ANTIBIOTIC SENSITIVITY CHART - Therapeutics Education

ANTIBIOTIC SENSITIVITY CHART

Created by James McCormack, BSc(Pharm), Pharm D and Fawziah Lalji, BSc(Pharm), PharmD, FCSHP

with help from Michael Legal and Tim Lau

Faculty of PharmaceuGcal Sciences, University of BriGsh Columbia, Vancouver, BC

Gram PosiGve Cocci

Gram NegaGve Bacilli

Streptococci

Bacteria

LocaGon

Cephalosporins

Carbapenems

Macrolides

Tetracyclines

Fluoroquinolones

Aminoglycosides/polymyxin

Lincosamides

GlycopepGdes/oxazolidinones

Trimethoprim-Sulfamethoxazole

Chloramphenicol

Metronidazole

Nitrofurantoin/fosfomycin

(JUST BLADDER INFECTIONS)

Rifampin

Fidaxomicin

Streptococci

(pneumoniae/

pyogenes/

viridans)

Enterococci

(Group D strep)

Staph

epidermidis

(coagulase

negaGve)

Brain, oral, respiratory tract,

heart, skin

Intraabdominal,

urinary tract

Skin, prostheGcs

Staph

aureus

Methicillin sensiGve

Community

acquired

Methicillin

resistant

Hospital

acquired

Methicillin

resistant

Non-beta-lactamase producing

Escherichia coli,

Klebsiella pneumoniae,

Haemophilus in?uenzae

Beta-lactamase producing

Escherichia coli,

Klebsiella pneumoniae,

Haemophilus in?uenzae

SPACE

SerraGa marcescens,

Proteus mirabilis,

Acinetobacter sp.,

Citrobacter sp.,

Enterobacter sp.

ESBL

(Extended spectrum betalactamase producing)

Escherichia coli,

Klebsiella pneumoniae

Amoxicillin-clavulanate

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

CefoxiGn/cefotetan

CeZriaxone/cefotaxime

Ce?xime

Ce?pime

Meropenem/imipenem

Ertapenem

Erythromycin

Clarithromycin/azithromycin

Tetracycline/doxycycline

Neisseria meningiGdis

Neisseria gonorrhea

Above the diaphragm

(Peptostreptococcus)

Brain

Pelvic in?ammatory disease/STI

Oral, respiratory tract

Intraabdominal, pelvic

in?ammatory disease

Pencillin G-IV

Ampicillin-IV

Amoxicillin/ampicillin

Cloxacillin

Amoxicillin-clavulanate

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

CefoxiGn/cefotetan

CeZriaxone/cefotaxime

Pseudomonas

aeruginosa

Below the

diaphragm

(Bacteroides sp)

Brain, respiratory tract, intraabdominal, urinary tract

Oral, respiratory tract, heart, skin, bones/joint

Atypicals

Cefazolin/cephalexin

Cefuroxime

CefoxiGn/cefotetan

CeZriaxone/cefotaxime

Ce?xime

CeZazidime

Ce?pime

CeZazidime

Ce?pime

Ertapenem

Clarithromycin/azithromycin JUST H.?u

Tetracycline/doxycycline JUST H.?u

Tetracycline/doxycycline

Tigecycline

Levo?oxacin/moxi?oxacin

Clindamycin

JUST Moxi?oxacin

Clindamycin

Vancomycin/linezolid/ daptomycin

Vancomycin/linezolid/daptomycin

Chloramphenicol

Erythromycin

Clarithromycin/azithromycin

JUST azithromycin

Tetracycline/doxycycline

Tigecycline

Cipro?oxacin

Levo?oxacin/moxi?oxacin

JUST azithromycin

Cipro?oxacin/nor?oxacin BUT JUST bladder infecGons for nor?oxacin

Levo?oxacin/moxi?oxacin

Gentamicin/tobramycin/amikacin/colisGn

Trimethoprim-sulfamethoxazole

Vancomycin oral

Trimethoprim-sulfamethoxazole

Chloramphenicol

Chloramphenicol

Metronidazole

Nitrofurantoin/fosfomycin

JUST E.faecalis

Nitrofurantoin/fosfomycin

Rifampin

Pelvic in?ammatory

disease/STI

Ce?pime

Meropenem/imipenem

Ertapenem

Tigecycline

Clindamycin

Respiratory tract

Chlamydia

trachomaGs

CeZriaxone/cefotaxime

Ce?xime

Meropenem/imipenem

Levo?oxacin/moxi?oxacin

Intraabdominal

Legionella

pneumophilia

Amoxicillin-clavulanate

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

CefoxiGn/cefotetan

Piperacillin-tazobactam

Ce?pime

Meropenem/imipenem

Ertapenem

Erythromycin

Clarithromycin/azithromycin

Tetracycline/doxycycline

Clostridium

di?cile

Mycoplasma

pneumoniae,

Chlamydophilia

spp

Pencillin V/G

Amoxicillin/ampicillin

Amoxicillin-clavulanate

Cloxacillin and clindamycin typically have less than 40% ac6vity for S.epidermidis, thus usage depends on local suscep6bility data

Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium - the an6bio6cs listed work well for E.faecalis, but have limited ac6vity for E.faecium

Cephalosporins have in-vitro ac6vity for SPACE organisms but induce produc6on of beta-lactamases

Tigecycline has no ac6vity for Pseudomonas aeruginosa, but for Acinetobacter it depends on local suscep6bility data; Tigecycline has ac6vity for SPACE organisms, but for Proteus spp it depends on local suscep6bility data

December 2015

Anaerobes

Staphylococci

Pencillin V/G

Amoxicillin/ampicillin

Penicillins

Gram NegaGve Coccobacilli

Nitrofurantoin/fosfomycin

Rifampin

Fidaxomicin

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