Lippincott Williams & Wilkins



Supplemental Content 6Table S3. Rates of persistent postoperative opioid use in opioid na?ve population based on definitions obtained from systematic literature review.DefinitionIncidence of Persistent UseN=162,803Incidence of Persistent Use (Strict)N=156,275Prescriptions at Distinct TimepointOpioid prescription beyond 30 days after date of surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGFmZm9yZDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+

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ADDIN EN.CITE.DATA 123,442 (14.4%)22,026 (14.1%)Opioid consumed 6 weeks post-operatively (patient reported) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmFjZTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 4-87,616 (4.7%)7,063 (4.5%)1) Filled prescription within 1 to 90 days after discharge; and 2) Filled at least one additional opioid prescription between 91 and 180 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 14,151,061 (0.7%)944 (0.6%)Opioid use, based on questionnaire, between 90 and 120 days after surgery ADDIN EN.CITE <EndNote><Cite><Author>Stark</Author><Year>2017</Year><RecNum>511</RecNum><DisplayText><style face="superscript">16</style></DisplayText><record><rec-number>511</rec-number><foreign-keys><key app="EN" db-id="vawadfaz6xts0ke0tr3xwtp8tveas9a5r0wd" timestamp="1553808100">511</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>N. Stark</author><author>S. Kerr</author><author>J. Stevens</author></authors></contributors><titles><title>Prevalence and predictors of persistent post-surgical opioid use: a prospective observational cohort study</title><secondary-title>Anaesthesia and intensive care</secondary-title></titles><periodical><full-title>Anaesthesia and intensive care</full-title></periodical><pages>700</pages><volume>45</volume><number>6</number><keywords><keyword>Adolescent,Adult,Aged,Aged, 80 and over,*Analgesics, Opioid/tu [Therapeutic Use],Female,Humans,Logistic Models,Male,Middle Aged,*Pain, Postoperative/dt [Drug Therapy],Prevalence,Prospective Studies,Young Adult</keyword></keywords><dates><year>2017</year></dates><pub-location>Australia</pub-location><isbn>0310-057X,0310-057X</isbn><urls></urls></record></Cite></EndNote>163,149 (1.9%)2,906 (1.9%)1) Filled prescription within 30 days before surgery and 30 days after discharge; 2) Filled at least one additional opioid prescription between 90 and 120 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjdXNhPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48

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ADDIN EN.CITE.DATA 195,698 (3.5%)5,192 (3.4%)Filled within 60 days of the 1-year anniversary date (eg, 305-425 days after the index date) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbGFtPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 231072(0.6%)919 (0.6%)90 days of continuous use or at least 120 days of non-continuous use (within 275 days, excluding the first 90 days)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYW5zZW48L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS

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ADDIN EN.CITE.DATA 24,25461 (0.3%)388 (0.2%)Prescribed opioids for >6 contiguous months after surgery (followed for 24 months post-operatively)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2xpdHplcjwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

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ADDIN EN.CITE.DATA 2672 (0.0%)56 (0.0%)Patient reported continuous consumption of opioid (with no gaps >5 days) in the 150 days after dischargePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJyb2xsPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48

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ADDIN EN.CITE.DATA 34,35286 (0.2%)236 (0.2%)1) Filled prescription within 15 to 90 days after discharge and filled at least one additional opioid prescription between 91 and 180 days after surgery; and, 2) either A) 1150 OMEs total dose OR B) 39 days supplied and 2 filled prescriptions ADDIN EN.CITE <EndNote><Cite><Author>Swenson</Author><Year>2018</Year><RecNum>513</RecNum><DisplayText><style face="superscript">36</style></DisplayText><record><rec-number>513</rec-number><foreign-keys><key app="EN" db-id="vawadfaz6xts0ke0tr3xwtp8tveas9a5r0wd" timestamp="1553808100">513</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Swenson, C. W.</author><author>Seiler, K.</author><author>Kamdar, N.</author><author>Morgan, D.</author></authors></contributors><auth-address>C.W. Swenson, University of Michigan, Ann Arbor, MI, United States</auth-address><titles><title>Prevalence of new persistent opioid use among opioid naive women undergoing hysterectomy</title><secondary-title>American Journal of Obstetrics and Gynecology</secondary-title><tertiary-title>44th Annual Meeting of the Society Of Gynecologic Surgeons, SGS 2018. United States.</tertiary-title></titles><periodical><full-title>American Journal of Obstetrics and Gynecology</full-title></periodical><pages>S885</pages><volume>218</volume><number>2 Supplement 2</number><keywords><keyword>adult,age,anesthesia,anxiety,bivariate analysis,Black person,*cancer surgery,chronic pain,Current Procedural Terminology,depression,diagnosis,disease simulation,education,female,female genital tract cancer,human,*hysterectomy,International Classificatio</keyword></keywords><dates><year>2018</year></dates><pub-location>Netherlands</pub-location><publisher>Mosby Inc.</publisher><isbn>1097-6868</isbn><urls></urls></record></Cite></EndNote>36535 (0.3%)420 (0.3%)Works Cited ADDIN EN.REFLIST 1.Stafford C, Francone T, Roberts PL, Ricciardi R: What factors are associated with increased risk for prolonged postoperative opioid usage after colorectal surgery? 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