Research Protocol - ANZCTR



Research ProtocolStudy Title: Does the physical hospital environment have an impact on activity levels in patients recovering within an Acute Stroke and Sub-Acute Inpatient Rehabilitation Unit.Short Title: Observing activity levels within an Acute Stroke and Sub-Acute Inpatient Rehabilitation Unit pre and post transition to a new hospitalAcronym: MONACT (monitoring activity)Investigators and affiliations:Principal Investigator: Mr. Isaac TonelloPhysiotherapist, Senior Sub- Acute Inpatient RehabilitationSunshine Coast Hospital and Health Service, Queensland HealthAllied Health Department, Caloundra and Maleny Hospitals, Caloundra 4551, Maleny 4552 Mrs. Ingrid Rosbergen, Physiotherapist, Acting Clinical Leader Stroke/ GeriatricsSunshine Coast Hospital and Health Service, Queensland HealthAllied Health Department, Nambour General Hospital, Nambour, 4560 Dr. Rohan Grimley, Senior Medical Officer, Stroke consultant and GeriatricianSunshine Coast Hospital and Health Service, Queensland Health Nambour General Hospital, Nambour, 4560Associate Investigators:4. Dr. Ross Clark, NHMRC RD Wright Biomedical Fellow, University of the Sunshine Coast5. Dr. Elissa Farrow, Senior Medical Officer, Rehabilitation Consultant, Sunshine Coast Hospital and Health Service, Queensland Health, Caloundra Hospital, Caloundra, 45516. Mrs. Sally Horsley, Physiotherapist, Senior Sub-Acute Inpatient Rehabilitation, Sunshine Coast Health Service District, Queensland Health, Allied Health Department, Caloundra and Maleny Hospitals, Caloundra 4551, Maleny 4552. 7. Mrs. Katrina Walker, Clinical Leader Physiotherapist Stroke/ GeriatricsSunshine Coast Health Service District, Queensland Health, Allied Health Department, Nambour General Hospital, Nambour, 4560Other staff members: Behavioral Mapping: There will be students/ staff responsible for the behavioral mapping. Behavioral mapping will be on one weekday and one weekend day from 8:00 till 5:00 pm.Institutions and addresses where the research will take place:Acute Stroke Unit, Nambour General Hospital, Hospital Road, Nambour, 4560Rehabilitation Assessment Unit, Caloundra Hospital, West Terrace, Caloundra 4551Sunshine Coast University Hospital Acute Stroke Unit, Sunshine Coast University Hospital, Kawana Way, Kawana 4575Sunshine Coast University Hospital, Rehabilitation Unit, Sunshine Coast University Hospital, Kawana Way, Kawana 4575University of the Sunshine Coast, School of Sport and Exercise Science, 90 Sippy Downs Road, Sippy Downs 4556Abbreviations:ASUAcute Stroke UnitRAURehabilitation Assessment UnitNGHNambour General HospitalCALCaloundra Hospital SCHHSSunshine Coast Hospital and Health ServiceSCUHSunshine Coast University HospitalBMBehavioral MappingAMActivity Monitoring IntroductionPatients in acute stroke and sub-acute inpatient rehabilitation units spend most of their day inactive and alone limiting optimal recovery ADDIN EN.CITE <EndNote><Cite><Author>West</Author><Year>2012</Year><RecNum>13</RecNum><DisplayText>[1]</DisplayText><record><rec-number>13</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1422010097">13</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>West, T.</author><author>Bernhardt, J.</author></authors></contributors><auth-address>School of Health Sciences, La Trobe University, Melbourne, VIC 3086, Australia.</auth-address><titles><title>Physical activity in hospitalised stroke patients</title><secondary-title>Stroke Res Treat</secondary-title><alt-title>Stroke research and treatment</alt-title></titles><periodical><full-title>Stroke Res Treat</full-title><abbr-1>Stroke research and treatment</abbr-1></periodical><alt-periodical><full-title>Stroke Res Treat</full-title><abbr-1>Stroke research and treatment</abbr-1></alt-periodical><pages>813765</pages><volume>2012</volume><edition>2011/10/04</edition><dates><year>2012</year></dates><accession-num>21966599</accession-num><urls></urls><custom2>Pmc3182066</custom2><electronic-resource-num>10.1155/2012/813765</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[1]. A systematic review of observational studies quantifying physical activity levels in hospitalized stroke patients found that patients in acute stroke units and inpatient rehabilitation demonstrate low levels of physical activity, with the most severely affected patients spending more time of the day inactive and alone ADDIN EN.CITE <EndNote><Cite><Author>West</Author><Year>2012</Year><RecNum>13</RecNum><DisplayText>[1]</DisplayText><record><rec-number>13</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1422010097">13</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>West, T.</author><author>Bernhardt, J.</author></authors></contributors><auth-address>School of Health Sciences, La Trobe University, Melbourne, VIC 3086, Australia.</auth-address><titles><title>Physical activity in hospitalised stroke patients</title><secondary-title>Stroke Res Treat</secondary-title><alt-title>Stroke research and treatment</alt-title></titles><periodical><full-title>Stroke Res Treat</full-title><abbr-1>Stroke research and treatment</abbr-1></periodical><alt-periodical><full-title>Stroke Res Treat</full-title><abbr-1>Stroke research and treatment</abbr-1></alt-periodical><pages>813765</pages><volume>2012</volume><edition>2011/10/04</edition><dates><year>2012</year></dates><accession-num>21966599</accession-num><urls></urls><custom2>Pmc3182066</custom2><electronic-resource-num>10.1155/2012/813765</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[1]. Another study conducted in four rehabilitation centres in Europe found that patients spend more than half the day alone and inactive but that there was considerable variation in the quality and intensity of therapeutic activities received PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBXaXQ8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

ZWNOdW0+NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMl08L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJl

Yy1udW1iZXI+NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYxNzMx

NTk5Ij42PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZSBXaXQsIEwu

PC9hdXRob3I+PGF1dGhvcj5QdXRtYW4sIEsuPC9hdXRob3I+PGF1dGhvcj5EZWphZWdlciwgRS48

L2F1dGhvcj48YXV0aG9yPkJhZXJ0LCBJLjwvYXV0aG9yPjxhdXRob3I+QmVybWFuLCBQLjwvYXV0

aG9yPjxhdXRob3I+Qm9nYWVydHMsIEsuPC9hdXRob3I+PGF1dGhvcj5Ccmlua21hbm4sIE4uPC9h

dXRob3I+PGF1dGhvcj5Db25uZWxsLCBMLjwvYXV0aG9yPjxhdXRob3I+RmV5cywgSC48L2F1dGhv

cj48YXV0aG9yPkplbm5pLCBXLjwvYXV0aG9yPjxhdXRob3I+S2Fza2UsIEMuPC9hdXRob3I+PGF1

dGhvcj5MZXNhZmZyZSwgRS48L2F1dGhvcj48YXV0aG9yPkxleXMsIE0uPC9hdXRob3I+PGF1dGhv

cj5MaW5jb2xuLCBOLjwvYXV0aG9yPjxhdXRob3I+TG91Y2t4LCBGLjwvYXV0aG9yPjxhdXRob3I+

U2NodWJhY2ssIEIuPC9hdXRob3I+PGF1dGhvcj5TY2h1cHAsIFcuPC9hdXRob3I+PGF1dGhvcj5T

bWl0aCwgQi48L2F1dGhvcj48YXV0aG9yPkRlIFdlZXJkdCwgVy48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJlaGFiaWxpdGF0aW9u

IFNjaWVuY2VzLCBGYWN1bHR5IG9mIEtpbmVzaW9sb2d5IGFuZCBSZWhhYmlsaXRhdGlvbiBTY2ll

bmNlcywgS2F0aG9saWVrZSBVbml2ZXJzaXRlaXQgTGV1dmVuLCBCZWxnaXVtLiBMaWVzYmV0LkRl

d2l0QGZhYmVyLmt1bGV1dmVuLmJlPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VXNlIG9m

IHRpbWUgYnkgc3Ryb2tlIHBhdGllbnRzOiBhIGNvbXBhcmlzb24gb2YgZm91ciBFdXJvcGVhbiBy

ZWhhYmlsaXRhdGlvbiBjZW50ZXJzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlN0cm9rZTwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+U3Ryb2tlOyBhIGpvdXJuYWwgb2YgY2VyZWJyYWwgY2ly

Y3VsYXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJv

a2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJj

dWxhdGlvbjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

U3Ryb2tlPC9mdWxsLXRpdGxlPjxhYmJyLTE+U3Ryb2tlOyBhIGpvdXJuYWwgb2YgY2VyZWJyYWwg

Y2lyY3VsYXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xOTc3LTgzPC9wYWdl

cz48dm9sdW1lPjM2PC92b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGVkaXRpb24+MjAwNS8wOC8w

NjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8

L2tleXdvcmQ+PGtleXdvcmQ+QmVoYXZpb3I8L2tleXdvcmQ+PGtleXdvcmQ+QmVsZ2l1bTwva2V5

d29yZD48a2V5d29yZD5DZXJlYnJvdmFzY3VsYXIgRGlzb3JkZXJzL3RoZXJhcHk8L2tleXdvcmQ+

PGtleXdvcmQ+RGlzYWJpbGl0eSBFdmFsdWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkV1cm9wZTwv

a2V5d29yZD48a2V5d29yZD5HZXJtYW55PC9rZXl3b3JkPjxrZXl3b3JkPkdyZWF0IEJyaXRhaW48

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxlbmd0aCBvZiBTdGF5

PC9rZXl3b3JkPjxrZXl3b3JkPk1vZGVscywgU3RhdGlzdGljYWw8L2tleXdvcmQ+PGtleXdvcmQ+

T3V0Y29tZSBBc3Nlc3NtZW50IChIZWFsdGggQ2FyZSk8L2tleXdvcmQ+PGtleXdvcmQ+UmVoYWJp

bGl0YXRpb24vbWFucG93ZXIvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+KlJlaGFiaWxpdGF0

aW9uIENlbnRlcnM8L2tleXdvcmQ+PGtleXdvcmQ+U3Ryb2tlLypyZWhhYmlsaXRhdGlvbi8qdGhl

cmFweTwva2V5d29yZD48a2V5d29yZD5Td2l0emVybGFuZDwva2V5d29yZD48a2V5d29yZD5UaW1l

PC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0y

NDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDgxODYwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE2MS8wMS5TVFIuMDAwMDE3Nzg3MS41

OTAwMy5lMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRl

cj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48

L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EZSBXaXQ8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS

ZWNOdW0+NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMl08L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJl

Yy1udW1iZXI+NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9

ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYxNzMx

NTk5Ij42PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs

ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EZSBXaXQsIEwu

PC9hdXRob3I+PGF1dGhvcj5QdXRtYW4sIEsuPC9hdXRob3I+PGF1dGhvcj5EZWphZWdlciwgRS48

L2F1dGhvcj48YXV0aG9yPkJhZXJ0LCBJLjwvYXV0aG9yPjxhdXRob3I+QmVybWFuLCBQLjwvYXV0

aG9yPjxhdXRob3I+Qm9nYWVydHMsIEsuPC9hdXRob3I+PGF1dGhvcj5Ccmlua21hbm4sIE4uPC9h

dXRob3I+PGF1dGhvcj5Db25uZWxsLCBMLjwvYXV0aG9yPjxhdXRob3I+RmV5cywgSC48L2F1dGhv

cj48YXV0aG9yPkplbm5pLCBXLjwvYXV0aG9yPjxhdXRob3I+S2Fza2UsIEMuPC9hdXRob3I+PGF1

dGhvcj5MZXNhZmZyZSwgRS48L2F1dGhvcj48YXV0aG9yPkxleXMsIE0uPC9hdXRob3I+PGF1dGhv

cj5MaW5jb2xuLCBOLjwvYXV0aG9yPjxhdXRob3I+TG91Y2t4LCBGLjwvYXV0aG9yPjxhdXRob3I+

U2NodWJhY2ssIEIuPC9hdXRob3I+PGF1dGhvcj5TY2h1cHAsIFcuPC9hdXRob3I+PGF1dGhvcj5T

bWl0aCwgQi48L2F1dGhvcj48YXV0aG9yPkRlIFdlZXJkdCwgVy48L2F1dGhvcj48L2F1dGhvcnM+

PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJlaGFiaWxpdGF0aW9u

IFNjaWVuY2VzLCBGYWN1bHR5IG9mIEtpbmVzaW9sb2d5IGFuZCBSZWhhYmlsaXRhdGlvbiBTY2ll

bmNlcywgS2F0aG9saWVrZSBVbml2ZXJzaXRlaXQgTGV1dmVuLCBCZWxnaXVtLiBMaWVzYmV0LkRl

d2l0QGZhYmVyLmt1bGV1dmVuLmJlPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VXNlIG9m

IHRpbWUgYnkgc3Ryb2tlIHBhdGllbnRzOiBhIGNvbXBhcmlzb24gb2YgZm91ciBFdXJvcGVhbiBy

ZWhhYmlsaXRhdGlvbiBjZW50ZXJzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlN0cm9rZTwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+U3Ryb2tlOyBhIGpvdXJuYWwgb2YgY2VyZWJyYWwgY2ly

Y3VsYXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJv

a2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJj

dWxhdGlvbjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

U3Ryb2tlPC9mdWxsLXRpdGxlPjxhYmJyLTE+U3Ryb2tlOyBhIGpvdXJuYWwgb2YgY2VyZWJyYWwg

Y2lyY3VsYXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xOTc3LTgzPC9wYWdl

cz48dm9sdW1lPjM2PC92b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGVkaXRpb24+MjAwNS8wOC8w

NjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8

L2tleXdvcmQ+PGtleXdvcmQ+QmVoYXZpb3I8L2tleXdvcmQ+PGtleXdvcmQ+QmVsZ2l1bTwva2V5

d29yZD48a2V5d29yZD5DZXJlYnJvdmFzY3VsYXIgRGlzb3JkZXJzL3RoZXJhcHk8L2tleXdvcmQ+

PGtleXdvcmQ+RGlzYWJpbGl0eSBFdmFsdWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkV1cm9wZTwv

a2V5d29yZD48a2V5d29yZD5HZXJtYW55PC9rZXl3b3JkPjxrZXl3b3JkPkdyZWF0IEJyaXRhaW48

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxlbmd0aCBvZiBTdGF5

PC9rZXl3b3JkPjxrZXl3b3JkPk1vZGVscywgU3RhdGlzdGljYWw8L2tleXdvcmQ+PGtleXdvcmQ+

T3V0Y29tZSBBc3Nlc3NtZW50IChIZWFsdGggQ2FyZSk8L2tleXdvcmQ+PGtleXdvcmQ+UmVoYWJp

bGl0YXRpb24vbWFucG93ZXIvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+KlJlaGFiaWxpdGF0

aW9uIENlbnRlcnM8L2tleXdvcmQ+PGtleXdvcmQ+U3Ryb2tlLypyZWhhYmlsaXRhdGlvbi8qdGhl

cmFweTwva2V5d29yZD48a2V5d29yZD5Td2l0emVybGFuZDwva2V5d29yZD48a2V5d29yZD5UaW1l

PC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA1PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0y

NDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE2MDgxODYwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE2MS8wMS5TVFIuMDAwMDE3Nzg3MS41

OTAwMy5lMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRl

cj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48

L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE.DATA [2]. Unfortunately, observational data from Australian studies are showing similar activity levels with 61% of a working day spent in bed and only 13% participating in transfer and gait activities PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJuaGFyZHQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

PjxSZWNOdW0+NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bM108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYx

NzMxNjI4Ij43PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CZXJuaGFy

ZHQsIEouPC9hdXRob3I+PGF1dGhvcj5DaGl0cmF2YXMsIE4uPC9hdXRob3I+PGF1dGhvcj5NZXNs

bywgSS4gTC48L2F1dGhvcj48YXV0aG9yPlRocmlmdCwgQS4gRy48L2F1dGhvcj48YXV0aG9yPklu

ZHJlZGF2aWssIEIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+TmF0aW9uYWwgU3Ryb2tlIFJlc2VhcmNoIEluc3RpdHV0ZSwgTGV2ZWwgMSwgTmV1cm9zY2ll

bmNlcyBCdWlsZGluZywgSGVpZGVsYmVyZyBSZXBhdHJpYXRpb24gSG9zcGl0YWwsIDMwMCBXYXRl

cmRhbGUgUm9hZCwgSGVpZGVsYmVyZywgMzA4MSBWaWN0b3JpYSwgQXVzdHJhbGlhLiBKLkJlcm5o

YXJkdEB1bmltZWxiLmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vdCBhbGwg

c3Ryb2tlIHVuaXRzIGFyZSB0aGUgc2FtZTogYSBjb21wYXJpc29uIG9mIHBoeXNpY2FsIGFjdGl2

aXR5IHBhdHRlcm5zIGluIE1lbGJvdXJuZSwgQXVzdHJhbGlhLCBhbmQgVHJvbmRoZWltLCBOb3J3

YXk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVsbC10aXRsZT48YWJi

ci0xPlN0cm9rZTsgYSBqb3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9uPC9hYmJyLTE+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+

PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwNTktNjU8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVt

ZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDA4LzA1LzAzPC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkF1c3RyYWxpYTwva2V5d29yZD48

a2V5d29yZD4qRWFybHkgQW1idWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+Kk1vdG9yIEFjdGl2aXR5PC9rZXl3b3JkPjxrZXl3b3JkPk5vcndheTwva2V5d29y

ZD48a2V5d29yZD5PY2N1cGF0aW9uYWwgVGhlcmFweSBEZXBhcnRtZW50LCBIb3NwaXRhbDwva2V5

d29yZD48a2V5d29yZD5PdXRjb21lIEFzc2Vzc21lbnQgKEhlYWx0aCBDYXJlKTwva2V5d29yZD48

a2V5d29yZD5QaHlzaWNhbCBUaGVyYXB5IERlcGFydG1lbnQsIEhvc3BpdGFsPC9rZXl3b3JkPjxr

ZXl3b3JkPlN0cm9rZS8qcmVoYWJpbGl0YXRpb24vdGhlcmFweTwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4NDUx

MzUxPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTE2MS9zdHJva2VhaGEuMTA3LjUwNzE2MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJuaGFyZHQ8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

PjxSZWNOdW0+NzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bM108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYx

NzMxNjI4Ij43PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CZXJuaGFy

ZHQsIEouPC9hdXRob3I+PGF1dGhvcj5DaGl0cmF2YXMsIE4uPC9hdXRob3I+PGF1dGhvcj5NZXNs

bywgSS4gTC48L2F1dGhvcj48YXV0aG9yPlRocmlmdCwgQS4gRy48L2F1dGhvcj48YXV0aG9yPklu

ZHJlZGF2aWssIEIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl

c3M+TmF0aW9uYWwgU3Ryb2tlIFJlc2VhcmNoIEluc3RpdHV0ZSwgTGV2ZWwgMSwgTmV1cm9zY2ll

bmNlcyBCdWlsZGluZywgSGVpZGVsYmVyZyBSZXBhdHJpYXRpb24gSG9zcGl0YWwsIDMwMCBXYXRl

cmRhbGUgUm9hZCwgSGVpZGVsYmVyZywgMzA4MSBWaWN0b3JpYSwgQXVzdHJhbGlhLiBKLkJlcm5o

YXJkdEB1bmltZWxiLmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vdCBhbGwg

c3Ryb2tlIHVuaXRzIGFyZSB0aGUgc2FtZTogYSBjb21wYXJpc29uIG9mIHBoeXNpY2FsIGFjdGl2

aXR5IHBhdHRlcm5zIGluIE1lbGJvdXJuZSwgQXVzdHJhbGlhLCBhbmQgVHJvbmRoZWltLCBOb3J3

YXk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10

aXRsZT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVsbC10aXRsZT48YWJi

ci0xPlN0cm9rZTsgYSBqb3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9uPC9hYmJyLTE+PC9w

ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+

PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIwNTktNjU8L3BhZ2VzPjx2b2x1bWU+Mzk8L3ZvbHVt

ZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDA4LzA1LzAzPC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

PkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkF1c3RyYWxpYTwva2V5d29yZD48

a2V5d29yZD4qRWFybHkgQW1idWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3

b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+

PGtleXdvcmQ+Kk1vdG9yIEFjdGl2aXR5PC9rZXl3b3JkPjxrZXl3b3JkPk5vcndheTwva2V5d29y

ZD48a2V5d29yZD5PY2N1cGF0aW9uYWwgVGhlcmFweSBEZXBhcnRtZW50LCBIb3NwaXRhbDwva2V5

d29yZD48a2V5d29yZD5PdXRjb21lIEFzc2Vzc21lbnQgKEhlYWx0aCBDYXJlKTwva2V5d29yZD48

a2V5d29yZD5QaHlzaWNhbCBUaGVyYXB5IERlcGFydG1lbnQsIEhvc3BpdGFsPC9rZXl3b3JkPjxr

ZXl3b3JkPlN0cm9rZS8qcmVoYWJpbGl0YXRpb24vdGhlcmFweTwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4NDUx

MzUxPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTE2MS9zdHJva2VhaGEuMTA3LjUwNzE2MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE.DATA [3]. There is very little evidence available on how much social and cognitive activity is occurring in acute stroke and sub-acute inpatient rehabilitation centres. In one rehabilitation centre, patients were observed spending around 30% in social activities and 5% on cognitive activities ADDIN EN.CITE <EndNote><Cite><Author>Janssen</Author><Year>2014</Year><RecNum>16</RecNum><DisplayText>[4]</DisplayText><record><rec-number>16</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1422013069">16</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Janssen, H.</author><author>Ada, L.</author><author>Bernhardt, J.</author><author>McElduff, P.</author><author>Pollack, M.</author><author>Nilsson, M.</author><author>Spratt, N. J.</author></authors></contributors><auth-address>University of Newcastle .</auth-address><titles><title>An enriched environment increases activity in stroke patients undergoing rehabilitation in a mixed rehabilitation unit: a pilot non-randomized controlled trial</title><secondary-title>Disabil Rehabil</secondary-title><alt-title>Disability and rehabilitation</alt-title></titles><periodical><full-title>Disabil Rehabil</full-title><abbr-1>Disability and rehabilitation</abbr-1></periodical><alt-periodical><full-title>Disabil Rehabil</full-title><abbr-1>Disability and rehabilitation</abbr-1></alt-periodical><pages>255-62</pages><volume>36</volume><number>3</number><edition>2013/05/01</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Leisure Activities</keyword><keyword>Male</keyword><keyword>*Motor Activity</keyword><keyword>Pilot Projects</keyword><keyword>Prospective Studies</keyword><keyword>Stroke/*rehabilitation</keyword></keywords><dates><year>2014</year></dates><isbn>0963-8288</isbn><accession-num>23627534</accession-num><urls></urls><electronic-resource-num>10.3109/09638288.2013.788218</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[4]. Taken together, evidence in acute stroke and sub-acute inpatient rehabilitation centres are indicating that participation levels in all activity domains are low.Australian and United Kingdom Stroke Guidelines recommend that rehabilitation should be structured to provide as much practice performing activities of daily living as possible within the first six months after stroke PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XcmlnaHQ8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+Mzk8L1JlY051bT48RGlzcGxheVRleHQ+WzUsIDZdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjM5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9IjE0

NjE3NDExMTAiPjM5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Xcmln

aHQsIEwuPC9hdXRob3I+PGF1dGhvcj5IaWxsLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+QmVybmhh

cmR0LCBKLjwvYXV0aG9yPjxhdXRob3I+TGluZGxleSwgUi48L2F1dGhvcj48YXV0aG9yPkFkYSwg

TC48L2F1dGhvcj48YXV0aG9yPkJham9yZWssIEIuIFYuPC9hdXRob3I+PGF1dGhvcj5CYXJiZXIs

IFAuIEEuPC9hdXRob3I+PGF1dGhvcj5CZWVyLCBDLjwvYXV0aG9yPjxhdXRob3I+R29sbGVkZ2Us

IEouPC9hdXRob3I+PGF1dGhvcj5HdXN0YWZzc29uLCBMLjwvYXV0aG9yPjxhdXRob3I+SGVyc2gs

IEQuPC9hdXRob3I+PGF1dGhvcj5LZW5hcmR5LCBKLjwvYXV0aG9yPjxhdXRob3I+UGVycnksIEwu

PC9hdXRob3I+PGF1dGhvcj5NaWRkbGV0b24sIFMuPC9hdXRob3I+PGF1dGhvcj5CcmF1ZXIsIFMu

IEcuPC9hdXRob3I+PGF1dGhvcj5OZWxzb24sIE0uIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+R3VpZGVsaW5lcyBQcm9ncmFtLCBOYXRpb25hbCBTdHJv

a2UgRm91bmRhdGlvbiwgRmxvcmV5IE5ldXJvc2NpZW5jZSBJbnN0aXR1dGVzLCBNZWxib3VybmUs

IFZpY3RvcmlhLCBBdXN0cmFsaWEuIGx3cmlnaHRAc3Ryb2tlZm91bmRhdGlvbi5jb20uYXU8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TdHJva2UgbWFuYWdlbWVudDogdXBkYXRlZCByZWNv

bW1lbmRhdGlvbnMgZm9yIHRyZWF0bWVudCBhbG9uZyB0aGUgY2FyZSBjb250aW51dW08L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+SW50ZXJuIE1lZCBKPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5JbnRlcm5hbCBtZWRpY2luZSBqb3VybmFsPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+SW50ZXJuIE1lZCBKPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50ZXJuYWwg

bWVkaWNpbmUgam91cm5hbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+SW50ZXJuIE1lZCBKPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50ZXJuYWwgbWVkaWNp

bmUgam91cm5hbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjU2Mi05PC9wYWdlcz48

dm9sdW1lPjQyPC92b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGVkaXRpb24+MjAxMi8wNS8yNDwv

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+Q29udGludWl0eSBvZiBQYXRpZW50IENhcmUvKnN0

YW5kYXJkcy90cmVuZHM8L2tleXdvcmQ+PGtleXdvcmQ+RGlzZWFzZSBNYW5hZ2VtZW50PC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5QcmFjdGljZSBHdWlkZWxpbmVz

IGFzIFRvcGljLypzdGFuZGFyZHM8L2tleXdvcmQ+PGtleXdvcmQ+U3Ryb2tlL2RpYWdub3Npcy9l

cGlkZW1pb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8

L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxk

YXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NDQtMDkwMzwvaXNibj48

YWNjZXNzaW9uLW51bT4yMjYxNjk2MDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNDQ1LTU5OTQuMjAxMi4wMjc3NC54PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPk5JQ0U8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NDA8

L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2

IiB0aW1lc3RhbXA9IjE0NjE3NDI4NTIiPjQwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IldlYiBQYWdlIj4xMjwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPk5JQ0U8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

U3Ryb2tlIFJlaGFiaWxpdGF0aW9uOiB0aGVyYXB5PC90aXRsZT48L3RpdGxlcz48dm9sdW1lPjIw

MTY8L3ZvbHVtZT48bnVtYmVyPjEgZmViPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+

PC9kYXRlcz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3BhdGh3YXlzLm5pY2Uub3Jn

LnVrL3BhdGh3YXlzL3N0cm9rZSNwYXRoPXZpZXclM0EvcGF0aHdheXMvc3Ryb2tlL3N0cm9rZS1y

ZWhhYmlsaXRhdGlvbi10aGVyYXB5LnhtbCZhbXA7Y29udGVudD12aWV3LXF1YWxpdHktc3RhdGVt

ZW50JTNBcXVhbGl0eS1zdGF0ZW1lbnRzLWludGVuc2l0eS1vZi1zdHJva2UtcmVoYWJpbGl0YXRp

b248L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

AAA=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XcmlnaHQ8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS

ZWNOdW0+Mzk8L1JlY051bT48RGlzcGxheVRleHQ+WzUsIDZdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjM5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9IjE0

NjE3NDExMTAiPjM5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Xcmln

aHQsIEwuPC9hdXRob3I+PGF1dGhvcj5IaWxsLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+QmVybmhh

cmR0LCBKLjwvYXV0aG9yPjxhdXRob3I+TGluZGxleSwgUi48L2F1dGhvcj48YXV0aG9yPkFkYSwg

TC48L2F1dGhvcj48YXV0aG9yPkJham9yZWssIEIuIFYuPC9hdXRob3I+PGF1dGhvcj5CYXJiZXIs

IFAuIEEuPC9hdXRob3I+PGF1dGhvcj5CZWVyLCBDLjwvYXV0aG9yPjxhdXRob3I+R29sbGVkZ2Us

IEouPC9hdXRob3I+PGF1dGhvcj5HdXN0YWZzc29uLCBMLjwvYXV0aG9yPjxhdXRob3I+SGVyc2gs

IEQuPC9hdXRob3I+PGF1dGhvcj5LZW5hcmR5LCBKLjwvYXV0aG9yPjxhdXRob3I+UGVycnksIEwu

PC9hdXRob3I+PGF1dGhvcj5NaWRkbGV0b24sIFMuPC9hdXRob3I+PGF1dGhvcj5CcmF1ZXIsIFMu

IEcuPC9hdXRob3I+PGF1dGhvcj5OZWxzb24sIE0uIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+R3VpZGVsaW5lcyBQcm9ncmFtLCBOYXRpb25hbCBTdHJv

a2UgRm91bmRhdGlvbiwgRmxvcmV5IE5ldXJvc2NpZW5jZSBJbnN0aXR1dGVzLCBNZWxib3VybmUs

IFZpY3RvcmlhLCBBdXN0cmFsaWEuIGx3cmlnaHRAc3Ryb2tlZm91bmRhdGlvbi5jb20uYXU8L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TdHJva2UgbWFuYWdlbWVudDogdXBkYXRlZCByZWNv

bW1lbmRhdGlvbnMgZm9yIHRyZWF0bWVudCBhbG9uZyB0aGUgY2FyZSBjb250aW51dW08L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+SW50ZXJuIE1lZCBKPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs

ZT5JbnRlcm5hbCBtZWRpY2luZSBqb3VybmFsPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+SW50ZXJuIE1lZCBKPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50ZXJuYWwg

bWVkaWNpbmUgam91cm5hbDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+SW50ZXJuIE1lZCBKPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50ZXJuYWwgbWVkaWNp

bmUgam91cm5hbDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjU2Mi05PC9wYWdlcz48

dm9sdW1lPjQyPC92b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGVkaXRpb24+MjAxMi8wNS8yNDwv

ZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+Q29udGludWl0eSBvZiBQYXRpZW50IENhcmUvKnN0

YW5kYXJkcy90cmVuZHM8L2tleXdvcmQ+PGtleXdvcmQ+RGlzZWFzZSBNYW5hZ2VtZW50PC9rZXl3

b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5QcmFjdGljZSBHdWlkZWxpbmVz

IGFzIFRvcGljLypzdGFuZGFyZHM8L2tleXdvcmQ+PGtleXdvcmQ+U3Ryb2tlL2RpYWdub3Npcy9l

cGlkZW1pb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8

L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxk

YXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NDQtMDkwMzwvaXNibj48

YWNjZXNzaW9uLW51bT4yMjYxNjk2MDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNDQ1LTU5OTQuMjAxMi4wMjc3NC54PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPk5JQ0U8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NDA8

L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+

PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2

IiB0aW1lc3RhbXA9IjE0NjE3NDI4NTIiPjQwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IldlYiBQYWdlIj4xMjwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPk5JQ0U8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+

U3Ryb2tlIFJlaGFiaWxpdGF0aW9uOiB0aGVyYXB5PC90aXRsZT48L3RpdGxlcz48dm9sdW1lPjIw

MTY8L3ZvbHVtZT48bnVtYmVyPjEgZmViPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+

PC9kYXRlcz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3BhdGh3YXlzLm5pY2Uub3Jn

LnVrL3BhdGh3YXlzL3N0cm9rZSNwYXRoPXZpZXclM0EvcGF0aHdheXMvc3Ryb2tlL3N0cm9rZS1y

ZWhhYmlsaXRhdGlvbi10aGVyYXB5LnhtbCZhbXA7Y29udGVudD12aWV3LXF1YWxpdHktc3RhdGVt

ZW50JTNBcXVhbGl0eS1zdGF0ZW1lbnRzLWludGVuc2l0eS1vZi1zdHJva2UtcmVoYWJpbGl0YXRp

b248L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

AAA=

ADDIN EN.CITE.DATA [5, 6]. This can be achieved by mobilising early and frequently, and engaging stroke survivors in functional upper limb activity to prevent secondary complications like learned non-use ADDIN EN.CITE <EndNote><Cite><Author>Taub</Author><Year>2006</Year><RecNum>36</RecNum><DisplayText>[7]</DisplayText><record><rec-number>36</rec-number><foreign-keys><key app="EN" db-id="ezw0r5rx7p0sztextfzvzvrvtxdrzewx005v" timestamp="1461736541">36</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Taub, E.</author><author>Uswatte, G.</author><author>Mark, V. W.</author><author>Morris, D. M.</author></authors></contributors><auth-address>Department of Psychology, School of Social and Behavioral Sciences, University of Alabama at Birmingham, 1530 3rd Avenue S., Birmingham, AL 35294, USA. etaub@uab.edu</auth-address><titles><title>The learned nonuse phenomenon: implications for rehabilitation</title><secondary-title>Eura Medicophys</secondary-title><alt-title>Europa medicophysica</alt-title></titles><periodical><full-title>Eura Medicophys</full-title><abbr-1>Europa medicophysica</abbr-1></periodical><alt-periodical><full-title>Eura Medicophys</full-title><abbr-1>Europa medicophysica</abbr-1></alt-periodical><pages>241-56</pages><volume>42</volume><number>3</number><edition>2006/10/14</edition><keywords><keyword>Animals</keyword><keyword>Conditioning, Operant</keyword><keyword>Helplessness, Learned</keyword><keyword>Humans</keyword><keyword>Movement Disorders/*rehabilitation</keyword><keyword>*Physical Therapy Modalities</keyword><keyword>Physical and Rehabilitation Medicine/*methods</keyword><keyword>*Restraint, Physical</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0014-2573 (Print)&#xD;0014-2573</isbn><accession-num>17039223</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[7]. There is strong evidence supporting intense meaningful practice of functional upper limb activity and gait re-training to achieve optimal functional recovery, but intense therapy is therapist driven and costly PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVwaGVyZDwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+

PFJlY051bT4yPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4LTExXTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4yPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9IjE0

NjE3MzEzMzUiPjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNoZXBo

ZXJkLCBSLiBCLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

PlNjaG9vbCBvZiBQaHlzaW90aGVyYXB5LCBGYWN1bHR5IG9mIEhlYWx0aCBTY2llbmNlcywgVGhl

IFVuaXZlcnNpdHkgb2YgU3lkbmV5LCBBdXN0cmFsaWEuIFIuU2hlcGhlcmRAY2Nocy51c3lkLmVk

dS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkV4ZXJjaXNlIGFuZCB0cmFpbmluZyB0

byBvcHRpbWl6ZSBmdW5jdGlvbmFsIG1vdG9yIHBlcmZvcm1hbmNlIGluIHN0cm9rZTogZHJpdmlu

ZyBuZXVyYWwgcmVvcmdhbml6YXRpb24/PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJhbCBQ

bGFzdDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TmV1cmFsIHBsYXN0aWNpdHk8L2FsdC10

aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXVyYWwgUGxhc3Q8L2Z1bGwt

dGl0bGU+PGFiYnItMT5OZXVyYWwgcGxhc3RpY2l0eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cmFsIFBsYXN0PC9mdWxsLXRpdGxlPjxhYmJyLTE+

TmV1cmFsIHBsYXN0aWNpdHk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMjEtOTwv

cGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PG51bWJlcj4xLTI8L251bWJlcj48ZWRpdGlvbj4yMDAx

LzA5LzA0PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qRXhlcmNpc2UgVGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TmV1cm9uYWwgUGxhc3RpY2l0

eS8qcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlvbi9waHlz

aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS8qcGh5c2lvcGF0aG9sb2d5Lyp0aGVyYXB5

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PC9kYXRlcz48aXNi

bj4yMDkwLTU5MDQgKFByaW50KSYjeEQ7MTY4Ny01NDQzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEx

NTMwODgzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QbWMyNTY1Mzg2PC9j

dXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTU1L25wLjIwMDEuMTIxPC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPlRlYXNlbGw8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNOdW0+

MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1

diIgdGltZXN0YW1wPSIxNDYxNzMxNDMwIj4zPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5UZWFzZWxsLCBSLjwvYXV0aG9yPjxhdXRob3I+Rm9sZXksIE4uPC9hdXRob3I+

PGF1dGhvcj5TYWx0ZXIsIEsuPC9hdXRob3I+PGF1dGhvcj5CaG9nYWwsIFMuPC9hdXRob3I+PGF1

dGhvcj5KdXRhaSwgSi48L2F1dGhvcj48YXV0aG9yPlNwZWVjaGxleSwgTS48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBoeXNpY2Fs

IE1lZGljaW5lIGFuZCBSZWhhYmlsaXRhdGlvbiwgU3QuIEpvc2VwaCZhcG9zO3MgSGVhbHRoIENh

cmUgTG9uZG9uLCBQYXJrd29vZCBIb3NwaXRhbCwgT250YXJpbywgQ2FuYWRhLjwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPkV2aWRlbmNlLUJhc2VkIFJldmlldyBvZiBTdHJva2UgUmVoYWJp

bGl0YXRpb246IGV4ZWN1dGl2ZSBzdW1tYXJ5LCAxMnRoIGVkaXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+VG9wIFN0cm9rZSBSZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5U

b3BpY3MgaW4gc3Ryb2tlIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+VG9wIFN0cm9rZSBSZWhhYmlsPC9mdWxsLXRpdGxlPjxhYmJyLTE+

VG9waWNzIGluIHN0cm9rZSByZWhhYmlsaXRhdGlvbjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+VG9wIFN0cm9rZSBSZWhhYmlsPC9mdWxsLXRpdGxlPjxh

YmJyLTE+VG9waWNzIGluIHN0cm9rZSByZWhhYmlsaXRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjQ2My04ODwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+Njwv

bnVtYmVyPjxlZGl0aW9uPjIwMTAvMDIvMDk8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkRh

dGFiYXNlcywgRmFjdHVhbC9zdGF0aXN0aWNzICZhbXA7IG51bWVyaWNhbCBkYXRhPC9rZXl3b3Jk

PjxrZXl3b3JkPipFdmlkZW5jZS1CYXNlZCBNZWRpY2luZTwva2V5d29yZD48a2V5d29yZD5IdW1h

bnM8L2tleXdvcmQ+PGtleXdvcmQ+TWV0YS1BbmFseXNpcyBhcyBUb3BpYzwva2V5d29yZD48a2V5

d29yZD5OZWVkcyBBc3Nlc3NtZW50L3N0YXRpc3RpY3MgJmFtcDsgbnVtZXJpY2FsIGRhdGE8L2tl

eXdvcmQ+PGtleXdvcmQ+KlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllczwva2V5d29yZD48a2V5

d29yZD5SZWhhYmlsaXRhdGlvbiBDZW50ZXJzPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS8qcmVo

YWJpbGl0YXRpb248L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk5vdi1EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4x

MDc0LTkzNTcgKFByaW50KSYjeEQ7MTA3NC05MzU3PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMTM5

MDQ5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTMxMC90c3IxNjA2LTQ2MzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRh

YmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5n

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5GcmVuY2g8L0F1dGhvcj48

WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+NDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDwv

cmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Aw

c3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYxNzMxNTIyIj40PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5GcmVuY2gsIEIuPC9hdXRob3I+PGF1

dGhvcj5UaG9tYXMsIEwuIEguPC9hdXRob3I+PGF1dGhvcj5MZWF0aGxleSwgTS4gSi48L2F1dGhv

cj48YXV0aG9yPlN1dHRvbiwgQy4gSi48L2F1dGhvcj48YXV0aG9yPk1jQWRhbSwgSi48L2F1dGhv

cj48YXV0aG9yPkZvcnN0ZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5MYW5naG9ybmUsIFAuPC9hdXRo

b3I+PGF1dGhvcj5QcmljZSwgQy4gSS48L2F1dGhvcj48YXV0aG9yPldhbGtlciwgQS48L2F1dGhv

cj48YXV0aG9yPldhdGtpbnMsIEMuIEwuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBDZW50cmFsIExhbmNhc2hpcmUsIERlcGFydG1l

bnQgb2YgTnVyc2luZywgUHJlc3RvbiwgVUssIFBSMSAySEUuIGJmcmVuY2gxQHVjbGFuLmFjLnVr

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVwZXRpdGl2ZSB0YXNrIHRyYWluaW5nIGZv

ciBpbXByb3ZpbmcgZnVuY3Rpb25hbCBhYmlsaXR5IGFmdGVyIHN0cm9rZTwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Db2NocmFuZSBEYXRhYmFzZSBTeXN0IFJldjwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+VGhlIENvY2hyYW5lIGRhdGFiYXNlIG9mIHN5c3RlbWF0aWMgcmV2aWV3czwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNvY2hyYW5lIERhdGFiYXNl

IFN5c3QgUmV2PC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhlIENvY2hyYW5lIGRhdGFiYXNlIG9mIHN5

c3RlbWF0aWMgcmV2aWV3czwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Q29jaHJhbmUgRGF0YWJhc2UgU3lzdCBSZXY8L2Z1bGwtdGl0bGU+PGFiYnItMT5U

aGUgQ29jaHJhbmUgZGF0YWJhc2Ugb2Ygc3lzdGVtYXRpYyByZXZpZXdzPC9hYmJyLTE+PC9hbHQt

cGVyaW9kaWNhbD48cGFnZXM+Q2QwMDYwNzM8L3BhZ2VzPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0

aW9uPjIwMDcvMTAvMTk8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPipBY3Rpdml0aWVzIG9m

IERhaWx5IExpdmluZzwva2V5d29yZD48a2V5d29yZD5FeHRyZW1pdGllczwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TW90b3IgQWN0aXZpdHk8L2tleXdvcmQ+PGtl

eXdvcmQ+KlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllczwva2V5d29yZD48a2V5d29yZD5SYW5k

b21pemVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPipSZWNv

dmVyeSBvZiBGdW5jdGlvbjwva2V5d29yZD48a2V5d29yZD5TdHJva2UvKnJlaGFiaWxpdGF0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPlRhc2sgUGVyZm9ybWFuY2UgYW5kIEFuYWx5c2lzPC9rZXl3b3Jk

PjxrZXl3b3JkPldhbGtpbmc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwv

eWVhcj48L2RhdGVzPjxpc2JuPjEzNjEtNjEzNzwvaXNibj48YWNjZXNzaW9uLW51bT4xNzk0Mzg4

MzwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwMDIvMTQ2NTE4NTguQ0QwMDYwNzMucHViMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5WZWVyYmVl

azwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xMDwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk

PSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQyMjAw

NzIyOSI+MTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlZlZXJiZWVr

LCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+dmFuIFdlZ2VuLCBFLjwvYXV0aG9yPjxhdXRob3I+dmFu

IFBlcHBlbiwgUi48L2F1dGhvcj48YXV0aG9yPnZhbiBkZXIgV2VlcywgUC4gSi48L2F1dGhvcj48

YXV0aG9yPkhlbmRyaWtzLCBFLjwvYXV0aG9yPjxhdXRob3I+UmlldGJlcmcsIE0uPC9hdXRob3I+

PGF1dGhvcj5Ld2Fra2VsLCBHLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUmVoYWJpbGl0YXRpb24gTWVkaWNpbmUsIE1PVkUgUmVz

ZWFyY2ggSW5zdGl0dXRlIEFtc3RlcmRhbSwgVlUgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwg

QW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9mIFBoeXNpb3RoZXJh

cHksIFVuaXZlcnNpdHkgb2YgQXBwbGllZCBTY2llbmNlcyBVdHJlY2h0LCBVdHJlY2h0LCBUaGUg

TmV0aGVybGFuZHMuJiN4RDtTY2llbnRpZmljIEluc3RpdHV0ZSBmb3IgUXVhbGl0eSBvZiBIZWFs

dGhjYXJlIChJUSBoZWFsdGhjYXJlKSwgUmFkYm91ZCBVbml2ZXJzaXR5IE5pam1lZ2VuIE1lZGlj

YWwgQ2VudGVyLCBOaWptZWdlbiwgVGhlIE5ldGhlcmxhbmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBF

cGlkZW1pb2xvZ3ksIE1hYXN0cmljaHQgVW5pdmVyc2l0eSwgTWFhc3RyaWNodCwgVGhlIE5ldGhl

cmxhbmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBSZWhhYmlsaXRhdGlvbiBNZWRpY2luZSwgTU9WRSBS

ZXNlYXJjaCBJbnN0aXR1dGUgQW1zdGVyZGFtLCBWVSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVy

LCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kcyA7IERlcGFydG1lbnQgb2YgTmV1cm9yZWhhYmls

aXRhdGlvbiwgUmVhZGUgQ2VudGVyIGZvciBSZWhhYmlsaXRhdGlvbiBhbmQgUmhldW1hdG9sb2d5

LCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kcy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5XaGF0IGlzIHRoZSBldmlkZW5jZSBmb3IgcGh5c2ljYWwgdGhlcmFweSBwb3N0c3Ryb2tlPyBB

IHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFuYWx5c2lzPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPlBMb1MgT25lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5QbG9TIG9uZTwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBMb1MgT25lPC9mdWxsLXRpdGxl

PjxhYmJyLTE+UGxvUyBvbmU8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPlBMb1MgT25lPC9mdWxsLXRpdGxlPjxhYmJyLTE+UGxvUyBvbmU8L2FiYnItMT48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz5lODc5ODc8L3BhZ2VzPjx2b2x1bWU+OTwvdm9sdW1lPjxu

dW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMTQvMDIvMDg8L2VkaXRpb24+PGtleXdvcmRzPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NdXNjbGUgU3RyZW5ndGgvcGh5c2lvbG9n

eTwva2V5d29yZD48a2V5d29yZD4qUGh5c2ljYWwgVGhlcmFweSBNb2RhbGl0aWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+

PGtleXdvcmQ+U3Ryb2tlL3BoeXNpb3BhdGhvbG9neS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjxpc2JuPjE5MzItNjIw

MzwvaXNibj48YWNjZXNzaW9uLW51bT4yNDUwNTM0MjwvYWNjZXNzaW9uLW51bT48dXJscz48L3Vy

bHM+PGN1c3RvbTI+UG1jMzkxMzc4NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTM3MS9qb3VybmFsLnBvbmUuMDA4Nzk4NzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVwaGVyZDwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+

PFJlY051bT4yPC9SZWNOdW0+PERpc3BsYXlUZXh0Pls4LTExXTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4yPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9IjE0

NjE3MzEzMzUiPjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNoZXBo

ZXJkLCBSLiBCLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz

PlNjaG9vbCBvZiBQaHlzaW90aGVyYXB5LCBGYWN1bHR5IG9mIEhlYWx0aCBTY2llbmNlcywgVGhl

IFVuaXZlcnNpdHkgb2YgU3lkbmV5LCBBdXN0cmFsaWEuIFIuU2hlcGhlcmRAY2Nocy51c3lkLmVk

dS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkV4ZXJjaXNlIGFuZCB0cmFpbmluZyB0

byBvcHRpbWl6ZSBmdW5jdGlvbmFsIG1vdG9yIHBlcmZvcm1hbmNlIGluIHN0cm9rZTogZHJpdmlu

ZyBuZXVyYWwgcmVvcmdhbml6YXRpb24/PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJhbCBQ

bGFzdDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TmV1cmFsIHBsYXN0aWNpdHk8L2FsdC10

aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXVyYWwgUGxhc3Q8L2Z1bGwt

dGl0bGU+PGFiYnItMT5OZXVyYWwgcGxhc3RpY2l0eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cmFsIFBsYXN0PC9mdWxsLXRpdGxlPjxhYmJyLTE+

TmV1cmFsIHBsYXN0aWNpdHk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMjEtOTwv

cGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PG51bWJlcj4xLTI8L251bWJlcj48ZWRpdGlvbj4yMDAx

LzA5LzA0PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qRXhlcmNpc2UgVGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TmV1cm9uYWwgUGxhc3RpY2l0

eS8qcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlvbi9waHlz

aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS8qcGh5c2lvcGF0aG9sb2d5Lyp0aGVyYXB5

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PC9kYXRlcz48aXNi

bj4yMDkwLTU5MDQgKFByaW50KSYjeEQ7MTY4Ny01NDQzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEx

NTMwODgzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QbWMyNTY1Mzg2PC9j

dXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTU1L25wLjIwMDEuMTIxPC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPlRlYXNlbGw8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNOdW0+

MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz

PjxrZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1

diIgdGltZXN0YW1wPSIxNDYxNzMxNDMwIj4zPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl

IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv

cnM+PGF1dGhvcj5UZWFzZWxsLCBSLjwvYXV0aG9yPjxhdXRob3I+Rm9sZXksIE4uPC9hdXRob3I+

PGF1dGhvcj5TYWx0ZXIsIEsuPC9hdXRob3I+PGF1dGhvcj5CaG9nYWwsIFMuPC9hdXRob3I+PGF1

dGhvcj5KdXRhaSwgSi48L2F1dGhvcj48YXV0aG9yPlNwZWVjaGxleSwgTS48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBoeXNpY2Fs

IE1lZGljaW5lIGFuZCBSZWhhYmlsaXRhdGlvbiwgU3QuIEpvc2VwaCZhcG9zO3MgSGVhbHRoIENh

cmUgTG9uZG9uLCBQYXJrd29vZCBIb3NwaXRhbCwgT250YXJpbywgQ2FuYWRhLjwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPkV2aWRlbmNlLUJhc2VkIFJldmlldyBvZiBTdHJva2UgUmVoYWJp

bGl0YXRpb246IGV4ZWN1dGl2ZSBzdW1tYXJ5LCAxMnRoIGVkaXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+VG9wIFN0cm9rZSBSZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5U

b3BpY3MgaW4gc3Ryb2tlIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+VG9wIFN0cm9rZSBSZWhhYmlsPC9mdWxsLXRpdGxlPjxhYmJyLTE+

VG9waWNzIGluIHN0cm9rZSByZWhhYmlsaXRhdGlvbjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0

LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+VG9wIFN0cm9rZSBSZWhhYmlsPC9mdWxsLXRpdGxlPjxh

YmJyLTE+VG9waWNzIGluIHN0cm9rZSByZWhhYmlsaXRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjQ2My04ODwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+Njwv

bnVtYmVyPjxlZGl0aW9uPjIwMTAvMDIvMDk8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkRh

dGFiYXNlcywgRmFjdHVhbC9zdGF0aXN0aWNzICZhbXA7IG51bWVyaWNhbCBkYXRhPC9rZXl3b3Jk

PjxrZXl3b3JkPipFdmlkZW5jZS1CYXNlZCBNZWRpY2luZTwva2V5d29yZD48a2V5d29yZD5IdW1h

bnM8L2tleXdvcmQ+PGtleXdvcmQ+TWV0YS1BbmFseXNpcyBhcyBUb3BpYzwva2V5d29yZD48a2V5

d29yZD5OZWVkcyBBc3Nlc3NtZW50L3N0YXRpc3RpY3MgJmFtcDsgbnVtZXJpY2FsIGRhdGE8L2tl

eXdvcmQ+PGtleXdvcmQ+KlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllczwva2V5d29yZD48a2V5

d29yZD5SZWhhYmlsaXRhdGlvbiBDZW50ZXJzPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS8qcmVo

YWJpbGl0YXRpb248L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk5vdi1EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4x

MDc0LTkzNTcgKFByaW50KSYjeEQ7MTA3NC05MzU3PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMTM5

MDQ5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTMxMC90c3IxNjA2LTQ2MzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRh

YmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5n

PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5GcmVuY2g8L0F1dGhvcj48

WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+NDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDwv

cmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Aw

c3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYxNzMxNTIyIj40PC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5GcmVuY2gsIEIuPC9hdXRob3I+PGF1

dGhvcj5UaG9tYXMsIEwuIEguPC9hdXRob3I+PGF1dGhvcj5MZWF0aGxleSwgTS4gSi48L2F1dGhv

cj48YXV0aG9yPlN1dHRvbiwgQy4gSi48L2F1dGhvcj48YXV0aG9yPk1jQWRhbSwgSi48L2F1dGhv

cj48YXV0aG9yPkZvcnN0ZXIsIEEuPC9hdXRob3I+PGF1dGhvcj5MYW5naG9ybmUsIFAuPC9hdXRo

b3I+PGF1dGhvcj5QcmljZSwgQy4gSS48L2F1dGhvcj48YXV0aG9yPldhbGtlciwgQS48L2F1dGhv

cj48YXV0aG9yPldhdGtpbnMsIEMuIEwuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBDZW50cmFsIExhbmNhc2hpcmUsIERlcGFydG1l

bnQgb2YgTnVyc2luZywgUHJlc3RvbiwgVUssIFBSMSAySEUuIGJmcmVuY2gxQHVjbGFuLmFjLnVr

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVwZXRpdGl2ZSB0YXNrIHRyYWluaW5nIGZv

ciBpbXByb3ZpbmcgZnVuY3Rpb25hbCBhYmlsaXR5IGFmdGVyIHN0cm9rZTwvdGl0bGU+PHNlY29u

ZGFyeS10aXRsZT5Db2NocmFuZSBEYXRhYmFzZSBTeXN0IFJldjwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+VGhlIENvY2hyYW5lIGRhdGFiYXNlIG9mIHN5c3RlbWF0aWMgcmV2aWV3czwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNvY2hyYW5lIERhdGFiYXNl

IFN5c3QgUmV2PC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhlIENvY2hyYW5lIGRhdGFiYXNlIG9mIHN5

c3RlbWF0aWMgcmV2aWV3czwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1

bGwtdGl0bGU+Q29jaHJhbmUgRGF0YWJhc2UgU3lzdCBSZXY8L2Z1bGwtdGl0bGU+PGFiYnItMT5U

aGUgQ29jaHJhbmUgZGF0YWJhc2Ugb2Ygc3lzdGVtYXRpYyByZXZpZXdzPC9hYmJyLTE+PC9hbHQt

cGVyaW9kaWNhbD48cGFnZXM+Q2QwMDYwNzM8L3BhZ2VzPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0

aW9uPjIwMDcvMTAvMTk8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPipBY3Rpdml0aWVzIG9m

IERhaWx5IExpdmluZzwva2V5d29yZD48a2V5d29yZD5FeHRyZW1pdGllczwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TW90b3IgQWN0aXZpdHk8L2tleXdvcmQ+PGtl

eXdvcmQ+KlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllczwva2V5d29yZD48a2V5d29yZD5SYW5k

b21pemVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPipSZWNv

dmVyeSBvZiBGdW5jdGlvbjwva2V5d29yZD48a2V5d29yZD5TdHJva2UvKnJlaGFiaWxpdGF0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPlRhc2sgUGVyZm9ybWFuY2UgYW5kIEFuYWx5c2lzPC9rZXl3b3Jk

PjxrZXl3b3JkPldhbGtpbmc8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwv

eWVhcj48L2RhdGVzPjxpc2JuPjEzNjEtNjEzNzwvaXNibj48YWNjZXNzaW9uLW51bT4xNzk0Mzg4

MzwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwMDIvMTQ2NTE4NTguQ0QwMDYwNzMucHViMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5WZWVyYmVl

azwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4xMDwvUmVjTnVtPjxyZWNvcmQ+PHJl

Yy1udW1iZXI+MTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk

PSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQyMjAw

NzIyOSI+MTA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp

Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlZlZXJiZWVr

LCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+dmFuIFdlZ2VuLCBFLjwvYXV0aG9yPjxhdXRob3I+dmFu

IFBlcHBlbiwgUi48L2F1dGhvcj48YXV0aG9yPnZhbiBkZXIgV2VlcywgUC4gSi48L2F1dGhvcj48

YXV0aG9yPkhlbmRyaWtzLCBFLjwvYXV0aG9yPjxhdXRob3I+UmlldGJlcmcsIE0uPC9hdXRob3I+

PGF1dGhvcj5Ld2Fra2VsLCBHLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0

aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUmVoYWJpbGl0YXRpb24gTWVkaWNpbmUsIE1PVkUgUmVz

ZWFyY2ggSW5zdGl0dXRlIEFtc3RlcmRhbSwgVlUgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciwg

QW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9mIFBoeXNpb3RoZXJh

cHksIFVuaXZlcnNpdHkgb2YgQXBwbGllZCBTY2llbmNlcyBVdHJlY2h0LCBVdHJlY2h0LCBUaGUg

TmV0aGVybGFuZHMuJiN4RDtTY2llbnRpZmljIEluc3RpdHV0ZSBmb3IgUXVhbGl0eSBvZiBIZWFs

dGhjYXJlIChJUSBoZWFsdGhjYXJlKSwgUmFkYm91ZCBVbml2ZXJzaXR5IE5pam1lZ2VuIE1lZGlj

YWwgQ2VudGVyLCBOaWptZWdlbiwgVGhlIE5ldGhlcmxhbmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBF

cGlkZW1pb2xvZ3ksIE1hYXN0cmljaHQgVW5pdmVyc2l0eSwgTWFhc3RyaWNodCwgVGhlIE5ldGhl

cmxhbmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBSZWhhYmlsaXRhdGlvbiBNZWRpY2luZSwgTU9WRSBS

ZXNlYXJjaCBJbnN0aXR1dGUgQW1zdGVyZGFtLCBWVSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVy

LCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kcyA7IERlcGFydG1lbnQgb2YgTmV1cm9yZWhhYmls

aXRhdGlvbiwgUmVhZGUgQ2VudGVyIGZvciBSZWhhYmlsaXRhdGlvbiBhbmQgUmhldW1hdG9sb2d5

LCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kcy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs

ZT5XaGF0IGlzIHRoZSBldmlkZW5jZSBmb3IgcGh5c2ljYWwgdGhlcmFweSBwb3N0c3Ryb2tlPyBB

IHN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFuYWx5c2lzPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPlBMb1MgT25lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5QbG9TIG9uZTwvYWx0LXRp

dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBMb1MgT25lPC9mdWxsLXRpdGxl

PjxhYmJyLTE+UGxvUyBvbmU8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPlBMb1MgT25lPC9mdWxsLXRpdGxlPjxhYmJyLTE+UGxvUyBvbmU8L2FiYnItMT48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz5lODc5ODc8L3BhZ2VzPjx2b2x1bWU+OTwvdm9sdW1lPjxu

dW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMTQvMDIvMDg8L2VkaXRpb24+PGtleXdvcmRzPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NdXNjbGUgU3RyZW5ndGgvcGh5c2lvbG9n

eTwva2V5d29yZD48a2V5d29yZD4qUGh5c2ljYWwgVGhlcmFweSBNb2RhbGl0aWVzPC9rZXl3b3Jk

PjxrZXl3b3JkPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbHMgYXMgVG9waWM8L2tleXdvcmQ+

PGtleXdvcmQ+U3Ryb2tlL3BoeXNpb3BhdGhvbG9neS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjxpc2JuPjE5MzItNjIw

MzwvaXNibj48YWNjZXNzaW9uLW51bT4yNDUwNTM0MjwvYWNjZXNzaW9uLW51bT48dXJscz48L3Vy

bHM+PGN1c3RvbTI+UG1jMzkxMzc4NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTM3MS9qb3VybmFsLnBvbmUuMDA4Nzk4NzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE.DATA [8-11]. High levels of social support have been associated with better health-related quality of life in individuals with stroke ADDIN EN.CITE <EndNote><Cite><Author>Kruithof</Author><Year>2013</Year><RecNum>114</RecNum><DisplayText>[12]</DisplayText><record><rec-number>114</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1441618527">114</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kruithof, W. J.</author><author>van Mierlo, M. L.</author><author>Visser-Meily, J. M.</author><author>van Heugten, C. M.</author><author>Post, M. W.</author></authors></contributors><auth-address>Rudolf Magnus Institute of Neuroscience and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Utrecht, The Netherlands.</auth-address><titles><title>Associations between social support and stroke survivors&apos; health-related quality of life--a systematic review</title><secondary-title>Patient Educ Couns</secondary-title><alt-title>Patient education and counseling</alt-title></titles><periodical><full-title>Patient Educ Couns</full-title><abbr-1>Patient education and counseling</abbr-1></periodical><alt-periodical><full-title>Patient Educ Couns</full-title><abbr-1>Patient education and counseling</abbr-1></alt-periodical><pages>169-76</pages><volume>93</volume><number>2</number><edition>2013/07/23</edition><keywords><keyword>Humans</keyword><keyword>*Quality of Life</keyword><keyword>*Social Support</keyword><keyword>Stroke/*psychology</keyword><keyword>Survivors/*psychology</keyword><keyword>Quality of life</keyword><keyword>Review</keyword><keyword>Social support</keyword><keyword>Stroke</keyword></keywords><dates><year>2013</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0738-3991</isbn><accession-num>23870177</accession-num><urls></urls><electronic-resource-num>10.1016/j.pec.2013.06.003</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[12] and other medical conditions PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJuZXI8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

ZWNOdW0+MTM8L1JlY051bT48RGlzcGxheVRleHQ+WzEzLCAxNF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJlencwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYiIHRpbWVzdGFtcD0i

MTQ2MTczMzI3NCI+MTM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldh

cm5lciwgRS4gTC48L2F1dGhvcj48YXV0aG9yPktlbnQsIEUuIEUuPC9hdXRob3I+PGF1dGhvcj5U

cmV2aW5vLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+UGFyc29ucywgSC4gTS48L2F1dGhvcj48YXV0

aG9yPlplYnJhY2ssIEIuIEouPC9hdXRob3I+PGF1dGhvcj5LaXJjaGhvZmYsIEEuIEMuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2FuY2VyIENvbnRyb2wg

YW5kIFBvcHVsYXRpb24gU2NpZW5jZXMsIEh1bnRzbWFuIENhbmNlciBJbnN0aXR1dGUsIFNhbHQg

TGFrZSBDaXR5LCBVdGFoLiYjeEQ7T3V0Y29tZXMgUmVzZWFyY2ggQnJhbmNoLCBOYXRpb25hbCBD

YW5jZXIgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCwgQmV0aGVzZGEs

IE1hcnlsYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgV2VpbGwgQ29ybmVsbCBNZWRp

Y2luZSwgTmV3IFlvcmssIE5ldyBZb3JrLiYjeEQ7RGVwYXJ0bWVudCBvZiBFcGlkZW1pb2xvZ3kg

YW5kIEJpb3N0YXRpc3RpY3MsIFVuaXZlcnNpdHkgb2YgVGV4YXMgSGVhbHRoIFNjaWVuY2UgQ2Vu

dGVyLCBTYW4gQW50b25pbywgVGV4YXMuJiN4RDtVbml2ZXJzaXR5IG9mIE1pY2hpZ2FuIFNjaG9v

bCBvZiBTb2NpYWwgV29yaywgQW5uIEFyYm9yLCBNaWNoaWdhbi4mI3hEO0RlcGFydG1lbnQgb2Yg

UGVkaWF0cmljcywgVW5pdmVyc2l0eSBvZiBVdGFoLCBTYWx0IExha2UgQ2l0eSwgVXRhaC48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Tb2NpYWwgd2VsbC1iZWluZyBhbW9uZyBhZG9sZXNj

ZW50cyBhbmQgeW91bmcgYWR1bHRzIHdpdGggY2FuY2VyOiBBIHN5c3RlbWF0aWMgcmV2aWV3PC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

Q2FuY2VyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2FuY2Vy

PC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2FuY2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5DYW5jZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5DYW5jZXI8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMDI5LTM3PC9wYWdlcz48dm9sdW1lPjEyMjwv

dm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9uPjIwMTYvMDIvMDY8L2VkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPmFkb2xlc2NlbnQgYW5kIHlvdW5nIGFkdWx0PC9rZXl3b3JkPjxrZXl3

b3JkPmNhbmNlcjwva2V5d29yZD48a2V5d29yZD5lZHVjYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+

ZW1wbG95bWVudDwva2V5d29yZD48a2V5d29yZD5zb2NpYWwgc3VwcG9ydDwva2V5d29yZD48L2tl

eXdvcmRzPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDE8L2Rh

dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA4LTU0M3g8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MjY4NDg3MTM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDAyL2NuY3IuMjk4NjY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1v

dGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1

YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2lycmk8L0F1

dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+MTQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjE0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3

MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9IjE0NjE3MzMzMjMi

PjE0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TaXJyaSwgTC48L2F1

dGhvcj48YXV0aG9yPk1hZ2VsbGksIEMuPC9hdXRob3I+PGF1dGhvcj5HcmFuZGksIFMuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQ

c3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9mIEJvbG9nbmEsIEJvbG9nbmEsIEl0YWx5LiBsYXVyYXNp

cnJpQGxpYmVyby5pdDwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByZWRpY3RvcnMgb2Yg

cGVyY2VpdmVkIHNvY2lhbCBzdXBwb3J0IGluIGxvbmctdGVybSBzdXJ2aXZvcnMgb2YgY2FyZGlh

YyB0cmFuc3BsYW50OiB0aGUgcm9sZSBvZiBwc3ljaG9sb2dpY2FsIGRpc3RyZXNzLCBxdWFsaXR5

IG9mIGxpZmUsIGRlbW9ncmFwaGljIGNoYXJhY3RlcmlzdGljcyBhbmQgY2xpbmljYWwgY291cnNl

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBzeWNob2wgSGVhbHRoPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5Qc3ljaG9sb2d5ICZhbXA7IGhlYWx0aDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBzeWNob2wgSGVhbHRoPC9mdWxsLXRpdGxlPjxhYmJyLTE+

UHN5Y2hvbG9neSAmYW1wOyBoZWFsdGg8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPlBzeWNob2wgSGVhbHRoPC9mdWxsLXRpdGxlPjxhYmJyLTE+UHN5Y2hv

bG9neSAmYW1wOyBoZWFsdGg8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz43Ny05NDwv

cGFnZXM+PHZvbHVtZT4yNjwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMTAv

MDMvMjQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFydCBUcmFuc3BsYW50YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+

TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KlF1YWxpdHkgb2YgTGlmZTwva2V5d29yZD48

a2V5d29yZD4qU29jaWFsIFN1cHBvcnQ8L2tleXdvcmQ+PGtleXdvcmQ+KlN0cmVzcywgUHN5Y2hv

bG9naWNhbDwva2V5d29yZD48a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5

d29yZD48a2V5d29yZD5TdXJ2aXZvcnMvKnBzeWNob2xvZ3k8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjA4ODctMDQ0NjwvaXNibj48YWNjZXNzaW9uLW51bT4yMDMwOTc4

MjwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwODAvMDg4NzA0NDA5MDMzNzczMzk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdl

PmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4AAD==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJuZXI8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxS

ZWNOdW0+MTM8L1JlY051bT48RGlzcGxheVRleHQ+WzEzLCAxNF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJlencwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYiIHRpbWVzdGFtcD0i

MTQ2MTczMzI3NCI+MTM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldh

cm5lciwgRS4gTC48L2F1dGhvcj48YXV0aG9yPktlbnQsIEUuIEUuPC9hdXRob3I+PGF1dGhvcj5U

cmV2aW5vLCBLLiBNLjwvYXV0aG9yPjxhdXRob3I+UGFyc29ucywgSC4gTS48L2F1dGhvcj48YXV0

aG9yPlplYnJhY2ssIEIuIEouPC9hdXRob3I+PGF1dGhvcj5LaXJjaGhvZmYsIEEuIEMuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2FuY2VyIENvbnRyb2wg

YW5kIFBvcHVsYXRpb24gU2NpZW5jZXMsIEh1bnRzbWFuIENhbmNlciBJbnN0aXR1dGUsIFNhbHQg

TGFrZSBDaXR5LCBVdGFoLiYjeEQ7T3V0Y29tZXMgUmVzZWFyY2ggQnJhbmNoLCBOYXRpb25hbCBD

YW5jZXIgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCwgQmV0aGVzZGEs

IE1hcnlsYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgV2VpbGwgQ29ybmVsbCBNZWRp

Y2luZSwgTmV3IFlvcmssIE5ldyBZb3JrLiYjeEQ7RGVwYXJ0bWVudCBvZiBFcGlkZW1pb2xvZ3kg

YW5kIEJpb3N0YXRpc3RpY3MsIFVuaXZlcnNpdHkgb2YgVGV4YXMgSGVhbHRoIFNjaWVuY2UgQ2Vu

dGVyLCBTYW4gQW50b25pbywgVGV4YXMuJiN4RDtVbml2ZXJzaXR5IG9mIE1pY2hpZ2FuIFNjaG9v

bCBvZiBTb2NpYWwgV29yaywgQW5uIEFyYm9yLCBNaWNoaWdhbi4mI3hEO0RlcGFydG1lbnQgb2Yg

UGVkaWF0cmljcywgVW5pdmVyc2l0eSBvZiBVdGFoLCBTYWx0IExha2UgQ2l0eSwgVXRhaC48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Tb2NpYWwgd2VsbC1iZWluZyBhbW9uZyBhZG9sZXNj

ZW50cyBhbmQgeW91bmcgYWR1bHRzIHdpdGggY2FuY2VyOiBBIHN5c3RlbWF0aWMgcmV2aWV3PC90

aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNhbmNlcjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+

Q2FuY2VyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2FuY2Vy

PC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2FuY2VyPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVy

aW9kaWNhbD48ZnVsbC10aXRsZT5DYW5jZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5DYW5jZXI8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMDI5LTM3PC9wYWdlcz48dm9sdW1lPjEyMjwv

dm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9uPjIwMTYvMDIvMDY8L2VkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPmFkb2xlc2NlbnQgYW5kIHlvdW5nIGFkdWx0PC9rZXl3b3JkPjxrZXl3

b3JkPmNhbmNlcjwva2V5d29yZD48a2V5d29yZD5lZHVjYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+

ZW1wbG95bWVudDwva2V5d29yZD48a2V5d29yZD5zb2NpYWwgc3VwcG9ydDwva2V5d29yZD48L2tl

eXdvcmRzPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDE8L2Rh

dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA4LTU0M3g8L2lzYm4+PGFjY2Vzc2lvbi1u

dW0+MjY4NDg3MTM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDAyL2NuY3IuMjk4NjY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1v

dGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1

YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2lycmk8L0F1

dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNOdW0+MTQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt

YmVyPjE0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3

MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9IjE0NjE3MzMzMjMi

PjE0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+

MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TaXJyaSwgTC48L2F1

dGhvcj48YXV0aG9yPk1hZ2VsbGksIEMuPC9hdXRob3I+PGF1dGhvcj5HcmFuZGksIFMuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQ

c3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9mIEJvbG9nbmEsIEJvbG9nbmEsIEl0YWx5LiBsYXVyYXNp

cnJpQGxpYmVyby5pdDwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlByZWRpY3RvcnMgb2Yg

cGVyY2VpdmVkIHNvY2lhbCBzdXBwb3J0IGluIGxvbmctdGVybSBzdXJ2aXZvcnMgb2YgY2FyZGlh

YyB0cmFuc3BsYW50OiB0aGUgcm9sZSBvZiBwc3ljaG9sb2dpY2FsIGRpc3RyZXNzLCBxdWFsaXR5

IG9mIGxpZmUsIGRlbW9ncmFwaGljIGNoYXJhY3RlcmlzdGljcyBhbmQgY2xpbmljYWwgY291cnNl

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBzeWNob2wgSGVhbHRoPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5Qc3ljaG9sb2d5ICZhbXA7IGhlYWx0aDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBzeWNob2wgSGVhbHRoPC9mdWxsLXRpdGxlPjxhYmJyLTE+

UHN5Y2hvbG9neSAmYW1wOyBoZWFsdGg8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPlBzeWNob2wgSGVhbHRoPC9mdWxsLXRpdGxlPjxhYmJyLTE+UHN5Y2hv

bG9neSAmYW1wOyBoZWFsdGg8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz43Ny05NDwv

cGFnZXM+PHZvbHVtZT4yNjwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMTAv

MDMvMjQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+

RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFydCBUcmFuc3BsYW50YXRpb248L2tleXdvcmQ+

PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+

TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KlF1YWxpdHkgb2YgTGlmZTwva2V5d29yZD48

a2V5d29yZD4qU29jaWFsIFN1cHBvcnQ8L2tleXdvcmQ+PGtleXdvcmQ+KlN0cmVzcywgUHN5Y2hv

bG9naWNhbDwva2V5d29yZD48a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5

d29yZD48a2V5d29yZD5TdXJ2aXZvcnMvKnBzeWNob2xvZ3k8L2tleXdvcmQ+PC9rZXl3b3Jkcz48

ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjA4ODctMDQ0NjwvaXNibj48YWNjZXNzaW9uLW51bT4yMDMwOTc4

MjwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjEwODAvMDg4NzA0NDA5MDMzNzczMzk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdl

PmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4AAD==

ADDIN EN.CITE.DATA [13, 14]. Some studies also suggest an association with improved functional status PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HbGFzczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+PFJl

Y051bT40NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTUsIDE2XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9InMyZjBmejBhb3N0dGZpZXhmOWx4MDlkNDkydHRkdmZ3MmYwciIgdGltZXN0YW1wPSIx

NDIyMTYwODYxIj40NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R2xh

c3MsIFQuIEEuPC9hdXRob3I+PGF1dGhvcj5NYXRjaGFyLCBELiBCLjwvYXV0aG9yPjxhdXRob3I+

QmVseWVhLCBNLjwvYXV0aG9yPjxhdXRob3I+RmV1c3NuZXIsIEouIFIuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFcGlkZW1pb2xv

Z3kgYW5kIFB1YmxpYyBIZWFsdGgsIFlhbGUgVW5pdmVyc2l0eSwgU2Nob29sIG9mIE1lZGljaW5l

LCBOZXcgSGF2ZW4sIENvbm4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW1wYWN0IG9m

IHNvY2lhbCBzdXBwb3J0IG9uIG91dGNvbWUgaW4gZmlyc3Qgc3Ryb2tlPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPlN0cm9rZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+U3Ryb2tlOyBhIGpv

dXJuYWwgb2YgY2VyZWJyYWwgY2lyY3VsYXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91

cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+U3Ryb2tlPC9mdWxsLXRpdGxlPjxhYmJyLTE+U3Ryb2tlOyBh

IGpvdXJuYWwgb2YgY2VyZWJyYWwgY2lyY3VsYXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2Fs

PjxwYWdlcz42NC03MDwvcGFnZXM+PHZvbHVtZT4yNDwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVy

PjxlZGl0aW9uPjE5OTMvMDEvMDE8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRp

ZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdv

cmQ+Q2VyZWJyb3Zhc2N1bGFyIERpc29yZGVycy8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1p

ZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipTb2NpYWwgU3VwcG9ydDwva2V5d29yZD48L2tl

eXdvcmRzPjxkYXRlcz48eWVhcj4xOTkzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5IChQcmludCkmI3hEOzAwMzktMjQ5

OTwvaXNibj48YWNjZXNzaW9uLW51bT44NDE4NTUzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJs

cz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlRz

b3VuYS1IYWRqaXM8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNOdW0+NDc8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iczJmMGZ6MGFvc3R0ZmlleGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1lc3Rh

bXA9IjE0MjIxNjE0NzYiPjQ3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Uc291bmEtSGFkamlzLCBFLjwvYXV0aG9yPjxhdXRob3I+VmVtbW9zLCBLLiBOLjwvYXV0aG9y

PjxhdXRob3I+WmFrb3BvdWxvcywgTi48L2F1dGhvcj48YXV0aG9yPlN0YW1hdGVsb3BvdWxvcywg

Uy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt

ZW50IG9mIENsaW5pY2FsIFRoZXJhcGV1dGljcywgVW5pdmVyc2l0eSBvZiBBdGhlbnMgU2Nob29s

IG9mIE1lZGljaW5lLCBBbGV4YW5kcmEgSG9zcGl0YWwsIEdyZWVjZS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5GaXJzdC1zdHJva2UgcmVjb3ZlcnkgcHJvY2VzczogdGhlIHJvbGUgb2Yg

ZmFtaWx5IHNvY2lhbCBzdXBwb3J0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFyY2ggUGh5cyBN

ZWQgUmVoYWJpbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaGl2ZXMgb2YgcGh5c2lj

YWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9mdWxsLXRpdGxlPjxhYmJy

LTE+QXJjaGl2ZXMgb2YgcGh5c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMgTWVk

IFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2lu

ZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz44ODEt

NzwvcGFnZXM+PHZvbHVtZT44MTwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9uPjIw

MDAvMDcvMTU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtl

eXdvcmQ+KkZhbWlseTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRlIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3

b3JkPipTb2NpYWwgU3VwcG9ydDwva2V5d29yZD48a2V5d29yZD5TdHJva2UvKnJlaGFiaWxpdGF0

aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTMgKFBy

aW50KSYjeEQ7MDAwMy05OTkzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEwODk1OTk5PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1My9hcG1y

LjIwMDAuNDQzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFn

ZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HbGFzczwvQXV0aG9yPjxZZWFyPjE5OTM8L1llYXI+PFJl

Y051bT40NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTUsIDE2XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9InMyZjBmejBhb3N0dGZpZXhmOWx4MDlkNDkydHRkdmZ3MmYwciIgdGltZXN0YW1wPSIx

NDIyMTYwODYxIj40NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R2xh

c3MsIFQuIEEuPC9hdXRob3I+PGF1dGhvcj5NYXRjaGFyLCBELiBCLjwvYXV0aG9yPjxhdXRob3I+

QmVseWVhLCBNLjwvYXV0aG9yPjxhdXRob3I+RmV1c3NuZXIsIEouIFIuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFcGlkZW1pb2xv

Z3kgYW5kIFB1YmxpYyBIZWFsdGgsIFlhbGUgVW5pdmVyc2l0eSwgU2Nob29sIG9mIE1lZGljaW5l

LCBOZXcgSGF2ZW4sIENvbm4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW1wYWN0IG9m

IHNvY2lhbCBzdXBwb3J0IG9uIG91dGNvbWUgaW4gZmlyc3Qgc3Ryb2tlPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPlN0cm9rZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+U3Ryb2tlOyBhIGpv

dXJuYWwgb2YgY2VyZWJyYWwgY2lyY3VsYXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k

aWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91

cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+U3Ryb2tlPC9mdWxsLXRpdGxlPjxhYmJyLTE+U3Ryb2tlOyBh

IGpvdXJuYWwgb2YgY2VyZWJyYWwgY2lyY3VsYXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2Fs

PjxwYWdlcz42NC03MDwvcGFnZXM+PHZvbHVtZT4yNDwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVy

PjxlZGl0aW9uPjE5OTMvMDEvMDE8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRp

ZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdv

cmQ+Q2VyZWJyb3Zhc2N1bGFyIERpc29yZGVycy8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtl

eXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1p

ZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPipTb2NpYWwgU3VwcG9ydDwva2V5d29yZD48L2tl

eXdvcmRzPjxkYXRlcz48eWVhcj4xOTkzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuPC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5IChQcmludCkmI3hEOzAwMzktMjQ5

OTwvaXNibj48YWNjZXNzaW9uLW51bT44NDE4NTUzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJs

cz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlRz

b3VuYS1IYWRqaXM8L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxSZWNOdW0+NDc8L1JlY051bT48

cmVjb3JkPjxyZWMtbnVtYmVyPjQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iczJmMGZ6MGFvc3R0ZmlleGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1lc3Rh

bXA9IjE0MjIxNjE0NzYiPjQ3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Uc291bmEtSGFkamlzLCBFLjwvYXV0aG9yPjxhdXRob3I+VmVtbW9zLCBLLiBOLjwvYXV0aG9y

PjxhdXRob3I+WmFrb3BvdWxvcywgTi48L2F1dGhvcj48YXV0aG9yPlN0YW1hdGVsb3BvdWxvcywg

Uy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt

ZW50IG9mIENsaW5pY2FsIFRoZXJhcGV1dGljcywgVW5pdmVyc2l0eSBvZiBBdGhlbnMgU2Nob29s

IG9mIE1lZGljaW5lLCBBbGV4YW5kcmEgSG9zcGl0YWwsIEdyZWVjZS48L2F1dGgtYWRkcmVzcz48

dGl0bGVzPjx0aXRsZT5GaXJzdC1zdHJva2UgcmVjb3ZlcnkgcHJvY2VzczogdGhlIHJvbGUgb2Yg

ZmFtaWx5IHNvY2lhbCBzdXBwb3J0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFyY2ggUGh5cyBN

ZWQgUmVoYWJpbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaGl2ZXMgb2YgcGh5c2lj

YWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9mdWxsLXRpdGxlPjxhYmJy

LTE+QXJjaGl2ZXMgb2YgcGh5c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hYmJy

LTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMgTWVk

IFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2lu

ZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz44ODEt

NzwvcGFnZXM+PHZvbHVtZT44MTwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9uPjIw

MDAvMDcvMTU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtl

eXdvcmQ+KkZhbWlseTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRlIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3

b3JkPipTb2NpYWwgU3VwcG9ydDwva2V5d29yZD48a2V5d29yZD5TdHJva2UvKnJlaGFiaWxpdGF0

aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTMgKFBy

aW50KSYjeEQ7MDAwMy05OTkzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEwODk1OTk5PC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1My9hcG1y

LjIwMDAuNDQzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFn

ZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE.DATA [15, 16] perhaps mediated via assistance and increased support to comply with treatments PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uc291bmEtSGFkamlzPC9BdXRob3I+PFllYXI+MjAwMDwv

WWVhcj48UmVjTnVtPjQ3PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxNiwgMTddPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iczJmMGZ6MGFvc3R0ZmlleGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1l

c3RhbXA9IjE0MjIxNjE0NzYiPjQ3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Uc291bmEtSGFkamlzLCBFLjwvYXV0aG9yPjxhdXRob3I+VmVtbW9zLCBLLiBOLjwvYXV0

aG9yPjxhdXRob3I+WmFrb3BvdWxvcywgTi48L2F1dGhvcj48YXV0aG9yPlN0YW1hdGVsb3BvdWxv

cywgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBh

cnRtZW50IG9mIENsaW5pY2FsIFRoZXJhcGV1dGljcywgVW5pdmVyc2l0eSBvZiBBdGhlbnMgU2No

b29sIG9mIE1lZGljaW5lLCBBbGV4YW5kcmEgSG9zcGl0YWwsIEdyZWVjZS48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5GaXJzdC1zdHJva2UgcmVjb3ZlcnkgcHJvY2VzczogdGhlIHJvbGUg

b2YgZmFtaWx5IHNvY2lhbCBzdXBwb3J0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFyY2ggUGh5

cyBNZWQgUmVoYWJpbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaGl2ZXMgb2YgcGh5

c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9mdWxsLXRpdGxlPjxh

YmJyLTE+QXJjaGl2ZXMgb2YgcGh5c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9h

YmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMg

TWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRp

Y2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz44

ODEtNzwvcGFnZXM+PHZvbHVtZT44MTwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9u

PjIwMDAvMDcvMTU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+

PGtleXdvcmQ+KkZhbWlseTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxl

IEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRlIEFuYWx5c2lzPC9rZXl3b3JkPjxr

ZXl3b3JkPipTb2NpYWwgU3VwcG9ydDwva2V5d29yZD48a2V5d29yZD5TdHJva2UvKnJlaGFiaWxp

dGF0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTMg

KFByaW50KSYjeEQ7MDAwMy05OTkzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEwODk1OTk5PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1My9h

cG1yLjIwMDAuNDQzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYXJyaXM8L0F1dGhvcj48WWVhcj4y

MDEwPC9ZZWFyPjxSZWNOdW0+NDQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ0PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczJmMGZ6MGFvc3R0Zmll

eGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1lc3RhbXA9IjE0MjIxNjA3NTciPjQ0PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYXJyaXMsIEouIEUuPC9hdXRob3I+PGF1

dGhvcj5FbmcsIEouIEouPC9hdXRob3I+PGF1dGhvcj5NaWxsZXIsIFcuIEMuPC9hdXRob3I+PGF1

dGhvcj5EYXdzb24sIEEuIFMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+VG9yb250byBSZWhhYmlsaXRhdGlvbiBJbnN0aXR1dGUsIFRvcm9udG8sIE9udGFy

aW8sIENhbmFkYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgcm9sZSBvZiBjYXJl

Z2l2ZXIgaW52b2x2ZW1lbnQgaW4gdXBwZXItbGltYiB0cmVhdG1lbnQgaW4gaW5kaXZpZHVhbHMg

d2l0aCBzdWJhY3V0ZSBzdHJva2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UGh5cyBUaGVyPC9z

ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5QaHlzaWNhbCB0aGVyYXB5PC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UGh5cyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJy

LTE+UGh5c2ljYWwgdGhlcmFweTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+UGh5cyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJyLTE+UGh5c2ljYWwgdGhlcmFw

eTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEzMDItMTA8L3BhZ2VzPjx2b2x1bWU+

OTA8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48ZWRpdGlvbj4yMDEwLzA3LzAyPC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZh

cmlhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFybS8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPipDYXJlZ2l2ZXJzPC9rZXl3b3JkPjxrZXl3b3JkPkNoaS1TcXVhcmUgRGlzdHJpYnV0

aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD4qUGh5c2ljYWwgVGhlcmFweSBN

b2RhbGl0aWVzPC9rZXl3b3JkPjxrZXl3b3JkPipSb2xlPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9r

ZS9waHlzaW9wYXRob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0

bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDMx

LTkwMjM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjA1OTIyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+

PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4yNTIyL3B0ai4yMDA5MDM0OTwvZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uc291bmEtSGFkamlzPC9BdXRob3I+PFllYXI+MjAwMDwv

WWVhcj48UmVjTnVtPjQ3PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxNiwgMTddPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjQ3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0iczJmMGZ6MGFvc3R0ZmlleGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1l

c3RhbXA9IjE0MjIxNjE0NzYiPjQ3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9

IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1

dGhvcj5Uc291bmEtSGFkamlzLCBFLjwvYXV0aG9yPjxhdXRob3I+VmVtbW9zLCBLLiBOLjwvYXV0

aG9yPjxhdXRob3I+WmFrb3BvdWxvcywgTi48L2F1dGhvcj48YXV0aG9yPlN0YW1hdGVsb3BvdWxv

cywgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBh

cnRtZW50IG9mIENsaW5pY2FsIFRoZXJhcGV1dGljcywgVW5pdmVyc2l0eSBvZiBBdGhlbnMgU2No

b29sIG9mIE1lZGljaW5lLCBBbGV4YW5kcmEgSG9zcGl0YWwsIEdyZWVjZS48L2F1dGgtYWRkcmVz

cz48dGl0bGVzPjx0aXRsZT5GaXJzdC1zdHJva2UgcmVjb3ZlcnkgcHJvY2VzczogdGhlIHJvbGUg

b2YgZmFtaWx5IHNvY2lhbCBzdXBwb3J0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFyY2ggUGh5

cyBNZWQgUmVoYWJpbDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaGl2ZXMgb2YgcGh5

c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9mdWxsLXRpdGxlPjxh

YmJyLTE+QXJjaGl2ZXMgb2YgcGh5c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9h

YmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMg

TWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRp

Y2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz44

ODEtNzwvcGFnZXM+PHZvbHVtZT44MTwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVyPjxlZGl0aW9u

PjIwMDAvMDcvMTU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+

PGtleXdvcmQ+KkZhbWlseTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxl

IEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TXVsdGl2YXJpYXRlIEFuYWx5c2lzPC9rZXl3b3JkPjxr

ZXl3b3JkPipTb2NpYWwgU3VwcG9ydDwva2V5d29yZD48a2V5d29yZD5TdHJva2UvKnJlaGFiaWxp

dGF0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTMg

KFByaW50KSYjeEQ7MDAwMy05OTkzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEwODk1OTk5PC9hY2Nl

c3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1My9h

cG1yLjIwMDAuNDQzNTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5n

dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYXJyaXM8L0F1dGhvcj48WWVhcj4y

MDEwPC9ZZWFyPjxSZWNOdW0+NDQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjQ0PC9yZWMt

bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iczJmMGZ6MGFvc3R0Zmll

eGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1lc3RhbXA9IjE0MjIxNjA3NTciPjQ0PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYXJyaXMsIEouIEUuPC9hdXRob3I+PGF1

dGhvcj5FbmcsIEouIEouPC9hdXRob3I+PGF1dGhvcj5NaWxsZXIsIFcuIEMuPC9hdXRob3I+PGF1

dGhvcj5EYXdzb24sIEEuIFMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+VG9yb250byBSZWhhYmlsaXRhdGlvbiBJbnN0aXR1dGUsIFRvcm9udG8sIE9udGFy

aW8sIENhbmFkYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgcm9sZSBvZiBjYXJl

Z2l2ZXIgaW52b2x2ZW1lbnQgaW4gdXBwZXItbGltYiB0cmVhdG1lbnQgaW4gaW5kaXZpZHVhbHMg

d2l0aCBzdWJhY3V0ZSBzdHJva2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UGh5cyBUaGVyPC9z

ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5QaHlzaWNhbCB0aGVyYXB5PC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UGh5cyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJy

LTE+UGh5c2ljYWwgdGhlcmFweTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+UGh5cyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJyLTE+UGh5c2ljYWwgdGhlcmFw

eTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEzMDItMTA8L3BhZ2VzPjx2b2x1bWU+

OTA8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48ZWRpdGlvbj4yMDEwLzA3LzAyPC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZh

cmlhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFybS8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxr

ZXl3b3JkPipDYXJlZ2l2ZXJzPC9rZXl3b3JkPjxrZXl3b3JkPkNoaS1TcXVhcmUgRGlzdHJpYnV0

aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl

eXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD4qUGh5c2ljYWwgVGhlcmFweSBN

b2RhbGl0aWVzPC9rZXl3b3JkPjxrZXl3b3JkPipSb2xlPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9r

ZS9waHlzaW9wYXRob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0

bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDMx

LTkwMjM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjA1OTIyNjg8L2FjY2Vzc2lvbi1udW0+PHVybHM+

PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4yNTIyL3B0ai4yMDA5MDM0OTwvZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE.DATA [16, 17]). Even less evidence is available regarding the impact of cognitive engagement, but it has been reported that listening to music can improve focused attention, memory, language, mood and unilateral neglect PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXJrYW1vPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48

UmVjTnVtPjQ4PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxOC0yMF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NDg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0i

MTQyMjE2MjAyNiI+NDg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNh

cmthbW8sIFQuPC9hdXRob3I+PGF1dGhvcj5UZXJ2YW5pZW1pLCBNLjwvYXV0aG9yPjxhdXRob3I+

TGFpdGluZW4sIFMuPC9hdXRob3I+PGF1dGhvcj5Gb3JzYmxvbSwgQS48L2F1dGhvcj48YXV0aG9y

PlNvaW5pbGEsIFMuPC9hdXRob3I+PGF1dGhvcj5NaWtrb25lbiwgTS48L2F1dGhvcj48YXV0aG9y

PkF1dHRpLCBULjwvYXV0aG9yPjxhdXRob3I+U2lsdmVubm9pbmVuLCBILiBNLjwvYXV0aG9yPjxh

dXRob3I+RXJra2lsYSwgSi48L2F1dGhvcj48YXV0aG9yPkxhaW5lLCBNLjwvYXV0aG9yPjxhdXRo

b3I+UGVyZXR6LCBJLjwvYXV0aG9yPjxhdXRob3I+SGlldGFuZW4sIE0uPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q29nbml0aXZlIEJyYWluIFJlc2VhcmNo

IFVuaXQsIERlcGFydG1lbnQgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBvZiBIZWxzaW5raSwg

YW5kIEhlbHNpbmtpIEJyYWluIFJlc2VhcmNoIENlbnRyZSwgSGVsc2lua2ksIEZpbmxhbmQuIHRl

cHBvLnNhcmthbW9AaGVsc2lua2kuZmk8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5NdXNp

YyBsaXN0ZW5pbmcgZW5oYW5jZXMgY29nbml0aXZlIHJlY292ZXJ5IGFuZCBtb29kIGFmdGVyIG1p

ZGRsZSBjZXJlYnJhbCBhcnRlcnkgc3Ryb2tlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJyYWlu

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CcmFpbiA6IGEgam91cm5hbCBvZiBuZXVyb2xv

Z3k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CcmFpbjwvZnVs

bC10aXRsZT48YWJici0xPkJyYWluIDogYSBqb3VybmFsIG9mIG5ldXJvbG9neTwvYWJici0xPjwv

cGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJhaW48L2Z1bGwtdGl0bGU+

PGFiYnItMT5CcmFpbiA6IGEgam91cm5hbCBvZiBuZXVyb2xvZ3k8L2FiYnItMT48L2FsdC1wZXJp

b2RpY2FsPjxwYWdlcz44NjYtNzY8L3BhZ2VzPjx2b2x1bWU+MTMxPC92b2x1bWU+PG51bWJlcj5Q

dCAzPC9udW1iZXI+PGVkaXRpb24+MjAwOC8wMi8yMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWNvdXN0aWMgU3RpbXVsYXRpb24vbWV0aG9kczwva2V5d29yZD48a2V5d29yZD4qQWZmZWN0

PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXR0ZW50aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkNvZ25pdGlvbiBEaXNvcmRlcnMvZXRpb2xvZ3kvKnJlaGFiaWxpdGF0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZWFsdGggU3RhdHVz

IEluZGljYXRvcnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPklu

ZmFyY3Rpb24sIE1pZGRsZSBDZXJlYnJhbCBBcnRlcnkvcHN5Y2hvbG9neS8qcmVoYWJpbGl0YXRp

b248L2tleXdvcmQ+PGtleXdvcmQ+TGFuZ3VhZ2UgVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5N

YWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1lbW9yeTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdl

ZDwva2V5d29yZD48a2V5d29yZD5NdXNpYyBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPk5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0czwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IG9m

IExpZmU8L2tleXdvcmQ+PGtleXdvcmQ+U2luZ2xlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5

d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDAwNi04OTUwPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4Mjg3MTIyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9icmFpbi9h

d24wMTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+

TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+VHNhaTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

PFJlY051bT41MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTE8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5

MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQyMjE2MjUwNSI+NTE8L2tleT48L2ZvcmVpZ24ta2V5

cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1

dG9ycz48YXV0aG9ycz48YXV0aG9yPlRzYWksIFAuIEwuPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBN

LiBDLjwvYXV0aG9yPjxhdXRob3I+SHVhbmcsIFkuIFQuPC9hdXRob3I+PGF1dGhvcj5MaW4sIEsu

IEMuPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBLLiBMLjwvYXV0aG9yPjxhdXRob3I+SHN1LCBZLiBX

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1l

bnQgb2YgT2NjdXBhdGlvbmFsIFRoZXJhcHksIE5hdGlvbmFsIENoZW5nIEt1bmcgVW5pdmVyc2l0

eSwgVGFpbmFuIENpdHkgNzAxIFRhaXdhbi4gcGx0c2FpQG1haWwubmNrdS5lZHUudHc8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MaXN0ZW5pbmcgdG8gY2xhc3NpY2FsIG11c2ljIGFtZWxp

b3JhdGVzIHVuaWxhdGVyYWwgbmVnbGVjdCBhZnRlciBzdHJva2U8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+QW0gSiBPY2N1cCBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgQW1l

cmljYW4gam91cm5hbCBvZiBvY2N1cGF0aW9uYWwgdGhlcmFweSA6IG9mZmljaWFsIHB1YmxpY2F0

aW9uIG9mIHRoZSBBbWVyaWNhbiBPY2N1cGF0aW9uYWwgVGhlcmFweSBBc3NvY2lhdGlvbjwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtIEogT2NjdXAgVGhlcjwv

ZnVsbC10aXRsZT48YWJici0xPlRoZSBBbWVyaWNhbiBqb3VybmFsIG9mIG9jY3VwYXRpb25hbCB0

aGVyYXB5IDogb2ZmaWNpYWwgcHVibGljYXRpb24gb2YgdGhlIEFtZXJpY2FuIE9jY3VwYXRpb25h

bCBUaGVyYXB5IEFzc29jaWF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5BbSBKIE9jY3VwIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgQW1l

cmljYW4gam91cm5hbCBvZiBvY2N1cGF0aW9uYWwgdGhlcmFweSA6IG9mZmljaWFsIHB1YmxpY2F0

aW9uIG9mIHRoZSBBbWVyaWNhbiBPY2N1cGF0aW9uYWwgVGhlcmFweSBBc3NvY2lhdGlvbjwvYWJi

ci0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjMyOC0zNTwvcGFnZXM+PHZvbHVtZT42Nzwvdm9s

dW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMDQvMjA8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW5hbHlzaXMgb2YgVmFyaWFuY2U8

L2tleXdvcmQ+PGtleXdvcmQ+QXJvdXNhbC9waHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkF0

dGVudGlvbi9waHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5

d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5IZW1pcGxlZ2lhL2V0aW9s

b2d5LypyZWhhYmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29y

ZD5NdXNpYyBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlBzeWNob21vdG9yIFBl

cmZvcm1hbmNlL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2FtcGxpbmcgU3R1ZGllczwv

a2V5d29yZD48a2V5d29yZD5TdHJva2UvY29tcGxpY2F0aW9ucy8qcmVoYWJpbGl0YXRpb248L2tl

eXdvcmQ+PGtleXdvcmQ+VGFzayBQZXJmb3JtYW5jZSBhbmQgQW5hbHlzaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heS1KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9k

YXRlcz48aXNibj4wMjcyLTk0OTA8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM1OTc2OTE8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC41MDE0L2Fq

b3QuMjAxMy4wMDYzMTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2Ut

cHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFu

Z3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2Fya2FtbzwvQXV0aG9yPjxZZWFy

PjIwMTQ8L1llYXI+PFJlY051bT40OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDk8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRm

aWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQyMjE2MjIzNiI+NDk8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhcmthbW8sIFQuPC9hdXRob3I+PGF1

dGhvcj5SaXBvbGxlcywgUC48L2F1dGhvcj48YXV0aG9yPlZlcHNhbGFpbmVuLCBILjwvYXV0aG9y

PjxhdXRob3I+QXV0dGksIFQuPC9hdXRob3I+PGF1dGhvcj5TaWx2ZW5ub2luZW4sIEguIE0uPC9h

dXRob3I+PGF1dGhvcj5TYWxsaSwgRS48L2F1dGhvcj48YXV0aG9yPkxhaXRpbmVuLCBTLjwvYXV0

aG9yPjxhdXRob3I+Rm9yc2Jsb20sIEEuPC9hdXRob3I+PGF1dGhvcj5Tb2luaWxhLCBTLjwvYXV0

aG9yPjxhdXRob3I+Um9kcmlndWV6LUZvcm5lbGxzLCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNvZ25pdGl2ZSBCcmFpbiBSZXNlYXJjaCBVbml0LCBD

b2duaXRpdmUgU2NpZW5jZSwgSW5zdGl0dXRlIG9mIEJlaGF2aW91cmFsIFNjaWVuY2VzLCBVbml2

ZXJzaXR5IG9mIEhlbHNpbmtpICwgSGVsc2lua2kgLCBGaW5sYW5kIDsgRmlubmlzaCBDZW50cmUg

b2YgSW50ZXJkaXNjaXBsaW5hcnkgTXVzaWMgUmVzZWFyY2gsIFVuaXZlcnNpdHkgb2YgSGVsc2lu

a2kgLCBIZWxzaW5raSAsIEZpbmxhbmQuJiN4RDtDb2duaXRpb24gYW5kIEJyYWluIFBsYXN0aWNp

dHkgR3JvdXAsIEJlbGx2aXRnZSBCaW9tZWRpY2FsIFJlc2VhcmNoIEluc3RpdHV0ZSAoSURJQkVM

TCksIEwmYXBvcztIb3NwaXRhbGV0IGRlIExsb2JyZWdhdCAsIEJhcmNlbG9uYSAsIFNwYWluIDsg

RGVwYXJ0bWVudCBvZiBCYXNpYyBQc3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9mIEJhcmNlbG9uYSAs

IEJhcmNlbG9uYSAsIFNwYWluLiYjeEQ7Q29nbml0aXZlIEJyYWluIFJlc2VhcmNoIFVuaXQsIENv

Z25pdGl2ZSBTY2llbmNlLCBJbnN0aXR1dGUgb2YgQmVoYXZpb3VyYWwgU2NpZW5jZXMsIFVuaXZl

cnNpdHkgb2YgSGVsc2lua2kgLCBIZWxzaW5raSAsIEZpbmxhbmQuJiN4RDtEZXBhcnRtZW50IG9m

IFJhZGlvbG9neSwgSFVTIE1lZGljYWwgSW1hZ2luZyBDZW50ZXIsIEhlbHNpbmtpIFVuaXZlcnNp

dHkgQ2VudHJhbCBIb3NwaXRhbCwgVW5pdmVyc2l0eSBvZiBIZWxzaW5raSAsIEhlbHNpbmtpICwg

RmlubGFuZC4mI3hEO01paW5hIFNpbGxhbnBhYSBGb3VuZGF0aW9uICwgSGVsc2lua2kgLCBGaW5s

YW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBNdXNpYywgVW5pdmVyc2l0eSBvZiBKeXZhc2t5bGEgLCBK

eXZhc2t5bGEgLCBGaW5sYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBOZXVyb2xvZ3ksIFR1cmt1IFVu

aXZlcnNpdHkgSG9zcGl0YWwgLCBUdXJrdSAsIEZpbmxhbmQuJiN4RDtDb2duaXRpb24gYW5kIEJy

YWluIFBsYXN0aWNpdHkgR3JvdXAsIEJlbGx2aXRnZSBCaW9tZWRpY2FsIFJlc2VhcmNoIEluc3Rp

dHV0ZSAoSURJQkVMTCksIEwmYXBvcztIb3NwaXRhbGV0IGRlIExsb2JyZWdhdCAsIEJhcmNlbG9u

YSAsIFNwYWluIDsgRGVwYXJ0bWVudCBvZiBCYXNpYyBQc3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9m

IEJhcmNlbG9uYSAsIEJhcmNlbG9uYSAsIFNwYWluIDsgSW5zdGl0dWNpbyBDYXRhbGFuYSBkZSBS

ZWNlcmNhIGkgRXN0dWRpcyBBdmFuY2F0cyAoSUNSRUEpICwgQmFyY2Vsb25hICwgU3BhaW4uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U3RydWN0dXJhbCBjaGFuZ2VzIGluZHVjZWQgYnkg

ZGFpbHkgbXVzaWMgbGlzdGVuaW5nIGluIHRoZSByZWNvdmVyaW5nIGJyYWluIGFmdGVyIG1pZGRs

ZSBjZXJlYnJhbCBhcnRlcnkgc3Ryb2tlOiBhIHZveGVsLWJhc2VkIG1vcnBob21ldHJ5IHN0dWR5

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkZyb250IEh1bSBOZXVyb3NjaTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+RnJvbnRpZXJzIGluIGh1bWFuIG5ldXJvc2NpZW5jZTwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkZyb250IEh1bSBOZXVyb3NjaTwvZnVs

bC10aXRsZT48YWJici0xPkZyb250aWVycyBpbiBodW1hbiBuZXVyb3NjaWVuY2U8L2FiYnItMT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkZyb250IEh1bSBOZXVyb3Nj

aTwvZnVsbC10aXRsZT48YWJici0xPkZyb250aWVycyBpbiBodW1hbiBuZXVyb3NjaWVuY2U8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yNDU8L3BhZ2VzPjx2b2x1bWU+ODwvdm9sdW1l

PjxlZGl0aW9uPjIwMTQvMDUvMjc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPmVudmlyb25t

ZW50YWwgZW5yaWNobWVudDwva2V5d29yZD48a2V5d29yZD5tYWduZXRpYyByZXNvbmFuY2UgaW1h

Z2luZzwva2V5d29yZD48a2V5d29yZD5tdXNpYzwva2V5d29yZD48a2V5d29yZD5uZXVyb3BsYXN0

aWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+cmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+

c3BlZWNoPC9rZXl3b3JkPjxrZXl3b3JkPnN0cm9rZTwva2V5d29yZD48a2V5d29yZD52b3hlbC1i

YXNlZCBtb3JwaG9tZXRyeTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95

ZWFyPjwvZGF0ZXM+PGlzYm4+MTY2Mi01MTYxPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0ODYwNDY2

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QbWM0MDI5MDIwPC9jdXN0b20y

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4zMzg5L2ZuaHVtLjIwMTQuMDAyNDU8L2VsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4AAD==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXJrYW1vPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48

UmVjTnVtPjQ4PC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxOC0yMF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NDg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0i

MTQyMjE2MjAyNiI+NDg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNh

cmthbW8sIFQuPC9hdXRob3I+PGF1dGhvcj5UZXJ2YW5pZW1pLCBNLjwvYXV0aG9yPjxhdXRob3I+

TGFpdGluZW4sIFMuPC9hdXRob3I+PGF1dGhvcj5Gb3JzYmxvbSwgQS48L2F1dGhvcj48YXV0aG9y

PlNvaW5pbGEsIFMuPC9hdXRob3I+PGF1dGhvcj5NaWtrb25lbiwgTS48L2F1dGhvcj48YXV0aG9y

PkF1dHRpLCBULjwvYXV0aG9yPjxhdXRob3I+U2lsdmVubm9pbmVuLCBILiBNLjwvYXV0aG9yPjxh

dXRob3I+RXJra2lsYSwgSi48L2F1dGhvcj48YXV0aG9yPkxhaW5lLCBNLjwvYXV0aG9yPjxhdXRo

b3I+UGVyZXR6LCBJLjwvYXV0aG9yPjxhdXRob3I+SGlldGFuZW4sIE0uPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q29nbml0aXZlIEJyYWluIFJlc2VhcmNo

IFVuaXQsIERlcGFydG1lbnQgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBvZiBIZWxzaW5raSwg

YW5kIEhlbHNpbmtpIEJyYWluIFJlc2VhcmNoIENlbnRyZSwgSGVsc2lua2ksIEZpbmxhbmQuIHRl

cHBvLnNhcmthbW9AaGVsc2lua2kuZmk8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5NdXNp

YyBsaXN0ZW5pbmcgZW5oYW5jZXMgY29nbml0aXZlIHJlY292ZXJ5IGFuZCBtb29kIGFmdGVyIG1p

ZGRsZSBjZXJlYnJhbCBhcnRlcnkgc3Ryb2tlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJyYWlu

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CcmFpbiA6IGEgam91cm5hbCBvZiBuZXVyb2xv

Z3k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CcmFpbjwvZnVs

bC10aXRsZT48YWJici0xPkJyYWluIDogYSBqb3VybmFsIG9mIG5ldXJvbG9neTwvYWJici0xPjwv

cGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJhaW48L2Z1bGwtdGl0bGU+

PGFiYnItMT5CcmFpbiA6IGEgam91cm5hbCBvZiBuZXVyb2xvZ3k8L2FiYnItMT48L2FsdC1wZXJp

b2RpY2FsPjxwYWdlcz44NjYtNzY8L3BhZ2VzPjx2b2x1bWU+MTMxPC92b2x1bWU+PG51bWJlcj5Q

dCAzPC9udW1iZXI+PGVkaXRpb24+MjAwOC8wMi8yMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdv

cmQ+QWNvdXN0aWMgU3RpbXVsYXRpb24vbWV0aG9kczwva2V5d29yZD48a2V5d29yZD4qQWZmZWN0

PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QXR0ZW50aW9uPC9rZXl3

b3JkPjxrZXl3b3JkPkNvZ25pdGlvbiBEaXNvcmRlcnMvZXRpb2xvZ3kvKnJlaGFiaWxpdGF0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZWFsdGggU3RhdHVz

IEluZGljYXRvcnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPklu

ZmFyY3Rpb24sIE1pZGRsZSBDZXJlYnJhbCBBcnRlcnkvcHN5Y2hvbG9neS8qcmVoYWJpbGl0YXRp

b248L2tleXdvcmQ+PGtleXdvcmQ+TGFuZ3VhZ2UgVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5N

YWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1lbW9yeTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdl

ZDwva2V5d29yZD48a2V5d29yZD5NdXNpYyBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3

b3JkPk5ldXJvcHN5Y2hvbG9naWNhbCBUZXN0czwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IG9m

IExpZmU8L2tleXdvcmQ+PGtleXdvcmQ+U2luZ2xlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5

d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y

MDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDAwNi04OTUwPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4Mjg3MTIyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5My9icmFpbi9h

d24wMTM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+

TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9y

ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+VHNhaTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+

PFJlY051bT41MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTE8L3JlYy1udW1iZXI+PGZv

cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5

MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQyMjE2MjUwNSI+NTE8L2tleT48L2ZvcmVpZ24ta2V5

cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1

dG9ycz48YXV0aG9ycz48YXV0aG9yPlRzYWksIFAuIEwuPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBN

LiBDLjwvYXV0aG9yPjxhdXRob3I+SHVhbmcsIFkuIFQuPC9hdXRob3I+PGF1dGhvcj5MaW4sIEsu

IEMuPC9hdXRob3I+PGF1dGhvcj5DaGVuLCBLLiBMLjwvYXV0aG9yPjxhdXRob3I+SHN1LCBZLiBX

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1l

bnQgb2YgT2NjdXBhdGlvbmFsIFRoZXJhcHksIE5hdGlvbmFsIENoZW5nIEt1bmcgVW5pdmVyc2l0

eSwgVGFpbmFuIENpdHkgNzAxIFRhaXdhbi4gcGx0c2FpQG1haWwubmNrdS5lZHUudHc8L2F1dGgt

YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MaXN0ZW5pbmcgdG8gY2xhc3NpY2FsIG11c2ljIGFtZWxp

b3JhdGVzIHVuaWxhdGVyYWwgbmVnbGVjdCBhZnRlciBzdHJva2U8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+QW0gSiBPY2N1cCBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5UaGUgQW1l

cmljYW4gam91cm5hbCBvZiBvY2N1cGF0aW9uYWwgdGhlcmFweSA6IG9mZmljaWFsIHB1YmxpY2F0

aW9uIG9mIHRoZSBBbWVyaWNhbiBPY2N1cGF0aW9uYWwgVGhlcmFweSBBc3NvY2lhdGlvbjwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtIEogT2NjdXAgVGhlcjwv

ZnVsbC10aXRsZT48YWJici0xPlRoZSBBbWVyaWNhbiBqb3VybmFsIG9mIG9jY3VwYXRpb25hbCB0

aGVyYXB5IDogb2ZmaWNpYWwgcHVibGljYXRpb24gb2YgdGhlIEFtZXJpY2FuIE9jY3VwYXRpb25h

bCBUaGVyYXB5IEFzc29jaWF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5BbSBKIE9jY3VwIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgQW1l

cmljYW4gam91cm5hbCBvZiBvY2N1cGF0aW9uYWwgdGhlcmFweSA6IG9mZmljaWFsIHB1YmxpY2F0

aW9uIG9mIHRoZSBBbWVyaWNhbiBPY2N1cGF0aW9uYWwgVGhlcmFweSBBc3NvY2lhdGlvbjwvYWJi

ci0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjMyOC0zNTwvcGFnZXM+PHZvbHVtZT42Nzwvdm9s

dW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMDQvMjA8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW5hbHlzaXMgb2YgVmFyaWFuY2U8

L2tleXdvcmQ+PGtleXdvcmQ+QXJvdXNhbC9waHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkF0

dGVudGlvbi9waHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5

d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5IZW1pcGxlZ2lhL2V0aW9s

b2d5LypyZWhhYmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29y

ZD5NdXNpYyBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlBzeWNob21vdG9yIFBl

cmZvcm1hbmNlL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2FtcGxpbmcgU3R1ZGllczwv

a2V5d29yZD48a2V5d29yZD5TdHJva2UvY29tcGxpY2F0aW9ucy8qcmVoYWJpbGl0YXRpb248L2tl

eXdvcmQ+PGtleXdvcmQ+VGFzayBQZXJmb3JtYW5jZSBhbmQgQW5hbHlzaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heS1KdW48L2RhdGU+PC9wdWItZGF0ZXM+PC9k

YXRlcz48aXNibj4wMjcyLTk0OTA8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM1OTc2OTE8L2FjY2Vz

c2lvbi1udW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC41MDE0L2Fq

b3QuMjAxMy4wMDYzMTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2Ut

cHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFu

Z3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2Fya2FtbzwvQXV0aG9yPjxZZWFy

PjIwMTQ8L1llYXI+PFJlY051bT40OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NDk8L3Jl

Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRm

aWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQyMjE2MjIzNiI+NDk8L2tleT48

L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5

cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhcmthbW8sIFQuPC9hdXRob3I+PGF1

dGhvcj5SaXBvbGxlcywgUC48L2F1dGhvcj48YXV0aG9yPlZlcHNhbGFpbmVuLCBILjwvYXV0aG9y

PjxhdXRob3I+QXV0dGksIFQuPC9hdXRob3I+PGF1dGhvcj5TaWx2ZW5ub2luZW4sIEguIE0uPC9h

dXRob3I+PGF1dGhvcj5TYWxsaSwgRS48L2F1dGhvcj48YXV0aG9yPkxhaXRpbmVuLCBTLjwvYXV0

aG9yPjxhdXRob3I+Rm9yc2Jsb20sIEEuPC9hdXRob3I+PGF1dGhvcj5Tb2luaWxhLCBTLjwvYXV0

aG9yPjxhdXRob3I+Um9kcmlndWV6LUZvcm5lbGxzLCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNvZ25pdGl2ZSBCcmFpbiBSZXNlYXJjaCBVbml0LCBD

b2duaXRpdmUgU2NpZW5jZSwgSW5zdGl0dXRlIG9mIEJlaGF2aW91cmFsIFNjaWVuY2VzLCBVbml2

ZXJzaXR5IG9mIEhlbHNpbmtpICwgSGVsc2lua2kgLCBGaW5sYW5kIDsgRmlubmlzaCBDZW50cmUg

b2YgSW50ZXJkaXNjaXBsaW5hcnkgTXVzaWMgUmVzZWFyY2gsIFVuaXZlcnNpdHkgb2YgSGVsc2lu

a2kgLCBIZWxzaW5raSAsIEZpbmxhbmQuJiN4RDtDb2duaXRpb24gYW5kIEJyYWluIFBsYXN0aWNp

dHkgR3JvdXAsIEJlbGx2aXRnZSBCaW9tZWRpY2FsIFJlc2VhcmNoIEluc3RpdHV0ZSAoSURJQkVM

TCksIEwmYXBvcztIb3NwaXRhbGV0IGRlIExsb2JyZWdhdCAsIEJhcmNlbG9uYSAsIFNwYWluIDsg

RGVwYXJ0bWVudCBvZiBCYXNpYyBQc3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9mIEJhcmNlbG9uYSAs

IEJhcmNlbG9uYSAsIFNwYWluLiYjeEQ7Q29nbml0aXZlIEJyYWluIFJlc2VhcmNoIFVuaXQsIENv

Z25pdGl2ZSBTY2llbmNlLCBJbnN0aXR1dGUgb2YgQmVoYXZpb3VyYWwgU2NpZW5jZXMsIFVuaXZl

cnNpdHkgb2YgSGVsc2lua2kgLCBIZWxzaW5raSAsIEZpbmxhbmQuJiN4RDtEZXBhcnRtZW50IG9m

IFJhZGlvbG9neSwgSFVTIE1lZGljYWwgSW1hZ2luZyBDZW50ZXIsIEhlbHNpbmtpIFVuaXZlcnNp

dHkgQ2VudHJhbCBIb3NwaXRhbCwgVW5pdmVyc2l0eSBvZiBIZWxzaW5raSAsIEhlbHNpbmtpICwg

RmlubGFuZC4mI3hEO01paW5hIFNpbGxhbnBhYSBGb3VuZGF0aW9uICwgSGVsc2lua2kgLCBGaW5s

YW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBNdXNpYywgVW5pdmVyc2l0eSBvZiBKeXZhc2t5bGEgLCBK

eXZhc2t5bGEgLCBGaW5sYW5kLiYjeEQ7RGVwYXJ0bWVudCBvZiBOZXVyb2xvZ3ksIFR1cmt1IFVu

aXZlcnNpdHkgSG9zcGl0YWwgLCBUdXJrdSAsIEZpbmxhbmQuJiN4RDtDb2duaXRpb24gYW5kIEJy

YWluIFBsYXN0aWNpdHkgR3JvdXAsIEJlbGx2aXRnZSBCaW9tZWRpY2FsIFJlc2VhcmNoIEluc3Rp

dHV0ZSAoSURJQkVMTCksIEwmYXBvcztIb3NwaXRhbGV0IGRlIExsb2JyZWdhdCAsIEJhcmNlbG9u

YSAsIFNwYWluIDsgRGVwYXJ0bWVudCBvZiBCYXNpYyBQc3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9m

IEJhcmNlbG9uYSAsIEJhcmNlbG9uYSAsIFNwYWluIDsgSW5zdGl0dWNpbyBDYXRhbGFuYSBkZSBS

ZWNlcmNhIGkgRXN0dWRpcyBBdmFuY2F0cyAoSUNSRUEpICwgQmFyY2Vsb25hICwgU3BhaW4uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U3RydWN0dXJhbCBjaGFuZ2VzIGluZHVjZWQgYnkg

ZGFpbHkgbXVzaWMgbGlzdGVuaW5nIGluIHRoZSByZWNvdmVyaW5nIGJyYWluIGFmdGVyIG1pZGRs

ZSBjZXJlYnJhbCBhcnRlcnkgc3Ryb2tlOiBhIHZveGVsLWJhc2VkIG1vcnBob21ldHJ5IHN0dWR5

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkZyb250IEh1bSBOZXVyb3NjaTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+RnJvbnRpZXJzIGluIGh1bWFuIG5ldXJvc2NpZW5jZTwvYWx0LXRpdGxl

PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkZyb250IEh1bSBOZXVyb3NjaTwvZnVs

bC10aXRsZT48YWJici0xPkZyb250aWVycyBpbiBodW1hbiBuZXVyb3NjaWVuY2U8L2FiYnItMT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkZyb250IEh1bSBOZXVyb3Nj

aTwvZnVsbC10aXRsZT48YWJici0xPkZyb250aWVycyBpbiBodW1hbiBuZXVyb3NjaWVuY2U8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yNDU8L3BhZ2VzPjx2b2x1bWU+ODwvdm9sdW1l

PjxlZGl0aW9uPjIwMTQvMDUvMjc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPmVudmlyb25t

ZW50YWwgZW5yaWNobWVudDwva2V5d29yZD48a2V5d29yZD5tYWduZXRpYyByZXNvbmFuY2UgaW1h

Z2luZzwva2V5d29yZD48a2V5d29yZD5tdXNpYzwva2V5d29yZD48a2V5d29yZD5uZXVyb3BsYXN0

aWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+cmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+

c3BlZWNoPC9rZXl3b3JkPjxrZXl3b3JkPnN0cm9rZTwva2V5d29yZD48a2V5d29yZD52b3hlbC1i

YXNlZCBtb3JwaG9tZXRyeTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95

ZWFyPjwvZGF0ZXM+PGlzYm4+MTY2Mi01MTYxPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0ODYwNDY2

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QbWM0MDI5MDIwPC9jdXN0b20y

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4zMzg5L2ZuaHVtLjIwMTQuMDAyNDU8L2VsZWN0

cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUt

ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4AAD==

ADDIN EN.CITE.DATA [18-20].How active patients are depends on many factors including therapy intensity provided, staff culture encouraging activity, and equipment available. There is a huge growth in evidence that hospital design has an impact on patient recovery ADDIN EN.CITE <EndNote><Cite><Author>Ulrich</Author><Year>2008</Year><RecNum>182</RecNum><DisplayText>[21]</DisplayText><record><rec-number>182</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1459682827">182</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Ulrich, R. S.</author><author>Zimring, C.</author><author>Zhu, X.</author><author>DuBose, J.</author><author>Seo, H. B.</author><author>Choi, Y. S.</author><author>Quan, X.</author><author>Joseph, A.</author></authors></contributors><auth-address>College of Architecture, Texas A&amp;M University, College station, TX 77843-3137, USA. rulrich@tamu.edu</auth-address><titles><title>A review of the research literature on evidence-based healthcare design</title><secondary-title>Herd</secondary-title><alt-title>Herd</alt-title></titles><periodical><full-title>Herd</full-title><abbr-1>Herd</abbr-1></periodical><alt-periodical><full-title>Herd</full-title><abbr-1>Herd</abbr-1></alt-periodical><pages>61-125</pages><volume>1</volume><number>3</number><edition>2008/04/01</edition><keywords><keyword>*Environment, Controlled</keyword><keyword>*Evidence-Based Practice</keyword><keyword>*Facility Design and Construction</keyword><keyword>*Health Facility Environment</keyword><keyword>Humans</keyword><keyword>Infection Control</keyword><keyword>Occupational Diseases/prevention &amp; control</keyword><keyword>*Patient Safety</keyword><keyword>*Quality of Health Care</keyword></keywords><dates><year>2008</year><pub-dates><date>Spring</date></pub-dates></dates><isbn>1937-5867 (Print)&#xD;1937-5867</isbn><accession-num>21161908</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[21] but we are unable to find evidence regarding the effect of hospital physical environment on activity levels. The published literature contains strong evidence that single rooms reduce infections and falls, increase privacy and sleep and prevent medication errors in patients ADDIN EN.CITE <EndNote><Cite><Author>Pennington</Author><Year>2013</Year><RecNum>15</RecNum><DisplayText>[22]</DisplayText><record><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="ezw0r5rx7p0sztextfzvzvrvtxdrzewx005v" timestamp="1461733362">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pennington, H.</author><author>Isles, C.</author></authors></contributors><auth-address>University of Aberdeen, Aberdeen, UK.</auth-address><titles><title>Should hospitals provide all patients with single rooms?</title><secondary-title>Bmj</secondary-title><alt-title>BMJ (Clinical research ed.)</alt-title></titles><periodical><full-title>Bmj</full-title><abbr-1>BMJ (Clinical research ed.)</abbr-1></periodical><alt-periodical><full-title>Bmj</full-title><abbr-1>BMJ (Clinical research ed.)</abbr-1></alt-periodical><pages>f5695</pages><volume>347</volume><edition>2013/09/26</edition><keywords><keyword>Cross Infection/prevention &amp; control</keyword><keyword>*Hospital Administration</keyword><keyword>Humans</keyword><keyword>*Patient Preference</keyword><keyword>*Patients&apos; Rooms</keyword><keyword>Privacy</keyword><keyword>Scotland</keyword></keywords><dates><year>2013</year></dates><isbn>0959-535x</isbn><accession-num>24065553</accession-num><urls></urls><electronic-resource-num>10.1136/bmj.f5695</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[22]. However, the reduction in falls is linked to a decline in patient activity as bathrooms are closer PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5ncmF6aW88L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy

PjxSZWNOdW0+MTg8L1JlY051bT48RGlzcGxheVRleHQ+WzIzLTI1XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1w

PSIxNDYxNzMzNTE3Ij4xODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

UGFuZ3JhemlvLCBKLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h

ZGRyZXNzPmpwYW5ncmF6aW9AbmJiai5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5S

b29tIHdpdGggYSB2aWV3LiBMb29raW5nIGF0IHRoZSBmdXR1cmUgb2YgcGF0aWVudCByb29tIGRl

c2lnbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5IZWFsdGggRmFjaWwgTWFuYWdlPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5IZWFsdGggZmFjaWxpdGllcyBtYW5hZ2VtZW50PC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SGVhbHRoIEZhY2lsIE1hbmFnZTwv

ZnVsbC10aXRsZT48YWJici0xPkhlYWx0aCBmYWNpbGl0aWVzIG1hbmFnZW1lbnQ8L2FiYnItMT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkhlYWx0aCBGYWNpbCBNYW5h

Z2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5IZWFsdGggZmFjaWxpdGllcyBtYW5hZ2VtZW50PC9hYmJy

LTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzAtMjwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1l

PjxudW1iZXI+MTI8L251bWJlcj48ZWRpdGlvbj4yMDA0LzAxLzA5PC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5FZmZpY2llbmN5LCBPcmdhbml6YXRpb25hbDwva2V5d29yZD48a2V5d29yZD5I

ZWFsdGggRmFjaWxpdHkgRW52aXJvbm1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgQ29z

dHM8L2tleXdvcmQ+PGtleXdvcmQ+Kkhvc3BpdGFsIERlc2lnbiBhbmQgQ29uc3RydWN0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW50ZXJpb3IgRGVzaWdu

IGFuZCBGdXJuaXNoaW5nczwva2V5d29yZD48a2V5d29yZD5QYXRpZW50IFNhdGlzZmFjdGlvbjwv

a2V5d29yZD48a2V5d29yZD5QYXRpZW50cyZhcG9zOyBSb29tcy8qb3JnYW5pemF0aW9uICZhbXA7

IGFkbWluaXN0cmF0aW9uL3N0YW5kYXJkczwva2V5d29yZD48a2V5d29yZD5Vbml0ZWQgU3RhdGVz

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDM8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wODk5LTYyMTAgKFByaW50

KSYjeEQ7MDg5OS02MjEwPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0NzEwNjg3PC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRh

dGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

Q2l0ZT48QXV0aG9yPkNsYW5jeTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJlY051bT4xOTwv

UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSJlencwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYi

IHRpbWVzdGFtcD0iMTQ2MTczMzU4MSI+MTk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y

cz48YXV0aG9yPkNsYW5jeSwgQy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5BZ2VuY3kgZm9yIEhlYWx0aGNhcmUgUmVzZWFyY2ggYW5kIFF1YWxpdHks

IFJvY2t2aWxsZSwgTWFyeWxhbmQsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5E

ZXNpZ25pbmcgZm9yIHNhZmV0eTogZXZpZGVuY2UtYmFzZWQgZGVzaWduIGFuZCBob3NwaXRhbHM8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBNZWQgUXVhbDwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+QW1lcmljYW4gam91cm5hbCBvZiBtZWRpY2FsIHF1YWxpdHkgOiB0aGUgb2ZmaWNp

YWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gQ29sbGVnZSBvZiBNZWRpY2FsIFF1YWxpdHk8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbSBKIE1lZCBRdWFsPC9m

dWxsLXRpdGxlPjxhYmJyLTE+QW1lcmljYW4gam91cm5hbCBvZiBtZWRpY2FsIHF1YWxpdHkgOiB0

aGUgb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gQ29sbGVnZSBvZiBNZWRpY2FsIFF1

YWxpdHk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFt

IEogTWVkIFF1YWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbWVyaWNhbiBqb3VybmFsIG9mIG1lZGlj

YWwgcXVhbGl0eSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBDb2xsZWdl

IG9mIE1lZGljYWwgUXVhbGl0eTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY2LTk8

L3BhZ2VzPjx2b2x1bWU+MjM8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRpdGlvbj4yMDA4

LzAxLzEyPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qRXZpZGVuY2UtQmFzZWQgTWVkaWNp

bmU8L2tleXdvcmQ+PGtleXdvcmQ+Kkhvc3BpdGFsIERlc2lnbiBhbmQgQ29uc3RydWN0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qU2FmZXR5IE1hbmFnZW1l

bnQ8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuLUZlYjwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNjItODYwNiAoUHJpbnQpJiN4RDsxMDYyLTg2MDY8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTgxODc1OTM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTc3LzEwNjI4NjA2MDczMTEwMzQ8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxD

aXRlPjxBdXRob3I+RGVzaWduPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVjTnVtPjQxPC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj40MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIg

dGltZXN0YW1wPSIxNDYxNzQzMjA3Ij40MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJXZWIgUGFnZSI+MTI8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Xb3JsZCBIZWFsdGggRGVzaWduPC9hdXRob3I+PC9hdXRob3JzPjxzZWNvbmRhcnktYXV0aG9y

cz48YXV0aG9yPkthdGUgRmFpcmhhbGwsIEJTYyAoSG9ucyksIE1TYzsgTGF1cmEgQmFjaGUsIEJT

YyAoSG9ucyksIE1TYywgTVBoaWw7IFBldGVyIERvZGQsIE1CQSwgTUFQTTsgUGF0cmljaWEgWW91

bmc8L2F1dGhvcj48L3NlY29uZGFyeS1hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRp

dGxlPlBhdGllbnQgU2FmZXR5OiBTaW5nbGUtYmVkIHZlcnN1cyBtdWx0aS1iZWQgaG9zcGl0YWwg

cm9vbXM8L3RpdGxlPjwvdGl0bGVzPjx2b2x1bWU+MjAxNjwvdm9sdW1lPjxkYXRlcz48eWVhcj4y

MDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cud29y

bGRoZWFsdGhkZXNpZ24uY29tL1BhdGllbnQtU2FmZXR5LVNpbmdsZS1iZWQtdmVyc3VzLW11bHRp

LWJlZC1ob3NwaXRhbC1yb29tcy5hc3B4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVj

b3JkPjwvQ2l0ZT48L0VuZE5vdGU+AAA=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5ncmF6aW88L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy

PjxSZWNOdW0+MTg8L1JlY051bT48RGlzcGxheVRleHQ+WzIzLTI1XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1w

PSIxNDYxNzMzNTE3Ij4xODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

UGFuZ3JhemlvLCBKLiBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h

ZGRyZXNzPmpwYW5ncmF6aW9AbmJiai5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5S

b29tIHdpdGggYSB2aWV3LiBMb29raW5nIGF0IHRoZSBmdXR1cmUgb2YgcGF0aWVudCByb29tIGRl

c2lnbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5IZWFsdGggRmFjaWwgTWFuYWdlPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5IZWFsdGggZmFjaWxpdGllcyBtYW5hZ2VtZW50PC9hbHQtdGl0

bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SGVhbHRoIEZhY2lsIE1hbmFnZTwv

ZnVsbC10aXRsZT48YWJici0xPkhlYWx0aCBmYWNpbGl0aWVzIG1hbmFnZW1lbnQ8L2FiYnItMT48

L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkhlYWx0aCBGYWNpbCBNYW5h

Z2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5IZWFsdGggZmFjaWxpdGllcyBtYW5hZ2VtZW50PC9hYmJy

LTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzAtMjwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1l

PjxudW1iZXI+MTI8L251bWJlcj48ZWRpdGlvbj4yMDA0LzAxLzA5PC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5FZmZpY2llbmN5LCBPcmdhbml6YXRpb25hbDwva2V5d29yZD48a2V5d29yZD5I

ZWFsdGggRmFjaWxpdHkgRW52aXJvbm1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgQ29z

dHM8L2tleXdvcmQ+PGtleXdvcmQ+Kkhvc3BpdGFsIERlc2lnbiBhbmQgQ29uc3RydWN0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW50ZXJpb3IgRGVzaWdu

IGFuZCBGdXJuaXNoaW5nczwva2V5d29yZD48a2V5d29yZD5QYXRpZW50IFNhdGlzZmFjdGlvbjwv

a2V5d29yZD48a2V5d29yZD5QYXRpZW50cyZhcG9zOyBSb29tcy8qb3JnYW5pemF0aW9uICZhbXA7

IGFkbWluaXN0cmF0aW9uL3N0YW5kYXJkczwva2V5d29yZD48a2V5d29yZD5Vbml0ZWQgU3RhdGVz

PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDM8L3llYXI+PHB1Yi1kYXRlcz48

ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wODk5LTYyMTAgKFByaW50

KSYjeEQ7MDg5OS02MjEwPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0NzEwNjg3PC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRh

dGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48

Q2l0ZT48QXV0aG9yPkNsYW5jeTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJlY051bT4xOTwv

UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48

a2V5IGFwcD0iRU4iIGRiLWlkPSJlencwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYi

IHRpbWVzdGFtcD0iMTQ2MTczMzU4MSI+MTk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg

bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y

cz48YXV0aG9yPkNsYW5jeSwgQy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5BZ2VuY3kgZm9yIEhlYWx0aGNhcmUgUmVzZWFyY2ggYW5kIFF1YWxpdHks

IFJvY2t2aWxsZSwgTWFyeWxhbmQsIFVTQS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5E

ZXNpZ25pbmcgZm9yIHNhZmV0eTogZXZpZGVuY2UtYmFzZWQgZGVzaWduIGFuZCBob3NwaXRhbHM8

L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW0gSiBNZWQgUXVhbDwvc2Vjb25kYXJ5LXRpdGxlPjxh

bHQtdGl0bGU+QW1lcmljYW4gam91cm5hbCBvZiBtZWRpY2FsIHF1YWxpdHkgOiB0aGUgb2ZmaWNp

YWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gQ29sbGVnZSBvZiBNZWRpY2FsIFF1YWxpdHk8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbSBKIE1lZCBRdWFsPC9m

dWxsLXRpdGxlPjxhYmJyLTE+QW1lcmljYW4gam91cm5hbCBvZiBtZWRpY2FsIHF1YWxpdHkgOiB0

aGUgb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgQW1lcmljYW4gQ29sbGVnZSBvZiBNZWRpY2FsIFF1

YWxpdHk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFt

IEogTWVkIFF1YWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BbWVyaWNhbiBqb3VybmFsIG9mIG1lZGlj

YWwgcXVhbGl0eSA6IHRoZSBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBBbWVyaWNhbiBDb2xsZWdl

IG9mIE1lZGljYWwgUXVhbGl0eTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY2LTk8

L3BhZ2VzPjx2b2x1bWU+MjM8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRpdGlvbj4yMDA4

LzAxLzEyPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qRXZpZGVuY2UtQmFzZWQgTWVkaWNp

bmU8L2tleXdvcmQ+PGtleXdvcmQ+Kkhvc3BpdGFsIERlc2lnbiBhbmQgQ29uc3RydWN0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qU2FmZXR5IE1hbmFnZW1l

bnQ8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SmFuLUZlYjwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNjItODYwNiAoUHJpbnQpJiN4RDsxMDYyLTg2MDY8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTgxODc1OTM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxl

bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTc3LzEwNjI4NjA2MDczMTEwMzQ8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxD

aXRlPjxBdXRob3I+RGVzaWduPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVjTnVtPjQxPC9S

ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj40MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr

ZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIg

dGltZXN0YW1wPSIxNDYxNzQzMjA3Ij40MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBu

YW1lPSJXZWIgUGFnZSI+MTI8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Xb3JsZCBIZWFsdGggRGVzaWduPC9hdXRob3I+PC9hdXRob3JzPjxzZWNvbmRhcnktYXV0aG9y

cz48YXV0aG9yPkthdGUgRmFpcmhhbGwsIEJTYyAoSG9ucyksIE1TYzsgTGF1cmEgQmFjaGUsIEJT

YyAoSG9ucyksIE1TYywgTVBoaWw7IFBldGVyIERvZGQsIE1CQSwgTUFQTTsgUGF0cmljaWEgWW91

bmc8L2F1dGhvcj48L3NlY29uZGFyeS1hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRp

dGxlPlBhdGllbnQgU2FmZXR5OiBTaW5nbGUtYmVkIHZlcnN1cyBtdWx0aS1iZWQgaG9zcGl0YWwg

cm9vbXM8L3RpdGxlPjwvdGl0bGVzPjx2b2x1bWU+MjAxNjwvdm9sdW1lPjxkYXRlcz48eWVhcj4y

MDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cud29y

bGRoZWFsdGhkZXNpZ24uY29tL1BhdGllbnQtU2FmZXR5LVNpbmdsZS1iZWQtdmVyc3VzLW11bHRp

LWJlZC1ob3NwaXRhbC1yb29tcy5hc3B4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVj

b3JkPjwvQ2l0ZT48L0VuZE5vdGU+AAA=

ADDIN EN.CITE.DATA [23-25] and this raises concerns that single rooms may reduce physical, social and cognitive activity levels in patients. Bed rest is known to not be an effective treatment for most conditions ADDIN EN.CITE <EndNote><Cite><Author>Allen</Author><Year>1999</Year><RecNum>17</RecNum><DisplayText>[26]</DisplayText><record><rec-number>17</rec-number><foreign-keys><key app="EN" db-id="ezw0r5rx7p0sztextfzvzvrvtxdrzewx005v" timestamp="1461733439">17</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Allen, C.</author><author>Glasziou, P.</author><author>Del Mar, C.</author></authors></contributors><auth-address>Centre for General Practice, Graduate School of Medicine, University of Queensland, Australia.</auth-address><titles><title>Bed rest: a potentially harmful treatment needing more careful evaluation</title><secondary-title>Lancet</secondary-title><alt-title>Lancet (London, England)</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet (London, England)</abbr-1></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet (London, England)</abbr-1></alt-periodical><pages>1229-33</pages><volume>354</volume><number>9186</number><edition>1999/10/16</edition><keywords><keyword>Bed Rest/*adverse effects</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Pregnancy</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>1999</year><pub-dates><date>Oct 9</date></pub-dates></dates><isbn>0140-6736 (Print)&#xD;0140-6736</isbn><accession-num>10520630</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[26]. Communal areas and outdoor spaces also play an important role in activity levels for patients in hospital. The presence of communal and outdoor areas that stimulate patients, families and staff to explore outside their room may optimise activity levels and mental wellbeing PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccm93YWxsPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48

UmVjTnVtPjE3MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjEsIDI3XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xNzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFt

cD0iMTQ1ODE3NjkwNiI+MTcxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Ccm93YWxsLCBNLjwvYXV0aG9yPjxhdXRob3I+S29pbmJlcmcsIEkuPC9hdXRob3I+PGF1dGhv

cj5GYWxrLCBILjwvYXV0aG9yPjxhdXRob3I+V2lqaywgSC48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBOdXJzaW5nLCBEZXBhcnRtZW50

IG9mIE5ldXJvYmlvbG9neSwgQ2FyZSBTY2llbmNlcyBhbmQgU29jaWV0eSwgS2Fyb2xpbnNrYSBJ

bnN0aXR1dGUsIFN0b2NraG9sbSwgU3dlZGVuLiBtYXJpYS5icm92YWxsQGtpLnNlPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+UGF0aWVudHMmYXBvczsgZXhwZXJpZW5jZSBvZiBpbXBvcnRh

bnQgZmFjdG9ycyBpbiB0aGUgaGVhbHRoY2FyZSBlbnZpcm9ubWVudCBpbiBvbmNvbG9neSBjYXJl

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkludCBKIFF1YWwgU3R1ZCBIZWFsdGggV2VsbC1iZWlu

Zzwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIHF1

YWxpdGF0aXZlIHN0dWRpZXMgb24gaGVhbHRoIGFuZCB3ZWxsLWJlaW5nPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50IEogUXVhbCBTdHVkIEhlYWx0aCBXZWxs

LWJlaW5nPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIHF1YWxp

dGF0aXZlIHN0dWRpZXMgb24gaGVhbHRoIGFuZCB3ZWxsLWJlaW5nPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5JbnQgSiBRdWFsIFN0dWQgSGVhbHRoIFdl

bGwtYmVpbmc8L2Z1bGwtdGl0bGU+PGFiYnItMT5JbnRlcm5hdGlvbmFsIGpvdXJuYWwgb2YgcXVh

bGl0YXRpdmUgc3R1ZGllcyBvbiBoZWFsdGggYW5kIHdlbGwtYmVpbmc8L2FiYnItMT48L2FsdC1w

ZXJpb2RpY2FsPjxwYWdlcz4yMDg3MDwvcGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PGVkaXRpb24+

MjAxMy8wOC8wOTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtl

eXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BaXIgUG9sbHV0aW9uLCBJbmRvb3I8L2tleXdv

cmQ+PGtleXdvcmQ+RW1waXJpY2FsIFJlc2VhcmNoPC9rZXl3b3JkPjxrZXl3b3JkPkVudmlyb25t

ZW50PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2N1cyBHcm91

cHM8L2tleXdvcmQ+PGtleXdvcmQ+Rm9vZC9zdGFuZGFyZHM8L2tleXdvcmQ+PGtleXdvcmQ+Kkhl

YWx0aCBTZXJ2aWNlcyBOZWVkcyBhbmQgRGVtYW5kPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwv

a2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPk9uY29sb2d5IFNlcnZpY2UsIEhvc3BpdGFsLypzdGFuZGFyZHM8L2tleXdv

cmQ+PGtleXdvcmQ+UGF0aWVudC1DZW50ZXJlZCBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPlBhdGll

bnRzLypwc3ljaG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBzeWNob2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+UXVhbGl0YXRpdmUgUmVzZWFyY2g8L2tleXdvcmQ+PGtleXdvcmQ+VGFzdGU8L2tleXdv

cmQ+PGtleXdvcmQ+UGF0aWVudHMmYXBvczsgZXhwZXJpZW5jZTwva2V5d29yZD48a2V5d29yZD5v

bmNvbG9naWNhbCBjYXJlPC9rZXl3b3JkPjxrZXl3b3JkPnBhdGllbnQgcGVyc3BlY3RpdmU8L2tl

eXdvcmQ+PGtleXdvcmQ+cGVyc29uLWNlbnRyZWQgY2FyZTwva2V5d29yZD48a2V5d29yZD5waHlz

aWNhbCBhbmQgcHN5Y2hvc29jaWFsIGZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxpc2JuPjE3NDgtMjYyMzwvaXNibj48YWNjZXNzaW9u

LW51bT4yMzkyNDYwNDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzcz

NzQzODwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMzQwMi9xaHcudjhpMC4y

MDg3MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5O

TE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5VbHJpY2g8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

PjxSZWNOdW0+MTgyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xODI8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5

ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQ1OTY4MjgyNyI+MTgyPC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5VbHJpY2gsIFIuIFMuPC9hdXRob3I+PGF1dGhvcj5a

aW1yaW5nLCBDLjwvYXV0aG9yPjxhdXRob3I+Wmh1LCBYLjwvYXV0aG9yPjxhdXRob3I+RHVCb3Nl

LCBKLjwvYXV0aG9yPjxhdXRob3I+U2VvLCBILiBCLjwvYXV0aG9yPjxhdXRob3I+Q2hvaSwgWS4g

Uy48L2F1dGhvcj48YXV0aG9yPlF1YW4sIFguPC9hdXRob3I+PGF1dGhvcj5Kb3NlcGgsIEEuPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q29sbGVnZSBvZiBB

cmNoaXRlY3R1cmUsIFRleGFzIEEmYW1wO00gVW5pdmVyc2l0eSwgQ29sbGVnZSBzdGF0aW9uLCBU

WCA3Nzg0My0zMTM3LCBVU0EuIHJ1bHJpY2hAdGFtdS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5BIHJldmlldyBvZiB0aGUgcmVzZWFyY2ggbGl0ZXJhdHVyZSBvbiBldmlkZW5jZS1i

YXNlZCBoZWFsdGhjYXJlIGRlc2lnbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5IZXJkPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5IZXJkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+SGVyZDwvZnVsbC10aXRsZT48YWJici0xPkhlcmQ8L2FiYnItMT48L3Bl

cmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkhlcmQ8L2Z1bGwtdGl0bGU+PGFi

YnItMT5IZXJkPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjEtMTI1PC9wYWdlcz48

dm9sdW1lPjE8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDA4LzA0LzAxPC9l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qRW52aXJvbm1lbnQsIENvbnRyb2xsZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+KkV2aWRlbmNlLUJhc2VkIFByYWN0aWNlPC9rZXl3b3JkPjxrZXl3b3JkPipG

YWNpbGl0eSBEZXNpZ24gYW5kIENvbnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD4qSGVhbHRo

IEZhY2lsaXR5IEVudmlyb25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbmZlY3Rpb24gQ29udHJvbDwva2V5d29yZD48a2V5d29yZD5PY2N1cGF0aW9uYWwg

RGlzZWFzZXMvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPipQYXRp

ZW50IFNhZmV0eTwva2V5d29yZD48a2V5d29yZD4qUXVhbGl0eSBvZiBIZWFsdGggQ2FyZTwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+

U3ByaW5nPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTkzNy01ODY3IChQcmludCkm

I3hEOzE5MzctNTg2NzwvaXNibj48YWNjZXNzaW9uLW51bT4yMTE2MTkwODwvYWNjZXNzaW9uLW51

bT48dXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRh

YmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgAAAA==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccm93YWxsPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48

UmVjTnVtPjE3MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjEsIDI3XTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xNzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i

RU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFt

cD0iMTQ1ODE3NjkwNiI+MTcxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv

dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv

cj5Ccm93YWxsLCBNLjwvYXV0aG9yPjxhdXRob3I+S29pbmJlcmcsIEkuPC9hdXRob3I+PGF1dGhv

cj5GYWxrLCBILjwvYXV0aG9yPjxhdXRob3I+V2lqaywgSC48L2F1dGhvcj48L2F1dGhvcnM+PC9j

b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBOdXJzaW5nLCBEZXBhcnRtZW50

IG9mIE5ldXJvYmlvbG9neSwgQ2FyZSBTY2llbmNlcyBhbmQgU29jaWV0eSwgS2Fyb2xpbnNrYSBJ

bnN0aXR1dGUsIFN0b2NraG9sbSwgU3dlZGVuLiBtYXJpYS5icm92YWxsQGtpLnNlPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+UGF0aWVudHMmYXBvczsgZXhwZXJpZW5jZSBvZiBpbXBvcnRh

bnQgZmFjdG9ycyBpbiB0aGUgaGVhbHRoY2FyZSBlbnZpcm9ubWVudCBpbiBvbmNvbG9neSBjYXJl

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkludCBKIFF1YWwgU3R1ZCBIZWFsdGggV2VsbC1iZWlu

Zzwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIHF1

YWxpdGF0aXZlIHN0dWRpZXMgb24gaGVhbHRoIGFuZCB3ZWxsLWJlaW5nPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50IEogUXVhbCBTdHVkIEhlYWx0aCBXZWxs

LWJlaW5nPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIHF1YWxp

dGF0aXZlIHN0dWRpZXMgb24gaGVhbHRoIGFuZCB3ZWxsLWJlaW5nPC9hYmJyLTE+PC9wZXJpb2Rp

Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5JbnQgSiBRdWFsIFN0dWQgSGVhbHRoIFdl

bGwtYmVpbmc8L2Z1bGwtdGl0bGU+PGFiYnItMT5JbnRlcm5hdGlvbmFsIGpvdXJuYWwgb2YgcXVh

bGl0YXRpdmUgc3R1ZGllcyBvbiBoZWFsdGggYW5kIHdlbGwtYmVpbmc8L2FiYnItMT48L2FsdC1w

ZXJpb2RpY2FsPjxwYWdlcz4yMDg3MDwvcGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PGVkaXRpb24+

MjAxMy8wOC8wOTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtl

eXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BaXIgUG9sbHV0aW9uLCBJbmRvb3I8L2tleXdv

cmQ+PGtleXdvcmQ+RW1waXJpY2FsIFJlc2VhcmNoPC9rZXl3b3JkPjxrZXl3b3JkPkVudmlyb25t

ZW50PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2N1cyBHcm91

cHM8L2tleXdvcmQ+PGtleXdvcmQ+Rm9vZC9zdGFuZGFyZHM8L2tleXdvcmQ+PGtleXdvcmQ+Kkhl

YWx0aCBTZXJ2aWNlcyBOZWVkcyBhbmQgRGVtYW5kPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwv

a2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPk9uY29sb2d5IFNlcnZpY2UsIEhvc3BpdGFsLypzdGFuZGFyZHM8L2tleXdv

cmQ+PGtleXdvcmQ+UGF0aWVudC1DZW50ZXJlZCBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPlBhdGll

bnRzLypwc3ljaG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBzeWNob2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+UXVhbGl0YXRpdmUgUmVzZWFyY2g8L2tleXdvcmQ+PGtleXdvcmQ+VGFzdGU8L2tleXdv

cmQ+PGtleXdvcmQ+UGF0aWVudHMmYXBvczsgZXhwZXJpZW5jZTwva2V5d29yZD48a2V5d29yZD5v

bmNvbG9naWNhbCBjYXJlPC9rZXl3b3JkPjxrZXl3b3JkPnBhdGllbnQgcGVyc3BlY3RpdmU8L2tl

eXdvcmQ+PGtleXdvcmQ+cGVyc29uLWNlbnRyZWQgY2FyZTwva2V5d29yZD48a2V5d29yZD5waHlz

aWNhbCBhbmQgcHN5Y2hvc29jaWFsIGZhY3RvcnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjxpc2JuPjE3NDgtMjYyMzwvaXNibj48YWNjZXNzaW9u

LW51bT4yMzkyNDYwNDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzcz

NzQzODwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMzQwMi9xaHcudjhpMC4y

MDg3MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5O

TE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl

Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5VbHJpY2g8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFy

PjxSZWNOdW0+MTgyPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xODI8L3JlYy1udW1iZXI+

PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5

ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQ1OTY4MjgyNyI+MTgyPC9rZXk+PC9mb3JlaWdu

LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250

cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5VbHJpY2gsIFIuIFMuPC9hdXRob3I+PGF1dGhvcj5a

aW1yaW5nLCBDLjwvYXV0aG9yPjxhdXRob3I+Wmh1LCBYLjwvYXV0aG9yPjxhdXRob3I+RHVCb3Nl

LCBKLjwvYXV0aG9yPjxhdXRob3I+U2VvLCBILiBCLjwvYXV0aG9yPjxhdXRob3I+Q2hvaSwgWS4g

Uy48L2F1dGhvcj48YXV0aG9yPlF1YW4sIFguPC9hdXRob3I+PGF1dGhvcj5Kb3NlcGgsIEEuPC9h

dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q29sbGVnZSBvZiBB

cmNoaXRlY3R1cmUsIFRleGFzIEEmYW1wO00gVW5pdmVyc2l0eSwgQ29sbGVnZSBzdGF0aW9uLCBU

WCA3Nzg0My0zMTM3LCBVU0EuIHJ1bHJpY2hAdGFtdS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5BIHJldmlldyBvZiB0aGUgcmVzZWFyY2ggbGl0ZXJhdHVyZSBvbiBldmlkZW5jZS1i

YXNlZCBoZWFsdGhjYXJlIGRlc2lnbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5IZXJkPC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5IZXJkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+SGVyZDwvZnVsbC10aXRsZT48YWJici0xPkhlcmQ8L2FiYnItMT48L3Bl

cmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkhlcmQ8L2Z1bGwtdGl0bGU+PGFi

YnItMT5IZXJkPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjEtMTI1PC9wYWdlcz48

dm9sdW1lPjE8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDA4LzA0LzAxPC9l

ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qRW52aXJvbm1lbnQsIENvbnRyb2xsZWQ8L2tleXdv

cmQ+PGtleXdvcmQ+KkV2aWRlbmNlLUJhc2VkIFByYWN0aWNlPC9rZXl3b3JkPjxrZXl3b3JkPipG

YWNpbGl0eSBEZXNpZ24gYW5kIENvbnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD4qSGVhbHRo

IEZhY2lsaXR5IEVudmlyb25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48

a2V5d29yZD5JbmZlY3Rpb24gQ29udHJvbDwva2V5d29yZD48a2V5d29yZD5PY2N1cGF0aW9uYWwg

RGlzZWFzZXMvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPipQYXRp

ZW50IFNhZmV0eTwva2V5d29yZD48a2V5d29yZD4qUXVhbGl0eSBvZiBIZWFsdGggQ2FyZTwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+

U3ByaW5nPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTkzNy01ODY3IChQcmludCkm

I3hEOzE5MzctNTg2NzwvaXNibj48YWNjZXNzaW9uLW51bT4yMTE2MTkwODwvYWNjZXNzaW9uLW51

bT48dXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRh

YmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgAAAA==

ADDIN EN.CITE.DATA [21, 27]. There is a growing body of evidence in healthy populations that factors such as greenspace and performing physical activity outdoors or in a more natural environment can greatly reduce adverse mental health outcomes, cardiovascular disease and mortality PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW1lczwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl

Y051bT4zMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjgsIDI5XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4zMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIx

NDYxNzM0Njc0Ij4zMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SmFt

ZXMsIFAuPC9hdXRob3I+PGF1dGhvcj5CYW5heSwgUi4gRi48L2F1dGhvcj48YXV0aG9yPkhhcnQs

IEouIEUuPC9hdXRob3I+PGF1dGhvcj5MYWRlbiwgRi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSGFydmFy

ZCBULkguIENoYW4gU2Nob29sIG9mIFB1YmxpYyBIZWFsdGggRGVwYXJ0bWVudCBvZiBFbnZpcm9u

bWVudGFsIEhlYWx0aCwgSGFydmFyZCBULkguIENoYW4gU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgg

NDAxIFBhcmsgRHIgMyBGbG9vciBXZXN0IEJvc3RvbiwgTUEgMDIyMTUuJiN4RDtEZXBhcnRtZW50

IG9mIEVudmlyb25tZW50YWwgSGVhbHRoLCBIYXJ2YXJkIFQuSC4gQ2hhbiBTY2hvb2wgb2YgUHVi

bGljIEhlYWx0aCA0MDEgUGFyayBEciAzIEZsb29yIFdlc3QgQm9zdG9uLCBNQSAwMjIxNS4mI3hE

O0NoYW5uaW5nIERpdmlzaW9uIG9mIE5ldHdvcmsgTWVkaWNpbmUsIERlcGFydG1lbnQgb2YgTWVk

aWNpbmUsIEJyaWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCBhbmQgSGFydmFyZCBNZWRp

Y2FsIFNjaG9vbCBEZXBhcnRtZW50IG9mIEVudmlyb25tZW50YWwgSGVhbHRoLCBIYXJ2YXJkIFQu

SC4gQ2hhbiBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCA0MDEgUGFyayBEciAzIEZsb29yIFdlc3Qg

Qm9zdG9uLCBNQSAwMjIxNS4mI3hEO0RlcGFydG1lbnQgb2YgRW52aXJvbm1lbnRhbCBIZWFsdGgs

IEhhcnZhcmQgVC5ILiBDaGFuIFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoIERlcGFydG1lbnQgb2Yg

RXBpZGVtaW9sb2d5LCBIYXJ2YXJkIFQuSC4gQ2hhbiBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCBD

aGFubmluZyBEaXZpc2lvbiBvZiBOZXR3b3JrIE1lZGljaW5lLCBEZXBhcnRtZW50IG9mIE1lZGlj

aW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwgYW5kIEhhcnZhcmQgTWVkaWNh

bCBTY2hvb2wgNDAxIFBhcmsgRHIgMyBGbG9vciBXZXN0IEJvc3RvbiwgTUEgMDIyMTUuPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBSZXZpZXcgb2YgdGhlIEhlYWx0aCBCZW5lZml0cyBv

ZiBHcmVlbm5lc3M8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q3VyciBFcGlkZW1pb2wgUmVwPC9z

ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DdXJyZW50IGVwaWRlbWlvbG9neSByZXBvcnRzPC9h

bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3VyciBFcGlkZW1pb2wg

UmVwPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q3VycmVudCBlcGlkZW1pb2xvZ3kgcmVwb3J0czwvYWJi

ci0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3VyciBFcGlkZW1p

b2wgUmVwPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q3VycmVudCBlcGlkZW1pb2xvZ3kgcmVwb3J0czwv

YWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEzMS0xNDI8L3BhZ2VzPjx2b2x1bWU+Mjwv

dm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMTUvMDcvMTg8L2VkaXRpb24+PGRh

dGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4yMTk2LTI5OTUgKFByaW50KTwvaXNibj48YWNjZXNzaW9uLW51bT4y

NjE4NTc0NTwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+UG1jNDUwMDE5NDwv

Y3VzdG9tMj48Y3VzdG9tNj5OaWhtczY4ODgwMzwvY3VzdG9tNj48ZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+MTAuMTAwNy9zNDA0NzEtMDE1LTAwNDMtNzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+RW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj4mcXVv

dDtNaW5nJnF1b3Q7IEt1bzwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4xPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4xPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0icmVzeDlhd3h0djUwMjdlOXdzZHYwYXYyNTl2ZHdkd3dwczk5IiB0aW1l

c3RhbXA9IjE0NjIwNzIwMTEiPjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPiZxdW90O01pbmcmcXVvdDsgS3VvLCBGcmFuY2VzPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPk5hdHVyZS1kZWZpY2l0IGRpc29yZGVyOiBFdmlkZW5j

ZSwgZG9zYWdlIGFuZCB0cmVhdG1lbnQ8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBv

ZiBQb2xpY3kgUmVzZWFyY2ggaW4gVG91cmlzbSwgbGVpc3VyZSBhbmQgRXZlbnRzPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBQb2xp

Y3kgUmVzZWFyY2ggaW4gVG91cmlzbSwgbGVpc3VyZSBhbmQgRXZlbnRzPC9mdWxsLXRpdGxlPjwv

cGVyaW9kaWNhbD48cGFnZXM+MTcyLTg2PC9wYWdlcz48dm9sdW1lPjU8L3ZvbHVtZT48ZGF0ZXM+

PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW1lczwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl

Y051bT4zMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjgsIDI5XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4zMzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIx

NDYxNzM0Njc0Ij4zMzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SmFt

ZXMsIFAuPC9hdXRob3I+PGF1dGhvcj5CYW5heSwgUi4gRi48L2F1dGhvcj48YXV0aG9yPkhhcnQs

IEouIEUuPC9hdXRob3I+PGF1dGhvcj5MYWRlbiwgRi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250

cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEVwaWRlbWlvbG9neSwgSGFydmFy

ZCBULkguIENoYW4gU2Nob29sIG9mIFB1YmxpYyBIZWFsdGggRGVwYXJ0bWVudCBvZiBFbnZpcm9u

bWVudGFsIEhlYWx0aCwgSGFydmFyZCBULkguIENoYW4gU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgg

NDAxIFBhcmsgRHIgMyBGbG9vciBXZXN0IEJvc3RvbiwgTUEgMDIyMTUuJiN4RDtEZXBhcnRtZW50

IG9mIEVudmlyb25tZW50YWwgSGVhbHRoLCBIYXJ2YXJkIFQuSC4gQ2hhbiBTY2hvb2wgb2YgUHVi

bGljIEhlYWx0aCA0MDEgUGFyayBEciAzIEZsb29yIFdlc3QgQm9zdG9uLCBNQSAwMjIxNS4mI3hE

O0NoYW5uaW5nIERpdmlzaW9uIG9mIE5ldHdvcmsgTWVkaWNpbmUsIERlcGFydG1lbnQgb2YgTWVk

aWNpbmUsIEJyaWdoYW0gYW5kIFdvbWVuJmFwb3M7cyBIb3NwaXRhbCBhbmQgSGFydmFyZCBNZWRp

Y2FsIFNjaG9vbCBEZXBhcnRtZW50IG9mIEVudmlyb25tZW50YWwgSGVhbHRoLCBIYXJ2YXJkIFQu

SC4gQ2hhbiBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCA0MDEgUGFyayBEciAzIEZsb29yIFdlc3Qg

Qm9zdG9uLCBNQSAwMjIxNS4mI3hEO0RlcGFydG1lbnQgb2YgRW52aXJvbm1lbnRhbCBIZWFsdGgs

IEhhcnZhcmQgVC5ILiBDaGFuIFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoIERlcGFydG1lbnQgb2Yg

RXBpZGVtaW9sb2d5LCBIYXJ2YXJkIFQuSC4gQ2hhbiBTY2hvb2wgb2YgUHVibGljIEhlYWx0aCBD

aGFubmluZyBEaXZpc2lvbiBvZiBOZXR3b3JrIE1lZGljaW5lLCBEZXBhcnRtZW50IG9mIE1lZGlj

aW5lLCBCcmlnaGFtIGFuZCBXb21lbiZhcG9zO3MgSG9zcGl0YWwgYW5kIEhhcnZhcmQgTWVkaWNh

bCBTY2hvb2wgNDAxIFBhcmsgRHIgMyBGbG9vciBXZXN0IEJvc3RvbiwgTUEgMDIyMTUuPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBSZXZpZXcgb2YgdGhlIEhlYWx0aCBCZW5lZml0cyBv

ZiBHcmVlbm5lc3M8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q3VyciBFcGlkZW1pb2wgUmVwPC9z

ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DdXJyZW50IGVwaWRlbWlvbG9neSByZXBvcnRzPC9h

bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3VyciBFcGlkZW1pb2wg

UmVwPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q3VycmVudCBlcGlkZW1pb2xvZ3kgcmVwb3J0czwvYWJi

ci0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q3VyciBFcGlkZW1p

b2wgUmVwPC9mdWxsLXRpdGxlPjxhYmJyLTE+Q3VycmVudCBlcGlkZW1pb2xvZ3kgcmVwb3J0czwv

YWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEzMS0xNDI8L3BhZ2VzPjx2b2x1bWU+Mjwv

dm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMTUvMDcvMTg8L2VkaXRpb24+PGRh

dGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0

ZXM+PC9kYXRlcz48aXNibj4yMTk2LTI5OTUgKFByaW50KTwvaXNibj48YWNjZXNzaW9uLW51bT4y

NjE4NTc0NTwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+UG1jNDUwMDE5NDwv

Y3VzdG9tMj48Y3VzdG9tNj5OaWhtczY4ODgwMzwvY3VzdG9tNj48ZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+MTAuMTAwNy9zNDA0NzEtMDE1LTAwNDMtNzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+RW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj4mcXVv

dDtNaW5nJnF1b3Q7IEt1bzwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4xPC9SZWNO

dW0+PHJlY29yZD48cmVjLW51bWJlcj4xPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh

cHA9IkVOIiBkYi1pZD0icmVzeDlhd3h0djUwMjdlOXdzZHYwYXYyNTl2ZHdkd3dwczk5IiB0aW1l

c3RhbXA9IjE0NjIwNzIwMTEiPjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPiZxdW90O01pbmcmcXVvdDsgS3VvLCBGcmFuY2VzPC9hdXRob3I+PC9hdXRob3JzPjwvY29u

dHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPk5hdHVyZS1kZWZpY2l0IGRpc29yZGVyOiBFdmlkZW5j

ZSwgZG9zYWdlIGFuZCB0cmVhdG1lbnQ8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBv

ZiBQb2xpY3kgUmVzZWFyY2ggaW4gVG91cmlzbSwgbGVpc3VyZSBhbmQgRXZlbnRzPC9zZWNvbmRh

cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBQb2xp

Y3kgUmVzZWFyY2ggaW4gVG91cmlzbSwgbGVpc3VyZSBhbmQgRXZlbnRzPC9mdWxsLXRpdGxlPjwv

cGVyaW9kaWNhbD48cGFnZXM+MTcyLTg2PC9wYWdlcz48dm9sdW1lPjU8L3ZvbHVtZT48ZGF0ZXM+

PHllYXI+MjAxMzwveWVhcj48L2RhdGVzPjx1cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgAA

ADDIN EN.CITE.DATA [28, 29]. However, during our literature search we were unable to find evidence of the effect that physical hospital environment including bedroom type, communal and outdoor spaces has on physical, social and cognitive activity, and therefore this requires further exploration. Activity patterns in patients are likely to alter when the Sunshine Coast Health and Hospital Service transitions to a new hospital in 2017. The new hospital will have 16 single (80%) and 2 (20%) double bedrooms in the acute stroke unit and the rehab unit will have 20 single rooms and 14 double bedrooms for their patients. In the current acute stroke unit in Nambour General Hospital there are 8 single bedrooms and 4 double rooms and minimal communal space. The Caloundra Rehab Unit has 5 single rooms, 4 double rooms and 2 x 3 and 2 x 4 multi-bedrooms which indicates that the new hospital will have a higher ratio of single bedrooms. Also, the current rehabilitation unit is at ground level, patients have easy access to a lounge area, outside garden area and kiosk while in the new hospital the rehab unit will be situated at level 5, with outdoor areas at ground level and some communal spaces at ward level. Patient, family and staff activities within these newly designed communal and outdoor areas will be of particular interest given the positive relationship physical, social and cognitive activity has with rehabilitation outcomes. However, how frequently these areas are utilized is unknown and there is no evidence how they may influence patient activity levels. It would therefore be very beneficial to investigate if the change in hospital design with the move from old to new wards has an impact on activity levels in patients. Given the evidence that stroke patients spend the majority of their time alone and inactive in current ward environments, and the known associations between this and poor outcomes, it is imperative that we understand the impact of the forthcoming transition to SCUH on activity levels in patients.The planned transition of Acute Stroke and Rehabilitation Units provides an excellent opportunity to investigate the effects of a change in built environment on physical, social and cognitive activity levels within a hospital setting. This observational study will contribute to current knowledge in regards to how hospital design plays a role in changing patient activity levels when such a transition takes place.The gold standard of observing activity levels in patients is through behavioral mapping PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNrZXk8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS

ZWNOdW0+NjE8L1JlY051bT48RGlzcGxheVRleHQ+WzMwLCAzMV08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0i

MTQyMjE4MDA0NCI+NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1h

Y2tleSwgRi48L2F1dGhvcj48YXV0aG9yPkFkYSwgTC48L2F1dGhvcj48YXV0aG9yPkhlYXJkLCBS

LjwvYXV0aG9yPjxhdXRob3I+QWRhbXMsIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+UGh5c2lvdGhlcmFweSBEZXBhcnRtZW50LCBJbGxhd2FycmEgUmVn

aW9uYWwgSG9zcGl0YWwsIFdvbGxvbmdvbmcsIEF1c3RyYWxpYS48L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5TdHJva2UgcmVoYWJpbGl0YXRpb246IGFyZSBoaWdobHkgc3RydWN0dXJlZCB1

bml0cyBtb3JlIGNvbmR1Y2l2ZSB0byBwaHlzaWNhbCBhY3Rpdml0eSB0aGFuIGxlc3Mgc3RydWN0

dXJlZCB1bml0cz88L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmls

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2lu

ZSBhbmQgcmVoYWJpbGl0YXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BcmNoIFBoeXMgTWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZl

cyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFyY2ggUGh5cyBNZWQgUmVoYWJpbDwv

ZnVsbC10aXRsZT48YWJici0xPkFyY2hpdmVzIG9mIHBoeXNpY2FsIG1lZGljaW5lIGFuZCByZWhh

YmlsaXRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwNjYtNzA8L3BhZ2Vz

Pjx2b2x1bWU+Nzc8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVkaXRpb24+MTk5Ni8xMC8w

MTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2Vk

LCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5DZXJlYnJvdmFzY3VsYXIgRGlzb3JkZXJz

LypyZWhhYmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5GYWNpbGl0eSBEZXNpZ24gYW5kIENv

bnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+Kk1vdG9yIEFjdGl2aXR5PC9rZXl3b3JkPjxrZXl3b3JkPlJlaGFi

aWxpdGF0aW9uIENlbnRlcnMvKm9yZ2FuaXphdGlvbiAmYW1wOyBhZG1pbmlzdHJhdGlvbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+

T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwMy05OTkzIChQcmludCkmI3hE

OzAwMDMtOTk5MzwvaXNibj48YWNjZXNzaW9uLW51bT44ODU3ODg4PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPkJlcm5oYXJkdDwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4xNDwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRp

bWVzdGFtcD0iMTQyMjAxMDA5NyI+MTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkJlcm5oYXJkdCwgSi48L2F1dGhvcj48YXV0aG9yPkRld2V5LCBILjwvYXV0aG9yPjxh

dXRob3I+VGhyaWZ0LCBBLjwvYXV0aG9yPjxhdXRob3I+RG9ubmFuLCBHLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk5hdGlvbmFsIFN0cm9rZSBSZXNlYXJj

aCBJbnN0aXR1dGUsIEF1c3RpbiBIZWFsdGgsIEhlaWRlbGJlcmcgUmVwYXRyaWF0aW9uIEhvc3Bp

dGFsLCBIZWlkZWxiZXJnLCBWaWN0b3JpYSwgQXVzdHJhbGlhLiBKYmVybmhhcmR0QGF1c3Rpbi51

bmltZWxiLmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluYWN0aXZlIGFuZCBh

bG9uZTogcGh5c2ljYWwgYWN0aXZpdHkgd2l0aGluIHRoZSBmaXJzdCAxNCBkYXlzIG9mIGFjdXRl

IHN0cm9rZSB1bml0IGNhcmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxh

dGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwv

ZnVsbC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBqb3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0

aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJv

a2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJj

dWxhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwMDUtOTwvcGFnZXM+PHZv

bHVtZT4zNTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDIvMjg8L2Vk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+

QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5CZWQgUmVzdDwv

a2V5d29yZD48a2V5d29yZD4qRWFybHkgQW1idWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1h

bGU8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+TW90b3IgQWN0aXZpdHk8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2

ZXIgVmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS9kaWFnbm9zaXMvKnJlaGFiaWxp

dGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0OTg4

NTc0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTE2MS8wMS5zdHIuMDAwMDEyMDcyNy40MDc5Mi40MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRl

cj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWNrZXk8L0F1dGhvcj48WWVhcj4xOTk2PC9ZZWFyPjxS

ZWNOdW0+NjE8L1JlY051bT48RGlzcGxheVRleHQ+WzMwLCAzMV08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0i

MTQyMjE4MDA0NCI+NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1h

Y2tleSwgRi48L2F1dGhvcj48YXV0aG9yPkFkYSwgTC48L2F1dGhvcj48YXV0aG9yPkhlYXJkLCBS

LjwvYXV0aG9yPjxhdXRob3I+QWRhbXMsIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+UGh5c2lvdGhlcmFweSBEZXBhcnRtZW50LCBJbGxhd2FycmEgUmVn

aW9uYWwgSG9zcGl0YWwsIFdvbGxvbmdvbmcsIEF1c3RyYWxpYS48L2F1dGgtYWRkcmVzcz48dGl0

bGVzPjx0aXRsZT5TdHJva2UgcmVoYWJpbGl0YXRpb246IGFyZSBoaWdobHkgc3RydWN0dXJlZCB1

bml0cyBtb3JlIGNvbmR1Y2l2ZSB0byBwaHlzaWNhbCBhY3Rpdml0eSB0aGFuIGxlc3Mgc3RydWN0

dXJlZCB1bml0cz88L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmls

PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2lu

ZSBhbmQgcmVoYWJpbGl0YXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5BcmNoIFBoeXMgTWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZl

cyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L3Blcmlv

ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFyY2ggUGh5cyBNZWQgUmVoYWJpbDwv

ZnVsbC10aXRsZT48YWJici0xPkFyY2hpdmVzIG9mIHBoeXNpY2FsIG1lZGljaW5lIGFuZCByZWhh

YmlsaXRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwNjYtNzA8L3BhZ2Vz

Pjx2b2x1bWU+Nzc8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVkaXRpb24+MTk5Ni8xMC8w

MTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2Vk

LCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5DZXJlYnJvdmFzY3VsYXIgRGlzb3JkZXJz

LypyZWhhYmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5GYWNpbGl0eSBEZXNpZ24gYW5kIENv

bnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+Kk1vdG9yIEFjdGl2aXR5PC9rZXl3b3JkPjxrZXl3b3JkPlJlaGFi

aWxpdGF0aW9uIENlbnRlcnMvKm9yZ2FuaXphdGlvbiAmYW1wOyBhZG1pbmlzdHJhdGlvbjwva2V5

d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+

T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwMy05OTkzIChQcmludCkmI3hE

OzAwMDMtOTk5MzwvaXNibj48YWNjZXNzaW9uLW51bT44ODU3ODg4PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48

QXV0aG9yPkJlcm5oYXJkdDwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4xNDwvUmVj

TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5

IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRp

bWVzdGFtcD0iMTQyMjAxMDA5NyI+MTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt

ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48

YXV0aG9yPkJlcm5oYXJkdCwgSi48L2F1dGhvcj48YXV0aG9yPkRld2V5LCBILjwvYXV0aG9yPjxh

dXRob3I+VGhyaWZ0LCBBLjwvYXV0aG9yPjxhdXRob3I+RG9ubmFuLCBHLjwvYXV0aG9yPjwvYXV0

aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk5hdGlvbmFsIFN0cm9rZSBSZXNlYXJj

aCBJbnN0aXR1dGUsIEF1c3RpbiBIZWFsdGgsIEhlaWRlbGJlcmcgUmVwYXRyaWF0aW9uIEhvc3Bp

dGFsLCBIZWlkZWxiZXJnLCBWaWN0b3JpYSwgQXVzdHJhbGlhLiBKYmVybmhhcmR0QGF1c3Rpbi51

bmltZWxiLmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluYWN0aXZlIGFuZCBh

bG9uZTogcGh5c2ljYWwgYWN0aXZpdHkgd2l0aGluIHRoZSBmaXJzdCAxNCBkYXlzIG9mIGFjdXRl

IHN0cm9rZSB1bml0IGNhcmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxh

dGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwv

ZnVsbC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBqb3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0

aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJv

a2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJj

dWxhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwMDUtOTwvcGFnZXM+PHZv

bHVtZT4zNTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDIvMjg8L2Vk

aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+

QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5CZWQgUmVzdDwv

a2V5d29yZD48a2V5d29yZD4qRWFybHkgQW1idWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1h

bGU8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVt

YW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8

L2tleXdvcmQ+PGtleXdvcmQ+TW90b3IgQWN0aXZpdHk8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2

ZXIgVmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS9kaWFnbm9zaXMvKnJlaGFiaWxp

dGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRz

PjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHVi

LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0OTg4

NTc0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

MTAuMTE2MS8wMS5zdHIuMDAwMDEyMDcyNy40MDc5Mi40MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRl

cj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAA

ADDIN EN.CITE.DATA [30, 31]. Behavioral mapping is an observational method, which involves a staff member observing patient activities for 1 minute at 10 minute intervals for a period of 8 to 12 hours a day using a checklist of defined definitions of activities. It provides very rich data for all activity domains but is very costly and analysis is time consuming. Recent innovations in technology have made it possible to monitor physical activity levels and location of patients. This non-invasive, wearable technology has presented a means of objectively evaluating upper and lower limb activity throughout an entire day allowing an insight into the holistic function of a patient not just what is seen in specific time periods ADDIN EN.CITE <EndNote><Cite><Author>Uswatte</Author><Year>2000</Year><RecNum>12</RecNum><DisplayText>[32]</DisplayText><record><rec-number>12</rec-number><foreign-keys><key app="EN" db-id="ezw0r5rx7p0sztextfzvzvrvtxdrzewx005v" timestamp="1461732229">12</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Uswatte, G.</author><author>Miltner, W. H.</author><author>Foo, B.</author><author>Varma, M.</author><author>Moran, S.</author><author>Taub, E.</author></authors></contributors><auth-address>Department of Psychology, University of Alabama at Birmingham, 35294-1170, USA. guswatte@uab.edu</auth-address><titles><title>Objective measurement of functional upper-extremity movement using accelerometer recordings transformed with a threshold filter</title><secondary-title>Stroke</secondary-title><alt-title>Stroke; a journal of cerebral circulation</alt-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><alt-periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></alt-periodical><pages>662-7</pages><volume>31</volume><number>3</number><edition>2000/03/04</edition><keywords><keyword>Adult</keyword><keyword>Arm/*physiopathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>*Movement</keyword><keyword>Outcome Assessment (Health Care)</keyword><keyword>Reference Values</keyword><keyword>Stroke/*physiopathology/*rehabilitation</keyword><keyword>Time Factors</keyword><keyword>Videotape Recording</keyword></keywords><dates><year>2000</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0039-2499 (Print)&#xD;0039-2499</isbn><accession-num>10700501</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[32]. This technology includes accelerometers that resemble wrist-watches which have successfully been used to monitor upper limb PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Vc3dhdHRlPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48

UmVjTnVtPjEyPC9SZWNOdW0+PERpc3BsYXlUZXh0PlszMiwgMzNdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjEyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9

IjE0NjE3MzIyMjkiPjEyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5V

c3dhdHRlLCBHLjwvYXV0aG9yPjxhdXRob3I+TWlsdG5lciwgVy4gSC48L2F1dGhvcj48YXV0aG9y

PkZvbywgQi48L2F1dGhvcj48YXV0aG9yPlZhcm1hLCBNLjwvYXV0aG9yPjxhdXRob3I+TW9yYW4s

IFMuPC9hdXRob3I+PGF1dGhvcj5UYXViLCBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBv

ZiBBbGFiYW1hIGF0IEJpcm1pbmdoYW0sIDM1Mjk0LTExNzAsIFVTQS4gZ3Vzd2F0dGVAdWFiLmVk

dTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk9iamVjdGl2ZSBtZWFzdXJlbWVudCBvZiBm

dW5jdGlvbmFsIHVwcGVyLWV4dHJlbWl0eSBtb3ZlbWVudCB1c2luZyBhY2NlbGVyb21ldGVyIHJl

Y29yZGluZ3MgdHJhbnNmb3JtZWQgd2l0aCBhIHRocmVzaG9sZCBmaWx0ZXI8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEg

am91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVsbC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBq

b3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7

IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGlj

YWw+PHBhZ2VzPjY2Mi03PC9wYWdlcz48dm9sdW1lPjMxPC92b2x1bWU+PG51bWJlcj4zPC9udW1i

ZXI+PGVkaXRpb24+MjAwMC8wMy8wNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8

L2tleXdvcmQ+PGtleXdvcmQ+QXJtLypwaHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPipNb3ZlbWVudDwva2V5d29yZD48a2V5d29yZD5PdXRjb21lIEFzc2Vz

c21lbnQgKEhlYWx0aCBDYXJlKTwva2V5d29yZD48a2V5d29yZD5SZWZlcmVuY2UgVmFsdWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS8qcGh5c2lvcGF0aG9sb2d5LypyZWhhYmlsaXRhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VmlkZW90YXBl

IFJlY29yZGluZzwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0y

NDk5IChQcmludCkmI3hEOzAwMzktMjQ5OTwvaXNibj48YWNjZXNzaW9uLW51bT4xMDcwMDUwMTwv

YWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYXl3YXJkPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjM4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4zODwvcmVjLW51bWJlcj48Zm9y

ZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4

ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYxNzM5OTkwIj4zODwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+SGF5d2FyZCxLYXRocnluIFMuPC9hdXRob3I+PGF1dGhvcj5F

bmcsSmFuaWNlIEouPC9hdXRob3I+PGF1dGhvcj5Cb3lkLExhcmEgQS48L2F1dGhvcj48YXV0aG9y

Pkxha2hhbmksQmltYWw8L2F1dGhvcj48YXV0aG9yPkJlcm5oYXJkdCxKdWxpZTwvYXV0aG9yPjxh

dXRob3I+TGFuZyxDYXRoZXJpbmUgRS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PHRpdGxlcz48dGl0bGU+RXhwbG9yaW5nIHRoZSBSb2xlIG9mIEFjY2VsZXJvbWV0ZXJzIGluIHRo

ZSBNZWFzdXJlbWVudCBvZiBSZWFsIFdvcmxkIFVwcGVyLUxpbWIgVXNlIEFmdGVyIFN0cm9rZTwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5CcmFpbiBJbXBhaXJtZW50PC9zZWNvbmRhcnktdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJhaW4gSW1wYWlybWVudDwvZnVsbC10

aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjE2LTMzPC9wYWdlcz48dm9sdW1lPjE3PC92b2x1bWU+

PG51bWJlcj5TcGVjaWFsIElzc3VlIDAxPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPnN0cm9r

ZSxwYXJlc2lzLGFjY2VsZXJvbWV0cnksd2VhcmFibGUgc2Vuc29ycyxhcm0scmVjb3Zlcnk8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48L2RhdGVzPjxpc2JuPjE4

MzktNTI1MjwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcv

MTAuMTAxNy9CckltcC4yMDE1LjIxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT5kb2k6MTAuMTAxNy9CckltcC4yMDE1LjIxPC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48YWNjZXNzLWRhdGU+MjAxNjwvYWNjZXNzLWRhdGU+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4AAAA=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Vc3dhdHRlPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48

UmVjTnVtPjEyPC9SZWNOdW0+PERpc3BsYXlUZXh0PlszMiwgMzNdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjEyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9

IjE0NjE3MzIyMjkiPjEyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5V

c3dhdHRlLCBHLjwvYXV0aG9yPjxhdXRob3I+TWlsdG5lciwgVy4gSC48L2F1dGhvcj48YXV0aG9y

PkZvbywgQi48L2F1dGhvcj48YXV0aG9yPlZhcm1hLCBNLjwvYXV0aG9yPjxhdXRob3I+TW9yYW4s

IFMuPC9hdXRob3I+PGF1dGhvcj5UYXViLCBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBv

ZiBBbGFiYW1hIGF0IEJpcm1pbmdoYW0sIDM1Mjk0LTExNzAsIFVTQS4gZ3Vzd2F0dGVAdWFiLmVk

dTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk9iamVjdGl2ZSBtZWFzdXJlbWVudCBvZiBm

dW5jdGlvbmFsIHVwcGVyLWV4dHJlbWl0eSBtb3ZlbWVudCB1c2luZyBhY2NlbGVyb21ldGVyIHJl

Y29yZGluZ3MgdHJhbnNmb3JtZWQgd2l0aCBhIHRocmVzaG9sZCBmaWx0ZXI8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEg

am91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVsbC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBq

b3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7

IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGlj

YWw+PHBhZ2VzPjY2Mi03PC9wYWdlcz48dm9sdW1lPjMxPC92b2x1bWU+PG51bWJlcj4zPC9udW1i

ZXI+PGVkaXRpb24+MjAwMC8wMy8wNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8

L2tleXdvcmQ+PGtleXdvcmQ+QXJtLypwaHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r

ZXl3b3JkPjxrZXl3b3JkPipNb3ZlbWVudDwva2V5d29yZD48a2V5d29yZD5PdXRjb21lIEFzc2Vz

c21lbnQgKEhlYWx0aCBDYXJlKTwva2V5d29yZD48a2V5d29yZD5SZWZlcmVuY2UgVmFsdWVzPC9r

ZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS8qcGh5c2lvcGF0aG9sb2d5LypyZWhhYmlsaXRhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VmlkZW90YXBl

IFJlY29yZGluZzwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAwPC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0y

NDk5IChQcmludCkmI3hEOzAwMzktMjQ5OTwvaXNibj48YWNjZXNzaW9uLW51bT4xMDcwMDUwMTwv

YWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYXl3YXJkPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjM4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4zODwvcmVjLW51bWJlcj48Zm9y

ZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImV6dzByNXJ4N3Awc3p0ZXh0Znp2enZydnR4

ZHJ6ZXd4MDA1diIgdGltZXN0YW1wPSIxNDYxNzM5OTkwIj4zODwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+SGF5d2FyZCxLYXRocnluIFMuPC9hdXRob3I+PGF1dGhvcj5F

bmcsSmFuaWNlIEouPC9hdXRob3I+PGF1dGhvcj5Cb3lkLExhcmEgQS48L2F1dGhvcj48YXV0aG9y

Pkxha2hhbmksQmltYWw8L2F1dGhvcj48YXV0aG9yPkJlcm5oYXJkdCxKdWxpZTwvYXV0aG9yPjxh

dXRob3I+TGFuZyxDYXRoZXJpbmUgRS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PHRpdGxlcz48dGl0bGU+RXhwbG9yaW5nIHRoZSBSb2xlIG9mIEFjY2VsZXJvbWV0ZXJzIGluIHRo

ZSBNZWFzdXJlbWVudCBvZiBSZWFsIFdvcmxkIFVwcGVyLUxpbWIgVXNlIEFmdGVyIFN0cm9rZTwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5CcmFpbiBJbXBhaXJtZW50PC9zZWNvbmRhcnktdGl0bGU+

PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QnJhaW4gSW1wYWlybWVudDwvZnVsbC10

aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjE2LTMzPC9wYWdlcz48dm9sdW1lPjE3PC92b2x1bWU+

PG51bWJlcj5TcGVjaWFsIElzc3VlIDAxPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPnN0cm9r

ZSxwYXJlc2lzLGFjY2VsZXJvbWV0cnksd2VhcmFibGUgc2Vuc29ycyxhcm0scmVjb3Zlcnk8L2tl

eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48L2RhdGVzPjxpc2JuPjE4

MzktNTI1MjwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcv

MTAuMTAxNy9CckltcC4yMDE1LjIxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT5kb2k6MTAuMTAxNy9CckltcC4yMDE1LjIxPC9lbGVjdHJvbmljLXJl

c291cmNlLW51bT48YWNjZXNzLWRhdGU+MjAxNjwvYWNjZXNzLWRhdGU+PC9yZWNvcmQ+PC9DaXRl

PjwvRW5kTm90ZT4AAAA=

ADDIN EN.CITE.DATA [32, 33] and lower limb physical activity ADDIN EN.CITE <EndNote><Cite><Author>Bailey</Author><Year>2015</Year><RecNum>30</RecNum><DisplayText>[34]</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="ezw0r5rx7p0sztextfzvzvrvtxdrzewx005v" timestamp="1461734446">30</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bailey, R. R.</author><author>Klaesner, J. W.</author><author>Lang, C. E.</author></authors></contributors><auth-address>Washington University School of Medicine in St Louis, MO, USA.&#xD;Washington University School of Medicine in St Louis, MO, USA langc@wustl.edu.</auth-address><titles><title>Quantifying Real-World Upper-Limb Activity in Nondisabled Adults and Adults With Chronic Stroke</title><secondary-title>Neurorehabil Neural Repair</secondary-title><alt-title>Neurorehabilitation and neural repair</alt-title></titles><periodical><full-title>Neurorehabil Neural Repair</full-title><abbr-1>Neurorehabilitation and neural repair</abbr-1></periodical><alt-periodical><full-title>Neurorehabil Neural Repair</full-title><abbr-1>Neurorehabilitation and neural repair</abbr-1></alt-periodical><pages>969-78</pages><volume>29</volume><number>10</number><edition>2015/04/22</edition><keywords><keyword>accelerometry</keyword><keyword>bilateral upper limb activity</keyword><keyword>motor capability</keyword><keyword>motor performance</keyword><keyword>outcomes assessment</keyword><keyword>real-world activity</keyword></keywords><dates><year>2015</year><pub-dates><date>Nov-Dec</date></pub-dates></dates><isbn>1545-9683</isbn><accession-num>25896988</accession-num><urls></urls><custom2>Pmc4615281</custom2><custom6>Nihms677937</custom6><electronic-resource-num>10.1177/1545968315583720</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[34]. Data can be downloaded to a base station ready for statistical analysis. In combining behavioural mapping and this technology we are able to measure patient activity pre and post transition to a new hospital, investigating the impact of hospital design and at the same time comparing different methods of quantifying activity. This study using new technologies provides an opportunity for the SCHHS to build collaborative links with local universities, setting the district to be a leader in the area and providing baseline data for future research and model of care enhancement. Increasing patient engagement in their care using these new and novel monitoring technologies to provide biofeedback options including timing and location of activity will be a great mechanism to increase patient involvement in their own care. Knowing when, where and how much activity takes place will provide invaluable information to guide the journey to optimal recovery and potentially improve the efficiency of rehabilitation. Embedding the use of this technology into future clinical practice will set the SCHHS as a leader in the area of activity tracking.To control for other factors that will influence patient activity when transitioning to a new hospital we will consider the following:1. Physical environment. This includes bed configuration – total beds (single, double, multi - bed bays)Floor space /patient, Communal areas, Therapy spaces, Outdoor access, Walking distances (bed to- toilet / gym / common area /outdoors).2. Bed and staffing levels will be investigated within the observational period as an increase in staff ratio would impact on activity. Beds serviced in the acute stroke unit will grow from 16 to 20 and in the rehabilitation center from 25 to 30 beds at the new location and staff ratios will be calculated according to patient numbers. 3. Experience of staff will be investigated. The expectation is that the majority of staff from each unit will move to the new unit in the new hospital. We expect that staff change will not be a major factor but the levels of new and old staff will be monitored.4. Familiarity with the new facility. All staff new and old will be unfamiliar with the new hospital. To control for this factor we will allow sufficient time (3 months) for staff to get used to the new facility before the post observation period will start.5. Models of care. The models of care are changing during transition to the new hospital. The main difference will be that the allied health service will go from a weekday service to a 6-day service. As we will monitor activity levels on weekdays and a weekend day during the pre and post transition period we are able to adjust for any changes due to change in model of care. As time spent practicing a task is the key determinant of the level of recovery achieved ADDIN EN.CITE <EndNote><Cite><Author>Kwakkel</Author><Year>2004</Year><RecNum>26</RecNum><DisplayText>[35]</DisplayText><record><rec-number>26</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1422146720">26</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kwakkel, G.</author><author>van Peppen, R.</author><author>Wagenaar, R. C.</author><author>Wood Dauphinee, S.</author><author>Richards, C.</author><author>Ashburn, A.</author><author>Miller, K.</author><author>Lincoln, N.</author><author>Partridge, C.</author><author>Wellwood, I.</author><author>Langhorne, P.</author></authors></contributors><auth-address>Department of Physical Therapy and Research Institute for Fundamental and Clinical Human Movement Sciences, VU University Medical Center, Amsterdam, The Netherlands. g.kwakkel@vumc.nl</auth-address><titles><title>Effects of augmented exercise therapy time after stroke: a meta-analysis</title><secondary-title>Stroke</secondary-title><alt-title>Stroke; a journal of cerebral circulation</alt-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><alt-periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></alt-periodical><pages>2529-39</pages><volume>35</volume><number>11</number><edition>2004/10/09</edition><keywords><keyword>Activities of Daily Living</keyword><keyword>*Exercise Therapy</keyword><keyword>Humans</keyword><keyword>Stroke/*rehabilitation</keyword></keywords><dates><year>2004</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0039-2499</isbn><accession-num>15472114</accession-num><urls></urls><electronic-resource-num>10.1161/01.STR.0000143153.76460.7d</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[35], creating an environment for patients that facilitates activity in all activity domains is of the utmost importance for the Sunshine Coast Hospital and Health Service. This study will investigate if hospital design impacts on patient activity levels and will contribute to evidence for designing future hospitals. By measuring activity levels during pre and post transition it also provides knowledge and skills in patient activity tracking so that future fluctuations may be identified and appropriate responses implemented in a timely manner. Primary AimIn a prospective observational study we will:Determine if the physical hospital environment has an impact on?total,?physical, social and cognitive activity levels using?behavioral mapping and accelerometers in patients recovering in one acute stroke unit (ASU) and one sub-acute rehabilitation unit (RAU) pre and post transition to a newly built hospital wardQuantify body?position,?patient?location and people present with the patient using?behavioral mapping?in patients recovering in one acute stroke unit (ASU) and one sub-acute rehabilitation unit (RAU) pre and post transition to a newly built hospital wardPrimary Hypothesis Activity levels (physical, social and cognitive) and location of patients will decrease with change of physical environment to a single and double bed room ward.Secondary AimsTo compare the role of different methods of measuring physical activity and location: behavioral mapping and accelerometer in inpatient ward environments.Determine baseline data for patient activity levels within the Sunshine Coast University Hospitals Acute Stroke and inpatient Rehabilitation UnitsSecondary Hypothesis1. That accelerometer analysis of gait and upper limb provides equivalent data on physical activity compared to behavioral mapping and are cost effective alternatives.DESIGN:Prospective observational study of activity levels of patients recovering within an acute stroke unit and a sub-acute inpatient rehabilitation unit over 4-months before transition and 4-months after transition to newly built wards. The same four months of the year will be used during pre and post transition to account for any seasonal variability that may exist.The 4-months before transitioning will involve activity monitoring of patients while in a regional acute stroke unit and sub-acute inpatient rehabilitation unit. The second 4 months after transitioning to the new hospital will focus on activity monitoring of an identical number of participants in an acute stroke unit and inpatient rehabilitation unit. SETTING: Observation Period I: The first observation period will occur at the current acute stroke unit in Nambour General Hospital and in the Caloundra Rehabilitation and Assessment Unit (RAU). Participants will receive standard care and treatment of an Acute Stroke Unit and Sub-Acute Inpatient Rehabilitation Unit. ASU: Acute Stroke Unit at Nambour General HospitalBed configuration – total beds (8 x single, 4 x double)Floor space /patient (55.2 sqm and 16 patients ) Common areas (Reception Seating area 6.6sqm, Elevator Seating Area 11.7sqm, Corridor gym seating area 6.4sqm)Therapy spaces ( Therapy Gym floor space 30 sqm)Outdoor access (no access at level, distance from elevators to front of hospital is 114m, to courtyard level 87m, to outdoor undercover area is 42m)Walking distances (bed to ensuite 2.7m -single and 5.6m -double / Pod A (room 1-6) 12.1m and Pod C (room 11-16) 45.4m mean distance to gym / common area /outdoors)RAU:Rehabilitation and Assessment Unit at Caloundra HospitalBed configuration – total beds (5 x single, 4 x double, 2 x 3 bed and 2 x 4 bed bays)Floor space /patient ( m2 and 24 patients )Common areas (one dining room with TV, lounge with TV/audio and puzzles, recreational room with puzzles, fuzzball and painting materials)Therapy spaces (The physiotherapy gym is located an average of 71 meters from rooms on the east wing and 103 meters from rooms on the west. The room is 98 square meters and should not be used when no staff member is in this room. The occupational therapy gym is located an average of 65 meters from rooms on the east wing and 93 meters from rooms on the west wing. The room is 60 square meters and should not be used when no staff member is in this room. The Speech therapy room is located an average of 61 meters from rooms on the east wing and 93 meters from rooms on the west wing. The room is 9 square meters and should not be used when no staff member is in this room)Outdoor access (wheelchair ramp access 22m from ward doorway to main undercover BBQ area it is located an average of 46 meters from rooms on the east wing and 40 meters from rooms on the west wing, in front of hospital is located a sitting area an average of 78 meters from rooms on the east wing and 115 meters from rooms on the west wing, outside room 5/6 located 8m from those rooms, outdoor area close to occupational therapy room is located an average of 65 meters from rooms on the east wing and 93 meters from rooms on the west wing).Walking distances (bed to- toilet distance for rooms on the east wing is 6m and west wing 4m /The physiotherapy gym is located an average of 71 meters from rooms on the east wing and 103 meters from rooms on the west. The occupational therapy gym is located an average of 65 meters from rooms on the east wing and 93 meters from rooms on the west wing. The speech therapy room is located an average of 61 meters from rooms on the east wing and 93 meters from rooms on the west wing/ The Dining room is located an average of 53 meters from rooms on the east wing and 23 meters from rooms on the west wing/ The TV lounge room is located an average of 20 meters from rooms on the east wing and 24 meters from rooms on the west wing/ The recreational room is located an average of 20 meters from rooms on the east wing and 47 meters from rooms on the west wing)Observation Period II:The second observation period will be recorded at the Sunshine Coast University Hospital Acute Stroke Unit and Inpatient Rehabilitation units. Participants will receive the normal standard care and treatment of an Acute Stroke Unit and Sub-Acute Rehabilitation Unit.Sunshine Coast University Hospital Acute Stroke Unit: Bed configuration – open beds (16 x single, 2 x double)Floor space /patient (once access is granted to the site floor space sqm will be calculated and will open with 20 patients)Common areasTherapy spaces ( one gym area located on ward level)Outdoor access (via lifts to ground level)Walking distances (bed to- toilet / gym / common area /outdoorsSunshine Coast University Hospital Acute Rehabilitation unit:Bed configuration – open beds (20 x single, 14 x double)Floor space /patient (once access is granted to the site floor space sqm will be calculated and will open with 30 patients)Common areas (2 lounge and 2 dining rooms)Therapy spaces (one large gym with an outdoor mobility garden, one OT gym, one multi-purpose gym, two large assessment rooms)Outdoor access (at the ward level a outdoor mobility garden and sitting area near the therapy gyms and doors from the 2 lounge and 2 dining rooms lead to a large sitting area)Walking distances (will be calculated once we have access to the site)PATIENTSParticipants in the Acute Stroke Unit:Patients admitted to the acute stroke unit with a diagnosis of stroke will be assessed for eligibility and consecutively enrolled. Every fortnight a new group of up to 5 participants will be recruited for a period of 4 months.Data will be recorded for a period of 3 days (2 weekdays and 1 weekend day) with the Stepwatch and Actigraph Activity Monitors and 2 days (one weekday and one weekend day) with Behavioral Mapping. Participants in the Rehabilitation Unit:To maximize generalizability and comparability of cohorts, enrolment will be stratified across the top three diagnostic groups admitted to public inpatient rehabilitation units in Australian Public and Caloundra Rehabilitation units: stroke, orthopedic fractures and de-conditioning ADDIN EN.CITE <EndNote><Cite><Author>AROC</Author><Year>2015</Year><RecNum>42</RecNum><DisplayText>[36]</DisplayText><record><rec-number>42</rec-number><foreign-keys><key app="EN" db-id="ezw0r5rx7p0sztextfzvzvrvtxdrzewx005v" timestamp="1461743792">42</key></foreign-keys><ref-type name="Report">27</ref-type><contributors><authors><author>AROC</author></authors><secondary-authors><author>Australasian Rehabilitation Outcomes Collaborative</author></secondary-authors></contributors><titles><title>2015 Caloundra Outcomes Benchmark Report</title></titles><pages>1-146</pages><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>[36]. Patients within these groups with the most frequently admitted functional capacity strata as defined by AN-SNAP classes (98) will be included: Stroke 3-204, 3-206, 3-208, 3-209; Orthopaedic fractures 3-227, 3-228, 3-229, and Re-conditioning 3-242, 3-243 and 3-244. Patients within these categories comprise 72% of all, and 90% of stroke/fracture/deconditioning diagnosis related groups (DRG's) admitted to Caloundra Rehabilitation Unit in 2015. This will exclude outliers with uncommon extremes of functional capacity to maximize comparability between the cohorts. Patients admitted to the inpatient Sub-Acute Inpatient Rehabilitation Unit with the above AN-SNAP classes will be assessed for eligibility and consecutively enrolled. Every fortnight a new group of up to 5 participants will be recruited to the study for a period of 4 months. Activity monitoring which will commence between 7 and 14 days after admission, with the weekend day being the first Saturday occurring more than 7 days post-admission and the weekdays being the 2 days either immediately preceding this, or in the situation where this would be less than 7 days post admission, in the week after.Data will be recorded for a period of 3 days (2 weekdays and 1 weekend day) with the Stepwatch and Actigraph Activity Monitors and 2 days (one weekday and one weekend day) with Behavioral Mapping. ELIGIBILIY CRITERIAInclusion criteria:Participants in the ASU:The patient is admitted to the Acute Stroke Unit with the diagnosis of a stroke and enrollment to the study will occur within 7 days after stroke onset. Patient is an adult > 18 years.Patients have an expected stay of more than 2 days.The patient is fit for rehabilitation. The patient requires assistance for basic ADL’s at the time of recruitment.The patient is not deteriorating in the 24 hours before recruitment.The patient or their substitute decision maker is able to provide written informed consent.Pre morbid status for ASU:The patient was walking independently. Participants in the Rehabilitation Unit:The patient is admitted with one of the following AN-SNAP codes; Stroke 3-204, 3-206, 3-208, 3-209; Orthopaedic fractures 3-227, 3-228, 3-229, and Re-conditioning 3-242, 3-243 and 3-244.Patient enrollment will occur within 7 days of admission to the rehab unitPatient is an adult > 18 years and older.The patient or their substitute decision maker is able to provide written informed consent.Patients are in the Rehabilitation Assessment Unit (RAU) during their admission or Acute Inpatient Rehabilitation ward at the Sunshine Coast University Hospital.Patients expected length of stay is of no less than 14 days on admission to the inpatient rehabilitation unit Pre morbid status for Rehabilitation Unit:The patient was walking independently.Exclusion criteria:Participants in the Acute Stroke Unitwith an extensive psychiatric history and who are unable to participate in rehabilitation due to current active medical condition/sParticipants in the Rehabilitation Unitwith an extensive psychiatric history and who are unable to participate in rehabilitation due to current active medical condition/sRecruitment processesPatientsPatients who are potential participants will be informed of the research and invited to participate by a member of the research team. The purpose of the study and the procedures involved will be explained, and patients who express an interest in participation will be provided with a Participant Information Sheet (see Participant Information Sheet), Consent Form and Revocation form.Some potential participants may not have capacity to consent for themselves because of cognitive or language impairments e.g. aphasia from stroke. A patient’s capacity to decide whether or not to participate will be determined by the treating medical team. If the patient lacks capacity to consent to the study the substitute decision maker will be approached and provided with information regarding the study. If the patient or substitute decision maker is interested in the study, the recruiting staff member will supply full information, including the participant information form and the consent form. When supplying the information to the participant, the study will be explained in more detail, including the risks involved e.g. skin irritation from wearing the Stepwatch activity monitor on the ankle. Patient and substitute decision makers will be informed that participation is voluntary and that they will receive normal care if not participating. All questions will be answered before seeking consent for study participation. Once signed consent is obtained, the patient will be enrolled in the study.Conditions of participation (eg. Withdrawal)PatientsParticipants will be informed that their agreement or refusal to participate in the study will not affect their relationship with their therapists or the services they receive. If they consent to participate in the study they will maintain the right to withdraw at any stage and will not be required to state a reason for doing so. Their decision to withdraw will not affect their relationship with therapists or the therapy and medical services they receive. Patients can withdraw at any time from the study by signing the revocation form, which will be attached to the copy of the Information and Consent Form.Risks to ParticipantsThere are no identified risks to patients who choose to participate in this study as this is not an interventional study. To minimize risk for skin irritation we will check the skin for any signs of irritation after 2 hours wearing time. In the case of skin redness, itch or other irritation is noticed, sensor-based physical activity observations will be terminated.OUTCOME MEASURESData collection methods/ types of data to be collectedMethods of Activity Monitoring:Behavioral mappingAnkle mounted accelerometer (Stepwatch) Upper limb wrist mounted accelerometer (Actigraph)ParticipantsBehavioral mapping Activity:One method of observing activity of participants is through structured observations (behavioral mapping) at 10-minute intervals. The behavioral mapping protocol by Janssen et al 2012 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc2VuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48

UmVjTnVtPjE4PC9SZWNOdW0+PERpc3BsYXlUZXh0PlszN108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQy

MjAxMzA2OSI+MTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkphbnNz

ZW4sIEguPC9hdXRob3I+PGF1dGhvcj5BZGEsIEwuPC9hdXRob3I+PGF1dGhvcj5LYXJheWFuaWRp

cywgRi48L2F1dGhvcj48YXV0aG9yPkRyeXNkYWxlLCBLLjwvYXV0aG9yPjxhdXRob3I+TWNFbGR1

ZmYsIFAuPC9hdXRob3I+PGF1dGhvcj5Qb2xsYWNrLCBNLjwvYXV0aG9yPjxhdXRob3I+V2hpdGUs

IEouPC9hdXRob3I+PGF1dGhvcj5OaWxzc29uLCBNLjwvYXV0aG9yPjxhdXRob3I+QmVybmhhcmR0

LCBKLjwvYXV0aG9yPjxhdXRob3I+U3ByYXR0LCBOLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZhY3VsdHkgb2YgSGVhbHRoLCBVbml2ZXJzaXR5IG9m

IE5ld2Nhc3RsZSBhbmQgSHVudGVyIE1lZGljYWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBOZXdjYXN0

bGUsIE5TVywgQXVzdHJhbGlhLiBjOTcwODE1OUB1b24uZWR1LmF1PC9hdXRoLWFkZHJlc3M+PHRp

dGxlcz48dGl0bGU+VHJhbnNsYXRpbmcgdGhlIHVzZSBvZiBhbiBlbnJpY2hlZCBlbnZpcm9ubWVu

dCBwb3N0c3Ryb2tlIGZyb20gYmVuY2ggdG8gYmVkc2lkZTogc3R1ZHkgZGVzaWduIGFuZCBwcm90

b2NvbCB1c2VkIHRvIHRlc3QgdGhlIGZlYXNpYmlsaXR5IG9mIGVudmlyb25tZW50YWwgZW5yaWNo

bWVudCBvbiBzdHJva2UgcGF0aWVudHMgaW4gcmVoYWJpbGl0YXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+SW50IEogU3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5JbnRlcm5h

dGlvbmFsIGpvdXJuYWwgb2Ygc3Ryb2tlIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJu

YXRpb25hbCBTdHJva2UgU29jaWV0eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkludCBKIFN0cm9rZTwvZnVsbC10aXRsZT48YWJici0xPkludGVybmF0aW9uYWwg

am91cm5hbCBvZiBzdHJva2UgOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFs

IFN0cm9rZSBTb2NpZXR5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5JbnQgSiBTdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5JbnRlcm5hdGlvbmFsIGpv

dXJuYWwgb2Ygc3Ryb2tlIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBT

dHJva2UgU29jaWV0eTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjUyMS02PC9wYWdl

cz48dm9sdW1lPjc8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4yMDEyLzAxLzI0

PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qQWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8

L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aW9uL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

RGlmZnVzaW9uIG9mIElubm92YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RXhlcmNpc2UvcGh5c2lv

bG9neTwva2V5d29yZD48a2V5d29yZD5GZWFzaWJpbGl0eSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPkhlYWx0aCBCZWhhdmlvcjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW50ZXJwZXJzb25hbCBSZWxhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2ZXIg

VmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlBpbG90IFByb2plY3RzPC9rZXl3b3JkPjxrZXl3

b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UHN5Y2hvbW90b3IgUGVy

Zm9ybWFuY2UvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlv

bjwva2V5d29yZD48a2V5d29yZD4qU29jaWFsIEVudmlyb25tZW50PC9rZXl3b3JkPjxrZXl3b3Jk

PlN0cm9rZS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE3NDctNDkzMDwvaXNibj48YWNjZXNzaW9uLW51bT4yMjI2NDIxOTwvYWNjZXNzaW9u

LW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNzQ3

LTQ5NDkuMjAxMS4wMDcyNy54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFi

YXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8

L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AAA=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc2VuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48

UmVjTnVtPjE4PC9SZWNOdW0+PERpc3BsYXlUZXh0PlszN108L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+MTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVzdGFtcD0iMTQy

MjAxMzA2OSI+MTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkphbnNz

ZW4sIEguPC9hdXRob3I+PGF1dGhvcj5BZGEsIEwuPC9hdXRob3I+PGF1dGhvcj5LYXJheWFuaWRp

cywgRi48L2F1dGhvcj48YXV0aG9yPkRyeXNkYWxlLCBLLjwvYXV0aG9yPjxhdXRob3I+TWNFbGR1

ZmYsIFAuPC9hdXRob3I+PGF1dGhvcj5Qb2xsYWNrLCBNLjwvYXV0aG9yPjxhdXRob3I+V2hpdGUs

IEouPC9hdXRob3I+PGF1dGhvcj5OaWxzc29uLCBNLjwvYXV0aG9yPjxhdXRob3I+QmVybmhhcmR0

LCBKLjwvYXV0aG9yPjxhdXRob3I+U3ByYXR0LCBOLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZhY3VsdHkgb2YgSGVhbHRoLCBVbml2ZXJzaXR5IG9m

IE5ld2Nhc3RsZSBhbmQgSHVudGVyIE1lZGljYWwgUmVzZWFyY2ggSW5zdGl0dXRlLCBOZXdjYXN0

bGUsIE5TVywgQXVzdHJhbGlhLiBjOTcwODE1OUB1b24uZWR1LmF1PC9hdXRoLWFkZHJlc3M+PHRp

dGxlcz48dGl0bGU+VHJhbnNsYXRpbmcgdGhlIHVzZSBvZiBhbiBlbnJpY2hlZCBlbnZpcm9ubWVu

dCBwb3N0c3Ryb2tlIGZyb20gYmVuY2ggdG8gYmVkc2lkZTogc3R1ZHkgZGVzaWduIGFuZCBwcm90

b2NvbCB1c2VkIHRvIHRlc3QgdGhlIGZlYXNpYmlsaXR5IG9mIGVudmlyb25tZW50YWwgZW5yaWNo

bWVudCBvbiBzdHJva2UgcGF0aWVudHMgaW4gcmVoYWJpbGl0YXRpb248L3RpdGxlPjxzZWNvbmRh

cnktdGl0bGU+SW50IEogU3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5JbnRlcm5h

dGlvbmFsIGpvdXJuYWwgb2Ygc3Ryb2tlIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJu

YXRpb25hbCBTdHJva2UgU29jaWV0eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxm

dWxsLXRpdGxlPkludCBKIFN0cm9rZTwvZnVsbC10aXRsZT48YWJici0xPkludGVybmF0aW9uYWwg

am91cm5hbCBvZiBzdHJva2UgOiBvZmZpY2lhbCBqb3VybmFsIG9mIHRoZSBJbnRlcm5hdGlvbmFs

IFN0cm9rZSBTb2NpZXR5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5JbnQgSiBTdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5JbnRlcm5hdGlvbmFsIGpv

dXJuYWwgb2Ygc3Ryb2tlIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgSW50ZXJuYXRpb25hbCBT

dHJva2UgU29jaWV0eTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjUyMS02PC9wYWdl

cz48dm9sdW1lPjc8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlvbj4yMDEyLzAxLzI0

PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qQWN0aXZpdGllcyBvZiBEYWlseSBMaXZpbmc8

L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aW9uL3BoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+

RGlmZnVzaW9uIG9mIElubm92YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+RXhlcmNpc2UvcGh5c2lv

bG9neTwva2V5d29yZD48a2V5d29yZD5GZWFzaWJpbGl0eSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3

b3JkPkhlYWx0aCBCZWhhdmlvcjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl

eXdvcmQ+SW50ZXJwZXJzb25hbCBSZWxhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2ZXIg

VmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlBpbG90IFByb2plY3RzPC9rZXl3b3JkPjxrZXl3

b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UHN5Y2hvbW90b3IgUGVy

Zm9ybWFuY2UvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlv

bjwva2V5d29yZD48a2V5d29yZD4qU29jaWFsIEVudmlyb25tZW50PC9rZXl3b3JkPjxrZXl3b3Jk

PlN0cm9rZS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE3NDctNDkzMDwvaXNibj48YWNjZXNzaW9uLW51bT4yMjI2NDIxOTwvYWNjZXNzaW9u

LW51bT48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvai4xNzQ3

LTQ5NDkuMjAxMS4wMDcyNy54PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFi

YXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8

L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AAA=

ADDIN EN.CITE.DATA [37] will be used and adjusted for the inpatient rehab setting. In this mapping protocol processes are outlined and definitions of activity domains are specified. The data observation recording sheet with embedded checklist has been developed specifically for this protocol. Behavioral mapping has been extensively used in observational research involving stroke patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW5nPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj

TnVtPjg8L1JlY051bT48RGlzcGxheVRleHQ+WzMwLCAzMSwgMzgsIDM5XTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj44PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3Rh

bXA9IjE0NjE3MzE2NzAiPjg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkxhbmcsIEMuIEUuPC9hdXRob3I+PGF1dGhvcj5NYWNkb25hbGQsIEouIFIuPC9hdXRob3I+PGF1

dGhvcj5SZWlzbWFuLCBELiBTLjwvYXV0aG9yPjxhdXRob3I+Qm95ZCwgTC48L2F1dGhvcj48YXV0

aG9yPkphY29ic29uIEtpbWJlcmxleSwgVC48L2F1dGhvcj48YXV0aG9yPlNjaGluZGxlci1JdmVu

cywgUy4gTS48L2F1dGhvcj48YXV0aG9yPkhvcm5ieSwgVC4gRy48L2F1dGhvcj48YXV0aG9yPlJv

c3MsIFMuIEEuPC9hdXRob3I+PGF1dGhvcj5TY2hlZXRzLCBQLiBMLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByb2dyYW0gaW4gUGh5c2ljYWwgVGhlcmFw

eSwgUHJvZ3JhbSBpbiBPY2N1cGF0aW9uYWwgVGhlcmFweSwgYW5kIERlcGFydG1lbnQgb2YgTmV1

cm9sb2d5LCBXYXNoaW5ndG9uIFVuaXZlcnNpdHksIFN0LiBMb3VpcywgTU8sIFVTQS4gbGFuZ2NA

d3VzdGwuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+T2JzZXJ2YXRpb24gb2YgYW1v

dW50cyBvZiBtb3ZlbWVudCBwcmFjdGljZSBwcm92aWRlZCBkdXJpbmcgc3Ryb2tlIHJlaGFiaWxp

dGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFyY2ggUGh5cyBNZWQgUmVoYWJpbDwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaGl2ZXMgb2YgcGh5c2ljYWwgbWVkaWNpbmUgYW5k

IHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QXJjaGl2ZXMgb2Yg

cGh5c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMgTWVkIFJlaGFiaWw8L2Z1bGwt

dGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0

YXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNjkyLTg8L3BhZ2VzPjx2b2x1

bWU+OTA8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVkaXRpb24+MjAwOS8xMC8wNjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3Rv

cnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQg

b3Zlcjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPkxvd2VyIEV4dHJlbWl0eS8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtl

eXdvcmQ+Kk1vdmVtZW50PC9rZXl3b3JkPjxrZXl3b3JkPk9jY3VwYXRpb25hbCBUaGVyYXB5Lypt

ZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPipQaHlzaWNhbCBUaGVyYXB5IE1vZGFsaXRpZXM8L2tl

eXdvcmQ+PGtleXdvcmQ+UmVjb3Zlcnkgb2YgRnVuY3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+U3Ry

b2tlL3BoeXNpb3BhdGhvbG9neS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+VGlt

ZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlVwcGVyIEV4dHJlbWl0eS8qcGh5c2lvcGF0aG9s

b2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTM8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTk4MDEwNTg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxj

dXN0b20yPlBtYzMwMDg1NTg8L2N1c3RvbTI+PGN1c3RvbTY+TmlobXMyNTczNTk8L2N1c3RvbTY+

PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5hcG1yLjIwMDkuMDQuMDA1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPk1hY2tleTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJlY051bT42

MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5

cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJm

MHIiIHRpbWVzdGFtcD0iMTQyMjE4MDA0NCI+NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPk1hY2tleSwgRi48L2F1dGhvcj48YXV0aG9yPkFkYSwgTC48L2F1dGhvcj48

YXV0aG9yPkhlYXJkLCBSLjwvYXV0aG9yPjxhdXRob3I+QWRhbXMsIFIuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGh5c2lvdGhlcmFweSBEZXBhcnRtZW50

LCBJbGxhd2FycmEgUmVnaW9uYWwgSG9zcGl0YWwsIFdvbGxvbmdvbmcsIEF1c3RyYWxpYS48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TdHJva2UgcmVoYWJpbGl0YXRpb246IGFyZSBoaWdo

bHkgc3RydWN0dXJlZCB1bml0cyBtb3JlIGNvbmR1Y2l2ZSB0byBwaHlzaWNhbCBhY3Rpdml0eSB0

aGFuIGxlc3Mgc3RydWN0dXJlZCB1bml0cz88L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QXJjaCBQ

aHlzIE1lZCBSZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BcmNoaXZlcyBvZiBw

aHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMgTWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+

PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRpb248

L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFyY2ggUGh5

cyBNZWQgUmVoYWJpbDwvZnVsbC10aXRsZT48YWJici0xPkFyY2hpdmVzIG9mIHBoeXNpY2FsIG1l

ZGljaW5lIGFuZCByZWhhYmlsaXRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjEwNjYtNzA8L3BhZ2VzPjx2b2x1bWU+Nzc8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVk

aXRpb24+MTk5Ni8xMC8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5DZXJlYnJvdmFz

Y3VsYXIgRGlzb3JkZXJzLypyZWhhYmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5GYWNpbGl0

eSBEZXNpZ24gYW5kIENvbnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdv

cmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Kk1vdG9yIEFjdGl2aXR5PC9rZXl3b3Jk

PjxrZXl3b3JkPlJlaGFiaWxpdGF0aW9uIENlbnRlcnMvKm9yZ2FuaXphdGlvbiAmYW1wOyBhZG1p

bmlzdHJhdGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwMy05

OTkzIChQcmludCkmI3hEOzAwMDMtOTk5MzwvaXNibj48YWNjZXNzaW9uLW51bT44ODU3ODg4PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwv

cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlRvbGU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO

dW0+Mzc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjM3PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpl

d3gwMDV2IiB0aW1lc3RhbXA9IjE0NjE3Mzk1MDAiPjM3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5HZW5ldmlldmUgVG9sZTwvYXV0aG9yPjxhdXRob3I+R2F2aW4gV2ls

bGlhbXM8L2F1dGhvcj48YXV0aG9yPlJvc3MgQ2xhcms8L2F1dGhvcj48YXV0aG9yPkFubmUgRSBI

b2xsYW5kPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkFu

IG9ic2VydmF0aW9uYWwgc3R1ZHkgb24gdXN1YWwgcGh5c2lvdGhlcmFweSBjYXJlIGluIGEgc3Ry

b2tlIHJlaGFiaWxpdGF0aW9uIHVuaXQgZm9yIHBhdGllbnRzIHdpdGggbW9iaWxpdHkgZGVmaWNp

dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIFRoZXJh

cHkgYW5kIFJlaGFiaWxpdGF0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIFRoZXJhcHkgYW5kIFJlaGFi

aWxpdGF0aW9uPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NTg1LTU4OTwvcGFnZXM+

PHZvbHVtZT4yMTwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+

SW50ZXJ2ZW50aW9uLFBoeXNpb3RoZXJhcHksUmVoYWJpbGl0YXRpb24sU3Ryb2tlLFVzdWFsIGNh

cmU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm1hZ29ubGluZWxpYnJhcnkuY29tL2Rv

aS9hYnMvMTAuMTI5NjgvaWp0ci4yMDE0LjIxLjEyLjU4NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+ZG9pOjEwLjEyOTY4L2lqdHIuMjAxNC4yMS4x

Mi41ODU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkJlcm5oYXJkdDwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4xNDwvUmVjTnVt

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVz

dGFtcD0iMTQyMjAxMDA5NyI+MTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkJlcm5oYXJkdCwgSi48L2F1dGhvcj48YXV0aG9yPkRld2V5LCBILjwvYXV0aG9yPjxhdXRo

b3I+VGhyaWZ0LCBBLjwvYXV0aG9yPjxhdXRob3I+RG9ubmFuLCBHLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk5hdGlvbmFsIFN0cm9rZSBSZXNlYXJjaCBJ

bnN0aXR1dGUsIEF1c3RpbiBIZWFsdGgsIEhlaWRlbGJlcmcgUmVwYXRyaWF0aW9uIEhvc3BpdGFs

LCBIZWlkZWxiZXJnLCBWaWN0b3JpYSwgQXVzdHJhbGlhLiBKYmVybmhhcmR0QGF1c3Rpbi51bmlt

ZWxiLmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluYWN0aXZlIGFuZCBhbG9u

ZTogcGh5c2ljYWwgYWN0aXZpdHkgd2l0aGluIHRoZSBmaXJzdCAxNCBkYXlzIG9mIGFjdXRlIHN0

cm9rZSB1bml0IGNhcmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlv

bjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVs

bC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBqb3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9u

PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8

L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxh

dGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwMDUtOTwvcGFnZXM+PHZvbHVt

ZT4zNTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDIvMjg8L2VkaXRp

b24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+QWR1

bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5CZWQgUmVzdDwva2V5

d29yZD48a2V5d29yZD4qRWFybHkgQW1idWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8

L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tl

eXdvcmQ+PGtleXdvcmQ+TW90b3IgQWN0aXZpdHk8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2ZXIg

VmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS9kaWFnbm9zaXMvKnJlaGFiaWxpdGF0

aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0OTg4NTc0

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu

MTE2MS8wMS5zdHIuMDAwMDEyMDcyNy40MDc5Mi40MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW5nPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48UmVj

TnVtPjg8L1JlY051bT48RGlzcGxheVRleHQ+WzMwLCAzMSwgMzgsIDM5XTwvRGlzcGxheVRleHQ+

PHJlY29yZD48cmVjLW51bWJlcj44PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3Rh

bXA9IjE0NjE3MzE2NzAiPjg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PkxhbmcsIEMuIEUuPC9hdXRob3I+PGF1dGhvcj5NYWNkb25hbGQsIEouIFIuPC9hdXRob3I+PGF1

dGhvcj5SZWlzbWFuLCBELiBTLjwvYXV0aG9yPjxhdXRob3I+Qm95ZCwgTC48L2F1dGhvcj48YXV0

aG9yPkphY29ic29uIEtpbWJlcmxleSwgVC48L2F1dGhvcj48YXV0aG9yPlNjaGluZGxlci1JdmVu

cywgUy4gTS48L2F1dGhvcj48YXV0aG9yPkhvcm5ieSwgVC4gRy48L2F1dGhvcj48YXV0aG9yPlJv

c3MsIFMuIEEuPC9hdXRob3I+PGF1dGhvcj5TY2hlZXRzLCBQLiBMLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByb2dyYW0gaW4gUGh5c2ljYWwgVGhlcmFw

eSwgUHJvZ3JhbSBpbiBPY2N1cGF0aW9uYWwgVGhlcmFweSwgYW5kIERlcGFydG1lbnQgb2YgTmV1

cm9sb2d5LCBXYXNoaW5ndG9uIFVuaXZlcnNpdHksIFN0LiBMb3VpcywgTU8sIFVTQS4gbGFuZ2NA

d3VzdGwuZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+T2JzZXJ2YXRpb24gb2YgYW1v

dW50cyBvZiBtb3ZlbWVudCBwcmFjdGljZSBwcm92aWRlZCBkdXJpbmcgc3Ryb2tlIHJlaGFiaWxp

dGF0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFyY2ggUGh5cyBNZWQgUmVoYWJpbDwvc2Vj

b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QXJjaGl2ZXMgb2YgcGh5c2ljYWwgbWVkaWNpbmUgYW5k

IHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0

bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9mdWxsLXRpdGxlPjxhYmJyLTE+QXJjaGl2ZXMgb2Yg

cGh5c2ljYWwgbWVkaWNpbmUgYW5kIHJlaGFiaWxpdGF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2Fs

PjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMgTWVkIFJlaGFiaWw8L2Z1bGwt

dGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0

YXRpb248L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNjkyLTg8L3BhZ2VzPjx2b2x1

bWU+OTA8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVkaXRpb24+MjAwOS8xMC8wNjwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3Rv

cnM8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQg

b3Zlcjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPkxvd2VyIEV4dHJlbWl0eS8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3Jk

PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtl

eXdvcmQ+Kk1vdmVtZW50PC9rZXl3b3JkPjxrZXl3b3JkPk9jY3VwYXRpb25hbCBUaGVyYXB5Lypt

ZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPipQaHlzaWNhbCBUaGVyYXB5IE1vZGFsaXRpZXM8L2tl

eXdvcmQ+PGtleXdvcmQ+UmVjb3Zlcnkgb2YgRnVuY3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+U3Ry

b2tlL3BoeXNpb3BhdGhvbG9neS8qcmVoYWJpbGl0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+VGlt

ZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlVwcGVyIEV4dHJlbWl0eS8qcGh5c2lvcGF0aG9s

b2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRl

cz48ZGF0ZT5PY3Q8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTM8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MTk4MDEwNTg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxj

dXN0b20yPlBtYzMwMDg1NTg8L2N1c3RvbTI+PGN1c3RvbTY+TmlobXMyNTczNTk8L2N1c3RvbTY+

PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5hcG1yLjIwMDkuMDQuMDA1PC9lbGVj

dHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48Q2l0ZT48QXV0aG9yPk1hY2tleTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJlY051bT42

MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5

cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJm

MHIiIHRpbWVzdGFtcD0iMTQyMjE4MDA0NCI+NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPk1hY2tleSwgRi48L2F1dGhvcj48YXV0aG9yPkFkYSwgTC48L2F1dGhvcj48

YXV0aG9yPkhlYXJkLCBSLjwvYXV0aG9yPjxhdXRob3I+QWRhbXMsIFIuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGh5c2lvdGhlcmFweSBEZXBhcnRtZW50

LCBJbGxhd2FycmEgUmVnaW9uYWwgSG9zcGl0YWwsIFdvbGxvbmdvbmcsIEF1c3RyYWxpYS48L2F1

dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TdHJva2UgcmVoYWJpbGl0YXRpb246IGFyZSBoaWdo

bHkgc3RydWN0dXJlZCB1bml0cyBtb3JlIGNvbmR1Y2l2ZSB0byBwaHlzaWNhbCBhY3Rpdml0eSB0

aGFuIGxlc3Mgc3RydWN0dXJlZCB1bml0cz88L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QXJjaCBQ

aHlzIE1lZCBSZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5BcmNoaXZlcyBvZiBw

aHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FsdC10aXRsZT48L3RpdGxlcz48

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMgTWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+

PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRpb248

L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFyY2ggUGh5

cyBNZWQgUmVoYWJpbDwvZnVsbC10aXRsZT48YWJici0xPkFyY2hpdmVzIG9mIHBoeXNpY2FsIG1l

ZGljaW5lIGFuZCByZWhhYmlsaXRhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2Vz

PjEwNjYtNzA8L3BhZ2VzPjx2b2x1bWU+Nzc8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVk

aXRpb24+MTk5Ni8xMC8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29y

ZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5DZXJlYnJvdmFz

Y3VsYXIgRGlzb3JkZXJzLypyZWhhYmlsaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5GYWNpbGl0

eSBEZXNpZ24gYW5kIENvbnN0cnVjdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdv

cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdv

cmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Kk1vdG9yIEFjdGl2aXR5PC9rZXl3b3Jk

PjxrZXl3b3JkPlJlaGFiaWxpdGF0aW9uIENlbnRlcnMvKm9yZ2FuaXphdGlvbiAmYW1wOyBhZG1p

bmlzdHJhdGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk2PC95ZWFyPjxw

dWItZGF0ZXM+PGRhdGU+T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwMy05

OTkzIChQcmludCkmI3hEOzAwMDMtOTk5MzwvaXNibj48YWNjZXNzaW9uLW51bT44ODU3ODg4PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwv

cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3Jk

PjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlRvbGU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO

dW0+Mzc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjM3PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpl

d3gwMDV2IiB0aW1lc3RhbXA9IjE0NjE3Mzk1MDAiPjM3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5HZW5ldmlldmUgVG9sZTwvYXV0aG9yPjxhdXRob3I+R2F2aW4gV2ls

bGlhbXM8L2F1dGhvcj48YXV0aG9yPlJvc3MgQ2xhcms8L2F1dGhvcj48YXV0aG9yPkFubmUgRSBI

b2xsYW5kPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkFu

IG9ic2VydmF0aW9uYWwgc3R1ZHkgb24gdXN1YWwgcGh5c2lvdGhlcmFweSBjYXJlIGluIGEgc3Ry

b2tlIHJlaGFiaWxpdGF0aW9uIHVuaXQgZm9yIHBhdGllbnRzIHdpdGggbW9iaWxpdHkgZGVmaWNp

dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIFRoZXJh

cHkgYW5kIFJlaGFiaWxpdGF0aW9uPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIFRoZXJhcHkgYW5kIFJlaGFi

aWxpdGF0aW9uPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NTg1LTU4OTwvcGFnZXM+

PHZvbHVtZT4yMTwvdm9sdW1lPjxudW1iZXI+MTI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+

SW50ZXJ2ZW50aW9uLFBoeXNpb3RoZXJhcHksUmVoYWJpbGl0YXRpb24sU3Ryb2tlLFVzdWFsIGNh

cmU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48L2RhdGVzPjx1

cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm1hZ29ubGluZWxpYnJhcnkuY29tL2Rv

aS9hYnMvMTAuMTI5NjgvaWp0ci4yMDE0LjIxLjEyLjU4NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwv

dXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+ZG9pOjEwLjEyOTY4L2lqdHIuMjAxNC4yMS4x

Mi41ODU8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0

aG9yPkJlcm5oYXJkdDwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4xNDwvUmVjTnVt

PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJzMmYwZnowYW9zdHRmaWV4ZjlseDA5ZDQ5MnR0ZHZmdzJmMHIiIHRpbWVz

dGFtcD0iMTQyMjAxMDA5NyI+MTQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkJlcm5oYXJkdCwgSi48L2F1dGhvcj48YXV0aG9yPkRld2V5LCBILjwvYXV0aG9yPjxhdXRo

b3I+VGhyaWZ0LCBBLjwvYXV0aG9yPjxhdXRob3I+RG9ubmFuLCBHLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk5hdGlvbmFsIFN0cm9rZSBSZXNlYXJjaCBJ

bnN0aXR1dGUsIEF1c3RpbiBIZWFsdGgsIEhlaWRlbGJlcmcgUmVwYXRyaWF0aW9uIEhvc3BpdGFs

LCBIZWlkZWxiZXJnLCBWaWN0b3JpYSwgQXVzdHJhbGlhLiBKYmVybmhhcmR0QGF1c3Rpbi51bmlt

ZWxiLmVkdS5hdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluYWN0aXZlIGFuZCBhbG9u

ZTogcGh5c2ljYWwgYWN0aXZpdHkgd2l0aGluIHRoZSBmaXJzdCAxNCBkYXlzIG9mIGFjdXRlIHN0

cm9rZSB1bml0IGNhcmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlv

bjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVs

bC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBqb3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9u

PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8

L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxh

dGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEwMDUtOTwvcGFnZXM+PHZvbHVt

ZT4zNTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDIvMjg8L2VkaXRp

b24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+QWR1

bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5CZWQgUmVzdDwva2V5

d29yZD48a2V5d29yZD4qRWFybHkgQW1idWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8

L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z

PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tl

eXdvcmQ+PGtleXdvcmQ+TW90b3IgQWN0aXZpdHk8L2tleXdvcmQ+PGtleXdvcmQ+T2JzZXJ2ZXIg

VmFyaWF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlN0cm9rZS9kaWFnbm9zaXMvKnJlaGFiaWxpdGF0

aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxk

YXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRh

dGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE0OTg4NTc0

PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu

MTE2MS8wMS5zdHIuMDAwMDEyMDcyNy40MDc5Mi40MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+

PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48

bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE.DATA [30, 31, 38, 39] Utilizing the observational recording sheet makes it possible to observe more than one person; using checklists that record the patient’s type of activities, their location, patient’s position and whether other persons are present.The observational data recording sheets will be used for one weekday and one weekend day in the same week from 8:00 am till 5:00 pm. Over the period of 9 hours, patients will be observed for 1-minute at 10 minute intervals and activities observed will be recorded. Behavioral mapping staff can take a break from 10:10-10:30, 13:00-13:30 and 15:20 -15:30 so in total 48 observations are made in one day. (behavioral mapping protocol, behavioral mapping explanation document and final mapping recording sheets attached in appendix)Training of staff and studentsStaff and students undertaking placements with the hospital staff members involved in recording observational data will be trained in the behavioral mapping protocol, behavioral mapping explanation document and in utilizing the observational data mapping recording sheets. After the training the staff member will observe 4 different patients for one hour, providing 24 observations using the data recording sheets. Staff will be able to record data during the trial when the total number of observations are ≥ 90% accuracy as assessed concurrently by the educator. A list of all staff and students that passed the test will be recorded. Activity MonitoringInstrumented monitoring of physical activity of participants will be performed using Stepwatch ankle mounted activity monitors for gait, and bilateral wrist mounted Actigraph accelerometers for upper limb activity. This will monitor participant’s physical activity for 3 consecutive days. These monitors are worn around the ankle of the less affected side, and both wrists during the entire period to provide outcome measures for the total number of steps, sedentary time, upper limb activity counts performed per day and sleep quality PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0aW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS

ZWNOdW0+MzE8L1JlY051bT48RGlzcGxheVRleHQ+WzMzLCA0MF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJlencwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYiIHRpbWVzdGFtcD0i

MTQ2MTczNDUzOSI+MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1h

cnRpbiwgSi4gTC48L2F1dGhvcj48YXV0aG9yPkhha2ltLCBBLiBELjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlZBIEdyZWF0ZXIgTG9zIEFuZ2VsZXMgSGVh

bHRoY2FyZSBTeXN0ZW0sIEdlcmlhdHJpYyBSZXNlYXJjaCwgRWR1Y2F0aW9uLCBhbmQgQ2xpbmlj

YWwgQ2VudGVyLCBMb3MgQW5nZWxlcywgQ0EsIFVTQS4gamVubmlmZXIubWFydGluQHZhLmdvdjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPldyaXN0IGFjdGlncmFwaHk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Q2hlc3Q8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNoZXN0PC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2hlc3Q8L2Z1bGwtdGl0bGU+

PGFiYnItMT5DaGVzdDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Q2hlc3Q8L2Z1bGwtdGl0bGU+PGFiYnItMT5DaGVzdDwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjE1MTQtMjc8L3BhZ2VzPjx2b2x1bWU+MTM5PC92b2x1bWU+PG51bWJlcj42

PC9udW1iZXI+PGVkaXRpb24+MjAxMS8wNi8xMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+

KkFjdGlncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPlJl

cHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIFdha2UgRGlz

b3JkZXJzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+V3Jpc3Q8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMTItMzY5MjwvaXNibj48YWNjZXNzaW9uLW51bT4y

MTY1MjU2MzwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+UG1jMzEwOTY0Nzwv

Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTM3OC9jaGVzdC4xMC0xODcyPC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkhheXdhcmQ8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNO

dW0+Mzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjM4PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpl

d3gwMDV2IiB0aW1lc3RhbXA9IjE0NjE3Mzk5OTAiPjM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5IYXl3YXJkLEthdGhyeW4gUy48L2F1dGhvcj48YXV0aG9yPkVuZyxK

YW5pY2UgSi48L2F1dGhvcj48YXV0aG9yPkJveWQsTGFyYSBBLjwvYXV0aG9yPjxhdXRob3I+TGFr

aGFuaSxCaW1hbDwvYXV0aG9yPjxhdXRob3I+QmVybmhhcmR0LEp1bGllPC9hdXRob3I+PGF1dGhv

cj5MYW5nLENhdGhlcmluZSBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0

bGVzPjx0aXRsZT5FeHBsb3JpbmcgdGhlIFJvbGUgb2YgQWNjZWxlcm9tZXRlcnMgaW4gdGhlIE1l

YXN1cmVtZW50IG9mIFJlYWwgV29ybGQgVXBwZXItTGltYiBVc2UgQWZ0ZXIgU3Ryb2tlPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkJyYWluIEltcGFpcm1lbnQ8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CcmFpbiBJbXBhaXJtZW50PC9mdWxsLXRpdGxl

PjwvcGVyaW9kaWNhbD48cGFnZXM+MTYtMzM8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVt

YmVyPlNwZWNpYWwgSXNzdWUgMDE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+c3Ryb2tlLHBh

cmVzaXMsYWNjZWxlcm9tZXRyeSx3ZWFyYWJsZSBzZW5zb3JzLGFybSxyZWNvdmVyeTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTgzOS01

MjUyPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDE3L0JySW1wLjIwMTUuMjE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPmRvaToxMC4xMDE3L0JySW1wLjIwMTUuMjE8L2VsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjxhY2Nlc3MtZGF0ZT4yMDE2PC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJ0aW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS

ZWNOdW0+MzE8L1JlY051bT48RGlzcGxheVRleHQ+WzMzLCA0MF08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+MzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJlencwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYiIHRpbWVzdGFtcD0i

MTQ2MTczNDUzOSI+MzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1h

cnRpbiwgSi4gTC48L2F1dGhvcj48YXV0aG9yPkhha2ltLCBBLiBELjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlZBIEdyZWF0ZXIgTG9zIEFuZ2VsZXMgSGVh

bHRoY2FyZSBTeXN0ZW0sIEdlcmlhdHJpYyBSZXNlYXJjaCwgRWR1Y2F0aW9uLCBhbmQgQ2xpbmlj

YWwgQ2VudGVyLCBMb3MgQW5nZWxlcywgQ0EsIFVTQS4gamVubmlmZXIubWFydGluQHZhLmdvdjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPldyaXN0IGFjdGlncmFwaHk8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+Q2hlc3Q8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNoZXN0PC9hbHQt

dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Q2hlc3Q8L2Z1bGwtdGl0bGU+

PGFiYnItMT5DaGVzdDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+Q2hlc3Q8L2Z1bGwtdGl0bGU+PGFiYnItMT5DaGVzdDwvYWJici0xPjwvYWx0LXBlcmlv

ZGljYWw+PHBhZ2VzPjE1MTQtMjc8L3BhZ2VzPjx2b2x1bWU+MTM5PC92b2x1bWU+PG51bWJlcj42

PC9udW1iZXI+PGVkaXRpb24+MjAxMS8wNi8xMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+

KkFjdGlncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPlJl

cHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIFdha2UgRGlz

b3JkZXJzLypkaWFnbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+V3Jpc3Q8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bjwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMTItMzY5MjwvaXNibj48YWNjZXNzaW9uLW51bT4y

MTY1MjU2MzwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3RvbTI+UG1jMzEwOTY0Nzwv

Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTM3OC9jaGVzdC4xMC0xODcyPC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkhheXdhcmQ8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNO

dW0+Mzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjM4PC9yZWMtbnVtYmVyPjxmb3JlaWdu

LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpl

d3gwMDV2IiB0aW1lc3RhbXA9IjE0NjE3Mzk5OTAiPjM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJl

Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+

PGF1dGhvcnM+PGF1dGhvcj5IYXl3YXJkLEthdGhyeW4gUy48L2F1dGhvcj48YXV0aG9yPkVuZyxK

YW5pY2UgSi48L2F1dGhvcj48YXV0aG9yPkJveWQsTGFyYSBBLjwvYXV0aG9yPjxhdXRob3I+TGFr

aGFuaSxCaW1hbDwvYXV0aG9yPjxhdXRob3I+QmVybmhhcmR0LEp1bGllPC9hdXRob3I+PGF1dGhv

cj5MYW5nLENhdGhlcmluZSBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0

bGVzPjx0aXRsZT5FeHBsb3JpbmcgdGhlIFJvbGUgb2YgQWNjZWxlcm9tZXRlcnMgaW4gdGhlIE1l

YXN1cmVtZW50IG9mIFJlYWwgV29ybGQgVXBwZXItTGltYiBVc2UgQWZ0ZXIgU3Ryb2tlPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkJyYWluIEltcGFpcm1lbnQ8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CcmFpbiBJbXBhaXJtZW50PC9mdWxsLXRpdGxl

PjwvcGVyaW9kaWNhbD48cGFnZXM+MTYtMzM8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVt

YmVyPlNwZWNpYWwgSXNzdWUgMDE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+c3Ryb2tlLHBh

cmVzaXMsYWNjZWxlcm9tZXRyeSx3ZWFyYWJsZSBzZW5zb3JzLGFybSxyZWNvdmVyeTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTgzOS01

MjUyPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4x

MDE3L0JySW1wLjIwMTUuMjE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPmRvaToxMC4xMDE3L0JySW1wLjIwMTUuMjE8L2VsZWN0cm9uaWMtcmVzb3Vy

Y2UtbnVtPjxhY2Nlc3MtZGF0ZT4yMDE2PC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PC9F

bmROb3RlPgAA

ADDIN EN.CITE.DATA [33, 40]. Participants will be given the option to remove the ankle and one wrist accelerometers for sleep. We will encourage that one Actigraph accelerometer be worn during sleep on the non-paretic arm for stroke participants and on the wrist of choice for other participants to monitor sleep. If a participant wants all the accelerometers to be removed during the night we will remove all accelerometers. Following the three days monitoring period the Stepwatch and Actigraph monitors data will be downloaded to a basestation for analysis. These tools are the criterion reference systems for assessing lower and upper body physical activity patterns respectively PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXl3YXJkPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjM4PC9SZWNOdW0+PERpc3BsYXlUZXh0PlszMywgNDFdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9

IjE0NjE3Mzk5OTAiPjM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5I

YXl3YXJkLEthdGhyeW4gUy48L2F1dGhvcj48YXV0aG9yPkVuZyxKYW5pY2UgSi48L2F1dGhvcj48

YXV0aG9yPkJveWQsTGFyYSBBLjwvYXV0aG9yPjxhdXRob3I+TGFraGFuaSxCaW1hbDwvYXV0aG9y

PjxhdXRob3I+QmVybmhhcmR0LEp1bGllPC9hdXRob3I+PGF1dGhvcj5MYW5nLENhdGhlcmluZSBF

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5FeHBsb3Jp

bmcgdGhlIFJvbGUgb2YgQWNjZWxlcm9tZXRlcnMgaW4gdGhlIE1lYXN1cmVtZW50IG9mIFJlYWwg

V29ybGQgVXBwZXItTGltYiBVc2UgQWZ0ZXIgU3Ryb2tlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkJyYWluIEltcGFpcm1lbnQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5CcmFpbiBJbXBhaXJtZW50PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFn

ZXM+MTYtMzM8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVtYmVyPlNwZWNpYWwgSXNzdWUg

MDE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+c3Ryb2tlLHBhcmVzaXMsYWNjZWxlcm9tZXRy

eSx3ZWFyYWJsZSBzZW5zb3JzLGFybSxyZWNvdmVyeTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTgzOS01MjUyPC9pc2JuPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE3L0JySW1wLjIwMTUuMjE8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmRvaTox

MC4xMDE3L0JySW1wLjIwMTUuMjE8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3MtZGF0

ZT4yMDE2PC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NdWRnZTwv

QXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4zMjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+MzI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJl

encwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYiIHRpbWVzdGFtcD0iMTQ2MTczNDU3

NSI+MzI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk11ZGdlLCBTLjwv

YXV0aG9yPjxhdXRob3I+U3RvdHQsIE4uIFMuPC9hdXRob3I+PGF1dGhvcj5XYWx0LCBTLiBFLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQg

b2YgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBBdWNrbGFuZCwgQXVja2xhbmQsIE5ldyBaZWFsYW5k

LiBzLm11ZGdlQGF1Y2tsYW5kLmFjLm56PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q3Jp

dGVyaW9uIHZhbGlkaXR5IG9mIHRoZSBTdGVwV2F0Y2ggQWN0aXZpdHkgTW9uaXRvciBhcyBhIG1l

YXN1cmUgb2Ygd2Fsa2luZyBhY3Rpdml0eSBpbiBwYXRpZW50cyBhZnRlciBzdHJva2U8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRp

b248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMg

TWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRp

Y2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkFyY2ggUGh5cyBNZWQgUmVoYWJpbDwvZnVsbC10aXRsZT48YWJici0x

PkFyY2hpdmVzIG9mIHBoeXNpY2FsIG1lZGljaW5lIGFuZCByZWhhYmlsaXRhdGlvbjwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE3MTAtNTwvcGFnZXM+PHZvbHVtZT44ODwvdm9sdW1l

PjxudW1iZXI+MTI8L251bWJlcj48ZWRpdGlvbj4yMDA3LzEyLzAxPC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

PkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Nb25pdG9yaW5n

LCBBbWJ1bGF0b3J5L2luc3RydW1lbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Q

YXJlc2lzL3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5TdHJva2UvY2xhc3NpZmlj

YXRpb24vKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPldhbGtpbmcvKmNsYXNzaWZp

Y2F0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTM8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTgwNDc4OTA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouYXBtci4yMDA3LjA3LjAzOTwvZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXl3YXJkPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjM4PC9SZWNOdW0+PERpc3BsYXlUZXh0PlszMywgNDFdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO

IiBkYi1pZD0iZXp3MHI1cng3cDBzenRleHRmenZ6dnJ2dHhkcnpld3gwMDV2IiB0aW1lc3RhbXA9

IjE0NjE3Mzk5OTAiPjM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5I

YXl3YXJkLEthdGhyeW4gUy48L2F1dGhvcj48YXV0aG9yPkVuZyxKYW5pY2UgSi48L2F1dGhvcj48

YXV0aG9yPkJveWQsTGFyYSBBLjwvYXV0aG9yPjxhdXRob3I+TGFraGFuaSxCaW1hbDwvYXV0aG9y

PjxhdXRob3I+QmVybmhhcmR0LEp1bGllPC9hdXRob3I+PGF1dGhvcj5MYW5nLENhdGhlcmluZSBF

LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5FeHBsb3Jp

bmcgdGhlIFJvbGUgb2YgQWNjZWxlcm9tZXRlcnMgaW4gdGhlIE1lYXN1cmVtZW50IG9mIFJlYWwg

V29ybGQgVXBwZXItTGltYiBVc2UgQWZ0ZXIgU3Ryb2tlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl

PkJyYWluIEltcGFpcm1lbnQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5CcmFpbiBJbXBhaXJtZW50PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFn

ZXM+MTYtMzM8L3BhZ2VzPjx2b2x1bWU+MTc8L3ZvbHVtZT48bnVtYmVyPlNwZWNpYWwgSXNzdWUg

MDE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+c3Ryb2tlLHBhcmVzaXMsYWNjZWxlcm9tZXRy

eSx3ZWFyYWJsZSBzZW5zb3JzLGFybSxyZWNvdmVyeTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl

cz48eWVhcj4yMDE2PC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTgzOS01MjUyPC9pc2JuPjx1cmxzPjxy

ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE3L0JySW1wLjIwMTUuMjE8

L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmRvaTox

MC4xMDE3L0JySW1wLjIwMTUuMjE8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxhY2Nlc3MtZGF0

ZT4yMDE2PC9hY2Nlc3MtZGF0ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NdWRnZTwv

QXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4zMjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u

dW1iZXI+MzI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJl

encwcjVyeDdwMHN6dGV4dGZ6dnp2cnZ0eGRyemV3eDAwNXYiIHRpbWVzdGFtcD0iMTQ2MTczNDU3

NSI+MzI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl

Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk11ZGdlLCBTLjwv

YXV0aG9yPjxhdXRob3I+U3RvdHQsIE4uIFMuPC9hdXRob3I+PGF1dGhvcj5XYWx0LCBTLiBFLjwv

YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQg

b2YgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBBdWNrbGFuZCwgQXVja2xhbmQsIE5ldyBaZWFsYW5k

LiBzLm11ZGdlQGF1Y2tsYW5kLmFjLm56PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q3Jp

dGVyaW9uIHZhbGlkaXR5IG9mIHRoZSBTdGVwV2F0Y2ggQWN0aXZpdHkgTW9uaXRvciBhcyBhIG1l

YXN1cmUgb2Ygd2Fsa2luZyBhY3Rpdml0eSBpbiBwYXRpZW50cyBhZnRlciBzdHJva2U8L3RpdGxl

PjxzZWNvbmRhcnktdGl0bGU+QXJjaCBQaHlzIE1lZCBSZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+

PGFsdC10aXRsZT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRpY2luZSBhbmQgcmVoYWJpbGl0YXRp

b248L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BcmNoIFBoeXMg

TWVkIFJlaGFiaWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoaXZlcyBvZiBwaHlzaWNhbCBtZWRp

Y2luZSBhbmQgcmVoYWJpbGl0YXRpb248L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp

Y2FsPjxmdWxsLXRpdGxlPkFyY2ggUGh5cyBNZWQgUmVoYWJpbDwvZnVsbC10aXRsZT48YWJici0x

PkFyY2hpdmVzIG9mIHBoeXNpY2FsIG1lZGljaW5lIGFuZCByZWhhYmlsaXRhdGlvbjwvYWJici0x

PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE3MTAtNTwvcGFnZXM+PHZvbHVtZT44ODwvdm9sdW1l

PjxudW1iZXI+MTI8L251bWJlcj48ZWRpdGlvbj4yMDA3LzEyLzAxPC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

PkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Nb25pdG9yaW5n

LCBBbWJ1bGF0b3J5L2luc3RydW1lbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Q

YXJlc2lzL3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5TdHJva2UvY2xhc3NpZmlj

YXRpb24vKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPldhbGtpbmcvKmNsYXNzaWZp

Y2F0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1k

YXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAzLTk5OTM8

L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTgwNDc4OTA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxz

PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouYXBtci4yMDA3LjA3LjAzOTwvZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90

ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPgAAAA==

ADDIN EN.CITE.DATA [33, 41]. The accelerometers will be cleaned as per manufactures documented processes after each participant. The StepWatch monitor may be cleaned using a cloth dampened with mild soap and water or 70% isopropyl alcohol. The dock may be cleaned using a cloth dampened with mild soap and water or 70% isopropyl alcohol. The StepWatch straps may be hand washed with mild soap and water, or a solution of 70% isopropyl alcohol. ActiGraph devices are approved to be cleaned with a non-abrasive cloth and isopropyl alcohol for 15-20 seconds, and let air dry. Patient demographics and clinical detailsPatient demographic and clinical detailsAge, gender, date of hospital admission, date, type and side of stroke, past medical history, social situation and premorbid walking ability (FAC score). Initial NIHSS score in stroke patientsThe National Institute of Health Stroke Scale is routinely used within the ASU and measures severity of stroke. Stroke severity will be classified as mild NIHSS < 8, moderate NIHSS 8 to 16, severe NIHSS > 16.Oxfordshire Classification of StrokeThe Oxfordshire Classification is also known as the Bamford classification, and divides people with stroke into four different categories according to the clinical symptoms and signs with which they present. This classification is useful for understanding the likely underlying pathology, which in turn gives information on treatments which may be useful and the prognosis. It is a relatively simple, robust, bedside classification using clinical information. The easiest way to use the Bamford classification is to look for the presence or absence of the four main features of stroke - hemiparesis, higher cortical dysfunction (including language problems), hemi-anopia and brainstem signs. Once you have this information, you can classify your patient's stroke type: lacunar stroke (LACS), partial anterior circulation stroke (PACS), total anterior circulation stroke (TACS) or posterior circulation stroke (POCS)Functional Ambulation Category?Clinician-completed tick box of 6 broad categories of walking ability, ranges from independent walking outside to non-functional walking. Patients can be rated on the following?categories:0: Patient cannot walk, or needs help from 2 or more persons1: Patients needs firm continuous support from 1 person who helps carrying weight and with balance2: Patient needs continuous or intermittent support of one person to help with balance and coordination.3: Patient requires verbal supervision or stand-by help from one person without physical contact 4: Patient can walk independently on level ground, but requires help on stairs, slopes or uneven surfaces5: Patient can walk independently anywhereFunctional Independence Measure (FIM)Provides a uniform system of measurement for disability based on the?International Classification of Impairment, Disabilities and Handicaps; measures the level of a patient's disability and indicates how much assistance is required for the individual to carry out activities of daily living.Contains 18 items composed of: 13 motor tasks and 5 cognitive tasks (considered basic activities of daily living)Tasks are rated on a 7 point ordinal scale that ranges from total assistance (or complete dependence) to complete independence. Scores range from 18 (lowest) to 126 (highest) indicating level of function. Scores are generally rated at admission and dischargeDimensions?assessed include: Eating, Grooming, Bathing, Upper body dressing, Lower body, dressing, Toileting, Bladder management, Bowel management, Bed to chair transfer, Toilet, transfer, Shower transfer, Locomotion (ambulatory or wheelchair level), Stairs, Cognitive comprehension, Expression, Social interaction, Problem solving and MemoryHandheld DynamometerA handheld dynamometer will be used to assess strength of the ankle dorsiflexors and plantar flexors muscles and grip strength on both limbs. This is important because it will ensure that the strength levels of the muscle groups associated with gait capacity are comparable between the two cohorts of patients. Information to participants:PatientsIt will be explained to participants that we are observing activity levels of patients in the current Acute Stroke Unit in Nambour and in the Caloundra Rehabilitation Assessment Unit and that we will repeat observing activity levels in a similar cohort of patients in these units once they have transitioned to the new hospital facility.We will explain to participants that this study aims to determine activity levels while admitted to an Acute Stroke Unit and a Sub-Acute Rehabilitation Unit pre and post transition to a new hospital. We will inform participants that their participation will not influence the level of care provided while admitted. To gather information about their physical, social and cognitive activity levels with behavioral mapping the participants will be told they will be observed during one weekday and one weekend day of the same week from 8:00 am till 5:00 pm in 10-minute intervals. Participants will also be informed that physical activity levels will be monitored with accelerometers worn around the ankle (Stepwatches) and both wrists (Actigraph) for 3 consecutive days starting and finishing on the same days the behavioral mapping is to occur. Data analysis and end-points of the studyThe following outcome measurements will be obtained from patients at discharge from the studyPrimary Outcome Measures:Percentage time in total, physical, social and cognitive activities (BM)Proportion of day mobilizing (AM)Average steps per day (AM)Average sedentary time per day (AM)Average upper limb activity counts per day for each upper limb (AM)Secondary outcome measures: Observed activity in each subcategory by domain, position, location and people present (BM)Total activity levels weekday compared to weekend (BM)Average weekday steps per day compared to average weekend steps per day (AM)Physical activity by location with collation of behavioral mapping data and accelerometery dataAverage Hours Sleep per nightFor the primary outcome we will use one-way ANCOVA to determine difference in activity levels between groups adjusting for covariates of age in all participants and stroke severity (NIHSS) in stroke patients only. We will determine the difference in activity levels for ‘total activity’ and for the physical, social and cognitive activity domains. We will also determine total percentage time spent in different postural positions, location and people present with the participant. Consistent with previous research in this field, missing and unobserved data will be excluded from the statistical analysis for the primary outcome ADDIN EN.CITE <EndNote><Cite><Author>Janssen</Author><Year>2014</Year><RecNum>16</RecNum><DisplayText>[4]</DisplayText><record><rec-number>16</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1422013069">16</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Janssen, H.</author><author>Ada, L.</author><author>Bernhardt, J.</author><author>McElduff, P.</author><author>Pollack, M.</author><author>Nilsson, M.</author><author>Spratt, N. J.</author></authors></contributors><auth-address>University of Newcastle .</auth-address><titles><title>An enriched environment increases activity in stroke patients undergoing rehabilitation in a mixed rehabilitation unit: a pilot non-randomized controlled trial</title><secondary-title>Disabil Rehabil</secondary-title><alt-title>Disability and rehabilitation</alt-title></titles><periodical><full-title>Disabil Rehabil</full-title><abbr-1>Disability and rehabilitation</abbr-1></periodical><alt-periodical><full-title>Disabil Rehabil</full-title><abbr-1>Disability and rehabilitation</abbr-1></alt-periodical><pages>255-62</pages><volume>36</volume><number>3</number><edition>2013/05/01</edition><keywords><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Leisure Activities</keyword><keyword>Male</keyword><keyword>*Motor Activity</keyword><keyword>Pilot Projects</keyword><keyword>Prospective Studies</keyword><keyword>Stroke/*rehabilitation</keyword></keywords><dates><year>2014</year></dates><isbn>0963-8288</isbn><accession-num>23627534</accession-num><urls></urls><electronic-resource-num>10.3109/09638288.2013.788218</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[4].We will analyze percentage observed total, physical, social and cognitive activity shown in participants occupying single, two or multiple bedrooms while present in their hospital room pre and post transition. We will also determine percentage observed total, physical, social and cognitive activity shown in communal and outdoor areas pre and post transition.Activity data from the accelerometer will be analyzed using the proprietary software or established algorithms for identifying outcome measures implemented in custom written software. This will consist of loading the raw data into the software and extracting the steps per day (Stepwatch) or arm movements (Actigraph), along with the duration of intervals per day in which no steps or arm movements are recorded. These data will then be averaged across the three days to obtain the average score per day for that patient. Benefits / significance / outcomesDespite significant evidence regarding benefits of physical, social and cognitive activity in acute stroke and rehabilitation patients, little is known about how the layout of a hospital affects activity patterns. This study willContribute to knowledge of how the physical environment impacts activity levels within different hospital designsProvide a baseline from which the effects of subsequent changes in model of care / environment can be measured Provide new knowledge regarding current activity levels in inpatient rehabilitationEmbed monitoring of activity into usual practice within acute stroke and rehabilitation settings Lay the foundation for future research into mechanisms to alter activity levels within hospital patients Hospital design has moved in the last decade towards a single bedroom design as evidence is indicating the beneficial effects of single rooms on infection control and reduced medication errors. Another major factor impacting on patient recovery is activity PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZWVyYmVlazwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTEsIDQyXTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9InMyZjBmejBhb3N0dGZpZXhmOWx4MDlkNDkydHRkdmZ3MmYwciIgdGltZXN0YW1w

PSIxNDIyMDA3MjI5Ij4xMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

VmVlcmJlZWssIEouIE0uPC9hdXRob3I+PGF1dGhvcj52YW4gV2VnZW4sIEUuPC9hdXRob3I+PGF1

dGhvcj52YW4gUGVwcGVuLCBSLjwvYXV0aG9yPjxhdXRob3I+dmFuIGRlciBXZWVzLCBQLiBKLjwv

YXV0aG9yPjxhdXRob3I+SGVuZHJpa3MsIEUuPC9hdXRob3I+PGF1dGhvcj5SaWV0YmVyZywgTS48

L2F1dGhvcj48YXV0aG9yPkt3YWtrZWwsIEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBSZWhhYmlsaXRhdGlvbiBNZWRpY2luZSwg

TU9WRSBSZXNlYXJjaCBJbnN0aXR1dGUgQW1zdGVyZGFtLCBWVSBVbml2ZXJzaXR5IE1lZGljYWwg

Q2VudGVyLCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQgb2YgUGh5

c2lvdGhlcmFweSwgVW5pdmVyc2l0eSBvZiBBcHBsaWVkIFNjaWVuY2VzIFV0cmVjaHQsIFV0cmVj

aHQsIFRoZSBOZXRoZXJsYW5kcy4mI3hEO1NjaWVudGlmaWMgSW5zdGl0dXRlIGZvciBRdWFsaXR5

IG9mIEhlYWx0aGNhcmUgKElRIGhlYWx0aGNhcmUpLCBSYWRib3VkIFVuaXZlcnNpdHkgTmlqbWVn

ZW4gTWVkaWNhbCBDZW50ZXIsIE5pam1lZ2VuLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRt

ZW50IG9mIEVwaWRlbWlvbG9neSwgTWFhc3RyaWNodCBVbml2ZXJzaXR5LCBNYWFzdHJpY2h0LCBU

aGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9mIFJlaGFiaWxpdGF0aW9uIE1lZGljaW5l

LCBNT1ZFIFJlc2VhcmNoIEluc3RpdHV0ZSBBbXN0ZXJkYW0sIFZVIFVuaXZlcnNpdHkgTWVkaWNh

bCBDZW50ZXIsIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzIDsgRGVwYXJ0bWVudCBvZiBOZXVy

b3JlaGFiaWxpdGF0aW9uLCBSZWFkZSBDZW50ZXIgZm9yIFJlaGFiaWxpdGF0aW9uIGFuZCBSaGV1

bWF0b2xvZ3ksIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzLjwvYXV0aC1hZGRyZXNzPjx0aXRs

ZXM+PHRpdGxlPldoYXQgaXMgdGhlIGV2aWRlbmNlIGZvciBwaHlzaWNhbCB0aGVyYXB5IHBvc3Rz

dHJva2U/IEEgc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+UExvUyBPbmU8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBsb1Mgb25l

PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UExvUyBPbmU8L2Z1

bGwtdGl0bGU+PGFiYnItMT5QbG9TIG9uZTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+UExvUyBPbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5QbG9TIG9uZTwv

YWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmU4Nzk4NzwvcGFnZXM+PHZvbHVtZT45PC92

b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxNC8wMi8wODwvZWRpdGlvbj48a2V5

d29yZHM+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk11c2NsZSBTdHJlbmd0aC9w

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPipQaHlzaWNhbCBUaGVyYXB5IE1vZGFsaXRpZXM8

L2tleXdvcmQ+PGtleXdvcmQ+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFscyBhcyBUb3BpYzwv

a2V5d29yZD48a2V5d29yZD5TdHJva2UvcGh5c2lvcGF0aG9sb2d5LypyZWhhYmlsaXRhdGlvbjwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PGlzYm4+

MTkzMi02MjAzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NTA1MzQyPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48Y3VzdG9tMj5QbWMzOTEzNzg2PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMzcxL2pvdXJuYWwucG9uZS4wMDg3OTg3PC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3Zp

ZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PkdvdmFuPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjIyPC9SZWNOdW0+PHJlY29y

ZD48cmVjLW51bWJlcj4yMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9InMyZjBmejBhb3N0dGZpZXhmOWx4MDlkNDkydHRkdmZ3MmYwciIgdGltZXN0YW1wPSIx

NDIyMTQwMzc5Ij4yMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R292

YW4sIEwuPC9hdXRob3I+PGF1dGhvcj5MYW5naG9ybmUsIFAuPC9hdXRob3I+PGF1dGhvcj5XZWly

LCBDLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkFj

YWRlbWljIFNlY3Rpb24gb2YgR2VyaWF0cmljIE1lZGljaW5lLCBVbml2ZXJzaXR5IEJsb2NrLCBH

bGFzZ293IFJveWFsIEluZmlybWFyeSwgR2xhc2dvdywgVUsuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RG9lcyB0aGUgcHJldmVudGlvbiBvZiBjb21wbGljYXRpb25zIGV4cGxhaW4gdGhl

IHN1cnZpdmFsIGJlbmVmaXQgb2Ygb3JnYW5pemVkIGlucGF0aWVudCAoc3Ryb2tlIHVuaXQpIGNh

cmU/OiBmdXJ0aGVyIGFuYWx5c2lzIG9mIGEgc3lzdGVtYXRpYyByZXZpZXc8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEg

am91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVsbC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBq

b3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7

IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGlj

YWw+PHBhZ2VzPjI1MzYtNDA8L3BhZ2VzPjx2b2x1bWU+Mzg8L3ZvbHVtZT48bnVtYmVyPjk8L251

bWJlcj48ZWRpdGlvbj4yMDA3LzA4LzExPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qSG9z

cGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxpemF0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5wYXRpZW50czwva2V5d29yZD48a2V5

d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3

b3JkPipTdHJva2UvY29tcGxpY2F0aW9ucy9tb3J0YWxpdHkvdGhlcmFweTwva2V5d29yZD48a2V5

d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29t

ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA3PC95ZWFyPjxwdWItZGF0ZXM+

PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjE3NjkwMzEzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE2MS9zdHJva2VhaGEuMTA2LjQ3ODg0MjwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPgAA

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZWVyYmVlazwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTEsIDQyXTwvRGlzcGxheVRleHQ+PHJl

Y29yZD48cmVjLW51bWJlcj4xMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9InMyZjBmejBhb3N0dGZpZXhmOWx4MDlkNDkydHRkdmZ3MmYwciIgdGltZXN0YW1w

PSIxNDIyMDA3MjI5Ij4xMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy

bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+

VmVlcmJlZWssIEouIE0uPC9hdXRob3I+PGF1dGhvcj52YW4gV2VnZW4sIEUuPC9hdXRob3I+PGF1

dGhvcj52YW4gUGVwcGVuLCBSLjwvYXV0aG9yPjxhdXRob3I+dmFuIGRlciBXZWVzLCBQLiBKLjwv

YXV0aG9yPjxhdXRob3I+SGVuZHJpa3MsIEUuPC9hdXRob3I+PGF1dGhvcj5SaWV0YmVyZywgTS48

L2F1dGhvcj48YXV0aG9yPkt3YWtrZWwsIEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0

b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBSZWhhYmlsaXRhdGlvbiBNZWRpY2luZSwg

TU9WRSBSZXNlYXJjaCBJbnN0aXR1dGUgQW1zdGVyZGFtLCBWVSBVbml2ZXJzaXR5IE1lZGljYWwg

Q2VudGVyLCBBbXN0ZXJkYW0sIFRoZSBOZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQgb2YgUGh5

c2lvdGhlcmFweSwgVW5pdmVyc2l0eSBvZiBBcHBsaWVkIFNjaWVuY2VzIFV0cmVjaHQsIFV0cmVj

aHQsIFRoZSBOZXRoZXJsYW5kcy4mI3hEO1NjaWVudGlmaWMgSW5zdGl0dXRlIGZvciBRdWFsaXR5

IG9mIEhlYWx0aGNhcmUgKElRIGhlYWx0aGNhcmUpLCBSYWRib3VkIFVuaXZlcnNpdHkgTmlqbWVn

ZW4gTWVkaWNhbCBDZW50ZXIsIE5pam1lZ2VuLCBUaGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRt

ZW50IG9mIEVwaWRlbWlvbG9neSwgTWFhc3RyaWNodCBVbml2ZXJzaXR5LCBNYWFzdHJpY2h0LCBU

aGUgTmV0aGVybGFuZHMuJiN4RDtEZXBhcnRtZW50IG9mIFJlaGFiaWxpdGF0aW9uIE1lZGljaW5l

LCBNT1ZFIFJlc2VhcmNoIEluc3RpdHV0ZSBBbXN0ZXJkYW0sIFZVIFVuaXZlcnNpdHkgTWVkaWNh

bCBDZW50ZXIsIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzIDsgRGVwYXJ0bWVudCBvZiBOZXVy

b3JlaGFiaWxpdGF0aW9uLCBSZWFkZSBDZW50ZXIgZm9yIFJlaGFiaWxpdGF0aW9uIGFuZCBSaGV1

bWF0b2xvZ3ksIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzLjwvYXV0aC1hZGRyZXNzPjx0aXRs

ZXM+PHRpdGxlPldoYXQgaXMgdGhlIGV2aWRlbmNlIGZvciBwaHlzaWNhbCB0aGVyYXB5IHBvc3Rz

dHJva2U/IEEgc3lzdGVtYXRpYyByZXZpZXcgYW5kIG1ldGEtYW5hbHlzaXM8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+UExvUyBPbmU8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBsb1Mgb25l

PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+UExvUyBPbmU8L2Z1

bGwtdGl0bGU+PGFiYnItMT5QbG9TIG9uZTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv

ZGljYWw+PGZ1bGwtdGl0bGU+UExvUyBPbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5QbG9TIG9uZTwv

YWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmU4Nzk4NzwvcGFnZXM+PHZvbHVtZT45PC92

b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxNC8wMi8wODwvZWRpdGlvbj48a2V5

d29yZHM+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk11c2NsZSBTdHJlbmd0aC9w

aHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPipQaHlzaWNhbCBUaGVyYXB5IE1vZGFsaXRpZXM8

L2tleXdvcmQ+PGtleXdvcmQ+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFscyBhcyBUb3BpYzwv

a2V5d29yZD48a2V5d29yZD5TdHJva2UvcGh5c2lvcGF0aG9sb2d5LypyZWhhYmlsaXRhdGlvbjwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjwvZGF0ZXM+PGlzYm4+

MTkzMi02MjAzPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NTA1MzQyPC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48Y3VzdG9tMj5QbWMzOTEzNzg2PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMzcxL2pvdXJuYWwucG9uZS4wMDg3OTg3PC9lbGVjdHJvbmljLXJlc291cmNl

LW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3Zp

ZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9y

PkdvdmFuPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjIyPC9SZWNOdW0+PHJlY29y

ZD48cmVjLW51bWJlcj4yMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9InMyZjBmejBhb3N0dGZpZXhmOWx4MDlkNDkydHRkdmZ3MmYwciIgdGltZXN0YW1wPSIx

NDIyMTQwMzc5Ij4yMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R292

YW4sIEwuPC9hdXRob3I+PGF1dGhvcj5MYW5naG9ybmUsIFAuPC9hdXRob3I+PGF1dGhvcj5XZWly

LCBDLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkFj

YWRlbWljIFNlY3Rpb24gb2YgR2VyaWF0cmljIE1lZGljaW5lLCBVbml2ZXJzaXR5IEJsb2NrLCBH

bGFzZ293IFJveWFsIEluZmlybWFyeSwgR2xhc2dvdywgVUsuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+RG9lcyB0aGUgcHJldmVudGlvbiBvZiBjb21wbGljYXRpb25zIGV4cGxhaW4gdGhl

IHN1cnZpdmFsIGJlbmVmaXQgb2Ygb3JnYW5pemVkIGlucGF0aWVudCAoc3Ryb2tlIHVuaXQpIGNh

cmU/OiBmdXJ0aGVyIGFuYWx5c2lzIG9mIGEgc3lzdGVtYXRpYyByZXZpZXc8L3RpdGxlPjxzZWNv

bmRhcnktdGl0bGU+U3Ryb2tlPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5TdHJva2U7IGEg

am91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPlN0cm9rZTwvZnVsbC10aXRsZT48YWJici0xPlN0cm9rZTsgYSBq

b3VybmFsIG9mIGNlcmVicmFsIGNpcmN1bGF0aW9uPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt

cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TdHJva2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5TdHJva2U7

IGEgam91cm5hbCBvZiBjZXJlYnJhbCBjaXJjdWxhdGlvbjwvYWJici0xPjwvYWx0LXBlcmlvZGlj

YWw+PHBhZ2VzPjI1MzYtNDA8L3BhZ2VzPjx2b2x1bWU+Mzg8L3ZvbHVtZT48bnVtYmVyPjk8L251

bWJlcj48ZWRpdGlvbj4yMDA3LzA4LzExPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD4qSG9z

cGl0YWwgVW5pdHM8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxpemF0aW9uPC9rZXl3b3JkPjxr

ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5wYXRpZW50czwva2V5d29yZD48a2V5

d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3

b3JkPipTdHJva2UvY29tcGxpY2F0aW9ucy9tb3J0YWxpdHkvdGhlcmFweTwva2V5d29yZD48a2V5

d29yZD5TdXJ2aXZhbCBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29t

ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA3PC95ZWFyPjxwdWItZGF0ZXM+

PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAzOS0yNDk5PC9pc2Ju

PjxhY2Nlc3Npb24tbnVtPjE3NjkwMzEzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48ZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE2MS9zdHJva2VhaGEuMTA2LjQ3ODg0MjwvZWxlY3Ry

b25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+

PC9FbmROb3RlPgAA

ADDIN EN.CITE.DATA [11, 42] as it enhances recovery PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZWVyYmVlazwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTFdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iczJmMGZ6MGFvc3R0ZmlleGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1lc3RhbXA9IjE0

MjIwMDcyMjkiPjEwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WZWVy

YmVlaywgSi4gTS48L2F1dGhvcj48YXV0aG9yPnZhbiBXZWdlbiwgRS48L2F1dGhvcj48YXV0aG9y

PnZhbiBQZXBwZW4sIFIuPC9hdXRob3I+PGF1dGhvcj52YW4gZGVyIFdlZXMsIFAuIEouPC9hdXRo

b3I+PGF1dGhvcj5IZW5kcmlrcywgRS48L2F1dGhvcj48YXV0aG9yPlJpZXRiZXJnLCBNLjwvYXV0

aG9yPjxhdXRob3I+S3dha2tlbCwgRy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJlaGFiaWxpdGF0aW9uIE1lZGljaW5lLCBNT1ZF

IFJlc2VhcmNoIEluc3RpdHV0ZSBBbXN0ZXJkYW0sIFZVIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50

ZXIsIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBQaHlzaW90

aGVyYXB5LCBVbml2ZXJzaXR5IG9mIEFwcGxpZWQgU2NpZW5jZXMgVXRyZWNodCwgVXRyZWNodCwg

VGhlIE5ldGhlcmxhbmRzLiYjeEQ7U2NpZW50aWZpYyBJbnN0aXR1dGUgZm9yIFF1YWxpdHkgb2Yg

SGVhbHRoY2FyZSAoSVEgaGVhbHRoY2FyZSksIFJhZGJvdWQgVW5pdmVyc2l0eSBOaWptZWdlbiBN

ZWRpY2FsIENlbnRlciwgTmlqbWVnZW4sIFRoZSBOZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQg

b2YgRXBpZGVtaW9sb2d5LCBNYWFzdHJpY2h0IFVuaXZlcnNpdHksIE1hYXN0cmljaHQsIFRoZSBO

ZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQgb2YgUmVoYWJpbGl0YXRpb24gTWVkaWNpbmUsIE1P

VkUgUmVzZWFyY2ggSW5zdGl0dXRlIEFtc3RlcmRhbSwgVlUgVW5pdmVyc2l0eSBNZWRpY2FsIENl

bnRlciwgQW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMgOyBEZXBhcnRtZW50IG9mIE5ldXJvcmVo

YWJpbGl0YXRpb24sIFJlYWRlIENlbnRlciBmb3IgUmVoYWJpbGl0YXRpb24gYW5kIFJoZXVtYXRv

bG9neSwgQW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+V2hhdCBpcyB0aGUgZXZpZGVuY2UgZm9yIHBoeXNpY2FsIHRoZXJhcHkgcG9zdHN0cm9r

ZT8gQSBzeXN0ZW1hdGljIHJldmlldyBhbmQgbWV0YS1hbmFseXNpczwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5QTG9TIE9uZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UGxvUyBvbmU8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIE9uZTwvZnVsbC10

aXRsZT48YWJici0xPlBsb1Mgb25lPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5QTG9TIE9uZTwvZnVsbC10aXRsZT48YWJici0xPlBsb1Mgb25lPC9hYmJy

LTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+ZTg3OTg3PC9wYWdlcz48dm9sdW1lPjk8L3ZvbHVt

ZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDE0LzAyLzA4PC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TXVzY2xlIFN0cmVuZ3RoL3BoeXNp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+KlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllczwva2V5

d29yZD48a2V5d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3

b3JkPjxrZXl3b3JkPlN0cm9rZS9waHlzaW9wYXRob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48aXNibj4xOTMy

LTYyMDM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQ1MDUzNDI8L2FjY2Vzc2lvbi1udW0+PHVybHM+

PC91cmxzPjxjdXN0b20yPlBtYzM5MTM3ODY8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjEwLjEzNzEvam91cm5hbC5wb25lLjAwODc5ODc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+

PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4AAD==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5WZWVyYmVlazwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+

PFJlY051bT4xMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTFdPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjEwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iczJmMGZ6MGFvc3R0ZmlleGY5bHgwOWQ0OTJ0dGR2ZncyZjByIiB0aW1lc3RhbXA9IjE0

MjIwMDcyMjkiPjEwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5WZWVy

YmVlaywgSi4gTS48L2F1dGhvcj48YXV0aG9yPnZhbiBXZWdlbiwgRS48L2F1dGhvcj48YXV0aG9y

PnZhbiBQZXBwZW4sIFIuPC9hdXRob3I+PGF1dGhvcj52YW4gZGVyIFdlZXMsIFAuIEouPC9hdXRo

b3I+PGF1dGhvcj5IZW5kcmlrcywgRS48L2F1dGhvcj48YXV0aG9yPlJpZXRiZXJnLCBNLjwvYXV0

aG9yPjxhdXRob3I+S3dha2tlbCwgRy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFJlaGFiaWxpdGF0aW9uIE1lZGljaW5lLCBNT1ZF

IFJlc2VhcmNoIEluc3RpdHV0ZSBBbXN0ZXJkYW0sIFZVIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50

ZXIsIEFtc3RlcmRhbSwgVGhlIE5ldGhlcmxhbmRzLiYjeEQ7RGVwYXJ0bWVudCBvZiBQaHlzaW90

aGVyYXB5LCBVbml2ZXJzaXR5IG9mIEFwcGxpZWQgU2NpZW5jZXMgVXRyZWNodCwgVXRyZWNodCwg

VGhlIE5ldGhlcmxhbmRzLiYjeEQ7U2NpZW50aWZpYyBJbnN0aXR1dGUgZm9yIFF1YWxpdHkgb2Yg

SGVhbHRoY2FyZSAoSVEgaGVhbHRoY2FyZSksIFJhZGJvdWQgVW5pdmVyc2l0eSBOaWptZWdlbiBN

ZWRpY2FsIENlbnRlciwgTmlqbWVnZW4sIFRoZSBOZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQg

b2YgRXBpZGVtaW9sb2d5LCBNYWFzdHJpY2h0IFVuaXZlcnNpdHksIE1hYXN0cmljaHQsIFRoZSBO

ZXRoZXJsYW5kcy4mI3hEO0RlcGFydG1lbnQgb2YgUmVoYWJpbGl0YXRpb24gTWVkaWNpbmUsIE1P

VkUgUmVzZWFyY2ggSW5zdGl0dXRlIEFtc3RlcmRhbSwgVlUgVW5pdmVyc2l0eSBNZWRpY2FsIENl

bnRlciwgQW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMgOyBEZXBhcnRtZW50IG9mIE5ldXJvcmVo

YWJpbGl0YXRpb24sIFJlYWRlIENlbnRlciBmb3IgUmVoYWJpbGl0YXRpb24gYW5kIFJoZXVtYXRv

bG9neSwgQW1zdGVyZGFtLCBUaGUgTmV0aGVybGFuZHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48

dGl0bGU+V2hhdCBpcyB0aGUgZXZpZGVuY2UgZm9yIHBoeXNpY2FsIHRoZXJhcHkgcG9zdHN0cm9r

ZT8gQSBzeXN0ZW1hdGljIHJldmlldyBhbmQgbWV0YS1hbmFseXNpczwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5QTG9TIE9uZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UGxvUyBvbmU8L2Fs

dC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIE9uZTwvZnVsbC10

aXRsZT48YWJici0xPlBsb1Mgb25lPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5QTG9TIE9uZTwvZnVsbC10aXRsZT48YWJici0xPlBsb1Mgb25lPC9hYmJy

LTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+ZTg3OTg3PC9wYWdlcz48dm9sdW1lPjk8L3ZvbHVt

ZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDE0LzAyLzA4PC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TXVzY2xlIFN0cmVuZ3RoL3BoeXNp

b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+KlBoeXNpY2FsIFRoZXJhcHkgTW9kYWxpdGllczwva2V5

d29yZD48a2V5d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3

b3JkPjxrZXl3b3JkPlN0cm9rZS9waHlzaW9wYXRob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PC9kYXRlcz48aXNibj4xOTMy

LTYyMDM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQ1MDUzNDI8L2FjY2Vzc2lvbi1udW0+PHVybHM+

PC91cmxzPjxjdXN0b20yPlBtYzM5MTM3ODY8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjEwLjEzNzEvam91cm5hbC5wb25lLjAwODc5ODc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt

PjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+

PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4AAD==

ADDIN EN.CITE.DATA [11] and prevents secondary complications ADDIN EN.CITE <EndNote><Cite><Author>Govan</Author><Year>2007</Year><RecNum>22</RecNum><DisplayText>[42]</DisplayText><record><rec-number>22</rec-number><foreign-keys><key app="EN" db-id="s2f0fz0aosttfiexf9lx09d492ttdvfw2f0r" timestamp="1422140379">22</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Govan, L.</author><author>Langhorne, P.</author><author>Weir, C. J.</author></authors></contributors><auth-address>Academic Section of Geriatric Medicine, University Block, Glasgow Royal Infirmary, Glasgow, UK.</auth-address><titles><title>Does the prevention of complications explain the survival benefit of organized inpatient (stroke unit) care?: further analysis of a systematic review</title><secondary-title>Stroke</secondary-title><alt-title>Stroke; a journal of cerebral circulation</alt-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><alt-periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></alt-periodical><pages>2536-40</pages><volume>38</volume><number>9</number><edition>2007/08/11</edition><keywords><keyword>*Hospital Units</keyword><keyword>Hospitalization</keyword><keyword>Humans</keyword><keyword>*Inpatients</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>*Stroke/complications/mortality/therapy</keyword><keyword>Survival Analysis</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2007</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0039-2499</isbn><accession-num>17690313</accession-num><urls></urls><electronic-resource-num>10.1161/strokeaha.106.478842</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[42]. This study will be a first in contributing to new knowledge quantifying if patient activity alters in single versus multiple bedrooms and how communal and outdoor areas impact on activity levels in patients. The study will therefore provide direction for future developments in hospital design. Tracking activity data at the same time as behavioral mapping will enable the validation of activity tracking within acute and sub-acute rehabilitation settings. These data can then be used to validate innovative technologies of activity monitoring in future research while building collaborative networks with University of the Sunshine Coast. The dose, frequency and timing of therapy and its relationship to functional outcomes is a rapidly expanding area within neurological rehabilitation. These metrics of training have been, and continue to be, extensively studied in the able bodied population in efforts to optimize performance. The burden on our health care system is set to increase significantly in the coming years and considerable research is required to ensure effective and efficient therapy is provided within acute and sub-acute rehabilitation services. By embedding the use of technology and the building of collaborative networks with the University of the Sunshine Coast, our hospital and health service is set to lead the development of interventions that may guide national and international therapy interventions.References ADDIN EN.REFLIST 1.West, T. and J. Bernhardt, Physical activity in hospitalised stroke patients. Stroke Res Treat, 2012. 2012: p. 813765.2.De Wit, L., et al., Use of time by stroke patients: a comparison of four European rehabilitation centers. Stroke, 2005. 36(9): p. 1977-83.3.Bernhardt, J., et al., Not all stroke units are the same: a comparison of physical activity patterns in Melbourne, Australia, and Trondheim, Norway. Stroke, 2008. 39(7): p. 2059-65.4.Janssen, H., et al., An enriched environment increases activity in stroke patients undergoing rehabilitation in a mixed rehabilitation unit: a pilot non-randomized controlled trial. Disabil Rehabil, 2014. 36(3): p. 255-62.5.Wright, L., et al., Stroke management: updated recommendations for treatment along the care continuum. Intern Med J, 2012. 42(5): p. 562-9.6.NICE. Stroke Rehabilitation: therapy. 2013 [cited 2016 1 feb]; Available from: , E., et al., The learned nonuse phenomenon: implications for rehabilitation. Eura Medicophys, 2006. 42(3): p. 241-56.8.Shepherd, R.B., Exercise and training to optimize functional motor performance in stroke: driving neural reorganization? Neural Plast, 2001. 8(1-2): p. 121-9.9.Teasell, R., et al., Evidence-Based Review of Stroke Rehabilitation: executive summary, 12th edition. Top Stroke Rehabil, 2009. 16(6): p. 463-88.10.French, B., et al., Repetitive task training for improving functional ability after stroke. Cochrane Database Syst Rev, 2007(4): p. Cd006073.11.Veerbeek, J.M., et al., What is the evidence for physical therapy poststroke? A systematic review and meta-analysis. PLoS One, 2014. 9(2): p. e87987.12.Kruithof, W.J., et al., Associations between social support and stroke survivors' health-related quality of life--a systematic review. Patient Educ Couns, 2013. 93(2): p. 169-76.13.Warner, E.L., et al., Social well-being among adolescents and young adults with cancer: A systematic review. Cancer, 2016. 122(7): p. 1029-37.14.Sirri, L., C. Magelli, and S. Grandi, Predictors of perceived social support in long-term survivors of cardiac transplant: the role of psychological distress, quality of life, demographic characteristics and clinical course. Psychol Health, 2011. 26(1): p. 77-94.15.Glass, T.A., et al., Impact of social support on outcome in first stroke. Stroke, 1993. 24(1): p. 64-70.16.Tsouna-Hadjis, E., et al., First-stroke recovery process: the role of family social support. Arch Phys Med Rehabil, 2000. 81(7): p. 881-7.17.Harris, J.E., et al., The role of caregiver involvement in upper-limb treatment in individuals with subacute stroke. Phys Ther, 2010. 90(9): p. 1302-10.18.Sarkamo, T., et al., Music listening enhances cognitive recovery and mood after middle cerebral artery stroke. Brain, 2008. 131(Pt 3): p. 866-76.19.Tsai, P.L., et al., Listening to classical music ameliorates unilateral neglect after stroke. Am J Occup Ther, 2013. 67(3): p. 328-35.20.Sarkamo, T., et al., Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study. Front Hum Neurosci, 2014. 8: p. 245.21.Ulrich, R.S., et al., A review of the research literature on evidence-based healthcare design. Herd, 2008. 1(3): p. 61-125.22.Pennington, H. and C. Isles, Should hospitals provide all patients with single rooms? Bmj, 2013. 347: p. f5695.23.Pangrazio, J.R., Room with a view. Looking at the future of patient room design. Health Facil Manage, 2003. 16(12): p. 30-2.24.Clancy, C.M., Designing for safety: evidence-based design and hospitals. Am J Med Qual, 2008. 23(1): p. 66-9.25.Design, W.H. Patient Safety: Single-bed versus multi-bed hospital rooms. 2014 [cited 2016; Available from: , C., P. Glasziou, and C. Del Mar, Bed rest: a potentially harmful treatment needing more careful evaluation. Lancet, 1999. 354(9186): p. 1229-33.27.Browall, M., et al., Patients' experience of important factors in the healthcare environment in oncology care. Int J Qual Stud Health Well-being, 2013. 8: p. 20870.28.James, P., et al., A Review of the Health Benefits of Greenness. Curr Epidemiol Rep, 2015. 2(2): p. 131-142.29."Ming" Kuo, F., Nature-deficit disorder: Evidence, dosage and treatment. Journal of Policy Research in Tourism, leisure and Events, 2013. 5: p. 172-86.30.Mackey, F., et al., Stroke rehabilitation: are highly structured units more conducive to physical activity than less structured units? Arch Phys Med Rehabil, 1996. 77(10): p. 1066-70.31.Bernhardt, J., et al., Inactive and alone: physical activity within the first 14 days of acute stroke unit care. Stroke, 2004. 35(4): p. 1005-9.32.Uswatte, G., et al., Objective measurement of functional upper-extremity movement using accelerometer recordings transformed with a threshold filter. Stroke, 2000. 31(3): p. 662-7.33.Hayward, K.S., et al., Exploring the Role of Accelerometers in the Measurement of Real World Upper-Limb Use After Stroke. Brain Impairment, 2016. 17(Special Issue 01): p. 16-33.34.Bailey, R.R., J.W. Klaesner, and C.E. Lang, Quantifying Real-World Upper-Limb Activity in Nondisabled Adults and Adults With Chronic Stroke. Neurorehabil Neural Repair, 2015. 29(10): p. 969-78.35.Kwakkel, G., et al., Effects of augmented exercise therapy time after stroke: a meta-analysis. Stroke, 2004. 35(11): p. 2529-39.36.AROC, 2015 Caloundra Outcomes Benchmark Report, A.R.O. Collaborative, Editor. 2015. p. 1-146.37.Janssen, H., et al., Translating the use of an enriched environment poststroke from bench to bedside: study design and protocol used to test the feasibility of environmental enrichment on stroke patients in rehabilitation. Int J Stroke, 2012. 7(6): p. 521-6.38.Lang, C.E., et al., Observation of amounts of movement practice provided during stroke rehabilitation. Arch Phys Med Rehabil, 2009. 90(10): p. 1692-8.39.Tole, G., et al., An observational study on usual physiotherapy care in a stroke rehabilitation unit for patients with mobility deficits. International Journal of Therapy and Rehabilitation, 2014. 21(12): p. 585-589.40.Martin, J.L. and A.D. Hakim, Wrist actigraphy. Chest, 2011. 139(6): p. 1514-27.41.Mudge, S., N.S. Stott, and S.E. Walt, Criterion validity of the StepWatch Activity Monitor as a measure of walking activity in patients after stroke. Arch Phys Med Rehabil, 2007. 88(12): p. 1710-5.an, L., P. Langhorne, and C.J. Weir, Does the prevention of complications explain the survival benefit of organized inpatient (stroke unit) care?: further analysis of a systematic review. Stroke, 2007. 38(9): p. 2536-40. ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download