University of Edinburgh
Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagenRany M. Salem1*, Jennifer N. Todd2, 3, 4*, Niina Sandholm5, 6, 7*, Joanne B. Cole2, 3, 4*, Wei-Min Chen8, Darrel Andrews9, Marcus G. Pezzolesi10, Paul M. McKeigue11, Linda T. Hiraki12, Chengxiang Qiu13, Viji Nair14, Chen Di Liao12, Jing Jing Cao12, Erkka Valo5, 6, 7, Suna Onengut-Gumuscu8, Adam M. Smiles15, Stuart J. McGurnaghan16, Jani K. Haukka5, 6, 7, Valma Harjutsalo5, 6, 7,17, Eoin P. Brennan9, Natalie van Zuydam18, 19, Emma Ahlqvist20, Ross Doyle9, Tarunveer S. Ahluwalia21, Maria Lajer21, Maria F. Hughes9, Jihwan Park13, Jan Skupien15, Athina Spiliopoulou11, Andrew Liu22, Rajasree Menon14, 23, Carine M. Boustany-Kari24, Hyun M. Kang23, 25, Robert G. Nelson26, Ronald Klein27, Barbara E. Klein27, Kristine E. Lee27, Xiaoyu Gao28, Michael Mauer29, Silvia Maeastroni30, Maria Luiza Caramori29, Ian H. de Boer31, Rachel G. Miller32, Jingchuan Guo32, Andrew P. Boright12, David Tregouet33, 34, Beata Gyorgy33, 34, Janet K. Snell-Bergeon35, David M. Maahs36, Shelley B. Bull37, Angelo J. Canty38, Colin N.A. Palmer39, Lars Stechemesser40, Bernhard Paulweber40, Raimund Weitgasser41, Jelizaveta Sokolovska42, 43, Vita Rovīte44, Valdis Pīrāgs42, 43, Edita Prakapiene45, Lina Radzeviciene46, Rasa Verkauskiene46, Nicolae Mircea Panduru6, 47, Leif C. Groop48, 49, Mark I. McCarthy18, 19, 50, Harvest F. Gu51, 52, Anna M?llsten53, Henrik Falhammar54, 55, Kerstin Brismar54, 55, GENIE Consortium, DCCT/EDIC Research Group, SUMMIT Consortium, Finian Martin9, Peter Rossing21, 56, Tina Costacou32, Gianpaolo Zerbini30, Michel Marre57, 58, 59, Samy Hadjadj60, 61, Amy J. McKnight62, Carol Forsblom5, 6, Gareth McKay62, Catherine Godson9, A. Peter Maxwell62, Matthias Kretzler14, 23, Katalin Susztak13, Helen M. Colhoun16, Andrzej Krolewski15, Andrew D. Paterson12, Per-Henrik Groop5, 6, 7, 63, Stephen S. Rich8, Joel N. Hirschhorn2, 3, Jose C. Florez3, 4, 64, 65AFFILIATIONSFamily Medicine and Public Health, University of California San Diego, La Jolla, CA 92093 USA. Division of Endocrinology/ Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115 USA. Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA 02142 USA. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114 USA. Folkh?lsan Institute of Genetics, Folkh?lsan Research Center, Helsinki, Finland. Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. University of Virginia, 3812B OMS, Charlottesville, VA 22908 USA. Diabetes Complications Research Centre/ Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4 Ireland. University of Utah Division of Nephrology and Hypertension Diabetes and Metabolism Center, University of Utah, Salt Lake City, UT 84132 USA. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4TJ UK. The Hospital for Sick Children, Toronto, ON M5G 0A4 Canada. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA. Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Joslin Diabetes Center, Boston, MA 02115 USA. Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU UK. The Chronic Disease Prevention Unit, National Institute for Health and Welfare, 00271, Helsinki, Finland. Wellcome Trust Centre for Human Genetics, University of Oxford, OX37BN, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, OX37BN, UK. Lund University Diabetes Centre, Malm?, 20502, Sweden. Steno Diabetes Center Copenhagen, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark. Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, 48109 USA. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Cardiometabolic Diseases Research, Boehringer Ingelheim, Ridgefield, CT 06877, USA. Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109 USA. Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85014, USA. University of Wisconsin-Madison, Madison, WI 53726 USA. The George Washington University, Washington, DC 20052 USA. University of Minnesota, Minneapolis, MN 55454 USA. Complications of Diabetes Unit, Diabetes Research Institute (DRI), Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy. University of Washington, Seattle, WA 98195 USA. University of Pittsburgh Public Health, Pittsburgh, PA, 15213, USA. Sorbonne Université, UPMC Univ Paris 06, INSERM UMR_S 1166, Paris, France. ICAN Institute for Cardiometabolism and Nutrition, Paris, France. University of Colorado School of Medicine, Aurora, CO 80045 USA. Department of Pediatrics-Endocrinology, Stanford University, Stanford, California 94305 USA. The Lunenfeld-Tenenbaum Research Institute and University of Toronto, Toronto, ON M5G 0A4 Canada. Dept. of Mathematics & Statistics, McMaster University, Hamilton, Ontario, L8S 4K1 Canada. Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, DD19SY UK. First Department of Medicine, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, Austria. Department of Medicine, Diakonissen-Wehrle Hospital, Salzburg, Austria. University of Latvia, Rai?a 19, Riga, Latvia. Pauls Stradins University Hospital, Pilsonu 13, Riga, Latvia. Latvian Biomedical Research and Study Centre, Rātsupītes 1, Riga, Latvia. Medical Academy, Lithuanian University of Health Sciences, Kaunas, LT 44307 Lithuania. Institute of Endocrinology, Medical Academy, Lithuanian University of Health, Kaunas 44307 Lithuania Sciences. 2nd Clinical Department, Carol Davila University of Medicine and Pharmacy, Bucharest, 020021 Romania. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malm?, 205 02 Sweden. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, C329b, Finland. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX37BN, UK. Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Huddinge, Stockholm 14152 Sweden. School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009 China. Ume? University, Department of Clinical Sciences, Pediatrics, 90187 Ume?, Sweden. Rolf Luft Center for Diabetes Research and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176 Sweden. Department of Endocrinology, Diabetes and Metabolism, Karolinska University Hospital, Stockholm, 17176 Sweden. University of Copenhagen, Copenhagen, Denmark. Assistance Publique – H?pitaux de Paris (AP-HP), Bichat Hospital, DHU FIRE, Department of Diabetology, Endocrinology and Nutrition, Paris, France. Paris Diderot University, Sorbonne Paris Cité, UFR de Médecine, Paris, France; INSERM, UMRS 1138, Cordeliers Research Center, Paris, France. Fondation Ophtalmologique Adolphe de Rothschild, Paris, France. Centre Hospitalier Universitaire de Poitiers, Department of Endocrinology and Diabetology, Poitiers, France; INSERM CIC 1402, Poitiers, France. L’institut du thorax, INSERM, CNRS, CHU Nantes, Nantes, France. Centre for Public Health, Queens University of Belfast, Northern Ireland, BT7 1NN UK. Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia. Diabetes Unit, Massachusetts General Hospital, Boston MA 02114 USA. Department of Medicine, Harvard Medical School, Boston MA 02115* These authors contributed equallyCorresponding author: Jose C. Florez jcflorez@mgh.harvard.eduLead author: Jose C. FlorezSIGNIFICANCE STATEMENT Diabetic kidney disease (DKD) is a devastating microvascular complication of both type 1 and type 2 diabetes. It has been shown to have a heritable component, but prior searches for the genetic determinants of this condition have had limited success. In this study, a new international genomics consortium (the Diabetic Nephropathy Collaborative Research Initiative, funded by the JDRF) has coalesced to assemble nearly 20,000 samples from participants with type 1 diabetes, with and without kidney disease. We report 16 new signals at genome-wide significance and begin to describe the genetic architecture of this globally relevant phenotype. Our top signal centers on a protective missense coding variant at COL4A3, which encodes an integral component of the glomerular basement membrane that when mutated causes Alport syndrome. ABSTRACT Background: Diabetic kidney disease (DKD) is a heritable but poorly understood complication of diabetes. Methods: To identify genetic variants predisposing to DKD, we performed genome-wide association analyses in 19,406 individuals with type 1 diabetes (T1D) using a spectrum of DKD definitions based on albuminuria and renal function. Results: We identified 16 genome-wide significant loci. The variant with the strongest association (rs55703767) is a common missense mutation in the collagen type IV alpha 3 chain (COL4A3) gene, which encodes a major structural component of the glomerular basement membrane (GBM) implicated in heritable nephropathies. The rs55703767 minor allele (Asp326Tyr) is protective against several definitions of DKD, including albuminuria and end-stage renal disease. Three other loci are in or near genes with known or suggestive involvement in DKD (BMP7) or renal biology (COLEC11 and DDR1). Conclusion: The 16 DKD-associated loci provide novel insights into the pathogenesis of DKD, identifying potential biological targets for prevention and treatment.KEYWORDSDiabetic kidney disease, genome-wide association study, type 1 diabetes, genetics, diabetic complications, COL4A3 INTRODUCTIONThe devastating diabetic complication of diabetic kidney disease (DKD) is the major cause of end-stage renal disease (ESRD) worldwidePEVuZE5vdGU+PENpdGUgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+Q2VudGVycyBmb3IgRGlzZWFz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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+Q2VudGVycyBmb3IgRGlzZWFz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ADDIN EN.CITE.DATA 1,2. Current treatment strategies at best slow the progression of DKD, and do not halt or reverse the disease. Although improved glycemic control influences the rate of diabetic complications, a large portion of the variation in DKD susceptibility remains unexplained: one third of people with type 1 diabetes (T1D) develop DKD despite adequate glycemic control, while others maintain normal renal function despite long-term severe chronic hyperglycemia ADDIN EN.CITE <EndNote><Cite><Author>Krolewski</Author><Year>1996</Year><RecNum>16</RecNum><DisplayText><style face="superscript">3</style></DisplayText><record><rec-number>16</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1336686827">16</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Krolewski, M.</author><author>Eggers, P.W.</author><author>Warram, J.H.</author></authors></contributors><titles><title>Magnitude of end-stage renal disease in IDDM: a 35 year follow-up study</title><secondary-title>Kidney Int</secondary-title></titles><periodical><full-title>Kidney Int</full-title></periodical><pages>2041-2046</pages><volume>50</volume><number>6</number><dates><year>1996</year></dates><urls></urls></record></Cite></EndNote>3. Though DKD demonstrates both familial clusteringPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXJqdXRzYWxvPC9BdXRob3I+PFllYXI+MjAwNDwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXJqdXRzYWxvPC9BdXRob3I+PFllYXI+MjAwNDwvWWVh
cj48UmVjTnVtPjQ8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0
Ij40LTY8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40PC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0id2FwdjBhOXRxYXJwd3plNXow
dDU5ZjVoejB0cncyNXpmcDJhIiB0aW1lc3RhbXA9IjE1NDI2NzYwOTIiPjQ8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkhhcmp1dHNhbG8sIFYuPC9hdXRob3I+PGF1dGhv
cj5LYXRvaCwgUy48L2F1dGhvcj48YXV0aG9yPlNhcnRpLCBDLjwvYXV0aG9yPjxhdXRob3I+VGFq
aW1hLCBOLjwvYXV0aG9yPjxhdXRob3I+VHVvbWlsZWh0bywgSi48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5OYXRpb25hbCBQdWJsaWMgSGVhbHRoIEluc3Rp
dHV0ZSwgTWFubmVyaGVpbWludGllIDE2NiwgRklOLTAwMzAwIEhlbHNpbmtpLCBGaW5sYW5kLiB2
YWxtYS5oYXJqdXRzYWxvQGt0bC5maTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlBvcHVs
YXRpb24tYmFzZWQgYXNzZXNzbWVudCBvZiBmYW1pbGlhbCBjbHVzdGVyaW5nIG9mIGRpYWJldGlj
IG5lcGhyb3BhdGh5IGluIHR5cGUgMSBkaWFiZXRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5E
aWFiZXRlczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkRpYWJldGVzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjQ0OS01NDwvcGFnZXM+
PHZvbHVtZT41Mzwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxlZGl0aW9uPjIwMDQvMDgvMjg8
L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+
QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFBy
ZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5Db2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29y
ZD5EaWFiZXRlcyBNZWxsaXR1cywgVHlwZSAxLyplcGlkZW1pb2xvZ3kvKmdlbmV0aWNzPC9rZXl3
b3JkPjxrZXl3b3JkPkRpYWJldGljIE5lcGhyb3BhdGhpZXMvKmVwaWRlbWlvbG9neS8qZ2VuZXRp
Y3M8L2tleXdvcmQ+PGtleXdvcmQ+RmFtaWx5IEhlYWx0aDwva2V5d29yZD48a2V5d29yZD5GZW1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+RmlubGFuZC9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdv
cmQ+R2VuZXRpYyBQcmVkaXNwb3NpdGlvbiB0byBEaXNlYXNlL2VwaWRlbWlvbG9neTwva2V5d29y
ZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5jaWRlbmNlPC9rZXl3b3JkPjxr
ZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+
PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5SZWdpc3RyaWVzPC9rZXl3b3JkPjxrZXl3
b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95
ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+
MDAxMi0xNzk3IChQcmludCkmI3hEOzAwMTItMTc5NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv
bi1udW0+MTUzMzE1NTg8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0
dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE1MzMxNTU4PC91cmw+PC9yZWxhdGVk
LXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlF1aW5uPC9BdXRob3I+
PFllYXI+MTk5NjwvWWVhcj48UmVjTnVtPjIwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4y
MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9ImR6cjVzdnIy
a3d0MmQ1ZXo5ZXB4OXB4NnhzNTA1OXY5enhhdiIgdGltZXN0YW1wPSIxMzM2Njg2ODg1Ij4yMDwv
a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y
ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UXVpbm4sIE0uPC9hdXRob3I+
PGF1dGhvcj5BbmdlbGljbywgTS4gQy48L2F1dGhvcj48YXV0aG9yPldhcnJhbSwgSi4gSC48L2F1
dGhvcj48YXV0aG9yPktyb2xld3NraSwgQS4gUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz5TZWN0aW9uIG9uIEVwaWRlbWlvbG9neSBhbmQgR2VuZXRpY3Ms
IEpvc2xpbiBEaWFiZXRlcyBDZW50ZXIsIEJvc3RvbiwgTUEgMDIyMTUsIFVTQS48L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5GYW1pbGlhbCBmYWN0b3JzIGRldGVybWluZSB0aGUgZGV2ZWxv
cG1lbnQgb2YgZGlhYmV0aWMgbmVwaHJvcGF0aHkgaW4gcGF0aWVudHMgd2l0aCBJRERNPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPkRpYWJldG9sb2dpYTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz
PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkRpYWJldG9sb2dpYTwvZnVsbC10aXRsZT48YWJici0x
PkRpYWJldG9sb2dpYTwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+OTQwLTU8L3BhZ2VzPjx2
b2x1bWU+Mzk8L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1
bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWxidW1pbnVyaWEvZXBpZGVtaW9sb2d5LypnZW5ldGljczwv
a2V5d29yZD48a2V5d29yZD5Db2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Db21wYXJh
dGl2ZSBTdHVkeTwva2V5d29yZD48a2V5d29yZD5EaWFiZXRlcyBNZWxsaXR1cywgSW5zdWxpbi1E
ZXBlbmRlbnQvKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RGlhYmV0aWMgTmVwaHJv
cGF0aGllcy9lcGlkZW1pb2xvZ3kvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwv
a2V5d29yZD48a2V5d29yZD5IdW1hbjwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdv
cmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD4qTnVjbGVhciBGYW1pbHk8L2tleXdv
cmQ+PGtleXdvcmQ+UGF0aWVudCBTZWxlY3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0
b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlN1cHBvcnQsIFUuUy4gR292JmFwb3M7dCwgUC5ILlMuPC9r
ZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48
eWVhcj4xOTk2PC95ZWFyPjwvZGF0ZXM+PGFjY2Vzc2lvbi1udW0+ODg1ODIxNjwvYWNjZXNzaW9u
LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L2h0YmluLXBvc3QvRW50cmV6L3F1ZXJ5P2RiPW0mYW1wO2Zvcm09NiZhbXA7ZG9wdD1yJmFtcDt1
aWQ9ODg1ODIxNjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENp
dGU+PEF1dGhvcj5TZWFxdWlzdDwvQXV0aG9yPjxZZWFyPjE5ODk8L1llYXI+PFJlY051bT4xODwv
UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48
a2V5IGFwcD0iRU4iIGRiLWlkPSJkenI1c3ZyMmt3dDJkNWV6OWVweDlweDZ4czUwNTl2OXp4YXYi
IHRpbWVzdGFtcD0iMTMzNjY4Njg2OCI+MTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUg
bmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9y
cz48YXV0aG9yPlNlYXF1aXN0LCBFUjwvYXV0aG9yPjxhdXRob3I+R29ldHosIEZDPC9hdXRob3I+
PGF1dGhvcj5SaWNoLCBTPC9hdXRob3I+PGF1dGhvcj5CYXJib3NhLCBKPC9hdXRob3I+PC9hdXRo
b3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkZhbWlsaWFsIGNsdXN0ZXJpbmcgb2Yg
ZGlhYmV0aWMga2lkbmV5IGRpc2Vhc2UuIEV2aWRlbmNlIGZvciBnZW5ldGljIHN1c2NlcHRpYmls
aXR5IHRvIGRpYWJldGljIG5lcGhyb3BhdGh5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk4gRW5n
bCBKIE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+TiBFbmdsIEogTWVkPC9hbHQtdGl0
bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TiBFbmdsIEogTWVkPC9mdWxsLXRp
dGxlPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TiBFbmdsIEogTWVk
PC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjExNjEtMTE2NTwvcGFnZXM+PHZv
bHVtZT4zMjA8L3ZvbHVtZT48bnVtYmVyPjE4PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjE5ODk8L3ll
YXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXkgNCwgMTk4OTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz
Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vY29udGVudC5uZWptLm9yZy9jZ2kvY29u
dGVudC9hYnN0cmFjdC8zMjAvMTgvMTE2MTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3Jl
Y29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA 4-6 and single nucleotide polymorphism (SNP) heritabilityPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kaG9sbTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kaG9sbTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+
PFJlY051bT40NTc8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0
Ij43PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDU3PC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iZHpyNXN2cjJrd3QyZDVlejll
cHg5cHg2eHM1MDU5djl6eGF2IiB0aW1lc3RhbXA9IjE1MDc4NjAwODIiPjQ1Nzwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2FuZGhvbG0sIE4uPC9hdXRob3I+PGF1dGhv
cj5WYW4gWnV5ZGFtLCBOLjwvYXV0aG9yPjxhdXRob3I+QWhscXZpc3QsIEUuPC9hdXRob3I+PGF1
dGhvcj5KdWxpdXNkb3R0aXIsIFQuPC9hdXRob3I+PGF1dGhvcj5EZXNobXVraCwgSC4gQS48L2F1
dGhvcj48YXV0aG9yPlJheW5lciwgTi4gVy48L2F1dGhvcj48YXV0aG9yPkRpIENhbWlsbG8sIEIu
PC9hdXRob3I+PGF1dGhvcj5Gb3JzYmxvbSwgQy48L2F1dGhvcj48YXV0aG9yPkZhZGlzdGEsIEou
PC9hdXRob3I+PGF1dGhvcj5aaWVtZWssIEQuPC9hdXRob3I+PGF1dGhvcj5TYWxlbSwgUi4gTS48
L2F1dGhvcj48YXV0aG9yPkhpcmFraSwgTC4gVC48L2F1dGhvcj48YXV0aG9yPlBlenpvbGVzaSwg
TS48L2F1dGhvcj48YXV0aG9yPlRyZWdvdWV0LCBELjwvYXV0aG9yPjxhdXRob3I+RGFobHN0cm9t
LCBFLjwvYXV0aG9yPjxhdXRob3I+VmFsbywgRS48L2F1dGhvcj48YXV0aG9yPk9za29sa292LCBO
LjwvYXV0aG9yPjxhdXRob3I+TGFkZW52YWxsLCBDLjwvYXV0aG9yPjxhdXRob3I+TWFyY292ZWNj
aGlvLCBNLiBMLjwvYXV0aG9yPjxhdXRob3I+Q29vcGVyLCBKLjwvYXV0aG9yPjxhdXRob3I+U2Ft
Ym8sIEYuPC9hdXRob3I+PGF1dGhvcj5NYWxvdmluaSwgQS48L2F1dGhvcj48YXV0aG9yPk1hbmZy
aW5pLCBNLjwvYXV0aG9yPjxhdXRob3I+TWNLbmlnaHQsIEEuIEouPC9hdXRob3I+PGF1dGhvcj5M
YWplciwgTS48L2F1dGhvcj48YXV0aG9yPkhhcmp1dHNhbG8sIFYuPC9hdXRob3I+PGF1dGhvcj5H
b3JkaW4sIEQuPC9hdXRob3I+PGF1dGhvcj5QYXJra29uZW4sIE0uPC9hdXRob3I+PGF1dGhvcj5G
aW5uRGlhbmUgU3R1ZHkgR3JvdXAsIEphYWtrbyBUdW9taWxlaHRvPC9hdXRob3I+PGF1dGhvcj5M
eXNzZW5rbywgVi48L2F1dGhvcj48YXV0aG9yPk1jS2VpZ3VlLCBQLiBNLjwvYXV0aG9yPjxhdXRo
b3I+UmljaCwgUy4gUy48L2F1dGhvcj48YXV0aG9yPkJyb3NuYW4sIE0uIEouPC9hdXRob3I+PGF1
dGhvcj5GYXVtYW4sIEUuPC9hdXRob3I+PGF1dGhvcj5CZWxsYXp6aSwgUi48L2F1dGhvcj48YXV0
aG9yPlJvc3NpbmcsIFAuPC9hdXRob3I+PGF1dGhvcj5IYWRqYWRqLCBTLjwvYXV0aG9yPjxhdXRo
b3I+S3JvbGV3c2tpLCBBLjwvYXV0aG9yPjxhdXRob3I+UGF0ZXJzb24sIEEuIEQuPC9hdXRob3I+
PGF1dGhvcj5EY2N0L0VkaWMgU3R1ZHkgR3JvdXAsIEpvc2UgQy4gRmxvcmV6PC9hdXRob3I+PGF1
dGhvcj5IaXJzY2hob3JuLCBKLiBOLjwvYXV0aG9yPjxhdXRob3I+TWF4d2VsbCwgQS4gUC48L2F1
dGhvcj48YXV0aG9yPkdlbmllIENvbnNvcnRpdW0sIERhdmlkIER1bmdlcjwvYXV0aG9yPjxhdXRo
b3I+Q29iZWxsaSwgQy48L2F1dGhvcj48YXV0aG9yPkNvbGhvdW4sIEguIE0uPC9hdXRob3I+PGF1
dGhvcj5Hcm9vcCwgTC48L2F1dGhvcj48YXV0aG9yPk1jQ2FydGh5LCBNLiBJLjwvYXV0aG9yPjxh
dXRob3I+R3Jvb3AsIFAuIEguPC9hdXRob3I+PGF1dGhvcj5TdW1taXQgQ29uc29ydGl1bTwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZvbGtoYWxzYW4gSW5z
dGl0dXRlIG9mIEdlbmV0aWNzLCBGb2xraGFsc2FuIFJlc2VhcmNoIENlbnRlciwgSGVsc2lua2ks
IEZpbmxhbmQuJiN4RDtBYmRvbWluYWwgQ2VudGVyLCBOZXBocm9sb2d5LCBVbml2ZXJzaXR5IG9m
IEhlbHNpbmtpIGFuZCBIZWxzaW5raSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBIZWxzaW5raSwgRmlu
bGFuZC4mI3hEO1Jlc2VhcmNoIFByb2dyYW1zIFVuaXQsIERpYWJldGVzIGFuZCBPYmVzaXR5LCBV
bml2ZXJzaXR5IG9mIEhlbHNpbmtpLCBIZWxzaW5raSwgRmlubGFuZC4mI3hEO1dlbGxjb21lIFRy
dXN0IENlbnRyZSBmb3IgSHVtYW4gR2VuZXRpY3MsIGFuZC4mI3hEO094Zm9yZCBDZW50cmUgZm9y
IERpYWJldGVzLCBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtLCBVbml2ZXJzaXR5IG9mIE94
Zm9yZCwgT3hmb3JkLCBVbml0ZWQgS2luZ2RvbS4mI3hEO01lZGljYWwgUmVzZWFyY2ggSW5zdGl0
dXRlLCBhbmQuJiN4RDtEZXBhcnRtZW50IG9mIENsaW5pY2FsIFNjaWVuY2VzLCBEaWFiZXRlcyBh
bmQgRW5kb2NyaW5vbG9neSwgU2thbmUgVW5pdmVyc2l0eSBIb3NwaXRhbCwgTHVuZCBVbml2ZXJz
aXR5LCBNYWxtbywgU3dlZGVuLiYjeEQ7RGl2aXNpb24gb2YgUG9wdWxhdGlvbiBIZWFsdGggU2Np
ZW5jZXMsIFVuaXZlcnNpdHkgb2YgRHVuZGVlLCBEdW5kZWUsIFVuaXRlZCBLaW5nZG9tLiYjeEQ7
SHVtYW4gR2VuZXRpY3MsIFdlbGxjb21lIFRydXN0IFNhbmdlciBJbnN0aXR1dGUsIEhpbnh0b24s
IFVuaXRlZCBLaW5nZG9tLiYjeEQ7RGVwYXJ0bWVudCBvZiBJbmZvcm1hdGlvbiBFbmdpbmVlcmlu
ZywgVW5pdmVyc2l0eSBvZiBQYWRvdmEsIFBhZG92YSwgSXRhbHkuJiN4RDtDb21wdXRhdGlvbmFs
IFNjaWVuY2VzLCBQZml6ZXIgV29ybGR3aWRlIFJlc2VhcmNoIGFuZCBEZXZlbG9wbWVudCwgQmVy
bGluLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudHMgb2YgR2VuZXRpY3MsIGFuZC4mI3hEO1Byb2dy
YW1zIGluIE1ldGFib2xpc20gYW5kIE1lZGljYWwgYW5kIFBvcHVsYXRpb24gR2VuZXRpY3MsIEJy
b2FkIEluc3RpdHV0ZSBvZiB0aGUgTWFzc2FjaHVzZXR0cyBJbnN0aXR1dGUgb2YgVGVjaG5vbG9n
eSBhbmQgSGFydmFyZCBVbml2ZXJzaXR5LCBDYW1icmlkZ2UsIE1hc3NhY2h1c2V0dHMuJiN4RDtE
aXZpc2lvbnMgb2YgRW5kb2NyaW5vbG9neSBhbmQgR2VuZXRpY3MsIEJvc3RvbiBDaGlsZHJlbiZh
cG9zO3MgSG9zcGl0YWwsIEJvc3RvbiwgTWFzc2FjaHVzZXR0cy4mI3hEO0dlbmV0aWNzIGFuZCBH
ZW5vbWUgQmlvbG9neSBQcm9ncmFtLCBIb3NwaXRhbCBmb3IgU2ljayBDaGlsZHJlbiwgVG9yb250
bywgT250YXJpbywgQ2FuYWRhLiYjeEQ7U2VjdGlvbiBvbiBHZW5ldGljcyBhbmQgRXBpZGVtaW9s
b2d5LCBKb3NsaW4gRGlhYmV0ZXMgQ2VudGVyLCBCb3N0b24sIE1hc3NhY2h1c2V0dHMuJiN4RDtT
b3Jib25uZSBVbml2ZXJzaXRpZXMsIFBpZXJyZSBldCBNYXJpZSBDdXJpZSBVbml2ZXJzaXR5IChV
UE1DKSBhbmQgTmF0aW9uYWwgSW5zdGl0dXRlIGZvciBIZWFsdGggYW5kIE1lZGljYWwgUmVzZWFy
Y2gsIE1peGVkIFJlc2VhcmNoIFVuaXQgaW4gSGVhbHRoIChVTVJfUykgMTE2NiwgUGFyaXMsIEZy
YW5jZS4mI3hEO0luc3RpdHV0ZSBmb3IgQ2FyZGlvbWV0YWJvbGlzbSBhbmQgTnV0cml0aW9uLCBH
ZW5vbWljcyBhbmQgcGF0aG9waHlzaW9sb2d5IG9mIENhcmRpb3Zhc2N1bGFyIGRpc2Vhc2VzLCBQ
YXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBQYWVkaWF0cmljcywgSW5zdGl0dXRlIG9m
IE1ldGFib2xpYyBTY2llbmNlLCBhbmQuJiN4RDtEZXBhcnRtZW50IG9mIENoZW1pY2FsIEVuZ2lu
ZWVyaW5nIGFuZCBCaW90ZWNobm9sb2d5LCBVbml2ZXJzaXR5IG9mIENhbWJyaWRnZSwgQ2FtYnJp
ZGdlLCBVbml0ZWQgS2luZ2RvbS4mI3hEO0RlcGFydG1lbnQgb2YgRWxlY3RyaWNhbCwgQ29tcHV0
ZXIgYW5kIEJpb21lZGljYWwgRW5naW5lZXJpbmcsIFVuaXZlcnNpdHkgb2YgUGF2aWEsIFBhdmlh
LCBJdGFseS4mI3hEO0xhYm9yYXRvcnkgb2YgSW5mb3JtYXRpY3MgYW5kIFN5c3RlbXMgRW5naW5l
ZXJpbmcgZm9yIENsaW5pY2FsIFJlc2VhcmNoLCBTY2llbnRpZmljIEluc3RpdHV0ZSBmb3IgUmVz
ZWFyY2gsIEhvc3BpdGFsaXphdGlvbiBhbmQgSGVhbHRoIENhcmUsIElSQ0NTIChJbnN0aXR1dG8g
ZGkgUmljb3Zlcm8gZSBDdXJhIGEgQ2FyYXR0ZXJlIFNjaWVudGlmaWNvKTsgU2FsdmF0b3JlIE1h
dWdlcmkgRm91bmRhdGlvbiwgUGF2aWEsIEl0YWx5LiYjeEQ7TmVwaHJvbG9neSBSZXNlYXJjaCwg
Q2VudHJlIGZvciBQdWJsaWMgSGVhbHRoLCBRdWVlbiZhcG9zO3MgVW5pdmVyc2l0eSBvZiBCZWxm
YXN0LCBCZWxmYXN0LCBVbml0ZWQgS2luZ2RvbS4mI3hEO0RpYWJldGljIENvbXBsaWNhdGlvbnMs
IFN0ZW5vIERpYWJldGVzIENlbnRlciwgR2VudG9mdGUsIERlbm1hcmsuJiN4RDtUaGUgQ2hyb25p
YyBEaXNlYXNlIFByZXZlbnRpb24gVW5pdCwgTmF0aW9uYWwgSW5zdGl0dXRlIGZvciBIZWFsdGgg
YW5kIFdlbGZhcmUsIEhlbHNpbmtpLCBGaW5sYW5kLiYjeEQ7Q2VudHJlIGZvciBQb3B1bGF0aW9u
IEhlYWx0aCBTY2llbmNlcywgVW5pdmVyc2l0eSBvZiBFZGluYnVyZ2gsIEVkaW5idXJnaCwgVW5p
dGVkIEtpbmdkb20uJiN4RDtDZW50ZXIgZm9yIFB1YmxpYyBIZWFsdGggR2Vub21pY3MsIFVuaXZl
cnNpdHkgb2YgVmlyZ2luaWEsIENoYXJsb3R0ZXN2aWxsZSwgVmlyZ2luaWEuJiN4RDtDYXJkaW92
YXNjdWxhciBhbmQgTWV0YWJvbGljIERpc2Vhc2VzIFJlc2VhcmNoIFVuaXQsIGFuZC4mI3hEO0Nv
bXB1dGF0aW9uYWwgU2NpZW5jZXMsIFBmaXplciBXb3JsZHdpZGUgUmVzZWFyY2ggYW5kIERldmVs
b3BtZW50LCBDYW1icmlkZ2UsIE1hc3NhY2h1c2V0dHMuJiN4RDtEZXBhcnRtZW50IG9mIEhlYWx0
aCwgQWFyaHVzIFVuaXZlcnNpdHksIEFhcmh1cywgRGVubWFyay4mI3hEO05vdm8gTm9yZGlzayBG
b3VuZGF0aW9uIENlbnRlciBmb3IgQmFzaWMgTWV0YWJvbGljIFJlc2VhcmNoLCBVbml2ZXJzaXR5
IG9mIENvcGVuaGFnZW4sIENvcGVuaGFnZW4sIERlbm1hcmsuJiN4RDtGdW5jdGlvbmFsIFJlc2Vh
cmNoIFVuaXQgb2YgTWVkaWNpbmUgYW5kIFBoYXJtYWN5LCBVbml2ZXJzaXR5IG9mIFBvaXRpZXJz
LCBQb2l0aWVycywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBFbmRvY3Jpbm9sb2d5LURpYWJl
dG9sb2d5IGFuZCBDZW50ZXIgb2YgQ2xpbmljYWwgSW52ZXN0aWdhdGlvbiwgUG9pdGllcnMgVW5p
dmVyc2l0eSBIb3NwaXRhbCwgUG9pdGllcnMsIEZyYW5jZS4mI3hEO0luc3RpdHV0ZSBOYXRpb25h
bCBwb3VyIGxhIFNhbnRlIGV0IGxhIFJlY2hlcmNoZSBNZWRpY2FsZSwgTmF0aW9uYWwgSW5zdGl0
dXRlIGZvciBIZWFsdGggYW5kIE1lZGljYWwgUmVzZWFyY2gsIENlbnRlciBvZiBDbGluaWNhbCBJ
bnZlc3RpZ2F0aW9uIDE0MDIgYW5kIFVuaXQgMTA4MiwgUG9pdGllcnMsIEZyYW5jZS4mI3hEO1Jl
Z2lvbmFsIE5lcGhyb2xvZ3kgVW5pdCwgQmVsZmFzdCBDaXR5IEhvc3BpdGFsLCBCZWxmYXN0LCBV
bml0ZWQgS2luZ2RvbTsgYW5kLiYjeEQ7T3hmb3JkIE5JSFIgQmlvbWVkaWNhbCBSZXNlYXJjaCBD
ZW50cmUsIE94Zm9yZCBVbml2ZXJzaXR5IEhvc3BpdGFscyBUcnVzdCwgT3hmb3JkLCBVbml0ZWQg
S2luZ2RvbS4mI3hEO0ZvbGtoYWxzYW4gSW5zdGl0dXRlIG9mIEdlbmV0aWNzLCBGb2xraGFsc2Fu
IFJlc2VhcmNoIENlbnRlciwgSGVsc2lua2ksIEZpbmxhbmQ7IHBlci1oZW5yaWsuZ3Jvb3BAaGVs
c2lua2kuZmkuJiN4RDtCYWtlciBJREkgKEludGVybmF0aW9uYWwgRGlhYmV0ZXMgSW5zdGl0dXRl
KSBIZWFydCBhbmQgRGlhYmV0ZXMgSW5zdGl0dXRlLCBNZWxib3VybmUsIFZpY3RvcmlhLCBBdXN0
cmFsaWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIEdlbmV0aWMgTGFuZHNjYXBl
IG9mIFJlbmFsIENvbXBsaWNhdGlvbnMgaW4gVHlwZSAxIERpYWJldGVzPC90aXRsZT48c2Vjb25k
YXJ5LXRpdGxlPkogQW0gU29jIE5lcGhyb2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkpv
dXJuYWwgb2YgdGhlIEFtZXJpY2FuIFNvY2lldHkgb2YgTmVwaHJvbG9neSA6IEpBU048L2FsdC10
aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEFtIFNvYyBOZXBocm9sPC9m
dWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NTU3LTU3NDwvcGFnZXM+PHZvbHVtZT4yODwv
dm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9r
ZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkRpYWJldGVzIE1lbGxpdHVz
LCBUeXBlIDEvKmNvbXBsaWNhdGlvbnMvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkRpYWJl
dGljIE5lcGhyb3BhdGhpZXMvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5
d29yZD48a2V5d29yZD5HZW5vbWUtV2lkZSBBc3NvY2lhdGlvbiBTdHVkeTwva2V5d29yZD48a2V5
d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRk
bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48L2tleXdvcmRz
PjxkYXRlcz48eWVhcj4yMDE3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHVi
LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy0zNDUwIChFbGVjdHJvbmljKSYjeEQ7MTA0Ni02Njcz
IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNzY0Nzg1NDwvYWNjZXNzaW9uLW51bT48
dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l
ZC8yNzY0Nzg1NDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj41MjgwMDIwPC9j
dXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xNjgxL0FTTi4yMDE2MDIwMjMxPC9l
bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA 7, the specific genetic factors influencing DKD risk remain largely unknown. Recent genome-wide association studies (GWAS) have only identified a handful of loci for DKD, albuminuria, or estimated glomerular filtration rate (eGFR) in individuals with diabetesZW5jZXMsIFVuaXZlcnNpdHkgb2YgQ29wZW5oYWdlbiwgQ29wZW5oYWdlbiwgRGVubWFyay4mI3hE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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JeWVuZ2FyPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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==
ADDIN EN.CITE.DATA I3hEO1ZhbmRlcmJpbHQgVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIDQ0OCBFc2tpbmQg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==
ADDIN EN.CITE.DATA ZW5jZXMsIFVuaXZlcnNpdHkgb2YgQ29wZW5oYWdlbiwgQ29wZW5oYWdlbiwgRGVubWFyay4mI3hE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ADDIN EN.CITE.DATA 7-13. Potential reasons for the limited success include small sample sizes, modest genetic effects, and lack of consistency of phenotype definitions and statistical analyses across studies. Through collaboration within the JDRF Diabetes Nephropathy Collaborative Research Initiative (DNCRI), we adopted three approaches to improve our ability to find new genetic risk factors for DKD: 1) assembling a large collection of T1D cohorts with harmonized DKD phenotypes, 2) creating a comprehensive set of detailed DKD definitions, and 3) augmenting genotype data with low frequency and exome array variants. METHODS Cohorts and Phenotype Definitions. The GWAS meta-analysis included up to 19,406 patients with T1D of European origin from 17 cohorts (for study list and details see Table S1). All participants gave informed consent and all studies were approved by ethics committees from participating institutions. We defined a total of 10 different case-control outcomes to cover the different aspects of renal complications, using both albuminuria and eGFR (Figure 1). Five comparisons (“All vs. ctrl”, “Micro”, “DN”, “Macro”, and “ESRD vs. macro”) were based on albuminuria, measured by albumin excretion rate (AER) from overnight or 24-h urine collection, or by albumin creatinine ratio (ACR). Two out of three consecutive collections were required (when available) to classify the renal status of subjects as either normoalbuminuria, microalbuminuria, macroalbuminuria, or ESRD; for detailed thresholds, see Table S9. Controls with normal AER were required to have a minimum diabetes duration of 15 years; subjects with microalbuminuria/macroalbuminuria/ESRD were required to have minimum diabetes duration of 5/10/10 years, respectively, to exclude renal complications of non-diabetic origins. Two comparisons (“ESRD vs. ctrl” and “ESRD vs. non-ESRD”) were based on presence of ESRD as defined by eGFR<15 mL/min or dialysis or renal transplant. Two phenotypes (“CKD” and “CKD extreme”) were defined based on eGFR estimated by the CKD-EPI formula: controls had eGFR ≥60ml/min/1.73m2 for both phenotypes, and ≥15 years of diabetes duration; cases had eGFR <60ml/min/1.73m2 for the “CKD” phenotype, and eGFR <15 ml/min/1.73m2 or dialysis or renal transplant for the “CKD extreme” phenotype, and ≥10 years of diabetes duration. For the “CKD-DN” phenotype that combined both albuminuria and eGFR data, controls were required to have both eGFR ≥60ml/min/1.73m2 and normoalbuminuria; cases had both eGFR <45ml/min/1.73m2 and micro- or macroalbuminuria, or ESRD. GWAS Genotyping, Quality Control and Imputation. All study samples underwent genotyping, quality control (QC) and imputation centrally at the University of Virginia. In brief, samples were genotyped on the HumanCore BeadChip array (Illumina, San Diego, CA, USA), which contains ~250,000 genome-wide tag SNPs and over 200,000 exome-focused variants. All samples were passed through a stringent QC protocol. Following initial genotype calling with Illumina software, all samples were re-called with zCall, a calling algorithm specifically designed for rare SNPs from arrays. Variant orientation and position were aligned to hg19 (Genome Reference Consortium Human Build 37, GRCh37). Variant names were updated using 1000 Genomes as a reference. The data were then filtered for low quality variants (e.g. call rates <95% and excessive deviation from Hardy-Weinberg equilibrium) and samples (e.g. call rates <98%, gender mismatch, extreme heterozygosity). Principal Component Analysis (PCA) was performed separately for each cohort in order to empirically detect and exclude outliers with evidence of non-European ancestry (see supplement for full QC details, and Figure S1 for trait specific Manhattan and QQ plots). Genotypes were expanded to a total of approximately 49 million by imputation, using the minimac imputation toolPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib3dpZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib3dpZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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ADDIN EN.CITE.DATA 14,15 and 1,000 Genomes Project (phase 3v5) as a reference.GWAS Analysis. A genome-wide association analysis was performed for each of the case-control definitions under an additive genetic model, adjusting for age, sex, diabetes duration, study site (where applicable) and principal components. We conducted a second set of analyses adjusting for BMI and HbA1c which we refer to as our fully adjusted covariate model. Allele dosages were used to account for imputation uncertainty. Inverse-variance fixed effects meta-analysis was performed using METAL and the following filters: INFO score >0.3, minor allele count >10 in both cases and controls, and presence of variant in at least two cohorts (Manhattan and QQ plots each trait and covariate model presented in Figure S1). The X chromosome was similarly analyzed for males and females both separately and in a combined analysis, with the exception of using hard call genotypes in place of allele dosages. ADDIN EN.CITE <EndNote><Cite><Author>Li</Author><Year>2005</Year><RecNum>20</RecNum><DisplayText><style face="superscript">16</style></DisplayText><record><rec-number>20</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542677109">20</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Li, J.</author><author>Ji, L.</author></authors></contributors><auth-address>The Ministry of Education (MOE) Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, People's Republic of China.</auth-address><titles><title>Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix</title><secondary-title>Heredity (Edinb)</secondary-title></titles><periodical><full-title>Heredity (Edinb)</full-title></periodical><pages>221-7</pages><volume>95</volume><number>3</number><edition>2005/08/04</edition><keywords><keyword>*Data Interpretation, Statistical</keyword><keyword>*Genetic Predisposition to Disease</keyword><keyword>Genetic Testing/*methods</keyword><keyword>Genetics, Medical/*methods</keyword><keyword>*Models, Genetic</keyword><keyword>*Research Design</keyword></keywords><dates><year>2005</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0018-067X (Print)
0018-067X (Linking)</isbn><accession-num>16077740</accession-num><urls><related-urls><url> We estimated the percentage of variance explained for all genome-wide significant SNPs across all disease definitions using the McKelvey-Zavoina ADDIN EN.CITE <EndNote><Cite><Author>McKelvey</Author><Year>1975</Year><RecNum>515</RecNum><DisplayText><style face="superscript">17</style></DisplayText><record><rec-number>515</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1559260861">515</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McKelvey, Richard D.</author><author>Zavoina, William</author></authors></contributors><titles><title>A statistical model for the analysis of ordinal level dependent variables</title><secondary-title>The Journal of Mathematical Sociology</secondary-title></titles><periodical><full-title>The Journal of Mathematical Sociology</full-title></periodical><pages>103-120</pages><volume>4</volume><number>1</number><dates><year>1975</year><pub-dates><date>1975/01/01</date></pub-dates></dates><publisher>Routledge</publisher><isbn>0022-250X</isbn><urls><related-urls><url> pseudo-R2 statistic predicting continuous latent variables underlying binary outcomes. Glomerular basement membrane measurement in Renin-Angiotensin System Study (RASS). In brief, RASS was a double-blind placebo-controlled randomized trial of enalapril and losartan on renal pathology among 285 normoalbuminuric, normotensive subjects with T1D and normal or increased measured glomerular filtration rate (>90 ml/min/1.73m2).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXVlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXVlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl
Y051bT4xOTwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjE4
PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3YXB2MGE5dHFhcnB3emU1ejB0NTlm
NWh6MHRydzI1emZwMmEiIHRpbWVzdGFtcD0iMTU0MjY3NzA0NCI+MTk8L2tleT48L2ZvcmVpZ24t
a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy
aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hdWVyLCBNLjwvYXV0aG9yPjxhdXRob3I+WmlubWFu
LCBCLjwvYXV0aG9yPjxhdXRob3I+R2FyZGluZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TdWlzc2Es
IFMuPC9hdXRob3I+PGF1dGhvcj5TaW5haWtvLCBBLjwvYXV0aG9yPjxhdXRob3I+U3RyYW5kLCBU
LjwvYXV0aG9yPjxhdXRob3I+RHJ1bW1vbmQsIEsuPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwg
Uy48L2F1dGhvcj48YXV0aG9yPkdvb2R5ZXIsIFAuPC9hdXRob3I+PGF1dGhvcj5HdWJsZXIsIE0u
IEMuPC9hdXRob3I+PGF1dGhvcj5LbGVpbiwgUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIFVuaXZlcnNpdHkg
b2YgTWlubmVzb3RhLCBNaW5uZWFwb2xpcyA1NTQ1NSwgVVNBLiBtYXVlcjAwMkB1bW4uZWR1PC9h
dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVuYWwgYW5kIHJldGluYWwgZWZmZWN0cyBvZiBl
bmFsYXByaWwgYW5kIGxvc2FydGFuIGluIHR5cGUgMSBkaWFiZXRlczwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh
bD48ZnVsbC10aXRsZT5OIEVuZ2wgSiBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBN
ZWQ8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjQwLTUxPC9wYWdlcz48dm9sdW1lPjM2MTwv
dm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMDkvMDcvMDM8L2VkaXRpb24+PGtl
eXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFsYnVtaW51cmlhPC9rZXl3
b3JkPjxrZXl3b3JkPkFuZ2lvdGVuc2luIElJIFR5cGUgMSBSZWNlcHRvciBCbG9ja2Vycy9hZHZl
cnNlIGVmZmVjdHMvKnBoYXJtYWNvbG9neS90aGVyYXBldXRpYzwva2V5d29yZD48a2V5d29yZD51
c2U8L2tleXdvcmQ+PGtleXdvcmQ+QW5naW90ZW5zaW4tQ29udmVydGluZyBFbnp5bWUgSW5oaWJp
dG9ycy9hZHZlcnNlPC9rZXl3b3JkPjxrZXl3b3JkPmVmZmVjdHMvKnBoYXJtYWNvbG9neS90aGVy
YXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+RGlhYmV0ZXMgTWVsbGl0dXMsIFR5cGUgMS8q
ZHJ1ZyB0aGVyYXB5L3BhdGhvbG9neS9waHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+
RGlhYmV0aWMgTmVwaHJvcGF0aGllcy9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+
PGtleXdvcmQ+RGlhYmV0aWMgUmV0aW5vcGF0aHkvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9r
ZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgUHJvZ3Jlc3Npb248L2tleXdvcmQ+PGtleXdvcmQ+RG91
YmxlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5d29yZD5FbmFsYXByaWwvYWR2ZXJzZSBlZmZl
Y3RzLypwaGFybWFjb2xvZ3kvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5H
bG9tZXJ1bGFyIEZpbHRyYXRpb24gUmF0ZS9kcnVnIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+
SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkthcGxhbi1NZWllciBFc3RpbWF0ZTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgR2xvbWVydWx1cy8qZHJ1ZyBlZmZlY3RzL3BhdGhvbG9neTwva2V5d29y
ZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+TG9zYXJ0YW4vYWR2
ZXJzZSBlZmZlY3RzLypwaGFybWFjb2xvZ3kvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3
b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWVzYW5naWFsIENlbGxzL2RydWcgZWZmZWN0cy9w
YXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmVuaW4tQW5naW90ZW5zaW4gU3lzdGVtLypkcnVn
IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0aW5hLypkcnVnIGVmZmVjdHMvcGF0aG9sb2d5
PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRlcz48
ZGF0ZT5KdWwgMjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtNDQwNiAoRWxl
Y3Ryb25pYykmI3hEOzAwMjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk1
NzEyODI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3
Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE5NTcxMjgyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91
cmxzPjxjdXN0b20yPlBNQzI5NzgwMzA8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjEwLjEwNTYvTkVKTW9hMDgwODQwMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+
PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA 18 Participants were followed for 5 years with percutaneous kidney biopsy completed prior to randomization and at 5 years. Structural parameters measured by electron microscopy on biopsy included GBM width, measured by the electron microscopic orthogonal intercept methodPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXVlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl
Y051bT4xOTwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjE4
PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTk8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3YXB2MGE5dHFhcnB3emU1ejB0NTlm
NWh6MHRydzI1emZwMmEiIHRpbWVzdGFtcD0iMTU0MjY3NzA0NCI+MTk8L2tleT48L2ZvcmVpZ24t
a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy
aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hdWVyLCBNLjwvYXV0aG9yPjxhdXRob3I+WmlubWFu
LCBCLjwvYXV0aG9yPjxhdXRob3I+R2FyZGluZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TdWlzc2Es
IFMuPC9hdXRob3I+PGF1dGhvcj5TaW5haWtvLCBBLjwvYXV0aG9yPjxhdXRob3I+U3RyYW5kLCBU
LjwvYXV0aG9yPjxhdXRob3I+RHJ1bW1vbmQsIEsuPC9hdXRob3I+PGF1dGhvcj5Eb25uZWxseSwg
Uy48L2F1dGhvcj48YXV0aG9yPkdvb2R5ZXIsIFAuPC9hdXRob3I+PGF1dGhvcj5HdWJsZXIsIE0u
IEMuPC9hdXRob3I+PGF1dGhvcj5LbGVpbiwgUi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIFVuaXZlcnNpdHkg
b2YgTWlubmVzb3RhLCBNaW5uZWFwb2xpcyA1NTQ1NSwgVVNBLiBtYXVlcjAwMkB1bW4uZWR1PC9h
dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmVuYWwgYW5kIHJldGluYWwgZWZmZWN0cyBvZiBl
bmFsYXByaWwgYW5kIGxvc2FydGFuIGluIHR5cGUgMSBkaWFiZXRlczwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh
bD48ZnVsbC10aXRsZT5OIEVuZ2wgSiBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5OIEVuZ2wgSiBN
ZWQ8L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjQwLTUxPC9wYWdlcz48dm9sdW1lPjM2MTwv
dm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMDkvMDcvMDM8L2VkaXRpb24+PGtl
eXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFsYnVtaW51cmlhPC9rZXl3
b3JkPjxrZXl3b3JkPkFuZ2lvdGVuc2luIElJIFR5cGUgMSBSZWNlcHRvciBCbG9ja2Vycy9hZHZl
cnNlIGVmZmVjdHMvKnBoYXJtYWNvbG9neS90aGVyYXBldXRpYzwva2V5d29yZD48a2V5d29yZD51
c2U8L2tleXdvcmQ+PGtleXdvcmQ+QW5naW90ZW5zaW4tQ29udmVydGluZyBFbnp5bWUgSW5oaWJp
dG9ycy9hZHZlcnNlPC9rZXl3b3JkPjxrZXl3b3JkPmVmZmVjdHMvKnBoYXJtYWNvbG9neS90aGVy
YXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+RGlhYmV0ZXMgTWVsbGl0dXMsIFR5cGUgMS8q
ZHJ1ZyB0aGVyYXB5L3BhdGhvbG9neS9waHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+
RGlhYmV0aWMgTmVwaHJvcGF0aGllcy9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+
PGtleXdvcmQ+RGlhYmV0aWMgUmV0aW5vcGF0aHkvcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9r
ZXl3b3JkPjxrZXl3b3JkPkRpc2Vhc2UgUHJvZ3Jlc3Npb248L2tleXdvcmQ+PGtleXdvcmQ+RG91
YmxlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5d29yZD5FbmFsYXByaWwvYWR2ZXJzZSBlZmZl
Y3RzLypwaGFybWFjb2xvZ3kvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5H
bG9tZXJ1bGFyIEZpbHRyYXRpb24gUmF0ZS9kcnVnIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+
SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkthcGxhbi1NZWllciBFc3RpbWF0ZTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgR2xvbWVydWx1cy8qZHJ1ZyBlZmZlY3RzL3BhdGhvbG9neTwva2V5d29y
ZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+TG9zYXJ0YW4vYWR2
ZXJzZSBlZmZlY3RzLypwaGFybWFjb2xvZ3kvdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3
b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWVzYW5naWFsIENlbGxzL2RydWcgZWZmZWN0cy9w
YXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UmVuaW4tQW5naW90ZW5zaW4gU3lzdGVtLypkcnVn
IGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+UmV0aW5hLypkcnVnIGVmZmVjdHMvcGF0aG9sb2d5
PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRlcz48
ZGF0ZT5KdWwgMjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtNDQwNiAoRWxl
Y3Ryb25pYykmI3hEOzAwMjgtNDc5MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTk1
NzEyODI8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3
Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE5NTcxMjgyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91
cmxzPjxjdXN0b20yPlBNQzI5NzgwMzA8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjEwLjEwNTYvTkVKTW9hMDgwODQwMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+
PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXVlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE.DATA 18. All RASS participants contributed DNA for genotyping. In silico replication in SUMMIT consortium. The SUMMIT consortium included up to 5,193 European Ancestry subjects with type 2 diabetes (T2D), with and without kidney disease. In silico replication was performed on previously published GWAS on DKD with harmonized trait definitions for seven of our primary T1D analyses: “DN”, “Micro”, “Macro”, “ESRD”, “ESRD vs. non-ESRD”, “CKD”, and “CKD-DN” under an additive model, adjusting for age, gender and duration of diabetes.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gWnV5ZGFtPC9BdXRob3I+PFllYXI+MjAxODwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gWnV5ZGFtPC9BdXRob3I+PFllYXI+MjAxODwvWWVh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ADDIN EN.CITE.DATA 13RNAseq and microarray profiling of human kidney samples from the Pima cohort. Kidney biopsy samples from the Pima Indian cohort were manually micro-dissected into 119 glomerular and 100 tubule-interstitial tissues to generate gene expression profiles ADDIN EN.CITE <EndNote><Cite><Author>Cohen</Author><Year>2002</Year><RecNum>38</RecNum><DisplayText><style face="superscript">19</style></DisplayText><record><rec-number>38</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542679994">38</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cohen, C. D.</author><author>Frach, K.</author><author>Schlondorff, D.</author><author>Kretzler, M.</author></authors></contributors><auth-address>Medizinische Poliklinik, Ludwig-Maximilians-University of Munich, Munich, Germany.</auth-address><titles><title>Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application</title><secondary-title>Kidney Int</secondary-title></titles><periodical><full-title>Kidney Int</full-title></periodical><pages>133-40</pages><volume>61</volume><number>1</number><edition>2002/01/12</edition><keywords><keyword>Biopsy/*methods</keyword><keyword>DNA, Complementary</keyword><keyword>Diagnostic Techniques, Urological</keyword><keyword>Dissection/methods</keyword><keyword>Gene Expression</keyword><keyword>Humans</keyword><keyword>Kidney/*pathology</keyword><keyword>Kidney Diseases/*pathology</keyword><keyword>RNA, Messenger/analysis/isolation & purification</keyword><keyword>Reproducibility of Results</keyword><keyword>*Reverse Transcriptase Polymerase Chain Reaction/standards</keyword><keyword>Tissue Preservation</keyword></keywords><dates><year>2002</year><pub-dates><date>Jan</date></pub-dates></dates><isbn>0085-2538 (Print)
0085-2538 (Linking)</isbn><accession-num>11786093</accession-num><urls><related-urls><url>. Expression profiling in the Pima Indian cohort kidney biopsies was carried out using Affymetrix GeneChip Human Genome U133 Array and U133Plus2 Array, as reported previously, and Affymetrix Human Gene ST Genechip 2.1PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJ0aGllcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJ0aGllcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN EN.CITE.DATA 20,21, and on RNA-seq (Illumina). The libraries were prepared using the ClonTech SMARTSeq v4 Ultra Low Input polyA selection kit. Samples were sequenced on a HiSeq 4000, single end, 75bp. Mapping to human reference genome GRCh38.7 was performed with STAR 2.5.2b (). For annotation and quantification of mapping results we used cufflinks, cuffquant and cuffnorm in version 2.2.1 (). After mapping and quantification, PCA and Hierarchical Clustering was used to identify outliers and reiterated until no more outliers could be identified.RNA-sequencing and cis-eQTL analysis in human kidney samples from University of Pennsylvania cohort. Human kidney samples were obtained from surgical nephrectomies for a total of 455 subjects with pathological data and were manually microdissected under a microscope in RNAlater for glomerular and tubular compartments (433 tubule and 335 glomerulus samples). The local renal pathologist performed an unbiased review of the tissue section by scoring multiple parameters, and RNA were prepared using RNAeasy mini columns (Qiagen, Valencia, CA) according to manufacturer's instructions. Whole kidneyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051
bT40MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjIyPC9z
dHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NDE8L3JlYy1udW1iZXI+PGZv
cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3YXB2MGE5dHFhcnB3emU1ejB0NTlmNWh6
MHRydzI1emZwMmEiIHRpbWVzdGFtcD0iMTU0MjY4MDQzMiI+NDE8L2tleT48L2ZvcmVpZ24ta2V5
cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1
dG9ycz48YXV0aG9ycz48YXV0aG9yPktvLCBZLiBBLjwvYXV0aG9yPjxhdXRob3I+WWksIEguPC9h
dXRob3I+PGF1dGhvcj5RaXUsIEMuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywgUy48L2F1dGhvcj48
YXV0aG9yPlBhcmssIEouPC9hdXRob3I+PGF1dGhvcj5MZWRvLCBOLjwvYXV0aG9yPjxhdXRob3I+
S290dGdlbiwgQS48L2F1dGhvcj48YXV0aG9yPkxpLCBILjwvYXV0aG9yPjxhdXRob3I+UmFkZXIs
IEQuIEouPC9hdXRob3I+PGF1dGhvcj5QYWNrLCBNLiBBLjwvYXV0aG9yPjxhdXRob3I+QnJvd24s
IEMuIEQuPC9hdXRob3I+PGF1dGhvcj5TdXN6dGFrLCBLLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv
bnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlJlbmFsLUVsZWN0cm9seXRlIGFuZCBIeXBlcnRlbnNp
b24gRGl2aXNpb24sIERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFBlcmVsbWFuIFNjaG9vbCBvZiBN
ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxhZGVscGhpYSwgUEEgMTkx
MDQsIFVTQS4mI3hEO0luc3RpdHV0ZSBvZiBHZW5ldGljIEVwaWRlbWlvbG9neSwgTWVkaWNhbCBD
ZW50ZXIsIFVuaXZlcnNpdHkgb2YgRnJlaWJ1cmcsIEZhY3VsdHkgb2YgTWVkaWNpbmUsIFVuaXZl
cnNpdHkgb2YgRnJlaWJ1cmcsIEZyZWlidXJnIDc5MTA2LCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVu
dCBvZiBCaW9zdGF0aXN0aWNzIGFuZCBFcGlkZW1pb2xvZ3ksIFBlcmVsbWFuIFNjaG9vbCBvZiBN
ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxhZGVscGhpYSwgUEEgMTkx
MDQsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgR2VuZXRpY3MsIFBlcmVsbWFuIFNjaG9vbCBvZiBN
ZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxhZGVscGhpYSwgUEEgMTkx
MDQsIFVTQS4mI3hEO0RpdmlzaW9uIG9mIEdhc3Ryb2VudGVyb2xvZ3ksIERlcGFydG1lbnQgb2Yg
TWVkaWNpbmUsIFBlcmVsbWFuIFNjaG9vbCBvZiBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5u
c3lsdmFuaWEsIFBoaWxhZGVscGhpYSwgUEEgMTkxMDQsIFVTQS4mI3hEO1JlbmFsLUVsZWN0cm9s
eXRlIGFuZCBIeXBlcnRlbnNpb24gRGl2aXNpb24sIERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFBl
cmVsbWFuIFNjaG9vbCBvZiBNZWRpY2luZSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBo
aWxhZGVscGhpYSwgUEEgMTkxMDQsIFVTQTsgRGVwYXJ0bWVudCBvZiBHZW5ldGljcywgUGVyZWxt
YW4gU2Nob29sIG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFBlbm5zeWx2YW5pYSwgUGhpbGFk
ZWxwaGlhLCBQQSAxOTEwNCwgVVNBLiBFbGVjdHJvbmljIGFkZHJlc3M6IGtzdXN6dGFrQG1haWwu
bWVkLnVwZW5uLmVkdS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5ldGljLVZhcmlh
dGlvbi1Ecml2ZW4gR2VuZS1FeHByZXNzaW9uIENoYW5nZXMgSGlnaGxpZ2h0IEdlbmVzIHdpdGgg
SW1wb3J0YW50IEZ1bmN0aW9ucyBmb3IgS2lkbmV5IERpc2Vhc2U8L3RpdGxlPjxzZWNvbmRhcnkt
dGl0bGU+QW0gSiBIdW0gR2VuZXQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh
bD48ZnVsbC10aXRsZT5BbSBKIEh1bSBHZW5ldDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBh
Z2VzPjk0MC05NTM8L3BhZ2VzPjx2b2x1bWU+MTAwPC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+
PGVkaXRpb24+MjAxNy8wNi8wMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5pbWFsczwv
a2V5d29yZD48a2V5d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPipHZW5lIEV4
cHJlc3Npb24gUmVndWxhdGlvbjwva2V5d29yZD48a2V5d29yZD5HZW5lIEtub2NrZG93biBUZWNo
bmlxdWVzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmUgUmVndWxhdG9yeSBOZXR3b3Jrczwva2V5d29y
ZD48a2V5d29yZD4qR2VuZXRpYyBWYXJpYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+R2Vub21lLVdp
ZGUgQXNzb2NpYXRpb24gU3R1ZHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr
ZXl3b3JkPktpZG5leS9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5LaWRu
ZXkgRGlzZWFzZXMvKmdlbmV0aWNzL3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5MaW5rYWdl
IERpc2VxdWlsaWJyaXVtL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltb3JwaGlzbSwg
U2luZ2xlIE51Y2xlb3RpZGUvZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbnRpdGF0aXZl
IFRyYWl0IExvY2kvZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbnRpdGF0aXZlIFRyYWl0
LCBIZXJpdGFibGU8L2tleXdvcmQ+PGtleXdvcmQ+UmVwcm9kdWNpYmlsaXR5IG9mIFJlc3VsdHM8
L2tleXdvcmQ+PGtleXdvcmQ+WmVicmFmaXNoL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPmJl
dGEtTWFubm9zaWRhc2UvZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+Q2tkPC9rZXl3b3JkPjxr
ZXl3b3JkPkd3YXM8L2tleXdvcmQ+PGtleXdvcmQ+ZVFUTDwva2V5d29yZD48a2V5d29yZD5nZW5l
IG5ldHdvcms8L2tleXdvcmQ+PGtleXdvcmQ+Z2VuZSByZWd1bGF0aW9uPC9rZXl3b3JkPjxrZXl3
b3JkPmtpZG5leTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE3PC95ZWFyPjxw
dWItZGF0ZXM+PGRhdGU+SnVuIDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTM3
LTY2MDUgKEVsZWN0cm9uaWMpJiN4RDswMDAyLTkyOTcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np
b24tbnVtPjI4NTc1NjQ5PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o
dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yODU3NTY0OTwvdXJsPjwvcmVsYXRl
ZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM1NDczNzM1PC9jdXN0b20yPjxlbGVjdHJvbmljLXJl
c291cmNlLW51bT4xMC4xMDE2L2ouYWpoZy4yMDE3LjA1LjAwNDwvZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA 22, tubular and glomerularPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA 23 eQTL analyses have been described previously. Tubular and glomerular eQTL data sets were generated by 121 samples of tubules and 119 samples of glomeruli, respectivelyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO
dW0+NTE4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+MjM8
L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj41MTg8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJkenI1c3ZyMmt3dDJkNWV6OWVweDlw
eDZ4czUwNTl2OXp4YXYiIHRpbWVzdGFtcD0iMTU1OTMyNzc1MCI+NTE4PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5RaXUsIEMuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywg
Uy48L2F1dGhvcj48YXV0aG9yPlBhcmssIEouPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBZLjwvYXV0
aG9yPjxhdXRob3I+S28sIFkuIEEuPC9hdXRob3I+PGF1dGhvcj5TZWFzb2NrLCBNLiBKLjwvYXV0
aG9yPjxhdXRob3I+QnJ5ZXIsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5YdSwgWC4gWC48L2F1dGhv
cj48YXV0aG9yPlNvbmcsIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5QYWxtZXIsIE0uPC9hdXRob3I+
PGF1dGhvcj5IaWxsLCBKLjwvYXV0aG9yPjxhdXRob3I+R3Vhcm5pZXJpLCBQLjwvYXV0aG9yPjxh
dXRob3I+SGF3a2lucywgSi48L2F1dGhvcj48YXV0aG9yPkJvdXN0YW55LUthcmksIEMuIE0uPC9h
dXRob3I+PGF1dGhvcj5QdWxsZW4sIFMuIFMuPC9hdXRob3I+PGF1dGhvcj5Ccm93biwgQy4gRC48
L2F1dGhvcj48YXV0aG9yPlN1c3p0YWssIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0
b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgUmVuYWwgRWxlY3Ryb2x5
dGUgYW5kIEh5cGVydGVuc2lvbiBEaXZpc2lvbiwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEs
IFBoaWxhZGVscGhpYSwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgR2VuZXRpY3MsIFVuaXZl
cnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQZXJlbG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFBoaWxh
ZGVscGhpYSwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgQ2VsbCBCaW9sb2d5LCBTeWx2ZXN0
ZXIgQ29tcHJlaGVuc2l2ZSBDYW5jZXIgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIE1pYW1pIE1pbGxl
ciBTY2hvb2wgb2YgTWVkaWNpbmUsIE1pYW1pLCBGTCwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBT
eXN0ZW1zIFBoYXJtYWNvbG9neSBhbmQgVHJhbnNsYXRpb25hbCBUaGVyYXBldXRpY3MsIFBlcmVs
bWFuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCBVbml2ZXJzaXR5IG9mIFBlbm5zeWx2YW5pYSwgUGVu
bnN5bHZhbmlhLCBQQSwgVVNBLiYjeEQ7UGF0aG9sb2d5IGFuZCBMYWJvcmF0b3J5IE1lZGljaW5l
IGF0IHRoZSBIb3NwaXRhbCBvZiB0aGUgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxh
ZGVscGhpYSwgUEEsIFVTQS4mI3hEO0JvZWhyaW5nZXIgSW5nZWxoZWltIFBoYXJtYWNldXRpY2Fs
cywgSW5jLiwgUmlkZ2VmaWVsZCwgQ1QsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUs
IFJlbmFsIEVsZWN0cm9seXRlIGFuZCBIeXBlcnRlbnNpb24gRGl2aXNpb24sIFVuaXZlcnNpdHkg
b2YgUGVubnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBBLCBVU0EuIGtzdXN6dGFrQHBlbm5tZWRp
Y2luZS51cGVubi5lZHUuJiN4RDtEZXBhcnRtZW50IG9mIEdlbmV0aWNzLCBVbml2ZXJzaXR5IG9m
IFBlbm5zeWx2YW5pYSwgUGVyZWxtYW4gU2Nob29sIG9mIE1lZGljaW5lLCBQaGlsYWRlbHBoaWEs
IFBBLCBVU0EuIGtzdXN6dGFrQHBlbm5tZWRpY2luZS51cGVubi5lZHUuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+UmVuYWwgY29tcGFydG1lbnQtc3BlY2lmaWMgZ2VuZXRpYyB2YXJpYXRp
b24gYW5hbHlzZXMgaWRlbnRpZnkgbmV3IHBhdGh3YXlzIGluIGNocm9uaWMga2lkbmV5IGRpc2Vh
c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TmF0IE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5hdCBNZWQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp
Y2FsPjxwYWdlcz4xNzIxLTE3MzE8L3BhZ2VzPjx2b2x1bWU+MjQ8L3ZvbHVtZT48bnVtYmVyPjEx
PC9udW1iZXI+PGVkaXRpb24+MjAxOC8xMC8wMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+
QWRhcHRvciBQcm90ZWlucywgU2lnbmFsIFRyYW5zZHVjaW5nLypnZW5ldGljczwva2V5d29yZD48
a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkNlbGwgQ29tcGFydG1lbnRhdGlvbi9n
ZW5ldGljczwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVscywgQW5pbWFsPC9rZXl3b3Jk
PjxrZXl3b3JkPkdlbmUgRXhwcmVzc2lvbiBSZWd1bGF0aW9uL2dlbmV0aWNzPC9rZXl3b3JkPjxr
ZXl3b3JkPipHZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdv
cmQ+R2Vub21lLVdpZGUgQXNzb2NpYXRpb24gU3R1ZHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z
PC9rZXl3b3JkPjxrZXl3b3JkPktpZG5leS9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgR2xvbWVydWx1cy9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgVHVidWxlcywgUHJveGltYWwvbWV0YWJvbGlzbS9wYXRob2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+TWljZTwva2V5d29yZD48a2V5d29yZD5Qb2x5bW9ycGhpc20sIFNpbmds
ZSBOdWNsZW90aWRlL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YW50aXRhdGl2ZSBUcmFp
dCBMb2NpLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5SZW5hbCBJbnN1ZmZpY2llbmN5LCBD
aHJvbmljLypnZW5ldGljcy9waHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2lnbmFs
IFRyYW5zZHVjdGlvbi9nZW5ldGljczwva2V5d29yZD48a2V5d29yZD5UcmFuc2Zvcm1pbmcgR3Jv
d3RoIEZhY3RvciBiZXRhL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlR1bW9yIFN1cHByZXNz
b3IgUHJvdGVpbnMvKmdlbmV0aWNzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw
MTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
aXNibj4xNTQ2LTE3MFggKEVsZWN0cm9uaWMpJiN4RDsxMDc4LTg5NTYgKExpbmtpbmcpPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjMwMjc1NTY2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDI3NTU2NjwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2MzAxMDExPC9jdXN0b20yPjxlbGVj
dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3M0MTU5MS0wMTgtMDE5NC00PC9lbGVjdHJvbmlj
LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO
dW0+NTE4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+MjM8
L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj41MTg8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJkenI1c3ZyMmt3dDJkNWV6OWVweDlw
eDZ4czUwNTl2OXp4YXYiIHRpbWVzdGFtcD0iMTU1OTMyNzc1MCI+NTE4PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5RaXUsIEMuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywg
Uy48L2F1dGhvcj48YXV0aG9yPlBhcmssIEouPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBZLjwvYXV0
aG9yPjxhdXRob3I+S28sIFkuIEEuPC9hdXRob3I+PGF1dGhvcj5TZWFzb2NrLCBNLiBKLjwvYXV0
aG9yPjxhdXRob3I+QnJ5ZXIsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5YdSwgWC4gWC48L2F1dGhv
cj48YXV0aG9yPlNvbmcsIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5QYWxtZXIsIE0uPC9hdXRob3I+
PGF1dGhvcj5IaWxsLCBKLjwvYXV0aG9yPjxhdXRob3I+R3Vhcm5pZXJpLCBQLjwvYXV0aG9yPjxh
dXRob3I+SGF3a2lucywgSi48L2F1dGhvcj48YXV0aG9yPkJvdXN0YW55LUthcmksIEMuIE0uPC9h
dXRob3I+PGF1dGhvcj5QdWxsZW4sIFMuIFMuPC9hdXRob3I+PGF1dGhvcj5Ccm93biwgQy4gRC48
L2F1dGhvcj48YXV0aG9yPlN1c3p0YWssIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0
b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgUmVuYWwgRWxlY3Ryb2x5
dGUgYW5kIEh5cGVydGVuc2lvbiBEaXZpc2lvbiwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEs
IFBoaWxhZGVscGhpYSwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgR2VuZXRpY3MsIFVuaXZl
cnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQZXJlbG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFBoaWxh
ZGVscGhpYSwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgQ2VsbCBCaW9sb2d5LCBTeWx2ZXN0
ZXIgQ29tcHJlaGVuc2l2ZSBDYW5jZXIgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIE1pYW1pIE1pbGxl
ciBTY2hvb2wgb2YgTWVkaWNpbmUsIE1pYW1pLCBGTCwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBT
eXN0ZW1zIFBoYXJtYWNvbG9neSBhbmQgVHJhbnNsYXRpb25hbCBUaGVyYXBldXRpY3MsIFBlcmVs
bWFuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCBVbml2ZXJzaXR5IG9mIFBlbm5zeWx2YW5pYSwgUGVu
bnN5bHZhbmlhLCBQQSwgVVNBLiYjeEQ7UGF0aG9sb2d5IGFuZCBMYWJvcmF0b3J5IE1lZGljaW5l
IGF0IHRoZSBIb3NwaXRhbCBvZiB0aGUgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxh
ZGVscGhpYSwgUEEsIFVTQS4mI3hEO0JvZWhyaW5nZXIgSW5nZWxoZWltIFBoYXJtYWNldXRpY2Fs
cywgSW5jLiwgUmlkZ2VmaWVsZCwgQ1QsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUs
IFJlbmFsIEVsZWN0cm9seXRlIGFuZCBIeXBlcnRlbnNpb24gRGl2aXNpb24sIFVuaXZlcnNpdHkg
b2YgUGVubnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBBLCBVU0EuIGtzdXN6dGFrQHBlbm5tZWRp
Y2luZS51cGVubi5lZHUuJiN4RDtEZXBhcnRtZW50IG9mIEdlbmV0aWNzLCBVbml2ZXJzaXR5IG9m
IFBlbm5zeWx2YW5pYSwgUGVyZWxtYW4gU2Nob29sIG9mIE1lZGljaW5lLCBQaGlsYWRlbHBoaWEs
IFBBLCBVU0EuIGtzdXN6dGFrQHBlbm5tZWRpY2luZS51cGVubi5lZHUuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+UmVuYWwgY29tcGFydG1lbnQtc3BlY2lmaWMgZ2VuZXRpYyB2YXJpYXRp
b24gYW5hbHlzZXMgaWRlbnRpZnkgbmV3IHBhdGh3YXlzIGluIGNocm9uaWMga2lkbmV5IGRpc2Vh
c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TmF0IE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5hdCBNZWQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp
Y2FsPjxwYWdlcz4xNzIxLTE3MzE8L3BhZ2VzPjx2b2x1bWU+MjQ8L3ZvbHVtZT48bnVtYmVyPjEx
PC9udW1iZXI+PGVkaXRpb24+MjAxOC8xMC8wMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+
QWRhcHRvciBQcm90ZWlucywgU2lnbmFsIFRyYW5zZHVjaW5nLypnZW5ldGljczwva2V5d29yZD48
a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkNlbGwgQ29tcGFydG1lbnRhdGlvbi9n
ZW5ldGljczwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVscywgQW5pbWFsPC9rZXl3b3Jk
PjxrZXl3b3JkPkdlbmUgRXhwcmVzc2lvbiBSZWd1bGF0aW9uL2dlbmV0aWNzPC9rZXl3b3JkPjxr
ZXl3b3JkPipHZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdv
cmQ+R2Vub21lLVdpZGUgQXNzb2NpYXRpb24gU3R1ZHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z
PC9rZXl3b3JkPjxrZXl3b3JkPktpZG5leS9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgR2xvbWVydWx1cy9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgVHVidWxlcywgUHJveGltYWwvbWV0YWJvbGlzbS9wYXRob2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+TWljZTwva2V5d29yZD48a2V5d29yZD5Qb2x5bW9ycGhpc20sIFNpbmds
ZSBOdWNsZW90aWRlL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YW50aXRhdGl2ZSBUcmFp
dCBMb2NpLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5SZW5hbCBJbnN1ZmZpY2llbmN5LCBD
aHJvbmljLypnZW5ldGljcy9waHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2lnbmFs
IFRyYW5zZHVjdGlvbi9nZW5ldGljczwva2V5d29yZD48a2V5d29yZD5UcmFuc2Zvcm1pbmcgR3Jv
d3RoIEZhY3RvciBiZXRhL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlR1bW9yIFN1cHByZXNz
b3IgUHJvdGVpbnMvKmdlbmV0aWNzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw
MTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
aXNibj4xNTQ2LTE3MFggKEVsZWN0cm9uaWMpJiN4RDsxMDc4LTg5NTYgKExpbmtpbmcpPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjMwMjc1NTY2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDI3NTU2NjwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2MzAxMDExPC9jdXN0b20yPjxlbGVj
dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3M0MTU5MS0wMTgtMDE5NC00PC9lbGVjdHJvbmlj
LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA 23. The cis window was defined as 1 megabase up- and down-stream of the transcriptional start site (±1Mb). Whole kidney cis-eQTL (further just referred to as eQTL) data set was generated from 96 human samples obtained from The Cancer Genome Atlas (TCGA) through the TCGA Data portalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA 22. Mouse kidney single cell RNA-sequencing. Kidneys were harvested from 4 to 8-week-old male mice with C57BL/6 background and dissociated into single cell suspension as described in our previous studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj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 EN.CITE.DATA 24. The single cell sequencing libraries were sequenced on an Illumina HiSeq with 2x150 paired-end kit. The sequencing reads were demultiplexed, aligned to the mouse genome (mm10) and processed to generate gene-cell data matrix using Cell Ranger 1.3 ()PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj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 EN.CITE.DATA 24.Genomic features of human kidney. Human kidney-specific chromatin immunoprecipitation followed by sequencing (ChIP-seq) data can be found at GEO: GSM621634, GSM670025, GSM621648, GSM772811, GSM621651, GSM1112806, GSM621638. Different histone markers were combined into chromatin states using ChromHMM ADDIN EN.CITE <EndNote><Cite><Author>Bernstein</Author><Year>2010</Year><RecNum>525</RecNum><DisplayText><style face="superscript">25</style></DisplayText><record><rec-number>525</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1560792968">525</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bernstein, B. E.</author><author>Stamatoyannopoulos, J. A.</author><author>Costello, J. F.</author><author>Ren, B.</author><author>Milosavljevic, A.</author><author>Meissner, A.</author><author>Kellis, M.</author><author>Marra, M. A.</author><author>Beaudet, A. L.</author><author>Ecker, J. R.</author><author>Farnham, P. J.</author><author>Hirst, M.</author><author>Lander, E. S.</author><author>Mikkelsen, T. S.</author><author>Thomson, J. A.</author></authors></contributors><auth-address>Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Bernstein.Bradley@mgh.harvard.edu</auth-address><titles><title>The NIH Roadmap Epigenomics Mapping Consortium</title><secondary-title>Nat Biotechnol</secondary-title></titles><periodical><full-title>Nat Biotechnol</full-title></periodical><pages>1045-8</pages><volume>28</volume><number>10</number><edition>2010/10/15</edition><keywords><keyword>*Cooperative Behavior</keyword><keyword>*Epigenomics</keyword><keyword>Genome, Human/genetics</keyword><keyword>Humans</keyword><keyword>*National Institutes of Health (U.S.)</keyword><keyword>Reference Standards</keyword><keyword>Stem Cells/metabolism</keyword><keyword>United States</keyword></keywords><dates><year>2010</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1546-1696 (Electronic)
1087-0156 (Linking)</isbn><accession-num>20944595</accession-num><urls><related-urls><url> and gene set analysis. PASCAL and MAGMA (v1.06) gene and pathway scores were conducted on all 20 sets of GWAS summary statistics using default pathway libraries from BioCarta, REACTOME, and KEGG. MAGENTA (vs2, July 2011) pathway analysis included 4725 pathways with a minimum of five genes within the gene set for the 10 standard adjustment models. We conducted DEPICT individually on all 20 sets of GWAS summary statistics with P<10-5 and additional pooled analyses using genome-wide minimum P-values from: 1) All 20 analyses (10 phenotypes and 2 covariate models) and 2) 16 analyses of the 8 most related phenotypes which excluded ESRD vs Macro and Micro. Transcriptome-wide association study (TWAS): TWAS of kidney glomeruli and tubuli was performed using MetaXcan with default parameters,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJiZWlyYTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJiZWlyYTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+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ADDIN EN.CITE.DATA 26 based on eQTL data for human glomerular and tubular cells.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA 23RESULTSPhenotypic comparisonsWe investigated a broad spectrum of DKD definitions based on albuminuria and renal function criteria, defining a total of 10 different case-control comparisons to cover the different aspects of disease progression (Figure 1). Seven comparisons were based on albuminuria and/or ESRD (including diabetic nephropathy [DN], defined as either macroalbuminuria or ESRD); two were defined based on eGFR (used to classify severity of chronic kidney disease [CKD]); and one combined both albuminuria and eGFR data (“CKD-DN”). Each phenotypic definition was analyzed separately in GWAS; to account for the 10 definitions each analyzed under two covariate adjustment models, we estimated ADDIN EN.CITE <EndNote><Cite><Author>Li</Author><Year>2005</Year><RecNum>20</RecNum><DisplayText><style face="superscript">16</style></DisplayText><record><rec-number>20</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542677109">20</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Li, J.</author><author>Ji, L.</author></authors></contributors><auth-address>The Ministry of Education (MOE) Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, People's Republic of China.</auth-address><titles><title>Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix</title><secondary-title>Heredity (Edinb)</secondary-title></titles><periodical><full-title>Heredity (Edinb)</full-title></periodical><pages>221-7</pages><volume>95</volume><number>3</number><edition>2005/08/04</edition><keywords><keyword>*Data Interpretation, Statistical</keyword><keyword>*Genetic Predisposition to Disease</keyword><keyword>Genetic Testing/*methods</keyword><keyword>Genetics, Medical/*methods</keyword><keyword>*Models, Genetic</keyword><keyword>*Research Design</keyword></keywords><dates><year>2005</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0018-067X (Print)
0018-067X (Linking)</isbn><accession-num>16077740</accession-num><urls><related-urls><url> the total effectively independent tests as 7.4, allowing us to compute a more conservative study-wide significance threshold (P<6.76×10-9), based on genome-wide significance (P<5×10-8) and Bonferroni correction for 7.4 effective genome-wide association results highlight COL4A3GWAS meta-analysis included association results for up to 19,406 individuals with T1D of European descent from 17 cohorts for the 10 case-control definitions (Table S1). We identified 16 novel independent loci that achieved genome-wide significance (P<5×10-8) in either the minimal or fully adjusted models, in which four lead SNPs also surpassed our more conservative study-wide significance threshold (Table 1; Figure 2, Manhattan plot; Figures S2a-p, regional association and forest plots). None of the loci reaching genome-wide significance have been previously identified in GWAS or candidate gene studies for DKD or closely related traits. All SNPs with minor allele frequency greater than 1% explain 2.5% and 3.0% of the total variance (McKelvey-Zavoina ADDIN EN.CITE <EndNote><Cite><Author>McKelvey</Author><Year>1975</Year><RecNum>515</RecNum><DisplayText><style face="superscript">17</style></DisplayText><record><rec-number>515</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1559260861">515</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>McKelvey, Richard D.</author><author>Zavoina, William</author></authors></contributors><titles><title>A statistical model for the analysis of ordinal level dependent variables</title><secondary-title>The Journal of Mathematical Sociology</secondary-title></titles><periodical><full-title>The Journal of Mathematical Sociology</full-title></periodical><pages>103-120</pages><volume>4</volume><number>1</number><dates><year>1975</year><pub-dates><date>1975/01/01</date></pub-dates></dates><publisher>Routledge</publisher><isbn>0022-250X</isbn><urls><related-urls><url> pseudo-R2) of DN after adjusting for covariates in the minimal and full covariate models, respectively (Table S12). The strongest signal was rs55703767 (minor allele frequency [MAF]=0.21), a common missense variant (G>T; Asp326Tyr) in exon 17 of COL4A3. This SNP was associated with protection from DN (odds ratio [OR]=0.79, P=5.34×10-12), any albuminuria (OR=0.84, P=3.88×10-10), the combined CKD-DN phenotype (OR =0.77, P=5.30×10-9), and macroalbuminuria (OR=0.79, P=9.28×10-9). Interestingly, we found that rs55703767 in COL4A3 was more strongly associated in men (OR=0.73, P=1.29×10-11) than in women (OR=0.85, P=1.39×10-3; Phet=1.58×10-2). COL4A3 encodes the alpha 3 chain of collagen type IV, a major structural component of the GBM ADDIN EN.CITE <EndNote><Cite><Author>Yagame</Author><Year>1995</Year><RecNum>17</RecNum><DisplayText><style face="superscript">27</style></DisplayText><record><rec-number>17</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542676909">17</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yagame, M.</author><author>Kim, Y.</author><author>Zhu, D.</author><author>Suzuki, D.</author><author>Eguchi, K.</author><author>Nomoto, Y.</author><author>Sakai, H.</author><author>Groppoli, T.</author><author>Steffes, M. W.</author><author>Mauer, S. M.</author></authors></contributors><auth-address>Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan.</auth-address><titles><title>Differential distribution of type IV collagen chains in patients with diabetic nephropathy in non-insulin-dependent diabetes mellitus</title><secondary-title>Nephron</secondary-title></titles><periodical><full-title>Nephron</full-title></periodical><pages>42-8</pages><volume>70</volume><number>1</number><edition>1995/01/01</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Biopsy</keyword><keyword>Collagen/*metabolism</keyword><keyword>Diabetes Mellitus, Type 2/complications/*metabolism/pathology</keyword><keyword>Diabetic Nephropathies/etiology/*metabolism/pathology</keyword><keyword>Extracellular Matrix/*metabolism/ultrastructure</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Immunohistochemistry</keyword><keyword>Male</keyword><keyword>Microscopy, Electron</keyword><keyword>Microscopy, Fluorescence</keyword><keyword>Middle Aged</keyword></keywords><dates><year>1995</year></dates><isbn>1660-8151 (Print)
1660-8151 (Linking)</isbn><accession-num>7617116</accession-num><urls><related-urls><url>. COL4A3 variation and kidney phenotypesIn persons with T1D and normoalbuminuria, GBM width predicts progression to proteinuria and ESRD independently of glycated hemoglobin (HbA1c) ADDIN EN.CITE <EndNote><Cite><Author>Caramori</Author><Year>2013</Year><RecNum>78</RecNum><DisplayText><style face="superscript">28</style></DisplayText><record><rec-number>78</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542682697">78</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Caramori, M. L.</author><author>Parks, A.</author><author>Mauer, M.</author></authors></contributors><auth-address>Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. caram001@umn.edu</auth-address><titles><title>Renal lesions predict progression of diabetic nephropathy in type 1 diabetes</title><secondary-title>J Am Soc Nephrol</secondary-title></titles><periodical><full-title>J Am Soc Nephrol</full-title><abbr-1>Journal of the American Society of Nephrology : JASN</abbr-1></periodical><pages>1175-81</pages><volume>24</volume><number>7</number><edition>2013/05/21</edition><keywords><keyword>Adult</keyword><keyword>Albuminuria/pathology</keyword><keyword>Biopsy</keyword><keyword>Diabetes Mellitus, Type 1/*pathology/physiopathology</keyword><keyword>Diabetic Nephropathies/*pathology/physiopathology</keyword><keyword>*Disease Progression</keyword><keyword>Female</keyword><keyword>Follow-Up Studies</keyword><keyword>Glomerular Basement Membrane/pathology</keyword><keyword>Humans</keyword><keyword>Kidney/*pathology</keyword><keyword>Kidney Glomerulus/pathology</keyword><keyword>Logistic Models</keyword><keyword>Male</keyword><keyword>Survival Rate</keyword></keywords><dates><year>2013</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1533-3450 (Electronic)
1046-6673 (Linking)</isbn><accession-num>23687360</accession-num><urls><related-urls><url>. We examined the influence of the COL4A3 variant on GBM width in 253 RASSPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXVlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXVlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJl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ADDIN EN.CITE.DATA 18 participants with T1D and normal AER, eGFR (>90 ml/min/1.73 m2) and blood pressure, who had biopsy and genetic data (Table S2). The DKD-protective minor T allele was associated with 19.7 nm lower GBM width (standard error (SE) 8.2 nm, P=0.02), with the lowest mean GBM width among TT homozygotes (Figure 3; Table S3), after adjusting for age, sex, and diabetes duration, and without detectable interactions with T1D duration or mean HbA1c. Thus, the protective T allele carriers had thinner GBM prior to any renal complications. We did not detect any eQTL association between rs55703767 and COL4A3 expression in mouse glomeruli or in human tissues, and thus assume that the variant affects the COL4A3 structure rather than expression levels. Nevertheless in a Pima Indian cohort of 97 subjects with DKD with morphometric and expression data from renal biopsies, COL4A3 expression was negatively correlated with the GBM surface density (filtration surface density) (β=-0.27, P=0.02), which is associated with eGFR in DKD in both T1D and T2DPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GdWZhYTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GdWZhYTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl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ADDIN EN.CITE.DATA 29,30. Furthermore, in 335 micro-dissected human glomerulus samples, expression of COL4A3 was negatively correlated with glomerulosclerosis, potentially reflecting podocyte depletion in sclerotic glomeruli (corr=0.16, P=4.8×10-3; Figure S3). COL4A3 expression in glomeruli, but not in tubules, was also nominally correlated with eGFR (corr 0.108, P=0.047; Figure S3).Evidence for hyperglycemia specificityHyperglylcemia promotes the development of diabetic complications. If a genetic variant exerts a stronger effect in the setting of hyperglycemia, 1) it might not be detected in general CKD, 2) it may be detected whether hyperglycemia is conferred by T1D or T2D, 3) its effect may be stronger at higher glycemic strata, and 4) interventions that reduce glycemia may attenuate the association signal. COL4A3 rs55703767 was not associated with eGFR in a general population sample of 110,517 mainly non-diabetic participants of European ancestryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb3Jza2k8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb3Jza2k8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 31 (Table S4). However, in a smaller cohort of 5,190 participants with T2D and DKD phenotypes in the SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) consortium, we detected a directionally consistent suggestive association of COL4A3 rs55703767 with DN (2-tailed P=0.08; Table S5). We further stratified the association analyses by HbA1c in the Finnish Diabetic Nephropathy (FinnDiane) Study, a T1D cohort study with extensive longitudinal phenotypic data ADDIN EN.CITE <EndNote><Cite><Author>Thorn</Author><Year>2005</Year><RecNum>46</RecNum><DisplayText><style face="superscript">32</style></DisplayText><record><rec-number>46</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1336701055">46</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Thorn, Lena M.</author><author>Forsblom, Carol</author><author>Fagerudd, Johan</author><author>Thomas, Merlin C.</author><author>Pettersson-Fernholm, Kim</author><author>Saraheimo, Markku</author><author>Waden, Johan</author><author>Ronnback, Mats</author><author>Rosengard-Barlund, Milla</author><author>Bjorkesten, Clas-Goran af</author><author>Taskinen, Marja-Riitta</author><author>Groop, Per-Henrik</author><author>on behalf of the FinnDiane Study Group,</author></authors></contributors><titles><title>Metabolic syndrome in type 1 diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study)</title><secondary-title>Diabetes Care</secondary-title><alt-title>Diabetes Care</alt-title></titles><periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes Care</abbr-1></periodical><alt-periodical><full-title>Diabetes Care</full-title><abbr-1>Diabetes Care</abbr-1></alt-periodical><pages>2019-2024</pages><volume>28</volume><number>8</number><dates><year>2005</year><pub-dates><date>August 1, 2005</date></pub-dates></dates><urls><related-urls><url>. Based on the time-weighted mean of all available HbA1c measurements for each individual, 1,344 individuals had mean HbA1c <7.5% (58 mmol/mol), and 2,977 with mean HbA1c ≥7.5%. COL4A3 rs55703767 was nominally significant (P<0.05) only in individuals with HbA1c ≥7.5% (Figure 4, Table S6, Figure S4). However, the interaction between HbA1c and COL4A3 rs55703767 was not significant (P=0.83). Upon further examination, the genetic effect was diminished also in the highest HbA1c quartile (>9.3%), as the environmental effect of HbA1c seems to overwhelm any potential genetic effects at COL4A3 (test of heterogeneity non-significant). In a similar setting of individuals with T2D from the GoDARTS study (N=3226)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXM8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JyaXM8L0F1dGhvcj48WWVhcj4xOTk3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 13,33, no difference was observed for COL4A3 rs55703767 between HbA1c strata below or above 7.5% (Figure S5). We performed a similar HbA1c stratified analysis in the Diabetes Control and Complications Trial (DCCT), whose participants, all with T1D, continue to be followed in the Epidemiology of Diabetes Interventions and Complications (EDIC)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRoYW48L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRoYW48L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 34,35. In DCCT-EDIC the effect of COL4A3 rs55703767 was stronger among those recruited in the secondary cohort (mild retinopathy and longer diabetes duration at baseline) who were originally randomized to conventional treatment and therefore had higher HbA1c than the intensive treatment group (Table S7). Taken together, these independent lines of evidence strongly suggest that the COL4A3 variant effect on DKD risk is amplified by poor glycemic control.Other association signalsA comprehensive list of all loci that achieved genome-wide significance from either the minimal or the fully adjusted covariate models is reported in Table 1. The fewer covariates required for the minimal model results in improved statistical power due to fewer subjects with missing data, whereas the fully adjusted model allows the identification of associations potentially mediated by covariates. Comparison of the adjustment models revealed strong consistency between the two models (Figure S6). Table 1 is stratified into two sets of loci: common and/or known kidney biology loci (top half, n=8) and uncommon and no known kidney biology loci (bottom half, n=8). We focus on loci in the top half of the table, common and/or in/near genes with relevant kidney biology. Two other genome-wide significant signals were near genes encoding proteins related to collagen. Variant rs12615970 (MAF=0.13), located 53 kb downstream of COLEC11, was associated with CKD (OR=1.31, P=9.43×10-9), and rs116772905 (MAF=0.011) in exon 14 of DDR1 was associated with microalbuminuria (OR=3.78, P=4.40×10-8). rs116772905 is in perfect linkage disequilibrium with rs118124843, the lead association with microalbuminuria for this locus under the full adjustment model (taking into account both BMI and HbA1c), located 29 kb downstream of DDR1 (OR=3.97, P=3.37×10-8). COLEC11 encodes a collectin protein containing both a collagen-like domain and a carbohydrate recognition domain for binding sugars, and DDR1 encodes the discoidin domain-containing receptor 1, which binds collagens including type IV collagen.In addition to COL4A3 rs55703767, three other low-frequency variants achieved study-wide significance (P<6.76×10-9), each associated with microalbuminuria: rs142823282 (MAF=0.017), 22 kb upstream of TAMM41 encoding a mitochondrial translocator assembly and maintenance proteinPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbHVuc29tPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbHVuc29tPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48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ADDIN EN.CITE.DATA 36,37 (OR=6.75, P=1.13×10-11), rs144434404 (MAF=0.011), in intron 1 of BMP7 encoding the bone morphogenetic protein 7 previously implicated in DKDPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 38 (OR=6.75, P=2.67×10-9), and rs145681168 (MAF=0.014), in intron 3 of two transcripts of HAND2 antisense RNA 1 (HAND2-AS1; OR=5.53, P=5.40×10-9) and 50 kb upstream of HAND2, encoding a heart and neural crest derivatives transcription factor. Two additional common variants achieved genome-wide significance: rs551191707 (MAF=0.122) in PRNCR1 associated with ESRD when compared with macroalbuminuria (OR=1.70, P=4.39×10-8) and rs61983410 (MAF=0.213) in an intergenic region on chromosome 14 associated with microalbuminuria (full model OR=0.78, P=3.06×10-8). The remaining seven variants associated with features of DKD had lower allele frequencies (four with 0.01≤MAF≤0.05 and four with MAF<0.01) and did not achieve study-wide significance. As we had done for COL4A3 rs55703767, we tested whether the associations of the 15 other variants were amplified by hyperglycemia. None of the 15 variants were significantly associated with eGFR in the general population (Table S4). In the smaller SUMMIT T2D cohortPEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gWnV5ZGFtPC9BdXRob3I+PFllYXI+MjAxODwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gWnV5ZGFtPC9BdXRob3I+PFllYXI+MjAxODwvWWVh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ADDIN EN.CITE.DATA 13 we were able to interrogate seven loci with comparable trait definitions. The odds ratios were directionally consistent in six of them (binomial sign test: P=0.0625, Table S5). In FinnDiane seven of the remaining 15 loci were observed with sufficient frequency (minor allele counts >10) to allow subgroup analysis. Two additional SNPs (rs149641852 in SNCAIP and rs12615970 near COLEC11) were nominally significant (P<0.05) only in individuals with HbA1c ≥7.5%, however the genotype × HbA1c interaction term was non-significant (Table S6, Figure S4).Variants previously associated with DKD We investigated the effect of variants previously associated at genome-wide significance with renal complications in individuals with diabetesQS4mI3hEO1ZhbmRlcmJpbHQgVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIDQ0OCBFc2tp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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JeWVuZ2FyPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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==
ADDIN EN.CITE.DATA QS4mI3hEO1ZhbmRlcmJpbHQgVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIDQ0OCBFc2tp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=
ADDIN EN.CITE.DATA 8-13,39. Across the ten sub-phenotypes in our meta-analysis, we found evidence of association for seven of nine examined loci (P<0.05, Figure S7): We replicated two loci that were previously discovered without overlapping individuals with the current study: SCAF8/CNKSR3 rs12523822, originally associated with DKD (P=6.8×10-4 for “All vs ctrl”) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JeWVuZ2FyPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjQ1ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi
Pjg8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40NTg8L3JlYy1udW1i
ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJkenI1c3ZyMmt3dDJkNWV6OWVw
eDlweDZ4czUwNTl2OXp4YXYiIHRpbWVzdGFtcD0iMTUwNzg2MDE3MSI+NDU4PC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5JeWVuZ2FyLCBTLiBLLjwvYXV0aG9yPjxhdXRo
b3I+U2Vkb3IsIEouIFIuPC9hdXRob3I+PGF1dGhvcj5GcmVlZG1hbiwgQi4gSS48L2F1dGhvcj48
YXV0aG9yPkthbywgVy4gSC48L2F1dGhvcj48YXV0aG9yPktyZXR6bGVyLCBNLjwvYXV0aG9yPjxh
dXRob3I+S2VsbGVyLCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+QWJib3VkLCBILiBFLjwvYXV0aG9y
PjxhdXRob3I+QWRsZXIsIFMuIEcuPC9hdXRob3I+PGF1dGhvcj5CZXN0LCBMLiBHLjwvYXV0aG9y
PjxhdXRob3I+Qm93ZGVuLCBELiBXLjwvYXV0aG9yPjxhdXRob3I+QnVybG9jaywgQS48L2F1dGhv
cj48YXV0aG9yPkNoZW4sIFkuIEQuPC9hdXRob3I+PGF1dGhvcj5Db2xlLCBTLiBBLjwvYXV0aG9y
PjxhdXRob3I+Q29tZWF1LCBNLiBFLjwvYXV0aG9yPjxhdXRob3I+Q3VydGlzLCBKLiBNLjwvYXV0
aG9yPjxhdXRob3I+RGl2ZXJzLCBKLjwvYXV0aG9yPjxhdXRob3I+RHJlY2hzbGVyLCBDLjwvYXV0
aG9yPjxhdXRob3I+RHVnZ2lyYWxhLCBSLjwvYXV0aG9yPjxhdXRob3I+RWxzdG9uLCBSLiBDLjwv
YXV0aG9yPjxhdXRob3I+R3VvLCBYLjwvYXV0aG9yPjxhdXRob3I+SHVhbmcsIEguPC9hdXRob3I+
PGF1dGhvcj5Ib2ZmbWFubiwgTS4gTS48L2F1dGhvcj48YXV0aG9yPkhvd2FyZCwgQi4gVi48L2F1
dGhvcj48YXV0aG9yPklwcCwgRS48L2F1dGhvcj48YXV0aG9yPktpbW1lbCwgUC4gTC48L2F1dGhv
cj48YXV0aG9yPktsYWcsIE0uIEouPC9hdXRob3I+PGF1dGhvcj5Lbm93bGVyLCBXLiBDLjwvYXV0
aG9yPjxhdXRob3I+S29obiwgTy4gRi48L2F1dGhvcj48YXV0aG9yPkxlYWssIFQuIFMuPC9hdXRo
b3I+PGF1dGhvcj5MZWVoZXksIEQuIEouPC9hdXRob3I+PGF1dGhvcj5MaSwgTS48L2F1dGhvcj48
YXV0aG9yPk1hbGhvdHJhLCBBLjwvYXV0aG9yPjxhdXRob3I+TWFyeiwgVy48L2F1dGhvcj48YXV0
aG9yPk5haXIsIFYuPC9hdXRob3I+PGF1dGhvcj5OZWxzb24sIFIuIEcuPC9hdXRob3I+PGF1dGhv
cj5OaWNob2xhcywgUy4gQi48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztCcmllbiwgUy4gSi48L2F1
dGhvcj48YXV0aG9yPlBhaGwsIE0uIFYuPC9hdXRob3I+PGF1dGhvcj5QYXJla2gsIFIuIFMuPC9h
dXRob3I+PGF1dGhvcj5QZXp6b2xlc2ksIE0uIEcuPC9hdXRob3I+PGF1dGhvcj5SYXNvb2x5LCBS
LiBTLjwvYXV0aG9yPjxhdXRob3I+Um90aW1pLCBDLiBOLjwvYXV0aG9yPjxhdXRob3I+Um90dGVy
LCBKLiBJLjwvYXV0aG9yPjxhdXRob3I+U2NoZWxsaW5nLCBKLiBSLjwvYXV0aG9yPjxhdXRob3I+
U2VsZGluLCBNLiBGLjwvYXV0aG9yPjxhdXRob3I+U2hhaCwgVi4gTy48L2F1dGhvcj48YXV0aG9y
PlNtaWxlcywgQS4gTS48L2F1dGhvcj48YXV0aG9yPlNtaXRoLCBNLiBXLjwvYXV0aG9yPjxhdXRo
b3I+VGF5bG9yLCBLLiBELjwvYXV0aG9yPjxhdXRob3I+VGhhbWVlbSwgRi48L2F1dGhvcj48YXV0
aG9yPlRob3JubGV5LUJyb3duLCBELiBQLjwvYXV0aG9yPjxhdXRob3I+VHJ1aXR0LCBCLiBKLjwv
YXV0aG9yPjxhdXRob3I+V2FubmVyLCBDLjwvYXV0aG9yPjxhdXRob3I+V2VpbCwgRS4gSi48L2F1
dGhvcj48YXV0aG9yPldpbmtsZXIsIEMuIEEuPC9hdXRob3I+PGF1dGhvcj5aYWdlciwgUC4gRy48
L2F1dGhvcj48YXV0aG9yPklnbywgUi4gUC4sIEpyLjwvYXV0aG9yPjxhdXRob3I+SGFuc29uLCBS
LiBMLjwvYXV0aG9yPjxhdXRob3I+TGFuZ2VmZWxkLCBDLiBELjwvYXV0aG9yPjxhdXRob3I+RmFt
aWx5IEludmVzdGlnYXRpb24gb2YsIE5lcGhyb3BhdGh5PC9hdXRob3I+PGF1dGhvcj5EaWFiZXRl
cyw8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt
ZW50IG9mIEVwaWRlbWlvbG9neSAmYW1wOyBCaW9zdGF0aXN0aWNzLCBDYXNlIFdlc3Rlcm4gUmVz
ZXJ2ZSBVbml2ZXJzaXR5LCBDbGV2ZWxhbmQsIE9oaW8sIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmlj
YS4mI3hEO0RlcGFydG1lbnRzIG9mIE1lZGljaW5lLCBDYXNlIFdlc3Rlcm4gUmVzZXJ2ZSBVbml2
ZXJzaXR5LCBDbGV2ZWxhbmQsIE9oaW8sIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYTsgRGVwYXJ0
bWVudHMgb2YgUGh5c2lvbG9neSBhbmQgQmlvcGh5c2ljcywgQ2FzZSBXZXN0ZXJuIFJlc2VydmUg
VW5pdmVyc2l0eSwgQ2xldmVsYW5kLCBPaGlvLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4
RDtEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBTZWN0aW9uIG9uIE5lcGhyb2xvZ3ks
IFdha2UgRm9yZXN0IFNjaG9vbCBvZiBNZWRpY2luZSwgV2luc3Rvbi1TYWxlbSwgTm9ydGggQ2Fy
b2xpbmEsIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYS4mI3hEO0RlcGFydG1lbnQgb2YgRXBpZGVt
aW9sb2d5IGFuZCBNZWRpY2luZSwgSm9obiBIb3BraW5zIFVuaXZlcnNpdHksIEJhbHRpbW9yZSwg
TWFyeWxhbmQsIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYS4mI3hEO0RlcGFydG1lbnQgb2YgSW50
ZXJuYWwgTWVkaWNpbmUvTmVwaHJvbG9neSwgVW5pdmVyc2l0eSBvZiBNaWNoaWdhbiwgQW5uIEFy
Ym9yLCBNaWNoaWdhbiwgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7RGVwYXJ0bWVudCBv
ZiBNZWRpY2luZS9OZXBocm9sb2d5LCBUaGUgVW5pdmVyc2l0eSBvZiBUZXhhcyBIZWFsdGggU2Np
ZW5jZSBDZW50ZXIsIFNhbiBBbnRvbmlvLCBUZXhhcywgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNh
LiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgRGl2aXNpb24gb2YgTmVwaHJvbG9neSBhbmQg
SHlwZXJ0ZW5zaW9uLCBIYXJib3ItVUNMQSBNZWRpY2FsIENlbnRlciwgVG9ycmFuY2UsIENhbGlm
b3JuaWEsIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYS4mI3hEO01pc3NvdXJpIEJyZWFrcyBJbmR1
c3RyaWVzIFJlc2VhcmNoLCBUaW1iZXIgTGFrZSwgU291dGggRGFrb3RhLCBVbml0ZWQgU3RhdGVz
IG9mIEFtZXJpY2EuJiN4RDtEZXBhcnRtZW50IG9mIEJpb2NoZW1pc3RyeSwgQ2VudGVyIGZvciBI
dW1hbiBHZW5vbWljcywgV2FrZSBGb3Jlc3QgU2Nob29sIG9mIE1lZGljaW5lLCBXaW5zdG9uLVNh
bGVtLCBOb3J0aCBDYXJvbGluYSwgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7VGhlIElu
c3RpdHV0ZSBmb3IgVHJhbnNsYXRpb25hbCBHZW5vbWljcyBhbmQgUG9wdWxhdGlvbiBTY2llbmNl
cywgSGFyYm9yLVVDTEEgTWVkaWNhbCBDZW50ZXIsIFRvcnJhbmNlLCBDYWxpZm9ybmlhLCBVbml0
ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4RDtEZXBhcnRtZW50IG9mIEdlbmV0aWNzLCBUZXhhcyBC
aW9tZWRpY2FsIFJlc2VhcmNoIEluc3RpdHV0ZSwgU2FuIEFudG9uaW8sIFRleGFzLCBVbml0ZWQg
U3RhdGVzIG9mIEFtZXJpY2EuJiN4RDtDZW50ZXIgZm9yIFB1YmxpYyBIZWFsdGggR2Vub21pY3Mg
YW5kIERlcGFydG1lbnQgb2YgQmlvc3RhdGlzdGljYWwgU2NpZW5jZXMsIERpdmlzaW9uIG9mIFB1
YmxpYyBIZWFsdGggU2NpZW5jZXMsIFdha2UgRm9yZXN0IFNjaG9vbCBvZiBNZWRpY2luZSwgV2lu
c3Rvbi1TYWxlbSwgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7TmF0aW9uYWwgSW5zdGl0
dXRlcyBvZiBEaWFiZXRlcyBhbmQgRGlnZXN0aXZlIGFuZCBLaWRuZXkgRGlzZWFzZXMsIE5hdGlv
bmFsIEluc3RpdHV0ZXMgb2YgSGVhbHRoLCBQaG9lbml4LCBBcml6b25hLCBVbml0ZWQgU3RhdGVz
IG9mIEFtZXJpY2EuJiN4RDtVbml2ZXJzaXR5IEhvc3BpdGFsIFd1cnpidXJnLCBSZW5hbCBEaXZp
c2lvbiBhbmQgQ29tcHJlaGVuc2l2ZSBIZWFydCBGYWlsdXJlIENlbnRlciwgV3VyemJ1cmcsIEdl
cm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIEVjb2xvZ3kgYW5kIEV2b2x1dGlvbmFyeSBCaW9sb2d5
LCBVbml2ZXJzaXR5IG9mIE1pY2hpZ2FuLCBBbm4gQXJib3IsIE1pY2hpZ2FuLCBVbml0ZWQgU3Rh
dGVzIG9mIEFtZXJpY2EuJiN4RDtEZXBhcnRtZW50IG9mIENsaW5pY2FsIENoZW1pc3RyeSwgVW5p
dmVyc2l0eSBNZWRpY2FsIENlbnRlciwgRnJlaWJ1cmcsIEdlcm1hbnkuJiN4RDtNZWRTdGFyIEhl
YWx0aCBSZXNlYXJjaCBJbnN0aXR1dGUsIEh5YXR0c3ZpbGxlLCBNYXJ5bGFuZCwgVW5pdGVkIFN0
YXRlcyBvZiBBbWVyaWNhLiYjeEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgU2VjdGlvbiBvZiBE
aWFiZXRlcyBhbmQgTWV0YWJvbGlzbSwgSGFyYm9yLVVDTEEgTWVkaWNhbCBDZW50ZXIsIFRvcnJh
bmNlLCBDYWxpZm9ybmlhLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4RDtEaXZpc2lvbiBv
ZiBLaWRuZXksIFVyb2xvZ2ljLCBhbmQgSGVtYXRvbG9naWMgRGlzZWFzZXMsIE5hdGlvbmFsIElu
c3RpdHV0ZSBvZiBEaWFiZXRlcyBhbmQgRGlnZXN0aXZlIGFuZCBLaWRuZXkgRGlzZWFzZXMsIEJl
dGhlc2RhLCBNYXJ5bGFuZCwgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7Sm9obnMgSG9w
a2lucyBCbG9vbWJlcmcgU2Nob29sIG9mIFB1YmxpYyBIZWFsdGgsIEpvaG5zIEhvcGtpbnMgU2No
b29sIG9mIE1lZGljaW5lLCBCYWx0aW1vcmUsIE1hcnlsYW5kLCBVbml0ZWQgU3RhdGVzIG9mIEFt
ZXJpY2EuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIENoaWNhZ28g
TWVkaWNpbmUsIENoaWNhZ28sIElsbGlub2lzLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4
RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBMb3lvbGEgU2Nob29sIG9mIE1lZGljaW5lLCBNYXl3
b29kLCBJbGxpbm9pcywgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7RGVwYXJ0bWVudCBv
ZiBFcGlkZW1pb2xvZ3ksIEpvaG5zIEhvcGtpbnMgQmxvb21iZXJnIFNjaG9vbCBvZiBQdWJsaWMg
SGVhbHRoLCBCYWx0aW1vcmUsIE1hcnlsYW5kLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4
RDtIZWlkZWxiZXJnIFVuaXZlcnNpdHkgYW5kIFN5bmxhYiBBY2FkZW15LCBVbml2ZXJzaXR5IG9m
IEdyYXosIEdyYXosIEF1c3RyaWEuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBVbml2ZXJz
aXR5IG9mIENhbGlmb3JuaWEsIExvcyBBbmdlbGVzLCBMb3MgQW5nZWxlcywgQ2FsaWZvcm5pYSwg
VW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7VGhlb2Rvc2l1cyBEb2J6aGFuc2t5IENlbnRl
ciBmb3IgR2Vub21lIEJpb2luZm9ybWF0aWNzLCBTdC4gUGV0ZXJzYnVyZywgUnVzc2lhLCBhbmQg
T2NlYW5vZ3JhcGhpYyBDZW50ZXIsIE5vdmEgU291dGhlYXN0ZXJuIFVuaXZlcnNpdHksIEZ0LiBM
YXVkZXJkYWxlLCBGbG9yaWRhLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4RDtEZXBhcnRt
ZW50IG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIENhbGlmb3JuaWEsIElydmluZSwgSXJ2aW5l
LCBDYWxpZm9ybmlhLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4RDtEZXBhcnRtZW50cyBv
ZiBQYWVkaWF0cmljcyBhbmQgTWVkaWNpbmUsIEhvc3BpdGFsIGZvciBTaWNrIENoaWxkcmVuLCBV
bml2ZXJzaXR5IEhlYWx0aCBOZXR3b3JrIGFuZCB0aGUgVW5pdmVyc2l0eSBvZiBUb3JvbnRvLCBU
b3JvbnRvLCBPbnRhcmlvLCBDYW5hZGEuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBKb3Ns
aW4gRGlhYmV0ZXMgQ2VudGVyLCBIYXJ2YXJkIE1lZGljYWwgU2Nob29sLCBCb3N0b24sIE1hc3Nh
Y2h1c2V0dHMsIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYS4mI3hEO05hdGlvbmFsIEluc3RpdHV0
ZSBvZiBEaWFiZXRlcyBhbmQgRGlnZXN0aXZlIERpc2Vhc2UsIE5hdGlvbmFsIEluc3RpdHV0ZXMg
b2YgSGVhbHRoLCBCZXRoZXNkYSwgTWFyeWxhbmQsIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYS4m
I3hEO0NlbnRlciBmb3IgUmVzZWFyY2ggb24gR2Vub21pY3MgYW5kIEdsb2JhbCBIZWFsdGgsIEJl
dGhlc2RhLCBNYXJ5bGFuZCwgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7RGVwYXJ0bWVu
dHMgb2YgTWVkaWNpbmUsIENhc2UgV2VzdGVybiBSZXNlcnZlIFVuaXZlcnNpdHksIENsZXZlbGFu
ZCwgT2hpbywgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7RGVwYXJ0bWVudCBvZiBCaW9j
aGVtaXN0cnkgYW5kIE1vbGVjdWxhciBNZWRpY2luZSwgVUMgRGF2aXMgU2Nob29sIG9mIE1lZGlj
aW5lLCBEYXZpcywgQ2FsaWZvcm5pYSwgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYjeEQ7RGVw
YXJ0bWVudCBvZiBCaW9jaGVtaXN0cnkgJmFtcDsgTW9sZWN1bGFyIEJpb2xvZ3ksIFVuaXZlcnNp
dHkgb2YgTmV3IE1leGljbywgQWxidXF1ZXJxdWUsIE5ldyBNZXhpY28sIFVuaXRlZCBTdGF0ZXMg
b2YgQW1lcmljYS4mI3hEO0pvc2xpbiBEaWFiZXRlcyBDZW50ZXIsIFNlY3Rpb24gb24gR2VuZXRp
Y3MgYW5kIEVwaWRlbWlvbG9neSwgQm9zdG9uLCBNYXNzYWNodXNldHRzLCBVbml0ZWQgU3RhdGVz
IG9mIEFtZXJpY2EuJiN4RDtOYXRpb25hbCBIdW1hbiBHZW5vbWUgUmVzZWFyY2ggSW5zdGl0dXRl
LCBSb2NrdmlsbGUsIE1hcnlsYW5kLCBVbml0ZWQgU3RhdGVzIG9mIEFtZXJpY2EuJiN4RDtEZXBh
cnRtZW50IG9mIE1lZGljaW5lLCBUaGUgVW5pdmVyc2l0eSBvZiBUZXhhcyBIZWFsdGggU2NpZW5j
ZSBDZW50ZXIsIFNhbiBBbnRvbmlvLCBUZXhhcywgVW5pdGVkIFN0YXRlcyBvZiBBbWVyaWNhLiYj
eEQ7TmVwaHJvbG9neSwgVW5pdmVyc2l0eSBvZiBBbGFiYW1hIEJpcm1pbmdoYW0sIEJpcm1pbmdo
YW0sIEFsYWJhbWEsIFVuaXRlZCBTdGF0ZXMgb2YgQW1lcmljYS4mI3hEO0RlcGFydG1lbnQgb2Yg
TWVkaWNpbmUsIERpdmlzaW9uIG9mIE5lcGhyb2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWwgV3Vy
emJ1cmcsIFd1cnpidXJnLCBHZXJtYW55LiYjeEQ7Q2VudGVyIGZvciBDYW5jZXIgUmVzZWFyY2gs
IE5hdGlvbmFsIENhbmNlciBJbnN0aXR1dGUsIEZyZWRlcmljaywgTWFyeWxhbmQsIFVuaXRlZCBT
dGF0ZXMgb2YgQW1lcmljYS4mI3hEO0RlcGFydG1lbnQgb2YgSW50ZXJuYWwgTWVkaWNpbmUsIFVu
aXZlcnNpdHkgb2YgTmV3IE1leGljbywgQWxidXF1ZXJxdWUsIE5ldyBNZXhpY28sIFVuaXRlZCBT
dGF0ZXMgb2YgQW1lcmljYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5vbWUtV2lk
ZSBBc3NvY2lhdGlvbiBhbmQgVHJhbnMtZXRobmljIE1ldGEtQW5hbHlzaXMgZm9yIEFkdmFuY2Vk
IERpYWJldGljIEtpZG5leSBEaXNlYXNlOiBGYW1pbHkgSW52ZXN0aWdhdGlvbiBvZiBOZXBocm9w
YXRoeSBhbmQgRGlhYmV0ZXMgKEZJTkQpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBMb1MgR2Vu
ZXQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlBMb1MgZ2VuZXRpY3M8L2FsdC10aXRsZT48
L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QTG9TIEdlbmV0PC9mdWxsLXRpdGxlPjwv
cGVyaW9kaWNhbD48cGFnZXM+ZTEwMDUzNTI8L3BhZ2VzPjx2b2x1bWU+MTE8L3ZvbHVtZT48bnVt
YmVyPjg8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWZyaWNhbiBBbWVyaWNhbnMvZ2VuZXRp
Y3M8L2tleXdvcmQ+PGtleXdvcmQ+RGlhYmV0ZXMgTWVsbGl0dXMsIFR5cGUgMi9jb21wbGljYXRp
b25zLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5EaWFiZXRpYyBOZXBocm9wYXRoaWVzL2V0
aG5vbG9neS8qZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+RXVyb3BlYW4gQ29udGluZW50YWwg
QW5jZXN0cnkgR3JvdXAvZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+R2VuZXRpYyBQcmVkaXNw
b3NpdGlvbiB0byBEaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkdlbm9tZS1XaWRlIEFzc29jaWF0
aW9uIFN0dWR5PC9rZXl3b3JkPjxrZXl3b3JkPkhpc3BhbmljIEFtZXJpY2Fucy9nZW5ldGljczwv
a2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5kaWFucywgTm9ydGgg
QW1lcmljYW4vZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+Uk5BLUJpbmRpbmcgUHJvdGVpbnMv
Z2VuZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlczwva2V5d29yZD48L2tleXdv
cmRzPjxkYXRlcz48eWVhcj4yMDE1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnPC9kYXRlPjwv
cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1My03NDA0IChFbGVjdHJvbmljKSYjeEQ7MTU1My03
MzkwIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNjMwNTg5NzwvYWNjZXNzaW9uLW51
bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+PHN0eWxlIGZhY2U9InVuZGVybGluZSIgZm9udD0i
ZGVmYXVsdCIgc2l6ZT0iMTAwJSI+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y
NjMwNTg5Nzwvc3R5bGU+PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjQ1NDkz
MDk8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEzNzEvam91cm5hbC5wZ2Vu
LjEwMDUzNTI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5v
dGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JeWVuZ2FyPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA 8; and UMOD rs77924615, originally associated with eGFR in both individuals with and without diabetes (P=5.2×10-4 for “CKD”)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb3Jza2k8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb3Jza2k8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 31. Associations at the AFF3, RGMA-MCTP2, and ERBB4 loci, identified in the GEnetics of Nephropathy—an International Effort (GENIE) consortiumPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kaG9sbTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kaG9sbTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+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ADDIN EN.CITE.DATA 12, comprised of a subset of studies included in this current effort, remained associated with DKD, though the associations were attenuated in this larger dataset (RGMA-MCTP2 rs12437854 P=2.97×10-5; AFF3 rs7583877 P=5.97×10-4; ERBB4 rs7588550 P=3.53×10-5; Figure S8). Associations were also observed at the CDCA7/SP3 (rs4972593, P=0.020 for “CKD-DN”, originally for ESRD exclusively in women ADDIN EN.CITE <EndNote><Cite><Author>Sandholm</Author><Year>2013</Year><RecNum>410</RecNum><DisplayText><style face="superscript">11</style></DisplayText><record><rec-number>410</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1381116555">410</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sandholm, Niina</author><author>McKnight, Amy Jayne</author><author>Salem, Rany M.</author><author>Brennan, Eoin P.</author><author>Forsblom, Carol</author><author>Harjutsalo, Valma</author><author>M?kinen, Ville-Petteri</author><author>McKay, Gareth J.</author><author>Sadlier, Denise M.</author><author>Williams, Winfred W.</author><author>Martin, Finian</author><author>Panduru, Nicolae Mircea</author><author>Tarnow, Lise</author><author>Tuomilehto, Jaakko</author><author>Tryggvason, Karl</author><author>Zerbini, Gianpaolo</author><author>Comeau, Mary E.</author><author>Langefeld, Carl D.</author><author>for the FIND Consortium</author><author>Godson, Catherine</author><author>Hirschhorn, Joel N.</author><author>Maxwell, Alexander P.</author><author>Florez, Jose C.</author><author>Groop, Per-Henrik</author></authors></contributors><titles><title>Chromosome 2q31.1 Associates with ESRD in Women with Type 1 Diabetes</title><secondary-title>Journal of the American Society of Nephrology</secondary-title></titles><periodical><full-title>Journal of the American Society of Nephrology</full-title></periodical><pages>1537-1543</pages><volume>24</volume><number>10</number><dates><year>2013</year><pub-dates><date>October 1, 2013</date></pub-dates></dates><urls><related-urls><url>) and GLRA3 (rs1564939, P=0.016 for “CKD extremes”, originally for AERPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kaG9sbTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYW5kaG9sbTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA 10,39), but these analyses also include individuals that overlap with the original studies. Apart from the UMOD locus, none of the 63 loci associated with eGFR in the general populationPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb3Jza2k8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb3Jza2k8L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 31 were associated with DKD after correction for multiple testing (P<7.0×10-4, Figure S9).Gene and gene set analysisWe conducted gene-level analyses by employing two methods that aggregate SNP summary statistics over a gene region while accounting for linkage disequilibrium, MAGMA and PASCALPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1wYXJ0ZXI8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1wYXJ0ZXI8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy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ADDIN EN.CITE.DATA 40,41. MAGMA identified five genes at a Bonferroni-corrected threshold (P<0.05/18,222 genes tested = 2.74×10-6): the collagen gene COL20A1 associated with “CKD extreme” (full model P=5.77×10-7) and “ESRD vs. non-ESRD” (full model P=9.53×10-7), SLC46A2 associated with “All vs. ctrl” (P=7.38×10-7), SFXN4 associated with “Macro” (full model P=1.65×10-7), GLT6D1 associated with “ESRD vs. macro” (P=1.49×10-6), and SNX30 associated with “All vs ctrl” (P=2.49×10-6) (Table S8). Although PASCAL did not identify any significant gene level associations, the five MAGMA-identified genes had P<5.0×10-4 in PASCAL (Table S9). Both SFXN4 and CBX8 have been reported to be differentially methylated in patients with diabetes with and without nephropathyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWxsPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZWxsPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 42,43. Additionally, we used MAGMA, PASCAL, DEPICT, and MAGENTA to conduct gene-set analysis in our GWAS dataset. The four methods identified 12 significantly enriched gene sets (Table S10). One gene set, “negative regulators of RIG-I MDA5 signaling” was identified in two different pathway analyses (MAGMA and PASCAL) of our fully adjusted GWAS of ESRD vs. Macro. Several additional related and overlapping gene sets were identified, including “RIGI MDA5 mediated induction of IFN alpha beta pathways”, “TRAF3 dependent IRF activation pathway”, and “TRAF6 mediated IRF activation” (PASCAL) and “activated TLR4 signaling” (MAGENTA). RIG-I, MDA5 and the toll-like receptor TLR4 are members of the innate immune response system that respond to both cellular injury and infectionPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb288L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb288L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA 44,45 and transduce highly intertwined signaling cascades. These include the signaling molecules TRAF3 and TRAF6, which induce expression of type I interferons and proinflammatory cytokines implicated in the progression of DKDPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JhPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JhPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 46,47. Specifically, the TLR4 receptor and several of its ligands and downstream cytokines display differential levels of expression in DKD renal tubules vs. normal kidneys and vs. non-diabetic kidney disease controlsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA 48, and TLR4 knockout mice are protected from DKD and display marked reductions in interstitial collagen deposition in the kidneyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051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 EN.CITE.DATA 49. Other pathways of interest include “other lipid, fatty acid and steroid metabolism”, “nitric oxide signaling in the cardiovascular system”, and “Tumor necrosis factor (TNF) family member”, with both nitric oxide and TNF-? implicated in DKD ADDIN EN.CITE <EndNote><Cite><Author>Colhoun</Author><Year>2018</Year><RecNum>79</RecNum><DisplayText><style face="superscript">50</style></DisplayText><record><rec-number>79</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542682808">79</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Colhoun, H. M.</author><author>Marcovecchio, M. L.</author></authors></contributors><auth-address>MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. Helen.colhoun@igmm.ed.ac.uk.
Department of Paediatrics, University of Cambridge, Cambridge, UK.</auth-address><titles><title>Biomarkers of diabetic kidney disease</title><secondary-title>Diabetologia</secondary-title></titles><periodical><full-title>Diabetologia</full-title></periodical><pages>996-1011</pages><volume>61</volume><number>5</number><edition>2018/03/10</edition><keywords><keyword>*Biomarker</keyword><keyword>*Diabetic kidney disease</keyword><keyword>*Epidemiology</keyword><keyword>*Nephropathy</keyword><keyword>*Review</keyword></keywords><dates><year>2018</year><pub-dates><date>May</date></pub-dates></dates><isbn>1432-0428 (Electronic)
0012-186X (Linking)</isbn><accession-num>29520581</accession-num><urls><related-urls><url>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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0tuaWdodDwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+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ADDIN EN.CITE.DATA 51,52.Expression and epigenetic analysesWe interrogated gene expression datasets in relevant tissues to determine whether our top signals underlie expression quantitative trait loci (eQTL). We first analyzed genotype and RNAseq gene expression data from 96 whole human kidney cortical samplesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LbzwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA 22 and micro-dissected human kidney samples (121 tubule and 119 glomerular samples)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA 23 from subjects of European descent without any evidence of renal disease (Figure S10). No findings in this data set achieved significance after correction for multiple testing. In the GTEx and eQTLgen datasets, COL4A3 rs55703767 had a significant eQTL (P=5.63×10-38) with the MFF gene in blood, but is most likely due to modest LD with other nearby strong eQTLs in the region. rs118124843 near DDR1 and VARS2 had multiple significant eQTLs in blood besides VARS2 (P=1.71×10-5; Table S11). Interestingly, rs142823282 near TAMM41 was a cis-eQTL for PPARG (P=4.60×10-7), a transcription factor regulating adipocyte development, glucose and lipid metabolism; PPARγ agonists have been suggested to prevent DKDPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFzbWFuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaGFzbWFuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE.DATA 53. To ascertain the potential functional role of our top non-coding signals, we mined ChIP-seq data derived from healthy adult human kidney samples ADDIN EN.CITE <EndNote><Cite><Author>Bernstein</Author><Year>2010</Year><RecNum>525</RecNum><DisplayText><style face="superscript">25</style></DisplayText><record><rec-number>525</rec-number><foreign-keys><key app="EN" db-id="dzr5svr2kwt2d5ez9epx9px6xs5059v9zxav" timestamp="1560792968">525</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bernstein, B. E.</author><author>Stamatoyannopoulos, J. A.</author><author>Costello, J. F.</author><author>Ren, B.</author><author>Milosavljevic, A.</author><author>Meissner, A.</author><author>Kellis, M.</author><author>Marra, M. A.</author><author>Beaudet, A. L.</author><author>Ecker, J. R.</author><author>Farnham, P. J.</author><author>Hirst, M.</author><author>Lander, E. S.</author><author>Mikkelsen, T. S.</author><author>Thomson, J. A.</author></authors></contributors><auth-address>Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Bernstein.Bradley@mgh.harvard.edu</auth-address><titles><title>The NIH Roadmap Epigenomics Mapping Consortium</title><secondary-title>Nat Biotechnol</secondary-title></titles><periodical><full-title>Nat Biotechnol</full-title></periodical><pages>1045-8</pages><volume>28</volume><number>10</number><edition>2010/10/15</edition><keywords><keyword>*Cooperative Behavior</keyword><keyword>*Epigenomics</keyword><keyword>Genome, Human/genetics</keyword><keyword>Humans</keyword><keyword>*National Institutes of Health (U.S.)</keyword><keyword>Reference Standards</keyword><keyword>Stem Cells/metabolism</keyword><keyword>United States</keyword></keywords><dates><year>2010</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1546-1696 (Electronic)
1087-0156 (Linking)</isbn><accession-num>20944595</accession-num><urls><related-urls><url>. SNP rs142823282 near TAMM41 was located close to kidney histone marks H3K27ac, H3K9ac, H3K4me1, and H3K4me3, suggesting that this is an active regulator of TAMM41 or another nearby gene (Figure S11). Interestingly, in recent work we have shown that DNA methylation profiles in participants with T1D with/without kidney disease show the greatest differences in methylation sites near TAMM41 ADDIN EN.CITE <EndNote><Cite><Author>Swan</Author><Year>2015</Year><RecNum>46</RecNum><DisplayText><style face="superscript">54</style></DisplayText><record><rec-number>46</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542680748">46</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Swan, E. J.</author><author>Maxwell, A. P.</author><author>McKnight, A. J.</author></authors></contributors><auth-address>Centre for Public Health, Queen's University of Belfast.
Regional Nephrology Unit, Belfast City Hospital, Belfast, UK.</auth-address><titles><title>Distinct methylation patterns in genes that affect mitochondrial function are associated with kidney disease in blood-derived DNA from individuals with Type 1 diabetes</title><secondary-title>Diabet Med</secondary-title></titles><periodical><full-title>Diabet Med</full-title></periodical><pages>1110-5</pages><volume>32</volume><number>8</number><edition>2015/04/09</edition><keywords><keyword>Case-Control Studies</keyword><keyword>DNA Methylation</keyword><keyword>DNA, Mitochondrial/*metabolism</keyword><keyword>Diabetes Mellitus, Type 1/*complications</keyword><keyword>Diabetic Nephropathies/etiology/*genetics</keyword><keyword>Epigenesis, Genetic</keyword><keyword>Genes, Mitochondrial</keyword><keyword>Humans</keyword><keyword>Kidney Failure, Chronic/etiology/*genetics</keyword><keyword>Mitochondria/*genetics/metabolism</keyword><keyword>Renal Insufficiency, Chronic/etiology/genetics</keyword></keywords><dates><year>2015</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1464-5491 (Electronic)
0742-3071 (Linking)</isbn><accession-num>25850930</accession-num><urls><related-urls><url>. To establish whether the expression of our top genes shows enrichment in a specific kidney cell type, we queried an expression dataset of ~50,000 single cells obtained from mouse kidneysPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj
TnVtPjQ3PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+MjQ8
L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj40NzwvcmVjLW51bWJlcj48
Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IndhcHYwYTl0cWFycHd6ZTV6MHQ1OWY1
aHowdHJ3MjV6ZnAyYSIgdGltZXN0YW1wPSIxNTQyNjgwNzk3Ij40Nzwva2V5PjwvZm9yZWlnbi1r
ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp
YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+UGFyaywgSi48L2F1dGhvcj48YXV0aG9yPlNocmVzdGhh
LCBSLjwvYXV0aG9yPjxhdXRob3I+UWl1LCBDLjwvYXV0aG9yPjxhdXRob3I+S29uZG8sIEEuPC9h
dXRob3I+PGF1dGhvcj5IdWFuZywgUy48L2F1dGhvcj48YXV0aG9yPldlcnRoLCBNLjwvYXV0aG9y
PjxhdXRob3I+TGksIE0uPC9hdXRob3I+PGF1dGhvcj5CYXJhc2NoLCBKLjwvYXV0aG9yPjxhdXRo
b3I+U3VzenRhaywgSy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk
cmVzcz5SZW5hbCBFbGVjdHJvbHl0ZSBhbmQgSHlwZXJ0ZW5zaW9uIERpdmlzaW9uLCBEZXBhcnRt
ZW50IG9mIE1lZGljaW5lIGFuZCBHZW5ldGljcywgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEs
IFBoaWxhZGVscGhpYSwgUEEgMTkxMDQsIFVTQS4mI3hEO1JlbmFsIERpdmlzaW9uLCBEZXBhcnRt
ZW50IG9mIE1lZGljaW5lLCBDb2x1bWJpYSBVbml2ZXJzaXR5LCBOZXcgWW9yaywgTlkgMTAwMzIs
IFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgQmlvc3RhdGlzdGljcywgRXBpZGVtaW9sb2d5IGFuZCBJ
bmZvcm1hdGljcywgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxhZGVscGhpYSwgUEEg
MTkxMDQsIFVTQS4mI3hEO1JlbmFsIEVsZWN0cm9seXRlIGFuZCBIeXBlcnRlbnNpb24gRGl2aXNp
b24sIERlcGFydG1lbnQgb2YgTWVkaWNpbmUgYW5kIEdlbmV0aWNzLCBVbml2ZXJzaXR5IG9mIFBl
bm5zeWx2YW5pYSwgUGhpbGFkZWxwaGlhLCBQQSAxOTEwNCwgVVNBLiBrc3VzenRha0BwZW5ubWVk
aWNpbmUudXBlbm4uZWR1LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlNpbmdsZS1jZWxs
IHRyYW5zY3JpcHRvbWljcyBvZiB0aGUgbW91c2Uga2lkbmV5IHJldmVhbHMgcG90ZW50aWFsIGNl
bGx1bGFyIHRhcmdldHMgb2Yga2lkbmV5IGRpc2Vhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+
U2NpZW5jZTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PlNjaWVuY2U8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz43NTgtNzYzPC9wYWdlcz48
dm9sdW1lPjM2MDwvdm9sdW1lPjxudW1iZXI+NjM5MDwvbnVtYmVyPjxlZGl0aW9uPjIwMTgvMDQv
MDc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+
Q2VsbCBQbGFzdGljaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkNlbGwgVHJhY2tpbmcvKm1ldGhvZHM8
L2tleXdvcmQ+PGtleXdvcmQ+R2VuZSBFeHByZXNzaW9uIFByb2ZpbGluZy8qbWV0aG9kczwva2V5
d29yZD48a2V5d29yZD5HZW5ldGljIE1hcmtlcnM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r
ZXl3b3JkPjxrZXl3b3JkPktpZG5leSBEaXNlYXNlcy8qZ2VuZXRpY3M8L2tleXdvcmQ+PGtleXdv
cmQ+S2lkbmV5IFR1YnVsZXMsIENvbGxlY3RpbmcvKmN5dG9sb2d5LyptZXRhYm9saXNtPC9rZXl3
b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdvcmQ+PGtleXdvcmQ+UmVjZXB0b3JzLCBOb3RjaC9tZXRh
Ym9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEFuYWx5c2lzLCBSTkEvbWV0aG9kczwv
a2V5d29yZD48a2V5d29yZD5TaWduYWwgVHJhbnNkdWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlNp
bmdsZS1DZWxsIEFuYWx5c2lzLyptZXRob2RzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5
ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXkgMTg8L2RhdGU+PC9wdWItZGF0ZXM+
PC9kYXRlcz48aXNibj4xMDk1LTkyMDMgKEVsZWN0cm9uaWMpJiN4RDswMDM2LTgwNzUgKExpbmtp
bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI5NjIyNzI0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxy
ZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yOTYy
MjcyNDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2MTg4NjQ1PC9jdXN0
b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTI2L3NjaWVuY2UuYWFyMjEzMTwvZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj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 EN.CITE.DATA 24. Expression was detected for six genes in the mouse kidney atlas: three (COL4A3, SNCAIP, and BMP7) were almost exclusively expressed in podocytes (Figure 5), supporting the significant role for podocytes in DKD. Gene expression levels in kidneys in cases vs. controls were predicted with TWAS based on the GWAS summary statistics and eQTL data of kidney glomeruli and tubuli.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5RaXU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxSZWNO
dW0+NTE4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+MjM8
L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj41MTg8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJkenI1c3ZyMmt3dDJkNWV6OWVweDlw
eDZ4czUwNTl2OXp4YXYiIHRpbWVzdGFtcD0iMTU1OTMyNzc1MCI+NTE4PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5RaXUsIEMuPC9hdXRob3I+PGF1dGhvcj5IdWFuZywg
Uy48L2F1dGhvcj48YXV0aG9yPlBhcmssIEouPC9hdXRob3I+PGF1dGhvcj5QYXJrLCBZLjwvYXV0
aG9yPjxhdXRob3I+S28sIFkuIEEuPC9hdXRob3I+PGF1dGhvcj5TZWFzb2NrLCBNLiBKLjwvYXV0
aG9yPjxhdXRob3I+QnJ5ZXIsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5YdSwgWC4gWC48L2F1dGhv
cj48YXV0aG9yPlNvbmcsIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5QYWxtZXIsIE0uPC9hdXRob3I+
PGF1dGhvcj5IaWxsLCBKLjwvYXV0aG9yPjxhdXRob3I+R3Vhcm5pZXJpLCBQLjwvYXV0aG9yPjxh
dXRob3I+SGF3a2lucywgSi48L2F1dGhvcj48YXV0aG9yPkJvdXN0YW55LUthcmksIEMuIE0uPC9h
dXRob3I+PGF1dGhvcj5QdWxsZW4sIFMuIFMuPC9hdXRob3I+PGF1dGhvcj5Ccm93biwgQy4gRC48
L2F1dGhvcj48YXV0aG9yPlN1c3p0YWssIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0
b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgUmVuYWwgRWxlY3Ryb2x5
dGUgYW5kIEh5cGVydGVuc2lvbiBEaXZpc2lvbiwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEs
IFBoaWxhZGVscGhpYSwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgR2VuZXRpY3MsIFVuaXZl
cnNpdHkgb2YgUGVubnN5bHZhbmlhLCBQZXJlbG1hbiBTY2hvb2wgb2YgTWVkaWNpbmUsIFBoaWxh
ZGVscGhpYSwgUEEsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgQ2VsbCBCaW9sb2d5LCBTeWx2ZXN0
ZXIgQ29tcHJlaGVuc2l2ZSBDYW5jZXIgQ2VudGVyLCBVbml2ZXJzaXR5IG9mIE1pYW1pIE1pbGxl
ciBTY2hvb2wgb2YgTWVkaWNpbmUsIE1pYW1pLCBGTCwgVVNBLiYjeEQ7RGVwYXJ0bWVudCBvZiBT
eXN0ZW1zIFBoYXJtYWNvbG9neSBhbmQgVHJhbnNsYXRpb25hbCBUaGVyYXBldXRpY3MsIFBlcmVs
bWFuIFNjaG9vbCBvZiBNZWRpY2luZSBhdCBVbml2ZXJzaXR5IG9mIFBlbm5zeWx2YW5pYSwgUGVu
bnN5bHZhbmlhLCBQQSwgVVNBLiYjeEQ7UGF0aG9sb2d5IGFuZCBMYWJvcmF0b3J5IE1lZGljaW5l
IGF0IHRoZSBIb3NwaXRhbCBvZiB0aGUgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxh
ZGVscGhpYSwgUEEsIFVTQS4mI3hEO0JvZWhyaW5nZXIgSW5nZWxoZWltIFBoYXJtYWNldXRpY2Fs
cywgSW5jLiwgUmlkZ2VmaWVsZCwgQ1QsIFVTQS4mI3hEO0RlcGFydG1lbnQgb2YgTWVkaWNpbmUs
IFJlbmFsIEVsZWN0cm9seXRlIGFuZCBIeXBlcnRlbnNpb24gRGl2aXNpb24sIFVuaXZlcnNpdHkg
b2YgUGVubnN5bHZhbmlhLCBQaGlsYWRlbHBoaWEsIFBBLCBVU0EuIGtzdXN6dGFrQHBlbm5tZWRp
Y2luZS51cGVubi5lZHUuJiN4RDtEZXBhcnRtZW50IG9mIEdlbmV0aWNzLCBVbml2ZXJzaXR5IG9m
IFBlbm5zeWx2YW5pYSwgUGVyZWxtYW4gU2Nob29sIG9mIE1lZGljaW5lLCBQaGlsYWRlbHBoaWEs
IFBBLCBVU0EuIGtzdXN6dGFrQHBlbm5tZWRpY2luZS51cGVubi5lZHUuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+UmVuYWwgY29tcGFydG1lbnQtc3BlY2lmaWMgZ2VuZXRpYyB2YXJpYXRp
b24gYW5hbHlzZXMgaWRlbnRpZnkgbmV3IHBhdGh3YXlzIGluIGNocm9uaWMga2lkbmV5IGRpc2Vh
c2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+TmF0IE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5hdCBNZWQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp
Y2FsPjxwYWdlcz4xNzIxLTE3MzE8L3BhZ2VzPjx2b2x1bWU+MjQ8L3ZvbHVtZT48bnVtYmVyPjEx
PC9udW1iZXI+PGVkaXRpb24+MjAxOC8xMC8wMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+
QWRhcHRvciBQcm90ZWlucywgU2lnbmFsIFRyYW5zZHVjaW5nLypnZW5ldGljczwva2V5d29yZD48
a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkNlbGwgQ29tcGFydG1lbnRhdGlvbi9n
ZW5ldGljczwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVscywgQW5pbWFsPC9rZXl3b3Jk
PjxrZXl3b3JkPkdlbmUgRXhwcmVzc2lvbiBSZWd1bGF0aW9uL2dlbmV0aWNzPC9rZXl3b3JkPjxr
ZXl3b3JkPipHZW5ldGljIFByZWRpc3Bvc2l0aW9uIHRvIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdv
cmQ+R2Vub21lLVdpZGUgQXNzb2NpYXRpb24gU3R1ZHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z
PC9rZXl3b3JkPjxrZXl3b3JkPktpZG5leS9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgR2xvbWVydWx1cy9tZXRhYm9saXNtL3BhdGhvbG9neTwva2V5d29yZD48
a2V5d29yZD5LaWRuZXkgVHVidWxlcywgUHJveGltYWwvbWV0YWJvbGlzbS9wYXRob2xvZ3k8L2tl
eXdvcmQ+PGtleXdvcmQ+TWljZTwva2V5d29yZD48a2V5d29yZD5Qb2x5bW9ycGhpc20sIFNpbmds
ZSBOdWNsZW90aWRlL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YW50aXRhdGl2ZSBUcmFp
dCBMb2NpLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5SZW5hbCBJbnN1ZmZpY2llbmN5LCBD
aHJvbmljLypnZW5ldGljcy9waHlzaW9wYXRob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2lnbmFs
IFRyYW5zZHVjdGlvbi9nZW5ldGljczwva2V5d29yZD48a2V5d29yZD5UcmFuc2Zvcm1pbmcgR3Jv
d3RoIEZhY3RvciBiZXRhL2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPlR1bW9yIFN1cHByZXNz
b3IgUHJvdGVpbnMvKmdlbmV0aWNzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw
MTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
aXNibj4xNTQ2LTE3MFggKEVsZWN0cm9uaWMpJiN4RDsxMDc4LTg5NTYgKExpbmtpbmcpPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjMwMjc1NTY2PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDI3NTU2NjwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM2MzAxMDExPC9jdXN0b20yPjxlbGVj
dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L3M0MTU5MS0wMTgtMDE5NC00PC9lbGVjdHJvbmlj
LXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA 23 While none of the genes survived correction for multiple testing, analysis suggested 18 genes with differential expression in cases and controls with P<1×10-4, including the NPNT, PRRC2C, and VPS33B genes (Table S12). NPNT encodes for nephronectin, an extra-cellular matrix protein on GBM. Knocking out NPNT or decreasing NPNT expression levels have been shown to induce podocyte injury related to GBM.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdWxsZXItRGVpbGU8L0F1dGhvcj48WWVhcj4yMDE3PC9Z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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdWxsZXItRGVpbGU8L0F1dGhvcj48WWVhcj4yMDE3PC9Z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ADDIN EN.CITE.DATA 55 On the contrary, TWAS predicted higher NPNT expression within DN cases vs. normal AER. In line with our TWAS finding, NPNT is significantly upregulated in glomeruli of diabetic nephropathy mouse model vs. non-diabetic mouse (p=6.4x10-4, fold change 1.3, in top 2%, accessed through ).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2RnaW48L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2RnaW48L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA 56 Furthermore, a variant near PRRC2C was recently associated with albuminuria in the UK Biobank,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aYW5ldHRpPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aYW5ldHRpPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48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ADDIN EN.CITE.DATA 57 and rare mutations in VPS33B gene cause arthrogryposis, renal dysfunction, and cholestasis-1 (ARCS1) syndrome involving proximal–tubular dysfunction and usually death by the age of 1.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib2xtZTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA 58DISCUSSIONOur genome-wide analysis of 19,406 participants with T1D identified 16 genome-wide significant loci associated with DKD, four of which remained significant after a conservative correction for multiple testing. Four of the 16 genome-wide significant signals are in or near genes with known or suggestive biology related to renal function/collagen (COL4A3, BMP7, COLEC11, and DDR1), but this is the first time that naturally occurring variation (MAF > 1%) in these loci has been associated with DKD. Our most significant signal was a protective missense variant in COL4A3, rs55703767, reaching both genome-wide and study-wide significance with multiple definitions of DKD. Moreover, this variant demonstrated a significant association with GBM width such that protective allele carriers had thinner GBM before any signs of kidney disease, and its effect was dependent on glycemia. COL4A3, with COL4A4 and COL4A5, make up the so-called “novel chains” of type IV collagen ADDIN EN.CITE <EndNote><Cite><Author>Kleppel</Author><Year>1992</Year><RecNum>48</RecNum><DisplayText><style face="superscript">59</style></DisplayText><record><rec-number>48</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542680859">48</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kleppel, M. M.</author><author>Fan, W.</author><author>Cheong, H. I.</author><author>Michael, A. F.</author></authors></contributors><auth-address>Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455.</auth-address><titles><title>Evidence for separate networks of classical and novel basement membrane collagen. Characterization of alpha 3(IV)-alport antigen heterodimer</title><secondary-title>J Biol Chem</secondary-title></titles><periodical><full-title>J Biol Chem</full-title></periodical><pages>4137-42</pages><volume>267</volume><number>6</number><edition>1992/02/25</edition><keywords><keyword>Animals</keyword><keyword>Basement Membrane/*chemistry</keyword><keyword>Blotting, Western</keyword><keyword>Cattle</keyword><keyword>Collagen/*chemistry</keyword><keyword>Descemet Membrane/chemistry</keyword><keyword>Electrophoresis, Gel, Two-Dimensional</keyword><keyword>Humans</keyword><keyword>Kidney Glomerulus/chemistry</keyword><keyword>Lens, Crystalline/chemistry</keyword><keyword>Nephritis, Hereditary/*immunology</keyword><keyword>Precipitin Tests</keyword></keywords><dates><year>1992</year><pub-dates><date>Feb 25</date></pub-dates></dates><isbn>0021-9258 (Print)
0021-9258 (Linking)</isbn><accession-num>1740456</accession-num><urls><related-urls><url>, which together play both structural and signaling roles in the GBM. Specifically, COL4A3 is known to bind a number of molecules including integrins, heparin and heparin sulfate proteoglycans, and other components of the GBM such as laminin and nidogen. These interactions mediate the contact between cells and the underlying collagen IV basement membrane, and regulate various processes essential to embryonic development and normal physiology including cell adhesion, proliferation, survival and differentiation. Dysregulation of these interactions has been implicated in several pathological conditions including CKD ADDIN EN.CITE <EndNote><Cite><Author>Khoshnoodi</Author><Year>2008</Year><RecNum>49</RecNum><DisplayText><style face="superscript">60</style></DisplayText><record><rec-number>49</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542680931">49</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Khoshnoodi, J.</author><author>Pedchenko, V.</author><author>Hudson, B. G.</author></authors></contributors><auth-address>Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA. jamshid.khoshnoodi@vanderbilt.edu</auth-address><titles><title>Mammalian collagen IV</title><secondary-title>Microsc Res Tech</secondary-title></titles><periodical><full-title>Microsc Res Tech</full-title></periodical><pages>357-70</pages><volume>71</volume><number>5</number><edition>2008/01/26</edition><keywords><keyword>Animals</keyword><keyword>Anti-Glomerular Basement Membrane Disease/genetics/metabolism</keyword><keyword>Chromosomes, Human</keyword><keyword>Collagen Type IV/*chemistry/genetics/*metabolism</keyword><keyword>Gene Expression Regulation, Developmental</keyword><keyword>Genetic Diseases, Inborn/genetics/metabolism</keyword><keyword>Humans</keyword><keyword>Integrins/metabolism</keyword><keyword>Mammals/embryology/genetics/*metabolism</keyword><keyword>Multigene Family</keyword><keyword>Nephritis, Hereditary/genetics/metabolism</keyword><keyword>Protein Conformation</keyword><keyword>Protein Processing, Post-Translational</keyword></keywords><dates><year>2008</year><pub-dates><date>May</date></pub-dates></dates><isbn>1059-910X (Print)
1059-910X (Linking)</isbn><accession-num>18219669</accession-num><urls><related-urls><url>. Mutations in COL4A3 are responsible for the autosomal recessive form of Alport syndrome, a progressive inherited nephropathy, as well as benign familial hematuria, characterized by thin (or variable width) GBM, and thought to be a milder form of Alport syndromePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXNodGFuPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LYXNodGFuPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48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ADDIN EN.CITE.DATA 61. Furthermore, mutations in COL4A3 have also been identified in patients with focal segmental glomerulosclerosis (FSGS), often leading to proteinuria and renal failure. Some of these patients with FSGS presented with segmental GBM thinning.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5YaWU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5YaWU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA 62 Of note, the common rs55703767 (COL4A3 Asp326Tyr) variant, protecting from DKD, was also associated with thinner GBM in individuals with diabetes but without renal complications, a feature that seems to be beneficial in the context of diabetes. The rs55703767 SNP is predicted to alter the third amino acid of the canonical triple-helical domain sequence of Glycine (G)-X-Y (where X and Y are often proline (P) and hydroxyproline (Y), respectively) from G-E-D (D=Aspartic) to G-E-YPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJraW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJraW48L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA 63, potentially impacting the structure of the collagen complex. In addition, a recent studyPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFuPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HdWFuPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 64 of candidate genes involved in renal structure reported rs34505188 in COL4A3 (not in linkage disequilibrium with rs55703767, r2=0.0006) to be associated with ESRD in African Americans with T2D (MAF=2%, OR=1.55, P=5×10-4). Together with the trend towards association we have seen in SUMMIT and the glycemic interaction we have reported here, these findings suggest variation in COL4A3 may be associated with DKD in T2D as well.Given its association as a protective SNP, we can speculate that the rs55703767 variant may confer tensile strength or flexibility to the GBM, which may be of particular relevance in the glomerular hypertension associated with DKD. Alternatively, COL4A3 may regulate the rates of production and/or turnover of other GBM components, affecting GBM width changes in diabetes. How these effects might confer protection in a manner dependent on ambient glucose concentrations is unknown. Future mechanistic studies will be required to determine the precise role of this variant in DKD; elucidation of its interaction with glycemia in providing protection might be relevant to other molecules implicated in diabetic complications.In keeping with the collagen pathway, the synonymous exonic variant rs118124843, which reached genome-wide significance for the “Micro” phenotype, is located near DDR1, the gene encoding the discoidin domain-containing receptor 1. Based on chromatin conformation interaction data from Capture HiC Plotter (CHiCP), ADDIN EN.CITE <EndNote><Cite><Author>Schofield</Author><Year>2016</Year><RecNum>93</RecNum><DisplayText><style face="superscript">65</style></DisplayText><record><rec-number>93</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1544468653">93</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schofield, E. C.</author><author>Carver, T.</author><author>Achuthan, P.</author><author>Freire-Pritchett, P.</author><author>Spivakov, M.</author><author>Todd, J. A.</author><author>Burren, O. S.</author></authors></contributors><auth-address>JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.</auth-address><titles><title>CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets</title><secondary-title>Bioinformatics</secondary-title></titles><periodical><full-title>Bioinformatics</full-title></periodical><pages>2511-3</pages><volume>32</volume><number>16</number><edition>2016/05/07</edition><keywords><keyword>Chromosomes</keyword><keyword>Computer Graphics</keyword><keyword>Genome</keyword><keyword>Genomics</keyword><keyword>*Internet</keyword><keyword>*Promoter Regions, Genetic</keyword><keyword>*Regulatory Elements, Transcriptional</keyword><keyword>*Software</keyword></keywords><dates><year>2016</year><pub-dates><date>Aug 15</date></pub-dates></dates><isbn>1367-4811 (Electronic)
1367-4803 (Linking)</isbn><accession-num>27153610</accession-num><urls><related-urls><url> the rs118124843 containing fragment interacts with six gene promoter regions, including DDR1, suggesting that the variant regulates DDR1 expression across multiple tissues (Table S11). DDR1 is a collagen receptor ADDIN EN.CITE <EndNote><Cite><Author>Alves</Author><Year>1995</Year><RecNum>66</RecNum><DisplayText><style face="superscript">66</style></DisplayText><record><rec-number>66</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542681971">66</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Alves, F.</author><author>Vogel, W.</author><author>Mossie, K.</author><author>Millauer, B.</author><author>Hofler, H.</author><author>Ullrich, A.</author></authors></contributors><auth-address>Department of Molecular Biology, Max-Planck-Institute fur Biochemie, Martinsried, Germany.</auth-address><titles><title>Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer</title><secondary-title>Oncogene</secondary-title></titles><periodical><full-title>Oncogene</full-title></periodical><pages>609-18</pages><volume>10</volume><number>3</number><edition>1995/02/02</edition><keywords><keyword>Amino Acid Sequence</keyword><keyword>Discoidins</keyword><keyword>Fungal Proteins/*chemistry</keyword><keyword>Humans</keyword><keyword>*Lectins</keyword><keyword>Molecular Sequence Data</keyword><keyword>Neoplasms/*enzymology</keyword><keyword>Polymerase Chain Reaction</keyword><keyword>*Protozoan Proteins</keyword><keyword>Receptor Protein-Tyrosine Kinases/biosynthesis/*chemistry</keyword><keyword>Tumor Cells, Cultured</keyword></keywords><dates><year>1995</year><pub-dates><date>Feb 2</date></pub-dates></dates><isbn>0950-9232 (Print)
0950-9232 (Linking)</isbn><accession-num>7845687</accession-num><urls><related-urls><url> shown to bind type IV collagenPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Wb2dlbDwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Wb2dlbDwvQXV0aG9yPjxZZWFyPjE5OTc8L1llYXI+PFJl
Y051bT42ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQiPjY3
PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+Njg8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3YXB2MGE5dHFhcnB3emU1ejB0NTlm
NWh6MHRydzI1emZwMmEiIHRpbWVzdGFtcD0iMTU0MjY4MjA5MiI+Njg8L2tleT48L2ZvcmVpZ24t
a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy
aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlZvZ2VsLCBXLjwvYXV0aG9yPjxhdXRob3I+R2lzaCwg
Ry4gRC48L2F1dGhvcj48YXV0aG9yPkFsdmVzLCBGLjwvYXV0aG9yPjxhdXRob3I+UGF3c29uLCBU
LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlByb2dyYW1t
ZSBpbiBNb2xlY3VsYXIgQmlvbG9neSBhbmQgQ2FuY2VyLCBTYW11ZWwgTHVuZW5mZWxkIFJlc2Vh
cmNoIEluc3RpdHV0ZSwgTW91bnQgU2luYWkgSG9zcGl0YWwsIFRvcm9udG8sIE9udGFyaW8sIENh
bmFkYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgZGlzY29pZGluIGRvbWFpbiBy
ZWNlcHRvciB0eXJvc2luZSBraW5hc2VzIGFyZSBhY3RpdmF0ZWQgYnkgY29sbGFnZW48L3RpdGxl
PjxzZWNvbmRhcnktdGl0bGU+TW9sIENlbGw8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVy
aW9kaWNhbD48ZnVsbC10aXRsZT5Nb2wgQ2VsbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBh
Z2VzPjEzLTIzPC9wYWdlcz48dm9sdW1lPjE8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRp
dGlvbj4xOTk4LzA3LzExPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BbWlubyBBY2lkIFNl
cXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+QmluZGlu
ZyBTaXRlcy9kcnVnIGVmZmVjdHMvcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5CaW9jb21w
YXRpYmxlIE1hdGVyaWFsczwva2V5d29yZD48a2V5d29yZD5CcmVhc3QgTmVvcGxhc21zPC9rZXl3
b3JkPjxrZXl3b3JkPkNhcmJvaHlkcmF0ZSBNZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNh
cmJvaHlkcmF0ZXMvY2hlbWlzdHJ5PC9rZXl3b3JkPjxrZXl3b3JkPkNvbGxhZ2VuLyptZXRhYm9s
aXNtL3BoYXJtYWNvbG9neTwva2V5d29yZD48a2V5d29yZD5Db2xsYWdlbmFzZXMvYmlvc3ludGhl
c2lzL3BoYXJtYWNvbG9neTwva2V5d29yZD48a2V5d29yZD5EaXNjb2lkaW4gRG9tYWluIFJlY2Vw
dG9yczwva2V5d29yZD48a2V5d29yZD5EcnVnIENvbWJpbmF0aW9uczwva2V5d29yZD48a2V5d29y
ZD5FeHRyYWNlbGx1bGFyIE1hdHJpeCBQcm90ZWlucy9tZXRhYm9saXNtL3BoYXJtYWNvbG9neTwv
a2V5d29yZD48a2V5d29yZD5GaWJyb2JsYXN0cy9jaGVtaXN0cnkvY3l0b2xvZ3kvZW56eW1vbG9n
eTwva2V5d29yZD48a2V5d29yZD5GaWJyb3NhcmNvbWE8L2tleXdvcmQ+PGtleXdvcmQ+SG90IFRl
bXBlcmF0dXJlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5LaWRu
ZXkvY3l0b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+
TGFtaW5pbjwva2V5d29yZD48a2V5d29yZD5MaWdhbmRzPC9rZXl3b3JkPjxrZXl3b3JkPk1hdHJp
eCBNZXRhbGxvcHJvdGVpbmFzZSAxPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdvcmQ+PGtl
eXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVwc2luIEEv
cGhhcm1hY29sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlBob3NwaG9yeWxhdGlvbjwva2V5d29yZD48
a2V5d29yZD5Qcm90ZWluIERlbmF0dXJhdGlvbjwva2V5d29yZD48a2V5d29yZD5Qcm90ZWluIFN0
cnVjdHVyZSwgVGVydGlhcnk8L2tleXdvcmQ+PGtleXdvcmQ+UHJvdGVvZ2x5Y2Fuczwva2V5d29y
ZD48a2V5d29yZD5SZWNlcHRvciBQcm90ZWluLVR5cm9zaW5lIEtpbmFzZXMvY2hlbWlzdHJ5L21l
dGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+UmVjZXB0b3JzLCBNaXRvZ2VuLypjaGVtaXN0cnkv
Km1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+VGVuZG9ucy9jaGVtaXN0cnk8L2tleXdvcmQ+
PGtleXdvcmQ+VHVtb3IgQ2VsbHMsIEN1bHR1cmVkL2NoZW1pc3RyeS9kcnVnIGVmZmVjdHMvZW56
eW1vbG9neTwva2V5d29yZD48a2V5d29yZD5UeXJvc2luZS9tZXRhYm9saXNtPC9rZXl3b3JkPjwv
a2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2Rh
dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk3LTI3NjUgKFByaW50KSYjeEQ7MTA5Ny0y
NzY1IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT45NjU5ODk5PC9hY2Nlc3Npb24tbnVt
Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1
Ym1lZC85NjU5ODk5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48
L0VuZE5vdGU+AG==
ADDIN EN.CITE.DATA 67, and is highly expressed in kidneys, particularly upon renal injury ADDIN EN.CITE <EndNote><Cite><Author>Dorison</Author><Year>2018</Year><RecNum>67</RecNum><DisplayText><style face="superscript">68</style></DisplayText><record><rec-number>67</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542682023">67</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dorison, A.</author><author>Chantziantoniou, C.</author></authors></contributors><auth-address>a Inserm UMR S 1155 and Sorbonne Universite , Paris , France.</auth-address><titles><title>DDR1: A major player in renal diseases</title><secondary-title>Cell Adh Migr</secondary-title></titles><periodical><full-title>Cell Adh Migr</full-title></periodical><pages>299-304</pages><volume>12</volume><number>4</number><edition>2018/02/20</edition><keywords><keyword>Chronic Kidney Disease</keyword><keyword>Fibrotic lesions</keyword><keyword>Pro-inflammatory processes</keyword><keyword>Therapeutic target</keyword><keyword>Tyrosine kinase receptor</keyword></keywords><dates><year>2018</year></dates><isbn>1933-6926 (Electronic)
1933-6918 (Linking)</isbn><accession-num>29455614</accession-num><urls><related-urls><url>. Upon renal injury, Ddr1-deficient mice display lower levels of collagenPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA 69, decreased proteinuria, and an increased survival rate compared to wild-type controlsPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZXJyb2NoPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZXJyb2NoPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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==
ADDIN EN.CITE.DATA 70, with Ddr1/Col4a3 double knockout mice displaying protection from progressive renal fibrosis and prolonged lifespan compared to Col4a3 knockout mice alonePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA 69. Thus, through its role in collagen binding DDR1 has been suggested as a possible therapeutic target for kidney diseasePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9zczwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA 69. The association of rs12615970, an intronic variant on chromosome 2 near the COLEC11 gene, met genome-wide significance for the CKD phenotype, as well as nominal significance for multiple albuminuria-based traits. The rs12615970 containing fragment was found to interact with COLEC11, ALLC, and ADI1 transcription start sites in chromatin conformation data on GM12878 cell line (Table S11)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hvZmllbGQ8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hvZmllbGQ8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFy
PjxSZWNOdW0+OTM8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0
Ij42NSw3MTwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjkzPC9yZWMt
bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0id2FwdjBhOXRxYXJwd3pl
NXowdDU5ZjVoejB0cncyNXpmcDJhIiB0aW1lc3RhbXA9IjE1NDQ0Njg2NTMiPjkzPC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TY2hvZmllbGQsIEUuIEMuPC9hdXRob3I+
PGF1dGhvcj5DYXJ2ZXIsIFQuPC9hdXRob3I+PGF1dGhvcj5BY2h1dGhhbiwgUC48L2F1dGhvcj48
YXV0aG9yPkZyZWlyZS1Qcml0Y2hldHQsIFAuPC9hdXRob3I+PGF1dGhvcj5TcGl2YWtvdiwgTS48
L2F1dGhvcj48YXV0aG9yPlRvZGQsIEouIEEuPC9hdXRob3I+PGF1dGhvcj5CdXJyZW4sIE8uIFMu
PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+SkRSRi9XZWxs
Y29tZSBUcnVzdCBEaWFiZXRlcyBhbmQgSW5mbGFtbWF0aW9uIExhYm9yYXRvcnksIE5JSFIgQ2Ft
YnJpZGdlIEJpb21lZGljYWwgUmVzZWFyY2ggQ2VudHJlLCBEZXBhcnRtZW50IG9mIE1lZGljYWwg
R2VuZXRpY3MsIENhbWJyaWRnZSBJbnN0aXR1dGUgZm9yIE1lZGljYWwgUmVzZWFyY2gsIFVuaXZl
cnNpdHkgb2YgQ2FtYnJpZGdlLCBDYW1icmlkZ2UgQ0IyIDBYWSwgVUsuJiN4RDtOdWNsZWFyIER5
bmFtaWNzIFByb2dyYW1tZSwgVGhlIEJhYnJhaGFtIEluc3RpdHV0ZSwgQ2FtYnJpZGdlIENCMjIg
M0FULCBVSy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5DSGlDUDogYSB3ZWItYmFzZWQg
dG9vbCBmb3IgdGhlIGludGVncmF0aXZlIGFuZCBpbnRlcmFjdGl2ZSB2aXN1YWxpemF0aW9uIG9m
IHByb21vdGVyIGNhcHR1cmUgSGktQyBkYXRhc2V0czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5C
aW9pbmZvcm1hdGljczwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs
LXRpdGxlPkJpb2luZm9ybWF0aWNzPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MjUx
MS0zPC9wYWdlcz48dm9sdW1lPjMyPC92b2x1bWU+PG51bWJlcj4xNjwvbnVtYmVyPjxlZGl0aW9u
PjIwMTYvMDUvMDc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNocm9tb3NvbWVzPC9rZXl3
b3JkPjxrZXl3b3JkPkNvbXB1dGVyIEdyYXBoaWNzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbm9tZTwv
a2V5d29yZD48a2V5d29yZD5HZW5vbWljczwva2V5d29yZD48a2V5d29yZD4qSW50ZXJuZXQ8L2tl
eXdvcmQ+PGtleXdvcmQ+KlByb21vdGVyIFJlZ2lvbnMsIEdlbmV0aWM8L2tleXdvcmQ+PGtleXdv
cmQ+KlJlZ3VsYXRvcnkgRWxlbWVudHMsIFRyYW5zY3JpcHRpb25hbDwva2V5d29yZD48a2V5d29y
ZD4qU29mdHdhcmU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48
cHViLWRhdGVzPjxkYXRlPkF1ZyAxNTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEz
NjctNDgxMSAoRWxlY3Ryb25pYykmI3hEOzEzNjctNDgwMyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz
c2lvbi1udW0+MjcxNTM2MTA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs
Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI3MTUzNjEwPC91cmw+PC9yZWxh
dGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzQ5Nzg5MjY8L2N1c3RvbTI+PGVsZWN0cm9uaWMt
cmVzb3VyY2UtbnVtPjEwLjEwOTMvYmlvaW5mb3JtYXRpY3MvYnR3MTczPC9lbGVjdHJvbmljLXJl
c291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NaWZzdWQ8L0F1dGhvcj48
WWVhcj4yMDE1PC9ZZWFyPjxSZWNOdW0+OTQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjk0
PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0id2FwdjBhOXRx
YXJwd3plNXowdDU5ZjVoejB0cncyNXpmcDJhIiB0aW1lc3RhbXA9IjE1NDQ0Njg3NjkiPjk0PC9r
ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl
Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NaWZzdWQsIEIuPC9hdXRob3I+
PGF1dGhvcj5UYXZhcmVzLUNhZGV0ZSwgRi48L2F1dGhvcj48YXV0aG9yPllvdW5nLCBBLiBOLjwv
YXV0aG9yPjxhdXRob3I+U3VnYXIsIFIuPC9hdXRob3I+PGF1dGhvcj5TY2hvZW5mZWxkZXIsIFMu
PC9hdXRob3I+PGF1dGhvcj5GZXJyZWlyYSwgTC48L2F1dGhvcj48YXV0aG9yPldpbmdldHQsIFMu
IFcuPC9hdXRob3I+PGF1dGhvcj5BbmRyZXdzLCBTLjwvYXV0aG9yPjxhdXRob3I+R3JleSwgVy48
L2F1dGhvcj48YXV0aG9yPkV3ZWxzLCBQLiBBLjwvYXV0aG9yPjxhdXRob3I+SGVybWFuLCBCLjwv
YXV0aG9yPjxhdXRob3I+SGFwcGUsIFMuPC9hdXRob3I+PGF1dGhvcj5IaWdncywgQS48L2F1dGhv
cj48YXV0aG9yPkxlUHJvdXN0LCBFLjwvYXV0aG9yPjxhdXRob3I+Rm9sbG93cywgRy4gQS48L2F1
dGhvcj48YXV0aG9yPkZyYXNlciwgUC48L2F1dGhvcj48YXV0aG9yPkx1c2NvbWJlLCBOLiBNLjwv
YXV0aG9yPjxhdXRob3I+T3Nib3JuZSwgQy4gUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz4xXSBUaGUgRnJhbmNpcyBDcmljayBJbnN0aXR1dGUsIExvbmRv
biwgVUsuIFsyXSBVQ0wgR2VuZXRpY3MgSW5zdGl0dXRlLCBVbml2ZXJzaXR5IENvbGxlZ2UgTG9u
ZG9uLCBMb25kb24sIFVLLiYjeEQ7VGhlIEZyYW5jaXMgQ3JpY2sgSW5zdGl0dXRlLCBMb25kb24s
IFVLLiYjeEQ7TnVjbGVhciBEeW5hbWljcyBQcm9ncmFtbWUsIEJhYnJhaGFtIEluc3RpdHV0ZSwg
Q2FtYnJpZGdlLCBVSy4mI3hEO0Jpb2luZm9ybWF0aWNzIEdyb3VwLCBCYWJyYWhhbSBJbnN0aXR1
dGUsIENhbWJyaWRnZSwgVUsuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljYWwgYW5kIE1vbGVjdWxh
ciBHZW5ldGljcywgS2luZyZhcG9zO3MgQ29sbGVnZSBMb25kb24gU2Nob29sIG9mIE1lZGljaW5l
LCBMb25kb24sIFVLLiYjeEQ7RGlhZ25vc3RpY3MgYW5kIEdlbm9taWNzIERpdmlzaW9uLCBBZ2ls
ZW50IFRlY2hub2xvZ2llcywgU2FudGEgQ2xhcmEsIENhbGlmb3JuaWEsIFVTQS4mI3hEO0RlcGFy
dG1lbnQgb2YgSGFlbWF0b2xvZ3ksIENhbWJyaWRnZSBVbml2ZXJzaXR5IEhvc3BpdGFscyBOYXRp
b25hbCBIZWFsdGggU2VydmljZSAoTkhTKSBGb3VuZGF0aW9uIFRydXN0LCBDYW1icmlkZ2UsIFVL
LiYjeEQ7MV0gVGhlIEZyYW5jaXMgQ3JpY2sgSW5zdGl0dXRlLCBMb25kb24sIFVLLiBbMl0gVUNM
IEdlbmV0aWNzIEluc3RpdHV0ZSwgVW5pdmVyc2l0eSBDb2xsZWdlIExvbmRvbiwgTG9uZG9uLCBV
Sy4gWzNdIE9raW5hd2EgSW5zdGl0dXRlIG9mIFNjaWVuY2UgYW5kIFRlY2hub2xvZ3ksIE9raW5h
d2EsIEphcGFuLiYjeEQ7MV0gTnVjbGVhciBEeW5hbWljcyBQcm9ncmFtbWUsIEJhYnJhaGFtIElu
c3RpdHV0ZSwgQ2FtYnJpZGdlLCBVSy4gWzJdIERlcGFydG1lbnQgb2YgTWVkaWNhbCBhbmQgTW9s
ZWN1bGFyIEdlbmV0aWNzLCBLaW5nJmFwb3M7cyBDb2xsZWdlIExvbmRvbiBTY2hvb2wgb2YgTWVk
aWNpbmUsIExvbmRvbiwgVUsuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TWFwcGluZyBs
b25nLXJhbmdlIHByb21vdGVyIGNvbnRhY3RzIGluIGh1bWFuIGNlbGxzIHdpdGggaGlnaC1yZXNv
bHV0aW9uIGNhcHR1cmUgSGktQzwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OYXQgR2VuZXQ8L3Nl
Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OYXQgR2VuZXQ8
L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz41OTgtNjA2PC9wYWdlcz48dm9sdW1lPjQ3
PC92b2x1bWU+PG51bWJlcj42PC9udW1iZXI+PGVkaXRpb24+MjAxNS8wNS8wNjwvZWRpdGlvbj48
a2V5d29yZHM+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxrZXl3b3JkPkNocm9tb3NvbWUg
TWFwcGluZzwva2V5d29yZD48a2V5d29yZD5FcGlzdGFzaXMsIEdlbmV0aWM8L2tleXdvcmQ+PGtl
eXdvcmQ+R2VuZSBFeHByZXNzaW9uIFJlZ3VsYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+R2VuZSBS
ZWd1bGF0b3J5IE5ldHdvcmtzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbm9tZSwgSHVtYW48L2tleXdv
cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHltb3JwaGlzbSwgU2luZ2xl
IE51Y2xlb3RpZGU8L2tleXdvcmQ+PGtleXdvcmQ+KlByb21vdGVyIFJlZ2lvbnMsIEdlbmV0aWM8
L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48cHViLWRhdGVzPjxk
YXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1NDYtMTcxOCAoRWxlY3Ry
b25pYykmI3hEOzEwNjEtNDAzNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjU5Mzg5
NDM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5j
YmkubmxtLm5paC5nb3YvcHVibWVkLzI1OTM4OTQzPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz
PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDM4L25nLjMyODY8L2VsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA 65,71. Collectin-11 is an innate immune factor synthesized by multiple cell types, including renal epithelial cells with a role in pattern recognition and host defense against invasive pathogens, through binding to fructose and mannose sugar moietiesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWxtYW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
ZWNOdW0+NjI8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij43
Miw3Mzwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjYyPC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0id2FwdjBhOXRxYXJwd3plNXow
dDU5ZjVoejB0cncyNXpmcDJhIiB0aW1lc3RhbXA9IjE1NDI2ODE4MDEiPjYyPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TZWxtYW4sIEwuPC9hdXRob3I+PGF1dGhvcj5I
YW5zZW4sIFMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+
RGVwYXJ0bWVudCBvZiBDYW5jZXIgJmFtcDsgSW5mbGFtbWF0aW9uIFJlc2VhcmNoLCBJbnN0aXR1
dGUgb2YgTW9sZWN1bGFyIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFNvdXRoZXJuIERlbm1hcmss
IERlbm1hcmsuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U3RydWN0dXJlIGFuZCBmdW5j
dGlvbiBvZiBjb2xsZWN0aW4gbGl2ZXIgMSAoQ0wtTDEpIGFuZCBjb2xsZWN0aW4gMTEgKENMLTEx
LCBDTC1LMSk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SW1tdW5vYmlvbG9neTwvc2Vjb25kYXJ5
LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkltbXVub2Jpb2xvZ3k8L2Z1
bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz44NTEtNjM8L3BhZ2VzPjx2b2x1bWU+MjE3PC92
b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGVkaXRpb24+MjAxMi8wNC8wNjwvZWRpdGlvbj48a2V5
d29yZHM+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5d29yZD5DYXJib2h5ZHJhdGVzPC9r
ZXl3b3JkPjxrZXl3b3JkPkNvbGxlY3RpbnMvKmNoZW1pc3RyeS9nZW5ldGljcy8qbWV0YWJvbGlz
bTwva2V5d29yZD48a2V5d29yZD5Db21wbGVtZW50IFN5c3RlbSBQcm90ZWlucy9tZXRhYm9saXNt
PC9rZXl3b3JkPjxrZXl3b3JkPkROQS9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkRpc2Vh
c2UgTW9kZWxzLCBBbmltYWw8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3
b3JkPk1hY3JvbW9sZWN1bGFyIFN1YnN0YW5jZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFubm9zZS1C
aW5kaW5nIFByb3RlaW4tQXNzb2NpYXRlZCBTZXJpbmUgUHJvdGVhc2VzL21ldGFib2xpc208L2tl
eXdvcmQ+PGtleXdvcmQ+UG9seXNhY2NoYXJpZGVzL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdv
cmQ+UHJvdGVpbiBCaW5kaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlN5bmRyb21lPC9rZXl3b3JkPjwv
a2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2Rh
dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc4LTMyNzkgKEVsZWN0cm9uaWMpJiN4RDsw
MTcxLTI5ODUgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyNDc1NDEwPC9hY2Nlc3Np
b24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWgu
Z292L3B1Ym1lZC8yMjQ3NTQxMDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmltYmlvLjIwMTEuMTIuMDA4PC9lbGVjdHJvbmljLXJl
c291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5IYW5zZW48L0F1dGhvcj48
WWVhcj4yMDEwPC9ZZWFyPjxSZWNOdW0+NjM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjYz
PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0id2FwdjBhOXRx
YXJwd3plNXowdDU5ZjVoejB0cncyNXpmcDJhIiB0aW1lc3RhbXA9IjE1NDI2ODE4MDEiPjYzPC9r
ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl
Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5IYW5zZW4sIFMuPC9hdXRob3I+
PGF1dGhvcj5TZWxtYW4sIEwuPC9hdXRob3I+PGF1dGhvcj5QYWxhbml5YXIsIE4uPC9hdXRob3I+
PGF1dGhvcj5aaWVnbGVyLCBLLjwvYXV0aG9yPjxhdXRob3I+QnJhbmR0LCBKLjwvYXV0aG9yPjxh
dXRob3I+S2xpZW0sIEEuPC9hdXRob3I+PGF1dGhvcj5Kb25hc3NvbiwgTS48L2F1dGhvcj48YXV0
aG9yPlNram9lZHQsIE0uIE8uPC9hdXRob3I+PGF1dGhvcj5OaWVsc2VuLCBPLjwvYXV0aG9yPjxh
dXRob3I+SGFydHNob3JuLCBLLjwvYXV0aG9yPjxhdXRob3I+Sm9yZ2Vuc2VuLCBULiBKLjwvYXV0
aG9yPjxhdXRob3I+U2tqb2R0LCBLLjwvYXV0aG9yPjxhdXRob3I+SG9sbXNrb3YsIFUuPC9hdXRo
b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBD
YW5jZXIgYW5kIEluZmxhbW1hdGlvbiBSZXNlYXJjaCwgVW5pdmVyc2l0eSBvZiBTb3V0aGVybiBE
ZW5tYXJrLCBPZGVuc2UsIERlbm1hcmsuIFNIYW5zZW5AaGVhbHRoLnNkdS5kazwvYXV0aC1hZGRy
ZXNzPjx0aXRsZXM+PHRpdGxlPkNvbGxlY3RpbiAxMSAoQ0wtMTEsIENMLUsxKSBpcyBhIE1BU1At
MS8zLWFzc29jaWF0ZWQgcGxhc21hIGNvbGxlY3RpbiB3aXRoIG1pY3JvYmlhbC1iaW5kaW5nIGFj
dGl2aXR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogSW1tdW5vbDwvc2Vjb25kYXJ5LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogSW1tdW5vbDwvZnVsbC10aXRsZT48
L3BlcmlvZGljYWw+PHBhZ2VzPjYwOTYtMTA0PC9wYWdlcz48dm9sdW1lPjE4NTwvdm9sdW1lPjxu
dW1iZXI+MTA8L251bWJlcj48ZWRpdGlvbj4yMDEwLzEwLzIwPC9lZGl0aW9uPjxrZXl3b3Jkcz48
a2V5d29yZD5BbWlubyBBY2lkIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tl
eXdvcmQ+PGtleXdvcmQ+QmFzZSBTZXF1ZW5jZTwva2V5d29yZD48a2V5d29yZD5CbG90dGluZywg
V2VzdGVybjwva2V5d29yZD48a2V5d29yZD5DaHJvbWF0b2dyYXBoeSwgR2VsPC9rZXl3b3JkPjxr
ZXl3b3JkPkNvbGxlY3RpbnMvKmdlbmV0aWNzLyppbW11bm9sb2d5LyptZXRhYm9saXNtPC9rZXl3
b3JkPjxrZXl3b3JkPkVuenltZS1MaW5rZWQgSW1tdW5vc29yYmVudCBBc3NheTwva2V5d29yZD48
a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkltbXVuaXR5LCBJbm5hdGU8L2tleXdv
cmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+TWFubm9z
ZS1CaW5kaW5nIFByb3RlaW4tQXNzb2NpYXRlZCBTZXJpbmUgUHJvdGVhc2VzPC9rZXl3b3JkPjxr
ZXl3b3JkPk1hc3MgU3BlY3Ryb21ldHJ5PC9rZXl3b3JkPjxrZXl3b3JkPk1vbGVjdWxhciBTZXF1
ZW5jZSBEYXRhPC9rZXl3b3JkPjxrZXl3b3JkPlJldmVyc2UgVHJhbnNjcmlwdGFzZSBQb2x5bWVy
YXNlIENoYWluIFJlYWN0aW9uPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8
L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3YgMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
aXNibj4xNTUwLTY2MDYgKEVsZWN0cm9uaWMpJiN4RDswMDIyLTE3NjcgKExpbmtpbmcpPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjIwOTU2MzQwPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMDk1NjM0MDwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuNDA0OS9q
aW1tdW5vbC4xMDAyMTg1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+
PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWxtYW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA 72,73. Mice with kidney-specific deficiency of COLEC11 are protected against ischemia-induced tubule injury due to reduced complement deposition ADDIN EN.CITE <EndNote><Cite><Author>Farrar</Author><Year>2016</Year><RecNum>64</RecNum><DisplayText><style face="superscript">74</style></DisplayText><record><rec-number>64</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542681853">64</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Farrar, C. A.</author><author>Tran, D.</author><author>Li, K.</author><author>Wu, W.</author><author>Peng, Q.</author><author>Schwaeble, W.</author><author>Zhou, W.</author><author>Sacks, S. H.</author></authors></contributors><titles><title>Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury</title><secondary-title>J Clin Invest</secondary-title></titles><periodical><full-title>J Clin Invest</full-title></periodical><pages>1911-25</pages><volume>126</volume><number>5</number><edition>2016/04/19</edition><keywords><keyword>Acute Kidney Injury/chemically induced/genetics/*metabolism/pathology</keyword><keyword>Animals</keyword><keyword>Collectins/genetics/*metabolism</keyword><keyword>Complement Pathway, Mannose-Binding Lectin/*drug effects/genetics</keyword><keyword>Complement System Proteins/genetics/*metabolism</keyword><keyword>Fucose/*toxicity</keyword><keyword>Kidney Tubules, Proximal/*injuries/*metabolism/pathology</keyword><keyword>Mannose-Binding Protein-Associated Serine Proteases/genetics/metabolism</keyword><keyword>Mice</keyword><keyword>Mice, Knockout</keyword></keywords><dates><year>2016</year><pub-dates><date>May 2</date></pub-dates></dates><isbn>1558-8238 (Electronic)
0021-9738 (Linking)</isbn><accession-num>27088797</accession-num><urls><related-urls><url>, and mutations in COLEC11 have been identified in families with 3MC syndrome, a series of rare autosomal recessive disorders resulting in birth defects and abnormal development, including kidney abnormalitiesPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb29yeWNrPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48
UmVjTnVtPjY1PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+
NzU8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj42NTwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IndhcHYwYTl0cWFycHd6ZTV6MHQ1
OWY1aHowdHJ3MjV6ZnAyYSIgdGltZXN0YW1wPSIxNTQyNjgxOTA3Ij42NTwva2V5PjwvZm9yZWln
bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u
dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Um9vcnljaywgQy48L2F1dGhvcj48YXV0aG9yPkRp
YXotRm9udCwgQS48L2F1dGhvcj48YXV0aG9yPk9zYm9ybiwgRC4gUC48L2F1dGhvcj48YXV0aG9y
PkNoYWJjaG91YiwgRS48L2F1dGhvcj48YXV0aG9yPkhlcm5hbmRlei1IZXJuYW5kZXosIFYuPC9h
dXRob3I+PGF1dGhvcj5TaGFtc2VsZGluLCBILjwvYXV0aG9yPjxhdXRob3I+S2VubnksIEouPC9h
dXRob3I+PGF1dGhvcj5XYXRlcnMsIEEuPC9hdXRob3I+PGF1dGhvcj5KZW5raW5zLCBELjwvYXV0
aG9yPjxhdXRob3I+S2Fpc3NpLCBBLiBBLjwvYXV0aG9yPjxhdXRob3I+TGVhbCwgRy4gRi48L2F1
dGhvcj48YXV0aG9yPkRhbGxhcGljY29sYSwgQi48L2F1dGhvcj48YXV0aG9yPkNhcm5ldmFsZSwg
Ri48L2F1dGhvcj48YXV0aG9yPkJpdG5lci1HbGluZHppY3osIE0uPC9hdXRob3I+PGF1dGhvcj5M
ZWVzLCBNLjwvYXV0aG9yPjxhdXRob3I+SGVubmVrYW0sIFIuPC9hdXRob3I+PGF1dGhvcj5TdGFu
aWVyLCBQLjwvYXV0aG9yPjxhdXRob3I+QnVybnMsIEEuIEouPC9hdXRob3I+PGF1dGhvcj5QZWV0
ZXJzLCBILjwvYXV0aG9yPjxhdXRob3I+QWxrdXJheWEsIEYuIFMuPC9hdXRob3I+PGF1dGhvcj5C
ZWFsZXMsIFAuIEwuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl
c3M+TW9sZWN1bGFyIE1lZGljaW5lIFVuaXQsIFVuaXZlcnNpdHkgQ29sbGVnZSBMb25kb24gSW5z
dGl0dXRlIG9mIENoaWxkIEhlYWx0aCwgTG9uZG9uLCBVSy48L2F1dGgtYWRkcmVzcz48dGl0bGVz
Pjx0aXRsZT5NdXRhdGlvbnMgaW4gbGVjdGluIGNvbXBsZW1lbnQgcGF0aHdheSBnZW5lcyBDT0xF
QzExIGFuZCBNQVNQMSBjYXVzZSAzTUMgc3luZHJvbWU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+
TmF0IEdlbmV0PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0
bGU+TmF0IEdlbmV0PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTk3LTIwMzwvcGFn
ZXM+PHZvbHVtZT40Mzwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTEvMDEv
MjU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFibm9ybWFsaXRpZXMsIE11bHRpcGxlLypn
ZW5ldGljczwva2V5d29yZD48a2V5d29yZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkNlbGwg
TW92ZW1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2xlZnQgTGlwL2dlbmV0aWNzPC9rZXl3b3JkPjxr
ZXl3b3JkPkNsZWZ0IFBhbGF0ZS9nZW5ldGljczwva2V5d29yZD48a2V5d29yZD5Db2xsZWN0aW5z
LypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5Db21wbGVtZW50IFBhdGh3YXksIE1hbm5vc2Ut
QmluZGluZyBMZWN0aW4vKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkNyYW5pb2ZhY2lhbCBB
Ym5vcm1hbGl0aWVzLypnZW5ldGljczwva2V5d29yZD48a2V5d29yZD5DcmFuaW9zeW5vc3Rvc2Vz
L2dlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPkVwaXN0YXNpcywgR2VuZXRpYzwva2V5d29yZD48
a2V5d29yZD5NYW5ub3NlLUJpbmRpbmcgUHJvdGVpbi1Bc3NvY2lhdGVkIFNlcmluZSBQcm90ZWFz
ZXMvKmdlbmV0aWNzPC9rZXl3b3JkPjxrZXl3b3JkPk11dGF0aW9uPC9rZXl3b3JkPjxrZXl3b3Jk
Pk5ldXJhbCBDcmVzdC9jeXRvbG9neTwva2V5d29yZD48a2V5d29yZD5TeW5kcm9tZTwva2V5d29y
ZD48a2V5d29yZD5aZWJyYWZpc2g8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAx
MTwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp
c2JuPjE1NDYtMTcxOCAoRWxlY3Ryb25pYykmI3hEOzEwNjEtNDAzNiAoTGlua2luZyk8L2lzYm4+
PGFjY2Vzc2lvbi1udW0+MjEyNTgzNDM8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJs
cz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIxMjU4MzQzPC91cmw+
PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzMwNDU2Mjg8L2N1c3RvbTI+PGVsZWN0
cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMzgvbmcuNzU3PC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb29yeWNrPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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ADDIN EN.CITE.DATA 75.The intronic variant rs144434404, associated at study-wide significance with the microalbuminuria phenotype, resides within the bone morphogenetic protein 7 (BMP7) gene. BMP7 encodes a secreted ligand of the transforming growth factor-beta superfamily of proteins. Developmental processes are regulated by the BMP family of glycosylated extracellular matrix molecules, via serine/threonine kinase receptors and canonical Smad pathway signaling. Coordinated regulation of both BMP and BMP-antagonist expression is essential for developing tissues, and changes in the levels of either BMP or BMP-antagonists can contribute to disease progression such as fibrosis and cancer ADDIN EN.CITE <EndNote><Cite><Author>Walsh</Author><Year>2010</Year><RecNum>53</RecNum><DisplayText><style face="superscript">76</style></DisplayText><record><rec-number>53</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542681216">53</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Walsh, D. W.</author><author>Godson, C.</author><author>Brazil, D. P.</author><author>Martin, F.</author></authors></contributors><auth-address>School of Medicine and Medical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. david.walsh@ucd.ie</auth-address><titles><title>Extracellular BMP-antagonist regulation in development and disease: tied up in knots</title><secondary-title>Trends Cell Biol</secondary-title></titles><periodical><full-title>Trends Cell Biol</full-title></periodical><pages>244-56</pages><volume>20</volume><number>5</number><edition>2010/03/02</edition><keywords><keyword>Animals</keyword><keyword>Bone Development</keyword><keyword>Bone Morphogenetic Proteins/*antagonists & inhibitors/chemistry/*metabolism</keyword><keyword>Carrier Proteins/chemistry/*metabolism</keyword><keyword>Humans</keyword><keyword>Models, Molecular</keyword><keyword>Neoplasms/metabolism/pathology</keyword><keyword>Protein Binding</keyword><keyword>Protein Structure, Tertiary</keyword><keyword>*Signal Transduction</keyword></keywords><dates><year>2010</year><pub-dates><date>May</date></pub-dates></dates><isbn>1879-3088 (Electronic)
0962-8924 (Linking)</isbn><accession-num>20188563</accession-num><urls><related-urls><url>. BMP7 is required for renal morphogenesis, and Bmp7 knockout mice die soon after birth due to reduced ureteric bud branchingPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aZWlzYmVyZzwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aZWlzYmVyZzwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+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ADDIN EN.CITE.DATA 77-79. Maintenance of Bmp7 expression in glomerular podocytes and proximal tubules of diabetic mice prevents podocyte loss and reduces overall diabetic renal injuryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 38. More recently, we have identified a mechanism through which BMP7 orchestrates renal protection through Akt inhibition and highlights Akt inhibitors as potential anti-fibrotic therapeutics ADDIN EN.CITE <EndNote><Cite><Author>Higgins</Author><Year>2017</Year><RecNum>57</RecNum><DisplayText><style face="superscript">80</style></DisplayText><record><rec-number>57</rec-number><foreign-keys><key app="EN" db-id="wapv0a9tqarpwze5z0t59f5hz0trw25zfp2a" timestamp="1542681456">57</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Higgins, D. F.</author><author>Ewart, L. M.</author><author>Masterson, E.</author><author>Tennant, S.</author><author>Grebnev, G.</author><author>Prunotto, M.</author><author>Pomposiello, S.</author><author>Conde-Knape, K.</author><author>Martin, F. M.</author><author>Godson, C.</author></authors></contributors><auth-address>UCD Diabetes Complications Research Centre, School of Medicine, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: debra.higgins@ucd.ie.
UCD Diabetes Complications Research Centre, School of Medicine, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
F. Hoffmann-La Roche, Dept of Metabolic and Vascular Disease, CH4070 Basel, Switzerland.</auth-address><titles><title>BMP7-induced-Pten inhibits Akt and prevents renal fibrosis</title><secondary-title>Biochim Biophys Acta Mol Basis Dis</secondary-title></titles><periodical><full-title>Biochim Biophys Acta Mol Basis Dis</full-title></periodical><pages>3095-3104</pages><volume>1863</volume><number>12</number><edition>2017/09/20</edition><keywords><keyword>*Akt</keyword><keyword>*Anti-fibrotic</keyword><keyword>*Fibrosis</keyword><keyword>*Hypoxia</keyword><keyword>*pten</keyword><keyword>*TGFbeta(1)</keyword></keywords><dates><year>2017</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0925-4439 (Print)
0925-4439 (Linking)</isbn><accession-num>28923783</accession-num><urls><related-urls><url>. It is also noteworthy that the BMP7 antagonist grem-1 is implicated in DKDPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb3hidXJnaDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb3hidXJnaDwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+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ADDIN EN.CITE.DATA 81-83 and gremlin has been implicated as a biomarker of kidney disease ADDIN EN.CITE <EndNote><Cite><Author>Afkarian</Author><Year>2014</Year><RecNum>5723</RecNum><DisplayText><style face="superscript">84</style></DisplayText><record><rec-number>5723</rec-number><foreign-keys><key app="EN" db-id="9axfrvwd4rteemetv9jvewpbdfd00w5pve00" timestamp="1543070669">5723</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Afkarian, M.</author><author>Hirsch, I. B.</author><author>Tuttle, K. R.</author><author>Greenbaum, C.</author><author>Himmelfarb, J.</author><author>de Boer, I. H.</author></authors></contributors><auth-address>Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.</auth-address><titles><title>Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease</title><secondary-title>Physiol Rep</secondary-title></titles><periodical><full-title>Physiol Rep</full-title></periodical><pages>e12010</pages><volume>2</volume><number>5</number><edition>2014/05/06</edition><keywords><keyword>BMP pathway</keyword><keyword>WNT pathway</keyword><keyword>diabetic kidney disease</keyword><keyword>pathophysiology</keyword><keyword>renin-angiotensin system</keyword></keywords><dates><year>2014</year></dates><isbn>2051-817X (Print)
2051-817X (Linking)</isbn><accession-num>24793984</accession-num><urls><related-urls><url>. Strengths of this analysis include the large sample size, triple that of the previous largest GWAS; the uniform genotyping and quality control procedures; standardized imputation for all studies (1,000 Genomes reference panel); the inclusion of exome array content; the exploration of multiple standardized phenotype definitions of DKD; and supportive data from various sources of human kidney samples. Several of the loci identified have known correlations with kidney biology, suggesting that these are likely true associations with DKD. However, we acknowledge a number of limitations. First, nine variants have low MAF and were driven by only two cohorts, indicating that further validation will be required to increase confidence in these associations. Second, seven variants were significantly associated with microalbuminuria only, a trait shown to be less heritable in previous studies. We included these loci to maximize comprehensiveness in reporting novel DKD associations. Replication in independent samples and functional confirmation is required to validate all of these loci. Even though the gene-level, gene set and pathway analyses had limited power, these analyses identified several additional potential DKD loci and pathways, some with relevance to kidney biology, that require further follow-up. Finally, while we included only controls with a minimum diabetes duration of 15 years, we cannot fully rule out that some of the controls would progress to DKD in the future, as the improvements in diabetes treatment in the last decades have postponed the onset of complications. We also excluded cases with short diabetes duration to avoid renal complications that might be due to other causes. These phenotypic definitions were meant to overcome the limitation that in clinical practice kidney biopsies are rarely taken from individuals with diabetes to verify the diagnosis. As for any late onset disease, these challenges in phenotypic definition may have reduced our power to detect additional associations. We note, however, that this relatively small degree of contamination would lead to loss of power and increased type II error rather than false positive findings; therefore, it does not undermine the robustness of the associations reported here.Diabetic complications are unquestionably driven by hyperglycemia and partially prevented by improved glycemic control in both T1D and T2D, but there has been doubt over what contribution, if any, inherited factors contribute to disease risk. In line with previous genetic studies, this study with a markedly expanded sample size identified several loci strongly associated with DKD risk. These findings suggest that larger studies, aided by novel analyses and including T2D, will continue to enhance our understanding of the complex pathogenesis of DKD, paving the way for molecularly targeted preventive or therapeutic interventions. AUTHOR CONTRIBUTIONSConceptualization, C.G., A.P.M., P-H.G., J.N.H, and J.C.F.; Formal Analysis, R.M.S., J.B.C., N.S., E.V., C-D.L., J-J.C., M.G.P., A.M.S., C.Q., V.N., J.P., A.L., R.M., H.K., R.K., B.E.K., A.J.C., A.D.P., W-M.C., N.R.v-Z., and S.O-G.; Investigation M.G.P., A.M.S., J.S. C-X.Q., V.N., J.K.H, A.J.M, J.K.S-B., D.M.M., A.P.M., A.D.P., C.F., E.A., T.A., M.L., C.M.B-K., H.M.K., S.M., D.T., B.G., S.B.B., C.N.A.P., L.S., B.P., R.W., V.R., V.P., E.P., L.R., R.V., N.M.P., L.C.G., M.I.M., H.F.G., A.M., H.F., K.B., P.R., T.C., G.Z., M.M., S.H., C.F., W-M.C., and S.O-G; Resources A.M.S., V.H., A.J.M, R.G.N., M.L.C., M.M, X.G., J.K.S-B., D.M.M., J.G., R.G.M., A.P.M., A.D.P., W-M.C., and S.O-G; Data Curation L.T.H., C-D. L., J-J.C., A.M.S., V.H., J.S., A.J.M., R.K., B.E.K., K.E.L., X.G., M.M., M.L.C., J.K.S-B., D.M.M., J.G., R.G.M., A.P.M., W-M.C., and S.O-G; Writing – Original Draft R.M.S., J.N.T., N.S., J.B.C., E.P.B., D.A., R.D., M.F.H., L.T.H., A.D.P., and C.G.; Writing – Review & Editing R.M.S., J.N.T., N.S., J.B.C., E.P.B., D.A., R.D., M.F.H., L.T.H., A.D.P., C.G., C.Q., J.P., J.S., M.M., M-L.C., I.H.dB., F.M., A.J.M., G.M., A.P.M., K.S., M.I.M., L.G., S.S.R., C.F., J.N.H., and J.C.F.; Visualization R.M.S, J.N.T., N.S., J.B.C., M.P.G., C.Q., C-D.L., J-J.C., J.P., J.S., R.K., B.E.K., K.E.L., A.J.M., G.M., A.P.M., and A.D.P.; Project Administration J.N.T.; Supervision A.D.P., A.K., P-H.G., C.G., A.P.M., H.M.C., S.S.R., M.K., K.S., J.N.H, and J.C.F.; Funding Acquisition A.D.P., A.K., J.C.F., and J.N.H. All authors approved the final version of the manuscript.ACKNOWLEDGEMENTSThis study was supported by a grant from the JDRF (17-2013-7) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants R01 DK081923 and R01 DK105154. R.M.S was supported in part by JDRF # 3-APF-2014-111-A-N, and National Heart, Lung and Blood Institute (NHLBI) R00 HL122515. J.N.T. was supported by NIDDK K12-DK094721. N.S. received funds from the European Foundation for the Study of Diabetes (EFSD) Young Investigator Research Award funds and Academy of Finland (299200). C.G., D.A., E.B., E.M., M.H. and R.D. are supported by SFI-HRB US Ireland Research Partnership SFI15/US/B3130. R.G.N. was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The FinnDiane study was funded by JDRF (17-2013-7), Folkh?lsan Research Foundation, the Wilhelm and Else Stockmann Foundation, the Liv och H?lsa Foundation, Helsinki University Central Hospital Research Funds (EVO), the Novo Nordisk Foundation, and Academy of Finland (275614). The EDC study was supported by NIDDK grant DK34818 and by the Rossi Memorial Fund. The WESDR study was funded by National Eye Institute EY016379. The Sweden study was supported by Family Erling-Persson (K. B.) and Stig and Gunborg Westman foundations (H.F.G.). AusDiane acknowledges Dr. Bernhard Baumgartner from Department of Medicine, Diakonissen-Wehrle Hospital, Salzburg, Austria. LatDiane acknowledges the following doctors and researchers: A.Bogdanova, D. Grikmane, I.Care, A.Fjodorova, R.Graudi?a, A.Valtere, D.Teterovska, I.Dzīvīte-Kri?āne, I.Kirilova, U.Lauga-Tūri?a, K.Geldnere, D.Seisuma, N.Fokina, S.?teina, L.Jaunozola, I.Balcere, U.Gaili?a, E.Menise,?S.Broka,?L.Akmene, N. Kap?a, J. Nagaiceva, A. Pētersons, A. Lejnieks, I. Konrāde, I. Salna, A. Dekante, A. Grāmatniece, A. Sali?a, A. Silda, V. Me?e?ko, V. Mihejeva, K. Kudrjavceva, I. Marksa, M. Cirse, D. Zeme, S. Kalva-Vaivode, J. Klovi??, L. Nikitina-Za?e, S. Skrebinska, Z. Dzērve, R. Mallons. LitDiane acknowledges Dr. Jurate Lasiene, Prof. Dzilda Velickiene, Dr. Vladimiras Petrenko and Nurses from the Department of Endocrinology, Hospital of Lithuanian University of Health Sciences. RomDiane acknowledges the following doctors and researchers: M. Anghel, DM Cheta, BA Cimpoca, D. Cimponeriu, CN Cozma, N. Dandu, D. Dobrin, I Duta, AM Frentescu, C. Ionescu-Tirgoviste, R. Ionica, R. Lichiardopol, AL Oprea, NM Panduru , A. Pop, G. Pop, R. Radescu, S. Radu, M. Robu, C. Serafinceanu, M. Stavarachi, O Tudose from the ”N.C Paulescu” National Institute for Diabetes Nutrition and Metabolic Diseases from Bucharest, and M. Bacu, D. Clenciu, C. Graunteanu, M. Ioana, E. Mota and M. Mota from Craiova Emergency County Hospital.SUMMIT Consortium acknowledgements: This work was supported by the following funders: IMI (SUMMIT 115006); Wellcome Trust 098381, 090532, 106310; NIH R01-MH101814; and JDRF 2-SRA-2014-276-Q-R. SDR: Thanks to Maria Sterner and Malin Neptin for GWAS genotyping in the Scannia Diabetes Registry. Grants: Swedish Research Council, ERC-Adv res grant 269045-GENE TARGET T2D, Academy of Finland grantas 263401 and 267882, Sigrid JUselius Foundation. FinnDiane: We thank M. Parkkonen, A. Sandelin, A-R. Salonen, T. Soppela and J. Tuomikangas for skillful laboratory assistance in the FinnDiane study. We also thank all the subjects who participated in the FinnDiane study and gratefully acknowledge all the physicians and nurses at each centre involved in the recruitment of participants (Table S12). The FinnDiane Study was supported by grants from the Folkh?lsan Research Foundation, the Wilhelm and Else Stockmann Foundation, the Liv och H?lsa Foundation, Helsinki University Central Hospital Research Funds (EVO), the Novo Nordisk Foundation, European Foundation for the Study of Diabetes (EFSD) Young Investigator Research Award funds, and the Academy of Finland (275614 and 299200). GoDARTS: We are grateful to all the participants in this study, the general practitioners, the Scottish School of Primary Care for their help in recruiting the participants, and to the whole team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. The study complies with the Declaration of Helsinki. We acknowledge the support of the Health Informatics Centre, University of Dundee for managing and supplying the anonymised data and NHS Tayside, the original data owner. The Wellcome Trust United Kingdom Type 2 Diabetes Case Control Collection (GoDARTS) was funded by The Wellcome Trust (072960/Z/03/Z, 084726/Z/08/Z, 084727/Z/08/Z, 085475/Z/08/Z, 085475/B/08/Z) and as part of the EU IMI-SUMMIT program.We acknowledge the following conflicts of interest: P-H.G. has received investigator-initiated research grants from Eli Lilly and Roche, is an advisory board member for AbbVie, AstraZeneca, Boehringer Ingelheim, Cebix, Eli Lilly, Janssen, Medscape, Merck Sharp & Dohme, Novartis, Novo Nordisk and Sanofi; and has received lecture fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly, Elo Water, Genzyme, Merck Sharp & Dohme, Medscape, Novo Nordisk and Sanofi. M.I.M. is a Wellcome Investigator and an NIHR Senior Investigator. The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. He serves on advisory panels for Pfizer, NovoNordisk, and Zoe Global; has received honoraria from Merck, Pfizer, NovoNordisk and Eli Lilly; has stock options in Zoe Global; and has received research funding from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier and Takeda. P.R. has received consultancy and/or speaking fees (to his institution) from AbbVie, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, MSD, Novo Nordisk and Sanofi Aventis and research grants from AstraZeneca and Novo Nordisk, and shares in Novo Nordisk.DATA AND SOFTWARE AVAILABILITYGWAS summary statistics for all ten DKD phenotypes and two adjustment models are available for download at the AMP-Type 2 Diabetes Knowledge Portal (), under “JDRF Diabetic Nephropathy Collaborative Research Initiative GWAS” datasets. Individual level genotype data cannot be shared for all cohorts due to restrictions set by study consents and by EU and national regulations, individual genotype data. Table of Contents (Supplemental Results)Table S1. Cohorts contributing to analyses.3Table S2. Characteristics of RASS participants. Categorical variables display counts and percentage. Continuous values are mean ± standard deviation.3Table S3. Multivariate analysis of association between rs55703767 and GBM width4Table S4: Look-up of the lead loci in GWAS on eGFR in the general population (Gorski et al., 2017).15Table S5: Look-up of the lead loci in GWAS in the SUMMIT consortium (van Zuydam et al., 2018).26Table S6: Association at lead loci stratified by HbA1c <7.5%.7Table S7. Association of rs55703767 with DN in DCCT/EDIC subgroups.8Table S8. Significant (P<0.05/18,222 genes tested = 2.74 × 10-6) gene level associations with diabetic kidney disease in MAGMA.9Table S9. Top nominally significant gene level associations (P < 1.0 x 10-5) with diabetic kidney disease in PASCAL.9Table S10: Significant gene set and pathway analysis results.10Table S11. eQTL associations and chromatin conformation interactions for the lead SNPs.11Table S12: Transcriptome-wide association analysis (TWAS) results with p<1×10-416Table S13: Pseudo-R2 of all SNPs across all GWAS as calculated by the McKelvey and Zavoina method.17Table S14(S13). Physicians and nurses at health care centers participating in the collection of FinnDiane patients.18Table S14 (S15): Members of the SUMMIT consortium.22Figure S1. Manhattan and QQ Plots for each case-control definition and covariate model (minimal and full)32Figure S2. Regional chromosomal location plots and forest plots by cohort of newly discovered DKD associations52Figure S3 (S2). Correlation of expression of COL4A3 with degree of fibrosis and eGFR in microdissected kidney samples.60Figure S4 (S3). Genotype – phenotype associations at the lead loci when stratified by mean HbA1c <7.5% in the FinnDiane study.61Figure S5 (S4): Genotype – phenotype associations at the lead rs55703767 (COL4A3) locus when stratified by mean HbA1c <7.5% in up to 3226 individuals with type 2 diabetes (T2D) from the GoDARTS.62Figure S6 (S6). Fishplots comparing significance and directionality between minimal and fully adjusted models for each of the 10 phenotype definitions.63Figure S7 (S5): Association at previously reported loci (p<5×10-8) for renal complications in individuals with diabetes.65Figure S8 (S7): Forest plots of the associations at the previously reported lead loci from the GENIE consortium with largely overlapping studies.66Figure S9 (S7): Meta-analysis results for the loci that have previously been associated with DKD, or with eGFR or AER in the general population67Figure S10 (S8). Expression of quantitative trait loci (eQTL) analysis in microdissected tubule samples.69Figure S11 (S9). Functional annotation of TAMM41.70Supplemental Methods: Cohort descriptions71References78REFERENCES ADDIN EN.REFLIST 1.Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2017 Estimates of Diabetes and Its Burden in the United States Background. in Atlanta, GA: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2017.2.Tuttle, K.R. et al. Diabetic kidney disease: a report from an ADA Consensus Conference. Am J Kidney Dis 64, 510-33 (2014).3.Krolewski, M., Eggers, P.W. & Warram, J.H. Magnitude of end-stage renal disease in IDDM: a 35 year follow-up study. Kidney Int 50, 2041-2046 (1996).4.Harjutsalo, V., Katoh, S., Sarti, C., Tajima, N. & Tuomilehto, J. Population-based assessment of familial clustering of diabetic nephropathy in type 1 diabetes. Diabetes 53, 2449-54 (2004).5.Quinn, M., Angelico, M.C., Warram, J.H. & Krolewski, A.S. Familial factors determine the development of diabetic nephropathy in patients with IDDM. Diabetologia 39, 940-5 (1996).6.Seaquist, E., Goetz, F., Rich, S. & Barbosa, J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 320, 1161-1165 (1989).7.Sandholm, N. et al. The Genetic Landscape of Renal Complications in Type 1 Diabetes. J Am Soc Nephrol 28, 557-574 (2017).8.Iyengar, S.K. et al. Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet 11, e1005352 (2015).9.Pattaro, C. et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun 7, 10023 (2016).10.Sandholm, N. et al. Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes. Diabetologia 57, 1143-53 (2014).11.Sandholm, N. et al. Chromosome 2q31.1 Associates with ESRD in Women with Type 1 Diabetes. Journal of the American Society of Nephrology 24, 1537-1543 (2013).12.Sandholm, N. et al. New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet 8, e1002921 (2012).13.van Zuydam, N.R. et al. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes 67, 1414-1427 (2018).14.Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. & Abecasis, G.R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet 44, 955-9 (2012).15.Fuchsberger, C., Abecasis, G.R. & Hinds, D.A. minimac2: faster genotype imputation. Bioinformatics 31, 782-4 (2015).16.Li, J. & Ji, L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) 95, 221-7 (2005).17.McKelvey, R.D. & Zavoina, W. A statistical model for the analysis of ordinal level dependent variables. The Journal of Mathematical Sociology 4, 103-120 (1975).18.Mauer, M. et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med 361, 40-51 (2009).19.Cohen, C.D., Frach, K., Schlondorff, D. & Kretzler, M. Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. Kidney Int 61, 133-40 (2002).20.Berthier, C.C. et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes 58, 469-77 (2009).21.Schmid, H. et al. Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes 55, 2993-3003 (2006).22.Ko, Y.A. et al. Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. Am J Hum Genet 100, 940-953 (2017).23.Qiu, C. et al. Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. Nat Med 24, 1721-1731 (2018).24.Park, J. et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360, 758-763 (2018).25.Bernstein, B.E. et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol 28, 1045-8 (2010).26.Barbeira, A.N. et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat Commun 9, 1825 (2018).27.Yagame, M. et al. Differential distribution of type IV collagen chains in patients with diabetic nephropathy in non-insulin-dependent diabetes mellitus. Nephron 70, 42-8 (1995).28.Caramori, M.L., Parks, A. & Mauer, M. Renal lesions predict progression of diabetic nephropathy in type 1 diabetes. J Am Soc Nephrol 24, 1175-81 (2013).29.Fufaa, G.D. et al. Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes. Clin J Am Soc Nephrol 11, 254-61 (2016).30.Mauer, M., Caramori, M.L., Fioretto, P. & Najafian, B. Glomerular structural-functional relationship models of diabetic nephropathy are robust in type 1 diabetic patients. Nephrol Dial Transplant 30, 918-23 (2015).31.Gorski, M. et al. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep 7, 45040 (2017).32.Thorn, L.M. et al. Metabolic syndrome in type 1 diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study). Diabetes Care 28, 2019-2024 (2005).33.Morris, A.D. et al. The diabetes audit and research in Tayside Scotland (DARTS) study: electronic record linkage to create a diabetes register. DARTS/MEMO Collaboration. BMJ 315, 524-8 (1997).34.Nathan, D.M. & Group, D.E.R. The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care 37, 9-16 (2014).35.The Diabetes Control and Complications Trial Research Group. Implementation of treatment protocols in the Diabetes Control and Complications Trial. Diabetes Care 18, 361-76 (1995).36.Blunsom, N.J., Gomez-Espinosa, E., Ashlin, T.G. & Cockcroft, S. Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1. Biochim Biophys Acta Mol Cell Biol Lipids 1863, 284-298 (2018).37.Tamura, Y. et al. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab 17, 709-18 (2013).38.Wang, S. et al. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 17, 2504-12 (2006).39.Sandholm, N. et al. Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes. Sci Rep 8, 12408 (2018).40.Lamparter, D., Marbach, D., Rueedi, R., Kutalik, Z. & Bergmann, S. Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics. PLoS Comput Biol 12, e1004714 (2016).41.de Leeuw, C.A., Mooij, J.M., Heskes, T. & Posthuma, D. MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol 11, e1004219 (2015).42.Bell, C.G. et al. Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Medical Genomics 3(2010).43.Sapienza, C. et al. DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy. Epigenetics 6, 20-8 (2011).44.Loo, Y.M. & Gale, M., Jr. Immune signaling by RIG-I-like receptors. Immunity 34, 680-92 (2011).45.Mollen, K.P. et al. Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock 26, 430-7 (2006).46.Mora, C. & Navarro, J.F. Inflammation and diabetic nephropathy. Curr Diab Rep 6, 463-8 (2006).47.Wada, J. & Makino, H. Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci (Lond) 124, 139-52 (2013).48.Lin, M. et al. Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Soc Nephrol 23, 86-102 (2012).49.Ma, J. et al. TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy. PLoS One 9, e97985 (2014).50.Colhoun, H.M. & Marcovecchio, M.L. Biomarkers of diabetic kidney disease. Diabetologia 61, 996-1011 (2018).51.McKnight, A.J. et al. Genetic polymorphisms in nitric oxide synthase 3 gene and implications for kidney disease: a meta-analysis. Am J Nephrol 32, 476-81 (2010).52.Prabhakar, S.S. Role of nitric oxide in diabetic nephropathy. Semin Nephrol 24, 333-44 (2004).53.Chasman, D.I. et al. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet 21, 5329-43 (2012).54.Swan, E.J., Maxwell, A.P. & McKnight, A.J. Distinct methylation patterns in genes that affect mitochondrial function are associated with kidney disease in blood-derived DNA from individuals with Type 1 diabetes. Diabet Med 32, 1110-5 (2015).55.Muller-Deile, J. et al. Podocytes regulate the glomerular basement membrane protein nephronectin by means of miR-378a-3p in glomerular diseases. Kidney Int 92, 836-849 (2017).56.Hodgin, J.B. et al. Identification of cross-species shared transcriptional networks of diabetic nephropathy in human and mouse glomeruli. Diabetes 62, 299-308 (2013).57.Zanetti, D. et al. Identification of 22 novel loci associated with urinary biomarkers of albumin, sodium, and potassium excretion. Kidney Int 95, 1197-1208 (2019).58.Holme, A. et al. Glomerular involvement in the arthrogryposis, renal dysfunction and cholestasis syndrome. Clin Kidney J 6, 183-8 (2013).59.Kleppel, M.M., Fan, W., Cheong, H.I. & Michael, A.F. Evidence for separate networks of classical and novel basement membrane collagen. Characterization of alpha 3(IV)-alport antigen heterodimer. J Biol Chem 267, 4137-42 (1992).60.Khoshnoodi, J., Pedchenko, V. & Hudson, B.G. Mammalian collagen IV. Microsc Res Tech 71, 357-70 (2008).61.Kashtan, C.E. et al. Alport syndrome: a unified classification of genetic disorders of collagen IV alpha345: a position paper of the Alport Syndrome Classification Working Group. Kidney Int 93, 1045-1051 (2018).62.Xie, J. et al. COL4A3 mutations cause focal segmental glomerulosclerosis. J Mol Cell Biol 6, 498-505 (2014).63.Parkin, J.D. et al. Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes. Hum Mutat 32, 127-43 (2011).64.Guan, M. et al. Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans. Hum Genet 135, 1251-1262 (2016).65.Schofield, E.C. et al. CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets. Bioinformatics 32, 2511-3 (2016).66.Alves, F. et al. Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene 10, 609-18 (1995).67.Vogel, W., Gish, G.D., Alves, F. & Pawson, T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1, 13-23 (1997).68.Dorison, A. & Chantziantoniou, C. DDR1: A major player in renal diseases. Cell Adh Migr 12, 299-304 (2018).69.Gross, O. et al. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol 29, 346-56 (2010).70.Kerroch, M. et al. Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis. FASEB J 26, 4079-91 (2012).71.Mifsud, B. et al. Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C. Nat Genet 47, 598-606 (2015).72.Selman, L. & Hansen, S. Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1). Immunobiology 217, 851-63 (2012).73.Hansen, S. et al. Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity. J Immunol 185, 6096-104 (2010).74.Farrar, C.A. et al. Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest 126, 1911-25 (2016).75.Rooryck, C. et al. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet 43, 197-203 (2011).76.Walsh, D.W., Godson, C., Brazil, D.P. & Martin, F. Extracellular BMP-antagonist regulation in development and disease: tied up in knots. Trends Cell Biol 20, 244-56 (2010).77.Zeisberg, M., Shah, A.A. & Kalluri, R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem 280, 8094-100 (2005).78.Vukicevic, S., Kopp, J.B., Luyten, F.P. & Sampath, T.K. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci U S A 93, 9021-6 (1996).79.Luo, G. et al. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9, 2808-20 (1995).80.Higgins, D.F. et al. BMP7-induced-Pten inhibits Akt and prevents renal fibrosis. Biochim Biophys Acta Mol Basis Dis 1863, 3095-3104 (2017).81.Roxburgh, S.A. et al. Allelic depletion of grem1 attenuates diabetic kidney disease. Diabetes 58, 1641-50 (2009).82.Dolan, V. et al. Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy. Am J Kidney Dis 45, 1034-9 (2005).83.McMahon, R. et al. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. J Biol Chem 275, 9901-4 (2000).84.Afkarian, M. et al. Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. Physiol Rep 2, e12010 (2014).TABLES Table 1. Loci associated with DKD at study-wide (P<6.76×10-9, bold) and genome-wide (P<5×10-8) significance. Common variants and/or genes with relevant kidney biology are reported in the top half of the table. Uncommon variants (MAF < 2%) with no known relevant kidney biology are reported in the bottom half of the table. Genes are annotated as follows: missense variant in the indicated gene (M); intronic, synonymous, or noncoding variant in the indicated gene (G); gene nearest to lead variant (N); gene has relevant kidney (B). Chr, chromosome; pos, position; EAF, effect allele frequency; OR, odds ratio; min, minimally adjusted covariate model; full, fully adjusted covariate model.SNPChr:posEffect alleleOther alleleEAFNotable gene(s)PhenotypeORminP-valueminORfullP-valuefullrs557037672:228121101TG0.206COL4A3(M, B, N)DN0.795.34×10-120.788.19×10-11??????All vs. ctrl0.833.88×10-100.849.68×10-9??????CKD+DN0.775.30×10-90.763.77×10-8??????Macro0.789.28×10-90.779.38×10-9rs126159702:3745215GA0.133COLEC11 (B)ALLC (N, G)CKD0.769.43×10-90.771.60×10-7rs1428232823:11910635GA0.011TAMM41(N, B)Micro6.738.32×10-109.181.13×10-11rs1456811684:174500806GA0.014HAND2-AS1 (N, G, B)?Micro5.532.06×10-77.475.40×10-9rs1181248436:30887465TC0.011DDR1 (B)VARS2 (G)Micro3.794.42×10-83.993.37×10-8rs772730767:99728546TC0.008MBLAC1(N, B)Micro9.161.04×10-87.10 2.28×10-7rs5511917078:128100029CAC0.122PRNCR1(N)ESRD vs. macro1.704.39×10-81.713.15×10-6rs6198341014:26004712TC0.213STXBP6(N)Micro0.799.84×10-80.783.06×10-8rs14443440420:55837263TC0.011BMP7(N, G, B)Micro6.782.67×10-96.664.65×10-9???????????rs1150611733:926345AT0.014LINC01266(N)ESRD vs. ctrl9.404.07×10-88.344.08×10-5rs1162160593:36566312AC0.016STAC(N, G)ESRD vs. non-ESRD8.731.37×10-811.781.41×10-4rs1914496394:71358776AT0.005MUC7(N)DN32.421.32×10-832.472.09×10-8rs1496418525:121774582TG0.012SNCAIP(N, G)CKD extreme9.011.37×10-8------rs18393729411:16937846GT0.007PLEKHA7(N, G)Micro17.221.65×10-823.622.10×10-6rs11355420614:73740250AG0.012PAPLN(N, G)Macro4.605.39×10-710.428.46×10-9rs18529910918:1811108TC0.007intergenicCKD20.751.28×10-844.754.99×10-7 ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- university of minnesota college of education
- university of minnesota school of social work
- wharton school of the university of pennsylvania
- cost of university of scranton
- university of minnesota school of education
- university of scranton cost of attendance
- university of south florida college of medicine
- university of minnesota masters of social work
- ecampus of university of phoenix
- university of minnesota college of continuing education
- university of illinois college of nursing
- university of north texas college of nursing