Lippincott Williams & Wilkins
Supplemental Content 6Table S3. Rates of persistent postoperative opioid use in opioid na?ve population based on definitions obtained from systematic literature review.DefinitionIncidence of Persistent UseN=162,803Incidence of Persistent Use (Strict)N=156,275Prescriptions at Distinct TimepointOpioid prescription beyond 30 days after date of surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGFmZm9yZDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdGFmZm9yZDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+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ADDIN EN.CITE.DATA 123,442 (14.4%)22,026 (14.1%)Opioid consumed 6 weeks post-operatively (patient reported) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmFjZTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmFjZTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJl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ADDIN EN.CITE.DATA 2,3959 (0.6%)845 (0.5%)Filled at least one opioid prescription between 90 and 180 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYW5jaWVubmU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYW5jaWVubmU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFy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ADDIN EN.CITE.DATA 4-87,616 (4.7%)7,063 (4.5%)1) Filled prescription within 1 to 90 days after discharge; and 2) Filled at least one additional opioid prescription between 91 and 180 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGFya2U8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA 95,761 (3.5%)5,355 (3.4%)1) Filled prescription within 30 days before surgery and 14 days after discharge; 2) Filled at least one additional opioid prescription between 90 and 180 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc29uPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc29uPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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ADDIN EN.CITE.DATA 10-125,685 (3.5%)5,132 (3.3%)Filled at least one opioid prescription overlapping 90 or 180 daysPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW5kZXN0cmFuZDwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW5kZXN0cmFuZDwvQXV0aG9yPjxZZWFyPjIwMTU8L1ll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 EN.CITE.DATA 131,854 (1.1%)1,663 (1.1%)Opioid consumption at time of interview (180 days postoperatively) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb2VzbGluZzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb2VzbGluZzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+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ADDIN EN.CITE.DATA 14,151,061 (0.7%)944 (0.6%)Opioid use, based on questionnaire, between 90 and 120 days after surgery ADDIN EN.CITE <EndNote><Cite><Author>Stark</Author><Year>2017</Year><RecNum>511</RecNum><DisplayText><style face="superscript">16</style></DisplayText><record><rec-number>511</rec-number><foreign-keys><key app="EN" db-id="vawadfaz6xts0ke0tr3xwtp8tveas9a5r0wd" timestamp="1553808100">511</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>N. Stark</author><author>S. Kerr</author><author>J. Stevens</author></authors></contributors><titles><title>Prevalence and predictors of persistent post-surgical opioid use: a prospective observational cohort study</title><secondary-title>Anaesthesia and intensive care</secondary-title></titles><periodical><full-title>Anaesthesia and intensive care</full-title></periodical><pages>700</pages><volume>45</volume><number>6</number><keywords><keyword>Adolescent,Adult,Aged,Aged, 80 and over,*Analgesics, Opioid/tu [Therapeutic Use],Female,Humans,Logistic Models,Male,Middle Aged,*Pain, Postoperative/dt [Drug Therapy],Prevalence,Prospective Studies,Young Adult</keyword></keywords><dates><year>2017</year></dates><pub-location>Australia</pub-location><isbn>0310-057X,0310-057X</isbn><urls></urls></record></Cite></EndNote>163,149 (1.9%)2,906 (1.9%)1) Filled prescription within 30 days before surgery and 30 days after discharge; 2) Filled at least one additional opioid prescription between 90 and 120 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjdXNhPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXJjdXNhPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48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ADDIN EN.CITE.DATA 172,359 (1.4%)2,116 (1.4%)Filled at least one opioid prescription between 90 and 365 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdWVsbGVyPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NdWVsbGVyPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48
UmVjTnVtPjIxNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi
PjE4PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjE3PC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idmF3YWRmYXo2eHRzMGtlMHRy
M3h3dHA4dHZlYXM5YTVyMHdkIiB0aW1lc3RhbXA9IjE1MjI1MTg0OTYiPjIxNzwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TXVlbGxlciwgSy4gRy48L2F1dGhvcj48YXV0
aG9yPk1lbXRzb3VkaXMsIFMuIEcuPC9hdXRob3I+PGF1dGhvcj5NYXJpYW5vLCBFLiBSLjwvYXV0
aG9yPjxhdXRob3I+QmFrZXIsIEwuIEMuPC9hdXRob3I+PGF1dGhvcj5NYWNrZXksIFMuPC9hdXRo
b3I+PGF1dGhvcj5TdW4sIEUuIEMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh
dXRoLWFkZHJlc3M+RnJvbSAqRHVrZSBVbml2ZXJzaXR5LCBEdXJoYW0sIE5vcnRoIENhcm9saW5h
OyBkYWdnZXJEZXBhcnRtZW50IG9mIEFuZXN0aGVzaW9sb2d5LCBIb3NwaXRhbCBmb3IgU3BlY2lh
bCBTdXJnZXJ5LCBOZXcgWW9yaywgTmV3IFlvcms7IGRvdWJsZSBkYWdnZXJEZXBhcnRtZW50IG9m
IEFuZXN0aGVzaW9sb2d5LCBQZXJpb3BlcmF0aXZlIGFuZCBQYWluIE1lZGljaW5lLCBTdGFuZm9y
ZCBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQgVW5pdmVyc2l0eSwgQ2Fs
aWZvcm5pYTsgc2VjdGlvbiBzaWduQW5lc3RoZXNpb2xvZ3kgYW5kIFBlcmlvcGVyYXRpdmUgQ2Fy
ZSBTZXJ2aWNlLCBWZXRlcmFucyBBZmZhaXJzLCBQYWxvIEFsdG8gSGVhbHRoIENhcmUgU3lzdGVt
LCBQYWxvIEFsdG8sIENhbGlmb3JuaWE7IHx8RGVwYXJ0bWVudCBvZiBIZWFsdGggUmVzZWFyY2gg
YW5kIFBvbGljeSwgU3RhbmZvcmQgVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIFN0YW5m
b3JkIFVuaXZlcnNpdHksIFN0YW5mb3JkLCBDYWxpZm9ybmlhOyBhbmQgcGFyYWdyYXBoIHNpZ25O
YXRpb25hbCBCdXJlYXUgb2YgRWNvbm9taWMgUmVzZWFyY2gsIENhbWJyaWRnZSwgTWFzc2FjaHVz
ZXR0cy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5MYWNrIG9mIEFzc29jaWF0aW9uIEJl
dHdlZW4gdGhlIFVzZSBvZiBOZXJ2ZSBCbG9ja2FkZSBhbmQgdGhlIFJpc2sgb2YgUGVyc2lzdGVu
dCBPcGlvaWQgVXNlIEFtb25nIFBhdGllbnRzIFVuZGVyZ29pbmcgU2hvdWxkZXIgQXJ0aHJvcGxh
c3R5OiBFdmlkZW5jZSBGcm9tIHRoZSBNYXJrZXRzY2FuIERhdGFiYXNlPC90aXRsZT48c2Vjb25k
YXJ5LXRpdGxlPkFuZXN0aCBBbmFsZzwvc2Vjb25kYXJ5LXRpdGxlPjxzaG9ydC10aXRsZT5Fdmlk
ZW5jZSBGcm9tIHRoZSBNYXJrZXRzY2FuIERhdGFiYXNlPC9zaG9ydC10aXRsZT48L3RpdGxlcz48
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5BbmVzdGggQW5hbGc8L2Z1bGwtdGl0bGU+PC9wZXJpb2Rp
Y2FsPjxwYWdlcz4xMDE0LTEwMjA8L3BhZ2VzPjx2b2x1bWU+MTI1PC92b2x1bWU+PG51bWJlcj4z
PC9udW1iZXI+PGVkaXRpb24+MjAxNy8wNy8yNjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+
QXJ0aHJvcGxhc3R5LCBSZXBsYWNlbWVudCwgU2hvdWxkZXIvKnRyZW5kczwva2V5d29yZD48a2V5
d29yZD5EYXRhYmFzZXMsIEZhY3R1YWwvKnRyZW5kczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8
L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+
PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVydmUgQmxvY2svKnRyZW5k
czwva2V5d29yZD48a2V5d29yZD5PcGlvaWQtUmVsYXRlZCBEaXNvcmRlcnMvZGlhZ25vc2lzL2Vw
aWRlbWlvbG9neS8qcHJldmVudGlvbiAmYW1wOyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPlBh
aW4sIFBvc3RvcGVyYXRpdmUvZGlhZ25vc2lzL2VwaWRlbWlvbG9neS8qcHJldmVudGlvbiAmYW1w
OyBjb250cm9sPC9rZXl3b3JkPjxrZXl3b3JkPlBvc3RvcGVyYXRpdmUgQ29tcGxpY2F0aW9ucy9k
aWFnbm9zaXMvZXBpZGVtaW9sb2d5L3ByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48
a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0
b3JzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTc8L3llYXI+PHB1Yi1kYXRl
cz48ZGF0ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI2LTc1OTggKEVs
ZWN0cm9uaWMpJiN4RDswMDAzLTI5OTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI4
NzQyNzc3PC9hY2Nlc3Npb24tbnVtPjxsYWJlbD5yMDA5NjQ8L2xhYmVsPjx1cmxzPjxyZWxhdGVk
LXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yODc0Mjc3Nzwv
dXJsPjwvcmVsYXRlZC11cmxzPjxwZGYtdXJscz48dXJsPmZpbGU6Ly9sb2NhbGhvc3QvVXNlcnMv
bmFoZWVkaml2cmFqL0Ryb3Bib3gvQXBwcy9QYXBlcnMzL0xpYnJhcnkucGFwZXJzMy9GaWxlcy85
RC85RDcyNzNEMS01QjlFLTRBRjQtQUQxMS1GRjUzQzIzRDI3RkQucGRmPC91cmw+PC9wZGYtdXJs
cz48L3VybHM+PGN1c3RvbTM+cGFwZXJzMzovL3B1YmxpY2F0aW9uL3V1aWQvNDE3Qjk1NzktNzk3
QS00Q0FGLUJEMTAtOEYxMUVFN0FDRTgyPC9jdXN0b20zPjxlbGVjdHJvbmljLXJlc291cmNlLW51
bT4xMC4xMjEzL0FORS4wMDAwMDAwMDAwMDAyMDMxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48
bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA 1819,477 (11.9%)18,284 (11.7%)Filled > 1 opioid prescription >90 days after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5nPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW5nPC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 195,698 (3.5%)5,192 (3.4%)Filled within 60 days of the 1-year anniversary date (eg, 305-425 days after the index date) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbGFtPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbGFtPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 20 10,130 (6.2%)9,480 (6.1%)Opioid use at 12-months (365 days) post-operatively ADDIN EN.CITE <EndNote><Cite><Author>Pugely</Author><Year>2018</Year><RecNum>518</RecNum><DisplayText><style face="superscript">21</style></DisplayText><record><rec-number>518</rec-number><foreign-keys><key app="EN" db-id="vawadfaz6xts0ke0tr3xwtp8tveas9a5r0wd" timestamp="1553808100">518</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pugely, A. J.</author><author>Bedard, N. A.</author><author>Kalakoti, P.</author><author>Hendrickson, N. R.</author><author>Shillingford, J. N.</author><author>Laratta, J. L.</author><author>Saifi, C.</author><author>Lehman, R. A.</author><author>Riew, K. D.</author></authors></contributors><auth-address>A.J. Pugely, Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, United States. E-mail: andrew-pugely@uiowa.edu</auth-address><titles><title>Opioid use following cervical spine surgery: trends and factors associated with long-term use</title><secondary-title>Spine Journal</secondary-title></titles><periodical><full-title>Spine Journal</full-title></periodical><keywords><keyword>adult,*arthrodesis,article,driver,drug dependence,drug withdrawal,female,human,low back pain,major clinical study,observational study,outcome assessment,postoperative period,*prescription,*register,retrospective study,risk assessment,*spine surgery,stud</keyword></keywords><dates><year>2018</year></dates><pub-location>United States</pub-location><publisher>Elsevier Inc. (E-mail: usjcs@)</publisher><isbn>1529-9430,1878-1632</isbn><urls><related-urls><url> (0.8%)1,247 (0.8%)Multiple Days of PrescribingFilled at 3 distinct time points: 1) 28 to 56 days, 2) 90 to 180 days, and 3) 300 to 365 days after surgery (or first two time intervals if the patient had an event (death and/or graft loss) between three and 12 months)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdWxzaHJlc3RoYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdWxzaHJlc3RoYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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ADDIN EN.CITE.DATA 22230(0.1%)176 (0.1%)60 days of non-continuous prescriptions filled (within 275 days, excluding the first 90 days)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZW50PC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZW50PC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA 231072(0.6%)919 (0.6%)90 days of continuous use or at least 120 days of non-continuous use (within 275 days, excluding the first 90 days)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYW5zZW48L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYW5zZW48L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA 24,25461 (0.3%)388 (0.2%)Prescribed opioids for >6 contiguous months after surgery (followed for 24 months post-operatively)PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2xpdHplcjwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+
PFJlY051bT4yNDg8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0
Ij4yNjwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjI0ODwvcmVjLW51
bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InZhd2FkZmF6Nnh0czBrZTB0
cjN4d3RwOHR2ZWFzOWE1cjB3ZCIgdGltZXN0YW1wPSIxNTIyNTE4NDk2Ij4yNDg8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlBvbGl0emVyLCBDLiBTLjwvYXV0aG9yPjxh
dXRob3I+S2lsZG93LCBCLiBKLjwvYXV0aG9yPjxhdXRob3I+R29sdHosIEQuIEUuPC9hdXRob3I+
PGF1dGhvcj5HcmVlbiwgQy4gTC48L2F1dGhvcj48YXV0aG9yPkJvbG9nbmVzaSwgTS4gUC48L2F1
dGhvcj48YXV0aG9yPlNleWxlciwgVC4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv
cnM+PGF1dGgtYWRkcmVzcz5EdWtlIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBNYXJ5
IER1a2UgQmlkZGxlIFRyZW50IFNlbWFucyBDZW50ZXIgZm9yIEhlYWx0aCBFZHVjYXRpb24sIER1
a2UgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBHcmVlbnNwYWNlLCBEdXJoYW0sIE5vcnRoIENh
cm9saW5hLiYjeEQ7RGVwYXJ0bWVudCBvZiBPcnRob3BhZWRpYyBTdXJnZXJ5LCBEdWtlIFVuaXZl
cnNpdHkgTWVkaWNhbCBDZW50ZXIsIER1cmhhbSwgTm9ydGggQ2Fyb2xpbmEuJiN4RDtEZXBhcnRt
ZW50IG9mIEJpb3N0YXRpc3RpY3MgYW5kIEJpb2luZm9ybWF0aWNzLCBEdWtlIENsaW5pY2FsIFJl
c2VhcmNoIEluc3RpdHV0ZSwgRHVrZSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEdXJoYW0s
IE5vcnRoIENhcm9saW5hLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyZW5kcyBpbiBP
cGlvaWQgVXRpbGl6YXRpb24gQmVmb3JlIGFuZCBBZnRlciBUb3RhbCBLbmVlIEFydGhyb3BsYXN0
eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFydGhyb3BsYXN0eTwvc2Vjb25kYXJ5LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQXJ0aHJvcGxhc3R5PC9mdWxsLXRp
dGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MS04PC9wYWdlcz48ZWRpdGlvbj4yMDE3LzEyLzA1PC9l
ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5uYXJjb3RpY3M8L2tleXdvcmQ+PGtleXdvcmQ+b3Bp
b2lkczwva2V5d29yZD48a2V5d29yZD5wYWluPC9rZXl3b3JkPjxrZXl3b3JkPnJpc2sgZmFjdG9y
czwva2V5d29yZD48a2V5d29yZD50b3RhbCBrbmVlIGFydGhyb3BsYXN0eTwva2V5d29yZD48a2V5
d29yZD50cmVuZHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNzwveWVhcj48
cHViLWRhdGVzPjxkYXRlPk5vdiAxNDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxwdWJsaXNo
ZXI+RWxzZXZpZXIgTHRkPC9wdWJsaXNoZXI+PGlzYm4+MTUzMi04NDA2IChFbGVjdHJvbmljKSYj
eEQ7MDg4My01NDAzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yOTE5ODg3MTwvYWNj
ZXNzaW9uLW51bT48bGFiZWw+cjAwOTc0PC9sYWJlbD48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+
aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjkxOTg4NzE8L3VybD48L3JlbGF0
ZWQtdXJscz48cGRmLXVybHM+PHVybD5maWxlOi8vbG9jYWxob3N0L1VzZXJzL25haGVlZGppdnJh
ai9Ecm9wYm94L0FwcHMvUGFwZXJzMy9MaWJyYXJ5LnBhcGVyczMvRmlsZXMvMUUvMUUyMTRBQjgt
QkVBNS00QkFDLTlBMjItMTU1QUY0NkY2MERBLnBkZjwvdXJsPjwvcGRmLXVybHM+PC91cmxzPjxj
dXN0b20zPnBhcGVyczM6Ly9wdWJsaWNhdGlvbi91dWlkL0FFOEVBQkMxLTQwOUYtNDIwNS05ODUy
LTdERTlDNzRGMTEyNTwvY3VzdG9tMz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9q
LmFydGguMjAxNy4xMC4wNjA8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0
ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2xpdHplcjwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+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ADDIN EN.CITE.DATA 2672 (0.0%)56 (0.0%)Patient reported continuous consumption of opioid (with no gaps >5 days) in the 150 days after dischargePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJyb2xsPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJyb2xsPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48
UmVjTnVtPjIwNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD48c3R5bGUgZmFjZT0ic3VwZXJzY3JpcHQi
PjI3PC9zdHlsZT48L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MjA3PC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idmF3YWRmYXo2eHRzMGtlMHRy
M3h3dHA4dHZlYXM5YTVyMHdkIiB0aW1lc3RhbXA9IjE1MjI1MTg0OTYiPjIwNzwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2Fycm9sbCwgSS48L2F1dGhvcj48YXV0aG9y
PkJhcmVsa2EsIFAuPC9hdXRob3I+PGF1dGhvcj5XYW5nLCBDLiBLLjwvYXV0aG9yPjxhdXRob3I+
V2FuZywgQi4gTS48L2F1dGhvcj48YXV0aG9yPkdpbGxlc3BpZSwgTS4gSi48L2F1dGhvcj48YXV0
aG9yPk1jQ3VlLCBSLjwvYXV0aG9yPjxhdXRob3I+WW91bmdlciwgSi4gVy48L2F1dGhvcj48YXV0
aG9yPlRyYWZ0b24sIEouPC9hdXRob3I+PGF1dGhvcj5IdW1waHJleXMsIEsuPC9hdXRob3I+PGF1
dGhvcj5Hb29kbWFuLCBTLiBCLjwvYXV0aG9yPjxhdXRob3I+RGlyYmFzLCBGLjwvYXV0aG9yPjxh
dXRob3I+V2h5dGUsIFIuIEkuPC9hdXRob3I+PGF1dGhvcj5Eb25pbmd0b24sIEouIFMuPC9hdXRo
b3I+PGF1dGhvcj5DYW5ub24sIFcuIEIuPC9hdXRob3I+PGF1dGhvcj5NYWNrZXksIFMuIEMuPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBv
ZiBBbmVzdGhlc2lhLCBEaXZpc2lvbiBvZiBQYWluIE1hbmFnZW1lbnQsIFN0YW5mb3JkIFVuaXZl
cnNpdHksIFBhbG8gQWx0bywgQ0EgOTQwMzUsIFVTQS4gaXJjMzlAcGFpbi5zdGFuZm9yZC5lZHU8
L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BIHBpbG90IGNvaG9ydCBzdHVkeSBvZiB0aGUg
ZGV0ZXJtaW5hbnRzIG9mIGxvbmdpdHVkaW5hbCBvcGlvaWQgdXNlIGFmdGVyIHN1cmdlcnk8L3Rp
dGxlPjxzZWNvbmRhcnktdGl0bGU+QW5lc3RoIEFuYWxnPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs
ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW5lc3RoIEFuYWxnPC9mdWxsLXRpdGxlPjwvcGVy
aW9kaWNhbD48cGFnZXM+Njk0LTcwMjwvcGFnZXM+PHZvbHVtZT4xMTU8L3ZvbHVtZT48bnVtYmVy
PjM8L251bWJlcj48ZWRpdGlvbj4yMDEyLzA2LzI2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29y
ZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZmZlY3Q8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwv
a2V5d29yZD48a2V5d29yZD5BbmFsZ2VzaWNzLCBPcGlvaWQvKnRoZXJhcGV1dGljIHVzZTwva2V5
d29yZD48a2V5d29yZD5Db2hvcnQgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9u
L3BoeXNpb3BhdGhvbG9neTwva2V5d29yZD48a2V5d29yZD5GZWFyPC9rZXl3b3JkPjxrZXl3b3Jk
PkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TG9uZ2l0
dWRpbmFsIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N
aWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5NdWx0aXZhcmlhdGUgQW5hbHlzaXM8L2tleXdv
cmQ+PGtleXdvcmQ+T3Bpb2lkLVJlbGF0ZWQgRGlzb3JkZXJzLypldGlvbG9neTwva2V5d29yZD48
a2V5d29yZD5QYWluLCBQb3N0b3BlcmF0aXZlLypkcnVnIHRoZXJhcHk8L2tleXdvcmQ+PGtleXdv
cmQ+UGlsb3QgUHJvamVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+U2VsZiBDb25jZXB0PC9rZXl3b3Jk
PjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y
MDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+
PGlzYm4+MTUyNi03NTk4IChFbGVjdHJvbmljKSYjeEQ7MDAwMy0yOTk5IChMaW5raW5nKTwvaXNi
bj48YWNjZXNzaW9uLW51bT4yMjcyOTk2MzwvYWNjZXNzaW9uLW51bT48bGFiZWw+cjAxMDAyPC9s
YWJlbD48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv
di9wdWJtZWQvMjI3Mjk5NjM8L3VybD48L3JlbGF0ZWQtdXJscz48cGRmLXVybHM+PHVybD5maWxl
Oi8vbG9jYWxob3N0L1VzZXJzL25haGVlZGppdnJhai9Ecm9wYm94L0FwcHMvUGFwZXJzMy9MaWJy
YXJ5LnBhcGVyczMvRmlsZXMvMDYvMDY1MjA2OEMtMDZGMi00M0NGLTg0QkItRjdCOEEyQTA1Mjkz
LnBkZjwvdXJsPjwvcGRmLXVybHM+PC91cmxzPjxjdXN0b20zPnBhcGVyczM6Ly9wdWJsaWNhdGlv
bi91dWlkL0RGNTExNzIyLTlCQTktNDAzOS1BMDkxLTU5QkNDQkIxNjk2MzwvY3VzdG9tMz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTIxMy9BTkUuMGIwMTNlMzE4MjVjMDQ5ZjwvZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwv
Q2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA 27<5 (0%)<5(0%)Opioids prescribed uninterrupted for greater than 3 months after surgeryPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb3pldDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl
Y051bT4yMzk8L1JlY051bT48RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4y
ODwvc3R5bGU+PC9EaXNwbGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjIzOTwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9InZhd2FkZmF6Nnh0czBrZTB0cjN4
d3RwOHR2ZWFzOWE1cjB3ZCIgdGltZXN0YW1wPSIxNTIyNTE4NDk2Ij4yMzk8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJvemV0LCBJLjwvYXV0aG9yPjxhdXRob3I+Tmlz
aGlvLCBJLjwvYXV0aG9yPjxhdXRob3I+Um9iYmVydHplLCBSLjwvYXV0aG9yPjxhdXRob3I+Um90
dGVyLCBELjwvYXV0aG9yPjxhdXRob3I+Q2hhbnNreSwgSC48L2F1dGhvcj48YXV0aG9yPkhlcm5h
bmRleiwgQS4gVi48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVz
cz5Gcm9tIHRoZSAqRGVwYXJ0bWVudCBvZiBBbmVzdGhlc2lvbG9neSBhbmQgUGFpbiBNZWRpY2lu
ZSwgVW5pdmVyc2l0eSBvZiBXYXNoaW5ndG9uOyBkYWdnZXJEZXBhcnRtZW50IG9mIFZldGVyYW5z
IEFmZmFpcnMsIFB1Z2V0IFNvdW5kIEhlYWx0aCBDYXJlIFN5c3RlbSwgU2VhdHRsZSwgV2FzaGlu
Z3RvbjsgYW5kIGRvdWJsZSBkYWdnZXJEZXBhcnRtZW50IG9mIFF1YW50aXRhdGl2ZSBIZWFsdGgg
U2NpZW5jZXMsIEhlYWx0aCBPdXRjb21lcyBhbmQgQ2xpbmljYWwgRXBpZGVtaW9sb2d5LCBMZXJu
ZXIgUmVzZWFyY2ggSW5zdGl0dXRlLCBDbGV2ZWxhbmQgQ2xpbmljLCBDbGV2ZWxhbmQsIE9oaW8u
PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UHJvbG9uZ2VkIG9waW9pZCB1c2UgYWZ0ZXIg
a25lZSBhcnRocm9zY29weSBpbiBtaWxpdGFyeSB2ZXRlcmFuczwvdGl0bGU+PHNlY29uZGFyeS10
aXRsZT5BbmVzdGggQW5hbGc8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48
ZnVsbC10aXRsZT5BbmVzdGggQW5hbGc8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz40
NTQtOTwvcGFnZXM+PHZvbHVtZT4xMTk8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlv
bj4yMDE0LzA3LzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48
a2V5d29yZD5BZ2UgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5BbmFsZ2VzaWNzLCBPcGlvaWQv
KmFkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZTwva2V5d29yZD48a2V5d29yZD5BcnRocm9zY29w
eS8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkNocm9uaWMgUGFpbi9kaWFnbm9z
aXMvKmRydWcgdGhlcmFweS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RHJ1ZyBBZG1p
bmlzdHJhdGlvbiBTY2hlZHVsZTwva2V5d29yZD48a2V5d29yZD5EcnVnIFByZXNjcmlwdGlvbnM8
L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y
ZD48a2V5d29yZD5JbmNpZGVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+S25lZSBKb2ludC8qc3VyZ2Vy
eTwva2V5d29yZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs
ZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5PZGRzIFJh
dGlvPC9rZXl3b3JkPjxrZXl3b3JkPlBhaW4gTWVhc3VyZW1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+
UGFpbiwgUG9zdG9wZXJhdGl2ZS9kaWFnbm9zaXMvKmRydWcgdGhlcmFweS9ldGlvbG9neTwva2V5
d29yZD48a2V5d29yZD5QcmV2YWxlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUg
U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+
U21va2luZy9hZHZlcnNlIGVmZmVjdHMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlN0
cmVzcyBEaXNvcmRlcnMsIFBvc3QtVHJhdW1hdGljL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5
d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tl
eXdvcmQ+PGtleXdvcmQ+KlZldGVyYW5zPC9rZXl3b3JkPjxrZXl3b3JkPldhc2hpbmd0b24vZXBp
ZGVtaW9sb2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1
Yi1kYXRlcz48ZGF0ZT5BdWc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI2LTc1
OTggKEVsZWN0cm9uaWMpJiN4RDswMDAzLTI5OTkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24t
bnVtPjI0OTc3NjM2PC9hY2Nlc3Npb24tbnVtPjxsYWJlbD5yMDA5OTg8L2xhYmVsPjx1cmxzPjxy
ZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNDk3
NzYzNjwvdXJsPjwvcmVsYXRlZC11cmxzPjxwZGYtdXJscz48dXJsPmZpbGU6Ly9sb2NhbGhvc3Qv
VXNlcnMvbmFoZWVkaml2cmFqL0Ryb3Bib3gvQXBwcy9QYXBlcnMzL0xpYnJhcnkucGFwZXJzMy9G
aWxlcy81NS81NTM0NUNBQy1CNTkzLTQwRUEtOEFGMC03OThGMDJEMzBFODAucGRmPC91cmw+PC9w
ZGYtdXJscz48L3VybHM+PGN1c3RvbTM+cGFwZXJzMzovL3B1YmxpY2F0aW9uL3V1aWQvODg2RkZF
MTAtQzA4OS00RjVDLUFCRkEtRENGRkE0RUE1NTYyPC9jdXN0b20zPjxlbGVjdHJvbmljLXJlc291
cmNlLW51bT4xMC4xMjEzL0FORS4wMDAwMDAwMDAwMDAwMjkyPC9lbGVjdHJvbmljLXJlc291cmNl
LW51bT48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90
ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb3pldDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA 280 (0%)0 (0%)Continuously filled prescriptions (with no gaps >14 days) in the 12 months after dischargePEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWRsYW5kc215dGg8L0F1dGhvcj48WWVhcj4yMDE4PC9Z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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWRsYW5kc215dGg8L0F1dGhvcj48WWVhcj4yMDE4PC9Z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ADDIN EN.CITE.DATA 2910 (0.01%)<6 (0.0%)Sustained opioid use was defined as a consistently filled prescription beginning within 30 days of hospital discharge and continuing with no more than 30 days elapsing between prescription refills until 6 months post-operatively. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hvZW5mZWxkPC9BdXRob3I+PFllYXI+MjAxNzwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2hvZW5mZWxkPC9BdXRob3I+PFllYXI+MjAxNzwvWWVh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ADDIN EN.CITE.DATA 3093 (0.1%)64 (0.1%)Combination1) 10 or more prescriptions; or 2) >120 days’ supply within the first year of surgery (excluding the first 90 postoperative days) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdW48L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdW48L0F1dGhvcj48WWVhcj4yMDE3PC9ZZWFyPjxSZWNO
dW0+MjE4PC9SZWNOdW0+PERpc3BsYXlUZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+MzEt
MzM8L3N0eWxlPjwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4yMTg8L3JlYy1udW1i
ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ2YXdhZGZhejZ4dHMwa2UwdHIz
eHd0cDh0dmVhczlhNXIwd2QiIHRpbWVzdGFtcD0iMTUyMjUxODQ5NiI+MjE4PC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TdW4sIEUuIEMuPC9hdXRob3I+PGF1dGhvcj5C
YXRlbWFuLCBCLiBULjwvYXV0aG9yPjxhdXRob3I+TWVtdHNvdWRpcywgUy4gRy48L2F1dGhvcj48
YXV0aG9yPk5ldW1hbiwgTS4gRC48L2F1dGhvcj48YXV0aG9yPk1hcmlhbm8sIEUuIFIuPC9hdXRo
b3I+PGF1dGhvcj5CYWtlciwgTC4gQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+
PGF1dGgtYWRkcmVzcz5Gcm9tIHRoZSAqRGVwYXJ0bWVudCBvZiBBbmVzdGhlc2lvbG9neSwgUGVy
aW9wZXJhdGl2ZSBhbmQgUGFpbiBNZWRpY2luZSwgU3RhbmZvcmQgVW5pdmVyc2l0eSBTY2hvb2wg
b2YgTWVkaWNpbmUsIFN0YW5mb3JkIFVuaXZlcnNpdHksIFN0YW5mb3JkLCBDYWxpZm9ybmlhOyBk
YWdnZXJEZXBhcnRtZW50IG9mIEFuZXN0aGVzaWEsIENyaXRpY2FsIENhcmUgYW5kIFBhaW4gTWVk
aWNpbmUsIE1hc3NhY2h1c2V0dHMgR2VuZXJhbCBIb3NwaXRhbCwgQm9zdG9uLCBNYXNzYWNodXNl
dHRzOyBkb3VibGUgZGFnZ2VyRGVwYXJ0bWVudCBvZiBBbmVzdGhlc2lvbG9neSwgSG9zcGl0YWwg
Zm9yIFNwZWNpYWwgU3VyZ2VyeSwgTmV3IFlvcmssIE5ldyBZb3JrOyBzZWN0aW9uIHNpZ25EZXBh
cnRtZW50IG9mIEFuZXN0aGVzaW9sb2d5IGFuZCBDcml0aWNhbCBDYXJlLCBVbml2ZXJzaXR5IG9m
IFBlbm5zeWx2YW5pYSwgU2Nob29sIG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIFBlbm5zeWx2
YW5pYSwgUGhpbGFkZWxwaGlhLCBQZW5uc3lsdmFuaWE7IHx8QW5lc3RoZXNpb2xvZ3kgYW5kIFBl
cmlvcGVyYXRpdmUgQ2FyZSBTZXJ2aWNlLCBWZXRlcmFucyBBZmZhaXJzIFBhbG8gQWx0byBIZWFs
dGggQ2FyZSBTeXN0ZW0sIFBhbG8gQWx0bywgQ2FsaWZvcm5pYTsgcGFyYWdyYXBoIHNpZ25EZXBh
cnRtZW50IG9mIEhlYWx0aCBSZXNlYXJjaCBhbmQgUG9saWN5LCBTdGFuZm9yZCBVbml2ZXJzaXR5
IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQgVW5pdmVyc2l0eSwgU3RhbmZvcmQsIENhbGlm
b3JuaWE7IGFuZCAjTmF0aW9uYWwgQnVyZWF1IG9mIEVjb25vbWljIFJlc2VhcmNoLCBDYW1icmlk
Z2UsIE1hc3NhY2h1c2V0dHMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TGFjayBvZiBB
c3NvY2lhdGlvbiBCZXR3ZWVuIHRoZSBVc2Ugb2YgTmVydmUgQmxvY2thZGUgYW5kIHRoZSBSaXNr
IG9mIFBvc3RvcGVyYXRpdmUgQ2hyb25pYyBPcGlvaWQgVXNlIEFtb25nIFBhdGllbnRzIFVuZGVy
Z29pbmcgVG90YWwgS25lZSBBcnRocm9wbGFzdHk6IEV2aWRlbmNlIEZyb20gdGhlIE1hcmtldHNj
YW4gRGF0YWJhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW5lc3RoIEFuYWxnPC9zZWNvbmRh
cnktdGl0bGU+PHNob3J0LXRpdGxlPkV2aWRlbmNlIEZyb20gdGhlIE1hcmtldHNjYW4gRGF0YWJh
c2U8L3Nob3J0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFuZXN0aCBB
bmFsZzwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjk5OS0xMDA3PC9wYWdlcz48dm9s
dW1lPjEyNTwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTcvMDQvMjI8L2Vk
aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFydGhyb3BsYXN0eSwgUmVwbGFjZW1lbnQsIEtuZWUv
YWR2ZXJzZSBlZmZlY3RzLyp0cmVuZHM8L2tleXdvcmQ+PGtleXdvcmQ+RGF0YWJhc2VzLCBGYWN0
dWFsLyp0cmVuZHM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1
bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2Vk
PC9rZXl3b3JkPjxrZXl3b3JkPk5lcnZlIEJsb2NrLyp0cmVuZHM8L2tleXdvcmQ+PGtleXdvcmQ+
T3Bpb2lkLVJlbGF0ZWQgRGlzb3JkZXJzL2RpYWdub3Npcy9lcGlkZW1pb2xvZ3kvKnByZXZlbnRp
b24gJmFtcDsgY29udHJvbDwva2V5d29yZD48a2V5d29yZD5QYWluLCBQb3N0b3BlcmF0aXZlL2Rp
YWdub3Npcy9lcGlkZW1pb2xvZ3kvKnByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48
a2V5d29yZD5Qb3N0b3BlcmF0aXZlIENvbXBsaWNhdGlvbnMvZGlhZ25vc2lzL2VwaWRlbWlvbG9n
eS9wcmV2ZW50aW9uICZhbXA7IGNvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0b3Jz
PC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+
PGRhdGVzPjx5ZWFyPjIwMTc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48aXNibj4xNTI2LTc1OTggKEVsZWN0cm9uaWMpJiN4RDswMDAzLTI5OTkg
KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI4NDMwNjkyPC9hY2Nlc3Npb24tbnVtPjxs
YWJlbD5yMDA5ODk8L2xhYmVsPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5u
Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yODQzMDY5MjwvdXJsPjwvcmVsYXRlZC11cmxzPjxwZGYt
dXJscz48dXJsPmZpbGU6Ly9sb2NhbGhvc3QvVXNlcnMvbmFoZWVkaml2cmFqL0Ryb3Bib3gvQXBw
cy9QYXBlcnMzL0xpYnJhcnkucGFwZXJzMy9GaWxlcy9BNC9BNDNGQTU5QS0zMTk5LTRBMjAtOUEx
Ri00NDU1OUM2Qjc0NEMucGRmPC91cmw+PC9wZGYtdXJscz48L3VybHM+PGN1c3RvbTM+cGFwZXJz
MzovL3B1YmxpY2F0aW9uL3V1aWQvRURCNDQ3RjYtRkQ5OC00MzUyLThDOEMtRkE4MDA5Qjc0RjAy
PC9jdXN0b20zPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMjEzL0FORS4wMDAwMDAwMDAw
MDAxOTQzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3Vh
Z2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U3VuPC9BdXRob3I+PFllYXI+MjAxNjwv
WWVhcj48UmVjTnVtPjE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ2YXdhZGZhejZ4dHMwa2UwdHIzeHd0
cDh0dmVhczlhNXIwd2QiIHRpbWVzdGFtcD0iMTUwMDEyNTcxNiI+MTwva2V5PjwvZm9yZWlnbi1r
ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp
YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U3VuLCBFLiBDLjwvYXV0aG9yPjxhdXRob3I+RGFybmFs
bCwgQi4gRC48L2F1dGhvcj48YXV0aG9yPkJha2VyLCBMLiBDLjwvYXV0aG9yPjxhdXRob3I+TWFj
a2V5LCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRl
cGFydG1lbnQgb2YgQW5lc3RoZXNpb2xvZ3ksIFBlcmlvcGVyYXRpdmUgYW5kIFBhaW4gTWVkaWNp
bmUsIFN0YW5mb3JkIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBTdGFuZm9yZCwgQ2Fs
aWZvcm5pYS4mI3hEO0RlcGFydG1lbnQgb2YgSGVhbHRoIFJlc2VhcmNoIGFuZCBQb2xpY3ksIFN0
YW5mb3JkIFVuaXZlcnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBTdGFuZm9yZCwgQ2FsaWZvcm5p
YTNOYXRpb25hbCBCdXJlYXUgb2YgRWNvbm9taWMgUmVzZWFyY2gsIENhbWJyaWRnZSwgTWFzc2Fj
aHVzZXR0cy48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbmNpZGVuY2Ugb2YgYW5kIFJp
c2sgRmFjdG9ycyBmb3IgQ2hyb25pYyBPcGlvaWQgVXNlIEFtb25nIE9waW9pZC1OYWl2ZSBQYXRp
ZW50cyBpbiB0aGUgUG9zdG9wZXJhdGl2ZSBQZXJpb2Q8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+
SkFNQSBJbnRlcm4gTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+SkFNQSBJbnRlcm4gTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+
MTI4Ni05MzwvcGFnZXM+PHZvbHVtZT4xNzY8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48a2V5
d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdv
cmQ+PGtleXdvcmQ+QW5hbGdlc2ljcywgT3Bpb2lkL2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2Fn
ZS8qYWR2ZXJzZSBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkFudGlkZXByZXNzaXZlIEFnZW50
cy9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+QmVuem9kaWF6ZXBpbmVzL2FkdmVy
c2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9uL2VwaWRlbWlvbG9neTwva2V5
d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr
ZXl3b3JkPkluY2lkZW5jZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3Jk
Pk9waW9pZC1SZWxhdGVkIERpc29yZGVycy8qZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3Jk
PlBhaW4sIFBvc3RvcGVyYXRpdmUvKnByZXZlbnRpb24gJmFtcDsgY29udHJvbDwva2V5d29yZD48
a2V5d29yZD5SZXRyb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UmlzayBGYWN0
b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlNleCBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0
YW5jZS1SZWxhdGVkIERpc29yZGVycy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U3Vy
Z2ljYWwgUHJvY2VkdXJlcywgT3BlcmF0aXZlL3N0YXRpc3RpY3MgJmFtcDsgbnVtZXJpY2FsIGRh
dGE8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+
PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcCAw
MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjIxNjgtNjExNCAoRWxlY3Ryb25pYykm
I3hEOzIxNjgtNjEwNiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+Mjc0MDA0NTg8L2Fj
Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt
Lm5paC5nb3YvcHVibWVkLzI3NDAwNDU4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj
dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDAxL2phbWFpbnRlcm5tZWQuMjAxNi4zMjk4PC9lbGVj
dHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5PJmFwb3M7
Q29ubmVsbDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT41MDY8L1JlY051bT48cmVj
b3JkPjxyZWMtbnVtYmVyPjUwNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9InZhd2FkZmF6Nnh0czBrZTB0cjN4d3RwOHR2ZWFzOWE1cjB3ZCIgdGltZXN0YW1w
PSIxNTUzODA4MTAwIj41MDY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91
cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y
Pk8mYXBvcztDb25uZWxsLCBDLjwvYXV0aG9yPjxhdXRob3I+QXphZCwgVC4gRC48L2F1dGhvcj48
YXV0aG9yPk1pdHRhbCwgVi48L2F1dGhvcj48YXV0aG9yPlZhaWwsIEQuPC9hdXRob3I+PGF1dGhv
cj5Kb2huc29uLCBFLjwvYXV0aG9yPjxhdXRob3I+RGVzYWksIEEuPC9hdXRob3I+PGF1dGhvcj5T
dW4sIEUuPC9hdXRob3I+PGF1dGhvcj5SYXRsaWZmLCBKLiBLLjwvYXV0aG9yPjxhdXRob3I+VmVl
cmF2YWd1LCBBLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz
Pk8mYXBvcztDb25uZWxsLCBDaGxvZS4gU3RhbmZvcmQgVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVk
aWNpbmUsIFN0YW5mb3JkLCBDYWxpZm9ybmlhLiBBemFkLCBUZWogRGVlcGFrLiBEZXBhcnRtZW50
cyBvZiAyIE5ldXJvc3VyZ2VyeSBhbmQuIE1pdHRhbCwgVmFpc2hhbGkuIFN0YW5mb3JkIFVuaXZl
cnNpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBTdGFuZm9yZCwgQ2FsaWZvcm5pYS4gVmFpbCwgRGFu
aWVsLiBTdGFuZm9yZCBVbml2ZXJzaXR5IFNjaG9vbCBvZiBNZWRpY2luZSwgU3RhbmZvcmQsIENh
bGlmb3JuaWEuIEpvaG5zb24sIEVsaS4gRGVwYXJ0bWVudHMgb2YgMiBOZXVyb3N1cmdlcnkgYW5k
LiBEZXNhaSwgQXRtYW4uIERlcGFydG1lbnRzIG9mIDIgTmV1cm9zdXJnZXJ5IGFuZC4gU3VuLCBF
cmljLiBBbmVzdGhlc2lvbG9neSwgUGVyaW9wZXJhdGl2ZSBhbmQgUGFpbiBNZWRpY2luZS4gUmF0
bGlmZiwgSm9obiBLLiBEZXBhcnRtZW50cyBvZiAyIE5ldXJvc3VyZ2VyeSBhbmQuIFZlZXJhdmFn
dSwgQW5hbmQuIERlcGFydG1lbnRzIG9mIDIgTmV1cm9zdXJnZXJ5IGFuZC48L2F1dGgtYWRkcmVz
cz48dGl0bGVzPjx0aXRsZT5QcmVvcGVyYXRpdmUgZGVwcmVzc2lvbiwgbHVtYmFyIGZ1c2lvbiwg
YW5kIG9waW9pZCB1c2U6IGFuIGFzc2Vzc21lbnQgb2YgcG9zdG9wZXJhdGl2ZSBwcmVzY3JpcHRp
b24sIHF1YWxpdHksIGFuZCBlY29ub21pYyBvdXRjb21lczwvdGl0bGU+PHNlY29uZGFyeS10aXRs
ZT5OZXVyb3N1cmdpY2FsIEZvY3VzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5OZXVyb3N1
cmc8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXVyb3N1cmdp
Y2FsIEZvY3VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+TmV1cm9zdXJnPC9hYmJyLTE+PC9wZXJpb2Rp
Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXVyb3N1cmdpY2FsIEZvY3VzPC9mdWxs
LXRpdGxlPjxhYmJyLTE+TmV1cm9zdXJnPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+
RTU8L3BhZ2VzPjx2b2x1bWU+NDQ8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZGF0ZXM+PHll
YXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh
dGVzPjxhY2Nlc3Npb24tbnVtPjI5MjkwMTM1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVk
LXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NT
Qz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9cHJlbSZhbXA7QU49MjkyOTAx
MzU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5P
dmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5Fbmds
aXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA 31-33509 (0.3%)428 (0.3%)1) ≥10 opioid prescriptions (over ≥90 days); or 2) ≥120 total days’ supply dispensed (within 330 days, excluding the first 30 days) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWViZWw8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYWViZWw8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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 EN.CITE.DATA 34,35286 (0.2%)236 (0.2%)1) Filled prescription within 15 to 90 days after discharge and filled at least one additional opioid prescription between 91 and 180 days after surgery; and, 2) either A) 1150 OMEs total dose OR B) 39 days supplied and 2 filled prescriptions ADDIN EN.CITE <EndNote><Cite><Author>Swenson</Author><Year>2018</Year><RecNum>513</RecNum><DisplayText><style face="superscript">36</style></DisplayText><record><rec-number>513</rec-number><foreign-keys><key app="EN" db-id="vawadfaz6xts0ke0tr3xwtp8tveas9a5r0wd" timestamp="1553808100">513</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Swenson, C. W.</author><author>Seiler, K.</author><author>Kamdar, N.</author><author>Morgan, D.</author></authors></contributors><auth-address>C.W. Swenson, University of Michigan, Ann Arbor, MI, United States</auth-address><titles><title>Prevalence of new persistent opioid use among opioid naive women undergoing hysterectomy</title><secondary-title>American Journal of Obstetrics and Gynecology</secondary-title><tertiary-title>44th Annual Meeting of the Society Of Gynecologic Surgeons, SGS 2018. United States.</tertiary-title></titles><periodical><full-title>American Journal of Obstetrics and Gynecology</full-title></periodical><pages>S885</pages><volume>218</volume><number>2 Supplement 2</number><keywords><keyword>adult,age,anesthesia,anxiety,bivariate analysis,Black person,*cancer surgery,chronic pain,Current Procedural Terminology,depression,diagnosis,disease simulation,education,female,female genital tract cancer,human,*hysterectomy,International Classificatio</keyword></keywords><dates><year>2018</year></dates><pub-location>Netherlands</pub-location><publisher>Mosby Inc.</publisher><isbn>1097-6868</isbn><urls></urls></record></Cite></EndNote>36535 (0.3%)420 (0.3%)Works Cited ADDIN EN.REFLIST 1.Stafford C, Francone T, Roberts PL, Ricciardi R: What factors are associated with increased risk for prolonged postoperative opioid usage after colorectal surgery? Surg Endosc 2018; 0: 0-02.Grace TR, Khanna K, Choo KJ, Croci R, Feeley BT, Ma CB, Zhang AL: The influence of preoperative opioid use on inpatient opioid requirements and discharge prescriptions after primary shoulder arthroplasty. Journal of Shoulder and Elbow Surgery 20183.Hernandez NM, Parry JA, Mabry TM, Taunton MJ: Patients at Risk: Preoperative Opioid Use Affects Opioid Prescribing, Refills, and Outcomes After Total Knee Arthroplasty. Journal of Arthroplasty. 20184.Cancienne JM, Patel KJ, Browne JA, Werner BC: Narcotic Use and Total Knee Arthroplasty. Journal of Arthroplasty 2018; 33: 113-1185.Qureshi R, Werner B, Puvanesarajah V, Horowitz JA, Jain A, Sciubba D, Shen F, Hassanzadeh H: Factors Affecting Long-Term Postoperative Narcotic Use in Discectomy Patients. World Neurosurgery 2018; 31: 316.Ladha KS, Patorno E, Liu J, Bateman BT: Impact of Perioperative Epidural Placement on Postdischarge Opioid Use in Patients Undergoing Abdominal Surgery. Anesthesiology 2016; 124: 396-4037.Holman JE, Stoddard GJ, Higgins TF: Rates of prescription opiate use before and after injury in patients with orthopaedic trauma and the risk factors for prolonged opiate use. Journal of Bone & Joint Surgery - American Volume 2013; 95: 1075-808.Holman JE, Stoddard GJ, Horwitz DS, Higgins TF: The effect of preoperative counseling on duration of postoperative opiate use in orthopaedic trauma surgery: a surgeon-based comparative cohort study. Journal of Orthopaedic Trauma 2014; 28: 502-69.Clarke H, Soneji N, Ko DT, Yun L, Wijeysundera DN: Rates and risk factors for prolonged opioid use after major surgery: population based cohort study. BMJ 2014; 348: g125110.Johnson SP, Chung KC, Zhong L, Shauver MJ, Engelsbe MJ, Brummett C, Waljee JF: Risk of Prolonged Opioid Use Among Opioid-Naive Patients Following Common Hand Surgery Procedures. Journal of Hand Surgery 2016; 41: 947-957.e311.Lee JS, Hu HM, Edelman AL, Brummett CM, Englesbe MJ, Waljee JF, Smerage JB, Griggs JJ, Nathan H, Jeruss JS, Dossett LA: New Persistent Opioid Use Among Patients With Cancer After Curative-Intent Surgery. J Clin Oncol 2017; 35: 4042-404912.Brummett CM, Waljee JF, Goesling J, Moser S, Lin P, Englesbe MJ, Bohnert ASB, Kheterpal S, Nallamothu BK: New Persistent Opioid Use After Minor and Major Surgical Procedures in US Adults. JAMA Surg 2017; 152: e17050413.Lindestrand AG, Christiansen ML, Jantzen C, van der Mark S, Andersen SE: Opioids in hip fracture patients: an analysis of mortality and post hospital opioid use. Injury 2015; 46: 1341-514.Goesling J, Moser SE, Zaidi B, Hassett AL, Hilliard P, Hallstrom B, Clauw DJ, Brummett CM: Trends and predictors of opioid use after total knee and total hip arthroplasty. Pain 2016; 157: 1259-6515.Kim KY, Anoushiravani AA, Chen KK, Roof M, Long WJ, Schwarzkopf R: Preoperative Chronic Opioid Users in Total Knee Arthroplasty-Which Patients Persistently Abuse Opiates Following Surgery? Journal of Arthroplasty 2018; 33: 107-11216.Stark N, Kerr S, Stevens J: Prevalence and predictors of persistent post-surgical opioid use: a prospective observational cohort study. Anaesthesia and intensive care 2017; 45: 70017.Marcusa DP, Mann RA, Cron DC, Fillinger BR, Rzepecki AK, Kozlow JH, Momoh A, Englesbe M, Brummett C, Waljee JF: Prescription Opioid Use among Opioid-Naive Women Undergoing Immediate Breast Reconstruction. Plast Reconstr Surg 2017; 140: 1081-109018.Mueller KG, Memtsoudis SG, Mariano ER, Baker LC, Mackey S, Sun EC: Lack of Association Between the Use of Nerve Blockade and the Risk of Persistent Opioid Use Among Patients Undergoing Shoulder Arthroplasty: Evidence From the Marketscan Database. Anesth Analg 2017; 125: 1014-102019.Pang J, Tringale KR, Tapia VJ, Moss WJ, May ME, Furnish T, Barnachea L, Brumund KT, Sacco AG, Weisman RA, Nguyen QT, Harris JP, Coffey CS, Califano JA, 3rd: Chronic Opioid Use Following Surgery for Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg 2017; 143: 1187-119420.Alam A, Gomes T, Zheng H, Mamdani MM, Juurlink DN, Bell CM: Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med 2012; 172: 425-3021.Pugely AJ, Bedard NA, Kalakoti P, Hendrickson NR, Shillingford JN, Laratta JL, Saifi C, Lehman RA, Riew KD: Opioid use following cervical spine surgery: trends and factors associated with long-term use. Spine Journal 201822.Kulshrestha S, Barrantes F, Samaniego M, Luan FL: Chronic opioid analgesic usage post-kidney transplantation and clinical outcomes. Clin Transplant 2014; 28: 1041-623.Kent ML, Hurley RW, Oderda GM, Gordon DB, Sun E, Mythen M, Miller TE, Shaw AD, Gan TJ, Thacker JKM, McEvoy MD, Group P-W: American Society for Enhanced Recovery and Perioperative Quality Initiative-4 Joint Consensus Statement on Persistent Postoperative Opioid Use: Definition, Incidence, Risk Factors, and Health Care System Initiatives. Anesth Analg 201924.Hansen CA, Inacio MCS, Pratt NL, Roughead EE, Graves SE: Chronic Use of Opioids Before and After Total Knee Arthroplasty: A Retrospective Cohort Study. J Arthroplasty 2017; 32: 811-817 e125.Inacio MC, Hansen C, Pratt NL, Graves SE, Roughead EE: Risk factors for persistent and new chronic opioid use in patients undergoing total hip arthroplasty: a retrospective cohort study. BMJ Open 2016; 6: e01066426.Politzer CS, Kildow BJ, Goltz DE, Green CL, Bolognesi MP, Seyler TM: Trends in Opioid Utilization Before and After Total Knee Arthroplasty. J Arthroplasty 2017: 1-827.Carroll I, Barelka P, Wang CK, Wang BM, Gillespie MJ, McCue R, Younger JW, Trafton J, Humphreys K, Goodman SB, Dirbas F, Whyte RI, Donington JS, Cannon WB, Mackey SC: A pilot cohort study of the determinants of longitudinal opioid use after surgery. Anesth Analg 2012; 115: 694-70228.Rozet I, Nishio I, Robbertze R, Rotter D, Chansky H, Hernandez AV: Prolonged opioid use after knee arthroscopy in military veterans. Anesth Analg 2014; 119: 454-929.Hadlandsmyth K, Vander Weg MW, McCoy KD, Mosher HJ, Vaughan-Sarrazin MS, Lund BC: Risk for Prolonged Opioid Use Following Total Knee Arthroplasty in Veterans. J Arthroplasty 2018; 33: 119-12330.Schoenfeld AJ, Nwosu K, Jiang W, Yau AL, Chaudhary MA, Scully RE, Koehlmoos T, Kang JD, Haider AH: Risk Factors for Prolonged Opioid Use Following Spine Surgery, and the Association with Surgical Intensity, Among Opioid-Naive Patients. J Bone Joint Surg Am 2017; 99: 1247-125231.Sun EC, Bateman BT, Memtsoudis SG, Neuman MD, Mariano ER, Baker LC: Lack of Association Between the Use of Nerve Blockade and the Risk of Postoperative Chronic Opioid Use Among Patients Undergoing Total Knee Arthroplasty: Evidence From the Marketscan Database. Anesth Analg 2017; 125: 999-100732.Sun EC, Darnall BD, Baker LC, Mackey S: Incidence of and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients in the Postoperative Period. JAMA Intern Med 2016; 176: 1286-9333.O'Connell C, Azad TD, Mittal V, Vail D, Johnson E, Desai A, Sun E, Ratliff JK, Veeravagu A: Preoperative depression, lumbar fusion, and opioid use: an assessment of postoperative prescription, quality, and economic outcomes. Neurosurgical Focus 2018; 44: E534.Raebel MA, Newcomer SR, Bayliss EA, Boudreau D, DeBar L, Elliott TE, Ahmed AT, Pawloski PA, Fisher D, Toh S, Donahoo WT: Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf 2014; 23: 1247-5735.Raebel MA, Newcomer SR, Reifler LM, Boudreau D, Elliott TE, DeBar L, Ahmed A, Pawloski PA, Fisher D, Donahoo WT, Bayliss EA: Chronic use of opioid medications before and after bariatric surgery. JAMA 2013; 310: 1369-7636.Swenson CW, Seiler K, Kamdar N, Morgan D: Prevalence of new persistent opioid use among opioid naive women undergoing hysterectomy. American Journal of Obstetrics and Gynecology 2018; 218: S885 ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- andy williams a time for us
- sherwin williams color of the year
- sherwin williams best neutrals 2019
- top sherwin williams neutral colors
- best sherwin williams cream colors
- best sherwin williams warm whites
- sherwin williams popular neutral colors
- sherwin williams paint names list
- top 10 sherwin williams colors
- sherwin williams most popular colors
- sherwin williams white paints
- most popular sherwin williams colors 2019