THE BEST ANTIBIOTIC SENSITIVITY CHART EVER (at least the ...

THE "BEST" ANTIBIOTIC SENSITIVITY CHART EVER (at least the best we could make)

Created by James McCormack, BSc(Pharm), PharmD and Fawziah Lalji, BSc(Pharm), PharmD, FCSHP with assistance from Tim Lau

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC

Streptococci

Gram Positive Cocci

Bacteria

Streptococci

(pneumoniae/

pyogenes/

viridans group)

Enterococci

(Group D strep)

Staph

epidermidis

(coagulase

negative)

Location

Brain, oral, respiratory tract,

heart, skin

Intraabdominal,

urinary tract

Skin, prosthetics

Penicillins

Cephalosporins

Carbapenems

Macrolides

Tetracyclines

Fluoroquinolones

Aminoglycosides

Polymyxin

Lincosamides

Glycopeptides/lipoglycopeptides

Oxazolidinones

Trimethoprim-Sulfamethoxazole

Chloramphenicol

Metronidazole

Nitrofurantoin/fosfomycin

(JUST BLADDER INFECTIONS)

Rifampin

Fidaxomicin

Gram Negative Bacilli

Staphylococci

Staph

aureus

(Methicillin sensitive)

Community

acquired

(Methicillin

resistant)

Hospital

acquired

(Methicillin

resistant)

Oral, respiratory tract, heart, skin, bones/joint

Pencillin V/G

Amoxicillin/ampicillin

Amoxicillin-clavulanate

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

Cefoxitin

Ceftriaxone/cefotaxime

Cefixime

Cefipime

Ceftibiprole

Meropenem/imipenem/doripenem

Ertapenem

Erythromycin

Clarithromycin/azithromycin

Tetracycline/doxycycline

Gram Negative Coccobacilli

Pseudomonas aeruginosa

Anaerobes

Neisseria

meningitidis

Neisseria gonorrhea

Above the diaphragm

(Peptostreptococcus)

Brain

Pelvic inflammatory disease/STI

Oral, respiratory tract

Brain, respiratory tract, intraabdominal, urinary tract

Pencillin G-IV

Ampicillin-IV

Amoxicillin/ampicillin

Cloxacillin

Amoxicillin-clavulanate

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

Cefoxitin

Ceftriaxone/cefotaxime

Amoxicillin-clavulanate

Piperacillin-tazobactam

Clostridium

difficile

Intraabdominal, pelvic

Intraabdominal

inflammatory disease

Mycoplasma

pneumoniae,

Chlamydophila

spp

Legionella

pneumophila

Respiratory tract

Chlamydia

trachomatis

Pelvic inflammatory

disease/STI

Amoxicillin-clavulanate

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

Cefoxitin

Ceftriaxone/cefotaxime

Cefixime

Ceftazidime

Ceftolozane-tazobactam

Cefipime

Ceftolozane - tazobactam

Cefipime

Cefipime

Below the diaphragm

(Bacteroides sp)

Atypicals

Pencillin V/G

Amoxicillin/ampicillin

Piperacillin-tazobactam

Cefazolin/cephalexin

Cefuroxime

Cefoxitin

Ceftriaxone/cefotaxime

Cefixime

Ceftazidime

Ceftolozane-tazobactam

Cefipime

Ceftibiprole

Meropenem/imipenem/doripenem

Ertapenem

Erythromycin

Clarithromycin/azithromycin

Tetracycline/doxycycline

Meropenem/imipenem/doripenem

Ertapenem

Meropenem/imipenem/doripenem

Clarithromycin/azithromycin JUST H.flu

Tetracycline/doxycycline JUST H.flu

Clindamycin

Levofloxacin/moxifloxacin

JUST Moxifloxacin

Gentamicin/tobramycin/amikacin

Colistin/polymyxin B

Clindamycin

Clindamycin

Vancomycin/daptomycin

Linezolid/tedizolid

Vancomycin/daptomycin

Linezolid/tedizolid

Trimethoprim-sulfamethoxazole

Chloramphenicol

Erythromycin

Clarithromycin/azithromycin

JUST Azithromycin

Tetracycline/doxycycline

Tigecycline

JUST Ciprofloxacin

Levofloxacin/moxifloxacin

Tetracycline/doxycycline

Tigecycline

Ciprofloxacin/norfloxacin BUT JUST bladder infections for norfloxacin

Levofloxacin/moxifloxacin

Gentamicin/tobramycin/amikacin

Colistin/polymyxin B

Levofloxacin/moxifloxacin

Meropenem/imipenem/doripenem

Ertapenem

JUST Azithromycin

Tigecycline

Vancomycin oral

Trimethoprim-sulfamethoxazole

Chloramphenicol

Chloramphenicol

Metronidazole

Nitrofurantoin/fosfomycin

JUST E.faecalis

Nitrofurantoin/fosfomycin

Rifampin

Cloxacillin and clindamycin typically have less than 40% activity for S.epidermidis, thus usage depends on local susceptibility data

Enterococci has two main species - Enterococcus faecalis and Enterococcus faecium; the antibiotics listed are active against E.faecalis, but have limited activity for E.faecium

Cephalosporins have in-vitro activity for SPACE organisms but induce production of beta-lactamases

Tigecycline has no activity against Pseudomonas aeruginosa, but for Acinetobacter it depends on local susceptibility data; Tigecycline is active against SPACE organisms, but for Proteus spp it depends on local susceptibility data

NOVEMBER 2019

Non-beta-lactamase producing

Escherichia coli,

Klebsiella pneumoniae,

Haemophilus influenzae

SPACE

ESBL

Serratia

Beta-lactamase producing

(Extended spectrum

marcescens,

CRE

Escherichia coli,

beta-lactamase

Proteus mirabilis,

(Carapenem-resistant

Klebsiella pneumoniae,

producing)

Acinetobacter sp.,

Enterobacteriaceae)

Haemophilus influenzae

Escherichia coli,

Citrobacter sp.,

Klebsiella pneumoniae

Enterobacter sp.

Nitrofurantoin/fosfomycin

Rifampin

Fidaxomicin

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