CTLA-4 up-regulation of lymphocyte function- associated ...
sionasobservedin CTLA-4 / vs.CTLA-4 / Tcells.Theseeffects were mediated by Rap-1 where anti-CTLA-4 activated the G protein, inactive Rap-1-N17 reversed adhesion and active Rap-1-V12 could substitute for the coreceptor. The role of CTLA-4 in LFA-1 clustering adhesion provides a novel pathway by which the coreceptor can modulate T cell immunity. ................
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