VASCULITIS ACOI 2018 - American College of Osteopathic Internists
VASCULITIS ACOI 2018
Robert L. DiGiovanni, DO, FACOI robdsimc@tampabay.
Disclosures
? NONE
Vasculitis
? Clinicopathologic process characterized by inflammation of and damage to blood vessels.
? Vessel lumen is usually compromised leading to possible ischemia and necrosis.
? This also leads to increased cytokine production and inflammation.
? Can be confined to one single organ (i.e skin), or it may simultaneously involve several organ systems.
? The distribution of affected organs may suggest a particular vasculitic disorder, but significant overlap is observed.
? It is often a serious and sometimes fatal disease that requires prompt recognition and therapy
Pathophysiology
? Multi-factorial:
? Genetic predisposition ? Environmental exposure ? Regulatory mechanisms associated with
immune response to certain antigens
Conditions that can mimic vasculitis
Infectious ds: ? Bacterial endocarditis ? Disseminated gonoccocal infection ? Pulmonary histoplasmosis ? Coccidioidomycosis ? Syphillis ? Lyme ds ? Rocky Mountain spotted fever ? Whipple's ds Coagulopathies/thrombotic microangiopathies ? Antiphosphlipid antibody syndrome ? Thrombotic thrombocytopenic purpura
?
Neoplasms Atrial myxoma Lymphoma Carcinomatosis
Drug toxicity Cocaine Amphetamines Ergot alkaloids Arsenic
Sarcoidosis Atheroembolic ds Goodpasture's syndrome Amyloidosis Migraine
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