Possible Side Effects of PEG L-asparaginase and …



Possible Side Effects of PEG L-asparaginase and Vincristine (Table Version Date: August 28, 2014)

|COMMON, SOME MAY BE SERIOUS |

|In 100 people receiving PEG L-asparaginase and Vincristine, more than 20 and up to 100 may have: |

|Nausea, vomiting |

|Chills, fever |

|Pain |

|Swelling of the body |

|Tiredness |

|Blockage of the airway which may cause cough, wheezing |

|Hives, rash |

|Constipation |

|Hair loss |

|Pain or redness at the site of injection |

|Numbness and tingling of fingers or toes |

|Headache, jaw pain and/or muscle pain |

|Weakness and difficulty walking |

|Swelling of lower legs |

|Diabetes |

|OCCASIONAL, SOME MAY BE SERIOUS |

|In 100 people receiving PEG L-asparaginase and Vincristine, from 4 to 20 may have: |

| Liver damage which may cause yellowing of eyes and skin |

|Anemia which may cause tiredness, or may require blood transfusions |

|Infection, especially when white blood cell count is low |

|Abnormal heart beat |

|Bruising, bleeding |

|Night sweats |

|Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat |

|Drooping eyelids |

|Hoarseness |

|RARE, AND SERIOUS |

|In 100 people receiving PEG L-asparaginase and Vincristine, 3 or fewer may have: |

|Blood clot |

|Damage to the pancreas |

|Seizure |

|Bleeding in the brain |

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