left ventricular transmural pressure in congestive heart failure. Circulation 91:1725-1731, 1995.

Naughton MT, Benard DC, Rutherford R, Bradley TD: Effect of continuous positive airway pressure on central sleep apnea and nocturnal PCO2 in heart failure. Am J Resp Crit Care Med 150:1598-1604, 1994.

Naughton MT, Liu PP, Benard DC, Goldstein RS, Bradley TD: Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure. Am J Respir Crit Care Med 151:92-97, 1995.

Nekooeian AA, Ogilvie RI, Zborowska-Sluis D: Acute hemodynamic effects of drugs acting on the renin-angiotensin system in acute heart failure. Can J Cardiol 11:59-64, 1995

Noreau L, Shephard RJ: Guarding against pitfalls in multivariate analysis. An illustration from fitness testing of the spinally injured. J Sports Med Phys Fitness 34:192-198, 1994.

Ogilvie RI, Zborowska-Sluis D: Effect of captopril treatment on total and central vascular capacitance in dogs with chronic heart failure. J Cardiovasc Pharmacol 24:358-364, 1994.

Olivieri NF, Brittenham GM, Matsui D, Berkovitch M, Blendis LM, Liu P, et al: Iron-chelation therapy with oral deferipronein patients with thalassemia major. N Engl J Med 331:918-922, 1995.

Olivieri NF, Nathan D, Liu P, et al: Survival in medically treated beta-thalassemia. N Engl J Med 331:574-578, 1994.

Pang KS, Sherman IA, Xu N, Schwab AJ, Barker III F, Dlugosz JA, Cuerrier G, Goresky CA: Role of the hepatic artery in the metabolism of phenacetin and acetaminophen: An intravital microscopic and multiple indicator dilution study in perfused rat liver. Hepatology 20:672-683, 1994.

Parker JD, Parker AB, Farrell B, Parker JO: Intermittent transdermal mitroglycerin therapy: Decreased anginal threshold during the nitrate free interval. Circulation 91:973-978, 1995.

Petrasek P, Lindsay T, Romaschin A, Walker P: Delayed activation of neutrophil Cdl8 after acute skeletal muscle ischemia - evidence for a mechanism of late local or systemic injury. J Vasc Surg, 1994.

Rhind SG, Shek PN, Shinkai S, Shephard RJ: Differential expression of interleukin-2 receptor alpha and beta chains in relation to natural killer cell subsets and aerobic fitness. Int J Sports Med 15:911-918, 1994

Rhind SG, Shek PN, Shephard RJ: The impact of exercise on cytokines and receptor expression. Ex Immunol Rev 1:97-149, 1995.

Ribeiro SP, Villar J, Slutsky AS: Induction of the stress response to prevent organ injury. New Horizons 3(2):301-311, 1995.

Ritvo PG, Irvine MJ, Katz J, Shaw BF: Quality of life and prostate cancer treatment: Decision making and rehabilitative support. Can J Onc 4(Supp 1):S43-46, 1994.

Rode A, Shephard RJ: Growth and fitness of Canadian Inuit: Secular trends. Am J Human Biology 6:525-541, 1994.

Rode A, Shephard RJ: Prediction of body fat content in the Inuit. Ibid pp.230-232, 1995.

Rode A, Shephard RJ: Physiological consequences of acculturation: A 20-year study of fitness in an Inuit community. Ibid, pp.218-221, 1995.

Rode A, Shephard RJ: Physiological consequences of acculturation: A 20-year study of fitness in an Inuit community. Eur J Appl Physiol 69:516-524, 1994.

Rode A, Shephard RJ: Aging of lung function. Cross-sectional and longitudinal trends in an Inuit community. Ibid pp.233-237, 1995.

Rode A, Shephard RJ, Vloshinsky PE, Kuksis A: Plasma fatty acid profiles of Canadian Inuit and Siberian Ganasan. Arct Med Res 54:10-20, 1995.

Rode A, Shephard RJ: Secular and age trends in the height of adults in a Canadian Inuit community. Ibid pp.226-229, 1995.

Rode A, Shephard RJ: Growth and development of Canadian Inuit. Secular trends 1970 to 1990. Ibid, pp.222-225, 1995.

Rode A, Shephard RJ: The aging of lung function: Cross-sectional and longitudinal studies of an Inuit community. Eur Respir J 7:1653-1659, 1994.

Rode A, Shephard RJ: Acculturation and growth of lung function: Three cross-sectional surveys of an Inuit community. Respiration 61:187-194, 1994.

Ross DB, Trusler GA, Coles JG, Rebeyka IM, Smallhorn J, Williams WG, Freedom WG: Small aortic root in childhood: surgical options. Ann Thorac Surg 55:1617-1625, 1994.

Schwartz L: Coronary stent placement with balloon angioplasty. N Eng J Med 332:536-537, 1995.

Shaw-Stiffel TA, Walker SE, Ogilvie RI, Leenen FH: Pharmacokinetic and pharmacodynamic interactions during multiple-dose administration of nisoldipine and propranolol. Clin Pharmacol Therap 55:661-669, 1994.

Shephard RJ: Review essay: A personal perspective on aging and productivity, with particular reference to physically demanding work. Ergonomics 38:617-636, 1995.

Shephard RJ, Shek PN: Exercise, aging and immune function. Int J Sports Med 16:1-6, 1995.

Shephard RJ: The therapeutic value of exercise. Parkhurst Exchange 3(4):77-79, 1995.

Shephard RJ: Ejercicio, envejecimiento y calidad de vida. Ibid pp.29-39, 1995.

Shephard RJ: Physiological basis of training in the elderly. Science & Sports 9:189-196, 1994.

Shephard RJ, Shek PN: Potential impact of physical activity and sport on the immune system: A brief review. Br J Sports Med 28:247-255, 1994.

Shephard RJ: Costos y benificia de una scoiedad deportiva versus una sociedad sedentaria. Ibid pp.15-26, 1995.

Shephard RJ, Kavanagh T, Campbell R, Lorenz B: Net energy costs of ambulation in normal subjects and subjects with lower limb amputations. Can J Rehab 8:97-108, 1995.

Shephard RJ: Book reviews: Guidelines for Cardiac Rehabilitation (AACVPR); Heart Disease and Rehabilitation. (Eds.) M.L. Pollock, D.H. Schmidt. Can J Appl Physiol 20:255, 256, 1995.

Shephard RJ, Rhind S, Shek PN: Exercise and training: Influences on cytotoxicity, interleukin-1, interleukin-2 and receptor structures. Int J Sports Med S154-S166, 1994.

Shephard RJ: Current status of the step test in field evaluations of aerobic fitness: The Canadian Home Fitness Test and its analogues. Sports Med Training and Rehab 5:1-13, 1995.

Shephard RJ, Rhind S, Shek PN: Exercise and the immune system: Natural killer cells, interleukins and related responses. Sports Med 18:340-369, 1994.

Shephard RJ, Rode A: Growth patterns of Canadian Inuit children: A longitudinal study. Arct Med Res 54:60-68, 1995.

Shephard RJ: Book Review: Primary Care Sports Medicine. (Eds.) D.B. McKeag, D.O. Hough. Can J Applied Physiology 19:360, 1994.

Shephard RJ: Physical activity, fitness and cardiovascular health: A brief counselling guide for older patients. Can Med Assoc J 151:557-561, 1994.

Shephard RJ: Exercise and related health-care costs: A substantial dividend of primary preventive programs? J Cardiopulmonary Rehab 14:161-165, 1994.

Shephard RJ: Cardiac rehabilitation: What are the differences in women? Perspectives in Cardiology 10:27-45, 1994.

Shephard RJ, Kavanagh T, Campbell R, Lorenz B: Net energy cost of stair climbing and ambulation in subjects with paraplegia. Sport Med Training and Rehab 5:199-210, 1994.

Shephard RJ: Physical activity and reduction of health risks: How far are the benefits independent of fat loss? J Sports Med Phys Fitness 34:91098, 1994.

Shephard RJ, Shek PN: Infectious disease in athletes: New interest for an old problem. J. Sports Med Phys Fitness 34:11-22, 1994.

Shephard RJ: Work-site exercise, physical fitness, and lost workdays. Med Exerc Nutr Health 3:268-284, 1994.

Shephard RJ, Rhind S, Shek PN: The impact of exercise on the immune system: NK cells, interleukins 1 and 2, and related responses. Ex Sport Sci Rev 23:215-241, 1995

Shephard RJ, Kavanagh T, Mertens DJ, Qureshi S: Personal health benefits of Masters athletics competition. Br J Sports Med 29, 35-40, 1995.

Shephard RJ, Royer D: Summary and conclusions. Ibid 98-100, 1995.

Shephard RJ, Shek PN: Cancer, immune function and physical activity. Can J Appl Physiol 20:1-25, 1995.

Shyu KG, Chen JJ, Shih NL, Chang H, Wang DL, Lien WP, Liew CC: Angiotensinogen gene expression is induced by cyclical mechanical stretch in cultured rat cardiomyoctyes. Biochem and Biophys Res Communications 211(I):241-248, 1995.

Shyu KG, Chen JJ, Shih NL, Chang H, Wang DL, Lien WP, Liew CC: Regulation of human cardiac myosin heavy chain genes by cyclical mechanical stretch in cultured cardiocytes. Biochem and Biophys Res Communications 210(II):567-573, 1995.

Silveira A, Karpe F, Blomback M, Steiner G, Walldius G, Hamsten A: Activation on coagulation factor VII during alimentary lipemia. Arteriosclerosis & Thrombosis 14:60-69, 1994.

Slaughter PM, Chetty R, Flintoft VF, Lewis S, Sykora K, Beattie DM, Schwartz L: A single centre randomized trial assessing the use of a vascular hemostasis device versus conventional manual compression following PTCA: What are the potential resource savings? Catheterization and Cardiovasc Diagnosis 34:210-214, 1995.

Sole MJ: Perspectives on future approaches to therapy in heart failure. High Blood Pressure & Cardiovasc Prevention - Heart Failure Treatment 3:211-215, 1994.

Sonnenberg H, Honrath U, Chong CK, Field LJ, Veress AT: Proximal tubular function in mice overexpressing atrial natriuretic factor. Can J Physiol Pharmacol 72:1168-1170, 1994.

Steiner G: The dyslipoproteinemias of diabetes. Atherosclerosis 110(Suppl):S27-S33, 1994.

Steiner G: Hyperinsulinemia and hypertriglyceridemia. J Inter Med 236(Supp.736):23-26, 1994.

Stephen SE, Furukawa RD, Zhang J, Li R-K, Tumiati LC, Weisel RD, Mickle DAG: Cardiac storage with University of Wisconsin solution and a nucleoside-transport blocker. Ann Thoracic Surg 59:1127-1133, 1995.

Stewart TE, Slutsky AS: Mechanical ventilation: A shifting philosphy (a review). Current Science: Current Opinion in Critical Care 1(2):49-56, 1995.

Stewart TE, Valenza F, Ribeiro SP, Wener AD, Volgyesi G, Mullen JBM, Slutsky AS: Increased nitric oxide in exhaled gas as an early marker of lung inflammation in a model of sepsis. Am J Resp Crit Care Med 151:713-718, 1995.

Strauss BH, Chisholm RJ, Keeley FW, Gotlieb AI, Logan RA, Armstrong PW: Extracellular matrix remodelling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res 75:650-658, 1994.

Thomas SG: Exercise and activity programs for older people. IN: Physiotherapy with Older Aduls. (Eds.) B. Pickles, A. Compton, J. Simpson, C. Cott, T. Vandervoort. Saunders: London, 1995.

Thomas SG: Exercise testing and prescription for sedentary adults. IN: Current Therapy in Sports Medicine 3rd Edition. (Eds.) J. Torg, R.J. Shephard. Mosby: Philadelphia pp520-526, Mosby: St. Louis, 1995.

Torrance SM, Wittnich C: Blood lactate and acid-base balance in graded neonatal hypoxia: Evidence for oxygen-restricted metabolism. J Appl Physiol 77(5):2318-2324, 1994.

Tsao PW, Mills GB, Diaz RJ, Radde IC, Parkinson D, Waddell J, Wilson GJ, Coles JG: Evidence that increases in lymphocyte tyrosine phosphorylation precede cardiac allograft rejection. Transplantation 58(4):451-457, 1994.

Tumiati LC, Mickle DAG,Weisel RD, Williams WG, Li R-K: An in vitro model to study myocardial ischemia injury. J Tiss Culture Methods 16:1-9, 1994.

Turley JE, Johnston KW: Ischemic neuropathy. IN: Vascular Surgery, 4th Edition. (Ed.) R. Rutherford, W.B. Saunders Publishers, Philadephia, pg 619-624, 1994.

Veith FJ, Abbott WM, Johnston KW, et al: Guidelines for development and use of transluminally placed endovascular prosthetic grafts in the arterial system. J Vasc Surg 21:670-685, 1995.

Veress AT, Chong CK, Honrath U, Sonnenberg H: Effect of bradykinin B2 receptor antagonist and indomethacin on natriuretic and hypotensive responses to ANF. Can J Physiol Pharmacol 72:1561-1566, 1994.

Villar J, Ribeiro SP, Mullen JBM, Kuliszewski M, Post M, Slutsky AS: Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 22(6):914-921, 1994.

Villar J, Slutsky AS: Apneic oxygenation and other nonconventional techniques of ventilatory support. IN: Principles and Practice of Mechanical Ventilation (Ed.) M.J. Tobin. McGraw-Hill, Inc., New York 23:499-509, 1994.

Villar J, Slutsky AS: Highly invasive therapies for acute lung injury. IN: Endotoxin and the Lungs, Lund Biology in Health and Disease, Volume 77 (Eds.) K.L. Brigham, C. Lenfant. Marcel Dekker, Inc., New York 17:425-455, 1994.

Vobecky SJ, Williams WG, Trusler GA, Coles JG, Rebeyka IM, Smallhorn J, Burrows P, Gow R, Freedom RM: Survival analysis of infants under age 18 months presenting with Tetralogy of Fallot. IN: Yearbook of Cardiology 1994. (Eds.) R.C. Schlant, J.J. Collins, Jr., M.A. Engle, B.J. Gersh, N.M. Kaplan, A.L. Waldo. Mosby year Book Publishers, St. Louis, MO pg280-282, 1994.

Waddell TK, Hirai T, Piovesan J, Oka T, Puskas JD, Patterson GA, Slutsky AS: The effect of heat shock on immediate post preservation lung function. Clin and Invest Med 17(5):405-413, 1994.

Walker P: Improved ICU management following rupture of abdominal aortic aneurysm. Current Therapy in Vascular Surgery, 1994.

Walker P, Romaschin A: Oxygen free radical scavengers in acute ischemia and reperfusion syndrome. Current Therapy in Vascular Surgery, 1994.

Walpola PL, Gotlieb AI, Cybulsky MI, Langille BL: VCAM-1 expression and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol 15:2-10, 1995.

Wang RX, Liew CC: The human BAT3 ortholog in rodents is predominantly and developmentally expressed in the testis. Mol and Cell Biochem 136:49-57, 1994.

Wang R, Sole MJ, Cukerman E, Liew CC: Characterization and nucleotide sequence of the cardiac α-myosin heavy chain gene from Syrian hamster. J. Mol Cell Cardiol 26:1155-1165, 1994.

Wang R, Cai X, Sole MJ, Liew CC: Characterization and structural organization of the cardiac β-myosin heavy chain gene from Syrian golden hamster. J Mol Cell Cardiol 27:1075-1087, 1995.

Weller IMR, Thomas SG, Gledhill N, Paterson D, Quinney A: A study to validate the modified Canadian Aerobic Fitness Test. Can J Appl Physiol 29(2):211-221, 1995.

Wen-Zhi R, Ng GYK, Wang RX, Wu P, O'Dowd BF, Osmond DH, George SR, Liew CC: The identification of NP25: A novel protein that is differentially expressed by neuronal subpopulations. Mol Brain Res 22:173-185, 1994.

Wong F, Liu P, Allidina Y, Blendis L: Pattern of sodium handling and its consequences in patients with preascitic cirrhosis. Gastroenterology 108:1820-1827, 1995.

Wong F, Sniderman K, Liu P, Allidina Y, Sherman M, Blendis L: Transjugular intrahepatic portosystemic stent shunt: Effects on hemodynamics and sodium homeostasis in cirrhosis and refractory ascites. Ann Int Med 122:816-822, 1995.

Wong F, Liu P, Blendis L: Assessment of central blood volume in cirrhosis by radionuclide angiography. Hepatology 20:1654-1656, 1994.

Worsley DF, Fung AY, Jue J, Burns RJ: Identification of viable myocardium with Tc-99m-MIBI infusion. J Nucl Med 36:1037-1039, 1995.

Wu X, Ackermann U, Sonnenberg H: Potassium depletion and salt-sensitive hypertension in Dahl rats: Effect on calcium, magnesium and phosphate excretions. Clin Exp Hypertension 17:989-1008, 1995.

Xie A, Wong B, Phillipson EA, Slutsky AS, Bradley TD: Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apnea. Am J Respir Crit Care Med 150:489-495, 1994.

Xie A, Bradley TD: Respiratory muscle activity during sleep. IN: The Thorax. Lung Biology in Health and Disease. (Ed.) C. Roussos, PT Macklem. New York, Marcel Dekker Vol5, 2nd Edition, Part B, Applied Physiology 137-1404, 1995.

Yang LY, Kuksis A, Myher JJ, Steiner G: Structure and origin of triglyceride moiety of plasma VLDL in the rat. J Lipid Res 36:125-136, 1995.

Yau TM, Weisel RD, Mickle DAG, Burton GW, Ingold KU, Ivanov J, Mohabeer MK, Tumiati LC, Carson SM: Vitamin E for coronary bypass surgery: A prospective, double blind, randomized trial. J Thorac Cardiovasc Surg 108:302-310, 1994.

Yeh T Jr, Rebeyka IM, Jakoi ER, Johnson DE, Dignan RJ, Dyke CM, Wechsler AS: Orotic acid improves left ventricular recovery four days after heterotopic transplantation. Ann Thorac Surg 58:409-415, 1994.

Yeo, EL, Conway EM: Disseminated intravascular coagulaton. Conn's Current Therapy, W.B. Saunders Co., 1995.

Yeo EL, Kennington J, Feurstein E: The role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model). Blood 83(9):2498-2508, 1994.

Zhu L, Wigle D, Hinek A, Kobayashi J, Ye C, Zuker M, Dodo H, Keeley FW, Rabinovitch M: The endogenous vascular elastase which governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin. J Clin Invest 94:1163-1171, 1994.

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