ANTIBIOTIC SENSITIVITY CHART - Therapeutics Education
ANTIBIOTIC SENSITIVITY CHART
Created by James McCormack, BSc(Pharm), Pharm D and Fawziah Lalji, BSc(Pharm), PharmD, FCSHP
with help from Michael Legal and Tim Lau
Faculty of PharmaceuGcal Sciences, University of BriGsh Columbia, Vancouver, BC
Gram PosiGve Cocci
Gram NegaGve Bacilli
Streptococci
Bacteria
LocaGon
Cephalosporins
Carbapenems
Macrolides
Tetracyclines
Fluoroquinolones
Aminoglycosides/polymyxin
Lincosamides
GlycopepGdes/oxazolidinones
Trimethoprim-Sulfamethoxazole
Chloramphenicol
Metronidazole
Nitrofurantoin/fosfomycin
(JUST BLADDER INFECTIONS)
Rifampin
Fidaxomicin
Streptococci
(pneumoniae/
pyogenes/
viridans)
Enterococci
(Group D strep)
Staph
epidermidis
(coagulase
negaGve)
Brain, oral, respiratory tract,
heart, skin
Intraabdominal,
urinary tract
Skin, prostheGcs
Staph
aureus
Methicillin sensiGve
Community
acquired
Methicillin
resistant
Hospital
acquired
Methicillin
resistant
Non-beta-lactamase producing
Escherichia coli,
Klebsiella pneumoniae,
Haemophilus in?uenzae
Beta-lactamase producing
Escherichia coli,
Klebsiella pneumoniae,
Haemophilus in?uenzae
SPACE
SerraGa marcescens,
Proteus mirabilis,
Acinetobacter sp.,
Citrobacter sp.,
Enterobacter sp.
ESBL
(Extended spectrum betalactamase producing)
Escherichia coli,
Klebsiella pneumoniae
Amoxicillin-clavulanate
Piperacillin-tazobactam
Cefazolin/cephalexin
Cefuroxime
CefoxiGn/cefotetan
CeZriaxone/cefotaxime
Ce?xime
Ce?pime
Meropenem/imipenem
Ertapenem
Erythromycin
Clarithromycin/azithromycin
Tetracycline/doxycycline
Neisseria meningiGdis
Neisseria gonorrhea
Above the diaphragm
(Peptostreptococcus)
Brain
Pelvic in?ammatory disease/STI
Oral, respiratory tract
Intraabdominal, pelvic
in?ammatory disease
Pencillin G-IV
Ampicillin-IV
Amoxicillin/ampicillin
Cloxacillin
Amoxicillin-clavulanate
Piperacillin-tazobactam
Cefazolin/cephalexin
Cefuroxime
CefoxiGn/cefotetan
CeZriaxone/cefotaxime
Pseudomonas
aeruginosa
Below the
diaphragm
(Bacteroides sp)
Brain, respiratory tract, intraabdominal, urinary tract
Oral, respiratory tract, heart, skin, bones/joint
Atypicals
Cefazolin/cephalexin
Cefuroxime
CefoxiGn/cefotetan
CeZriaxone/cefotaxime
Ce?xime
CeZazidime
Ce?pime
CeZazidime
Ce?pime
Ertapenem
Clarithromycin/azithromycin JUST H.?u
Tetracycline/doxycycline JUST H.?u
Tetracycline/doxycycline
Tigecycline
Levo?oxacin/moxi?oxacin
Clindamycin
JUST Moxi?oxacin
Clindamycin
Vancomycin/linezolid/ daptomycin
Vancomycin/linezolid/daptomycin
Chloramphenicol
Erythromycin
Clarithromycin/azithromycin
JUST azithromycin
Tetracycline/doxycycline
Tigecycline
Cipro?oxacin
Levo?oxacin/moxi?oxacin
JUST azithromycin
Cipro?oxacin/nor?oxacin BUT JUST bladder infecGons for nor?oxacin
Levo?oxacin/moxi?oxacin
Gentamicin/tobramycin/amikacin/colisGn
Trimethoprim-sulfamethoxazole
Vancomycin oral
Trimethoprim-sulfamethoxazole
Chloramphenicol
Chloramphenicol
Metronidazole
Nitrofurantoin/fosfomycin
JUST E.faecalis
Nitrofurantoin/fosfomycin
Rifampin
Pelvic in?ammatory
disease/STI
Ce?pime
Meropenem/imipenem
Ertapenem
Tigecycline
Clindamycin
Respiratory tract
Chlamydia
trachomaGs
CeZriaxone/cefotaxime
Ce?xime
Meropenem/imipenem
Levo?oxacin/moxi?oxacin
Intraabdominal
Legionella
pneumophilia
Amoxicillin-clavulanate
Piperacillin-tazobactam
Cefazolin/cephalexin
Cefuroxime
CefoxiGn/cefotetan
Piperacillin-tazobactam
Ce?pime
Meropenem/imipenem
Ertapenem
Erythromycin
Clarithromycin/azithromycin
Tetracycline/doxycycline
Clostridium
di?cile
Mycoplasma
pneumoniae,
Chlamydophilia
spp
Pencillin V/G
Amoxicillin/ampicillin
Amoxicillin-clavulanate
Cloxacillin and clindamycin typically have less than 40% ac6vity for S.epidermidis, thus usage depends on local suscep6bility data
Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium - the an6bio6cs listed work well for E.faecalis, but have limited ac6vity for E.faecium
Cephalosporins have in-vitro ac6vity for SPACE organisms but induce produc6on of beta-lactamases
Tigecycline has no ac6vity for Pseudomonas aeruginosa, but for Acinetobacter it depends on local suscep6bility data; Tigecycline has ac6vity for SPACE organisms, but for Proteus spp it depends on local suscep6bility data
December 2015
Anaerobes
Staphylococci
Pencillin V/G
Amoxicillin/ampicillin
Penicillins
Gram NegaGve Coccobacilli
Nitrofurantoin/fosfomycin
Rifampin
Fidaxomicin
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